LOCUS       KCXD01000001             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:7163:12109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000001
VERSION     KCXD01000001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:7163:12109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58483.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          123 a          140 c          133 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcca caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000002             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19547:15382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000002
VERSION     KCXD01000002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19547:15382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..471
     V_segment       117..395
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58484.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       404..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..471
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT          104 a          148 c          131 g           90 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccttctggt gcagtctggg gctgaggtga tgcagcccgg ggcctcagtg aaggtctcct
      181 gcaaggtctc cggaaacacc ttcaccgaat tgtccataca ctgggtgcga caggcccctg
      241 gaaaagggct tgagtgggtg ggaagtgttg atcccgcata tggtgaaatg acgttccagg
      301 gcagagtcat catgaccgag gacacgtcta cagacacagc ctacatggag ctgaccagcc
      361 tgacatctga cgacacggcc gtctattact gtgcggttgg ccctagcggc acttggaacc
      421 actggccctt cgatatctgg ggccctggca ccccaatcac catctcctca gcc
//
LOCUS       KCXD01000003             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9199:18875
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000003
VERSION     KCXD01000003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9199:18875"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..491
     V_segment       144..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58485.1"
                     /translation="CTGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          108 a          131 c          153 g          105 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agatggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga atgggtctca gctattaata
      301 ctgatgggga gaacacatac tacgcagact ccgtgaaggg ccgattctcc atctccagag
      361 acaactcaaa gaccacactc tccctgcaaa tgaacagcct gagaccggag gacacggccg
      421 tatattactg tacgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc cacagcc
//
LOCUS       KCXD01000004             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23683:11785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000004
VERSION     KCXD01000004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23683:11785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58486.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       406..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          105 a          149 c          131 g           90 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagccc ggggcctcag tgaaggtctc
      181 ctgcaaggtc tccggaaaca ccttcaccga attgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcccgca tatggtgaaa tgacgttcca
      301 gggcagagtc atcatgaccg aggacacgtc tacagacaca gcctacatgg agctgaccag
      361 cctgacatct gacgacacgg ccgtctatta ctgtgcggtt ggccctagcg gcacttggaa
      421 ccactggccc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01000005             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12310:14253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000005
VERSION     KCXD01000005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12310:14253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..356
     V_segment       8..281
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <275..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58487.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       295..305
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..356
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           77 a           99 c          108 g           74 t
ORIGIN      
        1 acatgggcag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt
       61 ctcctgcagg atttccggat acaccttcac cgaattatcc atacactggg tgcggcaggc
      121 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctgtatggtg aaatgaagtt
      181 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctact tggaactgag
      241 cggcctgact tctgaggaca cggccgtgta ttactgtgcg actggcccta ccggcacctg
      301 gaacgcctgg tacctcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000006             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11373:18211
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000006
VERSION     KCXD01000006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11373:18211"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58488.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       445..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          110 c          155 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcttcgggg ttcatcttca gtagttatgg
      241 catgcactgg gtccgcctgg ctccagggaa ggggctggag tgggtggcag taacatcgtc
      301 tgatgaaagt aagaaattct acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcccag aacatactat atcttcaaat gaacaacctg aaattgaagg acacggccgt
      421 ctactattgt gggagagatg ataatggggt gattattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000007             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:15959:7259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000007
VERSION     KCXD01000007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:15959:7259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58489.1"
                     /translation="CARTGDSGTYYSGEYFDYW"
     D_segment       439..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          120 a          113 c          156 g          123 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcaggagt tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcacttatc tcgtatgatg
      301 gaagtaagaa atattacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ctaagaacat actacatctt caaatgaaca acctgagatt ggaggacacg gccgtgtatt
      421 actgtgcgag aacaggggat agtggtactt attattcggg ggaatacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000008             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9678:16898
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000008
VERSION     KCXD01000008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9678:16898"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..493
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58490.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       430..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          111 a          141 c          146 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgcagtgaa gaggcctggg gcctcagtta
      181 aggtctcctg caaggtttcc ggatactcct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctgtgtat ggtgaagaaa
      301 tacacgcaga gaatttccag gacagagtca ccatgaccga ggacacgtcc acagacacag
      361 cctacatgga gctgagcagc ctgagacgtg aggacacggc cgtgtatttc tgtgcggcgg
      421 gccttggggg gtatttagtt cttactgaat acctcgaatt ctggggccag ggcgccctgg
      481 tcaccgtctc ctccgcc
//
LOCUS       KCXD01000009             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:10715:8551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000009
VERSION     KCXD01000009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:10715:8551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58491.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       439..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..503
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          130 c          150 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcgaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca atacctatgc
      241 tatgcactgg gtccgcctgg ctccagggaa ggggctggag tgggtctcag ctattagtag
      301 tggtggtagc acatactacg tagactccgt gaagggccga ttcaccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagtctgaga gatgaggaca cggcctttta
      421 ttactgtgcg aaaggaggta gcagctcttt ctactggtac ttcgatatcc ggggccctgg
      481 caccccagtc accatctcct cagcc
//
LOCUS       KCXD01000010             421 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17386:17694
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000010
VERSION     KCXD01000010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 421)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 421)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17386:17694"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    35..415
                     /note="immunoglobulin heavy chain variable region"
     V_region        35..415
     V_segment       35..326
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <320..>388
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58492.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       335..357
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       375..415
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        416..>421
                     /gene="IGHG"
BASE COUNT           91 a          109 c          129 g           92 t
ORIGIN      
        1 acatggggtg gcagcagcta caggtgccca gtcccaggtc cacctggtgc agtccggggc
       61 tgaggtgaag aggcctgggg cctcagtgaa gctctcctgc aaggcttctg gatacacctt
      121 cagcatctct gccatcagtt gggtgcgaca ggcccctgga caaggacttg ggtggatggg
      181 agggatcatc cctcttgttg gtatgacaaa ctacgaacag aagttccagg gcagagtcac
      241 gattaccgcg gacacgtcca cgaatacagt cttcatggaa ctgagcagcc tgagatctga
      301 ggacacggcc gtctactatt gtgcgacagg ggtatattac caggatgaat acggttattt
      361 ttatgtcggc ggtgactttg actactgggg ccagggagtc ctggtcaccg tctccccagc
      421 c
//
LOCUS       KCXD01000011             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27958:14250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000011
VERSION     KCXD01000011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27958:14250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..494
     V_segment       116..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58493.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       414..421
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          137 c          150 g          105 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctata gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc agtcccaggt
      121 ccagctggtg cagtccgggg ctgaggtgag gaagcctggg gcctcagtga agctctcctg
      181 caaggcttct ggatacacgt tcagcatcta tgccatcagt tgggtgcgac aggcccctgg
      241 acaagggctt gagtggatgg gagggatcat ccctcttgtt gatgtaacaa actacgcaca
      301 gaagttccag ggcagagtca cgattaccgc ggacacgtcc acaagcacag cctacatgga
      361 gctgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgaggg gagattgtac
      421 tgatactgac tgctcttccg cggggggcgc ctttgatttc tggggccaag gactcagggt
      481 caccgtctct tcagcc
//
LOCUS       KCXD01000012             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14673:9289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000012
VERSION     KCXD01000012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14673:9289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58494.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          132 c          154 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcag
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc aagacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattagta
      301 gtggtggtac cacgtactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctacaaacga acagcctgag agttgaggac ggggccgtgt
      421 attactgtgc gaaaggaggt agcagctctt tctactggta tttcgatatc cggggccctg
      481 gcaccccagt caccatctcc tcagcc
//
LOCUS       KCXD01000013             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:18958:4735
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000013
VERSION     KCXD01000013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:18958:4735"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58495.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       437..444
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          142 c          139 g          102 t
ORIGIN      
        1 atggggagca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggttaagaa gcctggggcc tcagtgaggg
      181 tctcctgcca ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgatcc tgtaaatggt gaaataatac
      301 acgcagacaa cttccagggc agagtcacca tgaccgaaga cacgtctata gacacagcct
      361 acatggaact gagcagcctg agatctgagg atacggccgt atattactgt gcgacccacg
      421 gaggctatag tgacatctgg aactccctgt actacggttt ggattcctgg ggccaagggg
      481 tcttcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000014             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:9616:20716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000014
VERSION     KCXD01000014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:9616:20716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..503
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58496.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       441..455
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          122 c          153 g          119 t
ORIGIN      
        1 acatgggagg agaggagccc agccctggga ttcccaggtg ttttcatttg tgatcagcac
       61 tgaacacaga agactcatca tggagtttgg cctgagctgg gttttccttg ttgctatttt
      121 aaaaggtgtc cagggtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc atcagtaact actggatgta
      241 ctgggttcgc caggcaccag ggaaggggct ggagtggatc tcagccatta atagtgctga
      301 aagtaccaca tactatgcag acgccgtgaa gggcagattc accatctcca gagacaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtaccgggcc tagtggtgtt tactggttcc cttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000015             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23394:6408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000015
VERSION     KCXD01000015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23394:6408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58497.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       443..447
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          139 c          145 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggttttcgg atacaccttc agcgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgaca ctgtctctga cggagtgata
      301 tacgcagaga acttccaggg cagagtcgcc atgaccgagg acacgtctac agacacagcc
      361 tacatggaat tgagcagcct gagatctgag gacacggccg tttattactg tgcgagaggt
      421 ttatcaccag acgtcttcgg tttcctcggg cttggctact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000016             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15065:11719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000016
VERSION     KCXD01000016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15065:11719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58498.1"
                     /translation="CATADSGYPFYYFDFW"
     D_segment       419..426
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          116 a          141 c          128 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggcgca gtctggggct gacgtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aaggacttga gtggatggga ggttttgctc ctatatatgg tgaaataata
      301 cacgcaaagt tccagggcag agtcagtttg accgaggaca cgtccacaga cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtct attattgtgc gacagctgat
      421 agcggttacc cattttacta cttcgatttc tggggccctg gtaccccaat caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000017             366 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20880:2983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000017
VERSION     KCXD01000017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 366)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 366)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20880:2983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..364
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..364
     V_segment       7..277
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>333
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58499.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       292..304
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..364
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        365..>366
                     /gene="IGHG"
BASE COUNT           82 a           90 c          118 g           76 t
ORIGIN      
        1 acatgggggg ctgaggtgaa gaagcctggg gcctcagtaa aggtctcctg ccaggtttcc
       61 ggatacacct tcagtgaaat gtccatgcac tgggtgcgac aggcccctgg aaaagggctt
      121 gagtggatgg gatgtgttgc tcctggaaat ggtgaaataa tacacgcaga gaacttccag
      181 ggcagagtca ccatgaccga ggacacgtct acagacacag cctacatgga gctgagtagc
      241 ctgagatctg aggacacggc cgtgtattac tgtgcgacag ggaggttcgg gagcagcgtc
      301 tggtccagcc tcttctacgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc
      361 tcagcc
//
LOCUS       KCXD01000018             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7394:21395
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000018
VERSION     KCXD01000018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7394:21395"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58500.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       414..423
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          144 c          136 g          101 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc ggtagttact ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gaaatagtgg tagtacctac tatagcccct ccctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccacctc tccctgaagc tgaactctgt
      361 gaccaccgcg gacacggccg tgtatttctg tgcgaacgtc ttaggcccct ggggcagctg
      421 gtcacactac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000019             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10295:3702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000019
VERSION     KCXD01000019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10295:3702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58501.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       423..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          109 a          143 c          143 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctctatatgg tgaaatgatg
      301 ctcgcagaca acttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgac gacacggccg tgtattactg tgcgcgtggg
      421 cctattacaa tttttggcgt acttattacg gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000020             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18965:11220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000020
VERSION     KCXD01000020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18965:11220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58502.1"
                     /translation="CARVVYYDSSYSTSPYNRFDVW"
     D_segment       431..439
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          141 c          142 g          108 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctgggta caccttcagc atctatgcca tcagttgggt gcgacaggcc
      241 cctgggcaag ggcttgagtg gatgggaggg atcatccctc ttgttggtat aacaaattac
      301 gcacagaggt tccagggcag agtcaccatt accgcggaca cgtccacaag cacagcctac
      361 atagacctga gtagcctgag atctgaggac acggccgtgt attactgtgc gagagttgta
      421 tactatgata gtagttattc cacgagtccc tacaaccggt tcgatgtctg gggcccggga
      481 gtcctagtca ccgtctcctc agcc
//
LOCUS       KCXD01000021             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14493:8251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000021
VERSION     KCXD01000021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14493:8251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58503.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       430..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          115 a          142 c          142 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggctggga ggtgttgatc ttgcatatga tgaaataata
      301 cacgcagaga agttccaagg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgct cactgaatac ctcgagttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01000022             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20995:10882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000022
VERSION     KCXD01000022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20995:10882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..330
     V_segment       5..269
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58504.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       270..275
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       285..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           84 a           89 c           92 g           67 t
ORIGIN      
        1 acatggggaa gaagcctggg gcctccgtga aaatctcctg ccaggcttct ggatacacct
       61 taaccgacca ctacctgcac tgggtgcgac aggctcctgg aaaaggactt gagtggatgg
      121 gaggtgttca tcctgaatat gggaaagtag actacacaca gaagttccaa gacagagtca
      181 ccatcaccgc ggacatgtcg acagagacag tctacatgga gctgagcagc ctgagatctg
      241 aggacacggc cacttattac tgtgtgacag tgggtcccta ccattacttt gactactggg
      301 gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000023             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:25451:4376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000023
VERSION     KCXD01000023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:25451:4376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..471
     V_segment       111..407
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58505.1"
                     /translation="CARDRLGGGWFDYW"
     D_segment       418..429
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           96 a          134 c          140 g          103 t
ORIGIN      
        1 acatggggga tgggaaatgt tctctgagag tcatggacct cctgtgcaag aacatgaagc
       61 acctgtggtt cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc
      121 tacaggagtc gggcccagga gtggtgaagc cttcggagac cctgtccctc acctgcgctg
      181 tctctggtgg ctccatcagc gatagttaca ggtggagctg gatccgtcag cccccaggga
      241 aggaactgga gtggataggg tacatctatg gtggtaatac gggcaccaac tacaacccct
      301 ccctcaaaag tcgagtcacc atttcaaaag acacgtccac gaaccagttc tccttgaaac
      361 tgagctctgt gaccgccgcg gacacggccg tgtattcctg tgcgagagat cggcttggcg
      421 gtggctggtt tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000024             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20258:9821
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000024
VERSION     KCXD01000024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20258:9821"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58506.1"
                     /translation="CTKGRSGGVWPNSFDYW"
     D_segment       423..432
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          133 c          141 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagttg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga tttatccatg cactgggtgc gacaggcccc
      241 aggaaaaggg cttgagtgga tgggaagtgt tgatcctgta tatggtgaaa taattgtcgc
      301 agacaatttc caggacagag tcaccatgac cgaggacacg tctaccgaca cagcctacat
      361 ggagctgagc agcctggaat ctgacgacac ggccatgtat tactgtacga aagggaggag
      421 tggtggtgtc tggccgaact cctttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000025             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14975:3950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000025
VERSION     KCXD01000025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14975:3950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58507.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       443..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          121 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 ttgatgaaac taaggaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgtgagagat tcttacggcc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000026             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15707:19037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000026
VERSION     KCXD01000026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15707:19037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..512
     V_segment       142..435
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58508.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       458..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>516
                     /gene="IGHG"
BASE COUNT          104 a          131 c          160 g          121 t
ORIGIN      
        1 acatgggggc agctctgaga caggagcctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttgg tgattatggc
      241 atgcactggg tccgccaggc tccgggaaag ggactggagt gggtctcatc cattaggaac
      301 actggtaaaa tcgtatacta cgctgactcc gtgaagggcc gattcaccat ttccagagac
      361 aacgccaaga actcgctgtc tctgcgaatg agcagcctga gagccgagga cacggccgtg
      421 tactactgta ctagaattgg cgtcggatct ctggcaacgg ctggtgacta ctttgaccac
      481 tggggccagg gagtcctggt caccgtctcc tccgcc
//
LOCUS       KCXD01000027             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16003:15333
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000027
VERSION     KCXD01000027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16003:15333"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58509.1"
                     /translation="CARAGFSGSESFYGLDIW"
     D_segment       406..415
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           91 a          139 c          135 g          110 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agctcctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agtctttggg gaccctgtcc ctcacctgcg atgtctctgg
      181 tggctccatc agcagtaact actggagctg gatccgccag gcccccggga agggactgga
      241 atggattgga cgtttctctg gtagtggtgg aaacaccgac tacaacccct ccctcacctc
      301 tcgagtcacc ttttcaacag acacgtccaa gaaccagttt tccctgaggc tgaaatctgt
      361 gaccgccgcg gacacggccg tctatttctg tgcgagagcc ggatttagcg gcagcgaaag
      421 tttctacggt ttggatattt ggggccaagg ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01000028             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22785:2855
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000028
VERSION     KCXD01000028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22785:2855"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58510.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       433..439
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          119 a          141 c          141 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaaat gaagaagcct ggggcctcag ttagggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt cgatcctgca caaggtgaaa taatacacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagccttcat
      361 ggaattgagc agcctgacat ctgaggacac ggccgtgtat ttctgtgcga aaggggggtt
      421 cggaaccagc gtctggtcca atctcttcta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000029             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24001:17954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000029
VERSION     KCXD01000029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24001:17954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58511.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       430..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          123 c          157 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agcactggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaggtggt ggagtctggg ggcggcttgg caaagcctgg
      181 gggatccctg agactctcct gtgcagcctc tggattcacc ttcagtacct atgctatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcagccatta gtgttggtgg
      301 tagtacatac tacgcagact ccgtgagggg ccgattcacc atctccagag acaactcaga
      361 gaacacgctc tccctacaaa tgaacagcct gagagctgag gacacggccg tgtattactg
      421 tgcgaaaggg gatacagcta cagtttatta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000030             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8830:9758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000030
VERSION     KCXD01000030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8830:9758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..498
     V_segment       126..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58512.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       447..453
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          143 c          141 g          104 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagttggtg cagtccgggg ctgaggtgat gaagcctggg gcctcagtga
      181 agctctcctg caaggcttct ggatacaccc tcagtatctc tgccatcagt tgggtacgac
      241 aggcccctgg acaagggctt gagtggatgg gagagatctt ccctcttgtt ggtatgacaa
      301 aatacgcaca gaacttccag ggcagagtca cgattaccgc ggacacgtcc acaagtacag
      361 cctacatgga gctgagcggc ctgagatctg aggacacggc cgtatattac tgtgcgaaaa
      421 ggggtggcca cggtaccacc accacgttgt acttctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000031             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:4931:12638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000031
VERSION     KCXD01000031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:4931:12638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58513.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       433..437
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          121 c          141 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgctgcta ttttaagagg
      121 tgtccagtgt gaggtccacc tggtggaatc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt tcctttggca tgcactgggt
      241 ccgccaggca ccggggaagg ggctggagtg ggtggcagtt ttatcgtctg atggaactaa
      301 caaatactac gcagactctt tgaaagaccg attcaccata tccagagaca actccaagaa
      361 catactatat cttcaactga acaacctgaa attggaggac acggccgtgt attactgtgc
      421 gagagatgtg tatggctcgg ggcttgacta ctggggccag ggagtcctgc tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000032             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17914:11893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000032
VERSION     KCXD01000032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17914:11893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    77..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        77..457
     V_segment       77..368
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <362..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58514.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       377..399
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>463
                     /gene="IGHG"
BASE COUNT           98 a          122 c          139 g          104 t
ORIGIN      
        1 acatgggcag ctcatcacca tggacttgac ctggaggctc ctctttgtgg tggcagcagc
       61 tacaggtgcc cagtcccagg tccacctggt gcagtccggg gctgaggtga agaagcctgg
      121 ggcctcagtg aagctctcct gcaagacttc tggatacacc ttcagcatct ctgccatcag
      181 ttgggtgcga caggcccctg gacaagggct tgggtggatg ggagggatca tccctcttgt
      241 tggtgtgaca aactacgaac agaagttcca gggcagagtc acgattaccg cggacacgtc
      301 cacgaataca gtcttcatgg aactgagcag cctgagatct gaggacacgg ccgtctacta
      361 ttgtgcgaca ggggtatatt accaggatga atacggttat ttttatgtcg gcggtgactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01000033             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11819:14874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000033
VERSION     KCXD01000033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11819:14874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58515.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cggcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatgaaag taagaaatac tacggagact ctgtgaaggg ccgattcagc atctccagag
      361 acaattcgaa gaacatacta tatcttcaaa tgaacaccct gaaattggag gacacggccg
      421 tgtattactg tgcgacagat gcgtttggta gcgggattga ccactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000034             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10902:14070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000034
VERSION     KCXD01000034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10902:14070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58516.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       417..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          120 a          141 c          130 g           97 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtaaagga gcctggggcc tcagtaaagg
      181 tctcctgcaa ggtttccgga ttcaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagttgag cagcctaaga tctgaggaca cggccctgta ttactgtgca gtcggctata
      421 gcggcagatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01000035             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20171:18300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000035
VERSION     KCXD01000035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20171:18300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58517.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          121 c          154 g          126 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtactagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000036             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16914:14531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000036
VERSION     KCXD01000036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16914:14531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58518.1"
                     /translation="CAGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          107 a          126 c          154 g          110 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aaatggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gctcttaatt
      301 atgatgggga tagtacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgcacagcct gagagaagat gacacggccg
      421 tttatttctg tgcgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000037             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10780:19349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000037
VERSION     KCXD01000037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10780:19349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58519.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          118 a          142 c          144 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctgcag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000038             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5584:17405
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000038
VERSION     KCXD01000038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5584:17405"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58520.1"
                     /translation="CASSGIEVVAYSIDYC"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          133 c          135 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagg tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tgtggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000039             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16615:8603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000039
VERSION     KCXD01000039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16615:8603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58521.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       436..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          118 c          149 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggagcctt ggttcgccct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagtttt gtcgtctgat
      301 ggaggttaca aataccacgc agactctaag aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tcctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga gaggagaata cagtaactct attgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000040             423 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:11031:7423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000040
VERSION     KCXD01000040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 423)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 423)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:11031:7423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    43..417
                     /note="immunoglobulin heavy chain variable region"
     V_region        43..417
     V_segment       43..350
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <343..>390
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58522.1"
                     /translation="CVSADSGYPPYFFDIW"
     D_segment       357..366
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       378..417
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        418..>423
                     /gene="IGHG"
BASE COUNT           69 a          123 c          128 g          103 t
ORIGIN      
        1 acatggggac tgtgggtctc tctgttcaca ggggtcctgt cccagctgca cctgcaggag
       61 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      121 ggctctatca gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggag
      181 tggattgggt gtatctttgg tggtggtatc tttggtggtg gaagtaacac cttctacagc
      241 ccttccctca agagtcgagt caccctgtca gtggacgcgt ccaagaccca gctctccctg
      301 aagctgacgt ctgtgaccgc cgcggacacg gccgtgtatt tctgtgtgag cgctgatagt
      361 ggttatcctc cctacttctt tgacatctgg ggccagggag tcctggtcac cgtctcccca
      421 gcc
//
LOCUS       KCXD01000041             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22044:18084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000041
VERSION     KCXD01000041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22044:18084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58523.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       436..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..500
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          129 c          149 g          117 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcgaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcaata cctatgctat
      241 gcactgggtc cgcctggctc cagggaaggg gctggagtgg gtctcagcta ttagtagtgg
      301 tggtagcaca tactacgtag actccgtgaa gggccgattc accatctcca gagacaactc
      361 aaagaacacg ctctccctgc aaatgaacag tctgagagat gaggacacgg ccttttatta
      421 ctgtgcgaaa ggaggtagca gctctttcta ctggtacttc gatatccggg gccctggcac
      481 cccagtcacc atctcctcag cc
//
LOCUS       KCXD01000042             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17315:10543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000042
VERSION     KCXD01000042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17315:10543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58524.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       423..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          119 a          145 c          132 g           96 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg attcaccttc accgatttat ccatacactg gatacgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggaat tgagcagcct gaaatctgac gacacggccg tatattactg tgcgagtggc
      421 cctagcggca cctggatcga ctggtccttc gatgtctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01000043             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23100:14804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000043
VERSION     KCXD01000043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23100:14804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58525.1"
                     /translation="CARWEAASFDYW"
     D_segment       403..407
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           84 a          131 c          136 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccgtcagc ggtggttatg gctggagctg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtatctatg gtcatagtgg tagcacccgc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacactgccg tgtatttctg tgcgagatgg gaagctgcct cttttgacta
      421 ctggggtcag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000044             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:10646:13597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000044
VERSION     KCXD01000044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:10646:13597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..508
     V_segment       136..429
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58526.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       446..459
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          107 a          122 c          154 g          127 t
ORIGIN      
        1 acatggggct gagacaggag tcttagccct ggattccaag aacttccact ttgggatcag
       61 ctctgaacac agaggaccat ggagttgggg ctgagctggg ttttccttgt tgctatttta
      121 aaaggtgtcc agtgtgaggt ggagctggtg gagtctgggg gaggcttggt ccagcctggg
      181 gggtccctga gactctcctg tgtagcctct ggattcacct ttggtgatta tggcatgcac
      241 tgggtccgcc aggctccggg aaagggactg gagtgggtct catccattag aaacactggt
      301 aaaatcgtat actacgctga ctccgtgaag ggccgattca tcatctccag agacaacgcc
      361 aagaattcgc tgtctctgca aatgaacagc ctgagagtcg aggactcggc cgtctattac
      421 tgtactagaa ttggcgtcgg atctctagca ccggctggtg aatactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000045             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8469:8272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000045
VERSION     KCXD01000045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8469:8272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58527.1"
                     /translation="CATSPSGSWLFWYFDFW"
     D_segment       422..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          143 c          138 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag atttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaagg ttccagggca gagtcacctt gaccgaagac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcagc tggctatttt ggtacttcga tttctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000046             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18088:4857
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000046
VERSION     KCXD01000046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18088:4857"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..501
     V_segment       135..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58528.1"
                     /translation="CTRGIDNYHFSNTDFDFW"
     D_segment       436..443
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          117 c          141 g          131 t
ORIGIN      
        1 acatgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag atcaggactg
       61 aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt gctatattaa
      121 aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta caacctgggg
      181 cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat gacatgcact
      241 gggttcgcca ggctccaggg aagggtctgg agtgggtttc cggtattaac attggcggtg
      301 acacatacta cccagactct gtgaagggtc gattcactat ctccagagac aacgccaaga
      361 actccttgta tcttctaatg aacagcctga gagttgagga cactgctgtg tatttttgta
      421 caagggggat agataactac cactttagta atacggactt tgacttctgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000047             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24665:15700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000047
VERSION     KCXD01000047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24665:15700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58529.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       404..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           83 a          139 c          139 g          103 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctggc cctcacctgc gctgtctctg
      181 gtggctccat cagtggttac tggtggggct ggatccgcca gtccccaggg agggggctgg
      241 aatggattgg atttttcggt ggtagtggtg ggaacaccta ctacaagtcc tccctccaga
      301 gtcgagtcac catttcagcc gacccgtcca agaaccagtt ctccctgata ctgacctctg
      361 tgaccgccgc ggacacggcc ctctattact gtgcgcgggg gaatatagca gcgactggca
      421 ttgactactg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000048             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23658:20134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000048
VERSION     KCXD01000048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23658:20134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..333
     V_segment       8..258
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <253..>303
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58530.1"
                     /translation="CARSPSGSWLYWYFDFW"
     D_segment       268..279
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..333
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
BASE COUNT           77 a           94 c           88 g           74 t
ORIGIN      
        1 acatgggctg gggcctcagt gaaggtctcc tgcaaagttt ccggatacac cttcaccgaa
       61 ttttccatgc actggctacg acaggcccct ggaaaagggc ttgagtggat gggaggtgtt
      121 gatcctgctt ttggtgaaat gatacacgca gagaaattcc agaacagagt caccctgacc
      181 gaggacacct ctacagacac agcctacatg gagctgacta gcctgagatc tgaggactcg
      241 gccgtgtatt actgtgcgcg ctcacccagc ggcagctggc tatactggta cttcgatttc
      301 tggggccctg gcaccccaat caccatctcc tca
//
LOCUS       KCXD01000049             307 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:23409:12247
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000049
VERSION     KCXD01000049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 307)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:23409:12247"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..305
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..305
     V_segment       8..244
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <236..>274
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58531.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       245..250
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       260..305
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        306..>307
                     /gene="IGHG"
BASE COUNT           75 a           83 c           82 g           67 t
ORIGIN      
        1 acatgggatc tcctgccagg cttccggata caccttaacc gaccactacc tacactgggt
       61 gcgacaggct cctggaaaag gacttgagtg gatgggaggt attcttcctg agtatggtaa
      121 agttgactac acacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga
      181 gacagtctac atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt
      241 gacagtgggt ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc
      301 ctcagcc
//
LOCUS       KCXD01000050             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22628:23575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000050
VERSION     KCXD01000050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22628:23575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..428
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58532.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       442..446
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          103 a          126 c          152 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggaatctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcatc cggattcacc ttcagtgacc actgcatgca
      241 ctgggtccgc caggcttcag ggaaggggct ggggtgggtc tcaggtatta cttatactgg
      301 tgttaccact tgggacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc acatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgtgaca ggaaggcgac acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000051             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14664:19212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000051
VERSION     KCXD01000051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14664:19212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58533.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       409..415
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          113 a          133 c          131 g          106 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacttggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagt tggcgcagtc tggggctgac gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgtaagg tttccggata caccttcacc gaattatccc tgcactgggt gcgacagggc
      241 cctggaaaag gacttgagtg gatgggaggt tttgctccta tatatggtga attaatccat
      301 gaaaggttcc agggaagagt cagtttgacc gaggacacgt ctacagacac agcctatatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtgtatt attgtgcggc agctgacagt
      421 ggttacccat tttactactt cgatatttgg ggccctggca ccccaatcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000052             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14171:4708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000052
VERSION     KCXD01000052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14171:4708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58534.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       428..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          115 a          141 c          141 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggctgggagg tgttgatctt gcatatgatg aaataataca
      301 cgcagagaag ttccaaggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctga gatctgagga cacggccgtg tattactgtg cggcgggcct
      421 tgggggatat ttactgctca ctgaatacct cgagttctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01000053             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:8899:6692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000053
VERSION     KCXD01000053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:8899:6692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58535.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       428..435
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          105 a          139 c          146 g          101 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgatgtgaa gaagcctggg gcctcagtga
      181 agctctcctg caaggcttct ggattcgcct tcagaatgta tgccctcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagggatcgt ccctcttgtt ggaacaacaa
      301 actccgcaca gaagttccag ggcagagtca cgattaccgc ggacacgtcc acaagcacag
      361 tctacatgga gttgagcagc ctgagatctg aggacacggc catgtattac tgtgcgagag
      421 gcctgggtag cagcgcccac tttggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01000054             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:10441:11520
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000054
VERSION     KCXD01000054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:10441:11520"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58536.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          141 c          136 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccaggaaa ggggctggag
      241 tggattgggt ttttcggtgg ttatggtggg agcacctact acaacccctc cctccagagt
      301 cgagtcacca tttcagccga cacgtccaaa caccagttct ccctgatact gacctctgtg
      361 accgccgcgg acacggccct ctactattgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000055             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21298:3393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000055
VERSION     KCXD01000055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21298:3393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58537.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          120 c          145 g          116 t
ORIGIN      
        1 acatggtgtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgccatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca tcttcagtac ctatgccatg
      241 cactgggtcc gccaggctcc agggaagggg ctggaatggg tggcagttat ttcgcatgat
      301 gaaactaaga gatactacac agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tacaatatct tcacatgaac aacctgaaat tggaggacac ggccatatac
      421 tactgtgcgg cctcctactt ggggtacgga tttgagtact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000056             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:9879:19904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000056
VERSION     KCXD01000056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:9879:19904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58538.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       453..467
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          115 a          126 c          148 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgacta
      241 tgccctgagc tgggtccgcc aggcttctgg gaaaggactg gagtggattg gctatattag
      301 aagccaatat aacaatttcg cgacagaata cgccccgtcg gtgaaaggca gattcaccat
      361 ctccagagat gattcaaaga acacgctatt tctgcaaatg agtaacctga gaaccgagga
      421 cacggccgtg tattactgca ccacccattt tggtggtaat tattacttgg actactttgt
      481 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000057             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23776:16880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000057
VERSION     KCXD01000057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23776:16880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58539.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          102 a          123 c          162 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtcggggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 tcatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaata
      301 gtggtgggga tgatacatac tatgcagact ccgtgaaggg ccgattcacc ttgtccagag
      361 agaacgccaa gaacacactg tatcttcaca tggtcagcct gagaggtgag gacacggctg
      421 tctattactg tgcgagagac cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000058             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21792:2469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000058
VERSION     KCXD01000058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21792:2469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58540.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       438..458
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          107 c          157 g          126 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagatgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt gacagttata tcgtatgatg
      301 gaagtacgaa gtactatgta gactctgtga aggaccgatt caccatctcc agagacaatt
      361 cgaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgtgag agtagactgt agtggtggtg tctgctactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcgtca gcc
//
LOCUS       KCXD01000059             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11095:17552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000059
VERSION     KCXD01000059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11095:17552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58541.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          102 a          123 c          159 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttat gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcggctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta gcagtggtgg
      301 ggatgacaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaccaca ctgtatcttc aaatggacag cctgacagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcgtt gtcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000060             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10415:12067
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000060
VERSION     KCXD01000060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10415:12067"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58542.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       438..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          110 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt aacggcatgc
      241 actgggtccg ccaggttcca gggaaggggc tggagtgggt ggcagtgaca tcgtttgatg
      301 aaagtacgaa atactacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agactcttat ggaagtggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000061             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21089:7845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000061
VERSION     KCXD01000061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21089:7845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58543.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       440..444
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          121 c          146 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gctgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttcc tttggcatgc
      241 actgggtccg ccaggcaccg gggaaggggc tggagtgggt ggcagtttta tcgtctgatg
      301 gaactaacaa atactacgca gactctttga aagaccgatt caccatatcc agagacaact
      361 ccaagaacat actatatctt caactgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtgtat ggctcggggc ttgactactg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000062             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12769:2723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000062
VERSION     KCXD01000062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12769:2723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58544.1"
                     /translation="CARVRGWYLGYFDYW"
     D_segment       401..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           95 a          141 c          129 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctccatca acaataacta ctggacctgg atccgccagc ccccaggaaa gggactggag
      241 tggattggac gtatcgctgg cactggtggg aacaccgact acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtgc gcggctggta cttaggctac
      421 tttgactatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000063             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21854:3321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000063
VERSION     KCXD01000063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21854:3321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58545.1"
                     /translation="CARVGENTGGAEDFDFW"
     D_segment       445..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          115 a          114 c          156 g          127 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 gtattttaag aggtgtccag tgtgagttac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagtctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtca cttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccga gaacatgcta tttcttcaaa tgaacaacct gaaattggac gacacggccg
      421 tgtatttctg tgcgagagtt ggagagaata ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000064             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:16917:10953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000064
VERSION     KCXD01000064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:16917:10953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58546.1"
                     /translation="CARERCSASSCAGFLDSW"
     D_segment       432..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>495
                     /gene="IGHG"
BASE COUNT          112 a          141 c          142 g          100 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggaaca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa
      181 gtttcctgca aggcttctgg attcactctc gacaactatg gcatcaactg ggtgcgccag
      241 gcccctggac aggggcttga gtggatggga gtgatcatcc cccttattgg aataacaaac
      301 tacgcagaga acgtccaggg cagagtcgcg atttccgcgg acacgtccat aaatatagcc
      361 tacatggagg tgcgcagcct gagatctgag gacacggcca tctattactg tgcgcgagaa
      421 cgttgttccg ctagcagttg cgccggattc ctcgactcct ggggccaggg agccctggtc
      481 accgtctcct tagcc
//
LOCUS       KCXD01000065             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21318:6891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000065
VERSION     KCXD01000065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21318:6891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58547.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       454..461
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          122 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacctact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgacg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatat ttcgacttct ggggccaggg
      481 cgcactggtc actgtctcct cagcc
//
LOCUS       KCXD01000066             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17647:5431
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000066
VERSION     KCXD01000066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17647:5431"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58548.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       447..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag actccaggga aggggctgga gtgggtggca gttaaatcat
      301 ttgatggaac taagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggaa gacacggccg
      421 tttattactg tgtgagggat gcctacggga gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000067             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:12232:12366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000067
VERSION     KCXD01000067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:12232:12366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58549.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          122 c          157 g          128 t
ORIGIN      
        1 acatggggag ctctgagaca ggagtcttag gcctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtggagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgtagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagaaacac
      301 tggtaaaatc gtatactacg ctgactccgt gaagggccga ttcatcatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gtcgaggact cggccgtcta
      421 ttactgtact agaattggcg tcggatctct agcaccggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000068             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23914:6262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000068
VERSION     KCXD01000068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23914:6262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..282
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..282
     V_segment       9..212
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <204..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58550.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       218..227
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..282
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        283..>284
                     /gene="IGHG"
BASE COUNT           66 a           71 c           85 g           62 t
ORIGIN      
        1 acatggggag ttacgaaatg agttgggtcc gccaggctcc gggaaagggg ctggagtggg
       61 tctcatatat ttgtcacact ggtgaaacca tataccacgc tgactccgtg aagggccgat
      121 tcaccatctc cagagacaac gccaagaatt cgctgtctct gcaaatgagc agcctgagag
      181 ccgaggacac ggccgtgtat tactgtacta ggaaccggaa tactgtaatg attgggtggt
      241 tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000069             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8179:10695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000069
VERSION     KCXD01000069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8179:10695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58551.1"
                     /translation="CARTDCTGGVCYFDYW"
     D_segment       451..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          112 a          115 c          157 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatggactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctatgaagga ccgattcacc ctctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tctattactg tgcgagaacg gattgtactg gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000070             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:5810:11966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000070
VERSION     KCXD01000070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:5810:11966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58552.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          123 c          147 g          107 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagtgtcac cgaattatcg cttcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aagaaattca
      301 cggagaggag ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagttg agcaacctga gatctgagga cacggccgtg tattattgtg cgagtgggtt
      421 tagtatctgg ttattttatg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000071             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13850:15529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000071
VERSION     KCXD01000071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13850:15529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58553.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       443..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          111 a          117 c          159 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg cccagtgtga ggtacgactg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tccggattca ccttctgtac ctttggcatg
      241 cactgggtcc gccaggctcc agggaaggga ctggagtggg tggcactgat atcatatgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccctctc cagagacaat
      361 tccgagaaca tcctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttttgtgcga gagttggaga gggtactggt ggtgcggagg actttgactt ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000072             279 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23473:14013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000072
VERSION     KCXD01000072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 279)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 279)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23473:14013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..277
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..277
     V_segment       8..216
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <208..>246
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58554.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       227..231
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       235..277
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        278..>279
                     /gene="IGHG"
BASE COUNT           60 a           81 c           77 g           61 t
ORIGIN      
        1 acatggggca gtggtttcta ctggacctgg atccgccaac ccccagggaa ggggctggag
       61 tggattgggt gtatcggtgg taatagtggg accacctact acaacccctc cctcaagagt
      121 cgagccgcca tttcaaaaga cacgtccaac aatcaattct ccctgaggtt gagttctctg
      181 accgccgcgg acacggccgt gtattactgt gcgagagatg aagacccctc catttttgac
      241 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000073             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:16155:11259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000073
VERSION     KCXD01000073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:16155:11259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    58..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        58..436
     V_segment       58..349
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <343..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58555.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       372..378
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       387..436
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           98 a          115 c          135 g           90 t
ORIGIN      
        1 acatggggga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
       61 gtccaactgg tgcagtctgg ggctgaaatg aagaagcctg gggcctcagt tagggtctcc
      121 tgcaaggttt ccggaaacac cttcaccgaa ttatccatgc actgggtgcg acaggcccct
      181 ggaaaagggc ttgagtggat gggatgtgtc gatcctgcac aaggtgaaat aatacacgca
      241 gagaaattcc agggcagagt caccatgacc gaggacacgt ccacagacac agccttcatg
      301 gagttgagca gcctgagatc tgaggacacg gccgtgtatt tctgtgcgaa aggggggttc
      361 ggaaccagcg tctggtccaa cctcttctac ggcttggatt cttggggcca aggggtcgtc
      421 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000074             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12760:8655
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000074
VERSION     KCXD01000074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12760:8655"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58556.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          122 c          153 g          126 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctatat
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcggggcc tggagtggat ctcagctatt gatagtgctg
      301 ttactagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000075             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20890:3604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000075
VERSION     KCXD01000075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20890:3604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58557.1"
                     /translation="CTRIWCPRDLTSGCNWFDVW"
     D_segment       457..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          106 a          130 c          156 g          125 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggagcacct cgtggagtct gggggaggcc tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagg ctctggattc atctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaagggg actggaatgg gtctcgtcca ttagtaacac
      301 tggtaaaact atatactaca ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgcccagaac tcggtgtctc tgcagatgaa cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaatttggt gtccccgcga tttaaccagc ggctgtaatt ggttcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000076             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8586:15398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000076
VERSION     KCXD01000076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8586:15398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58558.1"
                     /translation="CATSPSDSWLFWYFDFW"
     D_segment       427..433
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          143 c          137 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag atttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaagg ttccagggca gagtcacctt gaccgaagac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcgacagc tggctatttt ggtacttcga tttctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000077             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18645:11801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000077
VERSION     KCXD01000077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18645:11801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58559.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          121 a          143 c          142 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctgggg cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 acacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 cttcatggaa ttgagcagcc tgacatctga ggacacggcc gtgtatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaatct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01000078             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17122:12342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000078
VERSION     KCXD01000078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17122:12342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    150..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        150..507
     V_segment       150..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58560.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       451..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          115 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgagaaac agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta gatattcaaa tgagcaacct gaaattggag gacacggccg
      421 tctattactg tgcgagaatg gattgcactg gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000079             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18720:15012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000079
VERSION     KCXD01000079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18720:15012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58561.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       412..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          113 a          134 c          133 g          106 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacttg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggcgca gtctggggct gacgtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccttc accgaattat ccctgcactg ggtgcgacag
      241 ggccctggaa aaggacttga gtggatggga ggttttgctc ctatatatgg tgaattaatc
      301 catgaaaggt tccagggaag agtcagtttg accgaggaca cgtctacaga cacagcctat
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc ggcagctgac
      421 agtggttacc cattttacta cttcgatatt tggggccctg gcaccccaat caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000080             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12361:15776
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000080
VERSION     KCXD01000080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12361:15776"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58562.1"
                     /translation="CANALTGGLDYW"
     D_segment       436..444
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          103 a          125 c          157 g          106 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg tactggatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctatt actagtggtg
      301 gggatagcac gtactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaaaaacac gctctccctg caaatgaaca gccttagagc ggaggacacg gccgtgtatt
      421 actgtgccaa cgcattaact ggggggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01000081             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12044:17096
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000081
VERSION     KCXD01000081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12044:17096"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58563.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          137 c          127 g          108 t
ORIGIN      
        1 acatggggaa agctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccag atgggtcctg tcccaggtgc agctacagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc ggcaatagct actggaactg gatccgccag cccccaggga agggtctgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000082             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15871:12877
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000082
VERSION     KCXD01000082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15871:12877"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58564.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       422..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          143 c          132 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggcccag ctggtgcagt ctggggcgga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acatcttcac cgaattatcg ttccactggg tgcgccaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatttggtg aaatgataca
      301 cacagagaaa ttccagggca gaatcaccat gaccgaggac acgtccacag acacagccta
      361 catggaacta agcagcctga gatctgagga cacggccgtg tatttctgtg cgatatcatc
      421 cagcggcagc tggctattct ggtatttcga catctggggc cctggcactc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000083             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8321:4672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000083
VERSION     KCXD01000083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8321:4672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..332
     V_segment       8..257
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58565.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       271..277
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..332
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           85 a           88 c           91 g           70 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caacgtttcc ggatacatct taaccgaatt
       61 atccatacac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaagtgttga
      121 tcctcaatat ggtgaaatga tagacgcaga gaaattccag ggcagagtca ccatgaccga
      181 ggacacgtct acagacacag cctacatgga gctgagcagt ctgagatctg aggacacggc
      241 cgtgtattac tgtgcgacat catccagcgg cacctggcta tactggtact tcgatatctg
      301 gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01000084             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21738:13925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000084
VERSION     KCXD01000084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21738:13925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58566.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          139 c          127 g          107 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcgg ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcac cagtagctac tggaactgga tccgccagcc ccccgggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agtactgtga
      361 ccgccgcgga caccgccgtg tattactgtg tgagatatga ggatgaatcc attaactacc
      421 actttgactt ctggggccag ggagtcctag tcaccgtctc ctcagcc
//
LOCUS       KCXD01000085             351 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6062:11661
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000085
VERSION     KCXD01000085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 351)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 351)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6062:11661"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..349
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..349
     V_segment       7..279
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>318
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58567.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       289..295
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       305..349
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        350..>351
                     /gene="IGHG"
BASE COUNT           75 a           91 c          109 g           76 t
ORIGIN      
        1 acatgggggg gcggcttggc aaagccgggg gggtccctga gactctcctg cgcagtctct
       61 ggattcagtt tcagtcacta cttcatgagc tgggtccgcc aggctccagg gaagggactg
      121 gagtggatct cagggattaa cagtggtgga gataccacac actatgcaga ctccgtgaag
      181 ggcagattca ccatgtccag agagaacgcc aagaacacac tgtcccttca aatggacggc
      241 ctgagagctg aagactcggc tgtctattat tgtgcgagag atcgacgtgt acagtcgtta
      301 tcctggttcg atgtctgggg cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000086             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23060:3247
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000086
VERSION     KCXD01000086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23060:3247"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..413
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58568.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       425..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          140 c          139 g          102 t
ORIGIN      
        1 catggggact caacaactgc atccaacctc aagagaagcc cctgagagca cagtttctca
       61 ccatggactt gacctggaag atcctcctct tggtgacagc agccacaggt gcccactccc
      121 aggtgcaact ggtgcagtct gggggtgaga ttaagcagcc tggggcctca gtgaagctct
      181 cctgtcaggc ttctggatat tccctcactc actacttcat gcactgggtg agacaggccc
      241 ctggacaggg ccttgagtgg ataggactga tcacccctca caatgatcat aaagtctacg
      301 cacagaactt ccagggcaga gtcaccataa ctacggacac gtccacgagc acagtgtcca
      361 tggagctgag cagcctgaga tccgaagaca cagccgtata ctactgtgcg agaggggggg
      421 acatagaata ttgtactggt agtggttgtg gggagcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000087             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15255:4654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000087
VERSION     KCXD01000087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15255:4654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..492
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58569.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       434..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>499
                     /gene="IGHG"
BASE COUNT          111 a          134 c          149 g          105 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtggagtc cggggctgag gtgaagaagc ctggggcctc agcgaagctc
      181 tcctgcaagg ccgctggata cattttcagt acctctgcca tcagttggct gcgacaggcc
      241 cctggacaag ggcttgagtg gatggggggg atcatgcctc ttgttggtag aacaaactac
      301 gcacagaggt tccagggcag agtcacgatt accgcggaca cgtccacaag gacagccaac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc gagcggtggt
      421 ttccaggatg agaacggtta ctattttcca gactattttg acttttgggg ccagggagtc
      481 ctggtcaccg tcctcagcc
//
LOCUS       KCXD01000088             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17165:9794
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000088
VERSION     KCXD01000088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17165:9794"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58570.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcatca
      481 tctcctcagc c
//
LOCUS       KCXD01000089             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9552:3220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000089
VERSION     KCXD01000089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9552:3220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58571.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       421..436
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          102 a          143 c          129 g          106 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gttcttcatt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcgcc ctcctcctgg ctgttctcca aggagtctgt
      121 gccgaggtga aactggtgca gtctggggca gaggtgagaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accaccaact ggatcagttg ggtgcgccag
      241 acgcccggaa aaggcctgga atggatgggg accatctatc ctgctgattc tgaggccaaa
      301 tacaacccgt ccttccaagg ccacgtcact atctcagccg acaagtccat cagtaccacc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtatttctg tgcgaaaacc
      421 tactatagtg gtagtttgga aatctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000090             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22229:10426
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000090
VERSION     KCXD01000090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22229:10426"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..485
     V_segment       116..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58572.1"
                     /translation="CASAAGGTTGVGGSLDVW"
     D_segment       418..426
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..485
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          104 a          138 c          149 g           96 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc agtcccaggt
      121 ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga aactctcctg
      181 ccagacctct ggatacagct tcagcatcta tgccatcagt tgggtgcgac aggcccctgg
      241 acaaggactt gagtggatgg gagggatcgt ccctcttgtt cctaaaatag actacgcaca
      301 gaagttccag ggcagagtca cgattaccgc ggacacgtcc acaagtacag ctttcatgga
      361 actgagcggc ctcaaatctg acgacacggc cgtatattac tgtgcgagcg cggcgggtgg
      421 aacaacgggg gtgggcggct cactggatgt ctggggccgg ggagttctgg tcgccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000091             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24859:8470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000091
VERSION     KCXD01000091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24859:8470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58573.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       441..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          120 c          158 g          120 t
ORIGIN      
        1 acatggggtc tgagagagga gccttagccc tggatttcaa ggcacttcca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggagg cttggtccag
      181 cctggagggt ctctgagact ctcctgtgta gcctctggat tcagcttcag aagttacgaa
      241 atgagttggg tccgccaggc tccgggaaag gggctggagt gggtctcata tattagtcac
      301 actggtgaaa ccatatacca cgctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga attcgctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtg
      421 tattactgta ctaggaaccg gaatactgta atgattgggt ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000092             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16155:16506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000092
VERSION     KCXD01000092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16155:16506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58574.1"
                     /translation="CAREGISASGVDYW"
     D_segment       398..404
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           82 a          136 c          144 g           99 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtacaa cttcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc cccagggaag gggctggagt
      241 ggattgggtt tttcggtggt cgcaatggga acacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaccagac acgtccaaag accagttctc cctgaggctg aggtctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagggaggg gatatcagcg tcgggggtcg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000093             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13409:12004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000093
VERSION     KCXD01000093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13409:12004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58575.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       412..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          105 a          149 c          133 g           94 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcccgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cccgcatatg gtgaaatgac
      301 attccagggc agagtcttca tgaccgagga cacgtctaca gacacagcct acatggagct
      361 gaccagcctg acatctgacg acgcggccgt ctattactgt gcggttggcc ctagcggcac
      421 ttggaaccac tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01000094             318 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2263:16997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000094
VERSION     KCXD01000094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 318)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 318)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2263:16997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..316
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..316
     V_segment       5..255
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <247..>285
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58576.1"
                     /translation="CVRDSSGSGFDYW"
     D_segment       262..267
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..316
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        317..>318
                     /gene="IGHG"
BASE COUNT           80 a           76 c           85 g           77 t
ORIGIN      
        1 acatgggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tacttctggc
       61 atacactggg tccgcctggc tccagggaag gggctggagt gggtggcagt tatatcgtac
      121 gatgaaaata agaaatacta tacagactct gtgaaggacc gattcaccat ctccagagac
      181 aattccaaaa acatggtata tcttcacatg aacaacctga aattggagga cacggccgtg
      241 tattactgtg tgagagattc aagcggttcg ggatttgact attggggcca gggagtcctg
      301 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000095             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23721:19049
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000095
VERSION     KCXD01000095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23721:19049"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58577.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       406..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           92 a          134 c          137 g          113 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccttcagaga ccctgtccct cacctgcgct gtctctggag
      181 gctctctcag cggtggttat gactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg ctatatctat ggtggtagtg ggagcaccac ctacaacccg tccctcagga
      301 atcgagtcac catttcaaaa gacacgtcca agaaccagtt gtccctgagg ctgatctctg
      361 tgaccgccgc ggacacggcc gtatattatt gtgcgagaca gtgctgttac tatgatgact
      421 ttttagacta ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000096             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:28855:17218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000096
VERSION     KCXD01000096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:28855:17218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..471
     V_segment       108..400
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58578.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       413..421
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           97 a          131 c          141 g          104 t
ORIGIN      
        1 acatgggggg gaaatgttct ctgagagtca cggacatcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag ctgcagctgc
      121 aggagtcggg cccaggactg gtgaagcctc cggagaccct gtccctcacc tgcgctgtct
      181 ctggtgggtc tatcagaagt agttactgca gctggatccg ccagacccca gggaagggac
      241 tggagtggat tgggtatatc tatgggagtg atagtagtac caactacaac ccctccctca
      301 agagtcgagt caccctgtca gtagacacgt ccaagaacca gtgctccctg aagttgagcg
      361 ctgtgaccgc cgcggacacg gccgtgtatt attgtgcgag ttcgggtata gaagtggttg
      421 cctacagcat tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000097             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15226:22212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000097
VERSION     KCXD01000097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15226:22212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58579.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          151 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcgccctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttttg tcgtctgatg
      301 gaggttacaa ataccacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000098             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18461:7568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000098
VERSION     KCXD01000098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18461:7568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..485
     V_segment       125..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58580.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          114 a          135 c          133 g          105 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggactt ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggcgc agtctggggc tgacgtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacacctt caccgaatta tccctgcact gggtgcgaca
      241 gggccctgga aaaggacttg agtggatggg aggttttgct cctatatatg gtgaattaat
      301 ccatgaaagg ttccagggaa gagtcagttt gaccgaggac acgtccacag acacagccta
      361 tatggagctg agcagcctga gatctgagga cacggccgtg tattattgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000099             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9630:13146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000099
VERSION     KCXD01000099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9630:13146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..340
     V_segment       8..278
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58581.1"
                     /translation="CATADYGNSLDYW"
     D_segment       284..295
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..340
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>343
                     /gene="IGHG"
BASE COUNT           81 a           86 c           96 g           80 t
ORIGIN      
        1 acatgggggg ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtactt ttggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggagtgggtg gcagttatat cgtctgatgg aagtatgaaa tactacgcag actctatgaa
      181 ggaccgattc accatctcca gagacaattc caagaacata ctatatcttc aaatgaagaa
      241 cctgaaattg gaggacactg ccgtctatta ttgtgcgaca gccgactacg gtaacagcct
      301 tgactactgg ggccagggag tcctggtcac cgtctcctca acc
//
LOCUS       KCXD01000100             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17602:7758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000100
VERSION     KCXD01000100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17602:7758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58582.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          110 c          149 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtacaattag tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagagcat gctctatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 attgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000101             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5571:12175
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000101
VERSION     KCXD01000101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5571:12175"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58583.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          125 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 cattaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgacag
      301 tggtggacat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000102             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24332:14496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000102
VERSION     KCXD01000102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24332:14496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..446
     V_segment       92..385
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58584.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       396..405
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT          102 a          104 c          134 g          108 t
ORIGIN      
        1 acatgggatc agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt
       61 ccttgttgct attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctggaggagg
      121 cttggttcgg cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag
      181 taattttggc atccactggg tccgccaggc tccagggaag ggcctggagt gggtggcagt
      241 tacatcgtct gatgaaagta agaaatacta tgcagactct gtgaaggacc gattcaccat
      301 ctccagagac aattccatga acatggtata tcttcaaatg aacaacctga agttggagga
      361 cacggccgtc tattactgtg cgagagacgc atatggcagc ggctgtgact actggggcca
      421 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000103             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9544:8093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000103
VERSION     KCXD01000103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9544:8093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58585.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       416..425
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          137 c          143 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggagg tgttgatcct ctatatggtg aaaaaagaca
      301 cgcagagaag ttccagggca gagtctccat gaccgaggac acgtctacaa acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tactattgtg cgagaggata
      421 ttgtagcggt agtcactgct cgtccggatt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000104             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13119:24238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000104
VERSION     KCXD01000104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13119:24238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..438
     V_segment       84..363
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58586.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       374..386
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..438
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           96 a          123 c          134 g           87 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaggtct ttctggtgca gtctggggct gaggtgaagc
      121 agcctggggc ctcagtgaag gtctcctgca aggtttccgg atacaccctc accgaagtgt
      181 ccactcactg ggtgcgacag gcccccggaa aagggcttga gtgggtggga agtgttgatc
      241 ctgcatatgg tgaaatgaag ttccagggca gagtcaccat gaccgaggac acgtccacag
      301 acacagccta catggaattg agcagcctaa gatctgagga cacggccgtg tattactgtg
      361 cgattggacc taccggcagg tggaacggct ggtccttcga tatctggggc cctggcaccc
      421 caatcaccat ctcctcagcc
//
LOCUS       KCXD01000105             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5429:19251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000105
VERSION     KCXD01000105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5429:19251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..322
     V_segment       10..261
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <253..>291
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58587.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       270..281
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..322
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>324
                     /gene="IGHG"
BASE COUNT           76 a           78 c           96 g           74 t
ORIGIN      
        1 acatgggcgg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat
       61 tatggcatgc actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttatg
      121 tcgtctgatg gaactaagac attctacgca gactctgtga aggtccgatt caccatctcc
      181 agagacaatt ccaagaacat gctatatctt caaatgaaca gcctgaaatc ggaggacacg
      241 gccgtgtatt actgtgggag agatgataat ggggtgatta tcgactactg gggccaggga
      301 gtcctggtca ccgtcgcctc agcc
//
LOCUS       KCXD01000106             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:23698:15786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000106
VERSION     KCXD01000106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:23698:15786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58588.1"
                     /translation="CARRRYSGYTYGGANFDYW"
     D_segment       399..413
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          139 c          143 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgacgc cttcggagac cctgtccctc acctgcactg tctctggtgg
      181 ctccatcagc ggttactact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggggt atcggtggtg gtagtgggac caccgactac aacccctccc tcaaaagtcg
      301 aatcaccatt tcaagagaca cgtccaagaa ccagttctcc ctgaagctga tctctgtgac
      361 cgccgcggac acggccgtgt ttttctgtgc gagaaggaga tacagcgggt acacctacgg
      421 aggggcgaac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000107             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16312:5673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000107
VERSION     KCXD01000107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16312:5673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..521
     V_segment       152..443
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58589.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       448..462
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT           96 a          161 c          143 g          123 t
ORIGIN      
        1 acatgggggg tctccctcac cacccagctg gggatctcag tgcttcattt tctgtccttc
       61 atttctcagt gcttcatttc tgtcctccac cacgatgggg tcaactgcca tcctcgccct
      121 cctcctggct gttctccaag gagtctgtgc cgaggtgcag ctggtgcagt ctggagcaga
      181 ggtgaagagg cccggggaat ctctgaggat ctcctgtcag acttctggat acagttttgc
      241 caactactgg atcgcctggg tgcgccagat gcccgggaaa ggcctggagt ggatggggat
      301 catctatcct ggtgattctg acaccaagta cggcccgtcc ttcgaaggcc aggtcaccat
      361 ctcagccgac aagtccacca gcaccgccta cctgcagtgg agcagcctga aggcctcgga
      421 caccgccacg tattactgtg cgagactctg gggtgattat tacgcactcc agtactactt
      481 cgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000108             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:4440:7756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000108
VERSION     KCXD01000108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:4440:7756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58590.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       434..440
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          112 c          159 g          124 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgctgctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtggc tttggcatac
      241 actgggtccg ccaggctcct gggaaggggc tggagtgggt gtcacttata tcgtatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccttgtcc agagacaatt
      361 ccaagaacat ggtatatctt cacatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag agttagtggg catacagagg ggacagttga aaactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000109             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24229:17870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000109
VERSION     KCXD01000109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24229:17870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..438
     V_segment       84..376
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58591.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       377..383
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT          101 a           98 c          132 g          109 t
ORIGIN      
        1 acatgggaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
       61 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      121 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagctatg
      181 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      241 ctgatgaaga taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      301 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      361 tgtattactg tgcgagggat gataatgggg tgcttatcga cttctggggc cagggagtcc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000110             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20212:7133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000110
VERSION     KCXD01000110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20212:7133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58592.1"
                     /translation="CVSNLRGNTYTYWRSFDFW"
     D_segment       453..460
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          111 a          130 c          156 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gtccagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcatacatt agtattggtg
      301 gtagtaatag aaactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 cagagaaaac gctctccctg caaatgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgtgtc gaacctacgt ggaaacacct acacttactg gcggtccttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000111             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:12683:7978
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000111
VERSION     KCXD01000111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:12683:7978"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58593.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          121 c          157 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtctgg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tggtgggact accacaaatt atgcagactc cgtgaggggc agcttcacca tctccagaga
      361 gaacgccaag aacagactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat cattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000112             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18255:20647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000112
VERSION     KCXD01000112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18255:20647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58594.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          137 c          130 g          109 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagagcatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggccctg tcccaggtgc ttctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcaatagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaaccccg ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000113             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4619:8889
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000113
VERSION     KCXD01000113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4619:8889"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58595.1"
                     /translation="CARDVRGTGFDFW"
     J_segment       275..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           79 a           77 c           90 g           73 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
       61 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      121 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      181 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccat
      241 atattactgt gcgagagatg tcaggggcac ggggtttgac ttctggggcc agggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000114             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17422:15463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000114
VERSION     KCXD01000114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17422:15463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58596.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       437..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..501
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          139 c          147 g          113 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 ccactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttcttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcgaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcaac acctatgcta
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagct attagtactg
      301 ctggtagcac atactacgca gactccgtga agggccgctt caccgtctcc agagacaact
      361 caaagaacac gctctccctc caagtgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgcgaa aggaggtagc agctctttct actggtactt cgatatccgg ggccctggca
      481 ctccagtcac catctcctca gcc
//
LOCUS       KCXD01000115             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13908:16722
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000115
VERSION     KCXD01000115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13908:16722"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..343
     V_segment       9..267
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <259..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58597.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       281..296
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..343
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           76 a           90 c          103 g           76 t
ORIGIN      
        1 acatggggga ggcctggggc ctcagtgaag gtctcctgca aggtttccgg agacaccttc
       61 accgaattat ccgtgcactg ggtgcgacag gcccctggaa aagggcttga gtgggtggga
      121 ggtgttcatc ctctatatgg taaaataaca cacgcagaga acttccagga cagagtcatc
      181 atgaccgagg acacgtcgac agacacagcc tacatggagc tgagcagcct gacatctgag
      241 gacacggccg tctattactg tgcgagagga ttttgtcatg gtacttattg ctcctcgggt
      301 cttgtctcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000116             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4967:7419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000116
VERSION     KCXD01000116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4967:7419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58598.1"
                     /translation="CARGMDNHHYSNTDFDYW"
     D_segment       451..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          117 c          150 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga atctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtagctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtatca ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 atgccaagaa gtccttgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtgc aagggggatg gataaccacc actatagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000117             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6192:7015
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000117
VERSION     KCXD01000117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6192:7015"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..284
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <276..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58599.1"
                     /translation="CTRGSYSGSYYFNRFDVW"
     D_segment       290..309
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       311..360
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           73 a          104 c          103 g           82 t
ORIGIN      
        1 acatgggggg cccaggactg gtgaagcctt cggagaccct gtccctcaca tgcgctgtct
       61 ctggtggctc tatcagcagt agtacctggt ggaactggat ccgccagccc ccagggaaag
      121 gcctggagtg gattgggtat ataagtggtg atagtggtag cacctactac aacccctccc
      181 tcaagagtcg aatcaccatt tcaacagaca cgtccacgag ccagttctcc ctgaggctga
      241 gctctgtgac cgccgcggac acggccgtgt attactgtac gagaggttcc tatagtggta
      301 gttattactt caaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01000118             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20489:5746
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000118
VERSION     KCXD01000118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20489:5746"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58600.1"
                     /translation="CVRGMDNYHYINTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          121 c          146 g          126 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gtcttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctacgacatg
      241 cactgggtcc gccaggctcc agggaagggt ctggagtggg tttcaggtat taacattggc
      301 gatgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagagctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccactac attaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000119             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22266:14819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000119
VERSION     KCXD01000119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22266:14819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..481
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58601.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       405..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           96 a          138 c          133 g          116 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gttgcacgag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 gtctccatca acattaacta ctggagctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttatctatgg tggtgatggc tacaccacct ccaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gaagtctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatc cgcgttacga ggatgatcac
      421 ggttactatt ctgtggaaat tgactactgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000120             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6531:13557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000120
VERSION     KCXD01000120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6531:13557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58602.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          117 c          148 g          120 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgtggtgca gctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaacctttgg
      241 catgcattgg gtccgccagg ctccagggaa gggactggag tgggtggcag ttatatcgtc
      301 tgatggaggt tacaaatact acgcagactc taagaaggac cgattcacca tctccagaga
      361 caattccaag aacatcctat atcttcaact gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgagagggg aatacagtaa ctctattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000121             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11294:11134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000121
VERSION     KCXD01000121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11294:11134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58603.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       413..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          146 c          136 g           89 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccctca ccgaagtgtc cactcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtccacaga cacagcctac atggaactga
      361 gcagcctaag atctgaggac acggccgtgt attactgtgc gattggccct accggcaggt
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000122             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24045:6317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000122
VERSION     KCXD01000122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24045:6317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58604.1"
                     /translation="CVRDVYGSGLDYW"
     D_segment       438..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          117 c          148 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgc tgctatttta
      121 agaggtgtcc agtgtgaggt ccacctggtg gaatctggag gaggcttggt tcagccgggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtacctt tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtctgatgga
      301 agtaagaaat actacgcaga ctctttgaaa gaccgattca ccatatccag agacaactcc
      361 aagaacatag tatatcttca actgaacagc ctgaaattgg aggacacggc cgtgtattac
      421 tgtgtgagag atgtgtatgg ctcggggctt gactactggg gccagggagt cctgctcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01000123             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15554:16239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000123
VERSION     KCXD01000123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15554:16239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58605.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          113 c          153 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgcttt ttcttcaaat ggacaacctg aaattggagg acacggccgt
      421 ctattattgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000124             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15078:22407
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000124
VERSION     KCXD01000124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15078:22407"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..456
     V_segment       78..371
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58606.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       380..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           91 a          131 c          127 g          109 t
ORIGIN      
        1 acatggggct gtgcaagaac atgaagcacc tgtggttctt ccttctcctg gtggcagctc
       61 ccagatgggt cctgtcccag gtgcagttgc acgagtcggg cccaggactg gtgaagcctt
      121 cggagaccct gtccctcacc tgcggtgtct ctggtgtctc catcaacatt aactactgga
      181 gctggatccg ccagtcccca gggaaggggc tggagtggat tgggtttatc tatggtggtg
      241 atggctacac cacctccaat ccctccctca agagtcgagt caccatttca acagacacgt
      301 ccaagaacca gttttccctg aagctgaagt ctgtgaccgc cgcggacacc gccgtgtatt
      361 actgtgcgag atatccgcgt tacgaggatg atcacggtta ctattctgtg gaaattgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000125             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12908:22069
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000125
VERSION     KCXD01000125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12908:22069"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58607.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       426..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          142 c          135 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggccca gctggtgcag tctggggcgg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacatcttca ccgaattatc gttccactgg gtgcgccagg
      241 cccctggaaa agggcttgag tgggtgggaa gtggtgatcc tgcatatggt gaaatgatac
      301 acacagagaa attccagggc agaatcacca tgaccgagga cacgtccaca gacacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtatttctgt gcgatatcat
      421 ccagtggcag ctggctattc tggtatttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000126             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9174:18905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000126
VERSION     KCXD01000126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9174:18905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..509
     V_segment       134..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58608.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       429..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..509
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          105 a          125 c          157 g          124 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tctgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcagcttt ggcgatcatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagta atactggtaa
      301 agccgtacac tacgctgact ccgtgaaggg ccgattcacc atctccagag acaacgccaa
      361 gaactcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg tatattactg
      421 ttgtagcgat tactatagtg gtagttatta ctattggggc tacggcttgg attcctgggg
      481 ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01000127             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15165:6402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000127
VERSION     KCXD01000127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15165:6402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58609.1"
                     /translation="CTRIGFGSLAVAGHYFDFW"
     D_segment       455..464
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          103 a          127 c          156 g          128 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcacct ggtggagtct gggggagact tggtccagcc
      181 tggggggtcc ctgagactct cctgtgtagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttgataggac
      301 ggctaaaacc gtctactacg ctgactccgt gaggggccga ttcaccattt ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttattgtact agaattggct ttggatctct agcagtggct ggtcactact ttgacttctg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000128             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19266:15159
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000128
VERSION     KCXD01000128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19266:15159"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..475
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58610.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       416..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>481
                     /gene="IGHG"
BASE COUNT           85 a          144 c          139 g          113 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaac aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agtaccaact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtgt atctttggtg gtggtatctt tggtggtgga agtaacacct actacagccc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagacccagc tctccctgaa
      361 gttgacgtct gtgaccgccg cggacacggc cgtatatttc tgtgcgagcg ctgacagtgg
      421 ttatcctccc tacttctttg acatctgggg ccagggagtc ctggtcaccg tctccccagc
      481 c
//
LOCUS       KCXD01000129             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18461:14650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000129
VERSION     KCXD01000129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18461:14650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58611.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          123 c          160 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatattac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa tacgctctcc ctgcaaatga acagcctgag agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01000130             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11309:20703
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000130
VERSION     KCXD01000130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11309:20703"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58612.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          120 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag
      361 acaactccaa gaacatagta tatcttcaac tgaacagcct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01000131             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11521:6560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000131
VERSION     KCXD01000131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11521:6560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..429
     V_segment       63..355
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58613.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       368..376
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       386..429
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           93 a           97 c          141 g          100 t
ORIGIN      
        1 acatggggga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcggccact
       61 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      121 tctcctgcaa ggtttccgga tacagtgtca ccgaattatc gcttcactgg gtgcgacagg
      181 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgtaaaaggt gaagaaattc
      241 acggagagga gttccaggac agagtcacca tgaccgagga cccgtctaca gacacagcct
      301 acatggagtt gagcaacctg agatctgagg acacggccgt gtattattgt gcgagtgggt
      361 ttagtatctg gttattttat gacgttttgg attcctgggg ccaaggggtc gtcgtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01000132             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7263:8400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000132
VERSION     KCXD01000132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7263:8400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58614.1"
                     /translation="CVRDSSGSGFDFW"
     D_segment       438..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          111 c          148 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcattact tctggcatac
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtaaatctt cacatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agattcaagc ggttcgggat ttgacttttg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000133             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16280:6964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000133
VERSION     KCXD01000133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16280:6964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..486
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58615.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       416..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>490
                     /gene="IGHG"
BASE COUNT          118 a          142 c          132 g           98 t
ORIGIN      
        1 acagggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gctacagctt cgccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggttttgct agtatatatg gtcaaataat
      301 acatacagag agattccagg gcagagtcac catgacagcg gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgacatctga ggacacggcc gtgtattact gtgcggcagc
      421 tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctccgcc
//
LOCUS       KCXD01000134             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9355:9003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000134
VERSION     KCXD01000134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9355:9003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..482
     V_segment       122..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58616.1"
                     /translation="CATADSGYPFYYFDFW"
     D_segment       417..424
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          116 a          140 c          127 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggcgcagt ctggggctga cgtgaagaag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa ggacttgagt ggatgggagg ttttgctcct atatatggtg aaataataca
      301 cgcaaagttc cagggcagag tcagtttgac cgaggacacg tccacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtctat tattgtgcga cagctgatag
      421 cggttaccca ttttactact tcgatttctg gggccctggt accccaatca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000135             413 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:2102:10326
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000135
VERSION     KCXD01000135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 413)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 413)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:2102:10326"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    45..411
                     /note="immunoglobulin heavy chain variable region"
     V_region        45..411
     V_segment       45..335
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <327..>380
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58617.1"
                     /translation="CARGVDNHHYSDTEFDLW"
     D_segment       357..363
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       377..411
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        412..>413
                     /gene="IGHG"
BASE COUNT           93 a           98 c          120 g          102 t
ORIGIN      
        1 acatgggggt tttccttgtt gctatattaa aaggtgtcca gtgtgtggag cagctggtgg
       61 agtctggggg aggcttggta cagccggggg cgtccctgag actctcctgt gcagcctctg
      121 aattcacctt cagtagctat gacatgcact gggttcgcca ggctccaggg aagggtctgg
      181 agtggatatc aggtattaac attggcggtg acacatacta cccagactct gtgaagggtc
      241 ggttcaccat ctccagagac aatgccaaga actccttgta tcttcaaatg aacagcctga
      301 gagctgagga cactgctgta tattattgtg caagaggcgt agataaccac cactacagtg
      361 atacggagtt tgacctctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000136             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22890:16269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000136
VERSION     KCXD01000136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22890:16269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58618.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          136 c          145 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggga cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaagaa ccagttctcc ctgaggctga gttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgg cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000137             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21768:19362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000137
VERSION     KCXD01000137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21768:19362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58619.1"
                     /translation="CTRIGVGSLAVAGDYFDSW"
     D_segment       455..463
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          102 a          129 c          159 g          124 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagat ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagtaacac
      301 tggtaaaacc gtgtactact ctgactccgt gaagggccga ttcaccatct ccagagacag
      361 cgccacgaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtacc agaattggcg tcggatctct agcagtggct ggtgactatt ttgactcctg
      481 gggccgggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000138             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16665:4157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000138
VERSION     KCXD01000138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16665:4157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58620.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       399..403
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           95 a          147 c          135 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcagg aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg gatcttgtcc caggtgctac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccctcagc acttactact ggagctggat ccgccaggcc ccagggaagg ggctggagtg
      241 gattggatac atctatgctg atagtgggac caccaactac aacccgtccc tcaagagtcg
      301 agtcaccatt tcagtagaca cgtccaagaa cctgtactcc ctgaatctga gctctgtgac
      361 cgccgcggac acggccttct attactgtgc gagacgtcct actcgcacgc gggttctata
      421 tgaggcgaca ggggaagact ttgactcctg gggccaggga ctcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000139             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18059:9571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000139
VERSION     KCXD01000139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18059:9571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58621.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          136 c          141 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gaatatggtg aaatgacgtt
      301 ccaggggaga gtcaccatga ccgaggacac gtctacagac acggcctaca tggagctgag
      361 tagcctgaga tctgaggaca cgggcgtgta ttactgtgcg attggcccta gcggcaggtg
      421 gaaccactgg tccttcgaga tctggggacc tgggacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000140             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:17753:10590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000140
VERSION     KCXD01000140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:17753:10590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58622.1"
                     /translation="CASADSGYPPYFFDFW"
     D_segment       415..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           83 a          142 c          141 g          115 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgatg tctctggtgg
      181 ctctatcacc agcaccaact ggagctggat ccgccgggcc ccagggaagg gactggagtg
      241 gattgggtgt atctttggtg gtggtatctt tggtggtggt agtaacaccc actacagtcc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagaaccaac tctccctgca
      361 gctgacgtct gtgaccgccg cggacacggc cgtgtatttc tgtgcgagcg ctgatagtgg
      421 ttatcctccc tacttctttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01000141             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10442:4845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000141
VERSION     KCXD01000141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10442:4845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58623.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       442..447
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          126 c          155 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccatt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctaagac tctcctgtga agcctccggg ttcaccttca gtgaccactg
      241 catacactgg gtccgccagg cttcagggaa ggggctggag tgggtctcag gtattactta
      301 tactggtgtt accacatggt acgcagactc cgtgaggggc agattcacca tctccagaga
      361 gaacaccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctatttctgt gtggcaggaa ggcggcacgt ggaccttgac tactggggcc agggagtcct
      481 ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01000142             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13117:7823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000142
VERSION     KCXD01000142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13117:7823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58624.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          141 c          137 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcggc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccaggaaagg ggctggagtg
      241 gattgggttt ttcggtggtt atggtgggag cacctactac aacccctccc tccagagtcg
      301 agtcaccatt tcagccgaca cgtccaaaca ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct actattgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000143             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11459:12462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000143
VERSION     KCXD01000143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11459:12462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..442
     V_segment       88..381
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58625.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       390..395
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           99 a           99 c          138 g          108 t
ORIGIN      
        1 acatggggca cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt
       61 gttgctattt taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg
      121 gttcagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc
      181 tatggcatgc actgggtccg ccaggctcca gggatgggcc tggagtgggt gacggttata
      241 tcgaatgatg gaagtaagaa atactacgca gactctgtga aggaccgatt cagcatctcc
      301 agagacaatt ccaagaacat gctatatctt caaatgaaca acgtgaaatt ggaggacacg
      361 gccgtttatt actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga
      421 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000144             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24833:5761
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000144
VERSION     KCXD01000144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24833:5761"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..477
     V_segment       108..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58626.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       408..418
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           96 a          138 c          141 g          104 t
ORIGIN      
        1 acatgggggg gaaatgttct ctgagagtca cggacatcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag ctgcagctgc
      121 aggagtcggg cccaggactg gtgaagcctt tggagaccct gtccctcacc tgcggtgtct
      181 ctggtggctc catcagcagt aactactgga gctggatccg ccagtcccca gggaagggac
      241 tggagtggat tggacgtatc tctggtagtg gtgggagcac cgtctacaac ccctccctca
      301 agagtcgagt caccatttca acagacacgt ccaagaacca gatctccctg aaagtgacct
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgac agccggatat agcagcagtg
      421 aaagcttcta cggtttggat tcgtggggcc aaggggtcgt cgtctccgtc tcctcagcc
//
LOCUS       KCXD01000145             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16732:13949
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000145
VERSION     KCXD01000145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16732:13949"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58627.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       445..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          111 c          157 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccctca gtaactatgg
      241 catacactgg gtccgccagg ctccagggga ggggctggag tgggtggcag ttatatcgta
      301 tgatggaagt aagaaatatt acgcagactc tgtgaaggac cgattcacca tttccagtga
      361 cagttccaag aacatggcat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagagatg cgtttggttc cggtttggat tcctggggcc tgggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000146             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20299:15126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000146
VERSION     KCXD01000146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20299:15126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58628.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       460..467
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          111 a          134 c          159 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctatgttca gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtc
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat
      241 ggcatgacct gggtccgcca ggctccaggg aaggggctgg agtgggtctc atacattagt
      301 attggtggta gtaatagata ctacgcagac tccgtgaagg gccgattcac catctccaga
      361 gacaactcag agaaaacgct ctccctgcaa atgaacagcc tgagacctga ggacacggcc
      421 gtgtattact gtgcgtcgaa cctacgtgga aacacctaca cttactggcg gtcctttgac
      481 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000147             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:20083:4816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000147
VERSION     KCXD01000147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:20083:4816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58629.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       443..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          111 c          152 g          120 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgcgatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 gaggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttt ctatggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ttcgaatgat
      301 gaaactaaga aatactacgc agactctgtg aaggaccgat tcaccatttc cagagacaat
      361 tccaagaaca tgctatttct tcaaatggac aacctgaaat tggaggacac ggccgtctat
      421 tattgtgtga gagatgattt aggcagcggc ttagggtcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000148             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:3410:11112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000148
VERSION     KCXD01000148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:3410:11112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..505
     V_segment       125..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58630.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       425..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>511
                     /gene="IGHG"
BASE COUNT          115 a          139 c          147 g          110 t
ORIGIN      
        1 acatggggga tcacataaca accacgtccc tcctctaaag aagcccctgg gaacacagct
       61 catcaccatg gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca
      121 gtcccaggtc cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 gctctcctgc aaggcttctg gatacacctt cagcatctct gccatcagtt gggtgcgaca
      241 ggcccctgga caagggcttg ggtggatggg agggatcatc cctcttgttg gtatgacaaa
      301 ctacgaacag aagttccagg gcagagtcac gattaccgcg gacacgtcca cgaatacagt
      361 cttcatggaa ctgagcagcc tgagatctga ggacacggcc gtctactatt gtgcgacagg
      421 ggtatattac caggatgaaa acggttattt ttatgtcggc ggtgactttg actactgggg
      481 ccagggagtc ctggtcaccg tctccccagc c
//
LOCUS       KCXD01000149             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12366:10101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000149
VERSION     KCXD01000149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12366:10101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58631.1"
                     /translation="CATSSSGIWLYWYFDVW"
     D_segment       424..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          142 c          137 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt cagcgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgagatgat
      301 tgacgcagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggtc ctgagcagcc tgagatctga ggacacggcc gtctattact gtgcgacatc
      421 atccagcggc atttggctat actggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000150             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7530:10836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000150
VERSION     KCXD01000150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7530:10836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58632.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       443..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          124 a          114 c          150 g          126 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggaatct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcaatg agtatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg attggttata ttagaagcaa
      301 atataacaat tacgcgacag aatatgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacac tatatctgca gatgagcagc ctgaaaaccg aggagacggc
      421 cgtgtattac tgcacccgtc tctatagtgg gaactataga attatgatgt ttgactactg
      481 gggccaggga gtcctggtca gtgtctcctc agcc
//
LOCUS       KCXD01000151             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12536:6583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000151
VERSION     KCXD01000151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12536:6583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58633.1"
                     /translation="CARWSAANFDSW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           86 a          135 c          136 g          102 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatcc gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg gatgtatcta tgatagtagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaat ggacacgtcc atgaaccagt tctccctgga gctgaggtct
      361 atgaccgccg cggacacggc cgtgtatcac tgtgcgagat ggtcggcagc caactttgac
      421 tcctggggtc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000152             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8357:5121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000152
VERSION     KCXD01000152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8357:5121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58634.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          114 a          143 c          138 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaac cctggggcct cagtgagggt
      181 ctcctgcaag gtttccggat acaccttcac cgagttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcatatggtg aaatgataaa
      301 cgcagagaag ttccagggca gaatcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctgt catctgagga cacggccgtg tatttctgtg cgagtggccc
      421 tagcggcagt tggaacggct ggtacttcga tttctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01000153             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15382:18020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000153
VERSION     KCXD01000153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15382:18020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..481
     V_segment       124..411
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58635.1"
                     /translation="CTYRSSYYYGVESW"
     D_segment       414..418
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..481
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           99 a          140 c          135 g          109 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta ggacttctgg atacaagttc agcagctact ggatcaactg ggtgcgccag
      241 atgcccggaa aaggcctgga gtggatgggg gcgattgatc ctagtgattc tgagaccaga
      301 tacagaccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagtaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gactccgcca cgtattattg tacataccgg
      421 tcttcatatt attacggtgt agagtcctgg ggccaagggg tcgtcgtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000154             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14133:10145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000154
VERSION     KCXD01000154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14133:10145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58636.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          119 c          149 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000155             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22542:7110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000155
VERSION     KCXD01000155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22542:7110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..481
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58637.1"
                     /translation="CARCAEYCTGSGCYVTRFDVW"
     D_segment       402..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..481
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           88 a          137 c          148 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gttgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccgtca gcagtaacta ctggagttgg gtccgccagt ccccagggaa ggggctggag
      241 tggatggggt atataagtgg cggtagtggg ggcaccacct acaatccctc cctcaagagt
      301 cgagtctcct tttcaagaga cacgtccaag agccagcttt ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatgtg cagaatactg tactggaagt
      421 ggttgctatg tcacccggtt cgatgtctgg ggcccgggag tccgggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000156             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19102:18948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000156
VERSION     KCXD01000156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19102:18948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58638.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       443..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          112 c          151 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcacc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt agttatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgtaagtaa gaaatactac gcagacgctg tgaatgaccg attcaccatc tccagagaca
      361 attccaagaa caccctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgg gagagatgat aatggggtgc ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000157             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14986:3095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000157
VERSION     KCXD01000157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14986:3095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..429
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58639.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       440..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          102 a          126 c          154 g          115 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc cagaattccc aggtgtttct gttcggcgat
       61 cagcactaaa cacagaacac accatggagt ttgtgctgag ctgggttttc cttgttgctc
      121 ttttgaaagg tgtccattgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctaagactc tcctgtgaag cctccgggtt caccttcagt gaccactgca
      241 tacactgggt ccgccaggct tcagggaagg ggctggagtg ggtctcaggt attacttata
      301 ctggtgttac cacatggtac gcagactccg tgaggggcag attcaccatc tccagagaga
      361 acaccaagaa cacactgtat cttcaaatgg acagcctgag agctgaggac acggctgtct
      421 atttctgtgt ggcaggaagg cggcacgtgg accttgacta ctggggccag ggagtcctgg
      481 tcgccgtctc ctcagcc
//
LOCUS       KCXD01000158             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18980:8818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000158
VERSION     KCXD01000158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18980:8818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58640.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       440..448
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          109 c          155 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcagct tcagtatctt tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatgtc gaatgatgga
      301 agtaagaaat actacacaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaaaatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattat
      421 tgcgcgagag acgattttgg cagcggctta gggtactggg gccagggagc cctggtgacc
      481 gtctcttcag cc
//
LOCUS       KCXD01000159             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7139:5020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000159
VERSION     KCXD01000159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7139:5020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58641.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       441..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          128 c          153 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatt
      241 ctatacactg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattagta
      301 ctgctgggac cacatattac acagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccctgt
      421 attactgtgc gaaaggggag acagcttcag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01000160             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21730:14291
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000160
VERSION     KCXD01000160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21730:14291"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58642.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       445..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          127 c          151 g          114 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccattgtg aggtgcagct ggtggaatct gggggcggct tggcaaagcc
      181 tggggggtcc ctaagactct cctgtgcagc atccggattc accttcagtg accactgcat
      241 gcactgggtc cgccaggctt cagggaaggg gctggagtgg gtctcaggta ttacttatac
      301 tggtgttacc acttgggacg cagactccgt gaggggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcacatgga cagcctgaga cctgaggaca cggctgtcta
      421 ttactgtgtg acaggaaggc gacacgtgga ccttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000161             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13892:5923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000161
VERSION     KCXD01000161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13892:5923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58643.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       241..246
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           74 a           67 c           87 g           70 t
ORIGIN      
        1 acatggggca gcctctggat tcagcttcag tggctttggc atgcactggg tccgccaggc
       61 tccagggaag ggggtggagt gggtggcagt tatatcgtat gatgaaacta agaaatatta
      121 cgcagactct gtgaaggacc gattcaccgt ctccagagac aattccaaga acatgctata
      181 ttttcaaatg aacaacctga aattggaaga cacggccgtg tattactgtg cgagagatgt
      241 ctatggcagg ggacttgact actggggcct gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000162             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:26145:18103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000162
VERSION     KCXD01000162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:26145:18103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58644.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       455..462
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          123 c          159 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcaacttc aattactact
      241 acatgaactg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaca
      301 gtggtgggga tagcacctac tatgcggact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgac gacacggctg
      421 tctattactg tgcgagagtg gtgggtggtg ccgcaggata tttcgacttc tggggccagg
      481 gcgcactggt caccgtctcc tcagcc
//
LOCUS       KCXD01000163             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19860:3356
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000163
VERSION     KCXD01000163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19860:3356"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..488
     V_segment       113..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58645.1"
                     /translation="CSRGSNYEDAYDYFSAFDSW"
     D_segment       414..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          109 a          135 c          139 g          107 t
ORIGIN      
        1 acatgggaac cacgtccctc ctctaaagaa gcccctggga acacagctca tcaccatgga
       61 cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt cccaggtcca
      121 gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc tctcctgcaa
      181 ggcttctgga tacaccttca gcatctatgc catcaattgg gtgcgacagg cccctggaca
      241 agggcttgag tggatgggag ggatcatccc tcttgttggt ataacaaact acgtacagaa
      301 gttccagggc agagtcacga ttaccgcgga cacgtccaca agcatagcct acatggagct
      361 gagcggccta agatctgagg acacggccgt gtattactgt tcgagagggt caaattacga
      421 ggatgcttac gattactttt ctgcctttga ctcctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000164             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16244:20480
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000164
VERSION     KCXD01000164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16244:20480"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..339
     V_segment       6..253
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58646.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       291..297
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..339
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           76 a           83 c          105 g           77 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctccgg attcaccttc agtgactact
       61 atatggactg ggtccgccag gctccaggga aggggctgga gtgggtctca cgaatcggtc
      121 atgatggtgg tagcacatgg tacgcagact ccgtgaaggg cagatttacc atttccagag
      181 agaatgccaa gaacacactg tttcttcaaa tggacagcct gagaagtgag gacacagccg
      241 tatattactg tgccagagag cggtttgggg gaattggggt aattatcttc aactggatcg
      301 atgtctgggg cccgggagtc ctggtcaccg tcccctcagc c
//
LOCUS       KCXD01000165             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4460:20250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000165
VERSION     KCXD01000165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4460:20250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..460
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58647.1"
                     /translation="CARNRFMGVRVLAYW"
     D_segment       399..403
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           93 a          137 c          131 g          101 t
ORIGIN      
        1 catgggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtccagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagcg gttactactg gaactggatc cgccaaccac cagggaaggg cctggagtgg
      241 attgggtata tcgctggtag tagtgggagc accgactaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagagc caattctccc tgaagctgaa ctctgtgacc
      361 gccgcggaca cggccatcta ttactgtgcg agaaatagat ttatgggtgt aagggttctt
      421 gcctactggg gccagggagt cctggtcgcc gtctcctcag cc
//
LOCUS       KCXD01000166             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14366:13053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000166
VERSION     KCXD01000166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14366:13053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..492
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58648.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       431..441
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>496
                     /gene="IGHG"
BASE COUNT          116 a          142 c          142 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggctggg aggtgttgat cttgcatatg atgaaataat
      301 acacgcagag aagttccaag gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcggcggg
      421 ccttggggga tatttactgc tcactgaata cctcgagttc tggggccagg gcgccctggt
      481 caccgtctcc tccgcc
//
LOCUS       KCXD01000167             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5663:12548
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000167
VERSION     KCXD01000167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5663:12548"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..492
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58649.1"
                     /translation="CAAGRGGYLLLTEYFQFW"
     D_segment       429..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>496
                     /gene="IGHG"
BASE COUNT          117 a          139 c          139 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 gtctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgatttg tccatccact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggttggg aagtgttgat tatgaatatg atgaaataat
      301 actcgcagac aatttccagg gcagagtcac catgaccgag gacacgtcca gagacacagc
      361 ctacatggac ctgagcagcc tgaaatctga ggacacggcc atatatttct gtgcggcggg
      421 ccgtgggggg tatttactgc taactgaata tttccaattc tggggccagg gcgccctggt
      481 caccgtctcc tccgcc
//
LOCUS       KCXD01000168             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20645:19765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000168
VERSION     KCXD01000168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20645:19765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58650.1"
                     /translation="CARVTGIDESSVEYFEFW"
     D_segment       438..444
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..507
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          118 a          119 c          150 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccagtctcca gggcaggggc tggaatgggt ggcacttata tcgtatgatg
      301 gaactaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agtaaccggt atagatgaaa gttccgttga atacttcgag ttctggggcc
      481 agggcgccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000169             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15173:19142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000169
VERSION     KCXD01000169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15173:19142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58651.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          118 c          164 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga ttgggtctca ggtgttaata
      301 gtggtgggga tagcacatac tacgcagact ccgtgaaggg ccgattcacc atgtccagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggcg gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000170             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16829:15093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000170
VERSION     KCXD01000170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16829:15093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58652.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT           97 a          125 c          160 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggcgg cctggcttgg
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag ttactactac
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtgggggta gcacattcta tgcagactcc gtggagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgtc tcttcacatg gacggcctga gacctgagga ctcggctgtt
      421 tattactgtg cgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000171             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23707:3615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000171
VERSION     KCXD01000171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23707:3615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58653.1"
                     /translation="CAREYCTSESCAGFFDYW"
     D_segment       418..425
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          119 a          137 c          136 g          103 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc acttggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccctc gacaactatg gaatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccttgtcgg tatagtgaac
      301 tacgtagaga acctccaggg cagagccatc ataaccgcgg acacgtcaac aaacacagtc
      361 tacatggaac tgaacagcct gagatctgac gacacggcca tctatttctg tgcgagagaa
      421 tactgcactt ctgaaagttg cgccggattc tttgactact ggggccaggg agtcctggtc
      481 accgtctctt cagcc
//
LOCUS       KCXD01000172             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8625:17295
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000172
VERSION     KCXD01000172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8625:17295"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..478
     V_segment       118..408
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <400..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58654.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       412..423
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..478
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          101 a          130 c          143 g          106 t
ORIGIN      
        1 acatggggga agtccacagt gttccattcg gtgatcagca ctgaacacag aggactcacc
       61 atggagtctg ggctgagctg ggttttcctt gttgctattt taagaggtgt ccagtgcgag
      121 gtgcacctgg tggagtctgg gggcggcctg gcaaagcctg ggggagccct gagcctctcc
      181 tgtgcagcct ctggattcac cttcagtacc tatgctatgc actgggtccg ccaggctcca
      241 gggaaggggc tggaatgggt ctcagctatt agtagtggtg gcaccacata ctacgcagac
      301 tccgtgaagg gccgattcac cgtctccaga gacaactcaa agaacacgct ctccctgcaa
      361 atgaacagcc tgagagctga ggacacggcc gtgttttact gtgcgaaagc cgatacagct
      421 acaccatact acggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000173             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17453:21172
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000173
VERSION     KCXD01000173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17453:21172"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58655.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       419..434
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          101 a          143 c          128 g          106 t
ORIGIN      
        1 acatgggggg tctccctcac cgcacagctg ggatctcagt tcttcatttc tgtcctccac
       61 cacgatgggg tcaactgcca tcctcgccct cctcctggct gttctccaag gagtctgtgc
      121 cgaggtgaaa ctggtgcagt ctggggcaga ggtgagaagg cccggggagt ctctgaagat
      181 ctcctgtaag acttctggat acagctttac caccaactgg atcagttggg tgcgccagac
      241 gcccggaaaa ggcctggaat ggatggggac catctatcct gctgattctg aggccaaata
      301 caacccgtcc ttccaaggcc acgtcactat ctcagccgac aagtccatca gtaccaccta
      361 cctgcagtgg agcagcctga aggcctcgga caccgccacg tatttctgtg cgaaaaccta
      421 ctatagtggt agtttggaaa tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000174             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18347:13145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000174
VERSION     KCXD01000174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18347:13145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58656.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       441..449
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          113 c          156 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccacacgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctttttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg gggctctcct gtgcagcctc tggattcacc ttcagtcact atggcgttca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtatgatga
      301 aaataagaaa tactacgcag actctgtgag ggaccgattc accatctcca gagacaattc
      361 caagaccatg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtattt
      421 ctgtgtgaga gatgtcagag gcggtggctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000175             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15224:16142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000175
VERSION     KCXD01000175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15224:16142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..507
     V_segment       126..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58657.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       428..451
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          141 c          146 g          106 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagttggtg cagtccgggg ctgaggtgaa gaggcctggg gcctcagtga
      181 agctctcctg caaggctcct ggatacatct tcagtatatc tgccatcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagggatcat ccctcttgtt ggtgtaacaa
      301 ccaacgcaca gaagttccag gacagagtca cgattaccgc ggacacgtcc acaagcacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgagtg
      421 gcggcttcga ggatgataac ggtcactatt atacgacact aacatttcac gattggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000176             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13720:3281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000176
VERSION     KCXD01000176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13720:3281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58658.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          114 a          146 c          130 g           91 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtgga
      301 ctacacacag aacttccgag acagactcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01000177             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13127:10862
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000177
VERSION     KCXD01000177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13127:10862"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58659.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       436..443
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          142 c          138 g          102 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggttaagaag cctggggcct cagtgagggt
      181 ctcctgccag gtttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgatcct gtaaatggtg aaataataca
      301 cgcagacaac ttccagggca gagtcaccat gaccgaagac acgtctatag acacagccta
      361 catggaactg agcagcctga gatctgagga tacggccgta tattactgtg cgacccacgg
      421 aggctatagt gacatctgga actccctgta ctacggtttg gattcctggg gccaaggggt
      481 cttcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000178             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12648:5202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000178
VERSION     KCXD01000178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12648:5202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58660.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       437..443
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          110 c          150 g          116 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gaagcctctg gattcacctt cagtagttat ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg tatgatgtaa
      301 gtaagaaata ctacgcagac gctgtgaagg accgattcac catctccaga gacaattcca
      361 agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtgtattact
      421 gtgggagaga tgataatggg gtgcttatcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01000179             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20030:6554
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000179
VERSION     KCXD01000179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20030:6554"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..491
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58661.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       418..432
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          140 c          141 g          102 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggatcca ccttcaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgctcctcta tatggtgaaa tgatgcacgc
      301 agacaacttc cagggcagag tcaccttgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgacgacac ggccgtgtat tactgtgcgc gtgggcctat
      421 tacaattttt ggcgtactta ttacggggct tgactattgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000180             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20820:18869
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000180
VERSION     KCXD01000180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20820:18869"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..445
     V_segment       76..372
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58662.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       383..397
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..445
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           90 a          107 c          138 g          112 t
ORIGIN      
        1 acatggggga gactcatcat ggagtttggc ctgagctggg ttttccttgt tgctatttta
       61 aaaggtgtcc agggtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      121 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgacta ctggatgtac
      181 tgggttcgcc agacacctga gcgggggctg gagtggctct cagctattga tagtgctggt
      241 actagtacca catactatgc agactccgtg aagggcagat tcaccatctc cagagagaac
      301 gccaaaaaca cactgtatct tcagatggac agcctgagaa ctgaggacac ggctgtctat
      361 tactgtgcga gagttccggg cctagtggta tttactggtt cgcttgacta ctggggccag
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000181             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7244:3955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000181
VERSION     KCXD01000181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7244:3955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..469
     V_segment       100..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58663.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       410..419
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           94 a          144 c          135 g           98 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggctc
       61 ttcctcctgc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagtc ctcagagacc ctgtccctca cctgcgctgt ctctggtgcc
      181 tccatcggta gttactggtg gacctggatc cgccagcccc cagggaaggg actggagtgg
      241 attggggaga tcaatggaaa tagcggtagt acctactaca gcccctccct caagagtcga
      301 gtcaccattt caaaagacgc gtccaagaac caccactccc tgaagctgaa ctctgtgacc
      361 accgcggaca cggccgtgta tttctgtgcg aacgtcttag gcccctgggg cagctggtca
      421 cactactttg agtactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000182             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15528:9194
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000182
VERSION     KCXD01000182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15528:9194"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58664.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       416..425
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          106 a          147 c          137 g          101 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtaca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc aacatctatg ccatcaattg ggtgcgacag gcccctggac
      241 aggggcttga gtggatggga gggatcatcc ctcttgttga tatgacaaac tacgcacaga
      301 ggttccaggg cagagtcacg attaccgcgg acacgtccac agccacagcc ttcttggaac
      361 tgagcagcct gagatctgac gacacggcca tttattactg tgcgagagcc cgggcctacg
      421 gtagcggcta ccgctcagac tggttcttcg atgtctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000183             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6748:14153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000183
VERSION     KCXD01000183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6748:14153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58665.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          143 c          135 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaactgca ggcgcccgct
      121 ctgaggtcca gctggtgcaa tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 ccccaggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acggagaaaa attccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagtctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcac ctggctattt tggtacttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000184             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11133:4287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000184
VERSION     KCXD01000184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11133:4287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58666.1"
                     /translation="CARGKGFILYYFDYW"
     D_segment       441..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          121 a          112 c          148 g          123 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcagtttcag tagctatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtgacact tatatcgaat
      301 gatggaagta agaaagacta tgaagactct gtgaaggacc gattcatcat ctccagagac
      361 aattccaaga acatactata tcttcaaatg aacaacctga aattggatga cacggccgta
      421 tattactgtg cgagaggaaa aggattcatt ctgtactact ttgactactg gggcctggga
      481 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01000185             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27716:11943
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000185
VERSION     KCXD01000185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27716:11943"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58667.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          146 c          142 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actttgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caacttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgacatctg aggacacggc catctactac tgtgcgacag
      421 ggaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01000186             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18818:12512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000186
VERSION     KCXD01000186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18818:12512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58668.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          123 c          147 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttcctttg
      241 gcatgcactg ggtccgccag gcaccgggga aggggctgga gtgggtggca gttttatcgt
      301 ctgatggaac taacaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag
      361 acaactccaa gaacatacta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01000187             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13377:12681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000187
VERSION     KCXD01000187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13377:12681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58669.1"
                     /translation="CARDQPYKISGDEYGLHSW"
     D_segment       422..434
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..476
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          139 c          136 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 cgccatcagc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatatctttg gtgctactgg aaacacctac tacagccgtt ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggcca tttattactg tgcgagagac caaccttaca aaatttctgg
      421 agatgaatac ggtttgcact cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01000188             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11778:10193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000188
VERSION     KCXD01000188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11778:10193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..501
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58670.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       421..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>507
                     /gene="IGHG"
BASE COUNT          113 a          138 c          146 g          110 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctctgcca tcagttgggt gcgacaggcc
      241 cctggacaag gacttgggtg gatgggaggg atcatccctc ttgttggtat gacaaactac
      301 gaacagaagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      361 atggaactga gcagcctgag atctgaggac acggccgtct actattgtgc gacaggggta
      421 tattaccagg atgaatacgg ttatttttat gtcggcggtg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01000189             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:27796:8889
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000189
VERSION     KCXD01000189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:27796:8889"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..481
     V_segment       115..408
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58671.1"
                     /translation="CARVGEDTGGAEDFDFW"
     D_segment       420..426
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          108 a          109 c          147 g          119 t
ORIGIN      
        1 acatgggagt ccacagtgtt ccattcggtg atcagcacag aacacagagg actcaccatg
       61 aagtttgggc tgagctgggt tttccttgtt gctattttaa gaggtgtcca gtgtgaggta
      121 caactggtgg agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt
      181 gcagcctccg gattcacctt cagtagcttt ggcatgcact gggtccgcca ggctccaggg
      241 aagggactgg agtgggtggc actgatatcg tatgatggaa gtaagaaata ttacgcagac
      301 tctgtgaagg accgattcac cctctccaga gacaattccg agaacatcct atatcttcaa
      361 atgaacaacc tgaaattgga ggacacggcc gtgtattttt gtgcgagagt tggagaggat
      421 actggtggtg cggaggactt tgacttctgg ggccagggag ccctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000190             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9692:15557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000190
VERSION     KCXD01000190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9692:15557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58672.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          112 a          141 c          132 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga aatgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgtgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000191             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:7538:10917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000191
VERSION     KCXD01000191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:7538:10917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..508
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58673.1"
                     /translation="CATGIYYQDEYGSFSIGGDFDSW"
     D_segment       424..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          111 a          142 c          145 g          112 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcctctgg atacaccttc agcatctctg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttgg gtggatggga gggatcatcc ctcttgttgg tatgacaaac
      301 tacgaacaga acttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc
      361 ttcatggagc tgagcggcct gagatctgag gacacggccg tctattattg tgcgacaggg
      421 atatattacc aggatgaata cggttctttt tctatcggcg gtgactttga ctcctggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000192             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16233:5053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000192
VERSION     KCXD01000192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16233:5053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58674.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          125 c          158 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagatact
      241 ggatgaactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattacta
      301 gtggtggaga tagtacgtac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct tagagcggag gacacggccg
      421 tgtattactg tgcgaacgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000193             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:24347:19269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000193
VERSION     KCXD01000193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:24347:19269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58675.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       413..422
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          144 c          135 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ctcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccctcagag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatcg gtagttactg gtggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg aaatagtggt agtacctact atagcccctc cctcaagagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccacctct ccctgaagct gaactctgtg
      361 accaccgcgg acacggccgt gtatttctgt gcgaacgtct taggcccctg gggcagctgg
      421 tcacactact ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000194             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20272:3079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000194
VERSION     KCXD01000194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20272:3079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58676.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       443..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          108 c          154 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt cagtttcagt aattatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcagtt atgtcatctg
      301 atggaactaa gaaattctac gcagactctg tgaaggtccg attcaccatc tccagagaca
      361 attccaagaa catggtatat cttcaaatga acagcctgaa atcggaggac acggccgtat
      421 attattgtgg gagagatgat aatggggtga ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtcac ctcagcc
//
LOCUS       KCXD01000195             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21058:7066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000195
VERSION     KCXD01000195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21058:7066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..484
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58677.1"
                     /translation="CARHRTSDYYSGSYPNPFRSFDFW"
     D_segment       408..427
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>490
                     /gene="IGHG"
BASE COUNT           96 a          151 c          137 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggagaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtac atcaatggtg ctagtgggag caccacccac aacccgtccc tccagagtcg
      301 agtcaccatt tccattgaca cgtccgagaa ccagttctcc ctgaggctga actctataac
      361 cgccgcggac acggccgtgt attactgtgc gagacatagg acgtcggatt actatagtgg
      421 cagttatcca aaccccttcc gctcctttga cttctggggc cagggagtcc tggtcaccgt
      481 ctccccagcc
//
LOCUS       KCXD01000196             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13192:11960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000196
VERSION     KCXD01000196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13192:11960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..469
     V_segment       106..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58678.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       411..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           96 a          131 c          140 g          104 t
ORIGIN      
        1 acatggggga aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctccg gagaccctgt ctctcacctg cggtgtctct
      181 ggtggctcta tcagcagtag ttactgcagc tggatccgcc agaccccagg gaagggactg
      241 gagtggattg ggtatatcta tgggagggat agtagtacca agtacaaccc ctccctcaag
      301 agtcgagtca ccctgtcagt agacacgtcc aagaaccagt gctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgagtt cgggtataga agtggttgcc
      421 tacagcattg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000197             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16584:7337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000197
VERSION     KCXD01000197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16584:7337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58679.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       404..418
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          137 c          127 g          110 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacatgcgc tgtctctggt
      181 gactctatca gcagtagtca ctggtggagc tggatccgcc agcccccagg gaaaggcctg
      241 gagtggattg gctatatcag tggtagtggt gataacacct actacaaccc ctccctcaag
      301 aatcgagtca ccttttcaac agtcacgtcc aagaaccagt tctcccttaa gctgagctct
      361 gtgaccgccg cggacacggc catgtattac tgttcgaggg tgcgtggata caactacatt
      421 ttatttgact cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000198             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11907:17836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000198
VERSION     KCXD01000198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11907:17836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58680.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       263..268
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       272..318
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           74 a           74 c           97 g           75 t
ORIGIN      
        1 atgggggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
       61 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      121 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggtg gatacggcca
      241 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      301 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000199             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9944:17712
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000199
VERSION     KCXD01000199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9944:17712"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..504
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58681.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       446..455
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          118 c          154 g          121 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagccggggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtttt ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc acttatctcg tttgatggaa
      301 ctaagcaatt ctacgcagac tctgtgaagg accgattcac catttccaga gacaattcca
      361 agaacatgct atatctccaa atgaacaacc tgaaattggg ggacacggcc gtacattact
      421 gtgcgagagt tagtgggcat acggagggta cagttgaata ctttgactac tggggccagg
      481 gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000200             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18615:18848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000200
VERSION     KCXD01000200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18615:18848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58682.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       452..467
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          121 c          152 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttcctttttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtggctatg
      241 gcatgcactg ggtccgccag gctccaggga cggggctgga gtgggtggcc cttatctcct
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatccta tatcttcaag tgaacaacct gacattggag gacacggcca
      421 tgtatttctg tgcgagagtg gggacatatg atagtggtta ttacaccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000201             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:26767:14406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000201
VERSION     KCXD01000201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:26767:14406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58683.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          101 a          122 c          159 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtcgggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact acttcatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atagtggtgg
      301 ggatgataca tactatgcag actccgtgaa gtgccgatcc accttgtcca gagagaacgc
      361 caagaacaca ctgtatcttc acatggtcag cctgagaggt gaggacacgg ctgtctatta
      421 ctgtgcgaga gaccgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000202             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20996:20032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000202
VERSION     KCXD01000202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20996:20032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..395
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58684.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       402..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           92 a          135 c          129 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaaa tgggtcctgt cccagctaca attgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gcatttacta ctggaattgg atccgccagg ccccagggaa gggactggac
      241 tggattggac atatctatgg tagcggtgat agcaccaact tcaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagttct ccctgaacct gaggtctgtg
      361 accgccgcgg acacggccgt atattactgt gcgagcggtc ggcggcagct ggactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000203             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8534:17196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000203
VERSION     KCXD01000203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8534:17196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58685.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       453..460
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          110 a          133 c          156 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggagacttg gtccagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcatacatt agtattggcg
      301 gtggtaggat atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 cagagaaaac gctctccctg caaatgaaca gcctgagacc tgaggacacg gccgtatatt
      421 actgtgcgtc gaacctacgt ggaaacacct acacttactg gcggtccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000204             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:8560:17320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000204
VERSION     KCXD01000204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:8560:17320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    97..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        97..454
     V_segment       97..390
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58686.1"
                     /translation="CARYEAGTTLIDYW"
     D_segment       396..407
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           91 a          138 c          129 g           98 t
ORIGIN      
        1 acatggggtc tgagagtcat ggacctcctg tgcaagaaca tgaagcacct gtggttcttc
       61 cttctcctgg tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc
      121 ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc tggtgactcc
      181 gtcaccagca cctactggag ctggatccgc cagcccccag ggaaaggact ggagtggatt
      241 ggctatatct atggtggtag tgggagtacc ggctacaacc cctccctcag gagtcgagtc
      301 gacatttcga cagacacgtc caacaaccag ttttccctga agctgagctc tgtgaccgcc
      361 gcggacaccg ccgtctacta ctgtgcgaga tatgaagctg gaacaaccct aattgactac
      421 tggggccagg gagtcctggt catcgtctcc tcagcc
//
LOCUS       KCXD01000205             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10531:11785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000205
VERSION     KCXD01000205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10531:11785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58687.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       403..417
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           93 a          137 c          128 g          109 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacatgcgct gtctctggtg
      181 actctatcag cagtagtcac tggtggagct ggatccgcca gcccccaggg aaaggcctgg
      241 agtggattgg ctatatcagt ggtagtggtg ataacaccta ctacaacccc tccctcaaga
      301 atcgagtcac cttttcaaca gtcacgtcca agaaccagtt ctcccttaag ctgagctctg
      361 tgaccgccgc ggacacggcc atgtattact gttcgagggt gcgtggatac aactacattt
      421 tatttgactc ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000206             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:19345:8515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000206
VERSION     KCXD01000206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:19345:8515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58688.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          140 c          152 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgagatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000207             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19941:9849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000207
VERSION     KCXD01000207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19941:9849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58689.1"
                     /translation="CATGYSGTWTNWYFDFW"
     D_segment       417..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          138 c          139 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcggccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca gcgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa cgggcttgaa tggatgggaa gtgttgatcc tgtatatggt gaaatgataa
      301 acgcagagaa gttccagggc agagtcacca tgaccgacga tacgtctaca gacacagcct
      361 acttggagct gagcagcctg agatctgagg acacggccgt gtattactgt gcgaccgggt
      421 atagcggcac ctggaccaac tggtacttcg atttttgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000208             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20491:19383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000208
VERSION     KCXD01000208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20491:19383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58690.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          151 c          131 g           91 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtctccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacgt
      301 tccagggcag agtcatcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac acggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gcccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000209             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19969:9423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000209
VERSION     KCXD01000209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19969:9423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58691.1"
                     /translation="CARPRSIGVRYLGYW"
     D_segment       417..422
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           93 a          140 c          136 g           94 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 ctccctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggg ctggtgaagc cctcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc ggttactact ggaactggat ccgccaacct ccagggaagg ggctggagtg
      241 gattggatat atcggtggga gtagtgggat cacctactac aacccctccc tcaagagtcg
      301 agtcaccatc tcaacagaca cgtccaagaa ccagttctcc ctgagactga cctctgtgac
      361 cgtcgcggac acggccgtat attactgtgc gagaccaagg agcatagggg tgcgatacct
      421 gggctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000210             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18683:17599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000210
VERSION     KCXD01000210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18683:17599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58692.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          142 c          134 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggacc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatgtctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01000211             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18956:20362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000211
VERSION     KCXD01000211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18956:20362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..471
     V_segment       117..410
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58693.1"
                     /translation="CARADRGSSIDFW"
     D_segment       418..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT          110 a          109 c          136 g          118 t
ORIGIN      
        1 acatggggaa gtccacagtg ttccattcgg tgatcagcac agaacacaga agactcacca
       61 tgaagtttgg gctgagctgg gttttccttg ttgcaatttt aagaggtgtc cagtgtgagg
      121 tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg ggggtcccta agactctcct
      181 gtgcagcctc tggattcacc ttcagtacct atggcatgca ctgggtccgc caggctccag
      241 ggcaggggct ggagtgggtg gcggttatat cttatgatga tgataagaaa tactacacag
      301 actctttgaa ggaccgattc accatatcca gagacaattc caagaacact ctttatcttc
      361 aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta ttgtgcgaga gcggatcgcg
      421 gcagttcaat tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000212             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22370:11053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000212
VERSION     KCXD01000212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22370:11053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..510
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58694.1"
                     /translation="CARVTGIDGTTVEYFDFW"
     D_segment       441..456
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..510
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          119 c          157 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 caacagaaca cagaggactc accatgaagt ttgggctgag ctgggttctc cttgtcgcta
      121 ttttaagagg tgtccaatgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagagtc tcctgtgcgg cctctggatt caccttcagt agctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcatctg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat gttcagatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagagtaacc ggtatagatg gaactaccgt tgaatacttc gatttctggg
      481 gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000213             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13712:9871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000213
VERSION     KCXD01000213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13712:9871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58695.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 accctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag ggtccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taggacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaatttcaa gaacatgata tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000214             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11283:19744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000214
VERSION     KCXD01000214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11283:19744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..445
     V_segment       94..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58696.1"
                     /translation="CASGSRRQPDKW"
     D_segment       396..403
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..445
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           85 a          134 c          139 g           89 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagagcatga agcacctgtg gttcttcctc
       61 ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcggttact ggtggggctg gatccgccag cccccaggga aggggctgga gtggattgga
      241 tatatcggtg gaactagtgg gagcacctac tacaacccct ccctcaagag ccgagtcacc
      301 atttcaacag acacgtccaa gaaccaggtc tccctgaagt tgatcactgt gaccgccgcg
      361 gacacggccg tgtattactg tgcgagtgga agtcggcggc agccggataa atggggccag
      421 ggcctcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000215             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23601:9575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000215
VERSION     KCXD01000215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23601:9575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58697.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       409..417
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           95 a          132 c          136 g          115 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 aggctctctc agcggtggtt atgactggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt ggctatatct atggtgctag ggggagcacc acctacaacc cgtccctcag
      301 gaatcgagtc accatttcaa aagacacgtc caagaaccag ttgtccctga agttgagttc
      361 tgtgaccgcc gcggacacgg ccgtatatta ttgtgcgaga cagtgctgtt attatgatga
      421 ctttttagac tactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000216             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23914:8866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000216
VERSION     KCXD01000216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23914:8866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58698.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       414..433
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..495
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          106 a          140 c          145 g          106 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtctcagg
      121 tccagctggt gcagtccggg gctgagatgg agaagcctgg ggcctcagtg aagctctcct
      181 gtaaggcttc tggatacacc ttgagcatct atgtcatcag ttgggtgcga caggcccctg
      241 gacaagggct tgagtggatg ggaggcatct tccctcttgt tggtacaaca aactacgcac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacaagcaca gcctacatgg
      361 acctgagcag cctgggatct ggggacacgg ccgtctatta ttgtgcgaga ggctactgta
      421 ctggtagtgg ttgtaacctt acattcaacc ggctcgatgt ctggggcccg ggagtcccgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000217             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8813:13806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000217
VERSION     KCXD01000217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8813:13806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58699.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          103 a          143 c          127 g          106 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctcagccaa caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000218             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21859:16736
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000218
VERSION     KCXD01000218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21859:16736"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..260
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58700.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       264..275
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           75 a           81 c           94 g           73 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact
       61 atggcatgca ctgggtccgc caggctccag ggaagggtct ggagtgggtg gcagttatgt
      121 cgcatgatgg aactaagaaa ttctacgcag actctgtgaa ggaccgattc accatctcca
      181 gggacaattc caagaacatg gtatatcttc aaatgaacaa cctgagattg gaggacgcgg
      241 ccgtctatta ttgtgcgaga ggagactacg gtaacagcct tgacttctgg ggccagggag
      301 tcctgctcac cgtctcctca gcc
//
LOCUS       KCXD01000219             390 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13102:3549
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000219
VERSION     KCXD01000219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 390)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 390)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13102:3549"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    34..388
                     /note="immunoglobulin heavy chain variable region"
     V_region        34..388
     V_segment       34..325
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <319..>357
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58701.1"
                     /translation="CATDARGSGLDSW"
     D_segment       332..336
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       342..388
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        389..>390
                     /gene="IGHG"
BASE COUNT           81 a           89 c          128 g           92 t
ORIGIN      
        1 acatggggct ctctgtctgc aggtgtccag tgtgaggtgc agctggtgga gtctggagga
       61 ggcttggttc agcctggggg gtccctgaga ctctcctgtg taggctctgg attcacgttc
      121 agtagctatg gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca
      181 gttatatcgt ctgatgggag taagaaatac tacgcagact ctgtgaagga ccgattcacc
      241 atctccagag acaatttcaa gaacatactg tatcttcaaa tgaacagcct gaaaatggaa
      301 gacacggccg tgtggtactg tgcgacagat gcgaggggtt ccggtttgga ttcctggggc
      361 caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000220             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11517:14066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000220
VERSION     KCXD01000220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11517:14066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58702.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          135 c          128 g          111 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagtt acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gatttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactat
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000221             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24254:14876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000221
VERSION     KCXD01000221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24254:14876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58703.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       448..460
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          105 a          120 c          158 g          129 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga atctgggggc ggcttggcta
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccctc agtaactact
      241 ggatgtactg ggttcgccag gctccaggga gggggctgga gtggatctca gctcttaata
      301 gtgttggtga tagtacatac tatgcagact ccgtgaaggg cagattcacc atttccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacgcggctg
      421 tctattactg tgcgagagtt ccgggcctag tggtatttac cggttcgctt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000222             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16836:12146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000222
VERSION     KCXD01000222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16836:12146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..473
     V_segment       107..398
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58704.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       404..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          142 c          132 g          109 t
ORIGIN      
        1 acatgggggc tgtctgagag tcagggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag gtcccagatg ggtcctgtcc cagccgcagc tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcgcct gcgttgtctc
      181 tggtggctcc atcagcgatt actcctggag ctggatccgc cagcccccag ggaagggact
      241 ggagtggatt gggaatattg atgttcatct tgcgggcccc aactacaacc cctccctcaa
      301 gagtcgagtc gccatttcaa aagacacgtc caagaatcag ttctccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtatattt ctgtgcgaaa caatatagtg gtagttatta
      421 ctactcccac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000223             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22192:3910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000223
VERSION     KCXD01000223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22192:3910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58705.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          113 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcgt
      301 atgatggaag ttggaagtac tacggagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagaggg gaatacagta actctgttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000224             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:27720:10391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000224
VERSION     KCXD01000224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:27720:10391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58706.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       426..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          147 c          143 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagcc accggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagttaa gaagcctggg gcctcagtgg
      181 tggtctcctg ccaggtttcc ggatacaccg tcaccgaaat ttccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttgc tcctgaaaaa aatgagttaa
      301 tacacgcaga caagttccag gacagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtggc ctgacatctg aggacacggc cgtgtattac tgtgcgaccc
      421 acggagggta tagcgacatc tggaactccc tatatcacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01000225             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11555:8365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000225
VERSION     KCXD01000225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11555:8365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58707.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       447..457
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          110 a          131 c          152 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggctgggtcc
      181 agcctggggg gtccctgaga ctctcctgta cagccactgg attcaccttc agtagttttg
      241 gcatgagctg ggtccgccag cctccaggga aggggctgga gtgggtctca tacattagta
      301 atagtggtag tagcacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct gacagctgag gacacggccg
      421 tgtatcactg tgcgaaacat cgtttcagca gctggtcgta tttccttgac ttctggggcc
      481 agggaatcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01000226             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18377:15706
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000226
VERSION     KCXD01000226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18377:15706"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..468
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58708.1"
                     /translation="CARDDDDYVYYYYFDYW"
     D_segment       404..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>472
                     /gene="IGHG"
BASE COUNT           92 a          139 c          136 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc gacagtaaat actggagctg gatccgccag tccccaggga aggggctgga
      241 gtggattgga cgtgtctctg gtggtggtgg gaccaccgac tacaacccct ccctccagag
      301 tcgagtcacc atctcaaaag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagggac gacgatgatt acgtttacta
      421 ttattacttt gactactggg gcccgggagt cctggtcacc gtctcctcgg cc
//
LOCUS       KCXD01000227             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22456:13839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000227
VERSION     KCXD01000227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22456:13839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58709.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       356..368
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       369..410
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           89 a           87 c          130 g          106 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tgaagcctct ggattcacct tcagtagtaa tggcatgcac tgggtccgcc aggttccagg
      181 gaaggggctg gagtgggtgg cagttatatc gtatgatgta agtaagaaat actacgcaga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatgc tatatcttca
      301 aatgaacaac ctgaaattgg aggacacggc cgtgttctac tgtgtgagag actcttatgg
      361 gagtggtttg gatgcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000228             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:7161:7910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000228
VERSION     KCXD01000228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:7161:7910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58710.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       443..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          116 c          151 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaaattt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcggcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttttggcatc
      241 cactgggtcc gccaggctcc agggaagggc ctggagtggg tggcagttat atcgtctgat
      301 gaaagtaaga aatactacgc agactctgtg aaggaccgat tcaccatttc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaagt tggaggacac ggccgtctat
      421 tattgtgcga gagacgcata tggcagcggc tgcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000229             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21330:6867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000229
VERSION     KCXD01000229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21330:6867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58711.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       407..414
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..467
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          148 c          125 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtacaag aacatgcagt ttctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gagcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagt cgtaactggt ggagttgggt ccgccagccc ccaggcaagg gactggagtg
      241 gattggacgt atctctggta gtcttggaag caccagttac aatccctccc tcgagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt atttctgtgc gagacattca gaccccgcaa ctactagctg
      421 gtacttcgat ctctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000230             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:25260:9800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000230
VERSION     KCXD01000230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:25260:9800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..489
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58712.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       431..441
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>496
                     /gene="IGHG"
BASE COUNT          114 a          139 c          141 g          102 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcctggtg gcggcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact ggctgcgaca
      241 ggcccctgga aaagggcttg agtggttggg atgtgttgat tataaatatg atgaagaaat
      301 atacgcagac aatttccagg gcagagtcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcggcggg
      421 ccttggggga tatttactgc ttactgaata tttccagttc tggggccagg gcgccctggt
      481 caccgtctct tccgcc
//
LOCUS       KCXD01000231             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13095:12331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000231
VERSION     KCXD01000231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13095:12331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58713.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          137 c          142 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgatttgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgacg
      301 ttccagggga gagtcaccat gaccgaggac acgtctacag acacggccta catggagctg
      361 agtagcctga gatctgagga cacgggcgtg tattactgtg cgattggccc tagcggcagg
      421 tggaaccact ggtccttcga gatctgggga cctgggaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01000232             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5953:15812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000232
VERSION     KCXD01000232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5953:15812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58714.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       433..438
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          148 c          138 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgcccg
      121 ctctgaggtc cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattc tccacgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgcatatg gtgaaatgac
      301 acacgcagaa aacttccagg gcagactcac catgaccgag gacacgtcta cagacacggc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattatt gtgcgagatc
      421 atccagcggt acgtggctat actggtactt cgatacctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000233             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16834:7181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000233
VERSION     KCXD01000233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16834:7181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58715.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          142 c          135 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggatgg gactggagtg
      241 gattggcttt ttcggtggtt atggtgggaa cacctactac aacccctccc tccagagtcg
      301 agtcaccatt tcaaccgaca cgtccaagac ccagttctcc ctgatactgg cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000234             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10524:17687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000234
VERSION     KCXD01000234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10524:17687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58716.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          131 c          138 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag ggctggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctggagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatccatgg gagtgatagt agtaccaagt acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aatcaatgct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agtattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000235             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19328:4227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000235
VERSION     KCXD01000235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19328:4227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58717.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          140 c          133 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcggtctaa gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000236             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22225:20602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000236
VERSION     KCXD01000236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22225:20602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58718.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       431..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          137 c          148 g           99 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg cttctggata caccttcagc atctatgtca tcaattgggt gcgccaggcc
      241 cctggacaag ggctagagtg gatgggagga atcatccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt attacggaca cgtccacaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcccc
      421 cctactgaag ggggtgatta ttctgggggg gctttgagcc gatggggcca gggagtccag
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000237             395 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24402:18067
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000237
VERSION     KCXD01000237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 395)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 395)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24402:18067"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    30..393
                     /note="immunoglobulin heavy chain variable region"
     V_region        30..393
     V_segment       30..323
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <315..>362
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58719.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       337..342
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       349..393
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        394..>395
                     /gene="IGHG"
BASE COUNT           80 a          100 c          124 g           91 t
ORIGIN      
        1 atggggctct tttgaaaggt gtccagtgtg aggtgcagtt aatggagtct gggggcggct
       61 tggcaaagcc tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt
      121 actactacat gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggtc
      181 ttaacgctgg tggggatacc acctactatg cagactccgt gaagggcaga tccaccatct
      241 ccagagagaa cgccaagaac acactgcatc ttcaaatgga cagcctgaga gctgaggaca
      301 cggctgtcta ttactgtgtg agagatcgac gtgttcagtc gttatcctgg ttcgatgtct
      361 ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000238             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18492:8840
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000238
VERSION     KCXD01000238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18492:8840"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58720.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       433..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          145 c          142 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tccccaacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggac ttgttgatcc tgtaaatggt gaactaatac
      301 acgcagacaa gttccagggc agagtcacca tgaccgaaga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg acatctgagg acacggccat ctactactgt gcgacaggga
      421 ggatcggtac cagtggctgg tccaacctct tcaatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01000239             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21586:19121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000239
VERSION     KCXD01000239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21586:19121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..420
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58721.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       427..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          127 a          147 c          130 g           91 t
ORIGIN      
        1 acatgggggc agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcaacagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaagtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacaga ttcaccgaat cctccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgaatggatg ggaagtgttg atcctgaata tggtgaaatg
      301 ataaacacag agaatttcca ggacagagtc accctgaccg aggacacgtc tacagacaca
      361 gcctacatgg atctgagcac cctgcgatct gacgacacgg ccatatatta ctgtgcgaga
      421 gcccacagcg gcagctggaa taactggtac ttcgatctct ggggccctgg caccccaatc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000240             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17008:4925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000240
VERSION     KCXD01000240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17008:4925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58722.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       407..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           93 a          131 c          139 g          104 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg gctggtgaag cctccggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctctatcag cagtagttac tggagctgga tccgccagac cccagggaag ggactggagt
      241 ggattgggta tatccatggg agtgatagta gtaccaagta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga atcaatgctc cctgaagctg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagttcggg tatagaagtg gttgcctaca
      421 gtattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000241             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4988:4630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000241
VERSION     KCXD01000241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4988:4630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58723.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       414..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          118 a          140 c          134 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagga gcctggggcc tcagcgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagttgag cagcctaaga tctgaggaca cggccctgta ttattgtgca gtcgggtata
      421 gcggccgatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01000242             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16555:17275
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000242
VERSION     KCXD01000242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16555:17275"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58724.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          140 c          145 g          107 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata cagcttcagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggagac atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggca atggttgtaa ccttactttc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01000243             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23912:9721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000243
VERSION     KCXD01000243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23912:9721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..466
     V_segment       115..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58725.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       413..418
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT          106 a          133 c          138 g           91 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggcttctg gatacagctt caacatcgat gccatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agggatcatc cctcttgtcg gtataacaaa ctacgcacag
      301 aagttccagg gcagagtctc gattaccgcg gacacgtcca caagcacagc ctacatggaa
      361 ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgatcca agggaacagc
      421 cagtttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000244             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8161:10277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000244
VERSION     KCXD01000244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8161:10277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58726.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          136 c          136 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcttc tacaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcttgcactg tctctggtgg
      181 ctccttcagt ggttactact ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa tcaattctcc ctgaggctga cgtctatgac
      361 cgccgcggac acggccgtct atttctgtgc gagagatgcg ggagtgggag ccacaatcct
      421 gtactactat gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000245             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:6428:14363
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000245
VERSION     KCXD01000245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:6428:14363"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..279
     V_segment       8..217
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <211..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58727.1"
                     /translation="CATADYGNSLDFW"
     D_segment       223..234
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       239..279
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>282
                     /gene="IGHG"
BASE COUNT           68 a           69 c           75 g           70 t
ORIGIN      
        1 acatgggcct tcagtcgttt tggcatgcac tgggtccgcc aggctccagg gaaggggctg
       61 gagtgggtgg cagttatatc atctgatgga agtatgagtt tctactcaga ctctatgaag
      121 gaccgattta ccatctccag agacaattcc aagaacatag tatatcttca agtgaacaac
      181 ctgaagttgg aggacactgc cgtttattac tgtgcgacag ccgactacgg taacagcctt
      241 gacttctggg gccagggagt cctggtcacc gtctcctcaa cc
//
LOCUS       KCXD01000246             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24096:11797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000246
VERSION     KCXD01000246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24096:11797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58728.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       415..425
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          127 c          139 g          110 t
ORIGIN      
        1 acatggggac aaaacaacca catccctcct ctaaagaagc ccctgggagc acagctcatc
       61 accatggact ggacctggag gctcctcttt gtggtggcag cagctacagg tgtccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaaggtt
      181 tcctgcaagg cttctggatt taccttcgac aaatatggaa tcaactgggt gcggcaggcc
      241 cctggacaag ggcttgagtg gatgggagtg gtcatccccc ttgttggtat tatcaattat
      301 gcagagaact tccagggcag aataatgatt aacgcggaca cgtccataaa cacagccttc
      361 atggagttca ggagcctgag atctgacgac acggccattt atttctgtgc gagagaatac
      421 tgtacaacta ctgattgcgc cgggttcttt gactactggg gccagggagt cacggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01000247             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17151:5667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000247
VERSION     KCXD01000247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17151:5667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58729.1"
                     /translation="CARVRGGIAGYFDYW"
     D_segment       442..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          114 c          157 g          124 t
ORIGIN      
        1 acatggggct aggagaggag cccagccctg ggattcccag gtgttttcat ttgtgatcag
       61 cactgaacac agaagactca tcatggagtt tggcctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagggtg acgtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agcttcagtt acttctggat
      241 gtactgggtt cgccaggcac caggaaaggg gctggagtgg atctcagtta ttgatagtgg
      301 tggtgataac acatactatg cagactccat ggagggccga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgaa cagcctgagt gctgaggaca cggctgtcta
      421 tttctgtgcg agagtcaggg ggggtatagc agggtacttt gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000248             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:4892:16609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000248
VERSION     KCXD01000248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:4892:16609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58730.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          112 a          140 c          130 g           96 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ttggtacagt ctggggttga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggagaa ggacttgagt ggatgggagg tgttcatcct gaatttggta aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000249             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10399:8156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000249
VERSION     KCXD01000249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10399:8156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58731.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          120 c          149 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000250             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24360:17766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000250
VERSION     KCXD01000250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24360:17766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58732.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          114 c          150 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac aactagtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000251             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:19462:5662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000251
VERSION     KCXD01000251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:19462:5662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..491
     V_segment       128..421
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58733.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       431..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          118 c          149 g          118 t
ORIGIN      
        1 acatgggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag cacaaaacac
       61 agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt tgaaaggtgt
      121 ccagtgtgag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg gggggtccct
      181 gagactctcc tgcgcagcct ctggattcag cttcaattat tactacatga gctgggtccg
      241 ccaggctcca gggaaggggc tggagtggat ctcaggtatt aatagtggtg gggaaagcac
      301 atactctgca gactccgtga agggcagatt caccatctcc agagagaacg ccaagaacac
      361 gctatatctt gaaatggaca gcctgagaac tgaggacacg gctgtctatt attgtgtgag
      421 agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag ccctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000252             287 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24858:15989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000252
VERSION     KCXD01000252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24858:15989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    2..282
                     /note="immunoglobulin heavy chain variable region"
     V_region        2..282
     V_segment       2..212
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <204..>254
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58734.1"
                     /translation="CVRYEGAAAGTWYFDYW"
     D_segment       222..235
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..282
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        283..>287
                     /gene="IGHG"
BASE COUNT           64 a           79 c           83 g           61 t
ORIGIN      
        1 acatgggcag tagcttctgg agctggatcc gccagccccc agggaagggg ctggagtgga
       61 ttggatatat ctatggtgct actgggacca ccagctacaa tccccccctc aagagtcgag
      121 tcaccatttc aacagacacg tccaagaacc agttttccct gaaggtgaac tctgtgaccg
      181 ccgcggacac cgccgtatat tattgtgtga gatatgaggg ggcggcagct ggaacctggt
      241 actttgacta ctggggccag ggagtccagg tcaccgtctc cttagcc
//
LOCUS       KCXD01000253             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12578:15312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000253
VERSION     KCXD01000253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12578:15312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58735.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          102 a          125 c          155 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact acttcatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta ccagtggtgg
      301 ggctaacaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaccaca ctgtatcttc acatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtaaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000254             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17986:6619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000254
VERSION     KCXD01000254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17986:6619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58736.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          116 c          148 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aattggtgga gtctggagga ggtttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtttctgg attcaccttc agtaactatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattctaa caacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgaggcgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000255             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:26967:16181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000255
VERSION     KCXD01000255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:26967:16181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..504
     V_segment       123..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58737.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       425..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          140 c          145 g          105 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gttggtgcag tccggggctg aggtgaagag gcctggggcc tcagtgaagc
      181 tctcctgcaa ggctcctgga tacatcttca gtatatctgc catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag ggatcatccc tcttgttggt gtaacaacca
      301 acgcacagaa gttccaggac agagtcacga ttaccgcgga cacgtccaca agcacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtatttctgt gcgagtggcg
      421 gcttcgagga tgataacggt cactattata cgacactaac atttcacgat tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000256             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14073:3113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000256
VERSION     KCXD01000256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14073:3113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..500
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58738.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       440..447
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>506
                     /gene="IGHG"
BASE COUNT          121 a          142 c          144 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttcgt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg taaagtttcc ggatacacgg tcatcgattt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgaacat ggtgaagtaa
      301 tatacgcaga caacttccag ggcagagtcg ccatgagcga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgacatctg aggacacggc cgtgtattac tgtgcgaccc
      421 acggaggata tagaggcatc tggaactccc tatactacgg tttcgattcc tggggccaag
      481 gggtcgtcgt caccgtctcc ccagcc
//
LOCUS       KCXD01000257             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23776:6458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000257
VERSION     KCXD01000257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23776:6458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58739.1"
                     /translation="CARYEAEYSDYYFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          136 c          132 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacatgcgg tgtctctggt
      181 ggctccatca ccaatagtta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg tggtactggg agcaccggcc tcaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaac aaccagtttt ccctgaagct gatctctgtg
      361 accgccgcgg acaccgccgt gtattattgt gcgaggtatg aggctgaata cagtgactac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000258             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17034:4479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000258
VERSION     KCXD01000258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17034:4479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..437
     V_segment       83..376
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58740.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       386..391
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT          102 a           97 c          134 g          106 t
ORIGIN      
        1 acatggggaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
       61 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      121 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      181 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      241 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      301 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      361 atattactgt gcgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      421 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000259             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9721:7828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000259
VERSION     KCXD01000259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9721:7828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58741.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          115 c          150 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaagtttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acgcaagctc tgtgaagagc cgattcacca tctccagaga
      361 caattccaag aacatactat atctgcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000260             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21966:8617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000260
VERSION     KCXD01000260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21966:8617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58742.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          122 c          158 g          118 t
ORIGIN      
        1 acatggggac ctctgggaga ggagcccagc cccagagttc ccaggcgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgtggc
      121 tcttttgaaa ggagtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gccggggggg tccctgagac tctcctgcgt agtctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccggcagg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tggtgggact accacaaatt atgcagactc cgtgaggggc agcttcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg aaagccgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat tattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000261             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24255:19093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000261
VERSION     KCXD01000261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24255:19093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58743.1"
                     /translation="CAREYCTSDSCAGFLDYW"
     D_segment       423..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          138 c          140 g          105 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc
      121 agtcccaggt ccacttggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg caaggcttcg ggattcaccc tcgacaacta tggagtcaac tgggtacgtc
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat cccccttgtc ggtattgtga
      301 actacgtaga cagcctccag ggcagagcca cgataaccgc ggacacgtca acaaatacag
      361 tctacatgga actgaacagc ctgagatctg gcgacacggc catctattac tgtgcgagag
      421 agtactgtac ttctgattct tgcgccggat tcttagacta ctggggccag ggagtcctgg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01000262             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4817:7986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000262
VERSION     KCXD01000262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4817:7986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..466
     V_segment       91..384
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <376..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58744.1"
                     /translation="CARERFGGTGVIIYSWVDFW"
     D_segment       400..413
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           98 a          113 c          147 g          110 t
ORIGIN      
        1 acatggggat cagcactaaa cacagaacat accatggagt ttgtgctgag ctgggttttc
       61 cttcttgctc ttttgaaagg tgtccagtgt gaggtgcagt tggtggagtc tgggggcggc
      121 ttggcaaagc cgggggggtc cctgagactc tcctgcgcaa cctccggatt caccttcagt
      181 gacttctaca tggactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcacgt
      241 attaatcatg atggtggtag cacatggtac gcagactccg tgaggggcag attcaccatc
      301 tccagagaca acgccaagaa cacactgtat cttcaaatag acagcctgag acctgaggac
      361 acagccgtgt atttctgtgc gagagagcgg tttgggggaa ctggggtgat tatctacagc
      421 tgggtcgatt tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000263             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16898:10902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000263
VERSION     KCXD01000263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16898:10902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..494
     V_segment       146..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58745.1"
                     /translation="CARADRGSSIDFW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          149 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagttgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtggggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg taacctctgg attcaccttc agaacctatg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga gtgggtggcg gttatatcat
      301 atgatgatga caagaaattt tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tattttattg tgcgagagcg gatcgcggca gttcaattga cttctggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01000264             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:16083:12331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000264
VERSION     KCXD01000264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:16083:12331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..487
     V_segment       118..409
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58746.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       428..437
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          100 a          148 c          141 g          100 t
ORIGIN      
        1 acatggggga gctcacatgg gaaatgctct ctgagagtca cggacatcct gtgcaagaac
       61 atgaagcacc tgtggctctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag
      121 gtgcagctgc aggagtcggg cccaggactg gtgaagtcct cagagaccct gtccctcacc
      181 tgcgctgtct ctggtgcctc catcggtagt tactggtgga cctggatccg ccagccccca
      241 gggaagggac tggagtggat tggggagatc aatggaaata gcggtagtac ctactacagc
      301 ccctccctca agagtcgagt caccatttca aaagacgcgt ccaagaacca ccactccctg
      361 aagctgaacc ctgtgaccac cgcggacacg gccgtgtatt tctgtgcgaa cgtcttaggc
      421 ccctggggca gctggtcaca ctactttgag tactggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01000265             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16063:20007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000265
VERSION     KCXD01000265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16063:20007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..394
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58747.1"
                     /translation="CAKKYSGSYFYGHYDYW"
     D_segment       400..415
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          100 a          133 c          132 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatca gtgattactg gtggaactgg atccgccagc caccagggaa gggactggag
      241 tggattgcgg agatcaatgt tgatagtggt accacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccagttct ccctgaaggt gacttctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgaaaaagt atagtggcag ttatttctac
      421 ggacactatg actactgggg ccagggagtc ttggtcaccg tctcctcagc c
//
LOCUS       KCXD01000266             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8501:3861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000266
VERSION     KCXD01000266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8501:3861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..392
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58748.1"
                     /translation="CAKKYSGSYFYGHYDYW"
     D_segment       398..413
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           99 a          133 c          132 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagt gattactggt ggaactggat ccgccagcca ccagggaagg gactggagtg
      241 gattgcggag atcaatgttg atagtggtac cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgaaggtga cttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gaaaaagtat agtggcagtt atttctacgg
      421 acactatgac tactggggcc agggagtctt ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000267             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10225:23134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000267
VERSION     KCXD01000267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10225:23134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58749.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       420..428
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          112 a          144 c          132 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggcc gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggttcccgg acacaccttc agcgaattat ccattcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga ggttttgctc ctatatatgg tgaaatccta
      301 cacacagaca agttccaggg cagagtcacc ttgaccgagg acacgtctac agacaccgcc
      361 tatatggagt tgagcagcct gagatctgag gacacggccg tatattactg tgtggcggct
      421 gatagtggtt acccttttta ctacttcgat atctggggcc ctggcacccc aatcatcatc
      481 tcctcagcc
//
LOCUS       KCXD01000268             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8791:6594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000268
VERSION     KCXD01000268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8791:6594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58750.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          140 c          140 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgtcagg cttctggata ttccctcact cactacttca tgcactgggt gagacaggcc
      241 cctggacagg gccttgggtg gataggactg atcacccctc acaatgatca taaagtctac
      301 gcacagaact tccagggcag agtcaccata actacggaca cgtccacgag cacagtgtcc
      361 atggagctga gcagcctgag atccgaagac acagccgtat actactgtgc gagagggggg
      421 gacatagaat attgtactgg tagtggttgt ggggagcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000269             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:13431:14945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000269
VERSION     KCXD01000269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:13431:14945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58751.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       423..431
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          112 a          142 c          135 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaact acaggcgccc
      121 actctgaggt ccttctggtg cagtctgagg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggccg tgtattactg cgcgattggc cctagtggca
      421 gatggaacga ctggtccttc gacatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01000270             310 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15553:10856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000270
VERSION     KCXD01000270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 310)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 310)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15553:10856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..308
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..308
     V_segment       9..223
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <215..>277
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58752.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       232..239
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       263..308
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        309..>310
                     /gene="IGHG"
BASE COUNT           70 a           75 c           98 g           67 t
ORIGIN      
        1 acatggggac accttcaccg aattatccat gcactgggtg cgacaggccc ctggaaaagg
       61 gcttgattgg atgggaggtg ttgaccctgg aaatggtgaa ataatacacg cagatagttt
      121 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggagctgag
      181 cggcctgaga tctgaggaca cggccgtgta ttactgtgcg agaggggggt tcggtagcag
      241 tgtctggtcc aatctcgttt atggtttgga ttcctggggc caaggggtcg ccgtcaccgt
      301 ctcctcagcc
//
LOCUS       KCXD01000271             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19382:4268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000271
VERSION     KCXD01000271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19382:4268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58753.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           96 a          139 c          134 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctgctgaagc ctttggagac cctgtccctc acctgcgctg tttctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggaa caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagatctcc atgaaagtga cctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000272             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20780:5233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000272
VERSION     KCXD01000272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20780:5233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58754.1"
                     /translation="CATSPSGSWLFWYFDFW"
     D_segment       422..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          142 c          138 g           97 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gtagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag atttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaagg ttccagggca gagtcacctt gaccgaagac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcagc tggctatttt ggtacttcga tttctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000273             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10786:9777
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000273
VERSION     KCXD01000273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10786:9777"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58755.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          126 c          158 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tcggggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggtgat agcacatacc aggcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agaactgacg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000274             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13217:18341
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000274
VERSION     KCXD01000274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13217:18341"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..484
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58756.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       423..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          119 a          141 c          131 g           95 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccagctgg tgcagtctgg ggctgaggtg aagaaccctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacat cttaaccgaa ttatccatac actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggaagtgtt gatcctcaat atggtgaaat gatagacgca
      301 gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac agcctacttg
      361 gagctgagca gtctgagatc tgaggacacg gccgtgtatt actgtgcgac ctcatccagc
      421 ggcacctggc tatactggta cttcgatatc tggggccctg gcaccccaat caccatctcc
      481 tcagcc
//
LOCUS       KCXD01000275             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18908:15179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000275
VERSION     KCXD01000275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18908:15179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58757.1"
                     /translation="CVRGMDNYHYINTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          123 c          147 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgtct tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctac
      241 gacatgcact gggtccgcca ggctccaggg aagggtctgg agtgggtttc aggtattaac
      301 attggcgatg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacaacctga gagctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cactacatta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000276             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16175:9595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000276
VERSION     KCXD01000276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16175:9595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58758.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          123 c          152 g          126 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gaccaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtactactac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000277             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20968:15609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000277
VERSION     KCXD01000277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20968:15609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58759.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       431..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          124 c          150 g          105 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcggcc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacagtg tcaccgaatt atcgattcac tgggtgcgac
      241 aggccccggg aaaagggctt gagtggatgg gaggtgttga tcctgtaaaa ggtgaagaaa
      301 ttcacggaga ggagttccag gacagagtca ccatgaccga ggacccgtct acagacacag
      361 cctacatgga gttgagcaac ctgagatctg aggacacggc cgtgtattat tgtgcgagtg
      421 ggtttagtat ctggttattt tacgacgttt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000278             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13861:4224
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000278
VERSION     KCXD01000278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13861:4224"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58760.1"
                     /translation="CAGGAYANLDYW"
     D_segment       435..439
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          124 c          153 g          111 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca aatggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagatactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctcttaatta
      301 tgatggggat agtacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcaaag aacacgctct ccctacaaat gcacagcctg agagaggatg acacggccgt
      421 atatttctgt gcgggtgggg cgtacgctaa cctcgactat tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000279             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15885:18166
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000279
VERSION     KCXD01000279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15885:18166"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58761.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       423..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          109 a          145 c          141 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgacttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctctatatgg tgaaatgatg
      301 ctcgcagaca acttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaccagcct gagatctgac gacacggccg tgtattactg tgcgcgtggg
      421 cctattacaa tttttggcgt acttattacg gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000280             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15183:17219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000280
VERSION     KCXD01000280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15183:17219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58762.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          138 c          145 g           97 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacctactcc aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaagaa ccagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgg cgggggtcga
      421 ctactggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000281             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17355:14914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000281
VERSION     KCXD01000281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17355:14914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    19..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        19..373
     V_segment       19..312
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <304..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58763.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       316..331
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       339..373
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           87 a          103 c          107 g           78 t
ORIGIN      
        1 acatggggag tctgtgccga ggtgaaactg gtgcagtctg gggcagaggt gagaaggccc
       61 ggggagtctc tgaagatctc ctgtaagact tctggataca gctttaccac caactggatc
      121 agttgggtgc gccagacgcc cggaaaaggc ctggaatgga tggggaccat ctatcctgct
      181 gattctgagg ccaaatacaa cccgtccttc caaggccacg tcactatctc agccgacaag
      241 tccatcagta ccacctacct gcagtggagc agcctgaagg cctcggacac cgccacgtat
      301 ttctgtgcga aaacctacta tagtggtagt ttggaaatct ggggccaggg agtcctggtc
      361 accgtctcct cagcc
//
LOCUS       KCXD01000282             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:2991:14344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000282
VERSION     KCXD01000282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:2991:14344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58764.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcattcactg ggtccgccag actccaggga aggggctgga gtgggtggcc gttatatcgt
      301 atgatgaaac taagacatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaccatggtg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tattttactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000283             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:7608:19237
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000283
VERSION     KCXD01000283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:7608:19237"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58765.1"
                     /translation="CARGTTHLETAAGIGDYFDSW"
     D_segment       427..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          145 c          145 g           93 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcggctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttccgg atacaccttc agcatccatg gcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tttaacacac tacgcacaga
      301 agttccaggg cagagtcaca attaccgcgg acacgcccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tatattactg tgcgagaggg acaacccacc
      421 tcgagacggc agctggaatc ggagactact ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000284             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6843:16960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000284
VERSION     KCXD01000284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6843:16960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58766.1"
                     /translation="CARDVYGGGLDYW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          117 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga gtctggagga ggcttggttc
      181 agcctggtgg gtccctgaga ctctcctgtt cagcctcagg attcaccttc aacacctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctttgagaga ccgattcacc atatccagag
      361 acagctccaa gaacatggta tatcttctac tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagat gtttatggtg gggggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000285             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20854:6769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000285
VERSION     KCXD01000285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20854:6769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58767.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           98 a          137 c          125 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggcc ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc aactcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagtt acaacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccaatttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccat gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000286             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:23396:7514
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000286
VERSION     KCXD01000286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:23396:7514"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58768.1"
                     /translation="CARVDSSGWYLPALDVW"
     D_segment       402..418
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           84 a          141 c          141 g          106 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctacagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtttctgg
      181 tggctccatc agcagttact actggacctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtctctttg gtagtagtgg gagcaccagt tacaacccct ccctctcgag
      301 tcgagtcacc ttttcaacag acacgtccaa gaaccagttc tccctgacgc tgggctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagtg gatagcagcg gctggtactt
      421 gccggcattg gatgtctggg gccggggagt tctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000287             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11995:19202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000287
VERSION     KCXD01000287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11995:19202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58769.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          116 c          146 g          131 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcgt tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggaatctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagttc ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tttccggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtacaaggg ggatagataa ctaccacttt agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000288             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7684:9630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000288
VERSION     KCXD01000288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7684:9630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58770.1"
                     /translation="CVRDGYGSGLDSW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          106 c          157 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ggggggagtc cctgagactc tcctgtgtag cttctggatt caccttcagc acgtttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt ataacgaatg
      301 atggaagtaa gaattactac gcagactctg tgaaggaccg attcaccgtc tccagagaca
      361 attccaagaa tatgctatac attcaaatga acaacctgaa attggaggac acggccgttt
      421 attactgtgt gagagatggg tacggtagtg gtttggattc ttggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000289             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:9672:7912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000289
VERSION     KCXD01000289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:9672:7912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58771.1"
                     /translation="CARVTGHTEGTVEYFDYW"
     D_segment       442..458
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          117 c          156 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcacttata tcgtttgatg
      301 gaactaagca atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gttatatctt cagatgaaca acctgaaatt gggggacacg gccgtgcatt
      421 tctgtgcgag agttactggg catacagagg gtacagttga atactttgac tactggggcc
      481 agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000290             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:9338:20357
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000290
VERSION     KCXD01000290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:9338:20357"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58772.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          102 a          123 c          156 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcatc cggattcagc ttcagtgacc actgcatgca
      241 ctgggtccgc caggcttcag ggaaggggct ggggtgggtc tcaggtatta cttatactgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgtggga ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000291             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20537:14741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000291
VERSION     KCXD01000291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20537:14741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58773.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          112 c          144 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctcttt
      121 taagaggtgt ccagtgtgag gtgcaattgg tggagtctgg aggaggcttg attcagcctg
      181 gggggtccct gaggctctcc tgtgcagcct ctggattcac cttcagtaat tatggcttcc
      241 actgggtccg ccaggctcca gtgaaggggc tggagtgggt tgcagttatg tcgtatgatg
      301 aaaatgtgaa atactacgca gactctgtaa aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000292             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:25871:8601
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000292
VERSION     KCXD01000292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:25871:8601"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58774.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          119 c          150 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 gccctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag actccaggga aggggctgga gtgggtggca gttttgtcgt
      301 ctgatggagg ttacaaatac cacgcagact ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000293             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:25676:14719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000293
VERSION     KCXD01000293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:25676:14719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58775.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       441..449
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          113 c          148 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgcgatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccgga
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtttct atggcttcca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt cgaatgatga
      301 aaataacaaa tactacgcag actctgtgaa ggaccgattc accatttcta gagacaattc
      361 catgaacatg ctatttcttc aaatgaacaa cctgaacttg gacgacacgg ccgtctatta
      421 ttgtgtgaga gatgatttag gcagcggctt agggtcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000294             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15842:19723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000294
VERSION     KCXD01000294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15842:19723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58776.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       417..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          145 c          137 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagcaaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc cattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gcgttgatcc tgcatatggt gaatttacac
      301 ccggagagaa gttccagggc agagtcacca tgaccgagga ctcgtctgta gacacagcct
      361 acatggagct gagcagcctg aattctgagg acacggccgt ctattactgt gcagccgggt
      421 atagcggcag ctggaaccac tggtacttcg atctctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000295             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12404:8378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000295
VERSION     KCXD01000295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12404:8378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58777.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          144 c          132 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggtgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgac cctgcatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatctga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000296             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6203:19346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000296
VERSION     KCXD01000296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6203:19346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..359
     V_segment       8..272
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <266..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58778.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       291..301
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       314..359
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           86 a           93 c          107 g           75 t
ORIGIN      
        1 acatggggag gtgaagaagc ctggggcctc agtgaaggtc tcctgcaagg tttccggata
       61 caccgtcacc gaattatcca tgcactgggt gcgacaggcc cctggacaag ggcttgagtg
      121 gatgggactt gttgatcctg taaatggtga actaatacac gcagacaagt tccagggcag
      181 agtcaccatg accgaagaca cgtctacaga cacagcctac atggagttga gcagcctgac
      241 atctgaggac acggccatct actactgtgc gacagggagg atcggtacca gtggctggtc
      301 caacctcttc aatggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcttcagc
      361 c
//
LOCUS       KCXD01000297             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:25325:11779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000297
VERSION     KCXD01000297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:25325:11779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58779.1"
                     /translation="CARDGRGSGTDVW"
     D_segment       442..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          110 c          159 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccgtcagt agttttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atggaaatac gagattctac gcagactctg tgaaggaccg attcaccatc tccagcgaca
      361 attccaagaa catggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgtgc gagagatggg cggggttcag gcacggatgt ctggggtcgg ggagttctag
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000298             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21527:5162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000298
VERSION     KCXD01000298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21527:5162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58780.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       261..267
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           76 a           79 c           87 g           78 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
       61 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      121 ctgatggaag tcacaaatac tacgccaact ctgtgaagag ccgattcgcc atctccagag
      181 acaattccaa gaacatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      241 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000299             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13863:14553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000299
VERSION     KCXD01000299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13863:14553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58781.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       438..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          117 c          149 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtacagcc tctggattca ccttcagtac ctctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggc tgacagttat atcgtatgat
      301 gaaactaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgaaat tggaggacgc ggccgtgtat
      421 tactgtgcga gagattctta cggtcgaggc tttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000300             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18755:11829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000300
VERSION     KCXD01000300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18755:11829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..250
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <244..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58782.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       264..274
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..325
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           76 a           91 c           92 g           68 t
ORIGIN      
        1 acatgggagc ctggggcctc agtgagggtc tcctgcaaga tttccggata caccttcacc
       61 gaattatcca tacactgggt gcggcaggcc cctggaaaag ggcttgagtg gatgggaagt
      121 gttgatcctc tatatggtga aatgaagttc cagggcagag tcaccatgac cgaggacacg
      181 tctacagaca cagcctacat ggaactgagt agcctgacat ctgaggacac ggccgtgtat
      241 tactgtgcga ctggccctag cggcacctgg aacgcctggt acctcgatat ctggggccct
      301 ggcacctcaa tcaccatctc ctcagcc
//
LOCUS       KCXD01000301             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12795:15740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000301
VERSION     KCXD01000301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12795:15740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58783.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          121 a          142 c          141 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctgggacc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt atatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggt
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000302             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13411:11518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000302
VERSION     KCXD01000302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13411:11518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58784.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       268..274
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           80 a           74 c           94 g           74 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagtta
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtga cagttatatc
      121 gtatgatgta agtaagaaat actacgcaga cgctgtgaag gaccgattca ccatctccag
      181 agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtgtattac tgtgggagag atgataatgg ggtgcttatc gactactggg gccagggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000303             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16338:16047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000303
VERSION     KCXD01000303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16338:16047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58785.1"
                     /translation="CARGWFGSSVWSNLVYGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          139 c          153 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggtgttgatc ctgcaaatgg tgaggtaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 tggttcggta gcagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000304             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10145:5814
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000304
VERSION     KCXD01000304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10145:5814"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58786.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          117 a          140 c          148 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacaacac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg agacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg ggaaataata
      301 cacgcagata acttccaggg cagagtcacc atgaccgagg acacgtctat agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tatattactg tgcgagcggg
      421 acatttggga ccagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca gcgtctcctc agcc
//
LOCUS       KCXD01000305             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:27012:12367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000305
VERSION     KCXD01000305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:27012:12367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58787.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       269..274
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           74 a           79 c           97 g           73 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gtgcagtctc tgggttcacc ttcagtggct
       61 ctggcatgca ctgggtccgc caggctccag ggaaggggct ggaatgggtg gcggttatat
      121 cgaatgatgg aactaacaaa tactacgcag actctctgaa ggaccgattt agtatctcca
      181 gagagaattc caagaacatg ctatatcttc aaatgaacaa cctgaaactg gaggacacgg
      241 ccgtctatta ctgcgcgaca gatgcgtttg gtagcgggat tgactactgg ggccggggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000306             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12126:24109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000306
VERSION     KCXD01000306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12126:24109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..341
     V_segment       4..254
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58788.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       269..281
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..341
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           76 a           87 c          107 g           73 t
ORIGIN      
        1 acatggggcc tcagtaaagg tctcctgcca ggtttccgga tacaccttca gtgaaatgtc
       61 catgcactgg gtgcgacagg cccctggaaa agggcttgag tggatgggat gtgttgctcc
      121 tggaaatggt gaaataatac acgcagagag cttccagggc agagtcacca tgaccgagga
      181 cacgtctaca gacacagcct acatggagct gagtagcctg agatctgagg acacggccgt
      241 gtattactgt gcgacaggga ggttcgggag cagcgtctgg tccagcctct tctacggttt
      301 ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000307             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:25974:6980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000307
VERSION     KCXD01000307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:25974:6980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58789.1"
                     /translation="CARYDEDDYANYYLDYW"
     D_segment       401..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          141 c          129 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtagttt ctggttctgg atccgccagc ccccagggaa gggactggag
      241 tggattggct atatctctgg tgctactggg agcaccagct acagcccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcccag aaccagtttt ccctgaaact gacctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgaggatga ttacgctaac
      421 tattaccttg actactgggg tcagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000308             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13800:13230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000308
VERSION     KCXD01000308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13800:13230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58790.1"
                     /translation="CAREYCTSSTCAGFLDSW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          107 a          138 c          135 g          105 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag tcccaggtcc
      121 gcctggtgca gtccgggact gaggtgaaga agcctggggc ctcagtgaag atttcctgcg
      181 gggcttctgg tttcaccctc gacacctatg gtatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttattgg tatcatcaac tacgcagaga
      301 actctcaggg cagactcaca ataaccgcga acacgtccac aaatacagcc tatatggaac
      361 tgagcagtct gagatctgag gacacggcca tctattactg tgcgagagaa tactgtactt
      421 ctagtacttg cgccgggttc cttgactcct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01000309             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15557:13900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000309
VERSION     KCXD01000309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15557:13900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58791.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          117 c          149 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtgtatctt caaatgaaca acctgacatt tgaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgattcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000310             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10662:12727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000310
VERSION     KCXD01000310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10662:12727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58792.1"
                     /translation="CGRDDSGVLIDYW"
     D_segment       445..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          114 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 ccagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 gtattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttt agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggcg gttacatcgt
      301 ctgatgaaag taacaaatac tacgcagact ctgcgaagga ccgattcacc atctccagag
      361 acaattccaa gaacctggta tatcttcaaa tgaacaatct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gattctgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000311             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:6016:8361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000311
VERSION     KCXD01000311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:6016:8361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58793.1"
                     /translation="CARGTVTLGTLDSW"
     D_segment       400..408
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           91 a          132 c          137 g          103 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga catcctgtgc aagaacatga agtacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcaactgca ctgtctctgg
      181 tggctccatc agaggttact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg ggtgtcggtg gtattactgg gatttcggac tacagcccct ccctcaaaag
      301 tcgagtcacc atttcaagag acacgtccaa gaaccagttg tccctgaatc tgaccgttgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaggt acagtaacct tgggaaccct
      421 tgactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000312             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9908:8242
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000312
VERSION     KCXD01000312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9908:8242"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58794.1"
                     /translation="CVRVHDYAMYYFDYW"
     D_segment       265..272
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           79 a           77 c           93 g           79 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tggagcctct ggattcacct tcagtagtta
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtga cagttatatc
      121 gcatgatgga agtaagaaat actacgcaga ctctgtgaag gaccgattca ccgtctctag
      181 agacaattcc aagaatatgg tatatcttca aatgaatacc ctgaaattgg aggacacggc
      241 cgtgtattac tgtgtgagag tccatgacta cgccatgtac tactttgact actggggcca
      301 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000313             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22588:12785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000313
VERSION     KCXD01000313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22588:12785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58795.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       437..443
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          115 c          147 g          122 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccggtgtg aggtgcaact ggtggagtct ggaggaggct tggttcaacc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta attttggcat
      241 acactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tttcgtctga
      301 tggaagtcac aaatactacg ccaactctgt gaagagccga ttcgccatct ccagagacaa
      361 ttccaagaac atactatatc ttcaaatgaa caacttgaaa ttggaggaca cggccgtcta
      421 ttactgtgcg agagatgata ttgggaccgg ttttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000314             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6607:16689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000314
VERSION     KCXD01000314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6607:16689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58796.1"
                     /translation="CARDRRVESLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          126 c          155 g          124 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag ttactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaccagt
      301 ggtgggggta acacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aactccaaga ccacactgta tcttcacatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg caagagatcg acgtgtagag tcgttatcct ggttcgatgt ttggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000315             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24762:8757
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000315
VERSION     KCXD01000315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24762:8757"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58797.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       405..411
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           82 a          138 c          140 g          104 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gttcccagat gggtcctgtc ccaggtgcgg ctgcaggagt
      121 cgggcccagg acttgtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccttcag cggttactac tggggctgga tccgccggcc cccaggggag ggtctggagt
      241 ggattgggta tatcagtggg agtggtggga gttccgacta caagtcctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagtccg gggcgtaact atccactact
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000316             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14485:16032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000316
VERSION     KCXD01000316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14485:16032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58798.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       439..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          121 c          147 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatcttca gtaactatgc
      241 catgcactgg gtccgccagg ctccagggaa ggggctagag tgggtggcag ttatttcgca
      301 tgatggaact aagaaatact acacagactc tgcgaaggac cgattcacca tctccagaga
      361 caattccaag aacatacaat atcttcacat gaacagcctg aaattggagg acacggccat
      421 atactactgt gcggcctcct acttggggta cggttttgag tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000317             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18879:2077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000317
VERSION     KCXD01000317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18879:2077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..344
     V_segment       8..270
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <263..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58799.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       283..291
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..344
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           81 a           75 c          109 g           81 t
ORIGIN      
        1 acatggggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggttt ccggatacag
       61 tgtcaccgaa ttatcgattc actgggtgcg acaggcccct ggaaaagggc ttgagtggat
      121 gggaggtgtt gatcctgtaa aaggtgaaga aattcacgga gaggacttcc aggacagagt
      181 caccatgacc gaggacccgt ctacagacac agcctacatg gagttgagca acctgagatc
      241 tgaggacacg ggcgtgtatt attgtgcgag tgggtttagt atctggttat tttacgacgt
      301 tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01000318             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14933:15840
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000318
VERSION     KCXD01000318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14933:15840"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58800.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          139 c          151 g           99 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgacc ctgcaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 gggttcggta gcagtgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000319             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21205:6917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000319
VERSION     KCXD01000319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21205:6917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58801.1"
                     /translation="CARDRLGGGWFDYW"
     D_segment       412..423
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          134 c          137 g          102 t
ORIGIN      
        1 acatggggga atgttctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctacagg
      121 agtcgggccc aggagtggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcgatagt tacaggtgga gctggatccg tcagccccca gggaaggaac
      241 tggagtggat agggtacatc tatggtggta atacgggcac caactacaac ccctccctca
      301 aaagtcgagt caccatttca aaagacacgt ccacgaacca gttctccttg aaactgagct
      361 ctgtgaccgc cgcggacacg gccgtgtatt cctgtgcgag agatcggctt ggcggtggct
      421 ggtttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000320             386 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18630:15805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000320
VERSION     KCXD01000320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 386)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 386)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18630:15805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    162..384
                     /note="immunoglobulin heavy chain variable region"
     V_region        162..384
     V_segment       162..323
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <315..>353
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58802.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       332..338
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       345..384
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        385..>386
                     /gene="IGHG"
BASE COUNT           97 a           83 c          113 g           93 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggtgca cctggtggag tctggagtgg gtggcagtta
      181 tatcgtatga tgtaagtaag aaatactacg cagacgctgt gaaggaccga ttcaccatct
      241 ccagagacaa ttccaagaac acactatatc ttcaaatgaa caacctgaaa ttggaggaca
      301 cggccgtgta ttactgtggg agagatgata atggggtgct tatcgactac tggggccagg
      361 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000321             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12648:16707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000321
VERSION     KCXD01000321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12648:16707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58803.1"
                     /translation="CTRGNIAATGIDYW"
     D_segment       399..406
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           86 a          132 c          138 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcgggg accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt atatcggtgg tagtaatggg aacatcttct ataacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaatct gatctctgtg
      361 tccgccgcgg acacggccgt gtattactgt acgaggggga atattgcagc gactggcatt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000322             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:11432:4741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000322
VERSION     KCXD01000322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:11432:4741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58804.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       433..439
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          117 c          145 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtccacc tggtggaatc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt agctttggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg atgaaagtaa
      301 gaaatactac gccgactctt tgaaagaccg attcaccata tccagagacg actccaggaa
      361 catgctatat cttcaactga acaacctgaa attggacgac acggccgtgt attactgtgc
      421 gagagatgtg tatggctggg ggcttgacta ctggggccag ggagtcctag tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000323             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:9465:6338
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000323
VERSION     KCXD01000323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:9465:6338"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58805.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           93 a          132 c          127 g          107 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 agcagtagct actggaactg gatccgccag cccccaggga agggactgga gtggattggg
      241 tatatctctg gtgcttatgg gagcaccagt tacaacccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggc tgatttctgt gaccgccgcg
      361 gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta tcactttgac
      421 ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000324             527 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5169:20432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000324
VERSION     KCXD01000324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5169:20432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..525
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..525
     V_segment       144..436
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>494
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58806.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       451..470
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       483..525
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        526..>527
                     /gene="IGHG"
BASE COUNT          113 a          131 c          155 g          128 t
ORIGIN      
        1 acatgggagc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag tgtgaggtgc aactggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttacg
      241 acatgacctg ggtccgccag gctccgggaa aggggctgga gtgggtctca tatattagtt
      301 acactggtaa aaccatatac tactctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgtcaa gaactctctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattattg ttctagagcg gcttacgaac atgatgacgg ttactattac gtcggcaggt
      481 tttttgactg ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000325             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:26595:11293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000325
VERSION     KCXD01000325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:26595:11293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58807.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       406..413
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           82 a          143 c          138 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttactc ctggagctgg atccgccagc ccccaggcaa gggtctggag
      241 tggattggac atgtcagtgg tagtagtggg agcaccgact acagcccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag cgccagttct ccctgaggct gatttctgtg
      361 accgccgcgg acacggccgt ctatcattgt gcgagagtcc ggggcgtgac tatctattac
      421 tttgactact ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01000326             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16692:15730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000326
VERSION     KCXD01000326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16692:15730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..485
     V_segment       120..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58808.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       419..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>488
                     /gene="IGHG"
BASE COUNT          114 a          143 c          137 g           94 t
ORIGIN      
        1 atggggatca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgacg tgaagaagcc tggggcctct gtgaaggtct
      181 cctgcaaggt ttccggatac accttcaccg agttatccat acactgggtg cgacaggccc
      241 ctggaaaagg gcttcagtgg atgggaagtg ttgatcctgc atatggtgaa atgataaaca
      301 cagagaagtt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgtcta tttctgtgcg agtggcccta
      421 gcggcagctg gaacggctgg tacttcgata tctggggccc tggcacccct atcaccgtct
      481 cctcaacc
//
LOCUS       KCXD01000327             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20548:19094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000327
VERSION     KCXD01000327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20548:19094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..498
     V_segment       146..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58809.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          118 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgtgtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgtggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaacctttg
      241 gcatgcatcg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 ctgatggagg ttacaaatac tacgcagact ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000328             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5654:12097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000328
VERSION     KCXD01000328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5654:12097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58810.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           98 a          143 c          135 g          110 t
ORIGIN      
        1 acagggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt tccagttact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tactaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagtcg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaagggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000329             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10579:7349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000329
VERSION     KCXD01000329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10579:7349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58811.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       441..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          104 a          124 c          157 g          113 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaaatcc caggggtttc tgttcggcga
       61 tcagcactaa acacagaaca caccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccattg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctaagact ctcctgtgca gcatccggat tcaccttcag tgaccactgc
      241 atgcactggg tccgccaggg ttcagggaag gggctggagt gggtctcagg tattacttat
      301 actggtgtta ccacatggta cgtagactcc gtgaggggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg tgggaggaag gcggcacgtg gaccttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000330             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17022:13882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000330
VERSION     KCXD01000330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17022:13882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58812.1"
                     /translation="CATGRIGSSGWSTLFTGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          147 c          144 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa ggccttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggaagc agcggctggt ccaccctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000331             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:23090:12142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000331
VERSION     KCXD01000331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:23090:12142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..465
     V_segment       96..389
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58813.1"
                     /translation="CARERCTASSCAGFLDSW"
     D_segment       395..400
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          104 a          128 c          142 g           93 t
ORIGIN      
        1 acatgggaac gcagagtaca tggggacagc tcatcaccat ggactggacc tggaggctcc
       61 tctttgtggt ggcagcagct acaggtgtcc agtcccaggt ccagctggta cagtccgggg
      121 ctgaggtgaa gaagcctggg gcctcagtga aagtttcctg caaggcttct ggattcaccc
      181 tcgacaacta tggcatcaac tgggtgcgcc aggcccctgg acaggggctt gagtggatgg
      241 gagtgatcat ccccctaatt ggaataataa actacgcaga gaacgtccag ggcagagccg
      301 cgatttccgc ggacacgtcc ataaatacag cctacatgga ggtgcgcagc ctgagatctg
      361 aggacacggc catctattac tgtgcgcgag aacgttgtac cgctagcagt tgcgccggat
      421 tcctagactc ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000332             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:11919:16621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000332
VERSION     KCXD01000332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:11919:16621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58814.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       442..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          116 c          161 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccagtcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcactgata tcgtatgatg
      301 gaggtaagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatgaaca acctgaactt ggcggacacg gccgtgtatt
      421 tttgtgcgag agttggagag ggtactggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000333             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15363:18138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000333
VERSION     KCXD01000333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15363:18138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58815.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          111 a          144 c          135 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aaggtttccg gatacacctt caccgattta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctgca gacacagcct acatggaact
      361 gagtagcctg acatctgagg acacggccgt gtattactgt gcgactggcc ctagcggcac
      421 ctggaacgcc tggtacctcg aaatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01000334             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18397:12670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000334
VERSION     KCXD01000334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18397:12670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58816.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       411..417
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          148 c          132 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtctccgg aaacaccttc accgaattgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ccgcatatgg tgaaatgacg
      301 ttccagggca gagtcatcat gaccgaggac acgtctacag acacagctta catggaactg
      361 accagcctga catctgacga cacggccgtc tattactgtg cggttggccc tagtggcact
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc cagtcaccat ctcctcagcc
//
LOCUS       KCXD01000335             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9692:7841
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000335
VERSION     KCXD01000335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9692:7841"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58817.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       412..419
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          105 a          138 c          147 g          104 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctataga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacacgttc agcatctatg ccatcagttg ggtgcgacag gcccctggcc
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tacaacaaat tacgcacaga
      301 agttccaggg cagagtcacc attaccgcgg acacgtccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagggga gattgtactg
      421 atactgactg ctcttccgcg gggggcgcct ttgatttctg gggccaagga ctcagggtca
      481 ccgtctcttc agcc
//
LOCUS       KCXD01000336             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12440:10232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000336
VERSION     KCXD01000336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12440:10232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..329
     V_segment       71..249
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58818.1"
                     /translation="CTTHYGGSYYLDYFDSW"
     D_segment       258..276
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           84 a           70 c           96 g           81 t
ORIGIN      
        1 acatgggggg ttttccttgt tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg
       61 gagtctgggg caggcttctg ggaaaggact ggagtgggtt ggatatatta gaagcataca
      121 taggaattac gcgacagaat acgccgcatc ggtgaaaggc agattcacca tctccagaga
      181 tgattcaaag aaaatgctat ggctgcaaat gagcagcctg gaaaccgagg acacggccgt
      241 ctattactgc accacccact atggtggtag ttattattta gactactttg actcctgggg
      301 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000337             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7674:12655
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000337
VERSION     KCXD01000337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7674:12655"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58819.1"
                     /translation="CVRRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          111 c          151 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttt agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattattg tgtgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01000338             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:10455:19595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000338
VERSION     KCXD01000338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:10455:19595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58820.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          118 a          119 c          143 g          130 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggtggagt ctgggggaga cttggtacag
      181 cctggggcgt ccctgagact ctcctgtgca gcctctgaat tcaccttcag tgcctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctagaat gggtatcagg aattaacatt
      301 ggcggtgacc catactaccc agactctgtt aagggtcgat tcaccatctc cagagacaat
      361 gccaagaact ccttgtatct tcagatgaac aatctgagag ctgaggacac tgctgtgtat
      421 tattgtgtga ggggaatgga taactaccac tacagtaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000339             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23178:14808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000339
VERSION     KCXD01000339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23178:14808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58821.1"
                     /translation="CARSGDYGYYYDFDYW"
     D_segment       404..422
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          138 c          133 g          103 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcctcct cctgctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcagtaac tcctggaact ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg acgtttctat aatagtggtg ggaacaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgaag ctgaactctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagatc gggtgattac ggttactatt
      421 acgactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000340             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7790:2479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000340
VERSION     KCXD01000340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7790:2479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58822.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       412..419
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           87 a          138 c          144 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gccccaggga agggactgga
      241 gtggattggt tttatctatg gtactagtgg tagcacctac tacacaccct ccctcaagag
      301 gcgactcacc atttcagcgg acacgtccaa gaaccagttc tccctgcatc tgacctctgt
      361 aaccgccgcg gacacggccg tgtattactg tgcgagagtt tcgggcaggt gggaactatt
      421 tgagcctggg tcagaggact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000341             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20915:12569
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000341
VERSION     KCXD01000341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20915:12569"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58823.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       402..413
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           96 a          137 c          138 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaga acctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cagtaactac tggagctgga tccgccagtc cccaggaaag ggactggagt
      241 ggattggacg tatttctggg agtggtggga gcaccgtcta caacccctcc ctcaagagtc
      301 gagtcacctt ttcaacagac acgtccaaga acgagatctc cctgaaagtg acctctgtga
      361 ccgccgcgga cacggccgta tattattgtg cgacagccgg atatagcagc agcgaaagct
      421 tctacggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000342             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22809:5179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000342
VERSION     KCXD01000342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22809:5179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58824.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       424..431
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          137 c          151 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctataga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgaccct gcaaatggtg aaataataca
      301 cgcagatagt ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagaggggg
      421 gttcggtagc agtgtctggt ccaatctcgt ctatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000343             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23563:5752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000343
VERSION     KCXD01000343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23563:5752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58825.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          115 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggagggg gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcatc
      301 tgatggaagt aacaaatact acgcaaactc tgtgaaggac cgatttacca tctccagaga
      361 caattccaag aacatagtat atcttcaaat gaacaacctg aaatcggagg acacggccgt
      421 ctattactgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000344             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23322:10702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000344
VERSION     KCXD01000344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23322:10702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58826.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          111 a          121 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactc ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagtc tgagagccga ggacacggcc
      421 gtgtattact gtactagaaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000345             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20479:20079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000345
VERSION     KCXD01000345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20479:20079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58827.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           92 a          139 c          130 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacgcac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc aacaatcaac tctccctgaa ggtgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000346             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19482:16526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000346
VERSION     KCXD01000346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19482:16526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58828.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          113 a          143 c          133 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaaatgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01000347             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6780:16491
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000347
VERSION     KCXD01000347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6780:16491"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..523
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58829.1"
                     /translation="CAKVDHEDDYGFYYTWSYFDSW"
     D_segment       443..470
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          112 a          129 c          160 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggggg cggcttggca
      181 aagcctgggg gatccctgag acttacctgt gcagcctctg gattcacctt cagtaggtat
      241 gccatgcact gggtccgcca ggctccagac aaggggctgg agtgggtctc agttattagt
      301 agtggtggta gcacatacta cgcagactcc gtgaagggcc gattcaccat ctccagagac
      361 aactcaaaga ccacgctctc cctgcaaatg aacagcctga gacctgggga cacggccgtg
      421 tattactgtg cgaaagttga tcacgaggat gattacggtt tctattacac ttggagttac
      481 tttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000348             396 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23563:3983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000348
VERSION     KCXD01000348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23563:3983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    28..394
                     /note="immunoglobulin heavy chain variable region"
     V_region        28..394
     V_segment       28..319
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <313..>363
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58830.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       333..339
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       343..394
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        395..>396
                     /gene="IGHG"
BASE COUNT           97 a          103 c          116 g           80 t
ORIGIN      
        1 acatgggcag ctacaggcgc ccactctgag gtccagctgg tgcagtctgg ggctgaggtg
       61 aagaagcctg gggcctcagt gaaggtctcc tgcaaggttt ccggatacat cttaaccgaa
      121 ttatccatac actgggtgcg acaggcccct ggaaaagggc ttgagtggat gggaagtgtt
      181 gatcctcaat atggtgaaat gatagacgca gagaaagtcc aaggcagagt caccatgacc
      241 gaggacacgt ctacagacac agcctacatg gagctgagca gtctgagatc tgaggacacg
      301 gccgtgtatt actgtgcgac atcgtccagc ggcacctggc tatactggta cttcgatatc
      361 tggggccctg gcaccccaat caccatctcg tcagcc
//
LOCUS       KCXD01000349             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:9371:6069
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000349
VERSION     KCXD01000349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:9371:6069"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58831.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          111 a          116 c          161 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tggacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000350             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15231:15802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000350
VERSION     KCXD01000350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15231:15802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58832.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          131 c          136 g          114 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc atatgcgctg tctctggagg
      181 ctctatcagc ggtggttatg actggagctg gatccgccag cccccaggga ggggactgga
      241 gtggattggg tatatctatg gtagtcgtgg gggcgccacc tacaacccgt ccctcaagaa
      301 tcgagtcacc atctcaaaag acacgtccaa gaaccagttg tccctgaatc tgaactctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagacag tgttgttact atgatgactt
      421 tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000351             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13430:20448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000351
VERSION     KCXD01000351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13430:20448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58833.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       439..444
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          115 c          153 g          115 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cactgtgaag tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtgcagtctc tgggttcacc ttcagtggct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggaatgggtg gcggttatat cgaatgatgg
      301 aactaacaaa tactacgcag actctctgaa ggaccgattt agtatctcca gagagaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaactg gaggacacgg ccgtctatta
      421 ctgcgcgaca gatgcgtttg gtagcgggat tgactactgg ggccggggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000352             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11612:4890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000352
VERSION     KCXD01000352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11612:4890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58834.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       430..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          148 c          146 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtca ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggag ttgttgatcc tgtcaatggt gaagaaattc
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtgg cagcggctgg tccaacctct tcaccggttt ggaatcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000353             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:20599:10621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000353
VERSION     KCXD01000353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:20599:10621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..499
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58835.1"
                     /translation="CARAECTGGVCYFDFW"
     D_segment       445..458
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          109 a          120 c          154 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggggtctgg gggaggcctg gttcagcctg
      181 gggggtccct gaaactctcc tgtgaagcct ctggattcac cttcagtggc tatggcatgc
      241 actgggtccg ccaggctcca gggaggggac tggaatgggc ggcagttata tcgtatgatg
      301 gaagtcagaa atactacgca gactctgtga aggaccgact caccatctcc agagacaatt
      361 ccaagaacat agtatatctt caaatgaaca acctgcagtt cgatgacacg gccgtgtatt
      421 actgtgcgag agccgaatgt actggtggtg tctgctactt tgacttctgg gcccagggag
      481 tcctggtcac cgtctcctct gcc
//
LOCUS       KCXD01000354             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:6825:3164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000354
VERSION     KCXD01000354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:6825:3164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58836.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          115 c          150 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 caaccggagg ggtccctgag actctcctgt acagcctctg gattcacctt cagtttctat
      241 ggcttgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 aatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga
      361 gacaattcca tgaacatgct atttcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000355             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15109:19520
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000355
VERSION     KCXD01000355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15109:19520"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58837.1"
                     /translation="CAAGYSGSWNHWYFDFW"
     D_segment       429..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          139 c          146 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcaaagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcagcgaatt gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg ggggtgttga tcctgtatat ggtgaaatga
      301 tacacgttga gaagttccag ggcagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtttttc tgtgcggccg
      421 ggtacagtgg cagctggaac cactggtact tcgatttctg ggggcctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01000356             371 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23793:18654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000356
VERSION     KCXD01000356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 371)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 371)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23793:18654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    15..369
                     /note="immunoglobulin heavy chain variable region"
     V_region        15..369
     V_segment       15..308
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <300..>338
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58838.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       319..328
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       329..369
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        370..>371
                     /gene="IGHG"
BASE COUNT           85 a           90 c          110 g           86 t
ORIGIN      
        1 acatgggcca gtgtgaagtg caactggtgg agtctggagg aggcttggtt cggcctgggg
       61 ggtccctgag actctcctgt tcagcctctg gattcacctt cagtaatttt ggcatccact
      121 gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttacatcg tctgatgaaa
      181 gtaagaaata ctatgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      241 agaatatgct atatcttcaa atgaacaacc tgaagttgga ggacacggcc gtctattact
      301 gtgcgagaga cgcatatggc agcggctgtg actactgggg ccagggagtc ctggtcaccg
      361 tctcctcagc c
//
LOCUS       KCXD01000357             423 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15878:11746
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000357
VERSION     KCXD01000357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 423)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 423)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15878:11746"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    61..421
                     /note="immunoglobulin heavy chain variable region"
     V_region        61..421
     V_segment       61..351
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <343..>390
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58839.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       354..369
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       373..421
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        422..>423
                     /gene="IGHG"
BASE COUNT           83 a          102 c          135 g          103 t
ORIGIN      
        1 acatgggagt ctgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt
       61 gaggtgcagg tggtggagtc tgggggcggc ttggcaaagc ctgggggatc cctgagactc
      121 tcctgtgcag cctctggatt caccttcagt acctatgcta tgcactgggt ccgccaggct
      181 ccagggaagg ggctggagtg ggtctcagcc attagtgttg gtggtagtac atattacgca
      241 gactccgtga ggggccgatt caccatctcc agagacaact cagagaacac gctctccctg
      301 caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgtgcgaa aggggataca
      361 gctacagttt attacggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca
      421 gcc
//
LOCUS       KCXD01000358             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14461:12260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000358
VERSION     KCXD01000358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14461:12260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58840.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          120 c          144 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgaact gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgaagctctc ctgtgcagcc tctgagttca ccttcagtga ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000359             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6025:12680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000359
VERSION     KCXD01000359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6025:12680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58841.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          131 c          139 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtctc tcacctgcgg tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatctatgg gagggatagt agtaccaagt acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagtgct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000360             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23220:11492
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000360
VERSION     KCXD01000360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23220:11492"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58842.1"
                     /translation="CARDVYGCGLDYW"
     D_segment       443..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          115 c          151 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga tcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtccacc tggtggaatc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cgccttcagt aggtttggca
      241 tgcactgggt ccgccagact ccaggaaagg ggctggagtg ggtggcagtt atgtcgtctg
      301 atggaagtag gatatactac gcagactctt tgaaagaccg attcaccata tccagagaca
      361 attccaagaa catgctatat cttcaactga acaacctgaa attggaggac gcggccgtgt
      421 attactgtgc gagagatgtc tatggctgtg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000361             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14511:4864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000361
VERSION     KCXD01000361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14511:4864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58843.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       436..443
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          105 a          120 c          154 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggt aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcagct tcagttattt ctacatgagc
      241 tgggtccgtc aggctccagg gaaggggctg gagtggatct caagtattga cagtggtggg
      301 actaccacaa attatgcaga ctccgtgagg ggcagcttca ccatctccag agagaacgcc
      361 aagaacacac tgtatcttca aatggacagc ctgagagctg aggacacggc tgtctattat
      421 tgtgcgagag cgcgcggggt gatcattaca tactttgact cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000362             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12945:3097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000362
VERSION     KCXD01000362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12945:3097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58844.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          141 c          150 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgaaatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tggccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgacg acacggccgt atattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000363             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11117:10577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000363
VERSION     KCXD01000363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11117:10577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..492
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58845.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       419..428
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          148 c          138 g          101 t
ORIGIN      
        1 acatggggag caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt acagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gtaaggcttc tggatacacc ttcaacatct atgccatcaa ttgggtgcga caggcccctg
      241 gacaggggct tgagtggatg ggagggatca tccctcttgt tgatatgaca aactacgcac
      301 agaggttcca gggcagagtc acgattaccg cggacacgtc cacagccaca gccttcttgg
      361 aactgagcag cctgagatct gacgacacgg ccatttatta ctgtgcgaga gcccgggcct
      421 acggtagcgg ctaccgctca gactggttct tcgatgtctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01000364             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24786:14321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000364
VERSION     KCXD01000364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24786:14321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58846.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       423..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          143 c          142 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctctacatgg tgaaatgatg
      301 tacgcagaca acttccaggg cagagtcacc ttgaccgagg acacgtcaac agacacagcc
      361 tacatggagc tgagcagcct gagatctgac gacacggccg tgtattactg tgcgcgcggg
      421 cctattacaa tttttggcgt acttattacg gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000365             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13588:9734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000365
VERSION     KCXD01000365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13588:9734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58847.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          110 a          120 c          158 g          120 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacgctat atcttgaaat ggacagcctg agaactgagg acacggctgt
      421 ctattattgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gccaccgtct cctcagcc
//
LOCUS       KCXD01000366             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22423:19983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000366
VERSION     KCXD01000366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22423:19983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..450
     V_segment       84..375
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58848.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       389..395
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..450
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT          108 a          120 c          133 g           91 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagcgac aggcgcccac tctgaggtcc agctggtgca gtctggggct gaggtgaaga
      121 agcctggggc ctcagtgaag gtctcctgca aggtttccgg atacatctta accgaattat
      181 ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtggatggga agtgttgatc
      241 ctcaatatgg tgaaatgata gacgcagaga aattccaggg cagagtcacc atgaccgagg
      301 acacgtctac agacacagcc tacatggagc tgagcagtct gagatctgag gacacggccg
      361 tgtattactg tgcgacatca tccagcggca cctggctata ttggtacttc gatatctggg
      421 gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01000367             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:18842:13183
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000367
VERSION     KCXD01000367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:18842:13183"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..322
     V_segment       8..249
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <241..>291
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58849.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       260..274
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..322
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>324
                     /gene="IGHG"
BASE COUNT           73 a           83 c           90 g           78 t
ORIGIN      
        1 acatggggac tctcctgtgc agcctctgga ttcaccttca gtgactactg gatgtactgg
       61 gttcgccaga cacctgagca ggggctggag tggatctcag ctattgatag tgctggtagt
      121 agtaccacat actatgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      181 aaaaacacac tgtatcttca gatggacagc ctgagaactg aggacacggc tgtctattac
      241 tgtgcgagag ttccgggcct agtggtattt actggttcgc ttgactactg gggccaggga
      301 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000368             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24501:15135
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000368
VERSION     KCXD01000368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24501:15135"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58850.1"
                     /translation="CAKRGWGGSWNGGHYFDYW"
     D_segment       447..460
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          104 a          129 c          167 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggtcca
      181 gcctgggggg tctctgagac tctcctgtgc agcctctgga ttcactttca gtagctatgc
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattactaa
      301 tggtggtgtt accacatact acgcagactc cgtgaggggc cgattcacca tctccagaga
      361 caactcgatg gacacgctct ccctgcaaat gaacagcctg agagctgagg acacggccgt
      421 gtattactgt gcgaaaagag ggtggggcgg cagctggaac gggggtcact actttgacta
      481 ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000369             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:3926:11184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000369
VERSION     KCXD01000369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:3926:11184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..498
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58851.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       450..458
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>502
                     /gene="IGHG"
BASE COUNT          112 a          116 c          152 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca tctggaggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt aacctctgga ttcaccttca gtagctatgg
      241 catgcactgg gcccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagatttact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagagg agaaatttgg ctacagtttt gacttctggg gccagggagt
      481 cctggtcacc gtctcctcgg cc
//
LOCUS       KCXD01000370             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:16315:13586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000370
VERSION     KCXD01000370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:16315:13586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58852.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          136 c          127 g          111 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcatctgcac tgtctctggt
      181 gattccatca gcaatagcta ctggaactgg atccgccagc cccctgggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggtt gagttctgtg
      361 accgccgcgg acaccgccgt gtactactgc gtgagatatg aggatgagtc cattaactac
      421 cactttgact actggggcca gggagtcctg gtctccgtct cctcagcc
//
LOCUS       KCXD01000371             385 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18848:10398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000371
VERSION     KCXD01000371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 385)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 385)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18848:10398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    17..383
                     /note="immunoglobulin heavy chain variable region"
     V_region        17..383
     V_segment       17..310
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <302..>352
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58853.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       321..337
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       342..383
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        384..>385
                     /gene="IGHG"
BASE COUNT           84 a           94 c          119 g           88 t
ORIGIN      
        1 acatggggtc cagggtgagg tgcaactggt ggagtctggg ggcggcttgg caaagcctgg
       61 ggggtccctg agactctcct gtgtagcctc tggattcacc ctcagtaact actggatgta
      121 ctgggttcgc caggcaccag ggaaggggct ggagtggatc tcagctatta atagtgttgg
      181 tgatagcaca tactatgcag actccgtgaa gggcagattc accatctcca gagagagcgc
      241 caagaacaca ctatatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      301 ctgtgcgaga gtaccgggcc tagtggtatt tactgcttca cttgactact ggggccaggg
      361 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000372             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:16723:16990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000372
VERSION     KCXD01000372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:16723:16990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58854.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          144 c          133 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaagtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt
      181 ctcctgcagg atttccggat acaccttcat cgaattatcc atacactggg tgcggcaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctgtatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctact tggaactgag
      361 cggcctgact tctgaggaca cggccgtgta ttactgtgcg actggcccta ccggcacctg
      421 gaacgcctgg tacctcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000373             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17884:14219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000373
VERSION     KCXD01000373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17884:14219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..513
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58855.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       456..463
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          112 a          131 c          155 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggagac ttggtccagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttatggca
      241 tgacctgggt ccgccaggct ccagggaagg ggctggagtg ggtctcatac attagtattg
      301 gtggtagtaa tagatactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcagagaa aacgctctcc ctgcaaatga acagcctgag acctgaggac acggccatgt
      421 attactgtgc gtcgaaccta cgtggaaaca cctacactta ctggcggtcc tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000374             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16519:9523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000374
VERSION     KCXD01000374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16519:9523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58856.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          112 c          149 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 caagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000375             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19751:3392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000375
VERSION     KCXD01000375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19751:3392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58857.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       403..410
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          140 c          130 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 ggccccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtggcttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gcttgggtac atctatggta gcactgggag caccggctac aacccctcca tcaagagtcg
      301 agtcaccatt tcaacagaca cgtcaaagaa ccacttctcc ctgaagctga gctctgtgac
      361 cgccgcggac accgccgtgt atttctgtgc gagatatgga gatgatagtg ttcattacaa
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000376             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14941:21444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000376
VERSION     KCXD01000376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14941:21444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..342
     V_segment       8..272
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58858.1"
                     /translation="CARWGDSQSIYFFDSW"
     D_segment       273..280
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..342
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           70 a          103 c           90 g           81 t
ORIGIN      
        1 acatgggggt gaggccttcg gagaccctgt ccctcacatg cgctgtctct ggtgactcta
       61 ttaccaatag tcactggtgg aactggatcc gccagccccc agggaaaggg ctggaatgga
      121 ttggatatat cagtggttct actggtagca ccgactatca tccctccctc aagagtcgag
      181 tcaccatttc aacagacacg tccaagaacc acttctccct ggaactgagc tctgtgaccg
      241 ccgcggacac ggccgtgtat tactgtgcga gatggggtga ctcccagtcc atttacttct
      301 ttgactcctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000377             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14269:2349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000377
VERSION     KCXD01000377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14269:2349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58859.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       424..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          143 c          144 g          103 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatccacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg gggtgttgct cctctatatg gtgaaatgat
      301 gctcgcagac aacttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga cgacacggcc gtgtattact gtgcgcgtgg
      421 gcctattaca atttttggcg tacttattac ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000378             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15267:20447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000378
VERSION     KCXD01000378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15267:20447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..398
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58860.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       410..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           91 a          138 c          143 g          104 t
ORIGIN      
        1 atggggaatg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcgggagt
      121 cgggcccagc agtggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcac cagtagtaat tggtggagct ggatccgcca gtccccaggg aagggactgg
      241 aatggattgg gggtgtctat ggtagtggtg ggaataccga atacaacccc tccctcaaga
      301 gtcgagtcac catttcaaag gacacgtcca agaaccagtt ctccctgaag ctgaactctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtacgagaga atggggcgct atagcggcag
      421 ttgggcctgt ccttgcctcc tggggccagg gtgtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000379             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:23927:14215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000379
VERSION     KCXD01000379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:23927:14215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    129..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        129..489
     V_segment       129..422
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <414..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58861.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       429..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          103 a          120 c          149 g          119 t
ORIGIN      
        1 acatggggag cccagcccca gaattcccag gtgtttctgt tcggcgatca gcactaaaca
       61 cagaacatac catggagttt gtgctgagct gggttttcct tgttgctctt ttgaaaggtg
      121 tccagtgtga ggtgcagctg gtggagtctg ggggcggctt ggtaaagcct ggggggtccc
      181 tgagactctc ctgcgcagcc tctggattca gcttcagtta tttctacatg agctgggtcc
      241 gtcaggctcc agggaagggg ctggagtgga tctcaagtat tgacagtggt gggactacca
      301 caaattatgc agactccgtg aggggcagct tcaccatctc cagagagaac gccaagaaca
      361 cactgtatct tcaaatggac agcctgagag ctgaggacac ggctgtctat tattgtgcga
      421 gagcgcgcgg ggtgatcatt acatactttg actcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01000380             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6525:12223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000380
VERSION     KCXD01000380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6525:12223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    156..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        156..522
     V_segment       156..447
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <441..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58862.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       461..467
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..522
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT          132 a          147 c          143 g          102 t
ORIGIN      
        1 acatggggga ggtaaaaaca gatctgtcct tgtccagaga gcatcacaca acaaccacat
       61 ccctccccta cagaagcccc agagcacagc acctcaccat ggactggacc tggaggatcc
      121 tcctcttggt ggcagcagct acaggcgccc actctgaggt ccagctggtg cagtctgggg
      181 ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg caaggtttcc ggatacatct
      241 taaccgaatt atccatacac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg
      301 ggagtgttga tcctcaatat ggtgaaatga tagacgcaga gaaattccag ggcagagtca
      361 ccatgaccga ggacacgtct acagacacag cctacatgga gctgagcagt ctgagatctg
      421 aggacacggc cgtgtattac tgtgcgacat catccagcgg cacctggcta tactggtact
      481 tcgatatctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01000381             352 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15737:10188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000381
VERSION     KCXD01000381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 352)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 352)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15737:10188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..350
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..350
     V_segment       7..289
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <281..>319
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58863.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       299..304
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       308..350
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        351..>352
                     /gene="IGHG"
BASE COUNT           83 a           82 c          105 g           82 t
ORIGIN      
        1 acatggggtg gagtcgggag gaggcttggt tcagccgggg gggtccctga gactctcctg
       61 tgcagcctct ggattcacct tcactaccta tggcatccac tgggtccgcc aggctccagg
      121 gaaggggctg gagtgggtga cagttatatc gtatgatgaa acaaagaaat actacgcaga
      181 ctctctgaag gaccgcttca tcatctccag agacaattcc aagaatatgg tatatcttca
      241 aatgaacaac ctgaaattgg aggacacggc cgtatattac tgtgtgagag atgttagggg
      301 aacggggttt gacttctggg gccagggtgt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000382             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24286:10878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000382
VERSION     KCXD01000382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24286:10878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58864.1"
                     /translation="CSTGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>511
                     /gene="IGHG"
BASE COUNT          117 a          150 c          141 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct ccgtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gttaatggtg acctaataca
      301 cgcagacaag ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga cacggccatc tactactgtt cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag tctcttcagc c
//
LOCUS       KCXD01000383             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:11357:11991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000383
VERSION     KCXD01000383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:11357:11991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..494
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58865.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       414..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          109 a          136 c          146 g          109 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga ggcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctctg ccatcagttg ggtgcgacag gcccctggac
      241 aaggacttgg gtggatggga gggatcatcc ctcttgttgg tatgacaaac tacgaacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc ttcatggaac
      361 tgagcagcct gagatctgag gacacggccg tctactattg tgcgacaggg gtatattacc
      421 aggatgaata cggttatttt tatgtcggcg gtgactttga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01000384             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:19003:9481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000384
VERSION     KCXD01000384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:19003:9481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58866.1"
                     /translation="CARWGTPFDYW"
     D_segment       401..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           93 a          132 c          131 g          101 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga agcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcttg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tagctccatc aacagtggtt atgcctggag ctggatccgc cagcccccag agaaggggct
      241 ggagtggatt gggcatatct atgatagtag tgggaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga agctgagatc
      361 tgtgaccgcc gcggacacgg tcgtgtatta ttgtgcgaga tgggggaccc cctttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000385             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14520:6920
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000385
VERSION     KCXD01000385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14520:6920"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..445
     V_segment       100..390
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58867.1"
                     /translation="CAWGGGFDVW"
     D_segment       395..401
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..445
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           80 a          133 c          134 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tgatgaagcc ttcggagacc ctgttcctca cctgcgctgt ctctggtggg
      181 tccatcagca gtaactactg gagctgggtc cgccagcccc cagggaaggg actggagtgg
      241 attggacgtt tctatggtag tagtgggagc accacctaca acccctccct caggagtcga
      301 gtctccattt caacagacac gtccaagaac cagttctccc tgaacctgaa ctctgtgact
      361 gtcgcggaca cggccgtata ttactgtgcg tggggcggtg ggttcgatgt ctggggtccg
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000386             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2466:14017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000386
VERSION     KCXD01000386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2466:14017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58868.1"
                     /translation="CAKTYYSGTLEFW"
     D_segment       420..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..477
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           94 a          146 c          130 g          109 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggggcag aggtgagaag gcccggggag tctctgagga
      181 tctcctgtaa gacttctgga tacagcttta ccaccagctg ggtcagttgg ttgcgccaga
      241 tgcccgggaa aggcctggag tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccctc cttccaaggc cacgtcacta tctcagtcga caactccatc agtaccacct
      361 acctgcattg gagcagcctg aaggcctcgg acaccgccac atatttctgt gcgaaaacct
      421 actatagtgg tactttggag ttctggggcc agggagccct ggtcaccgtc gcctcagcc
//
LOCUS       KCXD01000387             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20199:3511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000387
VERSION     KCXD01000387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20199:3511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58869.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       405..411
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          135 c          134 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggg ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaga gagtactatt ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggctac atctatggta acattgggag caccagctat aacccgtccc tccagagtcg
      301 agtcaccgtt tcaatagaca cgtccaagaa tcacttctcc ctgaagttga cgtctgtgac
      361 cgccgcggac acggccgtat atcactgtgc gagacatctc tattcctgga aagggaagtg
      421 gatcgatgtc tggggcccgg gagtcctgat caccgtctcc tcagcc
//
LOCUS       KCXD01000388             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8816:9952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000388
VERSION     KCXD01000388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8816:9952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58870.1"
                     /translation="CTRKSDTIVAANFHYW"
     D_segment       407..412
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           95 a          142 c          128 g          105 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacatgcgct gtctctggtg
      181 gctctatcag cagtagtaac tggtggacct ggatccgcca gcccccaggg aaagggctgg
      241 agtggattgg gtatatcagt ggtaacagta gtcgcaccca ctacaacccc tccctcagga
      301 gtcgagtcac tttttcaaca gacacgtcca agaaccactt ctccctgaac ctcagctctg
      361 tgaccgccgc ggacacggcc gtttattttt gtacgaggaa atcagatacg atcgtagccg
      421 ctaactttca ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000389             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15538:16163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000389
VERSION     KCXD01000389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15538:16163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58871.1"
                     /translation="CVRELSPYDYFWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           95 a          146 c          132 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaaac cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgt gagagagctt tccccctacg actatttttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000390             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:25489:16546
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000390
VERSION     KCXD01000390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:25489:16546"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58872.1"
                     /translation="CATGGLRTPHYW"
     D_segment       400..407
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           82 a          144 c          134 g           95 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 gctccatcag cggttactgg tggtcctgga tccgccagcc cccagggaag gggctggagt
      241 ggattgggta tatcggtggt actagtggga gcacctacta caacccctcc ctcaagagtc
      301 gagtcacctt ttcaacagac acgtccaaga accagttctc cctgaccctg acctctgtga
      361 gcgccgcgga cacggccgta tattactgtg cgaccggagg actacggacc ccccactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000391             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:5148:5138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000391
VERSION     KCXD01000391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:5148:5138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58873.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          140 c          151 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg ggttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000392             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14325:8867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000392
VERSION     KCXD01000392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14325:8867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..286
     V_segment       8..210
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <202..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58874.1"
                     /translation="CARGVDNHHYSDTEFDLW"
     D_segment       232..238
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       252..286
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           73 a           70 c           79 g           66 t
ORIGIN      
        1 acatggggta gctatgacat gcactgggtt cgccaggctc cagggaaggg tctggagtgg
       61 atatcaggta ttaacattgg cggtgacaca tactacccag actctgtgaa gggtcggttc
      121 accatctcca gagacaatgc caagaactcc ttgtatcttc aaatgaacag cctgagagct
      181 gaggacactg ctgtatatta ttgtgcaaga ggcgtagata accaccacta cagtgatacg
      241 gagtttgacc tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000393             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22525:5540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000393
VERSION     KCXD01000393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22525:5540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..517
     V_segment       142..434
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58875.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       437..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..517
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          105 a          127 c          160 g          127 t
ORIGIN      
        1 acatgggggc agctctgaga caggagcctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtc tgaggtgcag ctggtggagt ctgggggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcagctttgg cgatcatggc
      241 atgcactggg tccgccaggc tccgggaaag ggactggagt gggtctcatc catcagtaat
      301 actggtaaag ccgtacacta cgctgactcc gtgaagggcc gattcaccat ttccagagac
      361 aacgccaaga actcgctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtg
      421 tattattgtt gtagcgatta ctatagtggt agttattact attggggcta cggcttggat
      481 tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000394             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:23574:6201
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000394
VERSION     KCXD01000394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:23574:6201"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58876.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          115 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 ttagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagagatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01000395             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14813:10993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000395
VERSION     KCXD01000395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14813:10993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58877.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          113 c          157 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagtagtgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctggctg ttgaatcgca
      301 tgatggaaat aagaaatact atgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaactggtgg atatggccat
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000396             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18847:6867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000396
VERSION     KCXD01000396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18847:6867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..489
     V_segment       120..413
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58878.1"
                     /translation="CTRAGIQPQPDEGDFDYW"
     D_segment       416..424
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          141 c          134 g           94 t
ORIGIN      
        1 acatgggact caacaactgc atccaacctc aagagaagcc cctgagagca cagtttctca
       61 ccatggactt gacctggaag atcctcctct tggtgacagc agccacaggt gcccactccc
      121 aggtgcagct ggtgcagtct ggggctgaga ttaagcagcc tggggcctca gtgaaggtct
      181 cctgcaaggc ttctggatat ttcttcccta actacgacat acactgggtg agacaggccc
      241 cgggacaagg ccttgagtgg ataggactga tctcccctta caatggtcac agaggctacg
      301 cacagaactt ccaggacaga gtcaccataa ctacggacac gtccacgggc atggcctaca
      361 tggagctgag cagcctgaga tctgaggaca cagccatata tttctgtacg agagcgggga
      421 tacaaccaca gccagacgag ggggactttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01000397             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10925:7780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000397
VERSION     KCXD01000397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10925:7780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58879.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           94 a          148 c          132 g          113 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaaac cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactcc aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagctt tccccctacg actatttttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000398             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17962:6518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000398
VERSION     KCXD01000398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17962:6518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58880.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          112 c          157 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtcgt agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgag tcgcatgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggtggatacg gccatgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000399             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19084:12775
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000399
VERSION     KCXD01000399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19084:12775"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58881.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       403..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           90 a          141 c          130 g          107 t
ORIGIN      
        1 acatggggtt ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtgtcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcacca gtagcttctg gaactggatc cgccagcccc cagggaaggg actggagtgg
      241 attgggtcta tctatggtgc tactgggagc accacctaca accccgccct caagagtcga
      301 gtcaccattt caacagagac gtccaagaac cagttttccc tgagactgag ctctgtgacc
      361 gccgcggaca ccgccgtgta ttactgtgcg agatatgacg acgatgatta cggttcctat
      421 taccttgact actggggcca gggagtcctg gtccccgtct cgtcagcc
//
LOCUS       KCXD01000400             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:19839:3769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000400
VERSION     KCXD01000400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:19839:3769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58882.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          115 a          122 c          144 g          129 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggtggagt ctgggggagg cttggtacag
      181 cctggggcgt ccctgagact ctcctgtgca gcctctgaat tcaccttcag tggctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctagaat ggctatcagg tattaacatt
      301 ggcggtgacc catactaccc agactctgtg aagggtcgat tcaccatctc cagagacaac
      361 gccaagaact ccttgtatct tcaaatgaac aacctgagac ctgaggacac tgctgtgtat
      421 tattgtgtga gggggatgga taactaccac ttcagtaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000401             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13397:8657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000401
VERSION     KCXD01000401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13397:8657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58883.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       441..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          108 a          123 c          156 g          120 t
ORIGIN      
        1 acatggggtc tgagagagga gccttagccc tggatttcaa ggcacttcca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttgggactga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggagg cttggtccag
      181 cctggagggt ctctgagact ctcctgtgta gcctctggat tcagcttcag aagttacgac
      241 atgagttggg tccgccaggc tccgggaaag gggctggagt gggtctcata tattagtcac
      301 actggtgaaa ccatatacca cgctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga attcgctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtc
      421 tattactgca ctaggaaccg gaatactgtt atgattgggt ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000402             406 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9266:20176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000402
VERSION     KCXD01000402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 406)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 406)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9266:20176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    50..404
                     /note="immunoglobulin heavy chain variable region"
     V_region        50..404
     V_segment       50..343
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <335..>373
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58884.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       345..349
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       358..404
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        405..>406
                     /gene="IGHG"
BASE COUNT           86 a           89 c          126 g          105 t
ORIGIN      
        1 acatgggagc tgggttttcc ttgttgctat tttaagaggt gtccagtgtg aggtgcagct
       61 ggtggagtct ggaggaggct tggttcagcc tggggggtcc ctgagactct cctgtgcagc
      121 ctctggattc accttcagta tatctggcat gcactgggtc cgccaggctc cagggaaggg
      181 gctggagtgg gtgtcagtta tatcgtctga tggaagtaag aaatactacg cagactctgt
      241 gaaggaccga ttcaccatct ccagagacaa ttcaaaaaac atggtatatc ttcaaatgaa
      301 caacctgaaa ttggaggaca cggccgtgta tttctgtgtg agagatgcct tcgggggcgg
      361 tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01000403             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6107:22056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000403
VERSION     KCXD01000403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6107:22056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..363
     V_segment       1..287
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <279..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58885.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       293..312
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       314..363
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           72 a          105 c          105 g           83 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg
       61 tctctggtgg ctccatcagc agtagtacct ggtggaactg ggtccgccag cccccaggga
      121 aaggcctgga gtggatagga tatatcaatg gtgagagtgg tagcacctac tacaatccct
      181 ccctcgagag tcgaatcacc atttcaacag acacgtccac gaaccagttt tccctgaggc
      241 tgagctctgt gaccgccgcg gacacggccg tgtatttctg tgcgagaggt tcctatagtg
      301 gtagttatta cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01000404             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4721:16448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000404
VERSION     KCXD01000404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4721:16448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58886.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       440..444
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          120 c          147 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gctgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggagtctgg aggaggcttc attcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cctcagtacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaggaa atactacgca gactctttga aagcccgatt caccatatcc agagacaact
      361 ccaagaacat agtatatctt caattgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtgtat ggctcggggc ttgactactg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000405             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5405:5817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000405
VERSION     KCXD01000405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5405:5817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58887.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          143 c          136 g           99 t
ORIGIN      
        1 acatggggca gcatcacaca acagccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct gcaggcgccc
      121 gctctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg cgaggtttcc ggatatacct tcaccgaact gtccattcat tgggtgcgac
      241 aggcccctgg aaaaggcctt gagtggatgg gaagtgttga tcctgaatat ggtgaaatga
      301 taaacgcaga aaaattccag ggcagagtca ccttgaccga ggacacgtct acaggaacgg
      361 cctacatgga cctgatcagt ctgagatctg aagacacggc cgtgtattac tgtgcgacat
      421 cacccagcgg cacctggcta tattggtact tcgatttctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01000406             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27423:10533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000406
VERSION     KCXD01000406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27423:10533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..468
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58888.1"
                     /translation="CARADYGSSLLPEYFDFW"
     D_segment       398..410
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..468
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>472
                     /gene="IGHG"
BASE COUNT           89 a          151 c          130 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc actaacttct ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgc atctctggta ttgctgggaa caccgactac aacccctccc tcaagagtcg
      301 agtctccatt tcaaaagaca cgcccacgaa ccatttctcc ctgaggctga actctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagagcggac tacggtagca gcttgctccc
      421 tgaatacttc gatttctggg gccagggcgc cctggtcacc gtctcctccg cc
//
LOCUS       KCXD01000407             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:22708:5476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000407
VERSION     KCXD01000407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:22708:5476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..483
     V_segment       117..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58889.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       422..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          118 a          138 c          135 g           94 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg aaggtctcct
      181 gcaaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga caggcccctg
      241 gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg atagacgcag
      301 agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg
      361 agctgagcag tctgagatct gaggacacgg ccgtgtatta ctgtgcgaca tcatccagcg
      421 gcacctggct atactggtgc ttcgatatct ggggccctgg caccccgatc accatctcct
      481 cagcc
//
LOCUS       KCXD01000408             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15821:8296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000408
VERSION     KCXD01000408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15821:8296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58890.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          119 a          141 c          133 g           96 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagagt tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagttga gcagcctaag atctgaggac acggccctgt attattgtgc agtcgggtat
      421 agcggccgat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01000409             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22038:4058
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000409
VERSION     KCXD01000409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22038:4058"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58891.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       257..262
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           79 a           78 c           88 g           74 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agccactgga ttcaccttca gtaactatgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      121 tgatggaagt aagaaatact acgcaaactc tgtgaaggac cgattcacca tctccagaga
      181 caattccaag aacatactct atcttcaaat gaacaacctg aaattggagg acacggccgt
      241 ctattactgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      301 ggtcatcgtc tcctcagcc
//
LOCUS       KCXD01000410             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24594:9014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000410
VERSION     KCXD01000410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24594:9014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58892.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          142 c          135 g          105 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccgcctggtg cagtccggga ctgaggtgaa gaagcctggg gcctcagtga
      181 agatttcctg cggggcttct ggtttcaccc tcgacaccta tggtatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat cccccttatt ggtatcacca
      301 actacgcaga aaactctcag ggcagactca caataaccgc gaacacgtcc acaaatacag
      361 tctatatgga actgagcagt ctgagatctg aggacacggc catctattac tgtgcgagag
      421 aatactgtac ttctagtact tgcgccgggt tccttgacta ctggggccag ggagccctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000411             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11040:10044
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000411
VERSION     KCXD01000411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11040:10044"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58893.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       400..406
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           81 a          138 c          146 g           98 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc aacttcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttttcggtg gtcgcaatgg gaacacctac tacaccccct ccctcaagag
      301 tcgagtcacc atttcaccag acacgtccaa gaaccagttc tccctgaggc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagggag gggatatcag cggcgggggt
      421 cgactactgg ggccagggag ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000412             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12574:20191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000412
VERSION     KCXD01000412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12574:20191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..467
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58894.1"
                     /translation="CARYDQWDDSLYYFDYW"
     D_segment       407..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>470
                     /gene="IGHG"
BASE COUNT           91 a          143 c          128 g          108 t
ORIGIN      
        1 acatggggat gtctctgaga gtcatgggcc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccacg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcac cagtacctac tggaactgga tccgccagcc cccagggaag gggctggagt
      241 ggattggatt tatctatggt gctactggga gcaccggcta caacccctcc ctcaagagtc
      301 gagtcaccat ctcaacagac acgtccaaga accagttttc cctgaagctg agctctgtga
      361 ccgccgcgga caccgccgtc tattactgtg cgagatatga tcagtgggat gattccctgt
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcatcc
//
LOCUS       KCXD01000413             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20242:8792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000413
VERSION     KCXD01000413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20242:8792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58895.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>511
                     /gene="IGHG"
BASE COUNT          117 a          150 c          142 g          102 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct ccgtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gttaatggtg acctaataca
      301 cgcagacaag ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga cacggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag tctcttcagc c
//
LOCUS       KCXD01000414             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7801:6603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000414
VERSION     KCXD01000414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7801:6603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58896.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          115 c          149 g          123 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 accggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 cttgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tttctagaga
      361 caattccatg aacatgctat ttcttcaaat gaacaacctg aacttggacg acacggccgt
      421 ctattactgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000415             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:28638:10863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000415
VERSION     KCXD01000415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:28638:10863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58897.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       438..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          115 c          150 g          121 t
ORIGIN      
        1 acatggggga gctctggtag aggaacccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttatt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt acagcctctg gattcacctt cagtagctat
      241 ggcttgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tctgatgaag ataggaaata ctacgcagac tctctgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgaggga tgataatggg gtgcttatcg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000416             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6978:8805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000416
VERSION     KCXD01000416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6978:8805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..484
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58898.1"
                     /translation="CARGLGSSAHFGLDAW"
     D_segment       422..429
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          103 a          141 c          145 g           97 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgat gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cctctggatt cgccttcaac atgtatgccc tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcgtccctc tccttggaac aacaaactcc
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgtccataag tacagtctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctg
      421 ggcagcagcg cccactttgg tttggatgcc tggggccaag gggtcgtcgt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000417             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6528:20015
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000417
VERSION     KCXD01000417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6528:20015"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58899.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          130 c          137 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcactg tctctggtgg
      181 ctctgtcagc agtagttact ggagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatac atctatggga gtgatagtag taccaaatat aacccctccc tcaagagtcg
      301 agtcaccctg tcagtggaca cgtccaagaa ccaatgctcc ctgaagctga ggtccgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggacagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000418             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14100:15485
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000418
VERSION     KCXD01000418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14100:15485"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58900.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       445..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          115 c          150 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgccca gtgtgaggta caattggtgg agtctggagg aggtttgggt
      181 cagcctgggg ggtccctgag actctcctgt gaaacttctg gattcacctt cagtaattat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tatgatgtaa gtaagacata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcta agaacatgct atatcttcaa atgagcaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgcgagacg cccttggaac gctgactact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000419             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5236:19325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000419
VERSION     KCXD01000419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5236:19325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58901.1"
                     /translation="CTKGRSGGVWPNSFDYW"
     D_segment       431..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          118 a          135 c          143 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagttggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgatt tatccatgca ctgggtgcga
      241 caggccccag gaaaagggct tgagtggatg ggaagtgttg atcctgtata tggtgaaata
      301 attgtcgcag acaatttcca ggacagagtc accatgaccg aggacacgtc taccgacaca
      361 gcctacatgg agctgagcag cctggaatct gacgacacgg ccatgtatta ctgtacgaaa
      421 gggaggagtg gtggtgtctg gccgaactcc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000420             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20243:16717
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000420
VERSION     KCXD01000420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20243:16717"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58902.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       443..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          112 c          148 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctgtttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggagacttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact atggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtctgatgc
      301 aagtaagaca tactacgcaa actctgtgaa ggaccgattc accatattaa gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gacgatatgg gaagtggctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000421             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18255:12837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000421
VERSION     KCXD01000421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18255:12837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58903.1"
                     /translation="CARWGTPFDFW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           84 a          136 c          132 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcgctg tctctggtag
      181 ctccatcaac agtggttatg cctggagttg gatccgccag cccccaggga aggggctgga
      241 gtgggttggg catttctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaagg acacgtccaa gaaccaattc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tctatttctg tgcgagatgg gggaccccct ttgacttctg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000422             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18903:18938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000422
VERSION     KCXD01000422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18903:18938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58904.1"
                     /translation="CASGKRQLDLDYW"
     D_segment       399..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           89 a          134 c          136 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag ccacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agttactact ggaactggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggcat atctatggta gtggtagtga caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccaggtctcc ctgaagctga ggtctgtgac
      361 cgccgcggac acggcctttt attactgtgc gagtgggaag cggcagctgg accttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000423             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7082:8380
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000423
VERSION     KCXD01000423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7082:8380"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58905.1"
                     /translation="CARVRGFTIHYFDYW"
     D_segment       407..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           89 a          139 c          135 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatcagtgg gagtagtggg agtaccgact acaagtcctc cctcaacagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagctct ccctgagact gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtcc ggggctttac tatccactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000424             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5835:11883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000424
VERSION     KCXD01000424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5835:11883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58906.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       412..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          139 c          134 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tttctggtga
      181 ctccatcaac agtggctact actggagctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tatgtcggtg gtggtagtgg catcacctac tacaaatcat ccctcaagag
      301 tcgagtcacc ctctcaaaag acacgtccag gaaccagttc tccctgaaac tgagcgctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaaaa cttccaggtc tgcaactaac
      421 cggtttcgat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000425             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14949:10530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000425
VERSION     KCXD01000425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14949:10530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58907.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       433..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          146 c          142 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tccccaacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgagcaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggac ttgttgatcc tgtaaatggt gaactaatac
      301 acgcagacaa gttccagggc agagtcacca tgaccgaaga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg acatctgagg acacggccat ctactactgt gcgacaggga
      421 ggatcggtac cagtggctgg tccaacctct tcaatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01000426             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17439:5688
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000426
VERSION     KCXD01000426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17439:5688"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58908.1"
                     /translation="CARDAYGRGFDSW"
     D_segment       438..445
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          110 c          154 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 tagaacacag aggactcacc atgaagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccaatgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcccg
      181 gggggtccct gagactctcc tgtgcagcct ctggatacac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggccgttata tcgtatgatg
      301 aagataagaa ataccatgca gactctgtga aggacagatt caccatctcc agagacaatt
      361 cgaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccttgtatt
      421 actgtgcgag agatgcttac ggtagggggt ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000427             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13634:18819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000427
VERSION     KCXD01000427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13634:18819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..483
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58909.1"
                     /translation="CANGMSGLDYW"
     D_segment       428..432
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          104 a          119 c          153 g          109 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatcctt gagactctcc tgtgcagcct ctggattcac cttcagtcgc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcaggtatt agtagtggtg
      301 gtaacacata cctcgcagac tccgtgaagg gccgattcac catctccaga gacgactcaa
      361 agaacacagt ctccttgaaa atgaacagtc tgagacctga agacacggcc gcgtattact
      421 gtgcgaatgg gatgtcaggg cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01000428             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20039:8246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000428
VERSION     KCXD01000428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20039:8246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..465
     V_segment       96..389
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58910.1"
                     /translation="CVRESYSGNYYFNRFDVW"
     D_segment       396..414
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..465
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           93 a          134 c          133 g          107 t
ORIGIN      
        1 acatggggct gagagtcacg gacatcctgt gcaagaacat gaagcacctg tggttcttcc
       61 tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag gagtcgggcc
      121 caggactggt gaagcctttg gagaccctgt ccctcacctg cgctgtctct ggtggctcca
      181 gtagcaataa ttactggagc tggatccgcc agtccccagg gaagggactg gagtggattg
      241 gacatatctc tggtagtggt gggaggaccg actacaaccc ctccctccag agtcgagtca
      301 ccatttcaac tgacacgtcc aagagccagt tctccctgaa gttgagctct gtgaccgccg
      361 cggacacggc cgtctattac tgtgtaagag agtcatatag tggtaattat tacttcaacc
      421 ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000429             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6756:11934
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000429
VERSION     KCXD01000429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6756:11934"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58911.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          113 c          156 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggtttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tctggcatgc
      241 actgggtccg ccaggctcca gggcaggggc tggaatgggt ggcagttgaa tcgtttgatg
      301 gaggtaagaa atactacgct gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000430             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11227:19468
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000430
VERSION     KCXD01000430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11227:19468"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58912.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          118 c          161 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctcc ggtattaata
      301 gtggtgggga aactacatac tacgcagact ccgtgaaggg ccgattcacc atctctagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000431             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6779:17006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000431
VERSION     KCXD01000431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6779:17006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58913.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          117 a          114 c          161 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcccggggg gtcactgaga ctgtcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga atgggaggca cttatatcta
      301 atgatggaag taagaaatat tacgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctg tatcttcaaa tgaacaacct gaaattggat gacacggccg
      421 tgtattactg tgcgcgagtt ggagagggta gtggtggtgc ggaggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000432             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10261:10059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000432
VERSION     KCXD01000432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10261:10059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58914.1"
                     /translation="CARGSNVWVPDFDYW"
     D_segment       429..436
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          117 a          133 c          143 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagcgtc accgaattat gcatacactg ggtgcgacag
      241 gcccctggaa aagtccttga gtggatggga agtgttgatc ctgtaaatga ggcaataata
      301 gacgctgaga acttccaggg cagactcacc atgaccgagg acacgtctac tgacacagcc
      361 tacatggagc tgaggagcct gagatctgag gacacggccg tgtattattg tgccagaggg
      421 agcaacgtgt gggtaccgga ctttgactac tggggccagg gagtcctggt caccgtctct
      481 tcagcc
//
LOCUS       KCXD01000433             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10096:4314
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000433
VERSION     KCXD01000433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10096:4314"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58915.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       447..452
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          104 a          125 c          155 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagtt aatggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggcgtgg atctcaggta ttaacgctgg
      301 tggggatacc acatactatg cagactccgt gaagggcaga tccaccatct ccagagagaa
      361 cgccaggaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgtg agagatcgac gtgttcagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000434             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:2521:12190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000434
VERSION     KCXD01000434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:2521:12190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..474
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58916.1"
                     /translation="CAIGPSGSWNNWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..474
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>480
                     /gene="IGHG"
BASE COUNT          108 a          142 c          137 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 cctgaggtcc ttcttatgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgagctgt ccattcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga agtgttgatc ctgtatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgtg tattattgtg cgattggccc tagcggcagc
      421 tggaacaact ggtccttcga tatctggggc cctggcacac caatcaccat ctccgcagcc
//
LOCUS       KCXD01000435             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12405:13644
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000435
VERSION     KCXD01000435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12405:13644"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58917.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       405..411
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          136 c          133 g          102 t
ORIGIN      
        1 acatgggggt tctctgagaa ccacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggg ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaga gagtactatt ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggctac atctatggta acattgggag caccagctat aacccgtccc tccagagtcg
      301 agtcaccgtt tcaatagaca cgtccaagaa tcacttctcc ctgaagttga cgtctgtgac
      361 cgccgcggac acggccgtat atcactgtgc gagacatctc tattcctgga aagggaagtg
      421 gatcgatgtc tggggcccgg gagtcctgat caccgtctcc tcagcc
//
LOCUS       KCXD01000436             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17011:8174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000436
VERSION     KCXD01000436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17011:8174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58918.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          112 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttaccattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcggttata tcgaatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt cagcgtttcc agagacaatt
      361 cgaagaacat ggtatatctt caaatgaaca ccctgaaatt ggaggacacg gccgtgtttt
      421 actgtgcgac agatgcgttt ggtagcggga ttgaccactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000437             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16412:5077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000437
VERSION     KCXD01000437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16412:5077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58919.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..451
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          150 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga actttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactttg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta attctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01000438             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17910:17479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000438
VERSION     KCXD01000438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17910:17479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58920.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          111 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagtaacg
      241 gcatgcactg ggtccgccag gttccaggga aggggctggg gtgggtggca gtgacatcgt
      301 ttgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000439             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:17302:19716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000439
VERSION     KCXD01000439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:17302:19716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58921.1"
                     /translation="CAAGHSGTWIHWYFDLW"
     D_segment       430..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          146 c          138 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcaa caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacagctt caccgagtta tccattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggcgttgat cctgcatatg gtgaatttac
      301 acccggagag aagttccagg gcagagtaac aatgaccgag gacacgtcta tagacacagc
      361 ctacatggaa ctgagcagcc tgaactctga ggacacggcc gtctattact gtgcagccgg
      421 gcacagcggc acctggatcc actggtactt cgatctctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000440             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11078:13388
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000440
VERSION     KCXD01000440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11078:13388"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58922.1"
                     /translation="CTGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          106 a          130 c          156 g          105 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctact
      241 ggatgaactg ggtccgccag gctccaggaa agggactgga gtgggtctca gctattaata
      301 gtgatgggga gaacacatac tacgcagact ccgtgaaggg ccgattctcc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct gagaccggag gacacggccg
      421 tgtattactg cacgggcggg gcatacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc gtcagcc
//
LOCUS       KCXD01000441             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14033:12804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000441
VERSION     KCXD01000441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14033:12804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..484
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58923.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       409..413
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          107 a          144 c          136 g           99 t
ORIGIN      
        1 acatggggga accacatccc tcctctaaag aagcccctgg gagcacagct catcaccatg
       61 gactggacct ggaggctcct ctttgtggtg gcagcagctg caggtgtcca gtcccaggtc
      121 cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa aatttcctgc
      181 ggggcttctg gattcacctt cgacacccat ggtatcaact gggtgcgaca ggcccctgga
      241 caaggacttc agtggatggg agtgatcatc ccccttattg gtatcaccaa ctacgcaaag
      301 aactctcagg gcagagtcac actaaccgcg gacacgtcca caaacacagc ctacatggag
      361 ctgaacagcc tgagatttga ggacacggcc atctactact gtgcgagaga acgctgcact
      421 tctagtgttt gcgccgggtt ccttgactcc tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000442             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:24534:11816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000442
VERSION     KCXD01000442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:24534:11816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58924.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           85 a          136 c          138 g          104 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 tttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tcaccaggga aggggctgga
      241 gtggattggg tttttcggtg gtagtggtgg gaacacctac tacaagtcgt ccctccagag
      301 tcgagtcacc atttcaaccg acacgtccaa gaaccagttc tccctgacac tgacctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat
      421 tgattactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000443             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:22961:14859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000443
VERSION     KCXD01000443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:22961:14859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58925.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          117 a          113 c          154 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctatg
      241 gcataaactg ggtccgccag gctccaggga aggggctgga gtgggtggga attgtttcgt
      301 ttgatggaac taagagatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaaatcgaa gacacggccg
      421 tgtattatag tacgagagta gactgtagtg gtggtgtctg ctactttgac cactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000444             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10553:10969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000444
VERSION     KCXD01000444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10553:10969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58926.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       448..456
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgagg ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcgttcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaaa taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaccatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gtcagaggcg gtggctttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000445             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24765:9367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000445
VERSION     KCXD01000445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24765:9367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58927.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          113 a          112 c          159 g          116 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tgtattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01000446             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17901:15459
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000446
VERSION     KCXD01000446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17901:15459"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58928.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       441..446
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          107 a          113 c          158 g          120 t
ORIGIN      
        1 acatggggct ctgggggagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggcgg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgta gcctctggat tcaccttcag tagtagtggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt ggctggctgt tgaatcgcat
      301 gatggaaata agaaatacta tgcagactcc gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatggtata tcttcaaatg agcaacctga aattggtgga tacggccatg
      421 tattactgtg tgagagatgc ctacgggggc ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000447             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17809:4941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000447
VERSION     KCXD01000447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17809:4941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58929.1"
                     /translation="CARVSGHTEGTVEYFDSW"
     D_segment       447..463
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          117 a          120 c          155 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatatcgtt
      301 tgatggaact aagcaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggggg acacggccgt
      421 acattactgt gcgagagtta gtgggcatac agagggtaca gttgaatact ttgactcctg
      481 gggccaggga accctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000448             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18660:10535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000448
VERSION     KCXD01000448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18660:10535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58930.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          101 a          127 c          155 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actacttcat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaccagtgg
      301 tggggctaac acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagacc acactgtatc ttcacatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgtt agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000449             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:26888:8612
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000449
VERSION     KCXD01000449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:26888:8612"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..423
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58931.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       439..446
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          121 c          145 g          128 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggga ttcccaggtg ttttcattca gagatcagga
       61 ctgaacacac aggactcacc atggagttta tgctgagctg ggttttcctt gtttctatat
      121 taaaaggtgt ccagtgtgtg gagcttctgg tggagtctgg gggaggcttg gtacagcctg
      181 gggcgtccct gagactctcc tgtgcagcct ctgaattcac cttcagtggc tatgacatgc
      241 actgggttcg ccaggctcca gggaagggtc tagaatgggt atcaggtatt aacattggcg
      301 gtgacccata ctacccagac tctgtgaagg gtcgattcac catctccaga gacaacgccg
      361 agaactcctt gttccttcaa atgaacaacc tgagacctga ggacactgct gtgtattatt
      421 gtgtgagggg gatggataac taccacttca gtaatacgga ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000450             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:17736:15987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000450
VERSION     KCXD01000450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:17736:15987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..394
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58932.1"
                     /translation="CASLLNPSSDSW"
     D_segment       400..405
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           83 a          134 c          136 g          102 t
ORIGIN      
        1 acatggggag gtctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag tcttcggaga ccctgtccct cacctgcgct gtttctggtg
      181 gctccatcag gggttactgg tggggctgga tccggcagtc cccagggaag ggtctggagt
      241 ggattggcta tatcggtggc agtagtggga gcacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagatttc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tattcctgtg cgagtcttct aaacccttcg agtgactcct
      421 ggggccaggg agtcctggtc accgtctcgt cagcc
//
LOCUS       KCXD01000451             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:22394:6689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000451
VERSION     KCXD01000451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:22394:6689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58933.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          117 c          149 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttcttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctggggag tccctgacac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaagt aagaaatact acgcagactc tctgaagggc cgattcacca tttccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg caattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000452             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22525:6408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000452
VERSION     KCXD01000452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22525:6408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58934.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          116 c          154 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catccactgg gtccgccagg ctccggggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaaca aagaaattct acgcaggctc tctgaaggac cgcttcatca tctccagaga
      361 caactccaag aacatggtat atcttcaaat gaatagcctg caattggagg acacggccat
      421 atattactgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggtgtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000453             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14478:5596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000453
VERSION     KCXD01000453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14478:5596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58935.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       399..403
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           96 a          148 c          133 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc acttcctact ggacctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggatat atctatgctg atagtgggac caccagctac aacccgtccc tcaagagtcg
      301 agtcaccatt tcaatagaca cgtccaagaa cctctactcc ctgaaactga gctctgtgac
      361 cgccgcggac acggcctttt attactgtgc gagacgtcct actcgcacgc gggttctata
      421 tgaggcgaca ggggaagact ttgactcctg gggccaggga ctcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000454             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:7751:12239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000454
VERSION     KCXD01000454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:7751:12239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58936.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          130 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgagaca ggagtcttag ccctggattc caagaacttc ctctttggga
       61 gcagctctga acacagagga ccatggagct ggggctgagc tgggttttcc ttgttgccat
      121 tttaaaaggt gtccagtgtg aagtggcact ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagaaacac
      301 tggtaaaatc gtatactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgaa cagcctgaga gccgaggact cggccgtcta
      421 ttactgtact cgaattggcg tcggatctct agcaccggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000455             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19208:11782
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000455
VERSION     KCXD01000455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19208:11782"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58937.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       404..410
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..463
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           94 a          135 c          133 g          103 t
ORIGIN      
        1 acatggggtt ctctgagagt cacagacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccagggc tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagag agtactattg gagctggatc cgccaggccc cagggaaggg actggagtgg
      241 attggctaca tctatggtaa cattgggagc accagctata acccgtccct ccagagtcga
      301 gtcaccgttt caatagacac gtccaagaat cacttctccc tgaagttgac gtctgtgacc
      361 gccgcggaca cggccgtata tcactgtgcg agacatctct attcctggaa agggaagtgg
      421 atcgatgtct ggggcccggg agtcctgatc accgtctcct cagcc
//
LOCUS       KCXD01000456             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:12860:7971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000456
VERSION     KCXD01000456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:12860:7971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..448
     V_segment       94..390
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58938.1"
                     /translation="CARWSAANFDYW"
     D_segment       395..401
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           88 a          135 c          133 g           94 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgggc aagaacatga agcatctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga gtcgggccca
      121 ggactggtga agccctcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 aacagtggtt atggctggag ctgggtccgc cagcccccag ggaaggggct ggagtggatt
      241 gggtgtctct atgatagtag tgggaacacg tactacaacc cctccctcaa gagtcgcgtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga acctgaggtc tatgaccgcc
      361 gcggacacgg ccgtctatta ctgtgcgaga tggtcggcag ccaactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000457             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5604:15145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000457
VERSION     KCXD01000457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5604:15145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..476
     V_segment       113..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58939.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       418..426
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          135 c          142 g          105 t
ORIGIN      
        1 acatggggga catgggaaat gttctctgag agtcacggac atcctgtgca agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca
      121 gctgcaggag tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc
      181 tgtctctggt ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa
      241 gggactggag tggattgggt atatctatgg gagtgatagt agtaccaact acaacccctc
      301 cctcaagagt cgagtcaccc tgtcagtgga cacgtccgag aaccagtgct ccctgaagct
      361 gagctctgtg accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt
      421 ggttgcctac agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000458             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14643:13229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000458
VERSION     KCXD01000458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14643:13229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58940.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          115 a          123 c          145 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atggctatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccaagaa ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000459             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:10261:10229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000459
VERSION     KCXD01000459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:10261:10229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58941.1"
                     /translation="CARFGTYEDDYTYYLGSW"
     D_segment       409..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..475
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          101 a          139 c          128 g          109 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacatgcgc tgtctctggt
      181 gactctatca gcaatagtaa ctggtggaac tggttccgcc agaccccagg gaaagggctg
      241 gaatggattg gacatatcag tggtaatact gatagcacct cctacaaccc ctccctcaaa
      301 agtcgagtca ccatttcaac ggacacgtcc cagaaccagt tctccctgaa gctgacctct
      361 ctgaccgccg cggacacggc cgtgtattac tgtgcgagat ttgggacata cgaggatgat
      421 tacacttact atttgggttc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000460             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6761:10191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000460
VERSION     KCXD01000460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6761:10191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58942.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           92 a          137 c          129 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgatg tctctggtgg
      181 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtaatagtgg taccacctac tacaacccct ccctcaagag
      301 tcgagccacc atttcaaaag acacgtccaa caatcaactc tccctgaagc tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat gaagacccct ccatttttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000461             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18137:20240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000461
VERSION     KCXD01000461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18137:20240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..489
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58943.1"
                     /translation="CAAGLGGYLLLTEYLQFW"
     D_segment       431..441
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>496
                     /gene="IGHG"
BASE COUNT          118 a          139 c          138 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggttggg aagtgttgat tataaatatg atgaaattat
      301 acacgcagac aagttccagg acagagtcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc atgtatttct gtgcggcggg
      421 ccttggggga tatttactgc ttactgagta tctccagttc tggggccagg gcgccctggt
      481 caccgtctct tccgcc
//
LOCUS       KCXD01000462             369 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7560:10193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000462
VERSION     KCXD01000462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 369)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 369)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7560:10193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..367
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..367
     V_segment       6..288
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <280..>336
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58944.1"
                     /translation="CARVGGDDYGYYSSSLDYW"
     D_segment       297..316
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       328..367
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        368..>369
                     /gene="IGHG"
BASE COUNT           82 a           84 c          115 g           88 t
ORIGIN      
        1 acatgggggg agtctggagg aggcttggtt cagccggggg ggtccctgag actctcctgt
       61 acagcctctg gattcacctt cagtggctat ggcatgcact gggtccgcca ggctccaggg
      121 agggggctgg agtgggtggc acttatatcg tttgatggaa gtaagaaata ctacgcagac
      181 tctgtgaagg accgattcac catctccaga gacaattcga agaacatgtt atatcttcaa
      241 gtgaacaacc tgaaattgga ggacacggcc gtctattact gtgcgagagt tggcggggat
      301 gattacggtt actattcgag ttcattggac tactggggcc agggagtcct ggtcaccgtc
      361 tcctcagcc
//
LOCUS       KCXD01000463             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:3948:17163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000463
VERSION     KCXD01000463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:3948:17163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58945.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          149 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtcgggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtctttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tacgaaatac tacgcagact ctgtgaaggg ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaataacct gcaattggag gacacggccc
      421 tgtattactg tgcgagagga gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000464             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18700:14338
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000464
VERSION     KCXD01000464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18700:14338"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58946.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       413..422
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          136 c          143 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaagt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaggtgt tgatcctcta tatggtgaaa aaagacacgc
      301 agagaagttc cagggcagag tctccatgac cgaggacacg tctacaaaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtac tattgtgcga gaggatattg
      421 tagcggtagt cactgctcgt ccggatttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000465             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11596:6352
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000465
VERSION     KCXD01000465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11596:6352"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..449
     V_segment       83..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <371..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58947.1"
                     /translation="CARIASTSLGNRFDVW"
     D_segment       388..392
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..449
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT          100 a          143 c          109 g           99 t
ORIGIN      
        1 acatggggga atcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttat cccaggtcac cttgaaggag tctggtcctg cgctcgcgaa
      121 acccacacag accctcacgc tgacctgcac cttctctgga ttctcaatca gcactactgg
      181 aacaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaagcat
      241 ttattggtat gaaagtaaat actatagtac atcgctggag agcaggctca ccctttccaa
      301 ggacacctcc aaaaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc
      361 cacatattat tgtgctcgga tagcatccac ctccctcggc aaccggttcg atgtctgggg
      421 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000466             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:22250:9672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000466
VERSION     KCXD01000466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:22250:9672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..271
     V_segment       8..206
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <199..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58948.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       213..220
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       223..271
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           73 a           63 c           76 g           61 t
ORIGIN      
        1 acatgggatg gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca
       61 gttatatcgt acgatgaaag taagaaatac tacgcagact ctctgaagga ccgattcacc
      121 atctccagag acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaaatggag
      181 gacacggccg tttattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg
      241 ggccaaggac tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01000467             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19794:9966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000467
VERSION     KCXD01000467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19794:9966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58949.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          139 c          138 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattggct ttttcggtgg tagtggtggg agcacctact acaagtcctc cctccagagt
      301 cgagtcacca tttcaaccga cacgtccaag aaccagttct ccctgatact gacctctgtg
      361 accgccgcgg acacggccct ctattactgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000468             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17281:17971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000468
VERSION     KCXD01000468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17281:17971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58950.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           84 a          139 c          136 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tagtggtggg agcacctact acaaatcctc cctccagagt
      301 cgcgtcacca tttcaaccga cacgtccaag aaccagttct ccctaatact gacctctgtg
      361 accgccgcgg acacggccct ctattactgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000469             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11967:14539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000469
VERSION     KCXD01000469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11967:14539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..395
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58951.1"
                     /translation="CATDAEWGLVGTVSRFDVW"
     D_segment       418..424
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..476
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           87 a          136 c          142 g          113 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg ctgtctctgg
      181 tggctctatc agcagtacct actggaactg gatccgccag gccccaggga aggggctgga
      241 gtggattgga tatatctatg gtactggtag tatcaccaac ttcaatccct ccctcaagag
      301 tcgagtcacc ctgtcagttg acacgtccaa gaaccaggtc tccctgaaga tgacctctgt
      361 gaccgccgcg gacgcggccg tgtattactg tgcgaccgat gcggagtggg gtttggttgg
      421 aactgtttcc cggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000470             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10440:18377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000470
VERSION     KCXD01000470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10440:18377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..390
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58952.1"
                     /translation="CATSPYYEDDNLFYPYNWFDVW"
     D_segment       400..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           92 a          144 c          131 g          117 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tttttggtgt
      181 ctccatcaga aataactggt ggtactggct ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggag taccacctac aacccctccc tccagagtcg
      301 agtctccgtt tcaatagaca cgtccaagaa ccagttctcc ctgaagttga actctgtgac
      361 cgccgcggac acggccgtgt tttactgtgc taccagcccg tattacgagg atgataacct
      421 tttctatccc tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000471             407 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27599:7229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000471
VERSION     KCXD01000471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 407)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 407)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27599:7229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..405
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..405
     V_segment       33..326
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <318..>374
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58953.1"
                     /translation="CARYGDDDYSGNDYFFDFW"
     D_segment       342..351
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       362..405
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        406..>407
                     /gene="IGHG"
BASE COUNT           83 a          118 c          116 g           90 t
ORIGIN      
        1 acatgggggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag tcgggcccag
       61 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt ggctccatca
      121 gcagtagcta ctggaattgg atccgccagt ccccagggaa gggactggag tggattgggt
      181 acatctatgg tgctactggg agcaccagct acaacccctc cctcaagagt cgagtcagca
      241 tttcaacaga cacgtccaag aaccagtttt ccctgaacct gaactctgta accgccgcgg
      301 acaccgccgt gtattactgt gcgagatatg gcgacgatga ctatagtggg aatgattact
      361 tctttgactt ctggggcctg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000472             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18854:3710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000472
VERSION     KCXD01000472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18854:3710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58954.1"
                     /translation="CAREFSPYDYFWSDFYFYYFDYL"
     D_segment       431..436
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           96 a          143 c          133 g          117 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agcttccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 gactccttca gcggttacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc atatcagtgg gagtagtggg agcaccgact acaacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag agccacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagt tttcccccta cgactatttt
      421 tggagtgatt tttactttta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01000473             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16418:19667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000473
VERSION     KCXD01000473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16418:19667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..399
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58955.1"
                     /translation="CARDTTFTGRYDYW"
     D_segment       402..408
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           96 a          138 c          130 g          101 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gagtggtgaa gccttcgggg cccctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcatcagtta caggtggacc tggatccgcc agcccccagg gaagggacta
      241 gagtggattg ggtacatcta tggtagtggt acgagcacca actacaaccc ctccctcaaa
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccttgaa gctgaactct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atactacctt taccggcagg
      421 tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000474             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12334:13092
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000474
VERSION     KCXD01000474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12334:13092"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58956.1"
                     /translation="CAKFSSWGDYYDYRGLDSW"
     D_segment       425..443
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT           97 a          143 c          138 g          119 t
ORIGIN      
        1 acatggggag tctccctcac cgtacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggagcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtga gacctctgga tacagtttta acacctactg gatcagctgg gtgcgccaga
      241 tgcccggaaa aggcctggag tggatgggga cgattgatcc tagtgattct gataccagat
      301 acagtccgtc cttccaaggc caggtcacca tctcagccga caagtccatc agtaccgcct
      361 acctgcagtg gaacagcctg aaggcctcgg actccgccac gtattactgt gccaaatttt
      421 cgtcctgggg tgattattat gactatcgcg gtttggattc ctggggccga ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000475             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15247:17145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000475
VERSION     KCXD01000475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15247:17145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58957.1"
                     /translation="CTRIGVGSLATAGAYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          109 a          132 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgagaca ggagcctcag ccctggattc caagaacttc cagtttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcaact ggtgcagtct gggggaggct tggtccagcc
      181 tggggggtca ctgagactct cctgtgcagc ctctggattc acctttggtg attttggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttcgtaacac
      301 tggtaaaacc atatactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tccctgtctc tacaaatgaa cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaattggcg tcggatctct agcaacggct ggtgcctact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000476             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12270:11107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000476
VERSION     KCXD01000476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12270:11107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58958.1"
                     /translation="CVTGRFGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          138 c          149 g           99 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tgggactgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gaaatgtcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagagct tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgt gacagggagg
      421 ttcgggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg tcaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01000477             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:23445:14176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000477
VERSION     KCXD01000477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:23445:14176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..398
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58959.1"
                     /translation="CTTWTTGYNYYFAYFDSW"
     D_segment       418..425
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           95 a          142 c          133 g          108 t
ORIGIN      
        1 acatgggggt tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggagcggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc agcgacacta acaggtggag ttggatccgc cagtccccag ggaagggact
      241 ggagtggatt ggatacatcg atggcacttc tacgcgcacc gactacaccc cctccctcaa
      301 aggtcgagtc accatttcaa aagacacgtc caggaaccag ttctccttga ggctgaattc
      361 tgtgagcgcc gcagacacgg ccgtgtatta ctgtacgact tggacgactg ggtataatta
      421 ttacttcgcc tactttgaca gctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000478             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10066:9449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000478
VERSION     KCXD01000478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10066:9449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58960.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          111 c          153 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaac taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000479             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:3634:14670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000479
VERSION     KCXD01000479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:3634:14670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58961.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       454..463
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          113 a          120 c          158 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatctcgtt
      301 tgatggaact aagcaattct acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atctccaaat gaacaacctg aaattggggg acacggccgt
      421 acattactgt gcgagagtta gtgggcatac ggagggtaca gttgaatact ttgactactg
      481 gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000480             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11327:10900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000480
VERSION     KCXD01000480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11327:10900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58962.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       445..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          113 c          152 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggta caattggtgg agtctggagg aggtttggtt
      181 cagcctgggg ggtccctgag actctcctgt gaagcttctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgtaa gtaggaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcta agaacatgct atatcttcaa atgagcaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgcgagacg cccttggaac gctgactact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcgtc agcc
//
LOCUS       KCXD01000481             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8757:18550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000481
VERSION     KCXD01000481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8757:18550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58963.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       432..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          111 a          143 c          151 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccgct
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggag ttgttgatcc tgtcaatggt gaagaaatat
      301 acgcagagag gttccagggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtag tagcggctgg tccagcctct tcaccggttt ggattcctgg ggccgagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000482             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18394:10254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000482
VERSION     KCXD01000482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18394:10254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58964.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tgttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000483             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:26425:12620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000483
VERSION     KCXD01000483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:26425:12620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58965.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          120 c          145 g          126 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgaact gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgaagctctc ctgtgcagcc tctgagttca ccttcagtga ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtag taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000484             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16681:8671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000484
VERSION     KCXD01000484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16681:8671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..470
     V_segment       113..403
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58966.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       412..421
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           85 a          141 c          142 g          104 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcacggac ctcctgtgca agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca
      121 gctgcaggag tcgggcccag gactggtgaa gccttcggag accctggccc tcacctgcgc
      181 tgtctctggt ggctccatca gtggttactg gtggggctgg atccgccagt ccccagggag
      241 cgggctggaa tggattggat ttttcggtgg tagtggtggg aacacctact acaagtcctc
      301 cctccagagt cgagtcacca tttcagccga cccgtccaag aaccagttct ccctgatact
      361 gacctctgtg accgccgcgg acacggccct ctattactgt gcgcggggga atatagcagc
      421 gactggcatt gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000485             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9792:22659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000485
VERSION     KCXD01000485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9792:22659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58967.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       436..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          111 a          143 c          145 g          104 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca actggtggag tccggggctg aggtgaagaa gcctggggcc tcagcgaagc
      181 tctcctgcaa ggccgctgga tacattttca gtacctctgc catcagttgg ctgcgacagg
      241 cccctggaca agggcttgag tggatggggg gggtcatccc tcttcttggt agaacaaact
      301 acgcacagag gttccaggac agagtcacga ttaccgcgga cacgtccaca accacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtattactgt gcgagcggtg
      421 gtttccagga tgagaacggt tactattttc cagactactt tgacttctgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000486             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22325:8819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000486
VERSION     KCXD01000486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22325:8819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58968.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          110 a          120 c          154 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcacaaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc aggttcaatt attactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaatagtgg
      301 tggggaaagc acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactatatc ttcaaatgga cagcctgata tctgaggaca cggctgtcta
      421 ttactgtgtg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000487             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6517:19415
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000487
VERSION     KCXD01000487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6517:19415"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58969.1"
                     /translation="CANALTGGLDYW"
     D_segment       441..449
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          106 a          122 c          159 g          109 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 caccactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaggtactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctattgcaag
      301 tggtggagaa aacacatact atgcagactc cgtgaagggc cgattcaccg tctccagaga
      361 caactcaaag agcacagtct ccctgcaaat gaacagtctt agaacggagg acacggccgt
      421 gtattactgt gcgaatgcgt taactggggg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000488             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24348:15345
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000488
VERSION     KCXD01000488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24348:15345"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..506
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58970.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       444..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          121 c          155 g          126 t
ORIGIN      
        1 acatggggga gacaggagtc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgg agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg tagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagaa acactggtaa
      301 aatcgtatac tacgctgact ccgtgaaggg ccgattcatc atctccagag acaacgccaa
      361 gaattcgctg tctctgcaaa tgagcagcct gagagtcgag gactcggccg tctattactg
      421 tactagaatt ggcgtcggat ctctagcacc ggctggtgaa tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000489             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23261:14606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000489
VERSION     KCXD01000489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23261:14606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58971.1"
                     /translation="CARGPVTIFGVLITGLDYW"
     D_segment       425..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          142 c          142 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aaggacttga gtggatggga ggtgttgctc ctctatatgg tgaaatgatg
      301 cacgcagaca acttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgac gacacggccg tgtattactg tgcgcgtggg
      421 cctgttacaa tttttggcgt acttattacg gggcttgact actggggtca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000490             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24554:4635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000490
VERSION     KCXD01000490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24554:4635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58972.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          138 c          153 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgacc ctggaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 gggttcggta gcagtgtctg gtccaatctc gtttatggtt tggattcctg gggccaaggg
      481 gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01000491             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21229:14487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000491
VERSION     KCXD01000491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21229:14487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58973.1"
                     /translation="CARDDMGSGFDFW"
     D_segment       417..423
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          109 a          103 c          141 g          114 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgctg ttttaagagg tgtccagtgt gaggtacagc
      121 tggtggagtc tggaggagac ttggttcagc cgggggggtc cctgagactc tcctgtgcag
      181 cctctggatt caccttcagt aactatggca tacactgggt ccgccaggct ccagggaagg
      241 ggctggagtg ggtggcagtt atatcgtctg atggaagtaa gacatactac gcaaactctg
      301 tgaaggaccg attcacgata ttaagagaca attccaagag catgctctat cttcaaatga
      361 acaacctgaa attggaggac acggccgtct attactgtgc gagagacgat atgggaagtg
      421 gctttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000492             424 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9616:3233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000492
VERSION     KCXD01000492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 424)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 424)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9616:3233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    41..422
                     /note="immunoglobulin heavy chain variable region"
     V_region        41..422
     V_segment       41..334
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <326..>391
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58974.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       339..360
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       372..422
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        423..>424
                     /gene="IGHG"
BASE COUNT           87 a          120 c          122 g           95 t
ORIGIN      
        1 acatgggctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
       61 gggcccagga ctgatgaagc cttcagagac cctgtccctc agctgcgctg tctctggtgg
      121 ctccataagt ggtaactggt ggagctggat ccgccagccc ccagggaagg gactggactg
      181 gattggacgt atctctggta ctagtgggga caccaattac aatccctccc tcaagagtcg
      241 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga actctgtgac
      301 cgccgcggac gcggccgtgt attattgtgc aagagcggat tacgaggatg attacggtta
      361 tcatttagga tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      421 agcc
//
LOCUS       KCXD01000493             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13124:15040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000493
VERSION     KCXD01000493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13124:15040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58975.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          119 c          147 g          119 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccgga gtgaggtgca actggtggag tccggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca ctaactatgg
      241 catgcactgg gtccgccagg ctccagggaa gggactggag tgggtggcag ttatttcgtc
      301 tgatggaagt aagaaatact acgcaacctc tgtgagggac cgcttcacca tctccagaga
      361 caattccaag aacatacttt atcttcaaat gaacaacctg aaattggaag acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000494             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12287:16477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000494
VERSION     KCXD01000494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12287:16477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58976.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          117 c          147 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtacagcctc tggattcacc ttcagtacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat cgtatgatga
      301 aactaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtgtatta
      421 ctgtgcgaga gattcttacg gtcgaggctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000495             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21741:11117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000495
VERSION     KCXD01000495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21741:11117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58977.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          112 c          148 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgtagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagaa gagagatttg gctacagttt tgacttctgg ggccagggaa
      481 ttttggtcac cgtctcctca gcc
//
LOCUS       KCXD01000496             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14186:6279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000496
VERSION     KCXD01000496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14186:6279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58978.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       418..437
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          140 c          145 g          108 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata caccttcagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggta gtggttgtaa ccttacattc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01000497             317 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5809:4811
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000497
VERSION     KCXD01000497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 317)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 317)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5809:4811"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..315
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..315
     V_segment       5..254
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <246..>284
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58979.1"
                     /translation="CVRDVYGWGLDYW"
     D_segment       263..269
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..315
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        316..>317
                     /gene="IGHG"
BASE COUNT           74 a           79 c           89 g           75 t
ORIGIN      
        1 acatggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agctttggca
       61 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      121 atgaaagtaa gaaatactac gccgactctt tgaaagaccg attcaccata tccagagacg
      181 actccaggaa catgctatat cttcaactga acaacctgaa attggacgac acggccgtgt
      241 attactgtgt gagagatgtg tatggctggg ggcttgacta ctggggccag ggagtcctag
      301 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000498             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6382:18400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000498
VERSION     KCXD01000498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6382:18400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58980.1"
                     /translation="CAREGISASGVDYW"
     D_segment       398..404
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           81 a          136 c          145 g           99 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcaa cttcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc cccagggaag gggctggagt
      241 ggattgggtt tttcggtggt cgcaatggga acacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaccagac acgtccaaag accagttctc cctgaggctg aggtctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagggaggg gatatcagcg tcgggggtcg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000499             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23843:10629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000499
VERSION     KCXD01000499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23843:10629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58981.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       399..407
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           97 a          135 c          129 g          115 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtt caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagttccca aatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccctcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcagtaac tactggagct ggatccgcca gtccccaggg aagggactgg
      241 agtggatcgg ttatgtctat ggtgatagtg ggaacaccga atacaacccc tccctcaaga
      301 gtcgagtcac catttcaaga gactcgtcca agaatcagtt ttccctgaag ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtatcact gtgcgagata cagttacggt tccaactact
      421 tctttgggtt ctttgactat tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000500             292 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24484:12592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000500
VERSION     KCXD01000500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 292)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 292)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24484:12592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..290
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..290
     V_segment       9..211
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <203..>259
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58982.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       218..235
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..290
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        291..>292
                     /gene="IGHG"
BASE COUNT           70 a           79 c           81 g           62 t
ORIGIN      
        1 acatgggggt tactactgga gctggatccg ccagccccca gggaaggggc tggagtggat
       61 tggatatatc agtgctagta gtggaaacac cgactacaac ccctccctca agagtcgagt
      121 caccatttca acagacacgc ccaagaacca gttctccctg atgctgagct ctgtgaccgc
      181 cgcggacacg gccgtgtatt attgtgcgag agagaaatac tatagtggta gttataaaca
      241 caactggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000501             397 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11779:18780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000501
VERSION     KCXD01000501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11779:18780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..395
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..395
     V_segment       71..333
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <326..>364
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58983.1"
                     /translation="CASNSITSGPDYW"
     D_segment       339..345
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       359..395
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        396..>397
                     /gene="IGHG"
BASE COUNT           79 a          120 c          106 g           92 t
ORIGIN      
        1 acatgggggt tctctgagag gcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgg
      121 ctctatcagc ggtaactact ggagctggat ccgccgggcc ccagggaagg gactggagtg
      181 gattggatat atctacggta gtgattttac caccaactac aacccctccc tcaagagtcg
      241 agtcaccctg tcagcagata cgtccaagaa ccagctctcc ctgaacctgg cctctgtgac
      301 cgccgcggac acggccgtct atttctgtgc cagtaatagt ataacatctg gtccagatta
      361 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000502             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18754:11110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000502
VERSION     KCXD01000502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18754:11110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58984.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          130 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctggctt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgaa atgggtctca tctattagta
      301 gtggtggtct cacatactac gcagactctg tgaagggccg atttgccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag tgctgaggac acggccgtat
      421 attactgtgc gaaaggaggt agcagctctt tctattggta cttcgatatc tggggccctg
      481 gcaccccagt gaccatctcc tcagcc
//
LOCUS       KCXD01000503             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:2760:9299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000503
VERSION     KCXD01000503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:2760:9299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58985.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          116 c          148 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtcca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctcagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000504             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11623:15920
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000504
VERSION     KCXD01000504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11623:15920"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..481
     V_segment       103..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58986.1"
                     /translation="CAKLPLSSGSYYFPGYFDYW"
     D_segment       411..427
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           92 a          141 c          134 g          116 t
ORIGIN      
        1 acatggggat gttctctggg agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca acagtgctta ctactggagt tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtatatcgg tggtcttagt ggtagcacct actacaaccc ctccctcaca
      301 agtcgagtca gcatttcaaa agatacgtcc aagaaccagt tctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgaaat tgcccctttc tagtggcagt
      421 tattactttc ccgggtactt tgactactgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000505             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15987:11618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000505
VERSION     KCXD01000505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15987:11618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58987.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          141 c          150 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccttgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggtgttgatc ctgcaaatgg tgaggaaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 caattcggta ccagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000506             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13378:8092
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000506
VERSION     KCXD01000506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13378:8092"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58988.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       445..451
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          145 c          138 g           99 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gagggtcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc aactggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctcccctgca aggcttctgg atacaccctc agcatctcta ccatcagttg ggtacgacag
      241 gcccctggac aagggcttga gtggatgggg gagatcttcc ctcttgttgg taaaacaaaa
      301 tacgcacaga agttccacgg cagagtcacg attaccgcgg acacgtccgc aagtacagcc
      361 tacatggagc tgagcggcct gaaatctgag gacacggccg tctattactg tgcgaaaaga
      421 ggtggccacg gtaccaccac cacgttgtac ttctttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000507             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10804:10319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000507
VERSION     KCXD01000507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10804:10319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58989.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          123 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtctcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgctgg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000508             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20993:6303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000508
VERSION     KCXD01000508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20993:6303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..363
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58990.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       291..308
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       313..363
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           76 a          102 c          104 g           83 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg
       61 tctctggtgg ctccttcagc ggttactatt ggagctggat ccgccagtcc ccagggaagg
      121 ggctggagtg gattgggtat atcagtgcta gtagtgggag taccgactac aacccctccc
      181 tcaagagtcg agtcaccatt tcaacagaca cgtccaatta ccatttctcc ctgaagctga
      241 cctctgtgac cgccgcggac acggccgtat attactgtgc gagagagaag tactatagtg
      301 gtagttataa acacaactgg ttcgatgtct ggggcccggg agtccaggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01000509             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13860:8541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000509
VERSION     KCXD01000509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13860:8541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58991.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           88 a          141 c          130 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtaatagtgg taccacctac taccacccct ccctcaagag
      301 tcgagccacc atttcaaaag acacgtccag caatcaactc tccctgaagc tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat gaagacccct ccatttttga
      421 ctactggggc cagggcgtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000510             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10657:2634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000510
VERSION     KCXD01000510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10657:2634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58992.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          141 c          132 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaac cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccttggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 cttggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacctcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000511             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18931:14638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000511
VERSION     KCXD01000511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18931:14638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58993.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          142 c          137 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acagccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct gcaggcgccc
      121 gctctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg cgaggtttcc ggatatacct tcaccgaact gtccattcat tgggtgcgac
      241 aggcccctgg aaaaggcctt gagtggatgg gaagtgttga tcctgaatat ggtgaaatga
      301 taaacgcaga aaaattccag ggcagagtca ccttgaccga ggacacgtct acaggaacgg
      361 cctacatgga cctgatcagt ctgagatctg aagacacggc cgtgtattac tgtgcgacat
      421 cacccagcgg cacctggcta tattggtact tcgatttctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01000512             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13804:17856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000512
VERSION     KCXD01000512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13804:17856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    129..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        129..499
     V_segment       129..422
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <414..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58994.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       445..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          101 a          127 c          156 g          119 t
ORIGIN      
        1 acatggggag gagccttagc cctggattcc aagaacttcc actttgggat cagctctgaa
       61 cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt ttaaaaggtg
      121 tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct ggggggtccc
      181 tgagactctc ctgtgcagcc tctggattca cctttggtga ttatggcatg cactgggtcc
      241 gccaggctcc gggaaaggga ctggagtggg tctcatccat taggaacact ggtaaaatcg
      301 tatactacgc tgactccgtg aagggccgat tcaccatttc cagagacaac gccaagaact
      361 cgctgtctct gcgaatgagc agcctgagag ccgaggacac ggccgtgtac tactgtacta
      421 gaattggcgt cggatctctg gcaacggctg gtgactactt tgaccactgg ggccagggag
      481 tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01000513             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21053:8076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000513
VERSION     KCXD01000513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21053:8076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..444
     V_segment       90..383
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58995.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       394..403
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          101 a          104 c          136 g          105 t
ORIGIN      
        1 acatggggag cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc
       61 ttgttgctat tttaagaggt gtccagtgtg aggtgcaact ggtggagtct ggaggaggct
      121 tggttcggcc gggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta
      181 gttttggcat ccactgggtc cgccaggctc cagggaaggg cctggagtgg gtggcagtta
      241 tatcgtctga tgaaagtaag aaatactacg cagactctgt gaaggaccga ttcaccatct
      301 ccagagacaa ttccaagaac atgctatatc ttcaaatgaa caacctgaag ttggaggaca
      361 cggccgtcta ttactgtgcg agagacgcat atggcagcgg ctgtgactac tggggccagg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000514             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14852:3864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000514
VERSION     KCXD01000514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14852:3864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58996.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          114 c          154 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactttg
      241 gcttacactg ggtccgccag gctccaggga agggactgga atgggtggca gttatatcgc
      301 atgatggaaa taagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatggta tatcttgaaa tggacaacct gcaattggag gacacggccg
      421 tgtatttctg tgtgagagat gcctacggta ccgggttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000515             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22614:11737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000515
VERSION     KCXD01000515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22614:11737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58997.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          117 c          156 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagcctgg
      181 ggggaccctg agactctcct gcgcagcctc tggattcagc ttcagttatt tctacatgag
      241 ttgggtccgt caggctccag ggaaggggct ggagtggatc tcaagtattg acaatggtgg
      301 gactaccgca atttatgcag actccgtgag gggcagattc agcatctcca gagagaacgc
      361 caagaacaca ctggatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcacgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000516             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17911:22180
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000516
VERSION     KCXD01000516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17911:22180"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58998.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          136 c          135 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag gtcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtagcttct ggaactggat tcgccagccc ccaggggagg ggctggagtg
      241 gattgggtat atctctggtg ctactgggag taccagctac agcccatccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcg ctgaggctga actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gcggatgatt acggttatta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000517             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16958:3346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000517
VERSION     KCXD01000517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16958:3346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX58999.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          110 c          154 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcttcggg gttcatcttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gtaacatcgt
      301 ctgatgaaag taagaaattc tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccca gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tctactattg tgggagagat gataatgggg tgattattga ctactggggc cagggagtcc
      481 tggtcaccat ctcctcagcc
//
LOCUS       KCXD01000518             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:9991:10238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000518
VERSION     KCXD01000518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:9991:10238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59000.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       441..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          120 a          143 c          146 g           98 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaactggt gcagtctggg gctgaaatga agaagcctgg ggcctcagtt
      181 agggtctcct gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata
      301 atacacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gccttcatgg agttgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgaaa
      421 ggggggttcg gaaccagcgt ctggtccaac ctcttctacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000519             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8358:16011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000519
VERSION     KCXD01000519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8358:16011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59001.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       439..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..503
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          103 a          142 c          148 g          112 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 caccactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttcttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggcg tctgggggcg gcttggcgaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca acacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtac
      301 tgctggtagc acatactacg cagactccgt gaagggccgc ttcaccgtct ccagagacaa
      361 ctcaaagaac acgctctccc tccaagtgaa cagcctgaga cctgaggaca cggccgtgta
      421 ttactgtgcg aaaggaggta gcagctcttt ctactggtac ttcgatatcc ggggccctgg
      481 caccccagtc accatctcct cagcc
//
LOCUS       KCXD01000520             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6507:10710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000520
VERSION     KCXD01000520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6507:10710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..336
     V_segment       1..266
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59002.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       270..277
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           72 a           99 c           88 g           79 t
ORIGIN      
        1 gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt gactccatca
       61 gcagtagcta ctggaactgg atccgtcagc ccccagggaa gggactggag tggattgggt
      121 atatctctgg ttcttatggg agcaccagct acaacccctc cctcaagagt cgagtcacca
      181 tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg accgccgcgg
      241 acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac cactttgact
      301 tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000521             414 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12907:5810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000521
VERSION     KCXD01000521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 414)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 414)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12907:5810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    46..412
                     /note="immunoglobulin heavy chain variable region"
     V_region        46..412
     V_segment       46..339
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <331..>381
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59003.1"
                     /translation="CARGLPTVFGVVITDVW"
     D_segment       360..371
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       373..412
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        413..>414
                     /gene="IGHG"
BASE COUNT           78 a          119 c          122 g           95 t
ORIGIN      
        1 acatggggct cactgtgggt ctctctgttc acaggggtcc tgtcccaggt gcagctgcag
       61 gagtcgggcc caggactggt gaagccctcg gagaccctgt ccctcacctg cactgtctct
      121 ggtgactcct tcagcggtta ctactggagc tggatccgcc agcccccagg gaaggggctg
      181 gagtggattg ggcatatcag tgttagtctt gggaagaccg actacaaccc gtccctcaag
      241 agtcgagtca ccatttcaac agacacgtcc aagaaccagt tctccctgaa ggtgaactct
      301 gtgaccgccg cggacacggc cgtatattac tgtgcgagag gacttcctac agtttttgga
      361 gtggttatta cggatgtctg gggcccggga gtcctggtca tcgtctcctc agcc
//
LOCUS       KCXD01000522             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19844:4379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000522
VERSION     KCXD01000522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19844:4379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..324
     V_segment       8..249
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <243..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59004.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       263..269
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       273..324
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        325..>326
                     /gene="IGHG"
BASE COUNT           85 a           83 c           88 g           70 t
ORIGIN      
        1 acatgggagt gaaggtctcc tgcaaggttt ccggatacat cttaaccgaa ttatccatac
       61 actgggtgcg acaggcccct ggaaaagggc ttgagtggat gggaagtgtt gatcctcaat
      121 atggtgaaat gatagacgca gagaaattcc agggcagagt caccatgacc gaggacacgt
      181 ctacagacac agcctacatg gagctgagta gtctgagatc tgaggacacg gccgtgtatt
      241 actgtgcgac atcatccagc ggcacctggc tatactggta cttcgatatc tggggccctg
      301 gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01000523             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11448:12047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000523
VERSION     KCXD01000523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11448:12047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..494
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59005.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       414..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          110 a          135 c          144 g          111 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg ctacaccttc agcatctctt ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttgg gtggatagga gggatcatcc ctcttgttgg tatgacaaac tacgaacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc ttcatggaaa
      361 tgagcagcct gagatttgag gacacggccg tctactattg tgcgacaggg gtatattacc
      421 aggatgaata cggttatttt tatgtcggcg gtgactttga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01000524             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15664:5410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000524
VERSION     KCXD01000524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15664:5410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59006.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       431..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          124 c          158 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcccg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagaacata ctacgcagac tccgtgaggg gccgattcac catctccaga gacaattcag
      361 agaacacgct ctccctgcaa atgaacagcc tgacagctga ggacacggcc gtgtattact
      421 gtgcgaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000525             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:17553:16194
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000525
VERSION     KCXD01000525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:17553:16194"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59007.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       440..452
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          110 c          155 g          119 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gtaacggcat
      241 gcactgggtc cgccaggttc cagggaaggg gctggagtgg gtggcagtga catcgtttga
      301 tgaaagtaag aaatactacg cagactctgt gaaggaccga ttcaccgtct ccagagacaa
      361 ttccaagaac atggtatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttactgtgtg agagactctt atggaagtgg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000526             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22686:14185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000526
VERSION     KCXD01000526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22686:14185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..496
     V_segment       139..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59008.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       438..445
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..496
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          118 a          116 c          148 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagaccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtccaactg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagcaa ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtacgat
      301 gaaagtaaga aatactacgc agactctctg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctttatct tcaaatgaac aacctgaaaa tggaggacac ggccgtttat
      421 tactgtgcga ggaggccctg gaatgcagat gcttttgatt tctggggcca aggactcagg
      481 gtcaccgtct cttcagcc
//
LOCUS       KCXD01000527             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5496:12226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000527
VERSION     KCXD01000527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5496:12226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59009.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       405..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           92 a          140 c          129 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcccgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatca ccagtagctt ctggaactgg tgccgccagc ccccagggaa gggactggag
      241 tggattggat atatctctgg tgctactggg agtaccagct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gaactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgcggatga ttacggttat
      421 tattaccttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000528             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19195:4317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000528
VERSION     KCXD01000528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19195:4317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59010.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          115 c          147 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagag gagaaatttg gctacagttt tgacttctgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000529             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9480:19168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000529
VERSION     KCXD01000529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9480:19168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59011.1"
                     /translation="CARGRYNWKGVLVDFW"
     D_segment       399..411
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..464
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          136 c          134 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg tgtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccgtcagc aataactact ggacttggat ccgccagccc ccagggaagg ggctggaatg
      241 gattggccgt atctatggtc gtattgggaa caccgactac aacccctccc tcaacagtcg
      301 agtcgccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctca gctctgtgac
      361 ggccgcggac acggccgttt attactgtgc gagaggccgg tataactgga aaggtgtctt
      421 agtggatttc tggggccaag ggctcagggt cgccgtctct tcagcc
//
LOCUS       KCXD01000530             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:26360:7143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000530
VERSION     KCXD01000530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:26360:7143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59012.1"
                     /translation="CAAADIGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          141 c          128 g          100 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat gcctgcactg ggttcgacag
      241 gcccctggaa aagggcttga gtggatggga agttttaatc ctatatatgg tgaaatttta
      301 caaacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatattggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01000531             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15064:6927
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000531
VERSION     KCXD01000531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15064:6927"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..433
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59013.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       447..451
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          104 a          128 c          152 g          114 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca caccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccattg tgaggtgcag ctggtggaat ctgggggcgg cttggcaaag
      181 cctggggggt ccctaagact ctcctgtgca gcatccggat tcaccttcag tgaccactgc
      241 atgcactggg tccgccaggc ttcagggaag gggctggagt gggtctcagg tattacttat
      301 actggtgtta ccacttggga cgcagactcc gtgaggggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcacatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg tgacaggaag gcgacacgtg gaccttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000532             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21822:13193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000532
VERSION     KCXD01000532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21822:13193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59014.1"
                     /translation="CASNLRGNTFSYWRSFDFW"
     D_segment       450..456
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          109 a          133 c          157 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggtcc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggtggtgg tagtaaatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacagcct gacacctgag gacacggccg
      421 tttattactg tgcgtcgaac ctacgtggaa acaccttcag ttactggcgg tcctttgact
      481 tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000533             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12877:6023
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000533
VERSION     KCXD01000533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12877:6023"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59015.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       423..430
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          142 c          150 g           98 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccgctct
      121 gaggtccaac tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggaga caccttcacc gacttatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgaccctg caaatggtga aataatacac
      301 gcagatagtt tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcggcctgcg atctgaggac acggccgttt attactgtgc gagagggggc
      421 ttcggtagca gtgtctggtc caatctcgtc tatggtttgg attcctgggg ccaaggggtc
      481 gccgtcaccg tctcctcagc c
//
LOCUS       KCXD01000534             374 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17955:8101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000534
VERSION     KCXD01000534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 374)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 374)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17955:8101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..372
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..372
     V_segment       5..299
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>341
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59016.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       310..324
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       331..372
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        373..>374
                     /gene="IGHG"
BASE COUNT           80 a           94 c          111 g           89 t
ORIGIN      
        1 acatggggca gttggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
       61 tctcctgtgc agcctctgga ttcaccttca gtgactactg gatgtactgg gttcgccaga
      121 cacctgagca gggtctggaa tggatctcag ctattgatag tgctggtact agtaccacat
      181 actatgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc aaaaacacac
      241 tgtatcttca gatggacagc ctgagaactg aggacacggc tgtctattac tgtgcgagag
      301 ttccgggcct agtggtattt actggttcgc ttgactactg gggccaggga gtcctggtca
      361 ccgtctcctc agcc
//
LOCUS       KCXD01000535             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24229:12306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000535
VERSION     KCXD01000535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24229:12306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..493
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59017.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       432..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          115 a          142 c          145 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggacacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggctgg gaggtgttga tcttgtatat gatgaaataa
      301 tacacgcaga gaagttccaa ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcggcgg
      421 gccttggggg atatttactg ctcactgaat acctcgagtt ctggggccag ggcgccctgg
      481 tcaccgtctc ctccgcc
//
LOCUS       KCXD01000536             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13471:12804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000536
VERSION     KCXD01000536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13471:12804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59018.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          123 a          141 c          133 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagattcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000537             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:24367:10743
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000537
VERSION     KCXD01000537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:24367:10743"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59019.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          138 c          127 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaattgg gtccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatgag agcaccagct acaacccctc cctcacgggt
      301 cgagtcacca tttcaactga cacgtccaag aaccagtttt ccctgaggct gagttctatg
      361 accgccgcgg acaccgccgt atattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000538             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19748:13450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000538
VERSION     KCXD01000538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19748:13450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59020.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          135 c          133 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaac agtggttatg gctggaactg ggtccgccag cccccaggga aggggctgga
      241 gtggattggg tgtctctatg atagtagtgg gaacacgtac tacaacccct ccctcaagag
      301 tcgcgtcacc atttcaaaag acacgtccaa aaaccagttc tccctgaacc tgaggtctat
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000539             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18974:14231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000539
VERSION     KCXD01000539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18974:14231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59021.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       418..425
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          139 c          128 g          109 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcttgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggcctggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcaatagc tactggaact ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtatatctct ggtgcttatg ggagtaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaact gacacgtcca agaaccagtt ttccctgagg ctggcttctg
      361 tgaccgccgc ggacaccgcc gtttattact gtgtgagata tgaggacgaa tccataaact
      421 accactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000540             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7002:17329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000540
VERSION     KCXD01000540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7002:17329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59022.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       434..438
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          123 c          159 g          114 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat
      241 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      301 tggggagagc acatactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagtggtgg gtggtgccgc aggatacttc gacttctggg gccagggcgc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000541             436 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15147:13387
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000541
VERSION     KCXD01000541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15147:13387"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..433
     V_segment       153..371
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <365..>403
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59023.1"
                     /translation="CATADYGNSLDFW"
     D_segment       377..388
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..433
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>436
                     /gene="IGHG"
BASE COUNT          104 a          104 c          124 g          104 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggagtccag tgtgaggtgc agctggattc accttcagta gctttggcat
      181 gcactgggtc cgccaggctc cagggaaggg gctggaatgg gtggcagtta tatcgtctga
      241 tggaagtatg agattctacg cagactctat gaaggaccga ttctccatct ccagagacaa
      301 ttccaagaac atggtatatc ttcaactgaa caacctgaaa ttggaggaca ctgccgttta
      361 ttactgtgcg acagccgact acggtaacag ccttgacttc tggggccagg gagtcctggt
      421 caccgtctcc tcaacc
//
LOCUS       KCXD01000542             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5279:13985
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000542
VERSION     KCXD01000542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5279:13985"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59024.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          135 c          130 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaattggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggta gttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgagtcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000543             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14923:7560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000543
VERSION     KCXD01000543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14923:7560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..496
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59025.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>499
                     /gene="IGHG"
BASE COUNT          117 a          115 c          149 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag ggttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca atacctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatgaaact aaaaaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atcttcaaat ggacaacctg aaattggagg actcggccgt
      421 gtattactgt gtgagagacg catttggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01000544             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21422:18686
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000544
VERSION     KCXD01000544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21422:18686"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59026.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          143 c          136 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccattc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggtg aaatgataca
      301 cacagaacag ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cgagtggccc
      421 tagcggcagc tggaacgact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000545             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11839:7371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000545
VERSION     KCXD01000545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11839:7371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59027.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          102 a          142 c          128 g          107 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tatagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctcagccga caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000546             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18427:9638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000546
VERSION     KCXD01000546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18427:9638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    147..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        147..519
     V_segment       147..439
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59028.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       454..468
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..519
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          115 a          127 c          148 g          131 t
ORIGIN      
        1 acatggggga gctctgggag aggagaccca gccttgggat ttccagctgt ctccacttgg
       61 tgatcagcac tgaacacagg agactcgcca tggagtttgt actgagctgg gttttccttg
      121 ttgctatatt aaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg
      181 tccagcctgg cgggtccctg agactctcct gtgcagcctc tggattcacc ttcagtgact
      241 atgccctgag ctgggtccgc caggcttctg ggaaaggact ggagtggatt ggctatatta
      301 gaagccaata taacaatttc gcgacagaat acgccccatc ggtgaaaggc agattcacca
      361 tctccagaga tgattcacag aacacgctat ttctgcaaat gagtagcctg aaaaccgagg
      421 acacggccgt gtattactgc accacccatt ttggtggtaa ttattacttg gactactttg
      481 tctactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000547             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13599:5849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000547
VERSION     KCXD01000547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13599:5849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59029.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          114 c          151 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacattc tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000548             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:25085:13673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000548
VERSION     KCXD01000548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:25085:13673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..356
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59030.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       283..289
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       312..356
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           83 a           81 c          109 g           85 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcagc ttcagtggct ttggcataca ctgggtccgc caggctcctg ggaaggggct
      121 ggagtgggtg tcacttatat cgtatgatgg aagtaagaaa tactacgcag actctgtgaa
      181 ggaccgattc accttgtcca gagacaattc caagaacatg gtatatcttc acatgaacaa
      241 cctgaaattg gaggacacgg ccgtgtattt ctgtgcgaga gttagtgggc atacagaggg
      301 gacagttgaa aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000549             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18473:13731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000549
VERSION     KCXD01000549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18473:13731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..516
     V_segment       153..444
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59031.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       461..471
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          100 a          156 c          139 g          123 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg ccgaggtgca gctggtgcag tctggagcag
      181 aggtgaaaag gcccggggaa tctctgagga tctcctgtaa gacttctgga tacagtttta
      241 ccaattactg gatcagttgg gtgcgccaga tgcccgggaa aggcctggag tggatgggaa
      301 tgatctatcc tagtgattct gatcccagat acagcccgtc cttccaaggc caggtcacca
      361 tctcagccga caggtccatc agcaccgcct acctggagtg gggcagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagagctg gacgctacac ctacagttac ccctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000550             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23460:7810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000550
VERSION     KCXD01000550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23460:7810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59032.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          140 c          128 g           94 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcaccccac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagttg gtacagtctg gggttgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccagtct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatggtaaag tagactacac
      301 acagaagttc caagacagag tcaccatcac cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgacttct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000551             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14510:10428
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000551
VERSION     KCXD01000551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14510:10428"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59033.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       438..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          108 c          157 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggctgg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc aacggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtgata tcgtttgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acttgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agactcttat ggaagtggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000552             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4892:17508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000552
VERSION     KCXD01000552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4892:17508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59034.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          117 c          154 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtagcctcg
      241 gcatgcactg ggtccgccgg gctccaggga aggggctgga gtgggtggca gttatctcgt
      301 ctgatggaag tcagaaatat tatgcagact ctatgaagga ccgattcacc atctccagag
      361 acaatgccaa gaacatgctg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000553             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12917:13421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000553
VERSION     KCXD01000553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12917:13421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..434
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59035.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       448..453
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          102 a          125 c          156 g          123 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc cagaattccc aggtgtttct gttcggcgat
       61 cagcactaaa cacagaacaa accatggagt ttgtgctgag ctgggttttc cttgttgctc
      121 ttttgaaagg tgtccagtgt gaggtgcagt tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgcgcag cctctggatt cagcttcagt ttctactaca
      241 tgagctgggt ccgccagcct ccagggaagg gtctggagtg gatctcaggt attaacgctg
      301 gtggggatgg cacatactct gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaagaa cacactgcat cttcaaatgg acagcctgag aactgaggac acggctgtct
      421 atttctgtgt gagagatcga cgtgttcagt cgttatcctg gttcgatgtc tggggcccgg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000554             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22201:11845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000554
VERSION     KCXD01000554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22201:11845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59036.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          114 c          149 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gcacctttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcata
      301 tgatgaaact aagaaatact acacagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat attttcaaat gaacaacctg aaattggagg acacggccat
      421 atattactgt gcgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000555             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25278:13346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000555
VERSION     KCXD01000555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25278:13346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..330
     V_segment       7..257
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>300
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59037.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       264..277
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..330
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>333
                     /gene="IGHG"
BASE COUNT           77 a           90 c           92 g           74 t
ORIGIN      
        1 acatgggggg cctcagtgaa ggtctcctgc aaggtttccg gatacacctt cagcgattta
       61 tccatacact ggatacgaca ggcccctgga aaagggcttc agtggatggg aagtgttgat
      121 cctgcttttg gtgaaatgat aaacgcagag aagttccagg gcagagtcac catgaccgag
      181 gacacgtctt cagacacagc cttcatggaa ttgagcagcc tgaaatctga cgacacggcc
      241 gtgtatttct gtgcgagtgg ccctagcggc acctggatcg actggtcctt cgatgtctgg
      301 ggccctggca ccccaatcac cgtctcctca acc
//
LOCUS       KCXD01000556             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10727:7400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000556
VERSION     KCXD01000556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10727:7400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59038.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       444..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          115 a          109 c          154 g          120 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgca gcctctggat tcagtttcag taattatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggaat gggtggcagt tatgtcatct
      301 gatggaacta agaaattcta cgcagactct gtgaaggtcc gattcaccat ctccagagac
      361 aattccaaga acatggtata tcttcaaatg aacagcctga aatcggagga cacggccgta
      421 tattattgtg ggagagatga taatggggtg attatcgact actggggcca gggagtcctg
      481 gtcaccgtca cctcagcc
//
LOCUS       KCXD01000557             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17078:17058
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000557
VERSION     KCXD01000557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17078:17058"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59039.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          103 a          114 c          162 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcacagcctg
      181 gggggtccct gagactctcc tgttcagcct ctgggttcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctccggtatt aatagtggtg
      301 gggatactac atactacgta gactccgtga agggccgatt caccatgtcc agagacaatt
      361 caaagaacac tctctccctg caaatgaaca gcctgagagc ggaggacacg gccgtgtatt
      421 attgtgtgca aggggaaatt tttggagtgg gtttggattt ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000558             425 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19056:18187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000558
VERSION     KCXD01000558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19056:18187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..423
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..423
     V_segment       63..353
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <345..>392
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59040.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       356..371
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       375..423
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        424..>425
                     /gene="IGHG"
BASE COUNT           85 a          104 c          135 g          101 t
ORIGIN      
        1 acatggggga gtctgggctg agctgggttt tccttgttgc tattttaaga ggtgtccagt
       61 gtgaggtgca ggtggtggag tctgggggcg gcttggcaaa gcctggggga tccctgagac
      121 tctcctgtgc agcctctgga ttcaccttca gcacctatgc tatgcactgg gtccgccagg
      181 ctccaggaaa ggggctggag tgggtctcag ccattagtgt tggtggtagt acatactacg
      241 cagactccgt gaggggccga ttcaccatct ccagagacaa ctcagagaac acgctctccc
      301 tgcaaatgaa cagcctgaga gctgaggaca cggccgtata ttactgtgcg aaaggggata
      361 cagctacagt ttattacggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct
      421 cagcc
//
LOCUS       KCXD01000559             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:21700:17189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000559
VERSION     KCXD01000559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:21700:17189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59041.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          140 c          153 g           98 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctgcaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 ggggttcggt agcagtgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01000560             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16617:3292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000560
VERSION     KCXD01000560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16617:3292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59042.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       448..453
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          119 c          162 g          114 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggca
      181 aagccggggg ggtccctaag actctcctgt gcagcctctg gattcacctt cagtaggcac
      241 tggatgaact gggtccgcca ggctccagga aaggggctgg agtgggtctc aactattaat
      301 agtggtgggg acaacacata ttacgcagac tccgtgaagg gccgacttac catttccaga
      361 gacaactcaa agaacacgct cctcctgcaa atgaacagcc tgagagtgga ggacacggcc
      421 gtgtattact gtgttcaagg ggaaattttt ggagtgggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000561             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:17366:11922
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000561
VERSION     KCXD01000561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:17366:11922"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59043.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          111 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaggat gctatttctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000562             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12611:6584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000562
VERSION     KCXD01000562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12611:6584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..483
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59044.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>487
                     /gene="IGHG"
BASE COUNT          117 a          141 c          130 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggct acagcttcgc cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg ttttgctagt atatatggtc aaataataca
      301 tacagagaga ttccagggca gagtcaccat gacagcggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctccgcc
//
LOCUS       KCXD01000563             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12297:10864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000563
VERSION     KCXD01000563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12297:10864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59045.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       407..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          134 c          136 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag gtgcaggagt
      121 cgggcccagg actggtgaag cctccggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctctatcag cagtagttac tgcagctgga tccgccagac cccagggaag ggactggagt
      241 ggattggata tatctatggg agtgatagta gtaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagtgctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagttcggg tatagaagtg gttgcctaca
      421 gcattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000564             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7709:14350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000564
VERSION     KCXD01000564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7709:14350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59046.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       424..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          119 a          139 c          141 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 agtctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg acctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccgttcat tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtattga tcctctatat ggtgaaatga
      301 tacacacaga gaagttccag ggcagagtca ccatgaccga ggacacgtct acagatacag
      361 cctacatgga gctgaggagc ctgagatctg acgacacggc cgtgtattac tgtgcgaggt
      421 cggatagcgg cagttggaac ggctggtacc tcgatctctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01000565             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:7085:13022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000565
VERSION     KCXD01000565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:7085:13022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59047.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          120 a          111 c          155 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtggccag tgtgaggtga agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgcg cagcttccgg attcaccttc agtttctatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcga
      301 atgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atcaccagag
      361 acaattccaa gaacatagta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000566             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22188:12128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000566
VERSION     KCXD01000566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22188:12128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59048.1"
                     /translation="CATGRIGSSGWSNLFTGLESW"
     D_segment       425..438
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          146 c          143 g           96 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccacct ggtgcagtct ggggctgagg tgaagcagcc tggggcctca gtgaaggtct
      181 cctgtaaggt ttccggatac accgtcaccg aattatccat gcactgggtg cgacaggccc
      241 ctgggaaagg gcttgagtgg atgggagttg ttgatcctgt caatggtgaa gaaattcacg
      301 cagagaaatt ccagggcaga gtcaccttga ccgaggacac gtccacagac acagcctaca
      361 tggacttgac cagtctcaga tctgaggaca cggccatcta ttactgtgcg acagggagga
      421 tcggtagcag cggctggtcc aacctcttca ccggtttgga atcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000567             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15472:20994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000567
VERSION     KCXD01000567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15472:20994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..442
     V_segment       85..378
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59049.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       385..391
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT          102 a           97 c          132 g          113 t
ORIGIN      
        1 acatgggcag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctattttaa gaggtgtcca gtgtgaggta caattggtgg agtctggagg aggtttggtt
      121 cagcctgggg ggtccctgag actctcctgt gaagcttctg gattcacctt cagtaactat
      181 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      241 tatgatgtaa gtaggaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      301 gacaattcta agaacatgct atatcttcaa atgagcaacc tgaaattgga ggacacggcc
      361 gtgtatttct gtgcgagacg cccttggaac gctgactact ttgactactg gggccaggga
      421 gtcctggtca ccgtctcgtc agcc
//
LOCUS       KCXD01000568             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15120:9840
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000568
VERSION     KCXD01000568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15120:9840"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59050.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          115 a          142 c          129 g           92 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctacactggg tgcgacaggc
      241 tcctgggaaa ggacttgagt ggatgggagg tgttcatcct gaatatggaa aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000569             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17604:8903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000569
VERSION     KCXD01000569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17604:8903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59051.1"
                     /translation="CVSNLRGNTYTYWRSFDFW"
     D_segment       460..467
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          112 a          132 c          158 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtc
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat
      241 ggcatgacct gggtccgcca ggctccaggg aaggggctgg agtgggtctc atacattagt
      301 attggtggta gtaatagaaa ctacgcagac tccgtgaagg gccgattcac catctccaga
      361 gacaactcag agaaaacgct ctccctgcaa atgaacagcc tgagacctga ggacacggcc
      421 gtgtattact gtgtgtcgaa cctacgtgga aacacctaca cttactggcg gtcctttgac
      481 ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000570             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:22979:3066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000570
VERSION     KCXD01000570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:22979:3066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59052.1"
                     /translation="CARDAFGSGLDYW"
     D_segment       442..448
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          116 c          149 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctctct
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttatt tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgctt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca accttaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgctttc ggcagcgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000571             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:4894:6813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000571
VERSION     KCXD01000571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:4894:6813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59053.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       440..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          114 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc tattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgacgtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg caggttctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatgtcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaccct gaaattggag gacacggccg
      421 tgtattactg tgcgagggat gtctttggcg ggggacttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000572             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22582:4946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000572
VERSION     KCXD01000572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22582:4946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59054.1"
                     /translation="CAAGLGGYLLLTEYFHFW"
     D_segment       421..426
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          112 a          141 c          139 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggttca gtctggggct gaagtgaaga ggcctggggc ctcactgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaatttt ccattcactg ggtgcgacag
      241 gcccctggaa tagggcttga gtggttggga agtgttgatt atcaatatga tgaaataatt
      301 cacgcagaga aattccagga cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagcagcct gggatctgag gacacggccg tgtattactg tgcggcgggc
      421 ctgggggggt atctattgct tactgaatat ttccacttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01000573             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16429:18841
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000573
VERSION     KCXD01000573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16429:18841"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59055.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000574             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17239:13672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000574
VERSION     KCXD01000574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17239:13672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59056.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          149 c          131 g           94 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacat
      301 tccagggcag agtcttcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac gcggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000575             353 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6009:12110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000575
VERSION     KCXD01000575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 353)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 353)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6009:12110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..351
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..351
     V_segment       8..290
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59057.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       294..306
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       310..351
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        352..>353
                     /gene="IGHG"
BASE COUNT           83 a           85 c          103 g           82 t
ORIGIN      
        1 acatgggggt ggagtctggg ggaggcttgg ttcagcctgg ggggtccctg agactctcct
       61 gtgcagcctc tggattcacc ttcagaacct ttggcatgca ttgggtccgc caggctccag
      121 ggaagggact ggagtgggtg gcagttatat cgtctgatgg aggttacaaa tactacgcag
      181 actctaagaa ggaccgattc accatctcca gagacaattc caagaacatc ctatatcttc
      241 aactgaacaa cctgaaattg gaggacacgg ccgtgtatta ttgtgcgaga ggggaataca
      301 gtaactctat tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000576             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18307:19053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000576
VERSION     KCXD01000576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18307:19053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59058.1"
                     /translation="CARDDSGTGFDYW"
     D_segment       443..451
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          112 c          156 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctatcttaa gaggtgtcca gtgtgaagtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcct ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa ttaataagta ctacgcagac tctgtgaagg accgatacac catctccaga
      361 gacaattcga ggaacatgct gtatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattatt gtgcgagaga tgatagtggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000577             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18692:16360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000577
VERSION     KCXD01000577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18692:16360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59059.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          115 a          144 c          130 g           92 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caagcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtaga
      301 ctacacacag aagttccgag acagagtcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01000578             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9512:4413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000578
VERSION     KCXD01000578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9512:4413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..515
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59060.1"
                     /translation="CVRDIPYYNFWSGYDSGLDAW"
     D_segment       439..463
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          110 a          123 c          157 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc cggattcatc ttcagtgacc actacatgga
      241 ctgggtccgc caggctccag ggaaggggct ggaatgggcc tcacgtgtta ctaatgatgg
      301 tggtagcaca tggtacgcag actccgtgaa ggacagattc accatctcca gagagaacgc
      361 cgagaacacc ctttatcttc aaatgaaaag cctgagagct gaggacacgg ctgtctattt
      421 ttgtgtgaga gatattccgt attacaattt ttggagtggt tatgactccg gtttggatgc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000579             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20772:13036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000579
VERSION     KCXD01000579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20772:13036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59061.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       441..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          104 a          125 c          155 g          114 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca caccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccattg tgaggtgcag ctggtggaat ctgggggcgg cttggcaaag
      181 cctggggggt ccctaagact ctcctgtgca gcatccggat tcaccttcag tgaccactgc
      241 atgcactggg tccgccaggc ttcagggaag gggctggagt gggtctcagg tattacttat
      301 gctggtgtta ccacatggta cgcagactcc gtgaggggca gattcaccat atccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg tgggaggaag gcggcacgtg gaccttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000580             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20479:10094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000580
VERSION     KCXD01000580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20479:10094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59062.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          103 a          126 c          155 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttac tacttcatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt accagtggtg
      301 ggactaacac atactctgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaccac actgtatctt cacatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgtaag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000581             301 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7661:14477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000581
VERSION     KCXD01000581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 301)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 301)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7661:14477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..299
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..299
     V_segment       8..224
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>268
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59063.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       238..244
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..299
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        300..>301
                     /gene="IGHG"
BASE COUNT           76 a           82 c           79 g           64 t
ORIGIN      
        1 acatggggga tacaccttca ccgaactgtc catccactgg gtgcgacagg cccctggaaa
       61 aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa acgcagaaaa
      121 attccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct acatggagct
      181 gatcagtctg agatctgaag acacggccct gtattactgt gcgacatcac ccagcggcac
      241 ctggctattt tggtacttcg atttctgggg ccctggcacc ccaatcacca tctcctcagc
      301 c
//
LOCUS       KCXD01000582             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18245:7572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000582
VERSION     KCXD01000582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18245:7572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59064.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          120 a          140 c          135 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgagttatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000583             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24447:10756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000583
VERSION     KCXD01000583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24447:10756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59065.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          125 c          158 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga gctgcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcactc aacacagaac ataccatgga gtatgtgctg agttgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000584             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14043:14689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000584
VERSION     KCXD01000584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14043:14689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59066.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       446..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          119 c          148 g          119 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcccagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaagtgcaa ctggtggagt ctggaggagg cttggttcgg
      181 cctggggggt ccctgagact ctcctgttca gcctctggat tcaccttcag taattttggc
      241 atccactggg tccgccaggc tccagggaag ggcctggagt gggtggcagt tacatcgtct
      301 gatgaaagta agaaatacta tgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga atatgctata tcttcaaatg aacaacctga agttggagga cacggccgtc
      421 tattactgtg cgagagacgc atatggcagc ggctgtgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000585             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21205:12613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000585
VERSION     KCXD01000585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21205:12613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59067.1"
                     /translation="CAREEGEASGYRFGYW"
     D_segment       450..458
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          118 a          114 c          158 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcga
      121 ttttaagagg tgtccaatgt gaggtgcgcc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtacag cctctggatt caccttcagt agctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcatatg
      301 atggaagcaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catactatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgtgc gagagaagag ggggaggcta gtgggtaccg atttggctac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000586             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20046:9211
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000586
VERSION     KCXD01000586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20046:9211"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59068.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          146 c          142 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01000587             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17372:18120
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000587
VERSION     KCXD01000587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17372:18120"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..347
     V_segment       4..277
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59069.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       295..299
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       303..347
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>349
                     /gene="IGHG"
BASE COUNT           74 a           91 c          106 g           78 t
ORIGIN      
        1 acatgggggc ggcttggcaa agcctggggg gtccctgaga ctctcctgcg cagcctctgg
       61 attcagcttc agttactact acatgagctg ggtccgccag gctccaggga aggggctgga
      121 gtggatctca ggtcttgcca gtggtgggga tagcacatac tatgcagact ccgtgaaggg
      181 cagattcacc atctccagag agaacgccaa gaacacactg catcttcaaa tggacagcct
      241 gagagttgaa gacacggctg tctattactg tgtgagagat cgacgtgttc agtcattatc
      301 ctggttcgat gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000588             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8683:7525
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000588
VERSION     KCXD01000588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8683:7525"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59070.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          111 c          157 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga ttctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg cgcgagagac gattttggca gcggcttagg gtactggggc cagggagccc
      481 tggtgaccgt ctcttcagcc
//
LOCUS       KCXD01000589             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19890:17070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000589
VERSION     KCXD01000589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19890:17070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..286
     V_segment       7..211
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <205..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59071.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       229..237
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..286
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           70 a           79 c           83 g           56 t
ORIGIN      
        1 acatggggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc ccctggaaaa
       61 gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt ccagggcaga
      121 gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag cagcctgaca
      181 tctgaggaca cggccgtgta ttactgcgcg attggcccta gtggcagatg gaacgactgg
      241 tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000590             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18304:7441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000590
VERSION     KCXD01000590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18304:7441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59072.1"
                     /translation="CARSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          148 c          136 g           89 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccgctc
      121 tgaggtccag ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattctcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gcatatggtg aaatgacaca
      301 cgcagaaaac ttccagggca gactcaccat gaccgaggac acgtcaacag acacggccta
      361 catggagctg agcagcctga gatctgaaga cacggccgtg tattactgtg cgagatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 cgcctcagcc
//
LOCUS       KCXD01000591             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9368:10178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000591
VERSION     KCXD01000591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9368:10178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59073.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          114 c          158 g          114 t
ORIGIN      
        1 acatgggggg gaaaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gttcagctgg tggagtctgg aggaggcttg ggtcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaag tcgcatgatg
      301 gaactaagaa atactacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat gctatatctt gaaatgaaca gcctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000592             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17474:8432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000592
VERSION     KCXD01000592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17474:8432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59074.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       439..444
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          117 c          147 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca ggctcccggg aagggtctgg agtgggtagc agttatctcc
      301 catgatgaga ataatatata ttacgcagac tccgtgaagg accgattcac catctccaga
      361 gacaattcca agaacaacgt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgttttact gtgtgagaga tacattcggt tcagggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000593             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14557:16971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000593
VERSION     KCXD01000593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14557:16971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59075.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          114 c          155 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttcg gaacctatgg
      241 cattcactgg gtccgccagg ctccagggaa gggcctggag tgggtgacgg ttatatcgaa
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcagca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacgtg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cgtttggtag cgggcttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000594             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17273:14618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000594
VERSION     KCXD01000594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17273:14618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59076.1"
                     /translation="CARGDIGNGVDYW"
     D_segment       440..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          154 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatgttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 atgatgaaat tacgaaatac tacgcagact ctgcgaagga ccgattcacc atctccagag
      361 acaattccaa gaatatggta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtatttctg tgccagaggg gatattggta atggcgtcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01000595             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15389:15805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000595
VERSION     KCXD01000595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15389:15805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59077.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          109 a          145 c          135 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaagt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caggatttcc ggatacacct tcaccgaatt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctgtat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacttggaac
      361 tgagcggcct gacttctgag gacacggtcg tgtattactg tgcgactggc cctaccggca
      421 cctggaacgc ctggtacctc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01000596             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13108:14205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000596
VERSION     KCXD01000596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13108:14205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..484
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59078.1"
                     /translation="CAREFSPYDYVWSDFYSYYFDYL"
     D_segment       409..415
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           94 a          145 c          134 g          113 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccttcagcg gttactactg gagctggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggcata tcagtgggag tagtgggagc accgactaca acccctccca caaaagtcga
      301 gtcatcattt caacagacac gtccaagagc cacttctccc tgaaactgag ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagagtttt ccccctacga ctatgtttgg
      421 agtgattttt actcttacta ctttgactac ttgggccagg gactcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000597             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19129:12902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000597
VERSION     KCXD01000597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19129:12902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59079.1"
                     /translation="CSSGRRQLDFDYW"
     D_segment       403..408
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          134 c          132 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctacagt tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcaac atttactact ggaattggat ccgcctggcc ccagggaagg gactggactg
      241 gattggacat atctatggta gcggtgggag caccatctac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagttctcc ctgaacctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgttc gagcggtcgg cgacagttgg actttgacta
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000598             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14835:11143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000598
VERSION     KCXD01000598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14835:11143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59080.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          135 c          130 g          109 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggacaggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaattg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acatgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000599             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15521:13925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000599
VERSION     KCXD01000599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15521:13925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..454
     V_segment       94..385
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <379..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59081.1"
                     /translation="CAIQGLVVVAGFDYW"
     D_segment       400..407
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           86 a          136 c          134 g          100 t
ORIGIN      
        1 acatggggga gagtcacaga catcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtac agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcgcttact actggagctg gatccgccag gccccaggga agggactgga gtggattggg
      241 tatatctatg gtggtagtgg gagcaccacc tacaacccgt ccctcaagag tcgagtcacc
      301 ttttcaatag acacgtccaa gaaccagttc tccctgaagc tgacctctgt gaccgccgcg
      361 gacacggccg tctattactg tgcgatccaa gggctcgttg tggttgcggg ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000600             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16151:9930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000600
VERSION     KCXD01000600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16151:9930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59082.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          118 a          113 c          147 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caattggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag gctctcctgt gcagcctctg gattcacctt cagtaattat
      241 ggcttccact gggtccgcca ggctccagtg aaggggctgg agtgggttgc agttatatcg
      301 tatgatgaaa atgtgaaatt ctacgcagac tctgtaaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtacgagagg ggaatacagt aactctattg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000601             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10216:14052
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000601
VERSION     KCXD01000601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10216:14052"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59083.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          111 c          156 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagtctctg gattcgcctt cagtaacttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgacatcg
      301 tatgatggaa gttggaagta ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagagg ggaatatagt aactctattg actattgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000602             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12326:8763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000602
VERSION     KCXD01000602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12326:8763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59084.1"
                     /translation="CARDEGEVSGYRFGYW"
     D_segment       453..460
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          113 a          114 c          161 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaaa ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaacatgcta taccttcaaa tgaaccacct gagattggag gacacggcca
      421 tgtattactg tgcgagggat gagggggagg ttagtgggta tcgatttggc tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000603             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17322:5832
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000603
VERSION     KCXD01000603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17322:5832"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59085.1"
                     /translation="CTTSSWNDDFW"
     D_segment       448..459
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          121 a          121 c          145 g          114 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattt ccagctgtct ccacttggtg
       61 atcagcactg aacacaggag actcgccatg gagtgtgtac tgagctgggt tttccttgtt
      121 gctataataa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag aatctcctgt gcagcctctg gattcctctt cagtgactat
      241 gccatgaact gggtccgcca ggcttctggg aaaggactgg agtggattgg ctatattaga
      301 aacaagtata acaattacgc gacagaatac gccgcatcgg tgaaaggcag attcaccatc
      361 tccagagatg attcaaagaa cacggtatat ctgcaaatga gtagcctgaa aaccgaggac
      421 acggccatat attactgcac cacatccagc tggaacgacg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000604             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12255:8117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000604
VERSION     KCXD01000604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12255:8117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59086.1"
                     /translation="CAKGETAAVYYGLDSW"
     D_segment       440..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          134 c          151 g          111 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca gctggtcgag tccgggggcg gcttggcgaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctacgc
      241 cattcactgg gtccgccagg ctccagggaa gggactggag tgggtctcag ccattagtag
      301 tggtggcagc acattctacg cagcctccgt gaagggccga ttcaccatct ccagagacaa
      361 ttcaaagaac acgctctccc tacaaatgaa cagcctaaca actgaggaca cggccatgta
      421 ttactgtgcg aaaggagaaa cagctgcagt ttactacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01000605             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16684:4471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000605
VERSION     KCXD01000605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16684:4471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59087.1"
                     /translation="CARGTGAILVYFDHW"
     D_segment       439..445
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          125 c          152 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgagatacaa ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcctcag atactactat
      241 atgacctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 gatgggagta gcacatacta tgcagactcc gtgaaggaca gattcaccat ctccagagac
      361 aacgccaaga acacactgtc tcttcaaatg gacagcctga cagctgagga cacggctgtc
      421 tattattgtg cgagggggac tggggcgatt cttgtgtact ttgaccactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000606             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10244:18511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000606
VERSION     KCXD01000606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10244:18511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59088.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       263..275
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           81 a           76 c           88 g           77 t
ORIGIN      
        1 acatgggggg gggaccctga ggctctcctg tgcagcctct ggattcacct tcagtaatta
       61 tggcttgcac tgggtccgcc aggctccagt gaaggggctg gagtgggttg cagttatatc
      121 gtatgatgaa aatgtgaaat tctacgcaga ctctgtaaag gaccgattca ccatctccag
      181 agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtgtattac tgtgcgagag gggaatacag taactctatt gactactggg gccagggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000607             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15361:15802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000607
VERSION     KCXD01000607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15361:15802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59089.1"
                     /translation="CARWEAASFDYW"
     D_segment       406..410
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           85 a          131 c          138 g          106 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtggtga agcctttgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccgtc agcggtggtt atggctggag ctggatccgc caggccccag ggaagggact
      241 ggagtggatt gggagtatct atggtcatag tggtagcacc cgctacaatc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga agctgacctc
      361 tgtgaccgcc gcggacacgg ccgtgtattt ctgtgcgaga tgggaagctg cctcttttga
      421 ctactggggt cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000608             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12874:14789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000608
VERSION     KCXD01000608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12874:14789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59090.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          122 c          147 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctccggt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000609             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11002:5319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000609
VERSION     KCXD01000609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11002:5319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59091.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          119 c          153 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttcg
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aagttggagg acacggccgt
      421 ctattactgt gcgagagacg catatggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000610             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20727:14281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000610
VERSION     KCXD01000610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20727:14281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59092.1"
                     /translation="CAREWIQWVQLVSGFDAW"
     D_segment       434..455
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..507
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          117 a          114 c          159 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag acgactcacc atgaagtttg ggctgaactg ggctttcctt gttgttattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg cggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtagc tatgccatac
      241 actgggtccg ccaggctcct gggaaggggc tggagtgggt ggcagtcata tcgtatgatg
      301 gaagtaagaa atactataca gactctgtga aggaccgatt cactatcacc agagacaatt
      361 ccaacaacat agtatatctt caaatgaacg acccgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag ggagtggata cagtgggtac agttagtgag cggtttcgat gcctggggcc
      481 aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000611             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23559:3513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000611
VERSION     KCXD01000611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23559:3513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59093.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       430..439
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          116 a          135 c          145 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agtacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaaaaccttc actgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ttgcatatga tgaaataatg
      301 gacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgca tactgaatac ttcgagttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01000612             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19023:3196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000612
VERSION     KCXD01000612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19023:3196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59094.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          141 c          153 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgggttgctc ctggaaatgg tgaaataata
      301 cacgcagaga gcttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000613             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:10009:9772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000613
VERSION     KCXD01000613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:10009:9772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..485
     V_segment       120..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59095.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       419..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>488
                     /gene="IGHG"
BASE COUNT          115 a          142 c          133 g           98 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagcg cagcacctca
       61 ccatggactg gacctggagg atcctcctct tagtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcaatct gggactgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac accttcagcg atttatccat acactggata cgacaggccc
      241 ctggaaaagg gcttcagtgg atgggaagtg ttgatcctgc ttttggtgaa atgataaacg
      301 cagagaagtt ccagggcaga gtcaccatga ccgaggacac gtcttcagac acagccttca
      361 tggaattgag cagcctgaaa tctgacgaca cggccgtgta tttctgtgcg agtggcccta
      421 gcggcacctg gatcgactgg tccttcgatg tctggggccc tggcacccca atcaccgtct
      481 cctcaacc
//
LOCUS       KCXD01000614             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10155:23031
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000614
VERSION     KCXD01000614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10155:23031"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59096.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       413..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          143 c          137 g           91 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtctt tctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccctca ccgaagtgtc cactcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggaa gtgttgctcc tgcatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtccacaga cacagcctac atggaattga
      361 gcagcctaag atctgaggac acggccgtgt attactgtgc gattggacct accggcaggt
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000615             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5690:8355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000615
VERSION     KCXD01000615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5690:8355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59097.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          124 c          159 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccagttgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaatt ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000616             389 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19920:4418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000616
VERSION     KCXD01000616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19920:4418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..387
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..387
     V_segment       24..317
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>356
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59098.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       331..336
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       343..387
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        388..>389
                     /gene="IGHG"
BASE COUNT           83 a           95 c          123 g           88 t
ORIGIN      
        1 acatggggaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
       61 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      121 acatgagttg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattgccg
      181 ctgatgggga tagcacatac tatgcagact ccatgaaggc cagattcact atctccagag
      241 agaacgccaa gaacacactg catcttcaaa tggacagcct gagagcagag gacacggctg
      301 tctattactg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gtctggggcc
      361 cgggagtcct gatcaccgtc tcctcagcc
//
LOCUS       KCXD01000617             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:25617:12620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000617
VERSION     KCXD01000617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:25617:12620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59099.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          117 c          158 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccgggaggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtatctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcag ttgaatcgtt
      301 tgatggaact aagaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 cagttccagg aacatgctgt atcttcaaat gaacaacctg aaactggagg acacggccgt
      421 ctattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000618             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21893:15703
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000618
VERSION     KCXD01000618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21893:15703"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..491
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59100.1"
                     /translation="CASGPTTIFGMLVTGLDFW"
     D_segment       421..433
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          141 c          134 g          103 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca actacaggcg cccactctga
      121 ggtccagctg gtgcagtctg ggtctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attctccatg cactgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagttgt tgatcctttg gataatgaaa taatatacgc
      301 agacaacttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggaactgagc agcctgacct ctgacgacac ggccatctat tactgtgcga gtgggcctac
      421 tacaattttt ggaatgcttg ttacggggct tgacttctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000619             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15824:14812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000619
VERSION     KCXD01000619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15824:14812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59101.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          119 c          150 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 gccctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttttgtcgt
      301 ctgatggaag ttacaaatac cacgcagact ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000620             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23834:17452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000620
VERSION     KCXD01000620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23834:17452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59102.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       399..407
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          136 c          140 g          104 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctctggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatgag cagtcactac tgcagctgga tccgccagtc cccagggaag ggactggagt
      241 ggattggacg gatctctggt agtggtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ctcaacagac acgtccaaga aggagatctc cctgaagctg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagagaaga ctatggtggt aattattatt
      421 ttaaccggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000621             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23281:9573
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000621
VERSION     KCXD01000621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23281:9573"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59103.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          124 c          157 g          117 t
ORIGIN      
        1 acatggggac ctctgggaga ggagcccagc cccagagttc ccaggcgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgtggc
      121 tcttttgaaa ggagtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gccggggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtcagg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tggtgggact accacaaatt atgcagactc cgtgaggggc agcttcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg aaagccgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat tattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000622             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18027:5748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000622
VERSION     KCXD01000622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18027:5748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..488
     V_segment       137..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59104.1"
                     /translation="CTGGAYANLDYW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          108 a          123 c          153 g          106 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg actgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagatggt ggagtctggg ggcggcttgg caaaacctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact actggatgaa
      241 ctgggtccgc cagactccag gaaaggggct ggagtgggtc tcagctatta attatgatgg
      301 gggtagcgca tactacgcag actccgtgaa gggccgattc accatttcca gagacaactc
      361 aaagagtacg ctctccctgc aaatgagcag cctgagagcg gaggacacgg ccgtatatta
      421 ctgtacgggc ggggcatacg ctaacctcga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000623             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13049:11109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000623
VERSION     KCXD01000623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13049:11109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59105.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          123 a          140 c          134 g          104 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgcaaga cttctggata ttccttcact cactacttca ttcactgggt gaggcaggcc
      241 cctggacaag gtcttgagtg gataggactg atcacccctc acaatgatca caaaacctac
      301 gcacagaact tccagggcag agtcaccatg actacggaca cgtccacgag cacagtctac
      361 atggagctga acagccttag atccgacgac acagccgtat attactgtgc gagagggggg
      421 gatatagaat actgtactgg tagtggttgt ggggaacttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000624             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12560:3893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000624
VERSION     KCXD01000624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12560:3893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59106.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          117 c          157 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcacaaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagacttt cctgcgcagc ctctggattc agcttcaatt attactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaatagtgg
      301 tggggaaagt acgtactatg cagagtccgt gaggggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactatttc ttcaaatgga cagcctgaga actgaggaca cggctgtcta
      421 ttactgtgtg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000625             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5276:18586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000625
VERSION     KCXD01000625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5276:18586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..484
     V_segment       121..407
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59107.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          119 a          140 c          133 g           94 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc atagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagg tggtgcagtc tggggctgag gtgaaggagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctgggaaag ggcttgagtg gatgggaagt gttgatcctc tatatggtga aatgaaacac
      301 acagagttcc atgccagatt caccatgacc gaggacacgt ctacagacac ggcctacatg
      361 gagctgagca gcctaagatc agaggacacg gccctgtatt actgtgcagt cggatatagc
      421 ggcagatgga acaactggta cttcgatctc tggggccctg gcaccccaat caccatctcc
      481 tcagcc
//
LOCUS       KCXD01000626             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17824:12612
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000626
VERSION     KCXD01000626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17824:12612"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..503
     V_segment       122..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59108.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       424..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          141 c          146 g          104 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ttggtgcagt ccggggctga ggtgaagagg cctggggcct cagtgaagct
      181 ctcctgcaag gctcctggat acatcttcag catatctgcc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gatcatccct cttgttggtg taacaaccta
      301 cgcacagaac ttccaggaca gagtcacgat taccgcggac acgtccacaa gcacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tatttctgtg cgagtggcgg
      421 cttcgaggat gataacggtc actattatac gacactaaca tttcacgagt ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000627             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21259:8502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000627
VERSION     KCXD01000627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21259:8502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59109.1"
                     /translation="CAIGPSGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          107 a          145 c          136 g           90 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaactgag
      361 cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggccctt ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000628             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9139:10523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000628
VERSION     KCXD01000628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9139:10523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59110.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       409..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           95 a          135 c          136 g          113 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcag agaccctgtc cctcacctgc gctgtctctg
      181 gaggctctct cagcggtggt tatgactgga gctggatccg ccagccccca gggaaggggc
      241 tggagtggat tggctatatc tatggtggta ctgggagcac cacctacaac ccgtccctca
      301 ggaatcgagt caccatttca aaagacacgt ccaagaacca gttgtccctg aagctgagct
      361 ctgtgaccgc cgcggacacg gccgtatatt attgtgcgag acagtgctgt tactatgatg
      421 actttttaga ctactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000629             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8871:15561
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000629
VERSION     KCXD01000629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8871:15561"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59111.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       439..445
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          101 a          121 c          159 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtcggggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcagct tcagttacta cttcatgagc
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattaa tagtggtggg
      301 gatgatacat actatgcaga ctccgtgaag ggccgattca ccttgtccag agagaacgcc
      361 aagaacacac tgtatcttca catggtcagc ctgagaggtg aggacacggc tgtctattac
      421 tgtgcgagag accgacgtgt acagtcgtta tcctggttcg atgtctgggg cccgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000630             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:9891:8204
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000630
VERSION     KCXD01000630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:9891:8204"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59112.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          108 a          119 c          162 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccgggaa aggggctgga gtgggtctca actattaata
      301 gtggtgggga caacacatat tacgcagact ccgtgaaggg ccgacttacc atttccagag
      361 acaactcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattactg tgttcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000631             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22921:11602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000631
VERSION     KCXD01000631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22921:11602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59113.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          139 c          151 g          105 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga gtatcctcct cttggtggca gcagctacag gcgccctctc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaggaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggttgggagg tgttgatcct gcaaatggtg aggtaataca
      301 cgcagatagt tttcagggca gagtcaccat gaccgaggac acgtctacac tcacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagagggcg
      421 gttcggtagc agcgtctggt ccaatctcgt ctatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000632             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23136:10723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000632
VERSION     KCXD01000632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23136:10723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59114.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       442..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          111 c          154 g          116 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccaatc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttc ctatggcata
      241 cactgggtcc gccagtctcc agggaagggg ctggagtggg tggcagttat atcgtatgat
      301 gaaactaaga agtactacgc agactctgtg agggaccgat tcaccatctc cagagacaat
      361 tccaaaaaca tggtatatct tcaaatgaac aacctgaaat tggaggacac ggccgtatat
      421 tactgtgtga gagatgtcag gggaacgggg tttgacttct ggggccaggg aggcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000633             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:20558:12916
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000633
VERSION     KCXD01000633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:20558:12916"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59115.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          140 c          153 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggggttgacc ctgcaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 gggttcggta gcagtgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01000634             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8567:3232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000634
VERSION     KCXD01000634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8567:3232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59116.1"
                     /translation="CAREYCTTHDCAGFFDYW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          135 c          139 g          108 t
ORIGIN      
        1 acatggggat cacaaaacaa ccgcatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agttggtgca gtccggggct gaggtcaaga agcctggggc cgcagtgaag
      181 gtttcctgca aggcttctgg attcaccctc gacaactatg gtatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccatgttgg tataataaat
      301 tacggtgagc ggttccagga cagagtcacg attagcgcgg acacgtccat gaatatagcc
      361 tacatggacc tgaccagcct gaaatccgac gacacggcca tctatttctg tgcgagagaa
      421 tactgtacta ctcatgattg cgccggcttc tttgactact ggggccaggg agtcctggtc
      481 accgtctctt cagcc
//
LOCUS       KCXD01000635             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17219:19524
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000635
VERSION     KCXD01000635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17219:19524"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59117.1"
                     /translation="CARDEGDVSGYRFGYW"
     D_segment       429..434
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          113 c          157 g          120 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagttggtg gcgtctggag gaggcttggt tcagcctggg
      181 gggtccctga aactctcctg tgcagcctct ggattcacct tcagtagcta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatttc gtttgatgga
      301 agtaagaaat actacgcaga ctctatgaag gaccgattca ccatctctag agacaattcc
      361 aagaacatgc tatatcttca actgaacaac ctgagattgg aggacacggc catgtattac
      421 tgtgcgaggg atgaggggga cgttagcggg taccgatttg gctactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000636             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11324:13562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000636
VERSION     KCXD01000636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11324:13562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..476
     V_segment       108..401
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59118.1"
                     /translation="CARDAGVGATILYYYDFW"
     D_segment       410..418
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          135 c          139 g          108 t
ORIGIN      
        1 acatgggggg gaaatgctct ctgagagtca tggacatcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcagctgc
      121 aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctctcc tgcagtgtct
      181 ctggtggctc cttcagtggt tactactgga actggatccg ccagccccca gggaagggac
      241 tggagtggat tgggtttatc ggcggtggta gtgggagcac cgaatacaac ccctccctca
      301 aaagtcgagt caccatttca agagacacgt ccaagaatca attctccctg aagctgacct
      361 ctgtgaccgc cgcggacacg gccgtttatt actgtgcgag agatgcggga gtgggagcca
      421 caatccttta ttactatgac ttctggggcc aggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000637             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18579:8894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000637
VERSION     KCXD01000637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18579:8894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59119.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          100 a          139 c          134 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccctca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatcagtgc tagtagtgga aacaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgcccaag aaccagttct ccctgatgct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagaga aatactatag tggtagttat
      421 aaacacaact ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000638             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13780:15477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000638
VERSION     KCXD01000638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13780:15477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..492
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59120.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       428..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>496
                     /gene="IGHG"
BASE COUNT          115 a          142 c          141 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aggcctgggg cctcagttaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaaata tccatgcact gggtgcgaca
      241 ggcccccgga aaaggacttg agtggatggg aagtgttgat cctgtgtata gtgaagaaat
      301 actcgcagat aatttccacg acagagtcac catgaccgag gacacgtcta caggcacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtatatttct gtgcggcggg
      421 ccttgggggg tatctagtgc ttactgaata cctcgaattc tggggccagg gcgccctggt
      481 caccgtctcc tccgcc
//
LOCUS       KCXD01000639             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10754:6704
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000639
VERSION     KCXD01000639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10754:6704"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59121.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          114 c          154 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagag cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttac
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctaagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatggaagt agaaaatact acccagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccgag gccaatgtgt atcttcaaat gaatgacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatg cgtatggttc cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000640             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:26474:10230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000640
VERSION     KCXD01000640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:26474:10230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    77..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        77..437
     V_segment       77..367
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <359..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59122.1"
                     /translation="CAKGETAAVYYGLDSW"
     D_segment       374..385
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       386..437
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT           92 a          116 c          132 g           99 t
ORIGIN      
        1 acatggggga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
       61 aagaggtgtc cggtgtgagg tgcagctggt cgagtccggg ggcggcttgg cgaagcctgg
      121 gggatccctg agactctcct gtgcagcctc tggattcacc ttcagtacct acgccattca
      181 ctgggtccgc caggctccag ggaagggact ggagtgggtc tcagccatta gtagtggtgg
      241 cagcacattc tacgcagcct ccgtgaaggg ccgattcacc atctccagag acaattcaaa
      301 gaacacgctc tccctacaaa tgaacagcct aacaactgag gacacggcca tgtattactg
      361 tgcgaaagga gaaacagctg cagtttacta cggtttggat tcctggggcc aaggggtcgt
      421 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000641             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19462:13127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000641
VERSION     KCXD01000641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19462:13127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..486
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59123.1"
                     /translation="CARRPLPYEDDYSYYLGIFDYW"
     D_segment       411..425
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT           99 a          134 c          141 g          114 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgtaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagc agtggtgaag ccttcagaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggtgattat ggctggaact ggatccgcca ggccccaggg aagggactgg
      241 agtggattgg gagtatttat ggtagtagtg gtaacaccta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgagg ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagaag accgcttccc tacgaggatg
      421 attacagtta ttatttgggg atctttgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01000642             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12872:12447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000642
VERSION     KCXD01000642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12872:12447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59124.1"
                     /translation="CARGIDNYHFSDTDFDYW"
     D_segment       456..463
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          118 a          115 c          149 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagttggtgg aatctggggg aggattggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccgtgta tcttcaaata aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactttagtg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000643             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16297:16725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000643
VERSION     KCXD01000643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16297:16725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..484
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59125.1"
                     /translation="CARYFNYEDDYGYSNTGGTDAFDFW"
     D_segment       395..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..484
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           95 a          137 c          136 g          118 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg tggctccatc
      181 agcaatagct tctggagctg gatccgccag cccccaggga cggggctgga gtggattggc
      241 tatatctttg gtggtactgg gagcaccaac tacaatccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggt tgacctctgt gaccgccgcg
      361 gacaccgccg tgtattactg tgcgagatat ttcaattacg aggatgatta cggttactct
      421 aacaccggtg gtactgatgc ttttgatttc tggggccaag gtctcagggt caccgtctct
      481 tcagcc
//
LOCUS       KCXD01000644             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:22031:5533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000644
VERSION     KCXD01000644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:22031:5533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59126.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       411..417
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          105 a          149 c          133 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtctccgg aaacaccttc accgaattgt ccatacactg ggtgcgacag
      241 gcccctggaa aggggcttga gtgggtggga agtgttgatc ccgcatatgg tgaaatgacg
      301 ttccagggca gagtcatcat gaccgaggac acgtctacag acacagccta catggaactg
      361 accagcctga catctgacga cacggccgtc tattactgtg cggttggccc tagtggcact
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc cagtcaccat ctcctcagcc
//
LOCUS       KCXD01000645             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12449:10488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000645
VERSION     KCXD01000645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12449:10488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59127.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          147 c          146 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtttggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggatggga gttgttgatc ctgccaatgg tgaagaaata
      301 cacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcgcctg gtccaacctc ttcaccggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000646             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22732:14881
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000646
VERSION     KCXD01000646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22732:14881"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59128.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          101 a          126 c          157 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactacttc
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tatttccagt
      301 ggtggggata gcacatactc tgcagactcc gtgaagggca gattcaccat ttccagagag
      361 aacgccaaga ccacactgta tcttcacatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg caagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000647             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19131:2952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000647
VERSION     KCXD01000647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19131:2952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59129.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          127 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtggggat aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag accacactgt atcttcacat ggacagcctg agagctgagg acacgactgt
      421 ctattactgt gcaagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000648             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16078:3151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000648
VERSION     KCXD01000648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16078:3151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59130.1"
                     /translation="CAAAYSGSWNSWYFDFW"
     D_segment       420..428
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          138 c          143 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccag
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc agcgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtgggg ggtgttgatc ctgtatatgg tgaaatgata
      301 cacgtagaga ggttccaggg cagagtcacc atgaccgagg acacatctac agacacggcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtttttctg tgcagccgca
      421 tacagtggca gttggaactc ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01000649             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14576:15707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000649
VERSION     KCXD01000649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14576:15707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59131.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       406..414
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          137 c          138 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctctcctgca ctgtctctgg
      181 tggctccttc agtggttact actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tttatcggtg gtggtagtgg gagcaccgaa tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaagag acacgtccaa aaatcaattc tccctgaagc tggcctctat
      361 ggccgccgcg gacacggccg tttatttctg tgccagagat gcgggagtgg gagccacaat
      421 cctttactac tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000650             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19792:10267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000650
VERSION     KCXD01000650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19792:10267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..509
     V_segment       134..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59132.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       429..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..509
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          104 a          124 c          158 g          125 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tctgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcagcttt ggcgatcatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccatcagta atactggtaa
      301 agccgtacac tacgctgact ccgtgaaggg ccgattcacc atttccagag acaacgccaa
      361 gaactcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg tgtattattg
      421 ttgtagcgat tactatagtg gtagttatta ctattggggc tacggcttgg attcctgggg
      481 ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01000651             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14837:9189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000651
VERSION     KCXD01000651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14837:9189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59133.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       404..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           97 a          140 c          136 g          105 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggttact actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tatatcagtg ctagtagtgg gaccaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaagag acacgtccaa gaacctcttc tccctgaacc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag aaatactata gtggtagtta
      421 taaacacaac tggttcgatg tctggggccc gggagtcctg gtcgccgtct cctcagcc
//
LOCUS       KCXD01000652             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:25789:13355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000652
VERSION     KCXD01000652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:25789:13355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59134.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       431..437
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          112 a          117 c          144 g          117 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccgg agtgaggtgc aactggtgga gtccggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactatg gcatgcactg
      241 ggtccgccag gctccaggga agggactgga gtgggtggca gttatttcgt ctgatggaag
      301 taagaaatac tacgcaacct ctgtgaggga ccgcttcacc atctccagag acaattccaa
      361 gaacatactt tatcttcaaa tgaacaacct gaaattggaa gacacggccg tctattactg
      421 tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000653             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16324:5671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000653
VERSION     KCXD01000653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16324:5671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59135.1"
                     /translation="CARYGDDDYSGNDYFFDFW"
     D_segment       412..421
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           96 a          137 c          133 g          111 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtagcta ctggaattgg atccgccagt ccccagggaa gggactggag
      241 tggattgggt acatctatgg tgctactggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcagca tttcaacaga cacgtccaag aaccagtttt ccctgaacct gaactctgta
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg gcgacgatga ctatagtggg
      421 aatgattact tctttgactt ctggggcctg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000654             277 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:16634:11046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000654
VERSION     KCXD01000654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 277)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 277)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:16634:11046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..275
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..275
     V_segment       8..214
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <206..>244
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59136.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       225..234
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       235..275
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        276..>277
                     /gene="IGHG"
BASE COUNT           72 a           66 c           78 g           61 t
ORIGIN      
        1 acatgggagt aattttggca tccactgggt ccgccaggct ccagggaagg gcctggagtg
       61 ggtggcagtt acatcgtctg atgaaagtaa gaaatactat gcagactctg tgaaggaccg
      121 attcaccatc tccagagaca attccaagaa tatgctatat cttcaaatga acaacctgaa
      181 gttggaggac acggccgtct attactgtgc gagagacgca tatggcagcg gctgtgacta
      241 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000655             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25449:18208
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000655
VERSION     KCXD01000655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25449:18208"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..496
     V_segment       139..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59137.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       437..442
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..496
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          112 c          152 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagaccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca cgttcagtaa ctatggaatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtacgat
      301 gaagataaga aatactacgc agactctctg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctttatct tcaaatgaac aacctgaaat tggaggacac ggccgtttat
      421 tactgtgcga ggaggccctg gagtgcagat gcttttgatt tctggggcca aggactcagg
      481 gtcaccgtct cttcagcc
//
LOCUS       KCXD01000656             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20163:17194
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000656
VERSION     KCXD01000656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20163:17194"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59138.1"
                     /translation="CAKRGWGGSWNGGHYFDYW"
     D_segment       447..460
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          110 a          129 c          163 g          115 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggcggag gcttggtcca
      181 gcctgggggg tctctgagac tctcctgtga agcctctgga ttcactttca gtagctatgc
      241 catgacctgg gtccgccagg ctccagggaa ggggctggaa tggatctcat acattactaa
      301 tggtggtgtt accacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcgatg gacacgctct ccctgcaaat gaacagcctg agagctgagg acacggccgt
      421 gtattactgt gcgaaaagag gatggggcgg cagctggaac ggggggcact actttgacta
      481 ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000657             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22010:17802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000657
VERSION     KCXD01000657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22010:17802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59139.1"
                     /translation="CAVGYSGRLNNWYFDLW"
     D_segment       415..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          118 a          147 c          129 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggc agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagact tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga ccagcctaag atctgaggac acggccctct attactgtgc agtcgggtat
      421 agcggcagat tgaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01000658             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16350:4517
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000658
VERSION     KCXD01000658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16350:4517"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..461
     V_segment       89..379
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <374..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59140.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       404..411
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           94 a          124 c          135 g          110 t
ORIGIN      
        1 acatgggagc acagaacaca gaggactcac catggagtct gggctgagct gggttttcct
       61 tgttgctttt ttaagaggtg tccagtgtga ggttcaactg gtggagtctg gaggagactt
      121 ggtccagcct ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttc
      181 ctatggcatg acctgggtcc gccaggctcc agggaagggg ctggagtggg tctcatacat
      241 tagtattggt ggtggtacca catcctacgc agactccgtg aagggccgat tcaccgtctc
      301 cagagacaac tcagagaaaa cgctctccct gcaaatgaac agcctgagac ctgacgacac
      361 ggccgtgtat tactgtgcgt cgaatctacg tggtaacacc tacacttact ggcggtcctt
      421 tgactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000659             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26718:9268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000659
VERSION     KCXD01000659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26718:9268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59141.1"
                     /translation="CASVRYSGYKYGPFDYW"
     D_segment       423..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          140 c          146 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacacctt caccgaacta gccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg cggtgttgac cctgtaaacg gtgaaatgac
      301 acacgcagag aagttccagg gcagagtctc catgaccgag gacacgtcca cagacacagt
      361 ctacatggaa ttgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagtgt
      421 ccgatacagc gggtacaaat acggcccgtt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000660             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8993:3767
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000660
VERSION     KCXD01000660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8993:3767"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..238
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <233..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59142.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       247..261
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           69 a           88 c           90 g           75 t
ORIGIN      
        1 acatgggtcc tgcaagcttt ccggatccac cttcaccgaa ttatccatac actgggtgcg
       61 acaggcccct ggaaaggggc ttgaatggat gggaggtgtt gctcctcttt atggtgaaat
      121 gatgcacgca gacaacttcc agggcagagt caccttgacc gaggacccgt ctacagacac
      181 agcctacatg gagctgagca gcctgacatc tgacgacacg gccgtgtatt actgtgcgcg
      241 tgggcctatt acaatttttg gcgtacttat tacggggctt gactactggg gccagggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000661             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:21012:15127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000661
VERSION     KCXD01000661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:21012:15127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59143.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          114 c          147 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacattgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acgctaactc tgtgaagagc cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000662             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:27984:10904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000662
VERSION     KCXD01000662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:27984:10904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59144.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..451
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          123 c          150 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgct
      121 gctattttaa gaggtgtcca gtgtgaggtc cacctggtgg agtctggagg aggcttcatt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcaccct cagtacctat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatggag gtaggaaata ctacgcagac tctttgaaag cccgattcac catatccaga
      361 gacaactcca agaacatagt atatcttcaa ctgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagaga tgtgtatggc tcggggcttg actactgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01000663             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17116:14181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000663
VERSION     KCXD01000663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17116:14181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59145.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          123 a          139 c          133 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggagaa gggcttgagt ggatgggaag tgttgatcct aaatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagtctga gatctgagga cacggccgta tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000664             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25729:7763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000664
VERSION     KCXD01000664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25729:7763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..475
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59146.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       422..427
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          111 a          136 c          137 g           93 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacagcttc aacatcgatg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcatcc ctcttgtcgg tataacaaac
      301 tacgcacaga agttccaggg cagagtctcg attaccgcgg acacgtccac aagcacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattactg tgcgatccaa
      421 gggaacagcc agtttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000665             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17536:13804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000665
VERSION     KCXD01000665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17536:13804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59147.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          112 c          147 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aattggtgga gtctggagga ggcttggttc
      181 agcctggggg gaccctgagg ctctcctgtg cagcctctgg attcaccttc agtaattatg
      241 gcttgcactg ggtccgccag gctccagtga aggggctgga gtgggttgca gttatatcgt
      301 atgatgaaaa tgtgaaattc tacgcagact ctgtaaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000666             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13198:20026
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000666
VERSION     KCXD01000666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13198:20026"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..318
     V_segment       8..242
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <234..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59148.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       243..251
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           69 a           87 c           86 g           78 t
ORIGIN      
        1 acatgggcac ctgcgctgtc tctggtggct ccatcagaag taactactgg agctggatcc
       61 gccagtcccc agggaaggga ctggagtgga taggttatgt ctatggtgat agtgggaaca
      121 ccgaatacaa cccctccctc aagagtcgag tcaccatttc aagagactcg tccaagaatc
      181 agttttccct gaagctgagt tctgtgaccg ccgcggacac cgccgtgtat cactgtgcga
      241 gatacagtta cggttccaac tacttctttg ggttctttga ctattggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000667             355 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17311:11879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000667
VERSION     KCXD01000667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 355)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 355)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17311:11879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..353
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..353
     V_segment       7..286
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <278..>322
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59149.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       287..291
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..353
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        354..>355
                     /gene="IGHG"
BASE COUNT           75 a           91 c          114 g           75 t
ORIGIN      
        1 acatggggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac tctcctgcgc
       61 agcctctgga ttcaacttca attactacta catgaactgg gtccgccagg ctccagggaa
      121 ggggctggag tggatctcag gtattgacag tggtggggat agcacatact atgcggactc
      181 cgtgaagggc agattcacca tctccagaga gaacgccaag aacacactgt atcttcaatt
      241 ggacagcctg agagctgagg acacggctgt ctattactgt gcgagagtgg tgggtggtgc
      301 cgcaggatac ttcgacttct ggggccaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000668             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14284:17179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000668
VERSION     KCXD01000668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14284:17179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59150.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000669             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13601:12367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000669
VERSION     KCXD01000669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13601:12367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..462
     V_segment       81..374
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <366..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59151.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       379..383
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           91 a          140 c          130 g          103 t
ORIGIN      
        1 acatggggat cctgtgcaag aacatgaagc acctgtggtt cttcctcctc ctggtggcag
       61 ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc gggcccagga ctggtgaagc
      121 cttcggagac cctgtccctc acctgcgctg tctctggtgg ctccttcagc acttcctact
      181 ggagctggat ccgccaggcc ccagggaagg gactggagtg gattggatat atctatgctg
      241 atagtgggac caccagctac aacccgtccc tcaagagtcg agtcaccatt tcaatagaca
      301 cgtccaagaa tctgtactcc ctgaaactga gctctgtgac cgccgcggac acggcctttt
      361 attactgtgc gagacgtcct actcgcacgc gggttctata tgaggcgaca ggggaagact
      421 ttgactcctg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000670             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21212:14417
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000670
VERSION     KCXD01000670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21212:14417"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59152.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          119 c          148 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 aaactaagca atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000671             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14798:16596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000671
VERSION     KCXD01000671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14798:16596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59153.1"
                     /translation="CASGGYEDDSGFYFPDFFDSW"
     D_segment       422..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          107 a          136 c          145 g          115 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgtccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgcaa ggctgctgga tacatcttta gtatctctgc catcagttgg gtgcgacagg
      241 cccctggaca gggacttgag tggatgggag ggatcatccc tcttgttggt gtaacaaata
      301 acgcacggaa gttccagggc agagtcacga ttaccgcgga cacgtccaca agcacagcct
      361 tcatggatct gagcagcctg agatctgagg acacggccgt ctattattgt gcgagcggtg
      421 gttacgagga tgattccggt ttttattttc cagacttctt tgactcctgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000672             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5367:9621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000672
VERSION     KCXD01000672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5367:9621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59154.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          110 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcttcggg gttcatcttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gtaacatcgt
      301 ctgatgaaag taagaaattc tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccca gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tctactattg tgggagagat gataatgggg tgattattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000673             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13606:18685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000673
VERSION     KCXD01000673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13606:18685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..494
     V_segment       131..424
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59155.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       434..440
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          110 a          119 c          149 g          118 t
ORIGIN      
        1 acatgggagg agcccagccc cagaattccc aggtgtttct gttcggcgat cagcacaaaa
       61 cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc tcttgaaagg
      121 tgtccagtgt gaggtgaagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc
      181 cctgagactc tcctgcgcag cctctggatt caggttcaat tattactaca tgagctgggt
      241 ccgccaggct ccagggaagg ggctggagtg gatctcaggt attaatagtg gtgggcaaat
      301 tacatactat gcagagtccg tgcagggcag attcaccatc tccagagaga acgccaagaa
      361 cacactatat cttcaaatgg acagcctgag aactgaggac acggctgtct attactgtgt
      421 gagagatcga cgtgtacagt cgttatcctg gttcgatgtc tggggcccgg gagccctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000674             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8200:10881
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000674
VERSION     KCXD01000674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8200:10881"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..467
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59156.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       408..417
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>471
                     /gene="IGHG"
BASE COUNT           92 a          141 c          130 g          108 t
ORIGIN      
        1 acatggggat ggtctctgag agtcatgggc ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccaataccta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat ttatctatgg tgctactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tctcaacaga cacgtccaag aaccagtttt ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtattattgt gcgagatatg atcagtggga tgattacctg
      421 tactactttg actactgggg ccagggagtc ctggtcaccg tctcctcgtc c
//
LOCUS       KCXD01000675             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9432:3678
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000675
VERSION     KCXD01000675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9432:3678"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..491
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59157.1"
                     /translation="CARDAGYGDTISVVDINMFPHFDYW"
     D_segment       412..435
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          101 a          136 c          140 g          116 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgttg tctctactgc
      181 ctccatcagt agttactggt ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggta atagtggtag tttttactac aacccttccc tcaacagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagagatgcc gggtatgggg atacgatatc
      421 agtagtcgat attaatatgt tcccccactt tgactactgg ggccagggag tcctggtcgc
      481 cgtctcctca gcc
//
LOCUS       KCXD01000676             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22380:5326
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000676
VERSION     KCXD01000676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22380:5326"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59158.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       402..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          138 c          139 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctctgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatg agcagtcact actgcagctg gatccgccag tccccaggga agggactgga
      241 gtggattgga cggatctctg gtagtggtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtcacc ctctcaacag acacgtccaa gaaggagatc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagagaa gactatggtg gtaattatta
      421 ctttaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000677             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4693:20695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000677
VERSION     KCXD01000677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4693:20695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..431
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59159.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          116 a          121 c          147 g          130 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 ttctatatta aaaggtgtcc agtgtgtgga gcatctggtg gagtctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct gaattcacct ttagtggcta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtcta gaatgggtat caggtattaa
      301 cattggcggt gacccatact acccagactc tgtgaagggt cgattcacca tctccagaga
      361 caacgccaag aactccttgt atcttcaaat gaacaacctg agacctgagg acactgctgt
      421 gtattattgt gtgaggggga tggataacta ccacttcagt aatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000678             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11974:8249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000678
VERSION     KCXD01000678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11974:8249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59160.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       426..433
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          110 a          140 c          144 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctgc agtgaagagg cctggggcct cagttaaggt
      181 ctcctgcaag gtttccggat actccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtgtatggtg aagaaataca
      301 cgcagagaat ttccaggaca gagtcaccat gaccgaggac acgtccacag acacagccta
      361 catggagctg agcagcctga gacgtgagga cacggccgtg tatttctgtg cggcgggcct
      421 tggggggtat ttagttctta ctgaatacct cgaattctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01000679             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12301:17388
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000679
VERSION     KCXD01000679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12301:17388"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59161.1"
                     /translation="CARADRGSSIDFW"
     D_segment       444..450
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          116 c          146 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaagac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 aattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctaagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcgg ttatatctta
      301 tgatgatgat aagaaatact acacagactc tttgaaggac cgattcacca tatccagaga
      361 caattccaag aacactcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgagagcgg atcgcggcag ttcaattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000680             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15597:14313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000680
VERSION     KCXD01000680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15597:14313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59162.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          135 c          150 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcga
      181 agcctggggg acccctgaga ctctcctgtg cagcctctgg attcaccttc aatacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattagta
      301 gtggtggtac cacatactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgac aactgaggac acggccgtat
      421 attactgtgc gaagggaggt agcagctctt tctactggta cttcgatatc cggggccctg
      481 gcaccccagt caccatctcc tcagcc
//
LOCUS       KCXD01000681             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7679:21218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000681
VERSION     KCXD01000681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7679:21218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59163.1"
                     /translation="CVRVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          121 c          157 g          117 t
ORIGIN      
        1 atggggctgg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagtaca tactatgcgg actccgtgaa ggccagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aattggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000682             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7570:7163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000682
VERSION     KCXD01000682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7570:7163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59164.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          140 c          151 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgagatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000683             339 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:23064:5181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000683
VERSION     KCXD01000683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 339)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 339)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:23064:5181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..337
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..337
     V_segment       152..252
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <244..>306
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59165.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       273..279
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..337
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        338..>339
                     /gene="IGHG"
BASE COUNT           72 a          106 c           96 g           65 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gagggcagag tcaccatgac cgaggacacg
      181 tctacactca cagcctacat ggagctgagc ggcctgagat ctgaggacac ggccgtgtat
      241 tactgtgcga gagggcaatt cggtaccagc gtctggtcca atctcgtcta tggtttggat
      301 tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000684             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11078:8543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000684
VERSION     KCXD01000684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11078:8543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59166.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       431..436
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           95 a          149 c          132 g          113 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggctacta ctggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc atatcagtgg gagtagtggg agcaccgact acaacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag agccacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagt tttcccccta cgactattct
      421 tggagtgatt tttactctta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01000685             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22605:16848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000685
VERSION     KCXD01000685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22605:16848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59167.1"
                     /translation="CATGFGGSWTRFDYW"
     D_segment       411..416
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           90 a          133 c          134 g          108 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gtagtaacta ctggagttgg atccgccagg ccccagggaa gggactggaa
      241 tggattggat atatctttgg tagtggcagt gacaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaac aatcagctct ccctggagct gagctctgtg
      361 accgccgcgg acacggccct ttattattgt gcgaccgggt ttggtggcag ttggaccaga
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000686             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:10021:4970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000686
VERSION     KCXD01000686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:10021:4970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59168.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          111 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acatagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatgcta tattttcaaa tgaacaacct gaaattggaa gacacggccg
      421 tgtattactg tgcgagagat gtctatggca ggggacttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000687             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11297:8029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000687
VERSION     KCXD01000687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11297:8029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..513
     V_segment       141..434
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59169.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       451..464
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          107 a          122 c          157 g          129 t
ORIGIN      
        1 acatggggga gctctgagac aggagtctta gccctggatt ccaagaactt ccactttggg
       61 atcagctctg aacacagagg accatggagt tggggctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagtgt gaggtggagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggggggtc cctgagactc tcctgtgtag cctctggatt cacctttggt gattatggca
      241 tgcactgggt ccgccaggct ccgggaaagg gactggagtg ggtctcatcc attagaaaca
      301 ctggtaaaat cgtatactac gctgactccg tgaagggccg attcatcatc tccagagaca
      361 acgccaagaa ttcgctgttt ctgcaaatga gcagcctgag agtcgaggac tcggccgtct
      421 attactgtac tagaattggc gtcggatctc tagcaccggc tggtgaatac tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000688             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12588:12376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000688
VERSION     KCXD01000688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12588:12376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..502
     V_segment       122..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59170.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       422..435
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>508
                     /gene="IGHG"
BASE COUNT          114 a          139 c          147 g          108 t
ORIGIN      
        1 acatggggca cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccac ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag gcttctggat acaccttcag catctcttcc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgggt ggataggagg gatcatccct cttgttggta tgacaaacta
      301 cgaacaggag ttccagggca gagtcacgat taccgcggac acgtccacga atacagtctt
      361 catggaactg agcagcctga gatcggagga cacggccgtc tactattgtg cgacaggggt
      421 atattaccag gatgaaaacg gttattttta tgtcggcggg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct ccccagcc
//
LOCUS       KCXD01000689             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17939:14773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000689
VERSION     KCXD01000689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17939:14773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59171.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          116 a          143 c          129 g           90 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggga aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccact tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000690             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:26884:14682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000690
VERSION     KCXD01000690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:26884:14682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59172.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          122 c          159 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtcgggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagcctc tggtttcaga ttcagttact acttcatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggataataca tactatgcag actccgtgaa gggccgattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc acatggacag cctgagaggt gaggacacgg ctgtctatta
      421 ctgtgcgaga gaccgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000691             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11428:15391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000691
VERSION     KCXD01000691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11428:15391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59173.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          113 c          151 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aattggtgga gtctggagga ggtttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcttctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taggaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattctaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcgtca gcc
//
LOCUS       KCXD01000692             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20177:7015
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000692
VERSION     KCXD01000692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20177:7015"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59174.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga cctattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000693             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5775:15892
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000693
VERSION     KCXD01000693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5775:15892"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..472
     V_segment       121..395
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59175.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       404..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          114 a          134 c          135 g           91 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc agagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tgatgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg ttaccggata caccttcacc gaattatcca tgcgctgggt gcgacaggcc
      241 cctggaaaag gacttgagtg gatgggaagt gttgatcctg tatatggtga aatgaaagag
      301 ggcagagtca ccatgaccga ggacacgtct acagacacag cctacatgga actgagtagc
      361 ctgagatctg aggatacggc cgtgtattat tgtgcagtcg gcaatagcgg cagctggatc
      421 tcctggtcct tcgatgtctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01000694             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9062:4503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000694
VERSION     KCXD01000694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9062:4503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59176.1"
                     /translation="CASGPSGTWNGWYFDIW"
     D_segment       430..440
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          145 c          139 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggcggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tcaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgacg
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 cgagacagag aacttccagg gcagagtcac cctgaccgag gacacgtcta tagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga ggactcggcc gtgtattact gtgcgagtgg
      421 ccctagcggc acctggaacg gctggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000695             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16662:5215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000695
VERSION     KCXD01000695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16662:5215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59177.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           94 a          149 c          132 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccacga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggctactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actattcttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000696             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23309:18551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000696
VERSION     KCXD01000696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23309:18551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..480
     V_segment       114..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59178.1"
                     /translation="CATSSSGTWLYWYFDLW"
     D_segment       419..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          119 a          139 c          130 g           94 t
ORIGIN      
        1 acatgggaac aaccacatcc ctcccctaca gaagccccag agcacagcac ctcaccatgg
       61 actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac tctgaggtcc
      121 agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag gtctcctgca
      181 aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag gcccctggaa
      241 aagggcttga gtggatggga agtgttgatc ctaaatatgg tgaaatgata gacgccgaga
      301 aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagcagtct gagatccgag gacacggccg tatattactg tgcgacatca tccagcggca
      421 cctggctata ctggtacttc gatctctggg gccctggctc cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01000697             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14692:3182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000697
VERSION     KCXD01000697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14692:3182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59179.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       430..437
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          114 a          124 c          148 g          106 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattactg tgcgagtggg
      421 tttagtattt ggttatttta cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01000698             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:8939:15556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000698
VERSION     KCXD01000698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:8939:15556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59180.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          116 a          145 c          138 g           93 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gacgtgaaga agcctggggc ctctgtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacacagaga agttccaggg cagaggcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatatctggg gccctggcac ccctatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01000699             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17022:9466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000699
VERSION     KCXD01000699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17022:9466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59181.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       412..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          138 c          134 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tttctggtga
      181 ctccatcaac agtggctact actggagctg gatccgccaa tccccaggga aggggctgga
      241 gtggcttggg tttgtcggtg gtagtagagg tatcacctac tacaagtcct ccctcaagag
      301 tcgagtcacc ctttcaaaag acacgtccag gaaccagttc tccctgaaac tgagcgctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaaaa cttccaggtc tgcaactaac
      421 cggtttcgat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000700             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18147:6279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000700
VERSION     KCXD01000700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18147:6279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59182.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           99 a          145 c          135 g          107 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgtcctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtcgat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000701             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21548:10485
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000701
VERSION     KCXD01000701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21548:10485"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59183.1"
                     /translation="CARGLGSSAHFGLDAW"
     D_segment       420..427
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          102 a          140 c          145 g           97 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccagctg gtgcagtccg gggctgatgt gaagaagcct ggggcctcag tgaagctctc
      181 ctgcaaggcc tctggattcg ccttcaacat gtatgccctc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagggat cgtccctctc cttggaacaa caaactccgc
      301 acagaagttc cagggcagag tcacgattac cgcggacacg tccataagta cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcga gaggcctggg
      421 cagcagcgcc cactttggtt tggatgcctg gggccaaggg gtcgtcgtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000702             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19690:19522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000702
VERSION     KCXD01000702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19690:19522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59184.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       452..460
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          117 a          116 c          151 g          120 t
ORIGIN      
        1 acatggggga ggtctgggag aggagcccag ccctggaagt ccacagtgtt ccactcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttatt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatgaaa ttaagaaata ctacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga ggagagattt ggctacagtt ttgacttctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000703             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15116:13296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000703
VERSION     KCXD01000703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15116:13296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59185.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       412..421
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          143 c          136 g          101 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggc
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccctcagaga ccctgtccct cacctgcgct gtctctggtg
      181 cctccatcgg tagttactgg tggacctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatgga aatagtggta gtacctacta tagcccctct ctcaagagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga accacctctc cctgaagctg aactctgtga
      361 ccaccgcgga cacggccgtg tatttctgtg cgaacgtctt aggcccctgg ggcagctggt
      421 cacactactt tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000704             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23810:13077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000704
VERSION     KCXD01000704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23810:13077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59186.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       438..443
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          110 c          155 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga agtgcaactg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca gcttcagtgg ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttac atcgtttgat
      301 gaaactaaga aatattacgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tgctgtattt tcaattgaac aacctgaaat tggaagacac ggccgtgtat
      421 ttctgtgcga gagatgtcta tggcagggga cttgactact ggggcctggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000705             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7954:14076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000705
VERSION     KCXD01000705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7954:14076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59187.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       445..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          115 c          153 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt cctttcggtg
       61 atcagcacag agcacagagg actcaccatg aagtttgggc tgaactgggt tttccttgtt
      121 actattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtattttt
      241 ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 aatgatggaa gtaaaaaata ctactcagac tctgtgaagg accgattcac catctccaga
      361 gacaactccg aggccagtgt ctatcttcaa atgaataacc tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga tgcgtatggt tccggcttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01000706             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16125:15282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000706
VERSION     KCXD01000706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16125:15282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59188.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          112 a          117 c          154 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcaattatt actatatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atagtggtgg
      301 ggaaagcaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaaaaca gtatatcttc aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcctt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000707             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20725:16148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000707
VERSION     KCXD01000707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20725:16148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..506
     V_segment       137..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59189.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       433..454
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..506
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          116 a          119 c          157 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc aggcctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg tctgacctgg gttttccttg ttggtatttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggagccttgg ctcagcctgg
      181 ggggtccctg agactctcct gtgcagcgtc tgggttcacc ttcagtagct atgccatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagccatat catttgatgg
      301 aagtaagaaa aactacgcag actctgtgaa ggaccgattc accatctcca gagacaactc
      361 caacaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtatacta
      421 ctgttcgagg gagtggatac agtgggcaca gttagtgagc ggtttggatt cctggggcca
      481 aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01000708             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:12925:11822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000708
VERSION     KCXD01000708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:12925:11822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..260
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59190.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       264..279
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           76 a           93 c           85 g           69 t
ORIGIN      
        1 acatgggggg ggagtctctg aagatctcct gtaagacttc tggatacagc tttaccacca
       61 actggatcag ttgggtgcgc cagacgcccg gaaaaggcct ggaatggatg gggaccatct
      121 atcctgctga ttctgaggcc aaatacaacc cgtccttcca aggccacgtc actatctcag
      181 ccgacaagtc catcagtacc acctacctgc agtggagcag cctgaaggcc tcggacaccg
      241 ccacgtattt ctgtgcgaaa acctactata gtggtagttt ggaaatctgg ggccagggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000709             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:27441:8047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000709
VERSION     KCXD01000709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:27441:8047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59191.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          112 c          148 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagcacc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcatatgatg
      301 aaactaagaa atactacaca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatttt caaatgaaca acctgaaatt ggaggacacg gccatatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000710             526 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:5766:11805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000710
VERSION     KCXD01000710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 526)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 526)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:5766:11805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    170..524
                     /note="immunoglobulin heavy chain variable region"
     V_region        170..524
     V_segment       170..449
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <443..>493
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59192.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       463..473
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..524
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        525..>526
                     /gene="IGHG"
BASE COUNT          119 a          156 c          148 g          103 t
ORIGIN      
        1 acatggggga ctggtgtctg ccgaggtaaa tacagatctg tccttgtcca gagagcatca
       61 cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca ccatggactg
      121 gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg aagtccagct
      181 ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgagggtct cctgcaggat
      241 ttccggatac accttcaccg aattatccat acactgggtg cggcaggccc ctggaaaagg
      301 gcttgagtgg atgggaaggg ttgatcctct gtatggtgaa atgaagttcc agggcagagt
      361 caccatgacc gaggacacgt ctacagacac agcctacttg gaactgagcg gcctgacttc
      421 tgaggacacg gccgtgtatt actgtgcgac tggccctacc ggcacctgga acgcctggta
      481 cctcgatatc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01000711             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16978:16071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000711
VERSION     KCXD01000711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16978:16071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59193.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          116 c          148 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaattttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt cacaaatact acgccaactc tgtgaagagc cgattcgcca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000712             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13887:12064
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000712
VERSION     KCXD01000712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13887:12064"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59194.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       399..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           99 a          135 c          137 g          113 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
      121 gggcccagga ctgatgaagc cttcagagac cctgtccctc agctgcgctg tctctggtgg
      181 ctccataagt ggtaactggt ggagctggat ccgccagccc ccagggaagg gactggactg
      241 gattggacgt atctctggta ctagtgggga caccaattac aatccctccc tcaagagtct
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga actctgtgac
      361 cgccgcggac gcggccgtgt attattgtgc aagagcggat tacgaggatg attacggtta
      421 tcatttagga tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000713             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10596:16833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000713
VERSION     KCXD01000713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10596:16833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59195.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       417..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          120 a          141 c          133 g           94 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagga gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagcctaaga tcagaggaca cggccctgta ttactgtgca gtcggatata
      421 gcggcagatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01000714             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16681:12291
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000714
VERSION     KCXD01000714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16681:12291"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59196.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          112 c          148 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cgttcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtgc aattggtgga gtctggagga ggcttgattc
      181 agcctggggg gtccctgagg ctctcctgtg cagcctctgg attcaccttc agtaattatg
      241 gcttgcactg ggtccgccag gctccagtga aggggctgga gtgggttgca gttatatcgt
      301 atgatgaaaa tgtgaaatac tacgcagact ctgtaaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000715             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:8208:10920
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000715
VERSION     KCXD01000715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:8208:10920"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..467
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59197.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       407..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>470
                     /gene="IGHG"
BASE COUNT           94 a          140 c          129 g          107 t
ORIGIN      
        1 acatgggggg gtctctgaga gtcatgggcc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcac caatacctac tggaactgga tccgccagcc cccagggaag gggctggaat
      241 ggattggatt tatctatggt gctactggga gcaccggcta caacccctcc ctcaagagtc
      301 gagtcaccat ctcaacagac acgtccaaga accaattttc cctgaagctg agctctgtga
      361 ccgccgcgga caccgccgtg tattactgtg cgagatatga tcagtgggat gattacctgt
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcatcc
//
LOCUS       KCXD01000716             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:24346:5578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000716
VERSION     KCXD01000716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:24346:5578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59198.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          111 a          144 c          135 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaactg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01000717             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15228:12828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000717
VERSION     KCXD01000717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15228:12828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59199.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          117 c          151 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcgac
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttttggcg
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt atatcgtctg
      301 atgaaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa gttggaggac acggccgtct
      421 attactgtgc gagagacgta tatggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000718             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13284:15033
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000718
VERSION     KCXD01000718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13284:15033"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59200.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       441..446
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          113 c          158 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      181 cagccggggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtactttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaataaata ctacgcagac tctgtgaagg cccgattcac cgtctccaga
      361 gacaattcca agaacatgtt atatcttcaa atggacaacc tgaaattgga agacacggcc
      421 gtgtattact gcgcgagaga tgtctggggg aggggatttg actattgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000719             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16427:12241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000719
VERSION     KCXD01000719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16427:12241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..498
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59201.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>504
                     /gene="IGHG"
BASE COUNT          119 a          142 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aagtttccgg atacacggtc atcgatttat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgaacatgg tgaagtaata
      301 tacgcagaca acttccaggg cagagtcgcc atgagcgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcgacccac
      421 ggaggatata gaggcatctg gaactcccta tactacggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcccc agcc
//
LOCUS       KCXD01000720             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14710:12197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000720
VERSION     KCXD01000720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14710:12197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59202.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       412..419
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          103 a          136 c          150 g          105 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctataga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacacgttc agcatctatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tataacaaac tacgcacaga
      301 ggttccaggg cagagtcacg atttccgcgg acacgtccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagggga gattgtactg
      421 atactgactg ctcttccgcg gggggcgcct ttgatttctg gggccaaggg ctcagggtca
      481 ccgtctcttc agcc
//
LOCUS       KCXD01000721             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13406:8834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000721
VERSION     KCXD01000721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13406:8834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59203.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       442..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          121 c          147 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca ctacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgtt
      301 tgatgaaact aaggaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gtgagagatt cttacggccg aggctttgac tcctggggcc agggattcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000722             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11355:14019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000722
VERSION     KCXD01000722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11355:14019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59204.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       435..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          114 c          150 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccggtgt gaggtgcaac tggtggagtc tggagggggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcatctg
      301 atggaagtaa caaatactac gcaaactctg tgaaggaccg atttaccatc tccagagaca
      361 attccaagaa catagtatat cttcaaatga acaacctgaa atcggaggac acggccgtct
      421 attactgtgc gagagatgat atggggaccg gttttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000723             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15380:11644
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000723
VERSION     KCXD01000723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15380:11644"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..458
     V_segment       83..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59205.1"
                     /translation="CARVQGGSYYYGGGYFEFW"
     D_segment       387..403
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..458
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT          100 a          137 c          117 g          106 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcac tttctctggg ttctcattca gttcttctgg
      181 aacaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaagcat
      241 ttattggaat gatactaaat tccacagcac aacgctgaag ttcaggctca ccatctccaa
      301 ggacacctcc aaaaaccagg tggttctaac aataaccaac gtggaccctg tggacacagc
      361 cacatattac tgtgcacggg tacaaggtgg tagttattac tacggtgggg gatacttcga
      421 gttctggggc cagggcgccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000724             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20102:10367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000724
VERSION     KCXD01000724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20102:10367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59206.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       436..447
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          104 a          128 c          159 g          110 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagcactgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg ggggcggctt ggcaaagcct
      181 gggggatccc tgagactctc ctgtgcagcc tctggattca ccttcaatac ctatgctata
      241 cactgggtcc gccaggctcc cgggaagggg ctggactggg tctcagccat tagtagtggt
      301 gggcgcacat actacgcaga ctccgtgaag ggccgagtca ccatctccag agacaactca
      361 aagaacacgg tctccctgca aatgaacagc ctgggagctg aggacacggc cgtgttttac
      421 tgtgcgagag gggagacagc ttcagtttac tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01000725             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22271:5989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000725
VERSION     KCXD01000725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22271:5989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59207.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          116 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggagggg gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcatc
      301 tgatggaagt aacaaatact acgcaaactc tgtgaaggac cgatttacca tctccagaga
      361 caattccaag aacatagtat atcttcaaat gaacaacctg aaatcggagg acacggccgt
      421 ctattcctgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000726             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16937:2970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000726
VERSION     KCXD01000726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16937:2970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59208.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          115 c          158 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaaggc ccgagtcacc gtctccagag
      361 acaaatccaa gaacatgtta tatcttcaaa tggacaacct gaaattggaa gacacggccg
      421 tctattactg cgcgagagat gtctggggga ggggatttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000727             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:24474:15303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000727
VERSION     KCXD01000727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:24474:15303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <418..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59209.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       433..444
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          104 a          128 c          156 g          110 t
ORIGIN      
        1 acatggggga gaggagccca gcactggaag tccacagtgt tccattcggt gatcagcact
       61 gaacacagag gactcaccat ggagtctggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcaactggtg gagtctgggg gcggcttggc aaagcctggg
      181 ggatccctga gactctcctg tgcagcctct ggattcacct tcaataccta tgctatacac
      241 tgggtccgcc aggctcccgg gaaggggctg gactgggtct cagccattag tagtggtggg
      301 cgcacatact acgcagactc cgtgaagggc cgagtcacca tctccagaga caactcaaag
      361 aacacggtct ccctgcaaat gaacagcctg ggagctgagg acacggccgt gttttactgt
      421 gcgagagggg agacagcttc agtttactac ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000728             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:24961:14151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000728
VERSION     KCXD01000728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:24961:14151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59210.1"
                     /translation="CARWSWRAATMRGALDRW"
     D_segment       409..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..470
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           87 a          141 c          144 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag gacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtcactggt ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggggaa atcaatggta atagtggggg caccaactac aacccctacc tcaagagtcg
      301 agtcaccatt tctagagacg cgtccaagaa ccagttctcc ctgaacctga gctctctgac
      361 cgccgcggac acggccgtgt atttctgtgc gagatggtcc tggagggcag caactatgcg
      421 tggggcctta gaccgctggg gccagggcgt cctggtctcc gtctcctcag cc
//
LOCUS       KCXD01000729             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22350:14564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000729
VERSION     KCXD01000729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22350:14564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..460
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59211.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..411
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          141 c          132 g          100 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagca gtacctactg gagctggatc cgccagcccc cagggaaggg actggagtgg
      241 attggacgta tctctggtgg tggtgggaac accgactaca acccctccct caagagtcga
      301 gtcaccattt caagagacac gtccaggaac cacctctccc tgcagctgaa ttatgtgacc
      361 gccgcggaca cggccgtgta ttattgtgcg agaacaagcg gtggctggtc cccctacttt
      421 gactattggg gccagggagt cctggtcacc gtttcctcag cc
//
LOCUS       KCXD01000730             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12338:19414
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000730
VERSION     KCXD01000730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12338:19414"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..494
     V_segment       137..425
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59212.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       440..445
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          105 a          118 c          158 g          115 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg cacagcctgg
      181 ggggtccctg agactctcct gttcagcctc tggattcacc ttcagtagac actggatgaa
      241 ctgggtccgc caggctccag gaaaggggct agagtgggtc tccggtatta atagtggtgg
      301 ggatactaca tactacgcag actccgtgaa gggccgattc accatgtcca gagacaactc
      361 aaagaacact ctctccctgc aaatgaacag cctgagagcg gaggacacgg ccgtgtatta
      421 ttgtgtccaa ggggaaattt ttggagtggg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01000731             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12282:12775
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000731
VERSION     KCXD01000731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12282:12775"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59213.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          137 c          127 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tacaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcggc aatagctact ggaactggat ccgccagccc ccagggaagg gtctggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000732             423 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24245:15297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000732
VERSION     KCXD01000732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 423)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 423)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24245:15297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    67..421
                     /note="immunoglobulin heavy chain variable region"
     V_region        67..421
     V_segment       67..345
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <340..>390
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59214.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       354..361
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       371..421
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        422..>423
                     /gene="IGHG"
BASE COUNT           86 a          123 c          125 g           89 t
ORIGIN      
        1 acatgggcca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
       61 cactctgagg tccttctggt gcagtctggg gctgaggtga tgcagcccgg ggcctcagtg
      121 aaggtctcct gcaaggtttc cggaaacacc ttcaccgaat tgtccataca ctgggtgcga
      181 caggcccctg gaaaagggct tgagtgggtg ggaagtgttg atcccgcata tggtgaaatg
      241 acattccagg gcagagtctt catgaccgag gacacgtcta cagacacagc ctacatggag
      301 ctgaccagcc tgacatctga cgacgcggcc gtctattact gtgcggttgg ccctagcggc
      361 acttggaacc actggtcctt cgatatctgg ggccctggca ccccaatcac catctcctca
      421 gcc
//
LOCUS       KCXD01000733             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12730:15382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000733
VERSION     KCXD01000733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12730:15382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59215.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          115 c          148 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagagaagt ccaatgtgag gtgcacctgg tggaatctgg aggaggttcg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcattc
      241 actgggtccg ccaggctccg gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaacaacat ggtatatctt caaatgaaca acctgaaatt agaggacacg gccgtgtatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000734             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14357:11873
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000734
VERSION     KCXD01000734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14357:11873"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..502
     V_segment       133..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59216.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       429..442
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          119 c          159 g          116 t
ORIGIN      
        1 acatggggag gagcccaggc ctggaagtcc acagtgttcc attcggtgat cagcacagaa
       61 cacagaggac tcaccatgaa gtttggtctg acctgggttt tccttgttgg tcttttgaaa
      121 ggtgtccagt gtgaggtgca gctggtggag tctggaggag ccttggctca gcctgggggg
      181 tccctgagac tctcctgtgc agcgtctggg ttcaccttca gtagctatgc catgcactgg
      241 gtccgccagg ctccagggaa ggggctggag tgggtggcag ccatatcgtt tgatggaagt
      301 aagaagaact acgcagactc tgtgaaggac cgattcacca tctccagaga caactccaag
      361 aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt gtactactgt
      421 tcgagggagt ggatacagtg ggcgcagtta gtgagcggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000735             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21452:13056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000735
VERSION     KCXD01000735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21452:13056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..395
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59217.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       402..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           91 a          136 c          130 g          102 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctaca attgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca acatttacta ctggaattgg atccgccagg ccccagggaa gggactggac
      241 tggattggac atatctatgg tagcggtggt agcaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtgga cacgtccaag aaccacttct ccctgaacct gaggtctgtg
      361 accgccgcgg acacggccgt atattactgt gcgagcggtc ggcggcagct ggactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000736             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15004:17220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000736
VERSION     KCXD01000736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15004:17220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59218.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          145 c          132 g           97 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactgcag gcgcccgctc
      121 tgaggtccac ctggtgcaat ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaaa ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagtctga gatctgaaga cacggccctg tattactgtg cgacatcacc
      421 cagcggcacc tggctatttt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000737             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14663:19795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000737
VERSION     KCXD01000737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14663:19795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59219.1"
                     /translation="CVRGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          150 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg atttaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttacgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgtgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000738             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17721:14165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000738
VERSION     KCXD01000738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17721:14165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59220.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          127 c          159 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcccggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatattac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa cacgctctcc ctgcaaatga acagcctgac agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggccgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01000739             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13163:9763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000739
VERSION     KCXD01000739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13163:9763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59221.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       434..445
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          115 c          151 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cattgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactgtcct gtgcagcctc tggattcacc ttcattaact atggcatgca
      241 ctgggtccgc caggctccag ggaagggtct ggagtgggtg gcagttatgt cgcatgatgg
      301 aactaagaaa ttctacgcag actctgtgaa ggaccgattc accatctcca gggacaattc
      361 caagaacatg gtatatcttc aaatgaacaa cctgagattg gaggacgcgg ccgtgtatta
      421 ctgtgcgaga ggagactacg gtaacagcct tgactactgg ggccagggag tcctgctcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000740             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6883:21267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000740
VERSION     KCXD01000740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6883:21267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..456
     V_segment       101..395
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59222.1"
                     /translation="CARMWYWPTPDVW"
     D_segment       401..407
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..456
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           83 a          131 c          141 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaggc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 ctccatcagc ggtggttatg gctggaactg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtctctttg gcagtagtgg aagaacctac tacaatccgt ccctcaagag
      301 tcgagtcgct atttcaaaag acacgtccaa gaaccagttc tccctgatcc tgaggtctgt
      361 gaccgccgcg gacggccgtg tattactgtg cgagaatgtg gtactggccg acccccgatg
      421 tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000741             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20915:9831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000741
VERSION     KCXD01000741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20915:9831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..309
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..309
     V_segment       8..250
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <243..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59223.1"
                     /translation="CASSDYGWFDVW"
     D_segment       255..263
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       265..309
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        310..>311
                     /gene="IGHG"
BASE COUNT           66 a           84 c           87 g           74 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ttgtctctgg tggcgatagt tataggtgga
       61 gctggatccg ccagccccca gggaagggac tggaatggat tgggtatatt tatggtagta
      121 ttacggacac caactacaac ccctccctca aaagtcgagt caccatttca aaagacacgt
      181 ccaagaagca gttctccttg aaactgagct ctgtgaccgt cgcggacacg gccgtgtatt
      241 tctgtgcgag ttcagactac ggttggttcg atgtctgggg cccgggagtc ctggtcaccg
      301 tctcctcagc c
//
LOCUS       KCXD01000742             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21873:4213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000742
VERSION     KCXD01000742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21873:4213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59224.1"
                     /translation="CARYGDDSVHYNFDSW"
     D_segment       403..410
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          138 c          131 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 ggccccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtggcttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atctatggta gtactgggag caccggctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtcaaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac accgccgtgt atttctgtgc gagatatgga gatgatagtg ttcattacaa
      421 ctttgactcc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000743             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22000:9956
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000743
VERSION     KCXD01000743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22000:9956"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59225.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          112 c          153 g          117 t
ORIGIN      
        1 acatgggagg tctgggagag gagcccagcc ctggaagtcc acagtgttcc aatcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaattct acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgagagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000744             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24237:12410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000744
VERSION     KCXD01000744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24237:12410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59226.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          114 c          151 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtaactatg
      241 gaatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01000745             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24911:3686
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000745
VERSION     KCXD01000745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24911:3686"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59227.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          144 c          138 g          100 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtctcc
      121 agtcccaggt ccacctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 cggtttcctg cggggcctct ggattcacct tcgacaccca tggaatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat cccccttatt ggtatcacaa
      301 actacgcaaa gaactctcag ggcagagtca caataaccgc gaacacgtcc acaaacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc catctattat tgtgcgagag
      421 aatactgtac ttctagtagt tgcgccgggt tccttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000746             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16548:9382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000746
VERSION     KCXD01000746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16548:9382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59228.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          141 c          136 g           99 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaag ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgta tattactgtg cgacatcacc
      421 cagcggcaat tggctttttt ggtacttcga tttttggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000747             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12836:14671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000747
VERSION     KCXD01000747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12836:14671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59229.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       432..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          115 c          143 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctccc gggaagggtc tggagtgggt agcagttatc tcccatgatg
      301 aaaataatat atattacgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacaa cgtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtttt
      421 actgtgtgag agatacattc ggttcaggat ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000748             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21673:2293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000748
VERSION     KCXD01000748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21673:2293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    159..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        159..342
     V_segment       159..269
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59230.1"
                     /translation="CARYDADDYGYYFLDYW"
     D_segment       281..290
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..342
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           68 a          105 c           92 g           79 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctccctcaag agtcgagtca
      181 ccatctcaac agacacgtcc aacaaccact tttccctgag gctgaactct gtgaccgccg
      241 cggacaccgc cgtgtattac tgtgcgagat atgacgcgga tgactacggt tattatttcc
      301 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000749             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17030:9254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000749
VERSION     KCXD01000749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17030:9254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59231.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       423..443
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          146 c          141 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagccacc ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagttaagaa gcctggggcc tcagtgatgg
      181 tctcctgcca ggtttccgga tacaccgtca ccgaaatttc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgctcc tgaaaaaaat gagttaatac
      301 acgcagacaa gttccaggac agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtggcctg acatctgagg acacggccgt gtattactgt gcgacccacg
      421 gagggtatag cgacatctgg aactccctat atcacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000750             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:23357:22441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000750
VERSION     KCXD01000750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:23357:22441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59232.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          131 c          139 g          104 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgggtctatc agaagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaagt tgagcgctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000751             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13159:11948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000751
VERSION     KCXD01000751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13159:11948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..348
     V_segment       6..278
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59233.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       284..293
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..348
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           77 a           88 c          106 g           79 t
ORIGIN      
        1 acatgggggg aggcttggtc cagcctggag ggtctctgag actctcctgt gtagcctctg
       61 gattcagctt cagaagttac gaaatgagtt gggtccgcca ggctccggga aaggggctgg
      121 agtgggtctc atatattagt cacactggtg aaaccatata ccacgctgac tccgtgaagg
      181 gccgattcac catctccaga gacaacgcca agaattcgct gtctctgcaa atgagcagcc
      241 tgagagccga ggacacggcc gtgtattact gtactaggaa ccggaatact gtaatgattg
      301 ggtggttcga tgtctggggc ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000752             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14334:12208
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000752
VERSION     KCXD01000752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14334:12208"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59234.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          138 c          135 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000753             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17913:17674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000753
VERSION     KCXD01000753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17913:17674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59235.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       410..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          131 c          138 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagcctccgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgggtctat cagaagtagt tactgcagct ggatccgcca gaccccaggg aagggactgg
      241 agtggattgg gtatatctat gggagtgata gtagtaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtg ctccctgaag ttgagcgctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc gggtatagaa gtggttgcct
      421 acagcattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000754             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9440:13964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000754
VERSION     KCXD01000754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9440:13964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59236.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       440..445
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          108 a          111 c          154 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatgt
      121 taagaggtgt ccagtgtgag gtgcagatgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tttggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcatatgatg
      301 aaattacgaa atactacgca gactctgcga aggaccgatt caccatctcc agagacaatt
      361 ccaagaatgt ggtatatctt caaatgaaca gcctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag aggggatttt ggtaatggcg tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc tgcc
//
LOCUS       KCXD01000755             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14784:14249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000755
VERSION     KCXD01000755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14784:14249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59237.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       426..434
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           97 a          141 c          144 g          113 t
ORIGIN      
        1 acatggggag ggtcctgctc acatgggaaa tgctctctga gagtcatgga catcctgtgc
       61 aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc agttgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 ctctcctgca ctgtctctgg tggctccttc agtggttact actggagctg gatccgccag
      241 cccccaggga aggggctgga gtggattggg tttatcggtg gtggtagtgg gagcaccgaa
      301 tacaacccct ccctcaaaag tcgagtcacc atttcaagag acacgtccaa aaatcaattc
      361 tccctgaagc tggcctctat ggccgccgcg gacacggccg tttatttctg tgccagagat
      421 gcgggagtgg gagccacaat cctttactac tatgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000756             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:27456:7608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000756
VERSION     KCXD01000756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:27456:7608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59238.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          133 c          137 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atatttggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaggctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000757             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22091:13843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000757
VERSION     KCXD01000757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22091:13843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59239.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           82 a          145 c          137 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctccttca gcggttactc ctggagctgg gtccgccagc ccccaggcaa gggtctggag
      241 tggattggac atgtcagtgg tagtagtggg agcgccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag cgccagttct ccctgaggct gatttctgtg
      361 accgccgcgg acacggccgt ctatcactgt gcgagagtcc ggggcgttac tatccactac
      421 tttgattact ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01000758             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16143:9616
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000758
VERSION     KCXD01000758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16143:9616"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59240.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          110 a          134 c          157 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acctggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gcagctatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtagt aatagatatt atgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg agacctgagg acacggccgt
      421 gtattactgt gcgtcgaacc tacgtggaaa cacctacact tactggcggt cctttgactc
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000759             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14687:19778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000759
VERSION     KCXD01000759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14687:19778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59241.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          139 c          152 g          104 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgccctctc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaggaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggttgggagg tgttgatcct gcaaatggtg aggtaataca
      301 cgcagatagt tttcagggca gagtcaccat gaccgaggac acgtctacac tcacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagagggcg
      421 gttcggtagc agcgtctggt ccaatctcgt ctatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000760             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17994:5164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000760
VERSION     KCXD01000760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17994:5164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59242.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       443..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          114 c          156 g          115 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggagac ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcgg cctctggatt caccttcaga acctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcggtt atatcgaatg
      301 atgaaactaa caaatactac ggagactctg tgaagggccg attcagcatc tccagagaca
      361 attcgaagaa catgctatat cttcaaatga acaccctgaa attggaggac acggccgtgt
      421 attactgtgc gacagatgcg tttggtagtg ggattgacca ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000761             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18340:15997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000761
VERSION     KCXD01000761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18340:15997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    14..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        14..359
     V_segment       14..303
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <296..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59243.1"
                     /translation="CANGMSGLDYW"
     D_segment       304..308
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       318..359
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           77 a           92 c          114 g           78 t
ORIGIN      
        1 acatgggcag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa agcctggggg
       61 atccttgaga ctctcctgtg cagcctctgg attcaccttc agtcgctatg ctatgcactg
      121 ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattagta gtggtggtaa
      181 cacatacctc gcagactccg tgaagggccg attcaccatc tccagagacg actcaaagaa
      241 cacagtctcc ttgaaaatga acagtctgag acctgaagac acggccgcgt attactgtgc
      301 gaatgggatg tcagggcttg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      361 c
//
LOCUS       KCXD01000762             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18706:15512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000762
VERSION     KCXD01000762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18706:15512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59244.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       448..455
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          121 c          157 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcacc tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gacgacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atatttcgac ttctggggcc agggcgcact
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000763             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10630:16638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000763
VERSION     KCXD01000763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10630:16638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59245.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       418..429
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          139 c          138 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aagaaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga gatctgagga cacggccgtc tattactgtg cgattggccc tagtggcagc
      421 tggaacgact ggtccttcga catttgggga cctggcaccc caatcaccgt ctcctcagcc
//
LOCUS       KCXD01000764             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8132:2754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000764
VERSION     KCXD01000764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8132:2754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59246.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          103 a          116 c          164 g          120 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg gttcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctcc ggtattaata
      301 gtggtgggga tactacatac tacgtagact ccgtgaaggg ccgattcacc atgtccagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggatttctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01000765             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7880:3795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000765
VERSION     KCXD01000765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7880:3795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59247.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          124 c          156 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatact
      241 ggatgaactg ggtccgccag gctccagaga aggggctggt gtgggtctca ggtattaata
      301 gtggtgggga tagcacacac tacgcagact ccgtgaaggg tcgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct tagagcggag gacacggcca
      421 tatattactg tgcgaacgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000766             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18682:14948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000766
VERSION     KCXD01000766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18682:14948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59248.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          119 c          151 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tatgatgaga ctaagaaata ctacgcagac tctgtgaagg gccgattcac catcttcaga
      361 gacaattcca aaaacatgct atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000767             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13082:7160
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000767
VERSION     KCXD01000767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13082:7160"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..345
     V_segment       1..269
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59249.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       277..284
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..345
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           72 a           94 c           97 g           84 t
ORIGIN      
        1 gactggtgaa gccttcagag accctgtccc tcatatgcgc tgtctctgga ggctctatca
       61 gcggtggtta tgactggagc tggatccgcc agcccccagg gaggggactg gagtggattg
      121 ggtatatcta tggtagtcgt gggggcgcca cctacaaccc gtccctcaag aatcgagtca
      181 ccatctcaaa agacacgtcc aagaaccagt tgtccctgaa gctgaactct gtgaccgccg
      241 cggacacggc cgtatattat tgtgcgagac agtgttgtta ctatgatgac tttttagact
      301 actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000768             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18591:8131
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000768
VERSION     KCXD01000768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18591:8131"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59250.1"
                     /translation="CASGRTHWMELAALMGGLDSW"
     D_segment       417..422
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>504
                     /gene="IGHG"
BASE COUNT          112 a          137 c          152 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gagatgaaga agcctggggc ctctgtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagtttt ccatgcactg ggtgcgactg
      241 gcccctggaa aaggacttga gtggatggga ggtgttgatc ctctatctgg tgacataata
      301 cacgcagaaa agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tctattactg tgcgagtggg
      421 aggacacatt ggatggagtt ggcggcctta atgggcggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtcttgtc agcc
//
LOCUS       KCXD01000769             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4899:7248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000769
VERSION     KCXD01000769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4899:7248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59251.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           89 a          134 c          136 g          102 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctggg caagaacatg aagcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagtagtggt tatggctgga gctggatccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtctc tatgatagta gtgggaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca atagacacgt ccaagaacca gttctccctg aagctgaggt
      361 ctatgaccgc cgcggacacg gccgtgtatt actgtgcgcg atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000770             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22078:15984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000770
VERSION     KCXD01000770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22078:15984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..378
     V_segment       24..317
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59252.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       319..323
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       332..378
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           82 a           88 c          119 g           91 t
ORIGIN      
        1 acatgggaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
       61 agcctgggga gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctctg
      121 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      181 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      241 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      301 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      361 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000771             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14721:10261
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000771
VERSION     KCXD01000771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14721:10261"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59253.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           96 a          145 c          147 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct agctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagtaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000772             336 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7745:6434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000772
VERSION     KCXD01000772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 336)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 336)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7745:6434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..333
     V_segment       7..273
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <265..>303
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59254.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       277..292
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>336
                     /gene="IGHG"
BASE COUNT           80 a           99 c           87 g           70 t
ORIGIN      
        1 acatgggagg tgaaaaggcc cggggagtct ctgaggatct cctgtcagac ctctggatac
       61 aactttccca gcagctggat cacctgggtg cgccagatgc ccgggaaagg cctggagtgg
      121 atggggacca tctatcctgc tgattctaat gccaaataca acccgtcctt ccaaggccac
      181 gtcactatct cagtcgacaa gtccatcagc accacctact tgcagtggag caacctgaag
      241 gcctcggaca ccgccacgta ttactgtgcc aaaacctact atagtggtag tttggaatac
      301 tggggccagg gagtcctggt caccgtctcc tcaacc
//
LOCUS       KCXD01000773             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:24286:10018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000773
VERSION     KCXD01000773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:24286:10018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59255.1"
                     /translation="CARWGTPFDYW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           92 a          133 c          131 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcttgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 agctccatca acagtggtta tgcctggagc tggatccgcc agcccccaga gaaggggctg
      241 gagtggattg ggcatatcta tgatagtagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgagatct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgagat gggggacccc ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000774             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19056:14127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000774
VERSION     KCXD01000774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19056:14127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59256.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          111 a          132 c          157 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtagt aatagatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg agacctgagg acacggccgt
      421 gtattactgt gcgtcgaacc tacgtggaaa cacctacact tactggcggt cctttgacta
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000775             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5946:3397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000775
VERSION     KCXD01000775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5946:3397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59257.1"
                     /translation="CATHGGYSDIWNSLYHGFDSW"
     D_segment       422..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          121 a          147 c          138 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca acagccaccg gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga aattaagaag cctggggcct cagtgatggt
      181 ctcctgccag gtttccggat acaccgtcac cgaaatttcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgctcct gaaaaaaatg agttaataca
      301 cgcagacaag ttccaggaca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtggcctga catctgagga cacggccgtg tattactgtg cgacccacgg
      421 agggtatagc gacatctgga actccctata tcacggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000776             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23268:3908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000776
VERSION     KCXD01000776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23268:3908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59258.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       414..423
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          144 c          137 g           99 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agtcctcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc ggtagttact ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gaaatagcgg tagtacctac tacagcccct ccctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccaccac tccctgaagc tgaactctgt
      361 gaccaccgcg gacacggccg tgtatttctg tgcgaacgtc ttaggcccct ggggcagctg
      421 gtcacactac tttgagtact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000777             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21125:3176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000777
VERSION     KCXD01000777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21125:3176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59259.1"
                     /translation="CAREYCTNTDCAGFFDSW"
     D_segment       420..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          130 c          141 g          111 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg caaggcttct ggatttacct tcgacaacta tggaatcaac tgggtgcggc
      241 aggcccctgg acaagggctt gagtggatgg gagtggtcat cccccttgtt ggtattatta
      301 attatgcaga gaacttccag ggcagagtaa cgattaacgc ggacacgtcc ataaacacag
      361 ccttcatgga gttcaggagc ctgagatctg acgacacggc catttatttc tgtgcgagag
      421 aatactgtac aaacactgat tgcgccgggt tctttgactc ctggggccag ggagtcatgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000778             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:25032:5797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000778
VERSION     KCXD01000778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:25032:5797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59260.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          141 c          152 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgagatg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gtgaaataat
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgagatctga ggacacggcc gtgtattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccagcct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01000779             354 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27575:7063
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000779
VERSION     KCXD01000779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 354)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 354)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27575:7063"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..352
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..352
     V_segment       7..277
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>321
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59261.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       291..297
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..352
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        353..>354
                     /gene="IGHG"
BASE COUNT           90 a           90 c          101 g           73 t
ORIGIN      
        1 acatgggggg ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg caaggtttcc
       61 ggatacatct taaccgaatt atccatgcac tgggtgcgac aggcccctgg agaagggctt
      121 gagtggatgg gaagtgttga tcctcaatat ggtgaaatga tagacgcaga gaaattccag
      181 ggcagagtca ccatgaccga ggacacgtct acagacacag cctacatgga actgagcagt
      241 ctgagatctg aggacacggc cgtatattac tgtgcgacat catccagcgg cacctggcta
      301 tactggtact tcgatatctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01000780             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5097:12039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000780
VERSION     KCXD01000780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5097:12039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59262.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       405..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..472
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          104 a          143 c          132 g           95 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccttctgg tgcagtctgg ggctgaggtg atgcagcccg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacac cttcaccgaa ttgtccatgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtgggt gggaagtgtt gatcctgtat atggtgaaat gatgttccag
      301 ggcagagtca ccatgaccga ggacacgtct acagacacag cctacatgga gctgagcagc
      361 ctgacatctg acgacacggc cgtctattac tgtgcgattg gccctagcgg cagttggaac
      421 cactggtcct tcgatatctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01000781             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12294:14690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000781
VERSION     KCXD01000781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12294:14690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59263.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..451
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          123 c          148 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgct
      121 gctattttaa gaggtgtcca gtgtgaggtc cacctggtgg aatctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttccttt
      241 ggcatgcact gggtccgcca ggcaccgggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatggaa ctaacaaata ctacgcagac tctttgaaag accgattcac catatccaga
      361 gacaactcca agaacatact atatcttcaa ctgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtgtatggc tcggggcttg actactgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01000782             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:9409:10765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000782
VERSION     KCXD01000782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:9409:10765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59264.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       435..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          125 c          156 g          116 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc cagaattccc aggtgtttct gttcggcgat
       61 cagcactaaa cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc
      121 ttttgaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgcgcag cctctggatt caacttcaat tactactaca
      241 ttaactgggt ccgccaggct ccagggaagg ggctggagtg gatctcaggt attgacagtg
      301 gtggacatag cacatactat gcggactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaagaa cacactgtat cttcaaatgg acagcctgag agctgaggac acggctgtct
      421 attactgtgc gagagtggtg ggtggtgccg caggatactt cgacttctgg ggccagggcg
      481 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000783             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8974:16083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000783
VERSION     KCXD01000783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8974:16083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    154..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        154..517
     V_segment       154..447
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <439..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59265.1"
                     /translation="CARALDLFGYYGLDSW"
     D_segment       463..469
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..517
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          125 a          137 c          151 g          106 t
ORIGIN      
        1 acatgggggg taaatacaga tctgtccttg tccagagagc atcacacaac aaccacatcc
       61 ctcccctaca gaggccccag agcatagcac ctcaccatgg cctggacctg gaggatcctc
      121 ctgttggtgg cagcagctac aggcgcccat tatgaggtcc agctggtgca gtctggggct
      181 gaggtgaaga agcctggggc ctcagtgaag gtctcctgta aggtttccgg aaacaccgtc
      241 accgagctat ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtggatggga
      301 agtgttgatc ctaaaaatgg tgaaataata ctcgcagaga agttccaggg cagagtcacc
      361 atgaccgagg acacgtctac agacacagcc tacatggagc tgagcagcct gagatctgag
      421 gacacggccg tgtattattg tgcgagagcc cttgacttat tcggatatta cggtctggat
      481 tcttggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000784             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23206:11942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000784
VERSION     KCXD01000784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23206:11942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..472
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59266.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       400..417
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          135 c          135 g          108 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcggtgt ctctggtggc
      181 tccttcagcg gttactattg gagctggatc cgccagtccc cagggaaggg gctggagtgg
      241 attgggtata tcagtgctag tagtgggagt accgactaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaattac catttctccc tgaagctgac ctctgtgacc
      361 gccgcggaca cggccgtata ttactgtgcg agagagaagt actatagtgg tagttataaa
      421 cacaactggt tcgatgtctg gggcccggga gtccaggtca ccgtctcctc agcc
//
LOCUS       KCXD01000785             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:6237:12702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000785
VERSION     KCXD01000785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:6237:12702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59267.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          125 c          153 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttaat ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcagctatta acgctggtgg
      301 cgataccaca tactatggag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagct gaggacacgg ctgtctattt
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcccc gtctcctcag cc
//
LOCUS       KCXD01000786             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:25791:14939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000786
VERSION     KCXD01000786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:25791:14939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..510
     V_segment       135..428
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59268.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       449..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          101 a          126 c          158 g          127 t
ORIGIN      
        1 acatggggtg agacaggagc cttagccctg gattccaaga acttccactt tgggatcagc
       61 tctgaacaca gaggaccatg gagttggggc tgagctgggt tttccttgct gcttttttaa
      121 aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg ggccttggtc cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt tggtgattgt ggcatgcact
      241 gggtccgcca ggctccggga aagggactgg agtgggtctc atctattagt aagactggtg
      301 aaaccgaata ctacactgac tccgtgaagg gccgattcgc catttccaga aacaacgcca
      361 agaactcgct gtctctggaa atgagcagcc tgagagccga ggacacggcc gtgtattact
      421 gcactagaat ttgttgtccc cgtgatttta gcagcgactg tcactggttc gatgtctggg
      481 gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000787             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11702:8682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000787
VERSION     KCXD01000787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11702:8682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..519
     V_segment       144..437
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59269.1"
                     /translation="CARERFGGIGVIIYSWVDFW"
     D_segment       455..466
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..519
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          108 a          126 c          166 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtatt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttcttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctgaga ctctcctgcg cagcctccgg attcaccttc agtgacttct
      241 acatggactg ggtccgccag gctccaggga aggggctgga gtgggtctca cgtattaatc
      301 atgacggtgg taacacatgg tacgcagact ccgtgagggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tagacaggct gagacctgag gacacagccg
      421 tgtatttctg tgcgagagag cggtttgggg gaattggggt gattatctac agctgggtcg
      481 atttctgggg cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000788             413 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:26422:21225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000788
VERSION     KCXD01000788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 413)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 413)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:26422:21225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    240..411
                     /note="immunoglobulin heavy chain variable region"
     V_region        240..411
     V_segment       240..350
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <342..>380
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59270.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       359..365
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       372..411
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        412..>413
                     /gene="IGHG"
BASE COUNT           94 a           95 c          123 g          101 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 acgctgtgaa ggaccgattc accatctcca gagacaattc caagaacatg ctatatcttc
      301 aaatgaataa cctgaaaatg gaggacacgg ccgtgtatta ctgtgggaga gatgataatg
      361 gggtgcttat cgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000789             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17866:20818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000789
VERSION     KCXD01000789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17866:20818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59271.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       417..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          140 c          135 g          104 t
ORIGIN      
        1 acatgggagc acaaaacaac cacatccctc ctctaaagaa gcccctggga gcacagctca
       61 tcaccatgga ctggacctgg aggctcctct ttgtggtggc agcagctgca ggtgtccagt
      121 cccaggtccg cctggtgcag tccgggactg aggtgaagaa gcctggggcc tcagtgaaga
      181 tttcctgcgg ggcttctgga ttcaccctcg acacctatgg tatcaactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag tgatcatccc ccttattggt atcatcaact
      301 acgcagagaa ctctcagggc agactcacaa taaccgcgaa cacgtccaca aatacagcct
      361 atatggaact gagcagtctg agatctgagg acacggccat ctattactgt gcgagagaat
      421 actgtacttc tagtacttgc gccgggttcc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000790             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12799:17683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000790
VERSION     KCXD01000790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12799:17683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    72..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        72..426
     V_segment       72..365
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59272.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       378..384
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       385..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           99 a           95 c          127 g          107 t
ORIGIN      
        1 acatgggact caccatgaag tttgggctga gctgggtttt ccttgttgct gttttaagag
       61 gtgtccagtg tgaggtgcag ctggtggagt ctggaggaga cttggttcag cctggggggt
      121 ccctgagact ctcctgtgca gcctctggat tcaccttcag taactatggc atacactggg
      181 tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtct gatgcaagta
      241 agacatacta cgcaaactct gtgaaggacc gattcaccat attaagagac aattccaaga
      301 acatgctata tcttcaaatg aacaacctga aattggagga cacggccgtc tattactgtg
      361 cgagagacga tatgggaagt ggctttgact actggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01000791             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10424:10921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000791
VERSION     KCXD01000791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10424:10921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59273.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          122 a          140 c          136 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aagtccaagg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatcg
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcgtcag cc
//
LOCUS       KCXD01000792             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21564:16803
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000792
VERSION     KCXD01000792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21564:16803"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59274.1"
                     /translation="CAKWELEQPSDDW"
     D_segment       401..410
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           93 a          141 c          133 g           92 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgcg gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcacattctg gtggagctgg atccgccagc ccccagggaa ggcactggag
      241 tggattggag agatcaatgg tgatagtggg agaacccact acaacccctc cctcaaaagc
      301 cgactcacca tttcaaaaga cgcgtccaag aaccagttct ccctggagct gacctctgtg
      361 accgccgcgg acacggccgt ctattactgt gcaaaatggg agctggaaca gccgtcagac
      421 gactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000793             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6810:2941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000793
VERSION     KCXD01000793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6810:2941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59275.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          116 c          150 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcttccact gggtccgcca ggctccaggg aaggggctgg agtgggtgtc agttatttcg
      301 aatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga
      361 gacaattcca tgaacatgct atttcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000794             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12793:7223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000794
VERSION     KCXD01000794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12793:7223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..492
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59276.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       423..436
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>498
                     /gene="IGHG"
BASE COUNT          116 a          143 c          143 g           96 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccacctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacac cgtcaccgat ttatccattc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggagttgtt aatcctgtaa atggagaaat gatacacgca
      301 gagaagttcc aggccagagt caccatgacc gaggacacgt ctacagacac agcctacatg
      361 gagttggtca gcctgacatc tgaggacacg gccatctatt actgtgcgac agggaggatc
      421 ggtagcagcg tctggtccag cctcttcaac ggcttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct ccgcagcc
//
LOCUS       KCXD01000795             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18531:4298
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000795
VERSION     KCXD01000795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18531:4298"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59277.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          114 a          142 c          128 g           93 t
ORIGIN      
        1 acatgggatc acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt gttcatcctg aatatggtaa agtagactac
      301 acacagaagt tccgagacag agtcaccatc accgcggaca tgtcgacaga gacagcctac
      361 atggagctta gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtttc ctcagcc
//
LOCUS       KCXD01000796             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24197:6594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000796
VERSION     KCXD01000796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24197:6594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59278.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       400..415
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           89 a          142 c          134 g          101 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtacct actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctctg gtggtggtgg gaacaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaagag acacgtccag gaaccagttc tccctgcagc tgaattatgt
      361 aaccgccgcg gacacggccg tgtattactg tgccagaact agcggtggct ggtcccccta
      421 ctttgactat tggggccggg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000797             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18207:9908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000797
VERSION     KCXD01000797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18207:9908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..501
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59279.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       421..434
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>507
                     /gene="IGHG"
BASE COUNT          114 a          138 c          147 g          108 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctcttcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgggtg gataggaggg atcatccctc ttgttggtat gacaaactac
      301 gaacaggagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      361 atggaactga gcagcctgag atcggaggac acggccgtct actattgtgc gacaggggta
      421 tattaccagg atgaaaacgg ttatttttat gtcggcgggg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01000798             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21007:18211
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000798
VERSION     KCXD01000798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21007:18211"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..395
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59280.1"
                     /translation="CTTWTTGYNYYFAYFDSW"
     D_segment       415..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          142 c          132 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga gcggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc gacactaaca ggtggagttg gatccgccag tccccaggga agggactgga
      241 gtggattgga tacatcgatg gcacttctac gcgcaccgac tacaccccct ccctcaaagg
      301 tcgagtcacc atttcaaaag acacgtccag gaaccagttc tccttgaggc tgaattctgt
      361 gagcgccgca gacacggccg tgtattactg tacgacttgg acgactgggt ataattatta
      421 cttcgcctac tttgacagct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000799             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:23045:10932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000799
VERSION     KCXD01000799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:23045:10932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59281.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacaagtg
      241 gcatgcactg ggtccgccag actccaggga aggggctgga gtgggtggct gttaaatcgc
      301 acgatggaaa taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gatacggcca
      421 tttattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000800             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20282:12817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000800
VERSION     KCXD01000800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20282:12817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59282.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       422..429
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          139 c          152 g          108 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctataga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacacgttc agcatctatg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcatcc ctcttgttgg tataacaaac
      301 tacgctcaga ggttccgggg cagagtcacg atttccgcgg acacgtccac aagcacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagggga
      421 gattgtactg atactgactg ctcttccgcg gggggcgcct ttgatttctg gggccaaggg
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01000801             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19901:18890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000801
VERSION     KCXD01000801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19901:18890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59283.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgagctcca ggtggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01000802             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13703:18474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000802
VERSION     KCXD01000802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13703:18474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59284.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       407..419
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           91 a          141 c          128 g          110 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 ggtccatcag cagttaccac tggagctgga tccgccagcc ccctgggaag ggactggagt
      241 ggattggaca tatctctctt agtggtggaa gaaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaaactg agttctgtga
      361 cccccgcgga cacggccgtc tattactgtg cgagagatca ggattcttac gtttactatc
      421 gcttctttga cttctggggc cagggagtcc tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01000803             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20656:18266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000803
VERSION     KCXD01000803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20656:18266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59285.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          107 a          144 c          134 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcaacaggc
      241 cccaggaaga ggccttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaga tctgaggaca cggccgtata ttactgtgcg atcggcccta gcggcagttg
      421 gaacgcctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000804             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19433:16227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000804
VERSION     KCXD01000804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19433:16227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59286.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       259..264
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           79 a           79 c           84 g           79 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaatttt
       61 ggcatacact gggtccgcca ggctcccggg aagggtctgg agtgggtagc agttatctcc
      121 catgatgaga ataatatata ttacgcagac tccgtgaagg accgattcac catctccaga
      181 gacaattcca agaacaacgt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtgttttact gtgtgagaga tacattcggt tcaggatttg actactgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000805             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16120:11622
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000805
VERSION     KCXD01000805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16120:11622"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59287.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       426..432
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          112 a          138 c          152 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gcaagtgatg aagtaataca
      301 cgcagatggt ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggggctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagagggag
      421 gttcggtagt agcgtctggt ccaatctcgt ctatggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000806             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:15288:11130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000806
VERSION     KCXD01000806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:15288:11130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59288.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          124 a          140 c          134 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga gaagggcttg agtggatggg aagtgttgat cctaaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagtc tgagatctga ggacacggcc gtatattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000807             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19702:14576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000807
VERSION     KCXD01000807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19702:14576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59289.1"
                     /translation="CATHGGYSDIWTSLYNGLDSW"
     D_segment       424..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          121 a          147 c          140 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagccac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagttaaga ggcctggggc ctcagtgatg
      181 gtctcctgcc aggtttccgg gtacaccgtc accgaaatat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgctc ctgaaaaaaa tgaattaata
      301 cacgcagaca agttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtggcct tacatctgag gacacggccg tgtattactg tgcgacccac
      421 ggagggtata gcgacatctg gacctcccta tataacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000808             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5825:3572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000808
VERSION     KCXD01000808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5825:3572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59290.1"
                     /translation="CAREGISASGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          136 c          144 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaaa gaccagttct ccctgaggct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc gtcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000809             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17869:15269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000809
VERSION     KCXD01000809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17869:15269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59291.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          114 a          114 c          155 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaact aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 ctattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01000810             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22514:13480
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000810
VERSION     KCXD01000810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22514:13480"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59292.1"
                     /translation="CTRGSYSGSYYFNRFDVW"
     D_segment       403..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          138 c          136 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctatcagc agtagtacct ggtggaactg gatccgccag cccccaggga aaggcctgga
      241 gtggattggg tatataagtg gtgatagtgg tagcacctac tacaacccct ccctcaagag
      301 tcgaatcacc atttcaacag acacgtccac gagccagttc tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tacgagaggt tcctatagtg gtagttatta
      421 cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000811             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16817:22480
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000811
VERSION     KCXD01000811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16817:22480"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59293.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       428..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..487
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>493
                     /gene="IGHG"
BASE COUNT          115 a          141 c          141 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atccactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggctgggagg tgttgatctt gtatatgatg aaataataca
      301 cgcagagaag ttccaaggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctga gatctgagga cacggccgtg tattactgtg cggcgggcct
      421 tgggggatat ttactgctca ctgaatacct cgagttctgg ggccagggcg ccctggtcac
      481 cgtctccacc gcc
//
LOCUS       KCXD01000812             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21140:4092
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000812
VERSION     KCXD01000812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21140:4092"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59294.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       445..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          122 c          147 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttcctttgg
      241 catgcactgg gtccgccagg caccggggaa ggggctggag tgggtggcag ttttatcgtc
      301 tgatggaact aacaaatact acgcagactc tttgaaagac cgattcacca tatccagaga
      361 caactccaag aacatactat atcttcaact gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctc ggggcttgac tactggggcc agggagtcct
      481 gctcatcgtc tcctcagcc
//
LOCUS       KCXD01000813             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:11989:9797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000813
VERSION     KCXD01000813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:11989:9797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..329
     V_segment       7..268
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <260..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59295.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       278..283
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           76 a           80 c           95 g           80 t
ORIGIN      
        1 acatggggtt cagcctgggg ggtccctgag actctcctgt gtagcctctg gattcacctt
       61 cagaaacttt ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc
      121 tgttatctcg tatgatgaaa ataccaaata ctacgcagac tctgtgaagg accgattcac
      181 catctccaga gacaattcca agaatatgct atatcttcaa atgaacaacc tgaaattggg
      241 ggacacggcc gtgtattatt gtgtgcgaga tgtcagggga acggggtttg acttctgggg
      301 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000814             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17156:11112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000814
VERSION     KCXD01000814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17156:11112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..469
     V_segment       106..402
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59296.1"
                     /translation="CARWGDSQSIYYFDYW"
     D_segment       403..410
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>474
                     /gene="IGHG"
BASE COUNT           95 a          133 c          135 g          111 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacatg cgctgtctct
      181 ggtggctcta ttagcagtag taactggtgg aactggatcc gccagccccc agggaaaggg
      241 ctggagtgga ttgggtatat cagtggtgct agtggtagta ccgactatca cccctccctc
      301 aagagtcgag tcaccatttc aacagacacg tccaagaacc agtttaccct gaagttgagc
      361 tctgtgaccg ccgcggacac ggccgtgtat tactgtgcga gatggggtga ctcccagtcc
      421 atttactact ttgactactg gggccaggga gtcctggtct ccgtctcctt agcc
//
LOCUS       KCXD01000815             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:3124:18505
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000815
VERSION     KCXD01000815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:3124:18505"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59297.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          139 c          139 g           96 t
ORIGIN      
        1 acatggggga tccaacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatggtgt
      301 tccagggcag agtcaccatg accgaggaca cgtctataga cacagcctac atggagttga
      361 gcagcctgag atctgaggac acggccgtgt attactgcgc gattggccct agcggcaact
      421 ggaacggctg gtccttcgat atctggggac ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000816             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13036:9499
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000816
VERSION     KCXD01000816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13036:9499"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    156..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        156..522
     V_segment       156..445
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59298.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       463..471
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..522
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT          118 a          120 c          155 g          131 t
ORIGIN      
        1 acatggggca gagtacatgg ggtctgggag aggagcccag ccctgggatt cccaggtgtt
       61 ttcattcaga gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg
      121 ttttccttgt tgctatatta aaaggtgtcc agtgtgtggc gcagctggtg gaatctgggg
      181 gaggcttggt acagcctggg gcgtccctga gactctcctg tgcggcctct gaattcacct
      241 tcagcagcta tgacatgcac tgggttcgcc aggctccagg gaagggtctg gagtgggtat
      301 caggtattaa cattggcggt gacacatact acccagactc tgtgaagggt cgattcacta
      361 tctccagaga caatgccaag aactccttgt atcttcaaat gaacagcctg agagttgagg
      421 acactgctgt gtatttttgt gcaaggggga tagataacta ccactatagt gatacggact
      481 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000817             283 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21714:5724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000817
VERSION     KCXD01000817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 283)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 283)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21714:5724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..281
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..281
     V_segment       8..220
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <212..>250
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59299.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       231..240
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       241..281
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        282..>283
                     /gene="IGHG"
BASE COUNT           69 a           69 c           79 g           66 t
ORIGIN      
        1 acatgggacc ttcagtaatt ttggcatcca ctgggtccgc caggctccag ggaagggcct
       61 ggagtgggtg gcagttatat cgtctgatga aagtaagaaa tactatgcag actctgtgaa
      121 ggaccgattc accatctcca gagacaattc caagaacatg gtttatcttc agatgaacaa
      181 cctgaagttg gacgacacgg ccgtctatta ctgtgcgaga gacgcatttg gcagcggctg
      241 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000818             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7651:5471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000818
VERSION     KCXD01000818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7651:5471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59300.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          115 c          153 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc actcggtgat
       61 cagcacagag cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttac
      121 ttttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctaagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatggaagt agaaaatact acccagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccgag gccaatgtat atcttcaaat gaataacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatg cgtatggttc cggtttggat tcctggggcc aaggggtcgt
      481 cgtcgccgtc tcctcagcc
//
LOCUS       KCXD01000819             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14506:6099
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000819
VERSION     KCXD01000819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14506:6099"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59301.1"
                     /translation="CARSSSGTWLYWFFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          152 c          134 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgcccg
      121 ctctgaggtc cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattc tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgcatatg gtgaaatgac
      301 acacgcagat aacttccagg gcagactcac catgaccgag gacacgtcta cagacacggc
      361 ctacatggag ctgaccaccc tgacatctga ggacacggcc gtgtattact gtgcgagatc
      421 atccagcggc acctggctat actggttctt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01000820             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:7841:11748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000820
VERSION     KCXD01000820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:7841:11748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59302.1"
                     /translation="CASGPSGNWNGWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          143 c          140 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacgg
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatttgg tgaaatgatc
      301 gagacagaga acttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gactcggccg tgtattactg tgcgagtggc
      421 cctagcggca actggaacgg ctggtatttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01000821             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5167:11563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000821
VERSION     KCXD01000821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5167:11563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59303.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          118 c          150 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaga aaagaaaatc tacgcagact ctgtgaagga ccgaatcacc atttccagag
      361 acgattccaa gaacacgcta tatcttcaaa taaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000822             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13146:4504
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000822
VERSION     KCXD01000822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13146:4504"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..461
     V_segment       98..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59304.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       395..402
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           93 a          135 c          127 g          108 t
ORIGIN      
        1 acatggggct ctgagagtca tggacctcct gtgcaagaac atgaagcacc tgtggttctt
       61 ccttctcctg gtggcagctc ccagatgggt cctgtcccag gtgcggctgc aggagtcggg
      121 cccaggactg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct ctggtgactc
      181 catcagcagt agctactgga actgggtccg ccagccccca gggaagggac tggaatggat
      241 tgggtatatc tctggtgctt atgggagcac caactacaac ccctctctca agagtcgagt
      301 caccatttca ctagacacgt ccaagagcca cttttccctg aggctgagtt ctgtgaccgc
      361 cgcggacacc gccgtatatt actgtgtgag atatgaggat gaatccatta attaccactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000823             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13199:3604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000823
VERSION     KCXD01000823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13199:3604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59305.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          117 a          141 c          131 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagctc
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaagtaaagg ggcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga ggttttggtc ctgtgtatgg tgaaataata
      301 cacacagaga agttccaggg cagagtcact atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01000824             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:7003:16610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000824
VERSION     KCXD01000824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:7003:16610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59306.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       412..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           98 a          134 c          139 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggcta
      181 ctccgtcagc agtggttatt actactgggg ctggatccgt cagcccccag ggaaggggct
      241 ggagtggatt gggtatattg gtggtagtag tgggagcacc tactacaatc cctccctcaa
      301 gagtcgagtt accatttcaa aagacacgtc caagaaccag ttctccctga agctgaactc
      361 tgtgaccgcc gcggacacgg ccgtgtatca ctgtgcgaga catggaggtt tctatagtgc
      421 gactgataag tcaacatttg acaactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01000825             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:25719:10284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000825
VERSION     KCXD01000825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:25719:10284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59307.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       397..405
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          136 c          130 g          115 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgttca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaaa tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaactc ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggatcggtt atgtctatgg tgatagtggg aacaccgaat acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga ctcgtccaag aatcagtttt ccctgaagct gagttctgtg
      361 accgccgcgg acaccgccgt gtatcactgt gcgagataca gttacggttc caactacttc
      421 tttgggttct ttgactattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000826             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14531:13859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000826
VERSION     KCXD01000826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14531:13859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59308.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       426..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          132 c          146 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 cccaggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggtg aaataattgt
      301 cgcagagaat ttccaggaca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctgg aatctgagga cacggccgtg tattactgtg cgaaagggag
      421 gagtggtggt gtctggccga gctccttcga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000827             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21470:14550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000827
VERSION     KCXD01000827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21470:14550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..317
     V_segment       8..253
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59309.1"
                     /translation="CTGGAYANLDYW"
     D_segment       266..270
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           72 a           87 c           95 g           65 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaacta
       61 ctggatgaac tgggtccgcc agactccagg aaaggggctg gagtgggtct cagctattaa
      121 ttatgatggg ggtagcgcat actacgcaga ctccgtgaag ggccgattca ccatttccag
      181 agacaactca aagagtacgc tctccctgca aatgagcagc ctgagagcgg aggacacggc
      241 cgtatattac tgtacgggcg gggcatacgc taacctcgac tactggggcc agggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000828             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14005:4201
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000828
VERSION     KCXD01000828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14005:4201"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59310.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          140 c          137 g           99 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtctccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgacg gtttcctgcg
      181 gggcctctgg attcaccttc gacacccatg gaatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttattgg tatcacaaac tacgcaaaga
      301 actctcaggg cagagtcaca ataaccgcga acacgtccac aaacacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggcca tctattattg tgcgagagaa tactgtactt
      421 ctagtagttg cgccgggttc cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01000829             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20087:11887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000829
VERSION     KCXD01000829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20087:11887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59311.1"
                     /translation="CATGFGGSWTRFDYW"
     D_segment       409..414
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          133 c          134 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagt agtaactact ggagttggat ccgccaggcc ccagggaagg gactggaatg
      241 gattggatat atctttggta gtggcagtga caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaacaa tcagctctcc ctggagctga gctctgtgac
      361 cgccgcggac acggcccttt attattgtgc gaccgggttt ggtggcagtt ggaccagatt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000830             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9376:13731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000830
VERSION     KCXD01000830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9376:13731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59312.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          114 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtaaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000831             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17940:9565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000831
VERSION     KCXD01000831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17940:9565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59313.1"
                     /translation="CARGTGAILVYFDYW"
     D_segment       441..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          123 c          155 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtcctg tgtgagataa aactggtgga gtctgggggc gacttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcctc aggcactact
      241 atctgacctg ggtccgccag ggtccaggga aggggctgga gtggatctca ggtattaaca
      301 gtggtgggag tagcacatac tatgcagact ccgtgaagga cagattcacc atctccagag
      361 acaacgccaa gaacacactg tatcttcaaa tggacaacct gagagctgag gacacggctg
      421 tctattactg tgcgaggggg actggggcga ttcttgtgta ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000832             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:10617:13750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000832
VERSION     KCXD01000832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:10617:13750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59314.1"
                     /translation="CARDAFGSGLDYW"
     D_segment       448..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          118 c          150 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctctcttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatttcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgcttcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct taaattggag gacacggccg
      421 tgtattactg tgcgagagat gctttcggca gcgggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000833             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17943:7869
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000833
VERSION     KCXD01000833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17943:7869"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..485
     V_segment       138..425
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59315.1"
                     /translation="CTGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>491
                     /gene="IGHG"
BASE COUNT          108 a          129 c          151 g          103 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcagatgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcgc tactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagaatgggt ctcagctatt aatactgatg
      301 gggagaacac atactacgca gactccgtga agggccgatt ctccatctcc agagacaact
      361 caaagaccac actctccctg caaatgaaca gcctgagacc ggaggacacg gccgtatatt
      421 actgtacggg cggggcgtac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctccacagc c
//
LOCUS       KCXD01000834             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5228:7381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000834
VERSION     KCXD01000834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5228:7381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59316.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       407..428
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           95 a          142 c          134 g          116 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgcagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctatcagc agtactaaat ggtggagctg gatccgccag cccccaggga aagggctgga
      241 gtggattggg tatatcagtg gtagtagtgg taacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacgg acacgtccaa caaccagttt tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tttattattg tgcgagatcc caatcctatt gtagtgggct
      421 ttactgcttc ggctactact actttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000835             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14222:3221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000835
VERSION     KCXD01000835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14222:3221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59317.1"
                     /translation="CARVLYYDSGYSTNPYNRFDVW"
     D_segment       421..439
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          141 c          143 g          105 t
ORIGIN      
        1 acatggggac agaacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagcgacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctt
      181 tcctgcaagg cttctggata caccttcagc atctatgcca tcacttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggagga atcatccctc ttgttggtat aacaaacgac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagtttta
      421 tactatgata gtggttattc cacgaacccc tacaaccggt tcgatgtctg gggtccggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000836             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13330:13652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000836
VERSION     KCXD01000836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13330:13652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59318.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          109 c          157 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gatggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgt
      241 catgcactgg gtccgccagg ctccagggaa ggggctggac tgggtgacag ttatatcgta
      301 tgatggaagt acgaagtact atgtagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcgaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagagtag actgtagtgg tggtgtctgc tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cgtcagcc
//
LOCUS       KCXD01000837             409 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23710:11027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000837
VERSION     KCXD01000837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 409)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 409)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23710:11027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    47..407
                     /note="immunoglobulin heavy chain variable region"
     V_region        47..407
     V_segment       47..337
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <329..>376
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59319.1"
                     /translation="CVKGETAAAYYGLDSW"
     D_segment       344..349
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       356..407
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        408..>409
                     /gene="IGHG"
BASE COUNT           92 a           99 c          122 g           96 t
ORIGIN      
        1 acatgggggg gttttccttg ttgctatttt aagaggtgtc cagtgtgagg tgcagctggt
       61 ggagtctggg ggcggcttgg caaaacctgg gggatccctg agactctcct gtacagcctc
      121 tggattcacc ttcaatactt attctatgca ttgggtccgc caggctccag ggaaggggct
      181 ggagtgggtc tcagctgtta gtagtagtgg gagcacatac tacgcagact ccgtgagggg
      241 ccgatgcacc atctccagag acaactcaaa gaacataatc tccctgcaaa tgaacagcct
      301 gagaactgag gacacggccc tatattactg tgtgaaagga gaaacagctg cagcatacta
      361 cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01000838             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16630:12010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000838
VERSION     KCXD01000838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16630:12010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..454
     V_segment       94..381
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59320.1"
                     /translation="CMKYRYHSGSYNDYW"
     D_segment       398..411
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           97 a          129 c          134 g           96 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aggtgcagga gtcgggccca
      121 ggactggtga agccctcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccttc
      181 agtagttact ggtggaactg gatccgccag cccccaggga agggactgga gtggattggg
      241 gaggtcaatg gtgatagtgg gagcaccaac tacaacccct ccctcaagag tcgagtcacc
      301 atttcaaaag acgcgtccaa gaagcgggtc tccctgaagc tgaactctgt gaccgccgcg
      361 gacacggccg tatattactg tatgaaatat cgctatcata gtggtagtta taacgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000839             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10824:5868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000839
VERSION     KCXD01000839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10824:5868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..493
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59321.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       443..448
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          108 a          112 c          154 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 tgttaagagg tgtccagtgt gaggtgcaga tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt atctttggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcatatg
      301 atgaaattac gaaatactac gcagactctg cgaaggaccg attcaccatc tccagagaca
      361 attccaagaa tgtggtatat cttcaaatga acagcctgaa attggaggac acggccgtgt
      421 atttctgtgc gagaggggat tttggtaatg gcgtcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01000840             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14800:16045
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000840
VERSION     KCXD01000840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14800:16045"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59322.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       424..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           94 a          147 c          144 g          110 t
ORIGIN      
        1 acatggggtc tccctcaccg cacagctggg atctcagtgc ttccttttct gtcctccacc
       61 acgatggggt caactgccat cctcaccctc ctactggctg ttctccaagg agtctgtgcc
      121 gaggtgcagc tggtgcagtc tggagcagag gtgaaaaggc ccggggagtc tctgaagatc
      181 tcctgtaaga cttctggaga cacctctacc tactattgga tcagctgggt gcgccagatg
      241 cccgggaaag gcctggagtg gatgggggcg attgatcctg gtgattctga taccaaatat
      301 agtccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac
      361 ctgcagtgga gcagcctgaa ggcctcggac accgccacgt atttctgtgc gaaagggggg
      421 tggtggggtg attatccacc ctcagactgg ctcgatgtct ggggcccggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000841             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19134:16711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000841
VERSION     KCXD01000841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19134:16711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..420
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59323.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       422..428
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          138 c          144 g          100 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccacctggt gcagtctggg gctgaagtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaagtttc cggatacacc ttcaccgatt tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg atactgtatc tgatggagtg
      301 atatacgcag aaaacttcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtttatta ttgtgcgaga
      421 ggtgtgacag cagacgtctt cggtttcctc gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000842             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21712:12904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000842
VERSION     KCXD01000842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21712:12904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..463
     V_segment       94..390
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59324.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       406..413
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          100 a          136 c          128 g          101 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg aggctctgtc
      181 agcggtgttt atgactggag ctggatccgc cagcccccag ggaaggggct ggagtggatt
      241 ggctatatct atggtagtag tgggaacacc aactacaacc cgtccctcaa gaatcgagtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga aactgagctc tgtgaccgcc
      361 gcggacacgg ccgtatatta ctgtgcgaga cgcccagaaa acagttacta cttctactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000843             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9081:8779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000843
VERSION     KCXD01000843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9081:8779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59325.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       431..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          143 c          150 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccgctc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaatata
      301 cgcagagagg ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagt agcggctggt ccagcctctt caccggtttg gattcctggg gccgaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01000844             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23249:2491
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000844
VERSION     KCXD01000844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23249:2491"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59326.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       399..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          139 c          139 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctctggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatgagc agtcactact gcagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgg atctctggta gtggtgggag caccgactac accccctccc tcaagagtcg
      301 agtcaccctc tcaacagaca cgtccaagaa ggagatctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagaagac tatggtggta attattactt
      421 taaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000845             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14950:11146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000845
VERSION     KCXD01000845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14950:11146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59327.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           90 a          141 c          136 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaacttct gggcctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccaggtctcc ctgaaagtga cttctgtgac
      361 cgccgcggac acggccgttt attactgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcatc gtctcctcag cc
//
LOCUS       KCXD01000846             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19732:14543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000846
VERSION     KCXD01000846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19732:14543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..260
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59328.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       271..279
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           75 a           86 c           89 g           73 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcactgctt
       61 atggcatcca ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat
      121 cgtctgatgg aaataaccta tactacgcag actctctgaa ggaccgattc accatctcca
      181 gagacaattc caagaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg
      241 ccgtctatta ctgtgcgaga gattcatatg gcagcggctc cgactactgg ggccagggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000847             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20716:16825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000847
VERSION     KCXD01000847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20716:16825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59329.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       448..456
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          114 c          162 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gttattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcccgggg ggtcactgag actgtcctgt gcagcctctg gattcacctt cagtagctct
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg aatgggaggc acttatatct
      301 aatgatggaa gtaagaaata ttacgcagac tccgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct gtatcttcaa atgaacaacc tgaaattgga tgacacggcc
      421 gtgtattact gtgcgcgagt tggagagggt agtggtggtg cggaggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000848             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19607:7839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000848
VERSION     KCXD01000848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19607:7839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..360
     V_segment       4..279
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59330.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       295..302
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           83 a           91 c          102 g           86 t
ORIGIN      
        1 acatggggga gtctggggga ggcttggtac agcctggggc gtccctgaga ctctcctgtg
       61 cagcctctga attcaccttc agtggctatg acatgcactg ggttcgccag gctccaggga
      121 agggtctaga atgggtatca ggtattaaca ttggcggtga cccatactac ccagactctg
      181 tgaagggtcg attcaccatc tccagagaca acgccaagaa ctccttgtat cttcaaatga
      241 acaacctgag acctgaggac actgctgtgt attattgtgt gagggggatg gataactacc
      301 acttcagtaa tacggacttt gactactggg gccagggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01000849             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:27250:8453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000849
VERSION     KCXD01000849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:27250:8453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59331.1"
                     /translation="CVRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          110 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtga agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtctctgaga ctctcctgtg cagcttccgg attcaccttc agtttctatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcga
      301 atgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgtgagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000850             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8766:7403
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000850
VERSION     KCXD01000850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8766:7403"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..442
     V_segment       85..375
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59332.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       384..393
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           77 a          134 c          135 g           98 t
ORIGIN      
        1 acatgggggg acctcctgtg caagaacatg aagcacctgt ggttcttcct cctcctggtg
       61 gtagctccca gatgggtcct gtcccaggtg cagctgcagg agtcgggccc aggactggtg
      121 aagccttcgg agaccctggc cctcacctgc gctgtctctg gtggctccat cagtggttac
      181 tggtggggct ggatccgcca gtccccaggg agggggctgg aatggattgg atttttcggt
      241 ggtagtggtg ggaacaccta ctacaagtcc tccctccaga gtcgagtcac catttcagcc
      301 gacccgtcca agaaccagtt ctccctgata ctgacctctg tgaccgccgc ggacacggcc
      361 ctctattact gtgcgcgggg gaatatagca gcgactggca ttgactactg gggccaggga
      421 ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000851             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:27253:14708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000851
VERSION     KCXD01000851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:27253:14708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59333.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       436..447
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          116 c          152 g          117 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccattgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggt ctggagtggg tggcagttat gtcgcatgat
      301 ggaactaaga aattctacgc agactctgtg aaggaccgat tcaccatctc cagggacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgagat tggaggacgc ggccgtctat
      421 tattgtgcga gaggagacta cggtaacagc cttgacttct ggggccaggg agtcctgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000852             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19071:12469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000852
VERSION     KCXD01000852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19071:12469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59334.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       441..445
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          138 c          144 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gttttcggat acaccttcag cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgacact gtctctgacg gagtgatata
      301 cgcagagaac ttccagggca gagtcgccat gaccgaggac acgtctacag acacagccta
      361 catggaattg agcagcctga gatctgagga cacggccgtt tattactgtg cgagaggttt
      421 atcaccagac gtcttcggtt tcctcgggct tggctactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000853             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11142:14249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000853
VERSION     KCXD01000853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11142:14249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59335.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       442..454
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          121 c          151 g          123 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgttcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtacaactgg tggaatctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cctcagtaac tactggatgt
      241 actgggttcg ccaggcacca gggaaggggc tggagtggat ctcagctatt aacagtgttg
      301 gtgataccac atactatgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctatctatt
      421 actgtgcgag agttccgggc ctagtggtat ttaccggttc gcttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000854             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10351:17966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000854
VERSION     KCXD01000854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10351:17966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59336.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          123 a          139 c          133 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaataataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01000855             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14163:4894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000855
VERSION     KCXD01000855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14163:4894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59337.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          122 c          148 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga gtctggagga ggcttcattc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccctc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taggaaatac tacgcagact ctttgaaagc ccgattcacc atatccagag
      361 acaactccaa gaacatagta tatcttcaat tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01000856             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20310:21481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000856
VERSION     KCXD01000856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20310:21481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..499
     V_segment       127..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59338.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       426..440
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          143 c          143 g          103 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg tctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatccacc ttcaccgagt tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg ctcctctata tggtgaaatg
      301 atgcacgcag acaacttcca gggcagagtc accttgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctgagatct gacgacacgg ccgtgtatta ctgtgcgcgt
      421 gggcctatta caatttttgg cgtacttatt acggggcttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000857             337 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12550:15510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000857
VERSION     KCXD01000857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12550:15510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..335
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..335
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>304
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59339.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       270..286
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..335
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        336..>337
                     /gene="IGHG"
BASE COUNT           79 a           81 c           97 g           80 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagctt
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cacttatatc
      121 gtttgatgga actaagcagt actacgcaga ctctgtgaag gaccgattca ccatttccag
      181 agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg gggacacggc
      241 cgtgtattac tgtgcgagag ttagtggtca tacagagggt acagttgaat actttgacta
      301 ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000858             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13820:16466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000858
VERSION     KCXD01000858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13820:16466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59340.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          124 c          149 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ccattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtcccggaga ctctcctgtg cagcctccgg attcaccttc agtacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagaaattc tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000859             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:25113:15042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000859
VERSION     KCXD01000859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:25113:15042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..426
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59341.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       464..470
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          111 a          122 c          161 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcttga caaagccggg
      181 ggggtccctg agactctcct gtgcagcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgaatcg gtcatgatgg
      301 tggtagcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagaatgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gaggacacag ccgtatatta
      421 ctgtgccaga gagcggtttg ggggaattgg ggtaattatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01000860             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21285:17283
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000860
VERSION     KCXD01000860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21285:17283"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59342.1"
                     /translation="CSRADIVAAASFDLW"
     D_segment       426..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          117 a          138 c          126 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggttcagtc tggggctgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata taccttcact aactactaca tgcactgggt gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt ataatggtta caaatcggcc
      301 gcacagagtt tccagggcag agtcaccata agtgcggaca tgtccatgag cacaggctac
      361 atggaactaa ccagcctgag atctgaggac acagccgtgt attactgttc gagagcagac
      421 atagtagcgg ctgcctcctt tgacctctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000861             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15937:4713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000861
VERSION     KCXD01000861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15937:4713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59343.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          109 a          145 c          134 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaagtc cagctggtgc agtctggggc tgaggtgaag aagcttgggg cctcagtgag
      181 ggtctcctgc aggatttccg gatacacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctgtatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acttggaact
      361 gagcggcctg acttctgagg acacggccgt gtattactgt gcgactggcc ctaccggcac
      421 ctggaacgcc tggtacctcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01000862             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13408:11331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000862
VERSION     KCXD01000862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13408:11331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59344.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          111 c          150 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000863             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:23091:7883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000863
VERSION     KCXD01000863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:23091:7883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    132..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        132..486
     V_segment       132..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59345.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       435..440
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          109 a          113 c          149 g          117 t
ORIGIN      
        1 acatgggggg agcccagccc tggaagtcca cagtgttcca ttcggtgatc agcacagaac
       61 acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct attttgagag
      121 gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag cctggggggt
      181 ccctgagact ctcctgtgca gcctctggat tcaccttcat taactatggc attcactggg
      241 tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtat gatgaaacta
      301 agaaatacta cgcagactct gtgagggacc gattcaccat ctccagagac aattccaaaa
      361 acatggtata tcttcaaatg cacagcctga aattggagga cacggccgta tattactgtg
      421 cgagagatgt ccggggaacg gggtttgact tctggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01000864             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27257:10509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000864
VERSION     KCXD01000864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27257:10509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59346.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       445..450
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          108 a          113 c          156 g          121 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagagc acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgaa gcctctggat tcaccttcag tatttctggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt taaatcgttt
      301 gatggaacta agatatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccgtt
      421 tattactgtg tgagagatgc ctacgggagc ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000865             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:7254:5384
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000865
VERSION     KCXD01000865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:7254:5384"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59347.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          150 c          141 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aggggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaaca
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggact tgaccagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01000866             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11203:8245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000866
VERSION     KCXD01000866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11203:8245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59348.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          116 a          142 c          128 g           92 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttccggat acaccttaac cgaccactac ctacactggg tgcgacagac
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg aggagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000867             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8219:3157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000867
VERSION     KCXD01000867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8219:3157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..480
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59349.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       410..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>484
                     /gene="IGHG"
BASE COUNT          114 a          144 c          127 g           99 t
ORIGIN      
        1 ccatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt cccgtctaca ccttcgccga attgcccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggttt tgcttctata tatggtgaaa taatacatac
      301 agagagattc cagggcagag tcaccatgac agcggacacg tctatagaca cagcctacat
      361 ggaactcagc agcctgacat ctgaggacac ggccgtgtat tactgtgcgg cagctgatag
      421 tggttaccca ttttactact tcgatatctg gggccctggc accccaatca ccatctcctc
      481 cgcc
//
LOCUS       KCXD01000868             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:4807:8195
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000868
VERSION     KCXD01000868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:4807:8195"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59350.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       407..416
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          135 c          127 g          108 t
ORIGIN      
        1 acatggggct gggatctcag tgcttccttt tctgtcctcc accacgatgg ggtcaactgc
       61 catcctcacc ctcctactgg ctgttctcca aggagtctgt gccgaggtgc agctggtgca
      121 gtctggatca gaggtgaaaa ggcccgggga gtctctgaag atctcctgta agacttctgg
      181 atacagcttt accagttact ggatcacctg ggtgcgccag atgcccggga aaggcctgga
      241 gtggatgggg gcgattgatc ctagtgattc tgctaccaaa tacagcccgt ccttccaagg
      301 ccaggtcacc atttcagccg acaagtccat caccaccgcc tacctagaat ggagcagcct
      361 gaaggcctcg gacaccgcca cgtatttttg tgcgaaaggt cccggagtga ttattaacta
      421 ctttgactac tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000869             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12665:9960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000869
VERSION     KCXD01000869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12665:9960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..499
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59351.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       426..435
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..499
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          150 c          138 g          103 t
ORIGIN      
        1 acatggggat cacatagcaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtaca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgta aggcttctgg atacaccttc aacatctatg ccatcaattg ggtgcgacag
      241 gcccctggac aggggcttga gtggatggga gggatcatcc ctcttgttga tatgacaaac
      301 tacgcacaga ggttccaggg cagagtcacg attaccgcgg acacgtccac agccacagcc
      361 ttcttggaac tgagcagcct gagatctgac gacacggcca tttattactg tgcgagagcc
      421 cgggcctacg gtagcggcta ccgctcagac tggttcttcg atgtctgggg ccctggcacc
      481 ccaatcacca tctcctcagc c
//
LOCUS       KCXD01000870             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7560:16637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000870
VERSION     KCXD01000870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7560:16637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59352.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          116 a          112 c          156 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaaa taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tgtattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01000871             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5851:5668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000871
VERSION     KCXD01000871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5851:5668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..438
     V_segment       75..368
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59353.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       382..387
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..438
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           91 a          104 c          136 g          109 t
ORIGIN      
        1 acatgggaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
       61 aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg cggcttggca aagcctgggg
      121 ggtccctgag actctcctgc gcagcctctg gattcagctt cagttactac tacatgagtt
      181 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattgcc gctgatgggg
      241 atagcacata ctatgcagac tccatgaagg ccagattcac tatctccaga gagaacgcca
      301 agaacacact gcatcttcaa atggacagcc tgagagcaga ggacacggct gtctattact
      361 gtgtgagaga tcgacgtgtt cagtcgttat cctggttcga tgtctggggc ccgggagtcc
      421 tgatcaccgt ctcctcagcc
//
LOCUS       KCXD01000872             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20331:13055
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000872
VERSION     KCXD01000872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20331:13055"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..484
     V_segment       103..396
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59354.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       401..405
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           97 a          145 c          135 g          109 t
ORIGIN      
        1 acatggggat gttctctgag agtcacagac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcacttccta ctggagctgg atccgccagg ccccagggaa gggactggag
      241 tggattggat atatctatgc tgatagtggg accaccagct acaacccgtc cctcaagagt
      301 cgagtcacca tttcaataga cacgtccaag aatctgtact ccctgaaact gagctctgtg
      361 accgccgcgg acacggcctt ttattactgt gcgagacgtc ctactcgcac gcgggttcta
      421 tatgaggcga caggggaaga ctttgactcc tggggccagg gactcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000873             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10059:4129
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000873
VERSION     KCXD01000873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10059:4129"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59355.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          161 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttcag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgggtctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 gtgatgaaag taagagatac tacggagact ctgtgaagga ccgattcagc atttccagag
      361 acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgacagat gcgtttggta gcgggattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000874             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:26068:15025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000874
VERSION     KCXD01000874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:26068:15025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59356.1"
                     /translation="CARGPGCTNSDCNGEAFDFW"
     D_segment       432..438
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          115 a          138 c          145 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctatgaca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttggaac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc cagaggcccc
      421 gggtgtacta atagtgattg caacggggag gcttttgatt tctggggcca agggctcagg
      481 gtcaccgtct cttcagcc
//
LOCUS       KCXD01000875             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10087:6530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000875
VERSION     KCXD01000875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10087:6530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59357.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          135 c          136 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctctcagc ggtggttatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggc tatatctatg gtggtactgg gagcaccacc tacaacccgt ccctcaggaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttg tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagacag tgctgttact atgatgactt
      421 tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000876             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23498:14153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000876
VERSION     KCXD01000876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23498:14153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59358.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac tgagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000877             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21003:16669
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000877
VERSION     KCXD01000877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21003:16669"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59359.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       441..446
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          115 c          158 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtactttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaagaaata ctacgcagac tctgtgaagg cccgattcac cgtctccaga
      361 gacaaatcca agaacatgtt atatcttcaa atggacaacc tgaaattgga agacacggcc
      421 gtctattact gcgcgagaga tgtctggggg aggggatttg actattgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000878             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14838:13359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000878
VERSION     KCXD01000878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14838:13359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59360.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           82 a          137 c          138 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccacctc ctggtggttg ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagt ggttactggt ggggctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggttt ttcggtggta gtggtgggaa cacctactac aagtcctccc tccagagtcg
      301 agtcgccatt tcaaccgaca cgtccaagaa ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000879             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6483:11274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000879
VERSION     KCXD01000879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6483:11274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..322
     V_segment       10..261
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <253..>291
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59361.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       267..272
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..322
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>324
                     /gene="IGHG"
BASE COUNT           76 a           76 c           95 g           77 t
ORIGIN      
        1 acatgggcgg gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtggc
       61 tttggcatgc actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata
      121 tcgtatgatg aaactaagaa atattacgca gactctgtga aggaccgatt caccgtctcc
      181 agagacaatt ccaagaacat gctatatttt caaatgaaca acctgaaatt ggaagacacg
      241 gccgtatatt actgtgcgag agatgtctat ggcaggggac ttgacttctg gggcctggga
      301 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000880             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24330:6611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000880
VERSION     KCXD01000880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24330:6611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59362.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       406..421
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          135 c          131 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tggctccatc accaatagtt actggaactg gatccgccag cccccaggaa aggggctgga
      241 gtggattggg tctatctatg gtggtactgg gagcaccggc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaagc tgacctctgt
      361 gaccgccgcg gacaccgccg tttattattg tgcgagatat gaggatgaat acagtgacta
      421 ctactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000881             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6927:5829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000881
VERSION     KCXD01000881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6927:5829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59363.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          122 c          155 g          119 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcaa gtattaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000882             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23366:7567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000882
VERSION     KCXD01000882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23366:7567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..514
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59364.1"
                     /translation="CTRIWCPRDLTSGCNWFDVW"
     D_segment       456..464
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..514
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          105 a          130 c          156 g          125 t
ORIGIN      
        1 acatgggggc tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggagcacctc gtggagtctg ggggaggcct ggtccagcct
      181 ggggggtccc tgagactctc ctgtgcaggc tctggattca tctttggtga ttatggcatg
      241 cactgggtcc gccaggctcc gggaagggga ctggaatggg tctcgtccat tagtaacact
      301 ggtaaaacta tatactacac tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gcccagaact cggtgtctct gcagatgaac agcctgagag ccgaggacac ggccgtgtat
      421 tactgtacta gaatttggtg tccccgcgat ttaaccagcg gctgtaattg gttcgatgtc
      481 tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000883             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8244:19529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000883
VERSION     KCXD01000883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8244:19529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59365.1"
                     /translation="CARADRGSSIDFW"
     D_segment       444..450
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          117 c          147 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaagac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 aattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctaagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catgcactgg gtccgccagg ctccagggca ggggctggag tgggtggcgg ttatatctta
      301 tgatgatgat aagaaatact acacagactc tttgaaggac cgattcacca tatccagaga
      361 caattccaag aacactcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgagagcgg atcgcggcag ttcaattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000884             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10419:12753
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000884
VERSION     KCXD01000884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10419:12753"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59366.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       447..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          106 a          123 c          153 g          127 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcccg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtactagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgac aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggccttgtgg tttttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000885             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:7597:12147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000885
VERSION     KCXD01000885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:7597:12147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59367.1"
                     /translation="CARGMDNYHYSNTDFDYW"
     D_segment       452..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          119 c          147 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctggtg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta ccccgactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gacttgagga cactgctgtg
      421 tatttttgtg caagggggat ggataactac cactatagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000886             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5742:8372
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000886
VERSION     KCXD01000886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5742:8372"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59368.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          112 a          140 c          131 g           96 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gttggtacag tctggggttg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaga aggacttgag tggatgggag gtgttcatcc tgaatttggt aaagtagact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac ttctggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000887             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17329:4993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000887
VERSION     KCXD01000887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17329:4993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59369.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       273..285
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           80 a           81 c           93 g           78 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct
       61 tcagaaacta tggcatgcac tgggtccgcc aggccccagg gaaggggctg gattgggtgg
      121 cagttatgtc gtttgatgaa aatgtgaaat tctacgcaga ctctgtgaag gaccgattca
      181 gcatctccag agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg
      241 aggacacggc cctgtattac tgtgcgagag gggaatacag taactctatt gacttctggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000888             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11050:12448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000888
VERSION     KCXD01000888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11050:12448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59370.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          114 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtt tagcctctgg attcaccttc agtcgtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgagtcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000889             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:27021:16062
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000889
VERSION     KCXD01000889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:27021:16062"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59371.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       229..234
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       245..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           72 a           67 c           85 g           65 t
ORIGIN      
        1 acatggggga ttcaccttca gtacttttgg catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggcag ttacatcgtc tgatgaaagt aagaaatact acgcagactc
      121 tgtgaaggcc cgattcaccg tctccagaga caaatccaag aacatgttat atcttcaaat
      181 ggacaacctg aaattggaag acacggccgt ctattactgc gcgagagatg tctgggggag
      241 gggatttgac tattggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000890             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:25064:10689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000890
VERSION     KCXD01000890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:25064:10689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59372.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       442..446
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          137 c          143 g          102 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatac tgtatctgat ggagtgatat
      301 acgcagagaa cttccagggc agagtcgcca tgaccgagga cacgtctaca gacacagcct
      361 acatggaatt gagcagcctg agatctgagg acacggccgt ttattactgt gcgagaggtt
      421 tatcaccaga cgtcttcggt ttcctcgggc ttggctactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000891             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20123:14035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000891
VERSION     KCXD01000891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20123:14035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59373.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       417..425
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..474
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          109 a          141 c          135 g           91 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc aactacaggc gcccactctg
      121 aggtccttct ggtgcagtct ggggctgagg tgatgcagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggaaac accttcaccg aattgtccat gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg gtgggaagtg ttgatcctgc atatggtgaa atgacgttcc
      301 agggcagagt caccatgacc gaggacacgt ctacagacac agcctacatg gaactgagca
      361 gcctgacatc tgaggacacg gccgtgtatt actgcgcgat tggccctagt ggcagatgga
      421 acgactggtc cttcgacatc tggggacctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01000892             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:3744:7129
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000892
VERSION     KCXD01000892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:3744:7129"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59374.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          103 a          143 c          128 g          105 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tcacagccga caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000893             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13552:15004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000893
VERSION     KCXD01000893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13552:15004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..482
     V_segment       122..415
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59375.1"
                     /translation="CARADIEAATSFDFW"
     D_segment       419..425
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          122 a          132 c          130 g          100 t
ORIGIN      
        1 acatggggga ctcaacaact gcatccaacc tcaagagaag cccctgagag cacagtttct
       61 caccatggac ttgacctgga agatcctcct cttggtgaca gcagccacag gtgcccactc
      121 ccaggtgcag ctggtgcagt ctggggctga gattaagcag cctggggcct cagtgaaact
      181 ctcctgcaag gcttctggat atatctacat ggactactac atgcactggg tgagacaggc
      241 ccctggacaa ggccttgagt ggataggact gatctcccct tataatggtt acaaagggta
      301 cgcacagaac ttccaggaca gagtcaccat aattgcggac acgtccacga gcacaggcta
      361 catggagctg agaagcctga gatatgagga cacaggcatt tactactgtg cgagagcaga
      421 tattgaagcg gctacctcct ttgacttctg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01000894             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14938:6793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000894
VERSION     KCXD01000894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14938:6793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59376.1"
                     /translation="CARWEAADFDYW"
     D_segment       404..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          130 c          139 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggccat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 gtccatcagc ggtggttatg gctggagttg gatccgccag gccccaggga agggactgga
      241 gtggattggg actatgtatg gtcatagtgg cagcacccac tacaatccct ccctcaagag
      301 tcgagtcacc atttcaaaag acatgtccaa gaaccagttt tccctgacgt tgagctctct
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gaggcagcgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000895             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18772:8397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000895
VERSION     KCXD01000895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18772:8397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..496
     V_segment       118..411
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59377.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       415..434
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          106 a          140 c          146 g          106 t
ORIGIN      
        1 acatggggga acaaccacgt ccctcctcta aagaagcccc tgggaacaca gctcatcacc
       61 atggacttga cctggaggct cctctttgtg gtggcagcag ctacaggtgc ccagtctcag
      121 gtccagctgg tgcagtccgg ggctgagatg gagaagcctg gggcctcagt gaagctctcc
      181 tgtaaggctt ctggatacac cttgagcatc tatgtcatca gttgggtgcg acaggcccct
      241 ggacaagggc ttgagtggat gggaggcatc ttccctcttg ttggtacaac aaactacgca
      301 cagaagttcc agggcagagt cacgattacc gcggacacgt ccacaagcac agcctacatg
      361 gacctgagca gcctgggatc tggggacacg gccgtctatt attgtgcgag aggctactgt
      421 actggtagtg gttgtaacct tacattcaac cggctcgatg tctggggccc gggagtcccg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000896             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21838:18766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000896
VERSION     KCXD01000896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21838:18766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59378.1"
                     /translation="CARVRGVNIHYFDYW"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           81 a          148 c          137 g           97 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc gcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactcct ggagctggat ccgccagccc ccaggcaagg gtctggagtg
      241 gattggacat gtcagtggta gtagtgggag caccgactac cacccctccc tcaagagtcg
      301 agtcaccgtt tcaacagaca cgtccaagcg ccagttctcc ctgaggctga tctctgtgac
      361 cgccgcggac acggccgtct atcactgtgc gagagtccgg ggcgttaaca tccactactt
      421 tgactactgg ggccagggag ccctggtcac cgtcgcctca gcc
//
LOCUS       KCXD01000897             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10236:5578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000897
VERSION     KCXD01000897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10236:5578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59379.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       416..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          139 c          129 g          105 t
ORIGIN      
        1 acatgggcaa cgcagagtac atgggtggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gcctggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatctctgg tgcttatggg agtaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaactga cacgtccaag aaccagtttt ccctgaggct ggcttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggacgaatc cataaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000898             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:3731:13165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000898
VERSION     KCXD01000898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:3731:13165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59380.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       414..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          108 a          139 c          138 g           98 t
ORIGIN      
        1 acatggggag agcatccaac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccttctggt gcagtctggg gctgaggtga tgcagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgaat tgtccatgca ctgggtgcga
      241 caggcccctg gaaaaggact tgagtgggtg ggaagtgttg atcctgcata tggtgaaatg
      301 gtgttccagg gcagagtcac catgaccgag gatacgtcta tagacacagc ctacatggag
      361 ttgagcagcc tgagatctga ggacacggcc gtttattact gcgcgattgg ccctagcggc
      421 aactggaacg gctggtcctt cgatatctgg ggacctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01000899             399 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:25767:11320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000899
VERSION     KCXD01000899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 399)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 399)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:25767:11320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    31..397
                     /note="immunoglobulin heavy chain variable region"
     V_region        31..397
     V_segment       31..324
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <316..>366
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59381.1"
                     /translation="CARVGEDTGGAEDFDFW"
     D_segment       336..342
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       353..397
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        398..>399
                     /gene="IGHG"
BASE COUNT           89 a           91 c          123 g           96 t
ORIGIN      
        1 acatgggcta ttttaagagg tgtccagtgt gaggtacaac tggtggagtc tggaggaggc
       61 ttggttcagc ctggggggtc cctgagactc tcctgtgcag cctccggatt caccttcagt
      121 acctttggca tgcactgggt ccgccaggct ccagggaagg gactggagtg ggtggcactg
      181 atatcgtatg atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccctc
      241 tccagagaca attccgagaa catcctatat cttcaaatga acaacctgaa attggaggac
      301 acggccgtgt atttttgtgc gagagttgga gaggatactg gtggtgcgga ggactttgac
      361 ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000900             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8494:18450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000900
VERSION     KCXD01000900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8494:18450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59382.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       257..262
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           78 a           78 c           88 g           75 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      121 tgatggaagt aagaaatact acgcaaactc tgtgaaggac cgattcacca tctccagaga
      181 caattccaag aacatactct atcttcaaat gaacaacctg aaattggagg acacggccgt
      241 ctattactgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      301 ggtcatcgtc tcctcagcc
//
LOCUS       KCXD01000901             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:24223:4445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000901
VERSION     KCXD01000901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:24223:4445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59383.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       403..412
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          109 a          105 c          145 g          115 t
ORIGIN      
        1 acatggggga gatcgagtgg gagtggacat gagtaagaga aacagtggat atgtgtggca
       61 gtttctgacc ttggtgtctc tctgtttgca ggtgtccagt gtgaggtgca cctggtggag
      121 tctggaggag gcttggttca gccggggggg tccctgagac tctcctgtgc agcctctgga
      181 ttcaccttca gtagctatgg catgcactgg gtccgccagt ctccagggga ggggctggaa
      241 tgggtggcgc ttatatcgta tgatggaact aagaaatact acgcagactc tatgaaggac
      301 cgattcacca tctccagaga caattccaag aacatgctat atcttcaaat gaacaacctg
      361 aaattggagg acacggccgt ctattactgt gcgagagtaa gcggtataac tgaaagttcc
      421 gttgaatact tcgagttctg gggccagggc gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000902             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12567:20698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000902
VERSION     KCXD01000902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12567:20698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59384.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          123 c          149 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga gtctggagga ggcttcattc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccctc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggagg taggaaatac tacgcagact ctttgaaagc ccgattcacc atatccagag
      361 acaactccaa gaacatagta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01000903             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22273:6214
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000903
VERSION     KCXD01000903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22273:6214"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59385.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          114 c          150 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatgcaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000904             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16541:19823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000904
VERSION     KCXD01000904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16541:19823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59386.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          113 c          149 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaag tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgca agctctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctg caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatctt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000905             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:8743:3947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000905
VERSION     KCXD01000905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:8743:3947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59387.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       275..281
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           77 a           86 c           92 g           77 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct
       61 tcagtacctc tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtggctga
      121 cagttatatc gtatgatgaa actaagaaat actacgcaga ctctgtgaag gaccgattca
      181 ccatctccag agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg
      241 aggacgcggc cgtgtattac tgtgcgagag attcttacgg tcgaggcttt gactcctggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000906             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:9838:2698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000906
VERSION     KCXD01000906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:9838:2698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..476
     V_segment       110..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59388.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       416..421
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          131 c          138 g          101 t
ORIGIN      
        1 acatggggac acatccctcc cctacagaag ccccagagca cagcacctca ccatggactg
       61 gacctggagg atcctcctct tggtggcagc aggtacaggc gcccactctg aggtccagct
      121 ggtgcagtcg ggggctgagg tgaagaagcc tggggcctca gtgaaggtct cctgtaaggt
      181 ttccggatac accttcaccg aattatccat gcactgggtg cgacaggccc ctggaaaagg
      241 gcttgagtgg atgggaagtg ttgatcctgt ttttggtgaa ataatgaatt cagagaagtt
      301 ccagggcaga gtcgccttga ccgaggacac gtctacagac acagcctaca tggagttgag
      361 cagcctgaga tctgaggaca cggccgtgta ttactgtgcg acatcatcca gcggtacctg
      421 gctatattgg tacttcgatg tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01000907             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20706:3515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000907
VERSION     KCXD01000907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20706:3515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59389.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       434..440
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          115 a          114 c          158 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcacttata tcgtttgatg
      301 gaactaagca atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt gggggacacg gccgtgcatt
      421 actgtgcgag agttagtggg catacagagg gaacagttga atactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000908             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:12125:12884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000908
VERSION     KCXD01000908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:12125:12884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59390.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           91 a          139 c          131 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc aacactcaac tctccctgaa ggtgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000909             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19171:18589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000909
VERSION     KCXD01000909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19171:18589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59391.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          118 c          152 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtttttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000910             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:20161:9147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000910
VERSION     KCXD01000910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:20161:9147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59392.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          134 c          128 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcgg tgtctctggt
      181 gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000911             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15254:3861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000911
VERSION     KCXD01000911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15254:3861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..437
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59393.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       373..380
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>441
                     /gene="IGHG"
BASE COUNT           91 a          129 c          120 g          101 t
ORIGIN      
        1 acatgggtgt gcaagaacat gaagcacctg tggttcttcc ttctcctggt ggcagttccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacctg cgctgtctct ggtgactcca tcagcagtag ctactggaac
      181 tggatccgcc agcccccagg gaagggactg gagtggattg gatatatctc tggtgcttat
      241 gggagcacca gctacaaccc ctccctcaag agtcgagtca ccatttcaac agacacgtcc
      301 aagaaccact tttccctgag actgagttct gtgaccgccg cggacaccgc cgtgtattac
      361 tgtgtgagat atgaggatga atccattaac taccactttg actactgggg ccagggagtc
      421 ctggtcaccg tctcctcggc c
//
LOCUS       KCXD01000912             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13723:7509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000912
VERSION     KCXD01000912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13723:7509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..476
     V_segment       134..393
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59394.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       396..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          101 a          115 c          146 g          116 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tctgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggatt
      181 cagctttggc gatcatggca tgcactgggt ccgccaggct ccgggaaagg gactggagtg
      241 ggtctcatct atcagtaata ctggtaaagc cgtacactac gctgactccg tgaagggccg
      301 attcaccatc tccagagaca acgccaagaa ctcgctgtct ctgcaaatga gcagcctgag
      361 agccgaggac acggccgtgt attactgttc tagcgattac tatagtggta gttattacta
      421 ttggggctac ggcttggatt cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01000913             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7000:17155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000913
VERSION     KCXD01000913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7000:17155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..492
     V_segment       116..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59395.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       411..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          103 a          138 c          146 g          107 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcgggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt tactgtactg
      421 gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000914             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:25893:10643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000914
VERSION     KCXD01000914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:25893:10643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..318
     V_segment       8..248
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59396.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       258..264
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..318
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           69 a           83 c           96 g           72 t
ORIGIN      
        1 acatggggag actctcctgc gcagcctctg gattcagttt cagtcactac ttcatgagct
       61 gggtccgcca ggctccaggg aaggggctgg agtggatctc agggattaac agtggtgggg
      121 atactacata ccacgcagac tccgtgaagg gcagattcac catgtccaga gagaacgcca
      181 agaacacact gtctcttcaa atggacggcc tgagagctga ggactcggct gtctattact
      241 gtgcgagaga tcgacgtgta cagtcgttat cttggttcga tgtctggggc ccgggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000915             340 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24417:13613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000915
VERSION     KCXD01000915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24417:13613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..338
     V_segment       8..274
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>307
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59397.1"
                     /translation="CTGGAYANLDYW"
     D_segment       287..291
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..338
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>340
                     /gene="IGHG"
BASE COUNT           76 a           92 c          104 g           68 t
ORIGIN      
        1 acatgggggg ggcggcttgg caaaacctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtaact actggatgaa ctgggtccgc cagactccag gaaaggggct
      121 ggagtgggtc tcagctatta attatgatgg gggtagcgca tactacgcag actccgtgaa
      181 gggccgattc accatttcca gagacaactc aaagagtacg ctctccctgc aaatgagcag
      241 cctgagagcg gaggacacgg ccgtatatta ctgtacgggc ggggcatacg ctaacctcga
      301 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000916             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12412:6588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000916
VERSION     KCXD01000916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12412:6588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..383
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <373..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59398.1"
                     /translation="CARVVAAGVDSW"
     D_segment       388..396
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           89 a          141 c          110 g          101 t
ORIGIN      
        1 acatgggggt gaatcctgtg ccccaccatg gacacgcttt gctacacact cctgctactg
       61 accgtcccgt cctgggtctt gtcccaggtc accttgaagg agtctggtcc tgcgctcgtg
      121 agacccacac agaccctcac gctgacctgc accttctctg ggttctcaat cgacactctc
      181 gcaacaggtg tgggctggat ccgtcagccc cccgggaagg ccctccaatt gcttgcaagc
      241 atttattgga atgatagtag attctacatc acatcgctga agagccggct caccatctcc
      301 aaggacacct ccaataacca ggtggttctg acaatgaccg acatggatcc tttggacaca
      361 gccacatatt actgtgcacg cgttgtggca gctggtgtgg actcctgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000917             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13865:19918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000917
VERSION     KCXD01000917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13865:19918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59399.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          140 c          132 g           97 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gttaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaatt tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 ttggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01000918             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5325:5977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000918
VERSION     KCXD01000918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5325:5977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..431
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59400.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          116 a          122 c          147 g          129 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 ttctatatta aaaggtgtcc agtgtgtgga gcatctggtg gagtctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct gaattcacct tcagtggcta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtcta gaatgggtat caggtattaa
      301 cattggcggt gacccatact acccagactc tgtgaagggt cgattcacca tctccagaga
      361 caacgccaag aactccttgt atcttcaaat gaacaacctg agacctgagg acactgctgt
      421 gtattattgt gtgaggggga tggataacta ccacttcagt aatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01000919             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17983:12853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000919
VERSION     KCXD01000919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17983:12853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..479
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59401.1"
                     /translation="CASQPYYYDSGYQYNLLDVW"
     D_segment       404..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..479
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           98 a          135 c          134 g          114 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg ctgtctctgg
      181 tggctctatc agcagaagtt actggagttg gatccgccag gccccaggga agggactgga
      241 gtggattggg tatatttctg gtagtggcag tagcaccaac tacaacccct ccctcaagaa
      301 tcgagtcacc ctgtcagtag acacgcccaa gaaccacctc tccctgaacc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagtcaa ccttattact atgatagtgg
      421 ttatcagtac aatttattgg acgtctgggg ccggggagtt ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01000920             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:7853:11168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000920
VERSION     KCXD01000920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:7853:11168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59402.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          116 c          149 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaagttc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ttcctcagcc
//
LOCUS       KCXD01000921             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:6033:7710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000921
VERSION     KCXD01000921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:6033:7710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59403.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       438..445
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          119 c          154 g          122 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gtgaatcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttat ttctacatga
      241 gctgggtccg tcaggctcca ggaaaggggc tggagtggat ctcaagtatt gacaatggtg
      301 ggactaccac aaattttgca gactccgtga ggggcaggtt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 attgtgcgag agcgcgcggg gtgatcatta catactttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000922             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18491:11426
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000922
VERSION     KCXD01000922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18491:11426"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..482
     V_segment       121..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59404.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       412..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>486
                     /gene="IGHG"
BASE COUNT          116 a          143 c          126 g          101 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccacc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggcta caccttcgcc gaattgccca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt tttgcttcta tatatggtga aataatacat
      301 acagagagat tccagggcag agtcaccatt acagcggaca cgtctataga cacagcctac
      361 atggaactca gcagcctgac atctgaggac acggccgtgt attactgtgc ggcagctgat
      421 agtggttacc cattttacta cttcgatatc tggggccctg gcaccccaat caccatctcc
      481 tccgcc
//
LOCUS       KCXD01000923             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:25574:20322
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000923
VERSION     KCXD01000923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:25574:20322"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59405.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          140 c          126 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc cccgggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 ctccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000924             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23541:4926
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000924
VERSION     KCXD01000924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23541:4926"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..473
     V_segment       107..398
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59406.1"
                     /translation="CAKKYRGSYFYSHFDYW"
     D_segment       408..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           99 a          133 c          133 g          110 t
ORIGIN      
        1 acatgggggc tgtctgagag tcagggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc
      181 tggtggctct atcagcgatt actcctggag ctggatccgc cagaccccag ggaagggact
      241 ggagtggatt ggagatattg atgataatat tgggggcatc aagtacaaat cctccctcag
      301 gagtcgagtc accatttcaa aagacacgtc caagaatcag ttgtccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtctatta ctgtgcgaaa aagtatcgtg gtagttattt
      421 ctactcccac tttgactact ggggccaggg aatcctggtc accgtctcct cagcc
//
LOCUS       KCXD01000925             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13576:19418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000925
VERSION     KCXD01000925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13576:19418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59407.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..433
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          111 a          138 c          145 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacttcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atactcgttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtgtatgg tgaagaaata
      301 cacgcagaga atttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagacctgag gacacggccg tgtatttctg tgcggcgggc
      421 cttgggggat atttagtgct tactgaatac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01000926             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19539:3940
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000926
VERSION     KCXD01000926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19539:3940"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59408.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       417..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          119 a          141 c          134 g           94 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagga gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac acggcctaca
      361 tggagctgag cagcctaaga tcagaggaca cggccctgta ttactgtgca gtcggatata
      421 gcggcagatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01000927             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:19960:4562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000927
VERSION     KCXD01000927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:19960:4562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59409.1"
                     /translation="CVRDVRVTGFDFW"
     D_segment       446..451
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          110 c          154 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaatacggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtcagggtaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01000928             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9137:16441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000928
VERSION     KCXD01000928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9137:16441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59410.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          140 c          154 g          104 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccct
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgagg aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggttggg aggtgttgat cctgcaaatg gtgaggtaat
      301 acacgcagat agttttcagg gcagagtcac catgaccgag gacacgtcta cactcacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 gcggttcggt agcagcgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01000929             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11084:8375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000929
VERSION     KCXD01000929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11084:8375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59411.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       403..409
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..463
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          104 a          107 c          141 g          113 t
ORIGIN      
        1 acatgggctg ttcggcgatc agcacaaaac acagaacata ccatggagtt tgtgctgagc
       61 tgggttttcc ttgttgctct tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct
      121 gggggcggct tggcaaagcc tggggggtcc ctgagactct cctgcgcagc ctctggattc
      181 agcttcaatt attactatat gagttgggtc cgccaggctc cagggaaggg gctggagtgg
      241 atctcaggta ttaatagtgg tggggaaagc acatactctg cagactccgt gaagggcaga
      301 ttcaccatct ccagagagaa cgccaagaaa acagtatatc ttcaaatgga cagcctgaga
      361 actgaggaca cggctgtcta ttactgtgtg agagatcgac gtgtacagtc cttatcctgg
      421 ttcgatgtct ggggcccggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000930             335 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12491:13579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000930
VERSION     KCXD01000930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 335)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 335)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12491:13579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..333
     V_segment       8..272
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <264..>302
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59412.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       273..278
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       288..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>335
                     /gene="IGHG"
BASE COUNT           86 a           90 c           91 g           68 t
ORIGIN      
        1 acatgggggt gaagaagcct ggggcctccg tgaaaatctc ctgccaggct tctgaataca
       61 ccttaaccga ccactacctg cactgggtgc gacaggctcc tggaaaagga cttgagtgga
      121 tgggaggtat tcatcctgaa tatggtaaag tagactacac acagaagttc cgagacagaa
      181 tcaccatcac cgcggacatg tcgacagaga cagcctacat ggagctgagc agcctgagat
      241 ctgaggacac ggccacttat tactgtgtga cagtgggtcc ctaccattac tttgactact
      301 ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01000931             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12154:18462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000931
VERSION     KCXD01000931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12154:18462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59413.1"
                     /translation="CARDVYGCGLDYW"
     D_segment       442..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          113 c          155 g          120 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtccacct ggtggaatct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc gccttcagta ggtttggcat
      241 gcactgggtc cgccagactc caggaaaggg gctggagtgg gtggcagtta tgtcgtctga
      301 tggaagtagg atatactacg cagactcttt gaaagaccga ttcaccatat ccagagacaa
      361 ttccaagaac atgctatatc ttcaactgaa caacctgaaa ttggaggacg cggccgtgta
      421 ttactgtgcg agagatgtct atggctgtgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcg tcagcc
//
LOCUS       KCXD01000932             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13221:12565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000932
VERSION     KCXD01000932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13221:12565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59414.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 atgatgaaac taggaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacccggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcagcgt ctcctcagcc
//
LOCUS       KCXD01000933             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7235:18272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000933
VERSION     KCXD01000933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7235:18272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..517
     V_segment       142..431
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59415.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       469..475
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..517
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          111 a          124 c          162 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtatttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcac ctggtgcagt ctgggggcgg cttgacaaag
      181 ccgggggggt ccctgagact ctcctgtgca gcctccggat tcaccttcag tgactactat
      241 atggactggg tccgccaggc tccagggaag gggctggagt gggtctcacg aatcggtcat
      301 gatggtggta gcacatggta cgcagactcc gtgaagggca gatttaccat ttccagagag
      361 aatgccaaga acacactgtt tcttcaaatg gacagcctga gaagtgagga cacagccgta
      421 tattactgtg ccagagagcg gtttggggga attggggtaa ttatcttcaa ctggatcgat
      481 gtctggggcc cgggagtcct ggtcaccgtc ccctcagcc
//
LOCUS       KCXD01000934             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7168:20122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000934
VERSION     KCXD01000934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7168:20122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..481
     V_segment       112..403
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59416.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       412..422
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          100 a          141 c          138 g          104 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag
      121 ctgcaggagt cgggcccagg actgctgaag cctttggaga ccctgtccct cacctgcgct
      181 gtctctggtg gctccatcag cagtaactac tggagctgga tccgccagtc cccagggaag
      241 ggactggagt ggattggacg tatctctggt agtggtggga acaccgtcta caacccctcc
      301 ctcaagagtc gagtcaccat ttcaacagac acgtccaaga accagatctc cctgaaagtg
      361 acctctgtga ccgccgcgga cacggccgtg tattattgtg cgacagccgg atatagcagc
      421 agggaaagct tctacggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01000935             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14342:5464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000935
VERSION     KCXD01000935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14342:5464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59417.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       300..305
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       318..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           84 a           84 c          109 g           85 t
ORIGIN      
        1 acatgggggt gcaactggtg gagtctggag ggggcttggt tcagcctggg gggtccctga
       61 gactctcctg tgcagcctct ggattcacct tcagtaactt tggcatacac tgggtccgcc
      121 aggctccagg gaaggggctg gagtgggtgg cagttatttc atctgatgga agtaagaaat
      181 actacgcaaa ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatag
      241 tatatcttca aatgaacagc ctgaaattgg aggacacggc cgtctattac tgtgcgagag
      301 atgatatggg gaccggtttt gactactggg gccagggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01000936             352 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18918:14370
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000936
VERSION     KCXD01000936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 352)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 352)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18918:14370"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..350
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..350
     V_segment       7..287
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <281..>319
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59418.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       295..300
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..350
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        351..>352
                     /gene="IGHG"
BASE COUNT           73 a           91 c          113 g           75 t
ORIGIN      
        1 acatggggtg gagtctgggg gcggcttggc aaagcctggg gggtccctaa gactctcctg
       61 tgcagcctcc ggattcacct tcagtgacca ctgcatgcac tgggtccgcc aggcttcagg
      121 gaaggggctg gagtgggtct caggtattac ttataggggt gttaccacat ggtacgcaga
      181 ctccgtgagg ggcagattca ccatctccag agagaacgcc aagaacacat tgtattttca
      241 aatggacagc ctgagagctg aggacacggc tgtctattac tgtgtgacag gacggcggca
      301 cgtggacctt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000937             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18927:10198
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000937
VERSION     KCXD01000937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18927:10198"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    19..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        19..373
     V_segment       19..312
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <304..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59419.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       321..327
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       334..373
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           87 a           84 c          116 g           88 t
ORIGIN      
        1 acatggggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
       61 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttatggcatg
      121 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgacagttat atcgtatgat
      181 gtaagtaaga aatactacgc agacgctgtg aaggaccgat tcaccatctc cagagacaat
      241 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      301 tactgtggga gagatgataa tggggtgctt atcgactact ggggccaggg agtcctggtc
      361 accgtctcct cagcc
//
LOCUS       KCXD01000938             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9793:13227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000938
VERSION     KCXD01000938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9793:13227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59420.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          141 c          150 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgaaatg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gtgaaataat
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgagatctga ggacacggcc gtatattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccagcct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01000939             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24251:14625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000939
VERSION     KCXD01000939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24251:14625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..363
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59421.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       291..308
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       313..363
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           76 a          102 c          104 g           83 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg
       61 tctctggtgg ctccttcagc ggttactatt ggagctggat ccgccagtcc ccagggaagg
      121 ggctggagtg gattgggtat atcagtgcta gtagtgggag taccgactac aacccctccc
      181 tcaagagtcg agtcaccatt tcaacagaca cgtccaatta ccatttctcc ctgaagctga
      241 cctctgtgac cgccgcggac acggccgtat attactgtgc gagagagaag tactatagtg
      301 gtagttataa acacaactgg ttcgatgtct ggggcccggg agtccaggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01000940             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19561:14812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000940
VERSION     KCXD01000940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19561:14812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    129..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        129..495
     V_segment       129..420
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <414..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59422.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       434..440
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..495
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          124 a          142 c          135 g           96 t
ORIGIN      
        1 acatggggag agagcatcac acaacaacca catccctccc ctacagaagc cccagagcac
       61 agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg
      121 cccactctga ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag
      181 tgaaggtctc ctgcaaggtt tccggataca tcttaaccga attatccatc cactgggtgc
      241 gacaggcccc tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa
      301 tgatagacgc agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca
      361 cagcctacat ggagctgagt agtctgagat ctgaggacac ggccgtgtat tactgtgcga
      421 catcatccag cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa
      481 tcaccatctc ctcagcc
//
LOCUS       KCXD01000941             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22736:7599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000941
VERSION     KCXD01000941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22736:7599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..279
     V_segment       7..194
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <186..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59423.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       203..210
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..279
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           62 a           67 c           94 g           58 t
ORIGIN      
        1 acatgggggt gcgacaggcc cctggaaaag ggcttgagtg gatgggaggt gttgaccctg
       61 caaatggtga aataatacac gcagatagtt tccagggcag agtcaccatg accgaggaca
      121 cgtctacaga cacagcctac atggagctga gcggcctgag atctgaggac acggccgtgt
      181 attactgtgc gagagggggg ttcggtagca gtgtctggtc caatctcgtc tatggtttgg
      241 attcctgggg ccaaggggtc gccgtcaccg tctcctcagc c
//
LOCUS       KCXD01000942             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13308:17899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000942
VERSION     KCXD01000942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13308:17899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59424.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       425..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          113 c          145 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccggtgt gaggtgcaac tggtggagtc tggagggggc ttggttcagc cgggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca tacactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcatctg atggaagtaa
      301 caaatactac gcaaactctg tgaaggaccg atttaccatc tccagagaca attccaagaa
      361 catagtatat cttcaaatga acaacctgaa atcggaggac acggccgtct attactgtgc
      421 gagagatgat atggggaccg gttttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000943             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10486:7088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000943
VERSION     KCXD01000943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10486:7088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59425.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          110 a          122 c          157 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtgttaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000944             436 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:23744:14052
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000944
VERSION     KCXD01000944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:23744:14052"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..434
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..434
     V_segment       83..370
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>403
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59426.1"
                     /translation="CTGGAYANLDYW"
     D_segment       383..387
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..434
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        435..>436
                     /gene="IGHG"
BASE COUNT           96 a          108 c          136 g           96 t
ORIGIN      
        1 acatggggaa cacagaggac tcaccatgga gtctggactg agctgggttt tccttgttgc
       61 tattttaaga ggtgtccagt gtgaggtgca gatggtggag tctgggggcg gcttggcaaa
      121 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactactg
      181 gatgaactgg gtccgccaga ctccaggaaa ggggctggag tgggtctcag ctattaatta
      241 tgatgggggt agcgcatact acgcagactc cgtgaagggc cgattcacca tttccagaga
      301 caactcaaag agtacgctct ccctgcaaat gagcagcctg agagcggagg acacggccgt
      361 atattactgt acgggcgggg catacgctaa cctcgactac tggggccagg gagtcctggt
      421 caccgtctcc tcagcc
//
LOCUS       KCXD01000945             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10510:10080
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000945
VERSION     KCXD01000945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10510:10080"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59427.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          146 c          135 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaagtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca ggatttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aggggcttga gtggatggga agtgttgatc ctctgtatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta cttggaactg
      361 agcggcctga cttctgagga cacggccgtg tattactgtg cgactggccc taccggcacc
      421 tggaacgcct ggtacctcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01000946             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13674:12457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000946
VERSION     KCXD01000946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13674:12457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59428.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          114 c          153 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc atttggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtcgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gaaactttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggctg ttatctcgta
      301 tgatgaaaat accaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aatatgctat atcttcaaat gaacaacctg aaattggggg acacggccgt
      421 gtattattgt gtgcgagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000947             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24104:2835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000947
VERSION     KCXD01000947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24104:2835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..510
     V_segment       135..426
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59429.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          111 a          121 c          158 g          122 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtat ttctgttcgg cgatcagcac
       61 taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg cacctggtgc agtctggggg cggcttgaca aagcctgggg
      181 ggtccctgag actctcctgt gcggcctccg gattcacctt cagtgactac tatatggact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtctc acgaatcagt catgatggtg
      301 atagcacatg gtacgcagac tccgtgaagg gcagatttac catttccaga gagaatgcca
      361 agaacacact gtttcttcaa atggacagcc tgagaagtga ggacacagcc gtatattact
      421 gtgcgagaga gcgttttggg ggaattgggg tgattatctt caactggatc gatgtctggg
      481 gcccgggagt cctggtcacc gtcccctcag cc
//
LOCUS       KCXD01000948             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8428:20012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000948
VERSION     KCXD01000948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8428:20012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..451
     V_segment       94..386
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <379..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59430.1"
                     /translation="CAREGISASGVDYW"
     D_segment       390..396
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           81 a          132 c          144 g           96 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg tagctcccac atgggtcctg tcccaggtgc aacttcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga gtggattggg
      241 tttttcggtg gtcgcaatgg gaacacgtac tacaacccct ccctcaagag tcgagtcacc
      301 atttcaccag acacgtccaa agagcagttc tccctgaggc tgaggtctgt gaccgccgcg
      361 gacacggccg tgtattactg tgcgagggag gggatatcag cgtcgggggt cgactactgg
      421 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000949             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11088:10488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000949
VERSION     KCXD01000949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11088:10488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59431.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          118 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactttg
      241 gcttacactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatctcgc
      301 atgatggcaa taacatatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatggta tatcttgaaa tggacaacct gcaattggag gacacggccg
      421 tgtatttctg tgtgagggat gcctacggta ccgggttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01000950             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18681:9306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000950
VERSION     KCXD01000950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18681:9306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59432.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       423..432
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          141 c          128 g          100 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat ccctgcactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agttttaatc ctatttatgg tgaaatgtta
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagaagcct gatatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt atccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01000951             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12941:19991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000951
VERSION     KCXD01000951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12941:19991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..475
     V_segment       122..415
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59433.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       419..434
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>478
                     /gene="IGHG"
BASE COUNT          102 a          147 c          124 g          105 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcatttc tgtcctccac
       61 cacgatgggg tcaactgcca tcctcgccct cctcctggct gttctccaag gagtctgtgc
      121 cgaggtgcag ctggtgcagt ctggaacaga ggtgaaaagg cccggggagt ctctgaggat
      181 ctcctgtcag acctctggat acaactttcc cagcagctgg atcacctggg tgcgccagat
      241 gcccgggaaa ggcctggagt ggatggggac catctatcct gctgattcta atgccaaata
      301 caacccgtcc ttccaaggcc acgtcactat ctcagtcgac aagtccatca gcaccaccta
      361 cttgcagtgg agcaacctga aggcctcgga caccgccacg tattactgtg ccaaaaccta
      421 ctatagtggt agtttggaat actggggcca gggagtcctg gtcaccgtct cctcaacc
//
LOCUS       KCXD01000952             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6269:16284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000952
VERSION     KCXD01000952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6269:16284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59434.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       441..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          110 c          153 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgatccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgacagttat atcgtatgat
      301 gtaagtaaga aatactacgc agacgctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtggga gagatgataa tggggtgctt atcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000953             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19518:19621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000953
VERSION     KCXD01000953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19518:19621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59435.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          151 c          131 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaaccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtctccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacgt
      301 tccagggcag agtcatcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac acggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gcccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01000954             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16393:18475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000954
VERSION     KCXD01000954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16393:18475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..503
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59436.1"
                     /translation="CASPPRYCSGGVCYAAEYFEFW"
     D_segment       426..453
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>507
                     /gene="IGHG"
BASE COUNT          117 a          149 c          144 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattac ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga ggtgttgatc ctgtatatga tggaataaca
      301 cacgcagaga agttccaggg cagagtcacc atgaccgaag acacgtcgac agacacagcc
      361 tacatggaac tgagtggcct gagatctgag gacacggccg tgtattactg tgcgagcccc
      421 cccagatatt gtagtggtgg tgtctgctac gccgctgaat acttcgagtt ctggggccag
      481 ggcgccctgg tcaccgtctc ctccgcc
//
LOCUS       KCXD01000955             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:17777:13567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000955
VERSION     KCXD01000955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:17777:13567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59437.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       443..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          122 c          146 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgctgcta
      121 ttttaagagg tgtccagtgt gaggtccacc tggtggaatc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt tcctttggca
      241 tgcactgggt ccgccaggca ccggggaagg ggctggagtg ggtggcagtt ttatcgtctg
      301 atggaactaa caaatactac gcagactctt tgaaagaccg attcaccata tccagagaca
      361 actccaagaa catactatat cttcaactga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagagatgtg tatggctcgg ggcttgacta ctggggccag ggagtcctgc
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000956             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16507:2611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000956
VERSION     KCXD01000956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16507:2611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59438.1"
                     /translation="CARDKGYSAVRRFDVW"
     D_segment       404..410
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           85 a          143 c          135 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc agtaactcct ggaactggat ccgccagccc ccaggggagg gactggagtg
      241 gattggacgt atctctggtc ttagtgggag caccgactac aatccctccc tcacaagtcg
      301 agtcaccatt tcagcagaca cgtccaagat ccagttctcc ctgaggctaa cctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagataag ggttacagtg cagttcgacg
      421 gttcgatgtc tggggcccgg gagtcctggt ctccgtctcc tcagcc
//
LOCUS       KCXD01000957             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18301:20454
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000957
VERSION     KCXD01000957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18301:20454"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59439.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           93 a          150 c          132 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccacga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggctactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac cacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actattcttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01000958             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17310:15604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000958
VERSION     KCXD01000958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17310:15604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59440.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       448..453
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          155 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag agcacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtaaaatcg
      301 tttgatggaa ctaagatata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgtgagaga tgcctacggg agcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01000959             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11254:17579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000959
VERSION     KCXD01000959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11254:17579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59441.1"
                     /translation="CAREYCTTADCAGFFDSW"
     D_segment       408..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          106 a          127 c          142 g          110 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg atttaccttc gacaactatg gaatcaactg ggtgcggcag gcccctggac
      241 aagggcttga gtggatggga gtggtcatcc cccttcttgg tattattaat tatgcagaga
      301 acttccaggg cagagtaacg attaacgcgg acacgtccat aagcacagcc ttcatggagt
      361 tcaggagcct gagatctgac gacacggcca tttatttctg tgcgagagaa tactgtacaa
      421 ctgcggattg cgccgggttc tttgactcct ggggccaggg agtcatggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01000960             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16939:9693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000960
VERSION     KCXD01000960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16939:9693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..484
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59442.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       428..433
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           94 a          149 c          131 g          112 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccacgac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccttcagcg gctactactg gagctggatc cgccagcccc cagggaaggg actggagtgg
      241 attgggcata tcagtgggag tagtgggagc accgactaca acccctccct caaaagtcga
      301 gtcaccattt caacagacac gtccaagagc cacttctccc tgaaactgag ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagagtttt ccccctacga ctattcttgg
      421 agtgattttt actcttacta ctttgactac ttgggccagg gactcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01000961             386 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20620:2140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000961
VERSION     KCXD01000961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 386)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 386)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20620:2140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    18..384
                     /note="immunoglobulin heavy chain variable region"
     V_region        18..384
     V_segment       18..309
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <303..>353
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59443.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       323..329
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       333..384
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        385..>386
                     /gene="IGHG"
BASE COUNT           94 a          101 c          111 g           80 t
ORIGIN      
        1 acatgggcgc ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg
       61 gggcctcagt gaaggtctcc tgcaaggttt ccggatacat cttaaccgaa ttatccatac
      121 actgggtgcg acaggcccct ggaaaagggc ttgagtggat gggaagtgtt gatcctcaat
      181 atggtgaaat gatagacgca gagaaattcc agggcagagt caccatgacc gaggacacgt
      241 ctacagacac agcctacatg gagctgagca gtctgagatc tgaggacacg gccgtgtatt
      301 actgtgcgac atcatccagc ggcacctggc tatactggta cttcgatatc tggggccctg
      361 gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01000962             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14509:3094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000962
VERSION     KCXD01000962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14509:3094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..491
     V_segment       128..421
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59444.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       431..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          120 c          146 g          118 t
ORIGIN      
        1 acatgggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag cacaaaacac
       61 agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt tgaaaggtgt
      121 ccagtgtgag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg gggggtccct
      181 gagactctcc tgcgcagcct ctggattcag cttcaattat tactacatga gctgggtccg
      241 ccaggctcca gggaaggggc tggagtggat ctcaggtatt aatcatggtg gggaaagtac
      301 atactatgca gactccgtga agggcagatt caccctctcc agagagaacg ccaagaacac
      361 actatatctt caaatggaca gcctgagaac tgaggacacg gctgtctatt actgtgtgag
      421 agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag ccctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01000963             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18354:3692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000963
VERSION     KCXD01000963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18354:3692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59445.1"
                     /translation="CARDSSWYNWNQDFDYW"
     D_segment       428..441
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          107 a          142 c          139 g          104 t
ORIGIN      
        1 acatggggag ggtccagctc acatgggaaa tgttctctga gactcacgga catcctgtgc
       61 aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag atgggtcctg
      121 acccagctgc agcttcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 ctcaaatgcg ctgtctctgg tggctccatc accggtaact actggagctg gatccgccag
      241 cccccaggga agggactgga gtggattgga cgtagcactg atagtggtgg gagtactgac
      301 tacaacccct ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccagttc
      361 tccctgaagc tgagctctgt gaccgccgcg gacacggccg tgtattactg tgcgagagat
      421 agtagttggt ataactggaa ccaagacttt gactactggg gccagggact cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01000964             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24658:7406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000964
VERSION     KCXD01000964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24658:7406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59446.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          116 c          152 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtttctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc cggagtgggt gtctgtaatt tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacat actatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000965             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7126:9656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000965
VERSION     KCXD01000965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7126:9656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59447.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          119 a          139 c          134 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga gttatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgattt ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01000966             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15356:16537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000966
VERSION     KCXD01000966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15356:16537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59448.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       441..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          105 a          117 c          157 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg catctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttccttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg actgggtggc agttatgtcg
      301 tctgatggaa gtaacaagta ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt ttatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtctttggc ggggggcttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01000967             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18366:2262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000967
VERSION     KCXD01000967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18366:2262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..493
     V_segment       136..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59449.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       443..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          114 c          146 g          119 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttat tgctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gagacttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaccta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtctgatgaa
      301 attaagaaat actacgcaga ctctctgaag gaccgattca ccatctccag agacaattcc
      361 aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattac
      421 tgtgcgaggg aggagagatt tggctacagt tttgacttct ggggccaggg aatcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01000968             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17562:21406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000968
VERSION     KCXD01000968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17562:21406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59450.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          121 c          146 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatgaaac taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000969             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22218:10279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000969
VERSION     KCXD01000969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22218:10279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59451.1"
                     /translation="CVIVGPYHYFDFW"
     D_segment       415..423
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          113 a          140 c          132 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagttggta cagtctgggg ttgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg agaaggactt gagtggatgg gaggtgttca tcctgaattt ggtaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgatag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01000970             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11642:6156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000970
VERSION     KCXD01000970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11642:6156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59452.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       398..412
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          135 c          133 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggcgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat attagtatta gtgggaggac cgactacaac ccctccctca agagtcgagt
      301 caccatttca acagacacgt ccaagaacca gttctccctg aagttgacct ctgtgaccgt
      361 cgcggatacg gccgtgtatt actgtgcgag atatccatat agtgggagct acttcaggta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000971             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13928:18062
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000971
VERSION     KCXD01000971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13928:18062"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59453.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          131 c          136 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tatctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggctat atatatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgtcgcggac acggccgtgt attattgtgc gagttcgggg atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000972             310 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14623:9866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000972
VERSION     KCXD01000972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 310)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 310)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14623:9866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..308
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..308
     V_segment       7..247
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <239..>277
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59454.1"
                     /translation="CARGKYSNSIDFW"
     D_segment       252..261
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       267..308
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        309..>310
                     /gene="IGHG"
BASE COUNT           79 a           73 c           83 g           75 t
ORIGIN      
        1 acatgggaga ctctcctgtg cagcctctgg attcaccttc agaaactttg gcatgcactg
       61 ggtccgccag gccccaggga aggggctgga ttgggtggca gttatgtcgt ttgatgaaaa
      121 tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag acaattccaa
      181 gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccc tgtattactg
      241 tgcgagaggg aaatacagta attctattga cttctggggc cagggagtcc tggtcaccgt
      301 ctcgtcagcc
//
LOCUS       KCXD01000973             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13610:2601
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000973
VERSION     KCXD01000973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13610:2601"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..445
     V_segment       100..386
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59455.1"
                     /translation="CASSDYGWFDVW"
     D_segment       391..399
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..445
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           92 a          123 c          126 g          106 t
ORIGIN      
        1 acatggggtt ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggaatcg
      121 gacccaggag tagtgaagcc ttcggagacc ctgtccctca cctgcgttgt ctctggtggc
      181 gatagttata ggtggagctg gatccgccag cccccaggga agggactgga atggattggg
      241 tatatttatg gtagtattac ggacaccaac tacaacccct ccctcaaaag tcgagtcacc
      301 atttcaaaag acacgtccaa gaagcagttc tccttgaaac tgagctctgt gaccgtcgcg
      361 gacacggccg tgtatttctg tgcgagttca gactacggtt ggttcgatgt ctggggcccg
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000974             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16891:10620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000974
VERSION     KCXD01000974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16891:10620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..356
     V_segment       7..278
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59456.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       287..298
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..356
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           71 a          107 c          104 g           76 t
ORIGIN      
        1 acatgggggc ccaggactgg tgaagccttt ggagaccctg tccctcacct gcgctgtctc
       61 tggtggctcc atcagcagta actactgggc ctggatccgc cagcccccag ggaagggact
      121 ggagtggatt ggacgtatct ctggtagtgg tgggagcacc gtctacaacc cctccctcaa
      181 gagtcgagtc accatttcaa ctgacacgtc caagaaccag gtctccctga aagtgacttc
      241 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaca gccggatata gcagcagcga
      301 aagcttctac ggtttggatt cctggggcca aggggtcgtc gtcatcgtct cctcagcc
//
LOCUS       KCXD01000975             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15217:2670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000975
VERSION     KCXD01000975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15217:2670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59457.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          143 c          152 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgcccg
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgactta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg gggtgttgac cctgcaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgcgatctga ggacacggcc gtttattact gtgcgagagg
      421 gggcttcggt agcagtgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01000976             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12018:7458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000976
VERSION     KCXD01000976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12018:7458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59458.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          134 c          131 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggcttcatca ccaatagtta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ctatctatgg tggtactggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt gtattattgt gcgagatatg aggatgaata cagtgactac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000977             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23025:2962
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000977
VERSION     KCXD01000977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23025:2962"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59459.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       445..455
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          131 c          150 g          117 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatggag tctgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctggaggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtaca gccactggat tcaccttcag tagttttggc
      241 atgagctggg tccgccagcc tccagggaag gggctggagt gggtctcata cattagtaat
      301 agtggtagta gcacatacta cgcagactcc gtgaagggcc gattcaccat ctccagagac
      361 aactcaaaga acacgctctc cctgcaaatg aacagcctga cagctgagga cacggccgtg
      421 tatcactgtg cgaaacatcg tttcagcagc tggtcgtatt tccttgactt ctggggccag
      481 ggaatcctgg tcgccgtctc ctcagcc
//
LOCUS       KCXD01000978             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14165:10800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000978
VERSION     KCXD01000978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14165:10800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59460.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          115 c          154 g          125 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaatacggtt tttctgcaaa tgaattccct gaaaatggag gacacggccg
      421 tgtattactg tgtgagagtc catgactacg ctatgtacta ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000979             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:16992:11349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000979
VERSION     KCXD01000979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:16992:11349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59461.1"
                     /translation="CARELCSSSVCAGAFDYW"
     D_segment       425..430
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          137 c          141 g          106 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccccatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccacctggtg cagtccggga ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg taaggcttct ggattcaccc tggacaacta tggtgttaac tgggtgagac
      241 agacccctgg acaaggactt gagtggatgg gggtgatcat cccccttgtt ggtataatta
      301 attacgcaga gaagttccag ggcacagtca ccattaccgc ggacacgtcc acagacacag
      361 cctacatgga gttcagcagc ctgagatctg aggacacggc catctactat tgcgcgagag
      421 aactttgtag ctctagtgta tgtgccgggg cctttgatta ctggggccag ggagccctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01000980             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:24313:5474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000980
VERSION     KCXD01000980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:24313:5474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..325
     V_segment       152..250
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <244..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59462.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       258..273
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..325
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           73 a          103 c           93 g           58 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggggagag tcaccatgac cgaggacacg
      181 tctacagaca cggcctacat ggagctgagt agcctgagat ctgaggacac gggcgtgtat
      241 tactgtgcga ttggccctag cggcaggtgg aaccactggt ccttcgagat ctggggacct
      301 gggaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01000981             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15082:14456
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000981
VERSION     KCXD01000981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15082:14456"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59463.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          112 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgatcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01000982             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23572:20266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000982
VERSION     KCXD01000982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23572:20266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..515
     V_segment       137..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59464.1"
                     /translation="CAKVDHEDDYGFYYTWSYFDSW"
     D_segment       435..462
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          111 a          127 c          157 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agcactggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 gggatccctg agacttacct gtgcagcctc tggattcacc ttcagtaggt atgccatgca
      241 ctgggtccgc caggctccag acaaggggct ggagtgggtc tcagttatta gtagtggtgg
      301 tagcacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag acaactcaaa
      361 gaccacgctc tccctgcaaa tgaacagcct gagacctggg gacacggccg tgtattactg
      421 tgcgaaagtt gatcacgagg atgattacgg tttctattac acttggagtt actttgactc
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000983             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24020:10245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000983
VERSION     KCXD01000983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24020:10245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59465.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          135 c          130 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga caggtgaggc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaattggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca tgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01000984             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18528:20622
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000984
VERSION     KCXD01000984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18528:20622"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59466.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       434..438
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          123 c          159 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccgtggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat
      241 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      301 tggggatagc acatactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtctc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagtggtgg gtggtgccgc aggatacttc gacttctggg gccagggcgc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01000985             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15760:11598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000985
VERSION     KCXD01000985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15760:11598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59467.1"
                     /translation="CAREYCTTHDCAGFFDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          107 a          132 c          139 g          107 t
ORIGIN      
        1 acatggggaa ccgcatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agttggtgca gtccggggct gaggtcaaga agcctggggc cgcagtgaag gtttcctgca
      181 aggcttctgg attcaccctc gacaactatg gtatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccatgttgg tataataaat tacggtgagc
      301 ggttccagga cagagtcacg attagcgcgg acacgtccat gaatatagcc tacatggacc
      361 tgaccagcct gaaatccgac gacacggcca tctatttctg tgcgagagaa tactgtacta
      421 ctcatgattg cgccggcttc tttgactact ggggccaggg agtcctggtc accgtctctt
      481 cagcc
//
LOCUS       KCXD01000986             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23205:8925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000986
VERSION     KCXD01000986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23205:8925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    2..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        2..336
     V_segment       2..275
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <267..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59468.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       281..286
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..336
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           72 a           81 c          104 g           81 t
ORIGIN      
        1 atgggggagg tttggttcag cctggggggt ccctgagact ctcctgtgca gcctctggat
       61 tcaccttcag tatctctggc atgcactggg tccgccaggc tccagggcag gggctggaat
      121 gggtggcagt tgaatcgttt gatggaggta agaaatacta cgctgactct gtgaaggacc
      181 gattcaccat ctccagagac aattccaaga acatgctata tcttcaaatg aacaacctga
      241 aattggagga cacggccgtg tattactgtg tgagagatgc ctacgggggc ggtttggatt
      301 cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01000987             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:23743:19646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000987
VERSION     KCXD01000987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:23743:19646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..436
     V_segment       85..381
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59469.1"
                     /translation="CSRWGTPFDYW"
     D_segment       382..386
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..436
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           86 a          129 c          126 g           97 t
ORIGIN      
        1 acatgggggg acctcctggg caagaacatg aagcatctgt ggttcttcct cctcctggtg
       61 gcagctccca gatgggtctt gtcccaggtg cagctgcagg agtcgggccc tggactggtg
      121 aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtagctccat caacagtggt
      181 tatgcctgga gctggatccg ccagccccca gggaaggggc tggagtgggt tgggcatatc
      241 tatgatagta gtggaaacac ctactacaac ccctccctca agagtcgagt caccatttca
      301 aaagacacgt ccaagaacca gttctccctg aagttgaatt ctgtgaccgc cgcggacacg
      361 gccgtgtatt actgttcgag atgggggacc ccctttgact actggggcca gggagtcctg
      421 gtcaccgtct cctcagcc
//
LOCUS       KCXD01000988             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:24671:7820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000988
VERSION     KCXD01000988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:24671:7820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..456
     V_segment       99..395
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59470.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       406..410
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           92 a          137 c          128 g          101 t
ORIGIN      
        1 acatggggtc tctgagagtc acggacatcc tgtgcaagaa catgaagcac ctgtggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcagctg caggagtcgg
      121 gcccaggact ggtgaagcct tcggagaccc tgtccctcac ctgtgatgtc tctggtggcg
      181 ccatcagcag tggtttctac tggacctgga tccgccaacc cccagggaag gggctggagt
      241 ggattgggtg tatcggtggt aatagtggta ccacctacta caacccctcc ctcaagagtc
      301 gagccaccat ttcaaaagac acgtccaaca atcaactctc cctgaagctg agttctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagatga agacccctcc atttttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000989             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18507:9723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000989
VERSION     KCXD01000989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18507:9723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59471.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggaggcttg gttcggccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcaatagt tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt gtcagttata tcgtctgatg
      301 aaagtaagaa atattacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caagtgaaca acctgaagct ggaggacacg gccctctatt
      421 actgtgcgag agacgcatat ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000990             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17449:9952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000990
VERSION     KCXD01000990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17449:9952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59472.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          111 a          134 c          157 g          115 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tatgttcaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtagt aatagatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg agacctgagg acacggccgt
      421 gtattactgt gcgtcgaacc tacgtggaaa cacctacact tactggcggt cctttgacta
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000991             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21724:12087
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000991
VERSION     KCXD01000991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21724:12087"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..499
     V_segment       127..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59473.1"
                     /translation="CASGRTHWMELAALMGGLDSW"
     D_segment       420..425
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>507
                     /gene="IGHG"
BASE COUNT          114 a          137 c          153 g          103 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgagatga agaagcctgg ggcctctgtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgagt tttccatgca ctgggtgcga
      241 ctggcccctg gaaaaggact tgagtggatg ggaggtgttg atcctctatc tggtgacata
      301 atacacgcag aaaagttcca gggcagagtc accatgaccg aggacacgtc tgcagacaca
      361 gcctacatgg agctgagcag cctgacatct gaggacacgg ccgtctatta ctgtgcgagt
      421 gggaggacac attggatgga gttggcggcc ttaatgggcg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctt gtcagcc
//
LOCUS       KCXD01000992             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14918:8025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000992
VERSION     KCXD01000992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14918:8025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59474.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       433..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          103 a          123 c          152 g          112 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc gatcagcact
       61 aaacacagaa cacaccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa
      121 aggtgtccat tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa agcctggggg
      181 gtccctaaga ctctcctgtg cagcatccgg attcagcttc agtgaccact gcatgcactg
      241 ggtccgccag gcttcaggga aggggctgga gtgggtctca ggtattactt atactggtgt
      301 taccacatgg tacgcagact ccgtgagggg cagattcacc atctccagag agaacgccaa
      361 gaacacactg tatcttcaaa tggacagcct gagacctgag gacacggctg tctattactg
      421 tgtgggagga aggcggcacg tggaccttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01000993             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18987:16701
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000993
VERSION     KCXD01000993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18987:16701"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59475.1"
                     /translation="CVRDGYGSGLDSW"
     D_segment       441..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          105 c          157 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcggg
      181 gggagtccct gagactctcc tgtgtagctt ctggattcac cttcagcacg tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata acgaatgatg
      301 gaagtaagaa ttactacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaatat gctatacatt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgggtac ggtagtggtt tggattcttg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01000994             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20881:8442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000994
VERSION     KCXD01000994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20881:8442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59476.1"
                     /translation="CANGHWGNGFDYL"
     D_segment       442..448
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          153 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtcg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag actccaggga aggggctgga gtgggtggca gttctttcgt
      301 ctgatggaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tgtatttctg tgcgaacggg cactggggga acggctttga ctacttgggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01000995             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18696:15958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000995
VERSION     KCXD01000995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18696:15958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..511
     V_segment       139..431
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59477.1"
                     /translation="CTSHYSGSYYLDYFDSW"
     D_segment       440..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          118 c          151 g          129 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattccagct gtctccactt ggtgatcagc
       61 actgaacaca ggagactcgc catggagttt gtactgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggcgggtccc tgagactctc ctgtgctgcc tctggattta gtttcggaga ctttgccatg
      241 agttgggtcc gccaggcttc tgggaaagga ctggagtggg ttggctatat tagaagcgta
      301 cataggaatt acgcgacaga atacgccgcg tcggtaaaag gcagatttac catctccaga
      361 gatgattcaa agaacacgct atatttacaa atgagcagcc tgaaaaccga ggacacggcc
      421 gtctatttct gcaccagcca ctatagtggt agttattact tagactactt tgactcctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01000996             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23738:19522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000996
VERSION     KCXD01000996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23738:19522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..356
     V_segment       7..295
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <287..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59478.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       299..311
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..356
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           87 a           83 c          101 g           87 t
ORIGIN      
        1 acatgggcaa ttggtggagt ctggaggagg cttggttcag ccgggggggt ccctgaggct
       61 ctcctgtgca gcctctggat tcaccttcag taattatggc ttccactggg tccgccaggc
      121 tccagtgaag gggctggagt gggttgcagt tatatcgtat gatgaaaatg tgaaattcta
      181 cgcagactct gtaaaggacc gattcaccat ctccagagac aattccaaga acatgctata
      241 tcttcaaatg aacaacctga aattggagga cacggccgtg tattactgta cgagagggga
      301 atacagtaac tctattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01000997             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17494:16094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000997
VERSION     KCXD01000997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17494:16094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59479.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       416..424
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          109 a          140 c          134 g           92 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca actacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attgtccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgacgttcca
      301 gggtagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag
      361 cctgacatct gaggacacgg ccgtgtatta ctgcgcgatt ggccctagtg gcagatggaa
      421 cgactggtcc ttcgacatct ggggacctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01000998             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20627:4683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000998
VERSION     KCXD01000998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20627:4683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59480.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          113 a          143 c          129 g           92 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttccgggta caccttaacc gaccactacc tacactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt attcttcctg agtatggtaa agttgactac
      301 acacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga gacagtctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01000999             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12668:10097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01000999
VERSION     KCXD01000999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12668:10097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59481.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       428..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          115 a          136 c          144 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacagc agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa aaaccttcac tgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatctt gcatatgatg aaataatgga
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cggcgggcct
      421 tgggggatat ttactgcata ctgaatactt cgagttctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01001000             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20695:6660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001000
VERSION     KCXD01001000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20695:6660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59482.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          139 c          136 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001001             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16618:5789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001001
VERSION     KCXD01001001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16618:5789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..516
     V_segment       141..440
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59483.1"
                     /translation="CARGDIVAIEAYYGLDFW"
     D_segment       447..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..516
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          120 a          116 c          157 g          125 t
ORIGIN      
        1 acatggggtg ggagaggaga cccagccttg ggattcccag gcgtctccac ttggtgatca
       61 gcactgaaca caagagactc accatggagt ttgtactgag ctgggttttc cttgttggta
      121 ttttaaaagg tgtccagtgt gaggtgcagc tggaggagtc tgggggagac tgggtccagc
      181 ctggcgggtc cctgagactc tcctgtgcag cctctggatt taccttcagt gactatgcca
      241 tgagttgggt ccgccaggct tctgggaaag gactggagtg gcttggctat attagaagca
      301 aatccaataa ttatgcgaca gaatatgtcg ccccggtgaa aggcaggttc accatctcca
      361 gagatgattc aaagaacacg gtatatctgc aaatgagcag cctgaaaacc gaggacacgg
      421 ccgtgtatta ctgtgctaga ggggatatag tggctataga agcctactac ggtttggatt
      481 tctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001002             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15637:7842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001002
VERSION     KCXD01001002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15637:7842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..500
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59484.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>506
                     /gene="IGHG"
BASE COUNT          118 a          145 c          146 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgattt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gagttgttaa tcctgtaaat ggagaaatga
      301 tacacgcaga gaagttccag gccagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gttggtcagc ctgacatctg aggacacggc catctattac tgtgcgacag
      421 ggaggatcgg tagcagcgtc tggtccagcc tcttcaacgg cttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc gcagcc
//
LOCUS       KCXD01001003             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5255:15133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001003
VERSION     KCXD01001003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5255:15133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59485.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          145 c          150 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacaccg tcagcgaatt gtccatgcac tgggtacgac
      241 aggcccctgg gaaagggctt gagtggatgg gagttgttga tcctgccaat ggtgaagaaa
      301 tacacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtgg acagacacag
      361 cctacatgga cttgaccagt ctcagatctg aggacacggc catctattac tgtgcgacag
      421 ggaggatcgg tagcagcggc tggtccaacc tcttcaccgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001004             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15910:18365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001004
VERSION     KCXD01001004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15910:18365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..478
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59486.1"
                     /translation="CARYGADYEDDYDYYSFDYW"
     D_segment       407..432
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           97 a          137 c          135 g          111 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacttgcgc tgtctctggt
      181 gactccatca ccagtagctt ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatctatgg gagtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtctcca tttcaacaga cacgtccaag aaccagtttt ccctgaatct gaactctgtg
      361 accgccgcag acaccgccgt gtattactgt gcgagatatg gggcggatta cgaggatgat
      421 tacgattact atagttttga ctactggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001005             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:12570:5126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001005
VERSION     KCXD01001005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:12570:5126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59487.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          102 a          144 c          128 g          105 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tcccagccga caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001006             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:11683:9745
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001006
VERSION     KCXD01001006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:11683:9745"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59488.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          110 c          154 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtccggg ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtacagcctc tggattcatg ttcagtaact atggcatcca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg tcagttatat cgtatgatgt
      301 aactgtgaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacacg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ttgtgtgagg gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      481 cgtctcgtca gcc
//
LOCUS       KCXD01001007             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22040:15407
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001007
VERSION     KCXD01001007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22040:15407"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59489.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       444..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          148 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aattggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgagg ctctcctgtg cagcctctgg attcaccttc agtcgctttg
      241 gcttgcactg ggtccgtcag actccagtga aggggctgga gtgggttgca gtaatatcgt
      301 atgatgaaaa tgtgaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacatcct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gagtacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001008             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5962:14400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001008
VERSION     KCXD01001008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5962:14400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59490.1"
                     /translation="CARERCNTRVCAGFFDYW"
     D_segment       426..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          146 c          139 g           95 t
ORIGIN      
        1 acatggggac acaaaacaac cacatccctc ctctaaagaa gcccctggga gcacagctca
       61 tcaccatgga ctggacctgg aggctcccct ttgtggtggc agcagctaca ggtggccagt
      121 cccaggtcca ggtggtgcag tccggggctg aagtgaagaa gcccggggcc tcagtgaaag
      181 tttcctgcaa ggcctctgga ttcaccctcg acaactttgg catcaactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag tgaccatccc ccttgttggg ataattaact
      301 acgcagagaa gtcccagggc agagccacac ttaccgcgga cacgtccaca aacacagcct
      361 acatggaact gaccggcctg atatctgagg acacggccat ctattactgt gcgagagaac
      421 gctgtaatac tcgtgtttgc gccggcttct ttgactactg gggccaggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001009             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:20180:10371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001009
VERSION     KCXD01001009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:20180:10371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..500
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59491.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       422..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          119 a          138 c          143 g          104 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggatt cacgttcagc accgatgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgattg gatgggaggg gtcatccctc ttatgggtac aacaaactac
      301 acacagaagt tccagggcag agtcacgttt accgcggaca cgtcactaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attattgtgc gaaatccgtg
      421 aattacgagg aagataacgg ttactatata ccgacgcagt ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01001010             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17425:11651
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001010
VERSION     KCXD01001010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17425:11651"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59492.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          122 a          137 c          134 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaggtg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctaaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01001011             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:3937:18255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001011
VERSION     KCXD01001011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:3937:18255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59493.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          117 a          143 c          129 g           92 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttccg gatacacctt aaccgaccac tacctacact gggtgcgaca
      241 gactcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgaggagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01001012             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19145:8262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001012
VERSION     KCXD01001012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19145:8262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59494.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          141 c          132 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atccactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001013             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20976:21079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001013
VERSION     KCXD01001013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20976:21079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59495.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          114 a          143 c          129 g           93 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttccgga tacaccttaa ccgaccacta cctacactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtattcttcc tgagtatggt aaagttgact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001014             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16922:16139
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001014
VERSION     KCXD01001014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16922:16139"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59496.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       445..453
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          112 c          154 g          122 t
ORIGIN      
        1 acatgggggt gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcggtta tatcgtttga
      301 tgatagtaag aaatactacg tagactctgt gaaggaccga ttcaccattt ccagagacaa
      361 ttccaagaac atgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgttta
      421 ttactgtgtg agagatgctt acggtagtgg ctgggactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001015             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6428:8483
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001015
VERSION     KCXD01001015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6428:8483"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59497.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          138 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcgg ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggcg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001016             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17288:19565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001016
VERSION     KCXD01001016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17288:19565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59498.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           88 a          139 c          137 g          100 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 gctccttcag cggttactac tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattggcta tatcagtggg agtagtggga gtaccgacta caagtcctcc ctcaacagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagctctc cctgagactg aactctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagtccg gggcgttact atccactact
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001017             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17647:20318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001017
VERSION     KCXD01001017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17647:20318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59499.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          114 c          152 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcacgttca gtaactatgg
      241 aatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaagat aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01001018             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20962:8818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001018
VERSION     KCXD01001018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20962:8818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59500.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       453..460
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          108 a          135 c          154 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gttcaactgg tggagtctgg aggagacttg gtccagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcatacatt agtattggtg
      301 gtggtaccac atcctacgca gactccgtga agggccgatt caccgtctcc agagacaact
      361 cagagaaaac gctctccctg caaatgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgcgtc gaacctacgt ggaaacacct acacttactg gcggtccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001019             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:9497:19002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001019
VERSION     KCXD01001019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:9497:19002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59501.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          131 c          138 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca gggctggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actggagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatccatg ggagtgatag tagtaccaag tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaatcaatgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagtattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001020             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21918:16291
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001020
VERSION     KCXD01001020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21918:16291"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59502.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       401..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           79 a          142 c          139 g          101 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc cccagggaag gggctggagt
      241 ggattgggtt tttcggtggt tatggtggga gcacctacta caacccctcc ctccagagtc
      301 gagtcaccat ttcagccgac acgtccaagc accagttctc cctgatactg acctctgtga
      361 ccgccgcgga cacggccctc tactactgtg cgagggggaa tatagcagcg actggcattg
      421 actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001021             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24608:12083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001021
VERSION     KCXD01001021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24608:12083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59503.1"
                     /translation="CASNSITSGPDYW"
     D_segment       399..405
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          140 c          124 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggcggcag ctcccagatg ggtcctgtcc cgcctgcagc tgcaggcgtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgc
      181 ctctatcagc ggtaactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggatat atctatggta gtgatattag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagttctcc ctgaacctgg cctctgtgac
      361 cgccgcggac acggccatct atttctgtgc cagtaacagt ataacatctg gtccagacta
      421 ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001022             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14405:17749
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001022
VERSION     KCXD01001022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14405:17749"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59504.1"
                     /translation="CTRYVYGSGFDYW"
     D_segment       444..452
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          114 c          153 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctactttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcctggtt
      181 cagcctcggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtttt
      241 ggcatgcact gggtccgaca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 tctgacggaa gtaggatata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaatttca agaacatgct atatcttcaa atgaacaacc tgaaatttga ggacacggcc
      421 gtgtattatt gtacgagata tgtctacggt agtggatttg actactgggg cctgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001023             436 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15126:11505
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001023
VERSION     KCXD01001023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15126:11505"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    68..434
                     /note="immunoglobulin heavy chain variable region"
     V_region        68..434
     V_segment       68..359
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <353..>403
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59505.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       373..379
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..434
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        435..>436
                     /gene="IGHG"
BASE COUNT          104 a          115 c          127 g           90 t
ORIGIN      
        1 acatgggacc atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc
       61 ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaaggctg gggcctcagt
      121 gaaggtctcc tgcaaggttt ccggatacat cttaaccgaa ttatccatac actgggtgcg
      181 acaggcccct ggaaaagggc ttgagtggat gggaagtctt gatcctcaat atggtgaaat
      241 gatagacgca gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac
      301 agcctacatg gagctgagca gtctgagatc tgaggacacg gccgtgtatt actgtgcgac
      361 atcatccagc ggcacctggc tatactggta cttcgatatc tggggccctg gcaccccaat
      421 caccatctcc tcagcc
//
LOCUS       KCXD01001024             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7179:13091
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001024
VERSION     KCXD01001024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7179:13091"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..444
     V_segment       81..374
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <366..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59506.1"
                     /translation="CARDRRVKSLSWFDVW"
     D_segment       388..393
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..444
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT           89 a          105 c          141 g          111 t
ORIGIN      
        1 acatggggaa cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc
       61 ttttgaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcagagc
      121 ctggggggtc cctgagactc tcctgcgcag cctctggatt cagtttcagt tactactaca
      181 tgagctgggt ccgccaggct ccagggaagg ggctggagtg gatctcaact attaacagtg
      241 gtgggggtag tacatactat gcagactccg tgaagggcag attcaccttc tccagagaga
      301 acgccaagaa cacactgtct cttcaaatgg acggcctgag agctgaggac tcggctgtct
      361 atttctgtgc gagagatcga cgtgtaaagt cgttatcctg gttcgatgtc tggggcccgg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001025             297 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7939:12520
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001025
VERSION     KCXD01001025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 297)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7939:12520"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..291
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..291
     V_segment       7..202
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <196..>264
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59507.1"
                     /translation="CATGVYYQDEHGYFYVGGDFDYW"
     D_segment       211..224
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..291
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        292..>297
                     /gene="IGHG"
BASE COUNT           68 a           73 c           90 g           66 t
ORIGIN      
        1 acatgggcca tcagttgggt gcgacaggcc cctggacaag ggcttgggtg gatgggaggg
       61 atcatccctc ttgttggtat gacaaactac gaacagaagt tccagggcag agtcacgatt
      121 accgcggaca cgtccacgaa tacagtcttc atggaactga gcagcctgag atctgaggac
      181 acggccgtct actattgtgc gacaggggta tattaccagg atgaacacgg ttatttttat
      241 gtcggcggtg actttgacta ctggggccag ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01001026             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:11582:12155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001026
VERSION     KCXD01001026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:11582:12155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..328
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59508.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       265..285
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           77 a           73 c           97 g           83 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg actgggtgac agttatatcg
      121 tatgatggaa gtacgaagta ctatgtagac tctgtgaagg accgattcac catctccaga
      181 gacaattcga agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtgtattatt gtgtgagagt agactgtagt ggtggtgtct gctactttga ctactggggc
      301 cagggagtcc tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01001027             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13154:6821
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001027
VERSION     KCXD01001027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13154:6821"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    150..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        150..458
     V_segment       150..385
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59509.1"
                     /translation="CVRLQSSHYYTFGFHSW"
     D_segment       399..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..458
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT          109 a          113 c          124 g          114 t
ORIGIN      
        1 acatggggga gctctgggag aggagaccca gccttgggat tcccaggcgt ctccacttgg
       61 tgatcagctc tgaacacaag agactcacca tggaatttgt actgagctgg gttttccttg
      121 ttgctatttt aaaaggtgtc cagtgtgacg tgcagcctct ggattcacct tcagtgacta
      181 tggcatgagc tgggtccgcc aggcttctgg gcaaggactg gagtgggttg gctatattag
      241 aagcaaatct aacaattacg cgacagaata cgccgcatcg gtgaaaggca ggttcgccat
      301 ctccagagat gattcaaaga atacgctata tctgcaaatg agcagtctga aaaccgagga
      361 cacggccgtc tattactgtg tgagactcca gtccagtcac tattacactt tcggtttcca
      421 ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001028             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4595:6118
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001028
VERSION     KCXD01001028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4595:6118"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..512
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59510.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       459..466
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>518
                     /gene="IGHG"
BASE COUNT          112 a          132 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggtcc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggtggtag taatagatat tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacaccct gagacctgag gacacggccg
      421 tgtattactg tgcgtcgaac ctacgtggaa acacctacac ttactggcgg tcctttgact
      481 actggggcca gggagtcctg gtcaccgtct ccgcagcc
//
LOCUS       KCXD01001029             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6389:15440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001029
VERSION     KCXD01001029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6389:15440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..488
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59511.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          156 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgaa gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtggc tctggcatgc
      241 actgggtccg ccagtctcca gggaaggggc tggaatgggt ggcggttata tcgaatgatg
      301 gaactaagaa atactacgcg gactctgtga aggaccgatt cagcatttcc agagacaact
      361 ccaagaacat gctgtatctt caaatgaaca acctgaaagt ggaggacacg gccgtctact
      421 tctgtgcgac agatgcgttt ggtagcggga ttgactactg gggtcgggga gtcctggtca
      481 ccgtctccac agcc
//
LOCUS       KCXD01001030             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:25741:5506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001030
VERSION     KCXD01001030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:25741:5506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59512.1"
                     /translation="CATADYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc caaagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggta ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag tatggaattc tatggagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaag tgaacaacct gaaattggag gacactgccg
      421 tttattactg tgcgacagcc gactacggta acagccttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01001031             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10356:12446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001031
VERSION     KCXD01001031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10356:12446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59513.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          117 c          150 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccctctt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg gctccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tatgatgaaa gtaagaaata ctacgcagac tctctgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgcaattgga ggacacggcc
      421 gtatattact gtgcgagaga tgataatggg gtgcttatcg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001032             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9473:8239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001032
VERSION     KCXD01001032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9473:8239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59514.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          124 c          156 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagtctc tggattcagt ttcagtcact acttcatgag
      241 ctgggtccgc cagactccag ggaagggact ggagtggatc tcagtgatta acagtggtgg
      301 agataccaca cactatgcag actccgtgaa gggcagattc accatgtcca gagagaacgc
      361 caggaacaca ctgtctcttc aaatggacgg cctgagacct gaggactcgg ctgtctatta
      421 ctgtgcgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001033             391 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17111:15239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001033
VERSION     KCXD01001033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 391)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 391)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17111:15239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    35..389
                     /note="immunoglobulin heavy chain variable region"
     V_region        35..389
     V_segment       35..325
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <320..>358
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59515.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       331..337
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       347..389
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        390..>391
                     /gene="IGHG"
BASE COUNT           90 a           95 c          114 g           92 t
ORIGIN      
        1 acatggggtt gccattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg
       61 aggcttggtt cagccggggg ggtccctgag actctcctgt gcagcctctg gattcatctt
      121 cagtacctat gccatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc
      181 agttatttcg catgatgaaa ctaagagata ctacacagac tctgtgaagg accgattcac
      241 catctccaga gacaattcca agaacataca atatcttcac atgaacaacc tgaaattgga
      301 ggacacggcc atatactact gtgcggcctc ctacttgggg tacggatttg agtactgggg
      361 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001034             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22815:17056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001034
VERSION     KCXD01001034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22815:17056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59516.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          109 c          155 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaaacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001035             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20526:20194
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001035
VERSION     KCXD01001035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20526:20194"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..461
     V_segment       92..385
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59517.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT          100 a          123 c          143 g           97 t
ORIGIN      
        1 acatgggaga agccccagag cacagcacct caccatggac tggacctgga ggatcctcct
       61 cttggtggca gcagctacag gcgcccactc tgaggtccag ctggtgcagt ctggggctga
      121 agtgaagaag cctggggcct cagtgaaggt ctcctgcaag gttttcggat acaccttcag
      181 cgatttatcc atgcactggg tgcgacaggc ccctggaaaa gggcttgagt ggatgggagg
      241 tgttgacact gtctctgacg gagtgatata cgcagagaac ttccagggca gagtcgccat
      301 gaccgaggac acgtctacag acacagccta catggaattg agcagcctga gatctgagga
      361 cacggccgtt tattactgtg cgagaggttt atcaccagac gtcttcggtt tcctcgggct
      421 tggctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001036             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14216:3667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001036
VERSION     KCXD01001036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14216:3667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59518.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          144 c          136 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgattt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggccg tgtattactg tgcgactggc cctagcggca
      421 cctggaacgc ctggtacctc gaaatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01001037             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21679:18817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001037
VERSION     KCXD01001037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21679:18817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..475
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59519.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       422..427
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          110 a          136 c          138 g           93 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacagcttc aacatcgatg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcatcc ctcttgtcgg tataacaaac
      301 tacgcacaga ggttccaggg cagagtctcg attaccgcgg acacgtccac aagcacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattactg tgcgatccaa
      421 gggaacagcc agtttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001038             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14423:18734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001038
VERSION     KCXD01001038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14423:18734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59520.1"
                     /translation="CATHGEYRGIWNSLYYGFDFW"
     D_segment       428..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          122 a          143 c          140 g          101 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgattt atccatccac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgtagat ggtgaaataa
      301 tacacgcaga caacttccag ggcagagtcg ccatgaccga ggacacgtct acagacacag
      361 cctacatgga acttaccagc ctgagatctg aggacacggc cgtgtattac tgtgcgaccc
      421 acggagagta tagaggcatc tggaactccc tatactatgg tttcgatttt tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001039             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17879:8285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001039
VERSION     KCXD01001039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17879:8285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59521.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       420..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          116 a          137 c          139 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg atgcgacagg
      241 cccctggaaa agggcttgag tgggtggggg gtgttgatcc tgaatatggt gaaatgacac
      301 acgtagagaa attccagggc agagtcacct tgaccgagga catgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtatttctgt gcagccggat
      421 atagtggcag ctggaactcc tggtacttcg atttctgggg tcctggcacc gcaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001040             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:25135:5668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001040
VERSION     KCXD01001040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:25135:5668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59522.1"
                     /translation="CASGGYEDDSGFYFPDFFDSW"
     D_segment       416..435
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          134 c          145 g          114 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgtc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggctgc tggatacatc tttagtatct ctgccatcag ttgggtgcga caggcccctg
      241 gacagggact tgagtggatg ggagggatca tccctcttgt tggtgtaaca aataacgcac
      301 ggaagttcca gggcagagtc acgattaccg cggacacgtc cacaagcaca gccttcatgg
      361 atctgagcag cctgagatct gaggacacgg ccgtctatta ttgtgcgagc ggtggttacg
      421 aggatgattc cggtttttat tttccagact tctttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001041             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:2738:13548
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001041
VERSION     KCXD01001041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:2738:13548"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59523.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          124 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agtctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccgccagg ctccagggaa gggactggag tggatctcag ggattaacag
      301 tggtggagat accacacact atgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccaag aacacactgt cccttcaaat ggacggcctg agagctgaag actcggctgt
      421 ctattattgt gcgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001042             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12794:20531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001042
VERSION     KCXD01001042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12794:20531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59524.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          128 a          143 c          131 g           90 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcgac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagattc accgaatcat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga atggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacacagaga aattccagga cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggatc tgagcaccct gagatctgac gacacggcca tatattactg tgcgagagcc
      421 catagcggca gctggaataa ctggtacttc gatctctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001043             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14938:5583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001043
VERSION     KCXD01001043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14938:5583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59525.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agttcgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taagaaatac tacgcaaact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatactc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatatgggga ccggttttga ctactggggc cagggagtcc
      481 tggtcatcgt ctcctcagcc
//
LOCUS       KCXD01001044             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17036:12049
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001044
VERSION     KCXD01001044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17036:12049"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..454
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59526.1"
                     /translation="CARWEAADFDFW"
     D_segment       407..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>460
                     /gene="IGHG"
BASE COUNT           90 a          129 c          140 g          101 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgagt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcaatggtga agccttcgga gaccctgtcc ctcacctgcg ctgtgtctgg
      181 tggctccatc agcggtggtt atggctggag ttggatccgc caggccccag tgaagggact
      241 ggagtggatt gggactatgt atggttacag tggtagcacc cactacaacc cctccctcaa
      301 gagtcgagtc accatttcga aagacacgtc caagaaccag ttctccctga aggtgatctc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga tgggaggcag cggactttga
      421 cttctggggc cagggagtcc tggtcaccgt ctccgcagcc
//
LOCUS       KCXD01001045             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16086:6991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001045
VERSION     KCXD01001045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16086:6991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..495
     V_segment       105..398
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59527.1"
                     /translation="CARDAGYGDTILVVDINMFPHFDYW"
     D_segment       416..439
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          138 c          137 g          117 t
ORIGIN      
        1 acatggggaa atcctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctgctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgt gatgtctctg
      181 gtgcctccat cagtagttac tggtggacct ggatccgcca gtccccaggg aagggactgg
      241 aatggattgg ggagatcaat ggtaatagtg gtagtattta ctacaacccc tccctcaaca
      301 gtcgagtcac catttcaaaa gacgcgtcca agaaccagtt ctccctgaag ctgagctctg
      361 tgaccgccgc ggacacggcc gtatatttct gtgcgagaga tgccggctat ggggatacga
      421 tattagtcgt cgatattaat atgttccccc actttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001046             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14249:8727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001046
VERSION     KCXD01001046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14249:8727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59528.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          116 c          154 g          120 t
ORIGIN      
        1 acatggggag cgctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg cttcaccttc aattcctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcgc
      301 atgatgaaac taagaaatac tacgcagact ctgtgaaaga ccgattcagc atctccagag
      361 acaattccaa gaacatggtc tatcttcaaa tgaacaacct gagattggag gacacggccg
      421 tctattactg tgtgagagat gcgtttggta gcgggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001047             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14865:14180
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001047
VERSION     KCXD01001047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14865:14180"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59529.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          143 c          128 g           93 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttccggat acaccttaac cgaccactac ctacactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tattcttcct gagtatggta aagttgacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001048             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11959:19506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001048
VERSION     KCXD01001048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11959:19506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59530.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       428..435
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          123 c          147 g          106 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagtgtcac cgaattatcg attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aagaaattca
      301 cggagaggag ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagttg agcaacctga gatctgagga cacggccgtg tattactgtg cgagtgggtt
      421 tagtatttgg ttattttacg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001049             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22956:20387
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001049
VERSION     KCXD01001049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22956:20387"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59531.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          116 c          160 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc catccggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctccgg attcaccttt agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatatcgt
      301 atgatggaaa taagaaatac tacgcagact ctgtgaggga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001050             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13434:11326
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001050
VERSION     KCXD01001050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13434:11326"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..475
     V_segment       106..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59532.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       406..416
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           98 a          140 c          136 g          103 t
ORIGIN      
        1 acatggggga aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactgct gaagcctttg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tcagcagtaa ctactggagc tggatccgcc agtccccagg gaagggactg
      241 gagtggattg gacgtatctc tggtagtggt gggaacaccg tctacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccaga tctccctgaa agtgacctct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgacag ccggatatag cagcagggaa
      421 agcttctacg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001051             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:20146:6424
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001051
VERSION     KCXD01001051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:20146:6424"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59533.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       442..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          112 c          151 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctatggcatc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgacagttat atcgtatgat
      301 gaaacaaaga aattctacgc agactctctg aaggaccgct tcatcatctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaat aacctgaaat tagaggacac ggccgtatat
      421 ttctgtgtga gagatgtcag gggaacgggg tttgacttct ggggccaggg tgtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001052             411 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13370:14890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001052
VERSION     KCXD01001052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 411)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 411)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13370:14890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    55..409
                     /note="immunoglobulin heavy chain variable region"
     V_region        55..409
     V_segment       55..348
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <340..>378
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59534.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       361..367
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..409
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        410..>411
                     /gene="IGHG"
BASE COUNT           93 a           90 c          125 g          103 t
ORIGIN      
        1 acatgggggc tgagctgggt tttccttgtt gctgttttaa gaggtgtcca gtgcgaggtg
       61 cagctggtgg agtctggagg agacttggtt cagcctgggg ggtccctgag actctcctgt
      121 gcagcctctg gattcacctt cagtaactat ggcatacact gggtccgcca ggctccaggg
      181 aaggggctgg agtgggtggc agttatatcg tctgatggaa gtaagacata ctacgcaaac
      241 tctgtgaagg accgattcac catattaaga gacaattcca agaatatgct atatcttcaa
      301 atgaacaacc tgaaattgga ggacacggcc gtctattact gtgcgagaga cgatttggga
      361 agtggctttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001053             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18965:18711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001053
VERSION     KCXD01001053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18965:18711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59535.1"
                     /translation="CARDVWGRGFDFW"
     D_segment       439..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          112 c          159 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgcg gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaact aagaagtatt atgcagactc tgtgaaggcc cgattcaccg tctccagaga
      361 caattccaag aacatgttat atcttcaaat ggacaacctg aaattggaag acacggccgt
      421 gtattattgc gcgagagatg tctgggggag gggatttgac ttttggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001054             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23237:13975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001054
VERSION     KCXD01001054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23237:13975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59536.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          147 c          131 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct aaagtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca agattaccgg atacaccttc accgatttgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgacc ctgcatttgg tgaaatgacg
      301 ttccagtgca gagtcacctt gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga catctgagga cacggccgtc tattactgtg cgattggccc tagcggcagc
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001055             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18716:9758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001055
VERSION     KCXD01001055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18716:9758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59537.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          114 a          141 c          129 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agttggtaca gtctggggtt gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc agtcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg taaagtagac
      301 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga cttctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001056             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23493:7523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001056
VERSION     KCXD01001056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23493:7523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..497
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59538.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       428..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          117 a          144 c          145 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgatttatc cattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag ttgttaatcc tgtaaatgga gaaatgatac
      301 acgcagagaa gttccaggcc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagtt ggtcagcctg acatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtag cagcgtctgg tccagcctct tcaacggctt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctccgca gcc
//
LOCUS       KCXD01001057             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19879:12264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001057
VERSION     KCXD01001057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19879:12264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59539.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          118 c          153 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtcacttt
      241 ggcttacact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatctcg
      301 catgatggca ataacatata ctacgcagac tctatgaagg accgattcac catctccaga
      361 gacaattcga agaacatggt atatcttgaa atggacaacc tgcaattgga tgacacggcc
      421 gtgtatttct gtgtgagaga tgcctacggt accgggttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001058             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22846:19106
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001058
VERSION     KCXD01001058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22846:19106"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59540.1"
                     /translation="CVTSSSGTWLYWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          142 c          135 g           99 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aagatttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgaaattat
      301 aaattcagag aggttccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga agacacggcc gtgtattatt gtgtgacctc
      421 atccagcggc acctggctat actggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001059             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22751:9113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001059
VERSION     KCXD01001059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22751:9113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59541.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          133 c          137 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatatttgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagtgct ccctgaggct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001060             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:3957:20053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001060
VERSION     KCXD01001060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:3957:20053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59542.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       444..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          115 c          152 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag gcctggaagt ccacagtgtc ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttttt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggct
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cgctactagt
      241 ggcatgcact gggtccgcca gactccaggg aaggggctgg agtgggtggc tgttaaatcg
      301 catgatggaa ataacaaata ctatgcagac tctgtgaagg accgtttcac catctccaga
      361 gacaattcca aaaacatgct atatcttcaa atgaacaacc tgaaattgga ggatacggcc
      421 atttattatt gtgtgagaga tgcctacggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001061             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17646:17264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001061
VERSION     KCXD01001061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17646:17264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59543.1"
                     /translation="CARDRRVESLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          102 a          126 c          157 g          123 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagtttca gttactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtgggggt aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaactccaag accacactgt atcttcacat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gcaagagatc gacgtgtaga gtcgttatcc tggttcgatg tttggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001062             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:15693:10985
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001062
VERSION     KCXD01001062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:15693:10985"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..471
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59544.1"
                     /translation="CARKFEYKKSLDVW"
     D_segment       414..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..471
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT          107 a          128 c          138 g          100 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca atccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attccccttc aacatctatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatgggg cggatcattc ctcttggtga tataacaaat tacgctcaga
      301 agttccagga cagagtcacg attaccgcgg acacgtccac aggcacggcc tacatggagc
      361 tgcgaagcct gagatctgag gacacggccg tgtattattg tgcgagaaaa ttcgaataca
      421 agaagtcatt ggatgtctgg ggccggggag ttctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001063             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16892:18107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001063
VERSION     KCXD01001063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16892:18107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59545.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       442..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          114 c          159 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ccggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcactgata tcgtatgatg
      301 gaagtaagaa atattacgca gacactgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tttgtgcgag agttggagag ggtactggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001064             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22979:8342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001064
VERSION     KCXD01001064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22979:8342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59546.1"
                     /translation="CVRDVRGTGFDFR"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcacgatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtcgggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actacctatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaac aaagaaatac tacgcagact ctctgaagga ccgcttcatc atctccagag
      361 acaattccaa gaatatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gttaggggaa cggggtttga cttccggggc cagggtgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001065             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12367:8509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001065
VERSION     KCXD01001065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12367:8509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..428
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59547.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       442..446
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          104 a          126 c          151 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggaatctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcatc cggattcacc ttcagtgacc actgcatgca
      241 ctgggtccgc caggcttcag ggaaggggct ggagtgggtc tcaggtatta cttatactgg
      301 tgttaccact tgggacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc acatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgtgaca ggaaggcgac acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001066             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:26121:7556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001066
VERSION     KCXD01001066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:26121:7556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59548.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       445..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          116 c          149 g          125 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggta caattggtgg agtctggagg aggtttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagtttctg gattcacctt cagtaactat
      241 gccatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgtaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcta acaacatgct atatcttcaa atgagcaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgcgaggcg cccttggaac gctgactact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001067             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9478:11233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001067
VERSION     KCXD01001067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9478:11233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59549.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       417..428
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          139 c          137 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga agaaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgaatatggt gaaatgatgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 gcagcctgag atctgaggac acggccgtct attactgtgc gattggccct agtggcagct
      421 ggaacgactg gtccttcgac atttggggac ctggcacccc aatcaccgtc tcctcagcc
//
LOCUS       KCXD01001068             342 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6500:15876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001068
VERSION     KCXD01001068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 342)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 342)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6500:15876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    3..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        3..340
     V_segment       3..273
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <265..>309
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59550.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       274..278
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..340
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>342
                     /gene="IGHG"
BASE COUNT           75 a           89 c          107 g           71 t
ORIGIN      
        1 atgggcggct tggcaaagcc tggggggtcc ctgagactct cctgcgcagc ctctggattc
       61 aacttcaatt actactacat gaactgggtc cgccaggctc cagggaaggg gctggagtgg
      121 atctcaggta ttaacagtgg tggggagagc acatactatg cggactccgt gaagggcaga
      181 ttcaccatct ccagagagaa cgccaagaac acactgtatc ttcaaatgga cagcctgaga
      241 gctgaggaca cggctgtcta ttactgtgcg agagtggtgg gtggtgccgc aggatacttc
      301 gacttctggg gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001069             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14401:10746
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001069
VERSION     KCXD01001069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14401:10746"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59551.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          126 c          156 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca aaccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag tttctactac
      241 atgagctggg tccgccagcc tccagggaag ggtctggagt ggatctcagg tattaacgct
      301 ggtggggatg gcacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tatttctgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001070             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:27167:14606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001070
VERSION     KCXD01001070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:27167:14606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59552.1"
                     /translation="CAIGPSGRWNAWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          143 c          137 g           94 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagcttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa gaggccttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgta tattattgtg cgatcggccc tagcggcagg
      421 tggaacgcct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001071             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18710:10183
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001071
VERSION     KCXD01001071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18710:10183"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59553.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       431..439
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          143 c          144 g           97 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcggctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatccatg gcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tttaacacac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgcccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggcct tttattactg tgcgagaggg acaacccacc
      421 tcgagatggc aactggaatc ggagactact ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001072             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:16389:17557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001072
VERSION     KCXD01001072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:16389:17557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59554.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       421..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          108 a          141 c          147 g          108 t
ORIGIN      
        1 acagggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tctcaggtcc agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag
      181 ctctcctgta aggcttctgg atacagcttc agcatctatg tcatcagttg ggtgcgactg
      241 gcccctggac aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc
      361 tacatggacc tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt
      421 tactgtactg gcaatggttg taaccttact ttcaaccggc tcgatgtctg gggcccggga
      481 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01001073             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13422:8992
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001073
VERSION     KCXD01001073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13422:8992"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59555.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          143 c          142 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcatctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtccacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggcttg gattcttggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001074             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23398:4009
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001074
VERSION     KCXD01001074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23398:4009"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59556.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       428..440
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          111 a          114 c          143 g          119 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagt tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcaga aactatggcc tgcactgggt
      241 ccgccaggcc ccagggaagg ggctggattg ggtggcagtt atgtcgtttg atgaaaatgt
      301 gaaattctac gcagactctg tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 catgctatat cttcaaatga acaacctgaa attggaggac acggccctgt attactgtgc
      421 gagaggggaa tacagtaact ctattgactt ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001075             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14478:2928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001075
VERSION     KCXD01001075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14478:2928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59557.1"
                     /translation="CARGPSTIFGILVTGLDYW"
     D_segment       424..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          118 a          139 c          138 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattctcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggggg tgttgatcct ttatacaatg aaataatgta
      301 cgcagacaac ttccagggca gagttaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctga cctctgagga cacggccatg tattactgtg cgcgtgggcc
      421 tagtacaatt tttggaatac ttgttacggg actggactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001076             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18259:3517
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001076
VERSION     KCXD01001076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18259:3517"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59558.1"
                     /translation="CATSSSGTWLYWSFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          123 a          141 c          133 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 cgctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgaaaga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagtctga gatctgacga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtccttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001077             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22892:10456
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001077
VERSION     KCXD01001077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22892:10456"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59559.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          136 c          129 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctatcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001078             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20603:16455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001078
VERSION     KCXD01001078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20603:16455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59560.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          116 a          143 c          128 g           89 t
ORIGIN      
        1 acatgggaca cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttctggatac accttaaccg accactacct gcactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggtg ttcatcctga atatgggaaa gtagactaca
      301 cacagaagtt ccaagacaga gtcaccatca ccgcggacat gtcgacagag acagtctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccactta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgactac tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001079             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17980:15296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001079
VERSION     KCXD01001079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17980:15296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59561.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          122 c          146 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001080             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9865:20434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001080
VERSION     KCXD01001080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9865:20434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59562.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       414..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          118 a          141 c          133 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagga gcctggggcc tcagcgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagttgag cagcctaaga tctgaggaca cggccctgta ttattgtgca gtcgggtata
      421 gcggccgatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01001081             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16183:9436
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001081
VERSION     KCXD01001081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16183:9436"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59563.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          113 c          154 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcattcact gggtccgcca gactccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagacata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt gtattttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgtgagaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001082             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8438:15448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001082
VERSION     KCXD01001082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8438:15448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59564.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          114 a          124 c          149 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtgtct ggttatttaa cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001083             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18248:18874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001083
VERSION     KCXD01001083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18248:18874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59565.1"
                     /translation="CARSQSYCRGLYCYGYYYFDFW"
     D_segment       406..429
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           96 a          145 c          134 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcaa ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctatcacc agtactaagt ggtggagctg gatccgccag ccaccaggga aagggctgga
      241 gtggatcggg tatattagtg gtagcagtgg taccacctac taccacccct ccctcaagag
      301 tcgagtcagc atttcaacag acacgtccaa gaaccagttc tccctggagc tgcactctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatcc caatcatatt gtcgtggtct
      421 ttactgctac ggctactact actttgactt ctggggccag ggagtccagg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001084             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19426:7866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001084
VERSION     KCXD01001084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19426:7866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..376
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59566.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       387..392
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           98 a          101 c          136 g          106 t
ORIGIN      
        1 acatgggcag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctattttaa gaggtgtcca ctgtgaagtg cagctggtgg agtctggagg aggcttggtt
      121 cagccggggg ggtccctgag actctcctgt gcagtctctg ggttcacctt cagtggctct
      181 ggcatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc ggttatatcg
      241 aatgatggaa ctaacaaata ctacgcagac tctctgaagg accgatttag tatctccaga
      301 gagaattcca agaacatgct atatcttcaa atgaacaacc tgaaactgga ggacacggcc
      361 gtctattact gcgcgacaga tgcgtttggt agcgggattg actactgggg ccggggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001085             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21857:2377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001085
VERSION     KCXD01001085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21857:2377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..403
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59567.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       415..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          116 a          139 c          141 g          101 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgcggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg gttcaccttt agcaccgaag ccatcaattg ggtgcgacag gcccctggac
      241 aaggacttga ctggatggga ggggtcatcc ctcttatggg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg tttaccgcgg acacgtccat aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattattg tgccaaatcc gtgaattacg
      421 aggaagataa cggttactat ataccgacgc agtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01001086             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10183:16087
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001086
VERSION     KCXD01001086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10183:16087"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59568.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       447..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          112 a          126 c          150 g          126 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgaac tgggttttcc ttgttgctat
      121 cttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcgatg aatatggctt
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg gttggctata ttagaagcca
      301 atacaggaat tacgcgacag aatacgccgc atcggtgaaa ggcagattct ccatctccag
      361 agatgattca aagaacacgc tttatctaca aatgagcagc ctgacaaccg aggacacggc
      421 cgtctattat tgcaccaccc tctatggtgg tagttattac gtggactact ttgactcctg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001087             442 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12724:16568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001087
VERSION     KCXD01001087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12724:16568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..440
     V_segment       71..362
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <356..>409
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59569.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       381..390
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>442
                     /gene="IGHG"
BASE COUNT           88 a          135 c          126 g           93 t
ORIGIN      
        1 acatgggaag aacatgaagc acctgtggct cttcctcctg ctggtggcag ctcccagatg
       61 ggtcctgtcc caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cctcagagac
      121 cctgtccctc acctgcgctg tctctggtgc ctccatcggt agttactggt ggacctggat
      181 ccgccagccc ccagggaagg gactggagtg gattggggag atcaatggaa atagtggtag
      241 tacctactat agcccctccc tcaagagtcg agtcaccatt tcaaaagacg cgtccaagaa
      301 ccacctctcc ctgaagctga actctgtgac caccgcggac acggccgtgt atttctgtgc
      361 gaacgtctta ggcccctggg gcagctggtc acactacttt gactactggg gccagggagt
      421 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001088             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8458:6284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001088
VERSION     KCXD01001088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8458:6284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59570.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       402..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..474
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           97 a          135 c          135 g          109 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 gctccttcag cggttactat tggagctgga tccgccagtc cccagggaag gggctggagt
      241 ggattgggta tatcagtgct agtagtggga gtaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaatt accatttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgagagagaa gtactatagt ggtagttata
      421 aacacaactg gttcgatgtc tggggcccgg gagtccaggt caccgtctcc tcagcc
//
LOCUS       KCXD01001089             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11655:16674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001089
VERSION     KCXD01001089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11655:16674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59571.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          115 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctactttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctcggg attcaccttc agtagctttg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattcgag gactatggta tatcttcaaa tgaacaacct gaaactggag gactcggccg
      421 tgtattactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001090             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17275:4361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001090
VERSION     KCXD01001090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17275:4361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59572.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          120 a          144 c          134 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatccact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 cctctcctca gcc
//
LOCUS       KCXD01001091             408 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:6069:14431
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001091
VERSION     KCXD01001091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 408)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 408)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:6069:14431"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    235..406
                     /note="immunoglobulin heavy chain variable region"
     V_region        235..406
     V_segment       235..345
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <337..>375
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59573.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       354..360
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       367..406
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        407..>408
                     /gene="IGHG"
BASE COUNT           93 a           93 c          123 g           99 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttatgacgct
      241 gtgaaggacc gattcaccat ctccagagac aattccaaga acatgctata tcttcaaatg
      301 aataacctga aaatggagga cacggccgtg tattactgtg ggagagatga taatggggtg
      361 cttatcgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001092             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10624:3440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001092
VERSION     KCXD01001092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10624:3440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59574.1"
                     /translation="CARSRGVLLPYFDFW"
     D_segment       406..411
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           88 a          137 c          134 g          106 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagttgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggttccatca gcagtatcta ctggagctgg ttccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tagtagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcgacaga cacgtccaag aggcagttct ccctgaagct gaactctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagaagca ggggggtact tctcccctac
      421 tttgacttct ggggccaggg agtcctggtc accgtttcct cagcc
//
LOCUS       KCXD01001093             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:21286:4579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001093
VERSION     KCXD01001093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:21286:4579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..500
     V_segment       128..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59575.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       427..441
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          143 c          145 g          103 t
ORIGIN      
        1 acatggggga gagcatcaca caacaaccac atccctcccc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc
      121 ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaaggtctcc tgcaaggttt ccggatccac cttcaccgaa ttatccatac actgggtgcg
      241 gcaggcccct ggaaaagggc ttgagtggat gggaggtgtt gctcctctat atggtgaaat
      301 gatgctcgca gacaacttcc agggcagagt caccttgacc gaggacacgt ctacagacac
      361 agcctacatg gagctgagca gcctgagatc tgacgacacg gccgtgtatt actgtgcgcg
      421 tgggcctatt acaatttttg gcgtacttat tacggggctt gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001094             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15225:14398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001094
VERSION     KCXD01001094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15225:14398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59576.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          116 c          152 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgtcc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaagt ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa cagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001095             372 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16480:7876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001095
VERSION     KCXD01001095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 372)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 372)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16480:7876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    3..370
                     /note="immunoglobulin heavy chain variable region"
     V_region        3..370
     V_segment       3..297
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <289..>339
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59577.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       308..322
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       329..370
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        371..>372
                     /gene="IGHG"
BASE COUNT           79 a           93 c          111 g           89 t
ORIGIN      
        1 atggggcagt tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc
       61 tcctgtgcag cctctggatt caccttcagt gactactgga tgtactgggt tcgccagaca
      121 cctgagcagg gtctggaatg gatctcagct attgatagtg ctggtactag taccacatac
      181 tatgcagact ccgtgaaggg cagattcacc atctccagag agaacgccaa aaacacactg
      241 tatcttcaga tggacagcct gagaactgag gacacggctg tctattactg tgcgagagtt
      301 ccgggcctag tggtatttac tggttcgctt gactactggg gccagggagt cctggtcacc
      361 gtctcctcag cc
//
LOCUS       KCXD01001096             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8827:11346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001096
VERSION     KCXD01001096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8827:11346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59578.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          109 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagagcatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggccctg tcccaggtgc ttctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcaatagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaaccccg ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001097             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:26446:7029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001097
VERSION     KCXD01001097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:26446:7029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59579.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          105 a          145 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccat agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgtatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga catctgacga cacggccgtc tattactgtg cgattggccc tagcggcagt
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001098             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:10787:13089
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001098
VERSION     KCXD01001098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:10787:13089"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..484
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59580.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>488
                     /gene="IGHG"
BASE COUNT          117 a          142 c          131 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgac tacaccttcg ccgaattacc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gttttgctag tatatatggt gaaataatac
      301 atacagagag attccagggc agagtcacca tgacagcgga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta cccattttac tacttcgata tctggggccc tggcaccccg atcaccatct
      481 cctccgcc
//
LOCUS       KCXD01001099             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23604:9363
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001099
VERSION     KCXD01001099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23604:9363"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..283
     V_segment       10..208
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <202..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59581.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       223..234
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       235..283
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           67 a           75 c           84 g           59 t
ORIGIN      
        1 acatggggaa ccttcaccga attatccatg cactgggtgc gacaggcccc tggaaaaggg
       61 cttgagtggg tgggaagtgt tgatcctgaa tatggtgaaa tgatgttcca gggcagagtc
      121 accatgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag cctgagatct
      181 gaggacacgg ccgtctatta ctgtgcgatt ggccctagtg gcagctggaa cgactggtcc
      241 ttcgacattt ggggacctgg caccccaatc accgtctcct cagcc
//
LOCUS       KCXD01001100             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22749:12373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001100
VERSION     KCXD01001100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22749:12373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59582.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT           99 a          125 c          161 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggtt tcagcttcag tttctactat
      241 atgacctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattgacact
      301 ggtggggata gcacctacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga agacactgta tcttcagatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagtagt gggtggtgcc gccggatact tcgatttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001101             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:4422:9142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001101
VERSION     KCXD01001101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:4422:9142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59583.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          150 c          141 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgagca agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtcaatgg tgaactcata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggact tgagcagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01001102             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20557:6709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001102
VERSION     KCXD01001102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20557:6709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59584.1"
                     /translation="CARKLPGLQLTGLDSW"
     D_segment       415..421
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          139 c          134 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacggc catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag aagggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtttctgg
      181 tgactccatc aagagtggct actactggag ctgggtccgc caacccccag ggaaggggct
      241 acagtggatt gggtttatcg gtggtagtag tggtagcacc tacgtcaact cctccctcaa
      301 gagtcgagcc accctttcaa aagacacgtc caggaaccag ttctccctga aactgaactc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga aaacttccag gtctgcaact
      421 aaccggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001103             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6003:6350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001103
VERSION     KCXD01001103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6003:6350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59585.1"
                     /translation="CARDRRVESLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          126 c          156 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag ttactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaccagt
      301 ggtgggggta acacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aactccaaga ccacactgta tcttcacatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg caagagatcg acgtgtagag tcgttatcct ggttcgatgt ttggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001104             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15486:4766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001104
VERSION     KCXD01001104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15486:4766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59586.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          124 c          156 g          119 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagccgg
      181 gggggtccct gagactctcc tgcgcagtct ctggattcag tttcagtcac tacttcatga
      241 gctgggtccg ccagactcca gggaagggac tggagtggat ctcagtgatt aacagtggtg
      301 gagataccac acactatgca gactccgtga agggcagatt caccatgtcc agagagaacg
      361 ccaggaacac actgtctctt caaatggacg gcctgagacc tgaggactcg gctgtctatt
      421 actgtgcgag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001105             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:15399:18234
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001105
VERSION     KCXD01001105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:15399:18234"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59587.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       235..239
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           71 a           72 c           79 g           67 t
ORIGIN      
        1 acatggggga ttcaccttca gttcctttgg catgcactgg gtccgccagg caccggggaa
       61 ggggctggag tgggtggcag ttttatcgtc tgatggaact aacaaatact acgcagactc
      121 tttgaaagac cgattcacca tatccagaga caactccaag aacatactat atcttcaact
      181 gaacaacctg aaattggagg acacggccgt gtattactgt gcgagagatg tgtatggctc
      241 ggggcttgac tactggggcc agggagtcct gctcaccgtc tcctcagcc
//
LOCUS       KCXD01001106             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15754:4277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001106
VERSION     KCXD01001106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15754:4277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..432
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59588.1"
                     /translation="CARGIDNYHYTDTDFDYW"
     D_segment       444..451
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          113 a          117 c          151 g          130 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tgggattccc aggtgttttc attcagagat
       61 caggactgaa cacacaggac tcaccatgga gtttatgctg agctgggttt tccttgttgc
      121 tatgttaaaa ggtgtccagt gtgtggagca gctggtggaa tctgggggag gcttggtaca
      181 gcctggggcg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttga
      241 catgcactgg gttcgccagg ctccagggaa gggtctggac tgggtatcag gtattaacat
      301 tggcggtgac acatactacc cagactctgt gaagggtcga ttcactatgt ccagagacaa
      361 tgccaagaac tccgtgtatc ttcaaatgaa cagcctgaga gttgaggaca ctgctgtgta
      421 tttttgtgca agggggatag ataactacca ctatactgat acggactttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001107             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11112:11663
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001107
VERSION     KCXD01001107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11112:11663"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59589.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          138 c          154 g           99 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctggaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 ggggttcggt agcagtgtct ggtccaatct cgtttatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01001108             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:17664:14062
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001108
VERSION     KCXD01001108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:17664:14062"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59590.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       406..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           91 a          142 c          136 g          101 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccaaat gcgtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccttcag caacttctac tggaactgga tccgccagac cccagggaag gggctggagt
      241 ggattgggtg tatcagtggt gatagtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtccacat ttcgacagac acgtccaaga aacagttctc cctgaagatg agctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagaccc ccggtggcag ctggaactcc
      421 tcttctttga ctattggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001109             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:26378:10595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001109
VERSION     KCXD01001109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:26378:10595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59591.1"
                     /translation="CARGYRSDWPNFDYW"
     D_segment       397..404
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           91 a          138 c          136 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcctcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacgtgcac tgtctctggc
      181 ggctccatca gcggttactt ctggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg gtatcggtgg tgctactgtg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtccaag agccagttct ccctgacact gacgtctgtg
      361 atcgccgcgg acacggccgt atattactgt gcgaggggat ataggagcga ctggcctaat
      421 tttgactact ggggccacgg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001110             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10742:6467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001110
VERSION     KCXD01001110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10742:6467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59592.1"
                     /translation="CARVTGIDGTTVEYFDFW"
     D_segment       438..453
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..507
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          118 c          157 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttctcctt gtcgctattt
      121 taagaggtgt ccaatgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagagtctcc tgtgcggcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcatctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatgtt cagatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agtaaccggt atagatggaa ctaccgttga atacttcgat ttctggggcc
      481 agggcgccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001111             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8319:12629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001111
VERSION     KCXD01001111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8319:12629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59593.1"
                     /translation="CTGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          125 c          155 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctggact gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agatggtgga gtctgggggc ggcttggcaa
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactact
      241 ggatgaactg ggtccgccag actccaggaa aggggctgga gtgggtctca gctattaatt
      301 atgatggggg tagcgcatac tacgcagact ccgtgaaggg ccgattcacc atttccagag
      361 acaactcaaa gagtacgctc tccctgcaaa tgagcagcct gagagcggag gacacggccg
      421 tatattactg tacgggcggg gcatacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001112             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6899:14227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001112
VERSION     KCXD01001112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6899:14227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59594.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          129 c          145 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga tgcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagcgtc accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaaataatt
      301 cacggagagg ggttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatcagag gacacggccg tttattattg tgcgagtggg
      421 tttagtatct ggttatttta cgacgttctg gattcgtggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001113             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:28932:10213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001113
VERSION     KCXD01001113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:28932:10213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59595.1"
                     /translation="CARDEGEISGFRFGYW"
     D_segment       451..457
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          114 a          108 c          161 g          125 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgaaac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtt
      301 tgatggaagt aagaaatact acggagactc tgtgaaggac cgattcatca tctctagaga
      361 caattccaag aacatgttat atcttcaaat gaacaacctg agattggagg acacggccat
      421 gtattactgt gcgagggatg agggggagat tagtgggttc cgatttggct actggggcca
      481 gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001114             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:15475:19515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001114
VERSION     KCXD01001114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:15475:19515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..378
     V_segment       8..289
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59596.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       299..322
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       345..378
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           85 a          100 c          116 g           79 t
ORIGIN      
        1 acatgggggt gcagtccggg gctgaggtga agaggcctgg ggcctcagtg aagctctcct
       61 gcaaggctcc tggatacatc ttcagcatat ctgccatcag ttgggtgcga caggcccctg
      121 gacaagggct tgagtggatg ggagggatca tccctcttgt tggtgtaaca acctacgcac
      181 agaacttcca ggacagagtc acgattaccg cggacacgtc cacaagcaca gcctacatgg
      241 agctgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgagt ggcggcttcg
      301 aggatgataa cggtcactat tatacgacac taacatttca cgagtggggc cagggagtcc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001115             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13753:6458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001115
VERSION     KCXD01001115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13753:6458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..494
     V_segment       134..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <416..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59597.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       430..437
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..494
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          128 c          145 g          116 t
ORIGIN      
        1 acatggggga ggagcccagc actggaagtc cacagtgttc cattcggtga tcagcactga
       61 acacagagga ctcaccatgg agtctgggct gagctggctt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc aggtggagga gtctgggggc ggcttggcaa agcctggggg
      181 atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg ctatgcattg
      241 ggtccgccag gctccaggga aggggctgaa atgggtctca tctattagta gtggtggtct
      301 cacatactac gcagactccg tgaagggccg atttgccatc tccagagaca actcaaagaa
      361 cacgctctcc ctgcaaatga acagcctgag cgctgaggac acggccgtat attactgtgc
      421 gaaaggaggt agcagctctt tctattggta cttcgatatc tggggccctg gcaccccagt
      481 gaccatctcc tcagcc
//
LOCUS       KCXD01001116             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19466:17734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001116
VERSION     KCXD01001116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19466:17734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59598.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          115 a          113 c          155 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaac taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tctattattg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01001117             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8232:16922
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001117
VERSION     KCXD01001117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8232:16922"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59599.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       399..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           99 a          136 c          138 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagt atctgtggtt
       61 cctcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
      121 gggcccagga ctgatgaagc cttcagagac cctgtccctc agctgcgctg tctctggtgg
      181 ctccataagt ggtaactggt ggagctggat ccgccagccc ccagggaagg gactggactg
      241 gattggacgt atctctggta ctagtgggga caccaattac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga actctgtgac
      361 cgccgcggac gcggccgtgt attattgtgc aagagcggat tacgaggatg attacggtta
      421 tcatttagga tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01001118             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11174:4599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001118
VERSION     KCXD01001118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11174:4599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59600.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           94 a          131 c          129 g          105 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agtcttcgga gaccctgtcc ctcacctgcg gtgtctctgg tgactccatc
      181 agcaatagct actggaactg gatccgccag cccccaggga agggactgga gtggattggg
      241 tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt gaccgccgcg
      361 gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta ccactttgac
      421 tgctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001119             528 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20167:15700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001119
VERSION     KCXD01001119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20167:15700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    154..526
                     /note="immunoglobulin heavy chain variable region"
     V_region        154..526
     V_segment       154..446
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <445..>495
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59601.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       457..466
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       484..526
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        527..>528
                     /gene="IGHG"
BASE COUNT          124 a          121 c          155 g          128 t
ORIGIN      
        1 acatggggga ccctgcagct ctgggagagg agacccagcc ttgggatttc cagctgtctc
       61 cacttggtga tcagcactga acacaggaga ctcgccatgg agtttgtact gagctgggtt
      121 ttccttgttg ctatattaaa aggtgtccag tgtgaggtgc agctggtgga gtctggggga
      181 ggcttggtcc agcctggcgg gtccctgaga ctctcctgtg cagcctctgg attcaccttc
      241 aatgagtatg ccatgagctg ggtccgccag gcttctggga aaggactgga gtggattggc
      301 tatattagaa gcaaatataa cgattacgcg acagaatatg ccgcatcggt gaaaggcaga
      361 ttcaccatct ccagagatga ttcaaagaac acactatatc tgcagatgag cagcctgaaa
      421 accgaggaga cggccgtgta ttactgcacc cgtctctata gtgggaacta tagaattatg
      481 atgtttgact actggggcca gggagtcctg gtcagtgtct cctcagcc
//
LOCUS       KCXD01001120             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13965:10182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001120
VERSION     KCXD01001120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13965:10182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59602.1"
                     /translation="CAKDAFGSGCDFW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          118 c          153 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag tctctggatt caccttcagt acctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atctcgaatg
      301 atggaactaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa gttggaggac acggccgtgt
      421 tttactgtgc gaaagacgcc tttggcagcg gctgtgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001121             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21071:3959
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001121
VERSION     KCXD01001121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21071:3959"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59603.1"
                     /translation="CARTECSRGVCYFDYW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          111 a          119 c          156 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccac tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
      241 gcatgaattg ggtccgccag gctccaggga aggggctgga gtgggtggca gttctatcgt
      301 ttgatggaac taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc aatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tctattattg tgcgcgaacg gagtgtagtc gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001122             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12771:14286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001122
VERSION     KCXD01001122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12771:14286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59604.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          134 c          138 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatctatgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtgga cacgtccgag aaccagtgct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001123             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17488:4286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001123
VERSION     KCXD01001123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17488:4286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59605.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          140 c          149 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg agacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg ggaaataata
      301 cacgcagata acttccaggg cagagtcacc atgaccgagg acacgtctat agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tatattactg tgcgagcggg
      421 acatttggga ccagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca gcgtctcctc agcc
//
LOCUS       KCXD01001124             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12537:10078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001124
VERSION     KCXD01001124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12537:10078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59606.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       435..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          142 c          142 g           98 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccaac tggtgcagtc tggggctgaa atgaagaagc ctggggcctc agttagggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gtcgatcctg cacaaggtga aataatacac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagccttc
      361 atggagttga gcagcctgag atctgaggac acggccgtgt atttctgtgc gaaagggggg
      421 ttcggaacca gcgtctggtc caacctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001125             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18447:19508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001125
VERSION     KCXD01001125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18447:19508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..463
     V_segment       85..377
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59607.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       383..390
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..463
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           96 a          123 c          147 g           99 t
ORIGIN      
        1 acatgggggg gaacacagct catcaccatg gacttgacct ggaggctcct ctttgtggtg
       61 gcagcagcta caggtgccca gtcccaggtc cagctggtgc agtccggggc tgaggtgagg
      121 aagcctgggg cctcagtgaa gctctcctgc aaggcttctg gatacacgtt cagcatctat
      181 gccatcagtt gggtgcgaca ggcccctgga caagggcttg agtggatggg agggatcatc
      241 cctcttgttg atgtaacaaa ctacgcacag aagttccagg gcagagtcac gattaccgcg
      301 gacacgtcca caagcacagc ctacatggag ctgagcagcc tgagatctga ggacacggcc
      361 gtgtatttct gtgcgagggg agattgtact gatactgact gctcttccgc ggggggcgcc
      421 tttgatttct ggggccaagg actcagggtc accgtctctt cagcc
//
LOCUS       KCXD01001126             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16964:10228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001126
VERSION     KCXD01001126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16964:10228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59608.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       430..434
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          106 a          121 c          157 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aatataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcaact tcaattacta ctacatgaac
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattaa cagtggtggg
      301 gatagcacat actatgcgga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaacacac tgtatcttca aatggacagc ctgagagctg aggacacggc tgtctattac
      421 tgtgcgagag tggtgggtgg tgccgcagga tacttcgact tctggggcca gggcgccctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001127             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22621:9260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001127
VERSION     KCXD01001127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22621:9260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59609.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          119 a          141 c          132 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaaccct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctactt
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga cctcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01001128             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13269:9347
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001128
VERSION     KCXD01001128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13269:9347"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59610.1"
                     /translation="CAVGPSGTWNHWSFDVW"
     D_segment       409..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          148 c          131 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      301 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      361 cagcctgaca tctgacgaca cgtccgtcta ttactgtgcg gttggcccta gcggcacttg
      421 gaaccactgg tccttcgatg tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01001129             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:24448:7947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001129
VERSION     KCXD01001129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:24448:7947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59611.1"
                     /translation="CVTDARGSGLDSW"
     D_segment       436..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          114 c          157 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggactcac cttcagtagc tatggcctgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtcaca tcgtctgatg
      301 ggagtaagaa atactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 tcaagaacat gctttatctt caaatgaaca gcctgaaatt ggaagacacg gccgtgtatt
      421 actgtgtgac agatgcgagg ggttccggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001130             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14474:2715
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001130
VERSION     KCXD01001130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14474:2715"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59612.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       435..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          110 a          117 c          143 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcggc ctggggggtc
      181 cctgagactc tcctgttcag cctctggatt caccttcagt aattttggca tccactgggt
      241 ccgccaggct ccagggaagg gcctggagtg ggtggcagtt acatcgtctg atgaaagtaa
      301 gaaatactat gcagactctg tgaaggaccg attcaccctc tccagagaca attccaagaa
      361 tatactatat cttcaaatga acaacctgaa gttggaggac acggccgtct attactgtgc
      421 gagagacgca tatggcagcg gctgtgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001131             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20836:7479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001131
VERSION     KCXD01001131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20836:7479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59613.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          132 c          138 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggagat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atatttggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaggctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001132             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5133:17776
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001132
VERSION     KCXD01001132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5133:17776"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..398
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59614.1"
                     /translation="CARWGDSQSIYYFDFW"
     D_segment       399..403
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           92 a          137 c          133 g          108 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacatgcgct gtctctggtg
      181 actctattac cagtagtagc tggtggaact ggatccgcca gcccccaggg aaagggctgg
      241 aatggattgg ttatatcagt ggtactagtg ggagcaccga ctatcacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt taccctgacg ttgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagatg gggcgactcc cagtccattt
      421 actactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001133             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20508:6519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001133
VERSION     KCXD01001133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20508:6519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59615.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          145 c          140 g           96 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgagttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc ctgaccgagg acacgtctac atacacagcc
      361 tacatggagc tgagcagcct gtcatctgag gacacggccg tgtatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001134             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21815:16034
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001134
VERSION     KCXD01001134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21815:16034"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..470
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59616.1"
                     /translation="CARHRPYYFSASYWANWFDVW"
     D_segment       396..416
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>474
                     /gene="IGHG"
BASE COUNT           92 a          139 c          134 g          109 t
ORIGIN      
        1 acatggggga gagtcacaga catcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tctcaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcgattact actgcagttg gatccgccag gccccaggga agggactgga gtggattggc
      241 tatatctctg gtgatagcgg gagcaccaac ttcaagccgt ccctcaagag tcgagtcacc
      301 atttcaaaag acacgtccaa gaaccagttc tccctgaccc tgagttctgt gaccgccgcg
      361 gacacggccg tctattactg tgcgagacat cgaccgtatt actttagtgc tagttactgg
      421 gctaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01001135             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14178:7627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001135
VERSION     KCXD01001135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14178:7627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59617.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          116 c          149 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagagatgt ccactgtgag gtgcacctgg tggaatctgg aggaggttcg gctcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcattc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001136             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24609:15100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001136
VERSION     KCXD01001136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24609:15100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59618.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       422..431
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          120 a          140 c          127 g          101 t
ORIGIN      
        1 acatggggga acacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga accaccttca ccgaattatc cctgcactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gttttaatcc tatttatggt gaaattttac
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagaagcctg atatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta tccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01001137             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15405:10597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001137
VERSION     KCXD01001137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15405:10597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59619.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          124 c          160 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggag agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01001138             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12024:9056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001138
VERSION     KCXD01001138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12024:9056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59620.1"
                     /translation="CATHGGNRGIWNSLYNGFDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          141 c          144 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggttc agttggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aagtttccgg atacaccttc accgatttat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctggacatgg tgaaataatg
      301 cacgcagaca acttccaggg cagagtcgcc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgacccac
      421 ggagggaata gaggcatctg gaactcccta tataacggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001139             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:2622:10314
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001139
VERSION     KCXD01001139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:2622:10314"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59621.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          143 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccaa ctgatacagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaga ttccagggca gagtcacctt gaccgaggac acgtctacag gaacgaccta
      361 catggagctg atcagtctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcacc tggctatatt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001140             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:26825:14352
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001140
VERSION     KCXD01001140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:26825:14352"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59622.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       445..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          123 c          147 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttcctttgg
      241 catgcactgg gtccgccagg caccggggaa ggggctggag tgggtggcag ttttatcgtc
      301 tgatggaact aacaaatact acgcagactc tttgaaagac cgattcacca tatccagaga
      361 caactccaag aacatactat atcttcaact gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctc ggggcttgac tactggggcc agggagtcct
      481 gctcaccgtc tcctcagcc
//
LOCUS       KCXD01001141             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19811:4371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001141
VERSION     KCXD01001141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19811:4371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59623.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       411..417
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          149 c          132 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtctccgg aaacaccttc accgaattgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ccgcatatgg tgaaatgacg
      301 ttccagggca gagtcatcat gaccgaggac acgtctacag acacagccta catggaactg
      361 accagcctga catctgacga cacggccgtc tattactgtg cggttggccc tagtggcact
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc cagtcaccat ctcctcagcc
//
LOCUS       KCXD01001142             277 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17809:12067
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001142
VERSION     KCXD01001142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 277)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 277)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17809:12067"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..275
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..275
     V_segment       8..178
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <170..>244
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59624.1"
                     /translation="CARDAGYGDTISLVDINMFPHFDYW"
     D_segment       196..219
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       231..275
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        276..>277
                     /gene="IGHG"
BASE COUNT           65 a           68 c           74 g           70 t
ORIGIN      
        1 acatgggggg aagggactgg agtggattgg ggagatcaat ggtaatagtg gtagttttta
       61 ctacaaccct tccctcatca gtcgagtctc catttcaaaa gacgcgtcca agaatcactt
      121 ctccctgaag ctaagctctg tgaccgccgc ggacacggcc gtatattatt gtgcgagaga
      181 tgccgggtat ggggatacga tatcactagt cgatattaat atgttccccc actttgacta
      241 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001143             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22713:13384
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001143
VERSION     KCXD01001143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22713:13384"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59625.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           98 a          138 c          135 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgc
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ttggagctgg atccgccagc ccccagggaa gggactggaa
      241 tggattgggt atattagtgc cagtactggg agcaccgact acaacccctc cttcaagagt
      301 cgagccgcca tttcaacaga cacgtccaag aaccagttct ccctgagact gacgtctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagaga aatactatag tggtagttac
      421 aaacacaact ggttcgatgt ctggggtccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001144             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12363:4100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001144
VERSION     KCXD01001144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12363:4100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59626.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          112 c          153 g          117 t
ORIGIN      
        1 acatggggag gtctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcacacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaattct acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgagagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001145             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7737:3318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001145
VERSION     KCXD01001145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7737:3318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59627.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       443..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          118 c          152 g          114 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 tttagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggtccagcct
      181 gggggctccc tgagactctc ctgtgcagcc tctggattca ccttcaatac ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcacatgat
      301 gaaactaaga gatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgagc aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagacgcatt tggcagcggc tgtgactact ggggccgggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001146             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17206:14768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001146
VERSION     KCXD01001146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17206:14768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59628.1"
                     /translation="CTRGSYSGSYYFNRFDVW"
     D_segment       406..425
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           94 a          138 c          136 g          110 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg
      181 tggctctatc agcagtagta cctggtggaa ctggatccgc cagcccccag ggaaaggcct
      241 ggagtggatt gggtatataa gtggtgatag tggtagcacc tactacaacc cctccctcaa
      301 gagtcgaatc accatttcaa cagacacgtc cacgagccag ttctccctga ggctgagctc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtacgaga ggttcctata gtggtagtta
      421 ttacttcaac cggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001147             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18781:18196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001147
VERSION     KCXD01001147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18781:18196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59629.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       418..424
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          138 c          141 g          100 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagtcccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtacag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggag gtgttgatac tgtatctgat ggaatgatat
      301 acgcagaaaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gcgagaggtg
      421 tgacagcaga cgtcttcggt ttcctcgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001148             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:25307:19430
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001148
VERSION     KCXD01001148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:25307:19430"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59630.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       443..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          114 c          150 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgcgatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 gaggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttt ctatggcttc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ttcgaatgat
      301 gaaaataaca aatactacgc agactctgtg aaggaccgat tcaccatttc tagagacaat
      361 tccatgaaca tgctatttct tcaaatgaac aacctgaact tggacgacac ggccgtctat
      421 tactgtgtga gagatgattt aggcagcggc ttagggtcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001149             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13124:19092
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001149
VERSION     KCXD01001149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13124:19092"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    187..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        187..363
     V_segment       187..284
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59631.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       294..305
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       322..363
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           65 a          116 c          106 g           78 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggagcag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgcca ggtctccatc tcagccgaca agtccatcag caccgcctac ctgcagtgga
      241 gcagcctgaa ggcctcggac accgccacgt attactgtgc gaaagggggg tggtggggtg
      301 attatccacc ctcagactgg ctcgatgtct ggggcccggg agtcctggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01001150             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12603:6731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001150
VERSION     KCXD01001150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12603:6731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..477
     V_segment       103..410
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59632.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       417..426
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>483
                     /gene="IGHG"
BASE COUNT           83 a          142 c          142 g          116 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggag
      241 tggattgggt gtatctttgg tggtggtatc tttggtggtg gaagtaacac cttctacagc
      301 ccttccctca agagtcgagt caccctgtca gtggacgcgt ccaagaccca gctctccctg
      361 aagctgacgt ctgtgaccgc cgcggacacg gccgtgtatt tctgtgcgag cgctgatagt
      421 ggttatcctc cctacttctt tgacatctgg ggccagggag tcctggtcac cgtctcccca
      481 gcc
//
LOCUS       KCXD01001151             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20649:8350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001151
VERSION     KCXD01001151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20649:8350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59633.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       436..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          104 a          124 c          160 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattgacagt
      301 ggtggggata gcacatacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaattg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001152             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:12438:10499
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001152
VERSION     KCXD01001152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:12438:10499"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59634.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          142 c          136 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atataccttc accgaactgt ccattcattg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacgcagaaa aattccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggacc tgatcagtct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca cctggctata ttggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001153             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22000:16794
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001153
VERSION     KCXD01001153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22000:16794"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59635.1"
                     /translation="CVRYEDESINYHFDSW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          137 c          129 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagtaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001154             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20732:6316
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001154
VERSION     KCXD01001154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20732:6316"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59636.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          140 c          149 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagagc ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg aatagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001155             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24556:15840
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001155
VERSION     KCXD01001155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24556:15840"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59637.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       398..413
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           88 a          143 c          133 g          100 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctctccct cacctgcgct gtctctggtg
      181 actccatcag cagtacctac tggagctgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt ggtggtggga acaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaagagac acgtccagga accagttctc cctgcagctg aattatgtaa
      361 ccgccgcgga cacggccgtg tattactgtg ccagaactag cggtggctgg tccccctact
      421 ttgactattg gggccgggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001156             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20113:5303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001156
VERSION     KCXD01001156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20113:5303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59638.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       443..450
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          118 c          148 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agcaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaag taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaaatggag gacacggccg
      421 tttattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01001157             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17220:5269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001157
VERSION     KCXD01001157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17220:5269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59639.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          114 c          162 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtcactgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctttaggga agggactgga gtgggtggca ctgatatctt
      301 atgatggaag taagaaatac tacgcagaat ccgtgaagga ccgattcacc atctccagag
      361 acaattccac gaacatgctg tatcttcaaa tgaacaacct gaaactggat gacacggccg
      421 tgtattactg tgcgcgagtt ggagagggta gtggtggtgc ggaggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001158             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24660:15294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001158
VERSION     KCXD01001158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24660:15294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59640.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          119 c          145 g          134 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga atctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agttcctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtttcc ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 atgccaagaa ctccttgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtac aagggggata gataactacc actttagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001159             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22350:13185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001159
VERSION     KCXD01001159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22350:13185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59641.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       456..465
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          114 a          119 c          159 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagttgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc acttatctcg
      301 tttgatggaa ctaagcaatt ctacgcagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct atatctccaa atgaacaacc tgaaattggg ggacacggcc
      421 gtacattact gtgcgagagt tagtgggcat acggagggta cagttgaata ctttgactac
      481 tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001160             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6980:15514
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001160
VERSION     KCXD01001160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6980:15514"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..511
     V_segment       136..425
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59642.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       463..469
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          111 a          122 c          160 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggta tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcacctggtg cagtctgggg gcggcttgac aaagccgggg
      181 gggtccctga gactctcctg tgcagcctcc ggattcacct tcagtgacta ctatatggac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtct cacgaatcgg tcatgatggt
      301 ggtagcacat ggtacgcaga ctccgtgaag ggcagattta ccatttccag agagaatgcc
      361 aagaacacac tgtttcttca aatggacagc ctgagaagtg aggacacagc cgtatattac
      421 tgtgccagag agcggtttgg gggaattggg gtaattatct tcaactggat cgatgtctgg
      481 ggcccgggag tcctggtcac cgtcccctca gcc
//
LOCUS       KCXD01001161             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12777:20255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001161
VERSION     KCXD01001161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12777:20255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59643.1"
                     /translation="CVKGETAAAYYGLDSW"
     D_segment       435..440
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          121 c          158 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtact tatgctatga
      241 attgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctgtt agtagtagtg
      301 gaagtacata ctacgcagac tccgtgaagg gccggtgcac catctccaga gacaactcaa
      361 agaacatgct ctccctgcaa atgaacagcc tgagcgctga ggacacggcc gtgtattact
      421 gtgtgaaagg agaaacagct gcagcatact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001162             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19083:16666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001162
VERSION     KCXD01001162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19083:16666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..487
     V_segment       127..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59644.1"
                     /translation="CATADSGYPFYYFDFW"
     D_segment       422..429
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          117 a          141 c          130 g          101 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggc gcagtctggg gctgacgtga agaagcctgg ggcctcagtg
      181 aaggtctcct gtaaggtttc cggatacacc ttcaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaaggact tgagtggatg ggaggttttg ctcctatata tggtgaaata
      301 atacacgcaa agttccaggg cagagtcagt ttgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctattattg tgcgacagct
      421 gatagcggtt acccatttta ctacttcgat ttctggggcc ctggtacccc aatcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01001163             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20133:10748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001163
VERSION     KCXD01001163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20133:10748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..471
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59645.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       414..420
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           98 a          139 c          132 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagacttcgg agaccctgtc cctcacctgc gctgtttctg
      181 gtgactccat caacagtggc tactactgga gctggatccg ccaaccccca gggaaggggc
      241 tggagtggat tgggtatgtc ggtggtagta gtggtaccac ctactacaac tcctccctca
      301 agagtcgagt caccctttca aaagacacgt ccaggaacca gttctccctg aaactgagcg
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag aaaacttcca ggtctacaac
      421 taaccggttt cgattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001164             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11665:10165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001164
VERSION     KCXD01001164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11665:10165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59646.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          119 c          150 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcccag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagtg caactggtgg agtctggagg aggcttggtt
      181 cggcctgggg ggtccctgag actctcctgt tcagcctctg gattcacctt cagtaatttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaagaaata ctatgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaatatgct atatcttcaa atgaacaacc tgaagttgga ggacacggcc
      421 gtctattact gtgcgagaga cgcatatggc agcggctgtg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001165             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14839:12851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001165
VERSION     KCXD01001165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14839:12851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..480
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59647.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       410..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>484
                     /gene="IGHG"
BASE COUNT          116 a          140 c          130 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggctaca gcttcgccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggttt tgctagtata tatggtcaaa taatacatac
      301 agagagattc cagggcagag tcaccatgac agcggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtgtat tactgtgcgg cagctgatag
      421 tggttaccca ttttactact tcgatatctg gggccctggc accccaatca ccatctcctc
      481 cgcc
//
LOCUS       KCXD01001166             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:4910:9199
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001166
VERSION     KCXD01001166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:4910:9199"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    154..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        154..517
     V_segment       154..445
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <439..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59648.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       455..472
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          104 a          157 c          136 g          122 t
ORIGIN      
        1 acatgggggg agtctccctc accacccagc tggggatctc agtgcttcat tttctgtcct
       61 tcatttctca gtgcttcatt tctgtcctcc accacgatgg ggtcaactgc catcctcgcc
      121 ctcctcctgg ctgttctcca aggagtctgt gccgaggtgc agctggtaca gtctggagca
      181 gaggtgaaaa ggcccgggga atctctgagg atctcctgta agacttctgg atacagcttt
      241 accagttact ggatcagttg ggtgcgccag atgcccggga aaggcctgga gtggatggga
      301 atgatctatc ctagtgattc tgatcccaga tacagcccgt ccttccaagg ccaggtcacc
      361 atctcagccg acaagtccat cagcaccgcc tacctgcagt ggaacagcct gaaggcctcg
      421 gacaccgcca cgtattactg tgcgagagct ggacgataca cctacagtta cccctttgac
      481 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001167             378 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24228:15486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001167
VERSION     KCXD01001167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 378)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 378)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24228:15486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    22..376
                     /note="immunoglobulin heavy chain variable region"
     V_region        22..376
     V_segment       22..315
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <307..>345
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59649.1"
                     /translation="CARDDSGTGFDYW"
     D_segment       320..328
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       334..376
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        377..>378
                     /gene="IGHG"
BASE COUNT           86 a           83 c          120 g           89 t
ORIGIN      
        1 acatggggag gtgtccagtg tgaagtgcaa ctggtggagt ctggaggagg cttggttcag
       61 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taactatggc
      121 atgcactggg tccgcctggc tccagggaag gggctggagt gggtggcagt tatgtcgaat
      181 gatggaatta ataagtacta cgcagactct gtgaaggacc gatacaccat ctccagagac
      241 aattcgagga acatgctgta tcttcaaatg aacaacctga aattggagga cacggccgtg
      301 tattattgtg cgagagatga tagtgggacc ggttttgact actggggcca gggagtcctg
      361 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001168             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18860:18610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001168
VERSION     KCXD01001168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18860:18610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59650.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       424..432
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          126 c          144 g          105 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagatgcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca gcgtcaccga attatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgta aaaggtgaaa taattcacgg
      301 agaggggttc caggacagag tcaccatgac cgaggacccg tctatagaca cagcctacat
      361 ggagttgagc aacctgagat cagaggacac ggccgtttat tattgtgcga gtgggtttag
      421 tatctggtta ttttacgacg ttctggattc gtggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001169             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18687:6846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001169
VERSION     KCXD01001169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18687:6846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59651.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          122 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtcagg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tggtgggact accacaaatt atgcagactc cgtgagggac agcttcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagccgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat tattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001170             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9238:9366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001170
VERSION     KCXD01001170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9238:9366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59652.1"
                     /translation="CAAGHSGSWNYWYFDFW"
     D_segment       425..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          139 c          142 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctgcaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggggg tgttgatcct gcatttggtg aaatgataca
      301 cgtagagagg ttccagggca gagtcaccct gaccgaggac acgtctacag atacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tttttctgtg cagccggaca
      421 tagtggcagc tggaactact ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001171             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:5627:6958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001171
VERSION     KCXD01001171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:5627:6958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..474
     V_segment       121..414
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59653.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       418..433
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>477
                     /gene="IGHG"
BASE COUNT          101 a          147 c          123 g          106 t
ORIGIN      
        1 acatgggggt ctccctcacc gcacagctgg gatctcagtg cttcatttct ttcctccacc
       61 acgatggggt caactgccat cctcgccctc ctcctggctg ttctccaagg agtctgtgcc
      121 gaggtgcagc tggtgcagtc tggaacagag gtgaaaaggc ccggggagtc tctgaggatc
      181 tcctgtcaga cctctggata caactttccc agcagctgga tcacctgggt gcgccagatg
      241 cccgggaaag gcctggagtg gatggggacc atctatcctg ctgattctaa tgccaaatac
      301 aacccgtcct tccaaggcca cgtcactatc tcagtcgaca agtccatcag caccacctac
      361 ttgcagtgga gcaacctgaa ggcctcggac accgccacgt attactgtgc caaaacctac
      421 tatagtggta gtttggaata ctggggccag ggagtcctgg tcaccgtctc ctcaacc
//
LOCUS       KCXD01001172             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17776:3758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001172
VERSION     KCXD01001172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17776:3758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59654.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          122 c          157 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tgttaatagt
      301 ggtggggaaa gcacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactata tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001173             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19970:8979
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001173
VERSION     KCXD01001173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19970:8979"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..497
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59655.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       430..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          102 a          125 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagtacata ctacgcagac tccgtgaggg gccgattcac catctccaga gacaactcag
      361 agagcacgct ctccctgcaa atgaacagcc tgagcctgag gacacggccg tgtattactg
      421 tgccaaaggg gatacagcta cagtttatta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001174             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6570:16245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001174
VERSION     KCXD01001174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6570:16245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59656.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          141 c          136 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccaggaaagg ggctggagtg
      241 gattgggttt ttcggtggtt atggtgggag cacctactac aacccctccc tccagagtcg
      301 agtcaccatt tcagccgaca cgtccaaaca ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct actattgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001175             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:2970:11325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001175
VERSION     KCXD01001175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:2970:11325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59657.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       402..409
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           85 a          137 c          131 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca ggaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcgattactt ctggaactgg atccgccagt ccccagggag ggggctggag
      241 tggattggat atatctatgg tgctactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacct tttcagcaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt ttattattgt gcgagatatc agggtgattc cttgtactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001176             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21653:4115
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001176
VERSION     KCXD01001176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21653:4115"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59658.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       439..445
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          115 a          116 c          159 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttcg gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatatcgtt
      301 tgatggaact aagcaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggggg acacggccgt
      421 gcattactgt gcgagagtta gtgggcatac agagggaaca gttgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001177             429 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8234:10738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001177
VERSION     KCXD01001177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 429)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8234:10738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..427
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..427
     V_segment       76..368
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>396
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59659.1"
                     /translation="CASLLNPSSDSW"
     D_segment       374..379
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       387..427
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        428..>429
                     /gene="IGHG"
BASE COUNT           78 a          126 c          129 g           96 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggtagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagtcttcg
      121 gagaccctgt ccctcacctg cgctgtttct ggtggctcca tcaggggtta ctggtggggc
      181 tggatccggc agtccccagg gaagggtctg gagtggattg gctatatcgg tggcagtagt
      241 gggagcacct actacaaccc ctccctcaag agtcgagtca ccatttcaac agacacgtcc
      301 aagaaccaga tttccctgaa gctgacctct gtgaccgccg cggacacggc cgtgtattcc
      361 tgtgcgagtc ttctaaaccc ttcgagtgac tcctggggcc agggagtcct ggtcaccgtc
      421 tcgtcagcc
//
LOCUS       KCXD01001178             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15154:10802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001178
VERSION     KCXD01001178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15154:10802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59660.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          119 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gcctgggggg accctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagttgg gtccgtcagg ctccagggaa ggggctggag tggatctcaa gtattgacaa
      301 tggtgggact accgcaattt atgcagactc cgtgaggggc agattcagca tctccagaga
      361 gaacgccaag aacacactgg atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattattgt gcgagagcac gcggggtgat cattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001179             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:27333:16196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001179
VERSION     KCXD01001179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:27333:16196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59661.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       439..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          124 c          149 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agttgggctg agctgggttt tccttgttgc
      121 cattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tcccggagac tctcctgtgc agcctccgga ttcaccttca gtacctatgc
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgca
      301 tgatggaact aagaaattct acacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatacaat atcttcacat gaacaacctg aaattggagg acacggccat
      421 atactactgt gcggcctcct acttggggta cggatttgag tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001180             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18881:8698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001180
VERSION     KCXD01001180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18881:8698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..481
     V_segment       103..402
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59662.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       414..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          100 a          135 c          137 g          111 t
ORIGIN      
        1 acatggggat gctccctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcga tgtctctggt
      181 tactccatca gcagtggtta ctactactgg ggctggatcc gtcagccccc agggaagggt
      241 ctggagtgga ttgggtatat aggtggtagt actgggacct cctactacaa ccccgccctc
      301 aagagtcgag ttaccatttc aaaagacacg tccaagaacc agttttccct gaaggtgagc
      361 tctgtgaccg ccgcggacac ggccgtttat cactgtgcga gacatggagg tttctatagt
      421 gcgactgaca agtcaacatt tgacaactgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01001181             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9428:18837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001181
VERSION     KCXD01001181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9428:18837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59663.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       436..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          107 a          117 c          152 g          121 t
ORIGIN      
        1 acatgggggc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgtttcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggagtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtctgta atttcgtctg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 actccaagaa catactatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgt gagagatgcc ttcgggggcg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001182             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4258:17522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001182
VERSION     KCXD01001182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4258:17522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59664.1"
                     /translation="CVRDSSWYNWDQDFDYW"
     D_segment       407..417
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           99 a          131 c          137 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgaaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtcac tcaaatgcgc tgtctctggt
      181 ggctccatca ccgggaacta ctggagttgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtaccactga tagtggtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcatcaga cacgtccaag aaccagttct ccctggagtt gaggtctgtg
      361 accgccgcgg acacggccgt gtattattgt gtgagagata gtagttggta taactgggac
      421 caagactttg actattgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001183             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23900:15570
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001183
VERSION     KCXD01001183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23900:15570"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    130..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        130..493
     V_segment       130..423
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <415..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59665.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       437..442
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          100 a          124 c          150 g          121 t
ORIGIN      
        1 acatggggga gcccagcccc agaattccca ggtgtttctg ttcggcgatc agcactaaac
       61 acagaacaaa ccatggagtt tgtgctgagc tgggttttcc ttgttgctct tttgaaaggt
      121 gtccagtgtg aggtgcagtt ggtggagtct gggggcggct tggcaaagcc tggggggtcc
      181 ctgagactct cctgcgcagc ctctggattc agcttcagtt tctactacat gagctgggtc
      241 cgccagcctc cagggaaggg tctggagtgg atctcaggta ttaacgctgg tggggatggc
      301 acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa cgccaagaac
      361 acactgcatc ttcaaatgga cagcctgaga actgaggaca cggctgtcta tttctgtgtg
      421 agagatcgac gtgttcagtc gttatcctgg ttcgatgtct ggggcccggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001184             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13328:15462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001184
VERSION     KCXD01001184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13328:15462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59666.1"
                     /translation="CATGRIGSSGWSNLFTGLESW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          146 c          144 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaattca
      301 cgcagagaaa ttccagggca gagtcacctt gaccgaggac acgtccacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agcggctggt ccaacctctt caccggtttg gaatcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001185             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:9832:8802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001185
VERSION     KCXD01001185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:9832:8802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59667.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       446..451
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          118 c          164 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaca
      181 gccggggggg tccctgagac tctcctgttc agcctctgga ttcaccttca gtaggcactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctagag tgggtctccg gtatgaatag
      301 tggtggggat actacatact acgcagactc cgtgaagggc cgattcacca tgtccagaga
      361 caattcaaag aacactctct ccctgcaaat gaacagcctg agagcggagg acacggccgt
      421 gtattattgt gtgcaagggg aaatttttgg agtgggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001186             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11007:18719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001186
VERSION     KCXD01001186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11007:18719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59668.1"
                     /translation="CAISSSGSWLFWCFDIW"
     D_segment       424..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          143 c          134 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggccc agctggtgca gtctggggcg gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacatcttc accgaattat cgttccactg ggtgcgccag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatttgg tgaaatgata
      301 cacacagaga aattccaggg cagaatcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggaac taagcagcct gagatctgag gacacggccg tgtatttctg tgcgatatca
      421 tccagcggca gctggctatt ctggtgtttc gacatctggg gccctggcac tccaatcacc
      481 atctcttcag cc
//
LOCUS       KCXD01001187             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24429:3462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001187
VERSION     KCXD01001187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24429:3462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59669.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          136 c          129 g          111 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccag atgggtcctg tcccaggtgc agctgctgga
      121 gtcgggcccg ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcactagtt actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001188             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9001:13236
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001188
VERSION     KCXD01001188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9001:13236"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59670.1"
                     /translation="CAAGYSGSWNHWYFDFW"
     D_segment       429..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          139 c          145 g           97 t
ORIGIN      
        1 acatgggaga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcaaagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcagcgaatt gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg ggggtgttga tcctgtatat ggtgaaatga
      301 tacacgttga gaagttccag ggcagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtttttc tgtgcggccg
      421 ggtacagtgg cagctggaac cactggtact tcgatttctg ggggcctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01001189             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16354:8110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001189
VERSION     KCXD01001189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16354:8110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59671.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          109 a          146 c          134 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaagtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aggatttccg gatacacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctgtatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acttggaact
      361 gagcggcctg acttctgagg acacggccgt gtattactgt gcgactggcc ctaccggcac
      421 ctggaacgcc tggtacctcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01001190             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10338:6053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001190
VERSION     KCXD01001190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10338:6053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59672.1"
                     /translation="CARADRGSSIDFW"
     D_segment       439..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          112 c          145 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aagactcacc atgaagtttg ggctgagctg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct aagactctcc tgtgcagtct ctggattcac cttcagtacc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcggttata tcttatgatg
      301 atgataagaa atactacaca gactctttga aggaccgatt caccatatcc agagacaatt
      361 ccaagaacac tctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag agcggatcgc ggcagttcaa ttgacttctg gggccaggga gtcctggtca
      481 ccgtttcctc agcc
//
LOCUS       KCXD01001191             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23795:15165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001191
VERSION     KCXD01001191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23795:15165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59673.1"
                     /translation="CARDLNTALSYNSLDVW"
     D_segment       400..406
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..466
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          143 c          125 g          108 t
ORIGIN      
        1 atggggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagca ataactactg gacctggatc cgccaatccc cagggaaggg actggagtgg
      241 attggacgta tctctggtta tggtgacttc accgcctaca acccctccct cgagagtcga
      301 gtctccattt caaaagactc gtccaagagc caattctccc tgaaactgaa ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagatctca atacagccct ttcgtacaac
      421 tcattggatg tctggggccg gggacttctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001192             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17320:15760
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001192
VERSION     KCXD01001192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17320:15760"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59674.1"
                     /translation="CARWGTPFDYW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           90 a          135 c          131 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcttgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 agctccatca acagtggtta tgcctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggcatatcta tgatagtagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa cctgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagat gggggacccc ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001193             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23854:4707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001193
VERSION     KCXD01001193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23854:4707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..471
     V_segment       105..401
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59675.1"
                     /translation="CARWGDSQSIYYFDFW"
     D_segment       402..406
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           94 a          137 c          133 g          109 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gtgactctat taccagtagt agctggtgga actggatccg ccagccccca gggaaagggc
      241 tggaatggat tggttatatc agtggtacta gtgggagcac cgactatcac ccctccctca
      301 agagtcgagt caccatttca acagacacgt ccaagaacca gtttaccctg acgttgagtt
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag atggggcgac tcccagtcca
      421 tttactactt tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001194             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22215:2070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001194
VERSION     KCXD01001194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22215:2070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..298
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..298
     V_segment       8..237
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59676.1"
                     /translation="CARADRGSSIDFW"
     D_segment       245..251
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       257..298
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        299..>300
                     /gene="IGHG"
BASE COUNT           74 a           73 c           81 g           72 t
ORIGIN      
        1 acatggggtg cagcctctgg attcaccttc agtacctatg gcatgcactg ggtccgccag
       61 gctccagggc aggggctgga gtgggtggcg gttatatctt atgatgatga taagaaatac
      121 tacacagact ctttgaagga ccgattcacc atatccagag acaattccaa gaacactctt
      181 tatcttcaaa tgaacaacct gaaattggag gacacggccg tgtattattg tgcgagagcg
      241 gatcgcggca gttcaattga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001195             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10426:10967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001195
VERSION     KCXD01001195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10426:10967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59677.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          123 c          160 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa tataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcaacttc aattactact
      241 acatgaactg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaca
      301 gtggtgggga tagcacatac tatgcggact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcgagagtg gtgggtggtg ccgcaggata cttcgacttc tggggccagg
      481 gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001196             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13402:20486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001196
VERSION     KCXD01001196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13402:20486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59678.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       405..417
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           90 a          142 c          126 g          112 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctgctg
      181 actccatcac cagtagcttc tggaactgga tccgccagcc cccagggagg gggctggagt
      241 ggattggcta tatctctggt gctactggga gttccagcta caacccctcc ctcaagagtc
      301 gagtctccat ttcaacagac acgtccaata accagttttc cctgaagctg aactctgtga
      361 ccgccgcgga caccgccgtg tattactgtg cgagatatga cgacgatgat tacggttctt
      421 attaccttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001197             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19998:20851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001197
VERSION     KCXD01001197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19998:20851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..332
     V_segment       24..271
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <263..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59679.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       272..277
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..332
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           85 a           95 c           85 g           69 t
ORIGIN      
        1 acatgggaca caaccaccac atccctccgt gaaaatctcc tgccaagctt ctggatacac
       61 cttaaccgac cactacctgc actgggtgcg acaggctcct ggaaaaggac ttgagtggat
      121 gggaggtgtt catcctgaat atggtaaagt agactacaca cagaagttcc gagacagagt
      181 caccatcacc gcggacatgt cgacagagac agcctacatg gagctgagca gcctgagatc
      241 tgaggacacg gccgtttatt actgtgtgac agtgggtccc taccattact ttgacttctg
      301 gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001198             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14493:19154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001198
VERSION     KCXD01001198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14493:19154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..490
     V_segment       139..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <424..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59680.1"
                     /translation="CANALSGGLDYW"
     D_segment       439..444
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          100 a          124 c          161 g          107 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcacc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggcggctt ggcaaagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag gtactggatg
      241 aactgggtcc gccaggcgcc agggaagggg ctggagtggg tctcagctat tactagtggt
      301 ggcgacagca catactacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 tctaagaata cgctctccct gcaaatgaac agccttagag cggaggacac ggccgtgtat
      421 tactgtgcga acgcgttaag tggggggctt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001199             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:12317:5331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001199
VERSION     KCXD01001199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:12317:5331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59681.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       413..424
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          112 a          100 c          141 g          114 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgaagc
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc tctgagactc tcctgtgcag
      181 cttccggatt caccttcagt ttctatggca tgcactgggt ccgcctggct ccagggaagg
      241 ggctggagtg ggtggcagtt acatcgaatg atgaaagtaa gaaatactac ggagactctg
      301 tgaaggaccg attcaccatc tccagagaca attccaagaa catactatat cttcaaatga
      361 acaacctgaa attgaaggac acggccgtgt actactgtgg gagagatgat aatggggtga
      421 ttatcgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001200             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22613:13100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001200
VERSION     KCXD01001200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22613:13100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59682.1"
                     /translation="CARGTGAILVYFDHW"
     D_segment       434..440
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          125 c          152 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgaga tacaactggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ctcagacact actatatgac
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtgatgg
      301 gagtggcaca tactatgcag actccgtgaa ggacagattc accatctcca gagacaacgc
      361 caagaacaca ctgtctcttc aaatggacag cctgacagct gaggacacgg ctgtctatta
      421 ctgtgcgagg gggactgggg cgattcttgt gtactttgac cactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001201             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:24168:12373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001201
VERSION     KCXD01001201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:24168:12373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59683.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..448
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          102 a          124 c          154 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacaaaccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagttggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcagct tcagtttcta ctacatgagc
      241 tgggtccgcc agcctccagg gaagggtctg gagtggatct caggtattaa cgctggtggg
      301 gatggcacat actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaacacac tgcatcttca aatggacagc ctgagaactg aggacacggc tgtctatttc
      421 tgtgtgagag atcgacgtgt tcagtcgtta tcctggttcg atgtctgggg cccgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001202             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16870:8308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001202
VERSION     KCXD01001202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16870:8308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59684.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       425..432
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          105 a          138 c          145 g          100 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg atgtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgcaa ggcttctgga ttcgccttca gaatgtatgc cctcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag ggatcgtccc tcttgttgga acaacaaact
      301 ccgcacagaa gttccagggc agagtcacga ttaccgcgga cacgtccaca agcacagtct
      361 acatggagtt gagcagcctg agatctgagg acacggccat gtattactgt gcgagaggcc
      421 tgggtagcag cgcccacttt ggtttggatt cctggggcca aggggtcgtc gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01001203             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15616:15447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001203
VERSION     KCXD01001203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15616:15447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59685.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       415..430
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          101 a          142 c          126 g          105 t
ORIGIN      
        1 acatggggtc cctcaccgca cagctgggat ctcagttctt catttctgtc ctccaccacg
       61 atggggtcaa ctgccatcct cgccctcctc ctggctgttc tccaaggagt ctgtgccgag
      121 gtgaaactgg tgcagtctgg ggcagaggtg agaaggcccg gggagtctct gaagatctcc
      181 tgtaagactt ctggatacag ctttaccacc aactggatca gttgggtgcg ccagacgccc
      241 ggaaaaggcc tggaatggat ggggaccatc tatcctgctg attctgaggc caaatacaac
      301 ccgtccttcc aaggccacgt cactatctca gccgacaagt ccatcagtac cacctacctg
      361 cagtggagca gcctgaaggc ctcggacacc gccacgtatt tctgtgcgaa aacctactat
      421 agtggtagtt tggaaatctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001204             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:25459:5617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001204
VERSION     KCXD01001204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:25459:5617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59686.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          148 c          136 g           95 t
ORIGIN      
        1 acatggggtt cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccttcac cgaattagcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cattgatcct gcgtatggtg agtttacacc
      301 cggagagaag ctccagggca gactcaccat gaccgaggac acgtctatag acacagccta
      361 cttggacctg accagcctga actctgagga cacggccgtc tattactgtg ctgccgggta
      421 tagcggcagc tggaaccact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001205             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27385:11720
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001205
VERSION     KCXD01001205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27385:11720"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59687.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       448..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          112 a          121 c          159 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcttga caaagcctgg
      181 ggggtccctg agactctcct gtgcggcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgaatca gtcatgatgg
      301 tgatagcaca tggtacgcag actccgtgaa ggacagattt accatttcca gagagaatgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gaggacacag ccgtatatta
      421 ctgtgcgaga gagcgttttg ggggaattgg ggtgattatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01001206             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18372:10659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001206
VERSION     KCXD01001206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18372:10659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59688.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          143 c          133 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aaccctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacttggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacctc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001207             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:7279:6400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001207
VERSION     KCXD01001207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:7279:6400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..480
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59689.1"
                     /translation="CARRGYNNADDWYFDFW"
     D_segment       409..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          106 a          144 c          136 g           96 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgca gtccggggct gaggtgaagg agcctggggc ctcagtgaag ctctcctgcc
      181 aggcttctgg atacaccttc ggcatctacg ccatcaattg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcaccc ctcttattgg cttaacaaac tacgcacaga
      301 agttccaggg cagagtcacg ctcaccgcgg acacgtccac aagtacagtc tacatcgagt
      361 tgaacagcct gagatctgag gacacggccg tgtatttctg tgcgagacgt ggatacaaca
      421 acgctgacga ctggtacttc gatttctggg gccctggcac cccgatcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01001208             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24859:8739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001208
VERSION     KCXD01001208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24859:8739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59690.1"
                     /translation="CARDRLGGGWFDYW"
     D_segment       409..420
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           92 a          134 c          137 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctacaggagt
      121 cgggcccagg agtggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cgatagttac aggtggagct ggatccgtca gcccccaggg aaggaactgg
      241 agtggatagg gtacatctat ggtggtaata cgggcaccaa ctacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaaa gacacgtcca cgaaccagtt ctccttgaaa ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattcct gtgcgagaga tcggcttggc ggtggctggt
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001209             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22340:13769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001209
VERSION     KCXD01001209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22340:13769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..483
     V_segment       120..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59691.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       422..429
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..483
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          104 a          137 c          144 g          100 t
ORIGIN      
        1 acatgggaca taacaaccac gtccctcctc taaagaagcc cctgggaaca cagctcatca
       61 ccatggactt gacctggagg ctcctctttg tggtggcagc agctacaggt gcccagtccc
      121 aggtccagct ggtgcagtcc ggggctgatg tgaagaagcc tggggcctca gtgaagctct
      181 cctgcaaggc ttctggattc gccttcagaa tgtatgccct cagttgggtg cgacaggccc
      241 ctggacaagg gcttgagtgg atgggaggga tcgtccctct tgttggaaca acaaactccg
      301 cacagaagtt ccagggcaga gtcacgatta ccgcggacac gtccacaagc acagtctaca
      361 tggagttgag cagcctgaga tctgaggaca cggccatgta ttactgtgcg agaggcctgg
      421 gtagcagcgc ccactttggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01001210             325 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:3196:14623
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001210
VERSION     KCXD01001210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 325)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 325)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:3196:14623"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..323
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..323
     V_segment       8..249
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <242..>292
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59692.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       262..270
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       271..323
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        324..>325
                     /gene="IGHG"
BASE COUNT           76 a           70 c          101 g           78 t
ORIGIN      
        1 acatggggtg aaggtctcct gcaaggtttc cggatacagt gtcaccgaat tatcgattca
       61 ctgggtgcga caggcccctg gaaaagggct tgagtggatg ggaggtgttg atcctgtaaa
      121 aggtgaagaa attcacggag aggagttcca ggacagagtc accatgaccg aggacccgtc
      181 tacagacaca gcctacatgg agttgagcaa cctgagatct gaggacacgg ccgtgtatta
      241 ttgtgcgagt gggtttagta tctggttatt ttacgacgtt ttggattcct ggggccaagg
      301 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001211             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21851:10069
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001211
VERSION     KCXD01001211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21851:10069"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59693.1"
                     /translation="CVTDARGSGLDSW"
     D_segment       442..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          118 c          156 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcgggga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg actcaccttc agtaactatg
      241 gcctgcactg ggtccgccag gctccaggaa aggggctgga gtgggtggca gtcacatcgt
      301 ctgatgggag taagaaatac tacgcagact ctgtgaaggg ccgattcacc atctccagag
      361 acaatttcaa gaacatgctt tatcttcaaa tgaacagcct gaaattggaa gacacggccg
      421 tttattactg tgtgacagat gcgaggggtt ccggtttgga ttcctggggc ccaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001212             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5865:16200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001212
VERSION     KCXD01001212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5865:16200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..485
     V_segment       128..421
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59694.1"
                     /translation="CARKFEYKKSLDVW"
     D_segment       428..434
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          131 c          142 g           99 t
ORIGIN      
        1 acatggggga gcatcacata acaaccacgt ccctcctcta aagaagcccc tgggaacaca
       61 gctcatcacc atggacttga cctggaggct cctctttgtg gtggcagcag ctacaggtgg
      121 ccagtcccag gtccagctag tgcaatccgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaagctctcc tgcaaggctt ctggattccc cttcaacatc tatggcatca gttgggtgcg
      241 acaggcccct ggacaagggc ttgagtggat gggaaggatc atcccgcttg gtgatataac
      301 aacgtacgct cagaagttcc aggacagagt cacgattacc gcggacacgt ccacaggcac
      361 agcctacatg gagctgcgaa gtctgagatc tgaggacacg gccgtgtatt actgtgcgag
      421 aaaattcgaa tacaagaagt cattggatgt ctggggccgg ggagttctgg tcgccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001213             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10363:18390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001213
VERSION     KCXD01001213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10363:18390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59695.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          117 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatttcgt
      301 atgatgaaac taagaaatac ttcgcagact ctgtgaggga ccggttcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001214             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:15568:13340
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001214
VERSION     KCXD01001214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:15568:13340"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..502
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59696.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       438..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          119 c          158 g          118 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcagttg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtctc tgagactctc ctgtgtaggc tctggattca gcttcagaag ttacgaaatg
      241 agttgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagtcacact
      301 ggtgaaacca tataccacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tactgtacta gaaaccggaa tactgtcatg attgggtggt tcgatgtctg gggcccggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001215             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14551:14459
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001215
VERSION     KCXD01001215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14551:14459"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..491
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59697.1"
                     /translation="CARVVYYDSSYSTSPYNRFDVW"
     D_segment       424..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          109 a          140 c          142 g          106 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg gtacaccttc agcatctatg ccatcagttg ggtgcgacag gcccctgggc
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg tataacaaat tacgcacaga
      301 ggttccaggg cagagtcacc attaccgcgg acacgtccac aagcacagcc tacatagacc
      361 tgagtagcct gagatctgag gacacggccg tgtattactg tgcgagagtt gtatactatg
      421 atagtagtta ttccacgagt ccctacaacc ggttcgatgt ctggggcccg ggagtcctag
      481 tcaccgtctc cccagcc
//
LOCUS       KCXD01001216             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20387:4136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001216
VERSION     KCXD01001216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20387:4136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..456
     V_segment       105..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59698.1"
                     /translation="CAGGSRRQPENW"
     D_segment       407..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           83 a          132 c          141 g          102 t
ORIGIN      
        1 acatgggggg atgctctctg agagtcacgg acctcctatg caagagcatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctt
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtatatcggt ggtactagtg ggagtaccta ctacaatccc tccctcgaga
      301 gtcgagtcac catttcaaca gacacgtcca agaatctctt ctccctgaag atgagttctt
      361 taaccgccgc ggacacggcc atgtatttct gtgcgggcgg aagtcggcgg cagccggaga
      421 actggggcca gggagtcctg gtcaccgtct cttcagcc
//
LOCUS       KCXD01001217             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17463:6155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001217
VERSION     KCXD01001217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17463:6155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59699.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          124 c          147 g          104 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acagtgtcac cgaattatcg attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aagaaattca
      301 cggagaggag ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagctg agcaacctga gatctgagga cacggccgtg tattattgtg cgagtgggtt
      421 tagtatctgg ttattttacg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001218             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16330:8936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001218
VERSION     KCXD01001218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16330:8936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..400
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59700.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       406..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          142 c          131 g          109 t
ORIGIN      
        1 acatggggat gctgtctgag agtcagggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc aggtcccaga tgggtcctgt cccagccgca gctgcagctg
      121 caggagtcgg gcccaggact ggtgaaacct tcggagaccc tgtccctcgc ctgcgttgtc
      181 tctggtggct ccatcagcga ttactcctgg agctggatcc gccagccccc agggaaggga
      241 ctggagtgga ttgggaatat tgatgttcat ctagcgggcc ccaactacaa cccctccctc
      301 aagagtcgag tcgccatttc aaaagacacg tccaagaatc agttctccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtatat ttctgtgcga aacaatatag tggtagttat
      421 tactactccc actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001219             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20183:18993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001219
VERSION     KCXD01001219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20183:18993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59701.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       407..414
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           84 a          143 c          137 g          102 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcgcctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggttact cctggagctg gatccgccag cccccaggca agggtctgga
      241 gtggattgga catgtcagtg gtagtagtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gcgccagttc tccctgaggc tgatttctgt
      361 gaccgccgcg gacacggccg tctatcattg tgcgagagtc cggggcgtga ctatctatta
      421 ctttgactac tggggccagg gagccctggt caccgtcgcc tcagcc
//
LOCUS       KCXD01001220             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8477:3518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001220
VERSION     KCXD01001220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8477:3518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59702.1"
                     /translation="CTRYGGDRGDWYFDYW"
     D_segment       416..422
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           91 a          138 c          138 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggagctgg gtccgccagc ccccagggaa ggggctggac
      241 tggattgggt atatctatgg tggtagtggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaaact gaactctctg
      361 accgccgcgg acaccgccgt gtattactgc acgagatatg ggggagatcg gggcgactgg
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001221             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21078:9664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001221
VERSION     KCXD01001221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21078:9664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59703.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       445..450
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          108 a          128 c          151 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagt acctattcta
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagct attagtactg
      301 ctggtagcac atactacaca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgagagt tgaggacacg gccctgtatt
      421 actgtgcgaa aggggagaca gcctcagttt attacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001222             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:4368:6665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001222
VERSION     KCXD01001222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:4368:6665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..454
     V_segment       100..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59704.1"
                     /translation="CARWSAANFDYW"
     D_segment       401..407
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           90 a          133 c          136 g           97 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacctc ctgggcaaga acatgaggca tctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcaact gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgatgt ctctgggggc
      181 tccatcagca gtggttatgg ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt gtatctacga tagtagtgga aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaaaaga cacgtccaag aaccagttct ccctgaagct gaggtctatg
      361 accgccgcgg acgcggccgt gtattactgt gcgagatggt cggcagccaa ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001223             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12198:17799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001223
VERSION     KCXD01001223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12198:17799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..283
     V_segment       9..222
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <214..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59705.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       226..232
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       241..283
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           76 a           68 c           74 g           67 t
ORIGIN      
        1 acatggggca ccttcagtaa ctttggcata cactgggtcc gccaggctcc agggaagggg
       61 ctggagtggg tgacagttat ttcgtctgat ggaactaaca aatactacgc aaactctgtg
      121 aagagccgat tcaccatctc cagagacaat tccaagaaca tactatatct tcaaatgaac
      181 aacttgaaat tggaggacac ggccgtctat tactgtgcga gagatgatat tgggaccggt
      241 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001224             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12693:13953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001224
VERSION     KCXD01001224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12693:13953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59706.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          144 c          132 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagttact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctagaat ggagcagcct gaaggcctcg gacaccgcca cgtatttttg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagccctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01001225             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13159:8402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001225
VERSION     KCXD01001225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13159:8402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59707.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       437..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..501
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          140 c          147 g          112 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 ccactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttcttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcgaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcaac acctatgcta
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagct attagtactg
      301 ctggtagcac atactacgca gactccgtga agggccgctt caccgtctcc agagacaact
      361 caaagaacac gctctccctc caagtgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgcgaa aggaggtagc agctctttct actggtactt cgatatccgg ggccctggca
      481 ccccagtcac catctcctca gcc
//
LOCUS       KCXD01001226             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22409:18830
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001226
VERSION     KCXD01001226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22409:18830"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..491
     V_segment       131..421
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <413..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59708.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       424..439
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          100 a          126 c          153 g          114 t
ORIGIN      
        1 acatggggga gcccagcact ggaagtccac agtgttccat tcggtgatca gcactgaaca
       61 cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta ttttaagtgg
      121 tgtccagtgt gaggtgcagg tggtggagtc tgggggcggc ttggcaaagc ccgggggatc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt acctatgcta tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtctcagcc attagtgttg gtggtagtac
      301 atactacgca gactccgtga ggggccgatt caccatctcc agagacaact cagagaacac
      361 gctctccctg cacatgaaca gcctgacagc tgaggacacg gccgtgtatt actgtgcgaa
      421 aggggataca gctacagttt attacggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001227             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15527:14560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001227
VERSION     KCXD01001227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15527:14560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59709.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       407..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          136 c          139 g          107 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag gtgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tgactccttc agcggttact actggagctg gatccgccag tccccaggga cggggctgga
      241 gtggattggg tatatcagtg ctagtagtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag aaatattata gtggtagtta
      421 taaacacaac tggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001228             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25808:13401
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001228
VERSION     KCXD01001228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25808:13401"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59710.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       424..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          143 c          143 g          103 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatccacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgct cctctatatg gtgaaatgat
      301 gctcgcagac aacttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga cgacacggcc gtgtattact gtgcgcgtgg
      421 gcctattaca atttttggcg tacttattac ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001229             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:23448:5099
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001229
VERSION     KCXD01001229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:23448:5099"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59711.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           96 a          146 c          146 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagttg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001230             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:26900:18189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001230
VERSION     KCXD01001230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:26900:18189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59712.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       406..413
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           83 a          143 c          136 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttactc ctggagctgg atccgccagc ccccaggcaa gggtctggag
      241 tggattggac atgtcagtgg tagtagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag cgccagttct ccctgaggct gatttctgtg
      361 accgccgcgg acacggccgt ctatcattgt gcgagagtcc ggggcgtgac tatctattac
      421 tttgactact ggggccaggg agccctgttc accgtcgcct cagcc
//
LOCUS       KCXD01001231             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11666:3562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001231
VERSION     KCXD01001231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11666:3562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..488
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59713.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       429..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>492
                     /gene="IGHG"
BASE COUNT           98 a          145 c          137 g          112 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa tggtctctga gagtcatggg cctcctgtgc
       61 aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc acctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 ctcacctgcg ctgtctctgg tgactccatc accaatacct actggaactg gatccgccag
      241 cccccaggga aggggctgga gtggattgga tttatctatg gtgctactgg gagcaccggc
      301 tacaacccct ccctcaagag tcgagtcacc atctcaacag acacgtccaa gaaccagttt
      361 tccctgaagc tgagctctgt gaccgccgcg gacaccgccg tgtattattg tgcgagatat
      421 gatcagtggg atgattacct gtactacttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcgt cc
//
LOCUS       KCXD01001232             527 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23945:3596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001232
VERSION     KCXD01001232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23945:3596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..525
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..525
     V_segment       144..436
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>494
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59714.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       451..470
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       483..525
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        526..>527
                     /gene="IGHG"
BASE COUNT          114 a          132 c          155 g          126 t
ORIGIN      
        1 acatgggggc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag tgtgaggtgc aactggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttacg
      241 acatgacctg ggtccgccag gctccgggaa aggggctgga atgggtctca tatattagtt
      301 acactggtaa aaccatatac tactctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgccaa gaactctctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattattg ttctagagcg gcttacgaac atgatgacgg ttactattac gtcggcaggt
      481 tttttgactg ctggggccag ggagcccagg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001233             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9372:5441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001233
VERSION     KCXD01001233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9372:5441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59715.1"
                     /translation="CTRDVYGSGFDYW"
     D_segment       439..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          113 c          152 g          122 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctac
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggcc tggttcagcc
      181 tcgggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gttttggcat
      241 gcactgggtc cgacaggctc cagggaaggg gctggagtgg gtggcagtta tgtcgtctga
      301 cggaagtagg atatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 tttcaagaac atgctatatc ttcaaatgaa caacctgaaa tttgaggaca cggccgtgta
      421 ttattgtacg agagatgtct acggtagtgg atttgactac tggggcctgg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001234             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7914:18218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001234
VERSION     KCXD01001234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7914:18218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59716.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       407..413
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          135 c          134 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacagac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag ggctggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gagagtacta ttggagctgg atccgccagg ccccagggaa gggactggag
      241 tggattggct acatctatgg taacattggg agcaccagct ataacccgtc cctccagagt
      301 cgagtcaccg tttcaataga cacgtccaag aatcacttct ccctgaagtt gacgtctgtg
      361 accgccgcgg acacggccgt atatcactgt gcgagacatc tctattcctg gaaagggaag
      421 tggatcgatg tctggggccc gggagtcctg atcaccgtct cctcagcc
//
LOCUS       KCXD01001235             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18844:4748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001235
VERSION     KCXD01001235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18844:4748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..298
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..298
     V_segment       8..237
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59717.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       243..249
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..298
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        299..>300
                     /gene="IGHG"
BASE COUNT           73 a           77 c           81 g           69 t
ORIGIN      
        1 acatggggtg cagcctctgg attcaccttc agtacctctg gcatgcactg ggtccgccag
       61 gctccaggga aggggctgga gtggctgaca gttatatcgt atgatgaaac taagcaatac
      121 tacgcagact ctgtgaagga ccgattcacc atctccagag acaattccaa gaacatgcta
      181 tatcttcaaa tgaacaacct gaaattggag gacgcggccg tgtattactg tgcgagagat
      241 tcttacggtc gaggctttga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001236             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10423:12952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001236
VERSION     KCXD01001236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10423:12952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59718.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          121 a          139 c          136 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagcgaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatat tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001237             342 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15648:16988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001237
VERSION     KCXD01001237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 342)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 342)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15648:16988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..340
     V_segment       7..279
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <271..>309
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59719.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       280..285
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       295..340
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>342
                     /gene="IGHG"
BASE COUNT           85 a           90 c           98 g           69 t
ORIGIN      
        1 acatgggggg ctgaggtgaa gaagcctggg gcctccgtga aaatctcctg ccaggcttct
       61 ggatacacct taaccgacca ctacctgcac tgggtgcgac aggctcctgg aaaaggactt
      121 gagtggatgg gaggtgttca tcctgaatat gggaaagtag actacacaca gaagttccaa
      181 gacagagtca ccatcaccgc ggacatgtcg acagagacag tctacatgga gctgagcagc
      241 ctgagatctg aggacacggc cacttattac tgtgtgacag tgggtcccta ccattacttt
      301 gactactggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001238             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15817:3592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001238
VERSION     KCXD01001238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15817:3592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59720.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           94 a          148 c          146 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgcttgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtctcc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001239             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12333:3344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001239
VERSION     KCXD01001239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12333:3344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59721.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          143 c          135 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggat tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 cccaggaaga ggccttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaga tctgaggaca cggccgtata ttactgtgcg atcggcccta gcggcagttg
      421 gaacgcctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01001240             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17779:18703
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001240
VERSION     KCXD01001240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17779:18703"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59722.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          103 a          124 c          152 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcctc cggattcacc ttcagtgacc actgcatgca
      241 ctgggtccgc caggcttcag ggaaggggct ggaatgggtc tcaggtatta cttatactgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctatatcttc aaatggacag cctgagtact gaggacacgg ctgtctattt
      421 ctgtgtggga ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001241             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17165:18294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001241
VERSION     KCXD01001241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17165:18294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59723.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       431..437
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          112 a          117 c          146 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcatctt cagtaactat gccatgcact
      241 gggtccgcca ggctccaggg aaggggctag agtgggtggc agttatttcg catgatggaa
      301 ctaagaaata ctacacagac tctgcgaagg accgattcac catctccaga gacaattcca
      361 agaacataca atatcttcac atgaacagcc tgaaattgga ggacacggcc atatactact
      421 gtgcggcctc ctacttgggg tacggttttg agtactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001242             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:26748:15296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001242
VERSION     KCXD01001242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:26748:15296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59724.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          143 c          144 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctgggtct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001243             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20486:2777
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001243
VERSION     KCXD01001243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20486:2777"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59725.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          129 c          140 g          111 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccgggcct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg atttaccttc gacaactatg gaatcaactg ggtgcggcag
      241 gcccctggac aagggcttga gtggatggga gtggtcatcc cccttgttgg tattattaat
      301 tatgcagaga acttccaggg cagagtaagg attaacgcgg acacgtccat aaacacagcc
      361 ttcatggagt tcaggagcct gagatctgac gacacggcca tttacttctg tgcgagagaa
      421 tactgtacaa ctactgattg cgccgggttc tttgactact ggggccaggg agtcatggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001244             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21173:11792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001244
VERSION     KCXD01001244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21173:11792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59726.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       440..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          112 a          128 c          148 g          117 t
ORIGIN      
        1 acatgggggc tctgggaaag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca attggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctcagac tctcctgtgc agcctctgga ttcaccttca gtacctattc
      241 tatacactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtac
      301 tgctggtagc acatactaca cagactccgt gaagggccga ttcagcatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagcctgaga actgaggaca cggccctgta
      421 ttactgtgcg aaaggggaaa cagcttcagt ttattacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001245             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:11114:16928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001245
VERSION     KCXD01001245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:11114:16928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59727.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          136 c          128 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgtcagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg ttcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001246             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:25391:14100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001246
VERSION     KCXD01001246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:25391:14100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59728.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       414..420
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          138 c          143 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgaagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccatcagc actcactcct ggagctgggt ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggcg cacggactac aatccctccc tcaagagtcg
      301 agtcaccttt tcaacagaca cgtccaggaa ccagttgtcc ctgaggctga cgtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagttgaa agcgcctggt ccgtggggtg
      421 ggattactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001247             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21625:14372
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001247
VERSION     KCXD01001247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21625:14372"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59729.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       442..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          108 c          156 g          118 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 gggggggtcc ctgagactct cctgtgcagc ttcggggttc atcttcagta gttatggcat
      241 gcactgggtc cgcctggctc cagggaaggg gctggagtgg gtggcagtaa catcgtctga
      301 tgaaagtaag aaattctacg gagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttcccagaac atactatatc ttcaaatgaa caacctgaaa ttgaaggaca cggccgtcta
      421 ctattgtggg agagatgata atggggtgat tattgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001248             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16876:10355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001248
VERSION     KCXD01001248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16876:10355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59730.1"
                     /translation="CARWGTPFDYW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           88 a          134 c          133 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtag
      181 ctccatcaac agtggttatg cctggagctg gatccgccag cccccaggga aggggctgga
      241 gtgggttggg catatctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001249             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10254:12872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001249
VERSION     KCXD01001249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10254:12872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59731.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          120 c          148 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctttcctgtg cagcctctgg attcaccttc agttcctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tttattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 cggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001250             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14948:4075
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001250
VERSION     KCXD01001250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14948:4075"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59732.1"
                     /translation="CARDEGEVSGYRFGYW"
     D_segment       453..460
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          111 c          161 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaaa atctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaacatgcta taccttcaaa tgaacaacct gagattggag gacacggcca
      421 tcttttactg tgcgagggat gagggggagg ttagtgggta tcgatttggc tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001251             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20344:19292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001251
VERSION     KCXD01001251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20344:19292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59733.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          113 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctc gttggtattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tctggcatgc
      241 actgggtccg ccaggctccg gggaaggggc tggagtgggt ggcagttaaa tcgcatgatg
      301 gaactaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001252             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12843:12591
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001252
VERSION     KCXD01001252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12843:12591"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59734.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          128 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggtccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccaggcaagg gactggagtg
      241 gattggatat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcgacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001253             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14348:12140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001253
VERSION     KCXD01001253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14348:12140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..492
     V_segment       141..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59735.1"
                     /translation="CANALTGGLDYW"
     D_segment       439..447
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          103 a          126 c          157 g          108 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 ccactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aggtactgga
      241 tgaactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagct attactagtg
      301 gtggggatag cacgtactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaaaaa cacgctctcc ctgcaaatga acagccttag agcggaggac acggccgtgt
      421 attactgtgc caacgcatta actggggggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001254             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16616:13145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001254
VERSION     KCXD01001254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16616:13145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59736.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       434..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          113 a          110 c          157 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaagtaagaa atactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacag gctatatctt caaatgaaca acctgaaatt ggaggacacg gcagtgtatt
      421 actgtgcgag agatgatagt ggggtgatca tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01001255             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8107:18446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001255
VERSION     KCXD01001255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8107:18446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..514
     V_segment       133..426
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <418..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59737.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       436..442
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          109 a          117 c          154 g          136 t
ORIGIN      
        1 acatggggga gccacagccc cgggattccc agctgtctcc acttggtcat gaacactgaa
       61 ctcagaagac gcaccatgga gtttgtgctg agtttgcttt tccttgttgc ttttttaaaa
      121 ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggtaaa gcctgggggg
      181 tccctgagac tctcttgtgt agtctctgga ttctccttca gtaactatgt tatgcattgg
      241 gtccgccagg ctccaggaaa gtgtctggag tgggtctcac ttattagtgg aagtggtggt
      301 accacagact acgcagactc tgtgaagggc cgattcaccc tctccagaga caacgccaag
      361 gaatcgcttt ttctgcaaat gaacagccta agagccgagg acacggccgt gtattactgt
      421 gctagaggcg gggaaatagt ggattcagag attattgagg attactacgg tttggatttc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001256             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18077:17032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001256
VERSION     KCXD01001256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18077:17032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59738.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          139 c          135 g           93 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaag tccaaggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcgtcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcgtcagcc
//
LOCUS       KCXD01001257             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13820:8533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001257
VERSION     KCXD01001257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13820:8533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..493
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59739.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       442..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          108 a          118 c          152 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc gttcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaattttgg
      241 catgcactgg gtccgccaga ctccagggaa ggggctggag tgggtggcag ttatatcgca
      301 tgatagaaat aatatatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcgaag aacatgctgt atcttcaaat gaacaaccta cagttggagg acacggccgt
      421 gtattcctgt gtgcgagatg cctacggtac cgggttggat tcctggggcc aaggcgtcgt
      481 cgtcatcgtc tccccagcc
//
LOCUS       KCXD01001258             410 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21612:10919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001258
VERSION     KCXD01001258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 410)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 410)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21612:10919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    45..408
                     /note="immunoglobulin heavy chain variable region"
     V_region        45..408
     V_segment       45..338
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <330..>377
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59740.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       348..358
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       367..408
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        409..>410
                     /gene="IGHG"
BASE COUNT           86 a          105 c          119 g          100 t
ORIGIN      
        1 acatgggggt tttccttgtt gctattttaa gaggtgtcca gtgtgaggtg caactggtgg
       61 agtctggagg aggcttggtc cagcctgggg ggtccctgag actctcctgt acagccactg
      121 gattcacctt cagtagtttt ggcatgagct gggtccgcca gcctccaggg aaggggctgg
      181 agtgggtctc atacattagt aatagtggta gtagcacata ctacgcagac tccgtgaagg
      241 gccgattcac catctccaga gacaactcaa agaacacgct ctccctgcaa atgaacagcc
      301 tgacagctga ggacacggcc gtgtatcact gtgcgaaaca tcgtttcagc agctggtcgt
      361 atttccttga cttctggggc cagggaatcc tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01001259             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11129:12420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001259
VERSION     KCXD01001259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11129:12420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59741.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          135 c          137 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccttcagc ggtttctatt ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggtat atcagtgcta gtagtgggag taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaataa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtccaggtc accgtctcct cagcc
//
LOCUS       KCXD01001260             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:27657:10159
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001260
VERSION     KCXD01001260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:27657:10159"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..447
     V_segment       93..386
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <378..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59742.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       387..392
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT          107 a          127 c          129 g           86 t
ORIGIN      
        1 acatggggag aagccccaga gcacagcacc tcaccatgga ctggacctgg aggctcctcc
       61 tcttggtggc agcagctaca ggcgcccact ccgaggtcca gctggtacag tctggggctg
      121 aggtgaagaa gcctggggcc tccgtgaaaa tctcctgcca ggcttctgga tacaccttaa
      181 ccgaccacta cctgcactgg gtgcgacagg ctcctggaaa aggacttgag tggatgggag
      241 gtgttcatcc tgaatatggg aaagtagact acacacagaa gttccaagac agagtcacca
      301 tcaccgcgga catgtcgaca gagacagtct acatggagct gagcagcctg agatctgagg
      361 acacggccac ttattactgt gtgacagtgg gtccctacca ttactttgac tactggggcc
      421 agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001261             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10625:2941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001261
VERSION     KCXD01001261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10625:2941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59743.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          116 a          143 c          130 g           89 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggga aagtagacta
      301 cacacagaag ttccaagaca gagtcaccag caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccact tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001262             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11461:7589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001262
VERSION     KCXD01001262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11461:7589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59744.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       405..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           89 a          143 c          130 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactgctgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccagtggctt ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatctctgg tgctactggg agtaccagct acaccccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gcactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgcggatga ttacggttat
      421 tattaccttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001263             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8979:9981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001263
VERSION     KCXD01001263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8979:9981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59745.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       438..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          118 c          152 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtttc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctggggag tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgtctg taatttcgtc
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caactccaag aacatactat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001264             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:26860:9917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001264
VERSION     KCXD01001264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:26860:9917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..420
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <412..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59746.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       421..426
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          116 a          143 c          132 g           92 t
ORIGIN      
        1 acatggggag agcatcacac aaccaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggctc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactccgagg tccagctggt acagtctggg gctgaggtga agaagcctgg ggcctccgtg
      181 aaaatctcct gccaggcttc tggatacacc ttaaccgacc actacctgca ctgggtgcga
      241 caggctcctg gaaaaggact tgagtggatg ggaggtgttc atcctgaata tggtaaagta
      301 gactacacac agaagttccg agacagagtc accatcaccg cggacatgtc gacagagaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtttatta ctgtgtgaca
      421 gtgggtccct accattactt tgactactgg ggccagggag ccctggtcac cgtttcctca
      481 gcc
//
LOCUS       KCXD01001265             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21715:8850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001265
VERSION     KCXD01001265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21715:8850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59747.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          124 c          159 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact caacacagaa cataccatgg agtatgtgct gagttgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 aacctggggg gtccctgaga ctctcctgcg cagcctctgg attcaacttc aattactact
      241 acatgaactg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaca
      301 gtggtgggga tagcacatac tatgcggact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcgagagtg gtgggtggtg ccgcaggata cttcgacttc tggggccagg
      481 gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001266             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7943:7379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001266
VERSION     KCXD01001266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7943:7379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59748.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       443..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          109 c          153 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cttcgggttt catcttcagt agttatggca
      241 tgcactgggt ccgcctggct ccagggaagg ggctggagtg ggtggcagta acatcgtctg
      301 atgaaagtaa gaaattctac ggagactctg tgaaggaccg attcaccatc tccagagaca
      361 attcccagaa catactatat cttcaaatga acaacctgaa attgaaggac acggccgtct
      421 actattgtgg gagagatgat aatggggtga ttattgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001267             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7640:8373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001267
VERSION     KCXD01001267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7640:8373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59749.1"
                     /translation="CATGYSGSWNHWYFDVW"
     D_segment       408..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          115 a          141 c          132 g           91 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgacttatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgaccc tgcatatggt gaaatgaaac
      301 acgtagacag ggtctccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgac atctgaggac acggccgtgt attactgtgc aaccggatat agtggcagct
      421 ggaaccactg gtacttcgat gtctggggcc ctggcacccc agtcaccatc tcctcagcc
//
LOCUS       KCXD01001268             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9076:19933
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001268
VERSION     KCXD01001268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9076:19933"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..429
     V_segment       75..368
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59750.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       374..379
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       388..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           96 a           93 c          133 g          109 t
ORIGIN      
        1 acatgggagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
       61 gaggtgtcca gtgtgaagtg caactggtgg agtctggagg aggcttggtt cagccggggg
      121 ggtccctgag actctcctgt gcagcctctg gattcagctt cagtggcttt ggcatgcact
      181 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg tatgatgaaa
      241 ctaagaaata ttacgcagac tctgtgaagg accgattcac cgtctccaga gacaattcca
      301 agaacatgct atattttcaa atgaacaacc tgaaattgga agacacggcc gtgtattact
      361 gtgcgagaga tgtctatggc aggggacttg actactgggg cctgggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01001269             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16186:18831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001269
VERSION     KCXD01001269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16186:18831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59751.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       438..443
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          110 c          154 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga agtgcaactg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gcttcagtgg ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtatgat
      301 gaaactaaga aatattacgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tgctatattt tcaaatgaac aacctgaaat tggaagacac ggccgtgtat
      421 tactgtgcga gagatgtcta tggcagggga cttgactact ggggcctggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001270             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16884:15536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001270
VERSION     KCXD01001270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16884:15536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59752.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          112 a          115 c          147 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcaatcac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa attctacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccctgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01001271             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11630:8065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001271
VERSION     KCXD01001271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11630:8065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59753.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       432..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          141 c          152 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtaa
      181 aggtctcctg ccaggtttcc ggatacacct tcagtgaaat gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgttgc tcctggaaat ggtgaaataa
      301 tacacgcaga gaacttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtagc ctgagatctg aggacacggc cgtgtattac tgtgcgacag
      421 ggaggttcgg gagcagcgtc tggtccagcc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001272             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22397:11177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001272
VERSION     KCXD01001272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22397:11177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59754.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          140 c          136 g           98 t
ORIGIN      
        1 acatgggggg atcacacaac aaccacatcc ctcccctaca ggagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cggcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggttaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga atttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001273             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23424:7189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001273
VERSION     KCXD01001273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23424:7189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59755.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          111 c          153 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtta
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001274             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15975:11590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001274
VERSION     KCXD01001274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15975:11590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..493
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59756.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       433..440
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          119 a          140 c          142 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt cgtggcagca gctacaggcg cccactctga
      121 ggtccagttg gtgcagtctg gggctgaagt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgtaaagtt tccggataca cggtcatcga tttatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgaa catggtgaag taatatacgc
      301 agacaacttc cagggcagag tcgccatgag cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtgtat tactgtgcga cccacggagg
      421 atatagaggc atctggaact ccctatacta cggtttcgat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tccccagcc
//
LOCUS       KCXD01001275             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6322:6540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001275
VERSION     KCXD01001275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6322:6540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59757.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          118 c          152 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccatt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catgcactgg gtccgccagg ctccagggaa gggtctggag tgggtggcag ttatgtcgca
      301 tgatggaact aagaaattct acgcagactc tgtgaaggac cgattcacca tctccaggga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg agattggagg acgcggccgt
      421 gtattactgt gcgagaggag actacggtaa cagccttgac tactggggcc agggagtcct
      481 gctcaccgtc tcctcagcc
//
LOCUS       KCXD01001276             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14547:5554
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001276
VERSION     KCXD01001276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14547:5554"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59758.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagctctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 agactaagaa atactacgca gactctgtga agggccgatt caccatctcc agagacaatt
      361 ccaaaaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001277             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:6357:4818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001277
VERSION     KCXD01001277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:6357:4818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..460
     V_segment       106..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59759.1"
                     /translation="CASPLLPATGNW"
     D_segment       417..424
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           86 a          143 c          128 g          105 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcatg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg tgatgtctct
      181 ggctactcca tcaatagtgg ttactcctgg ggctggctcc gtcagccccc agggaaggca
      241 ctggagtggg ttggctttat cggtggtcgt agtgggagca ccaactacaa cccctccctc
      301 aggagtcgag tctccatttc aaaagacacg tccaagagcc agttctccct gatcctgacc
      361 tctctgaccg ccgcggacac ggccgtttat tactgtgcga gtcctctcct tccggcaact
      421 ggaaactggg gccagggaat cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001278             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15895:4766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001278
VERSION     KCXD01001278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15895:4766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59760.1"
                     /translation="CATSYNNFWSGYLPDYW"
     D_segment       423..441
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          143 c          129 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccga ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcagg gtttccggat ccaccttcac cgatttatcc ttccactggg tgcgacaggc
      241 ccctggaaaa ggacttgagt ggatgggata tgttaaccct gtgcaagatg aattaataca
      301 cgcagacaac ttccagggca gagtcacctt gaccgaggac acgtctaccg acacagccta
      361 catggagctg agcagcctca gatctgagga cacggccgta tattactgtg cgacctcata
      421 taacaatttt tggagtggtt acttacctga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001279             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15456:17210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001279
VERSION     KCXD01001279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15456:17210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..479
     V_segment       119..411
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59761.1"
                     /translation="CARVRGWYLGYFDYW"
     D_segment       417..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           97 a          144 c          139 g          101 t
ORIGIN      
        1 acatgggcaa cgcagagtac atgggggttc tctgagagtc acggacatcc tgtgcaagaa
       61 catgaagcac ctgtggttct tcctcctcct ggtggcagct cccagatggg tcctgtccca
      121 gctgcagctg caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcac
      181 ctgcactgtc tctggtggct ccatcaacaa taactactgg acctggatcc gccagccccc
      241 agggaaggga ctggagtgga ttggacgtat cgctggaact ggtgggagca ccgactacaa
      301 tccctccctc aagagtcgag tcaccatttc aacagacacg tccaagaacc agttctccct
      361 gaagctgaac tctgtgaccg ccgcggacac ggccgtgtat tactgtgcga gggtgcgcgg
      421 ctggtacttg ggctactttg actattgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01001280             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:6857:15651
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001280
VERSION     KCXD01001280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:6857:15651"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59762.1"
                     /translation="CARARYYHDSGYHWYFDIW"
     D_segment       421..440
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          120 a          144 c          128 g          103 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tgatgcagtc cggggctgag gtgaagaagc ttggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcaac atctatgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttcagtg gatgggagga atcatccctc ttgttgatct aacaaactac
      301 gcacaagaat tccagggcag agtcacgatt accgcggaca cgtccacaac cactgcctac
      361 atggagctga gcagcctgag atctgaggac acggccatat attactgtgc gagagcgcga
      421 tattaccatg atagtggtta ccactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01001281             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14995:18847
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001281
VERSION     KCXD01001281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14995:18847"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59763.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       407..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           96 a          138 c          138 g          107 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gaggctctgt cagcagtagc acctggtgga actggatccg ccagccccca gggaaaggac
      241 tggaatggat tggctatatc agtggtgata gtggtaggaa ctcctacaac ccctccctca
      301 agagtcgaat caccatttca acagacacgt ccaagaacca gttctccctg aggctggggt
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag aggttcctat agtggcagtt
      421 attacttcaa ccggttcgat gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001282             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19770:2170
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001282
VERSION     KCXD01001282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19770:2170"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..493
     V_segment       142..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59764.1"
                     /translation="CANALTGGLDYW"
     D_segment       440..448
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          106 a          121 c          159 g          109 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 accactgaac acagaggact caccatggag tctgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taggtactgg
      241 atgaactggg tccgccaggc tccaggaaag gggctggagt gggtctcagc tattgcaagt
      301 ggtggagaaa acacatacta tgcagactcc gtgaagggcc gattcaccgt ctccagagac
      361 aactcaaaga gcacagtctc cctgcaaatg aacagtctta gaacggagga cacggccgtg
      421 tattactgtg cgaatgcgtt aactgggggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001283             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20346:14147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001283
VERSION     KCXD01001283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20346:14147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..493
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59765.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       437..445
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          115 a          111 c          155 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt tactatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atgtcgaatg
      301 atggaaataa gaaatactac ggagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa caggctatat cttcaaatga acaacctgaa attggaggac acggcagtgt
      421 attactgtgc gagagatgat agtggggtga tcatcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctccgcc
//
LOCUS       KCXD01001284             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:11191:9457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001284
VERSION     KCXD01001284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:11191:9457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59766.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       244..255
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       257..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           79 a           67 c           84 g           68 t
ORIGIN      
        1 acatggggca gcttctggat tcaccttcag tagttatggc atgcactggg tccgcctggc
       61 tccggggaag gggctggagt gggtggcagt tacatcgtct gatgaaagta agaaatacta
      121 cggagactct gtgaaggacc gattcaccat ctccagagac aattccaaga acatactata
      181 tcttcaaatg aacaacctga aattgaagga cacggccgta tactactgtg ggagagatga
      241 taatggggtg attatcgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001285             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17753:11762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001285
VERSION     KCXD01001285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17753:11762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59767.1"
                     /translation="CTRDVYGSGFDYW"
     D_segment       446..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          110 c          154 g          128 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctggaggag gcttggttca
      181 gcctcggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aggatatatt acgcagactc tgtgaagggc cgattcatca tctccagaga
      361 caattccaag aacatggtct atcttcaaat gaacaacctg aaatttgacg acacggccgt
      421 gtattattgt accagagatg tgtacggtag tgggtttgac tactggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001286             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11807:8493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001286
VERSION     KCXD01001286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11807:8493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59768.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       438..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          129 c          148 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctggctt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgaa atgggtctca tctattagta
      301 gtggtggtct cacatactac gcagactccg tgaagggccg atttgccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag cgctgaggac acggccgtat
      421 attattgtgc gaaaggaggt agcagttctt tctattggta tttcgatatc tggggccctg
      481 gcaccccagt gaccatctcc tcagcc
//
LOCUS       KCXD01001287             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17086:6851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001287
VERSION     KCXD01001287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17086:6851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    132..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        132..486
     V_segment       132..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59769.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       428..433
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          108 a          112 c          152 g          116 t
ORIGIN      
        1 acatgggggg agcccagccc tggaagtcca cagtgttcca ttcggtgatc agcacagaac
       61 acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct attttaagag
      121 gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag ccgggggggt
      181 ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttttggc atgcactggg
      241 tccgccaggc tccagggaag gggctggagt gggtggcagt tacatcgtct gatgaaacta
      301 agaaatacta cgcagactct gtgaaggccc gattcaccgt ctccaaagac aattccaaga
      361 acatgttata tcttcaaatg gacaacctga aattggaaga cacggccgtg tattactgcg
      421 cgagagatgt ctgggggagg ggatttgact attggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01001288             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22515:15903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001288
VERSION     KCXD01001288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22515:15903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59770.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          134 c          136 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggctat atatatggga gtgatagtag caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaaggtga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001289             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:25206:15272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001289
VERSION     KCXD01001289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:25206:15272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..489
     V_segment       120..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59771.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       427..442
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          112 a          141 c          139 g           99 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aagtccagct ggtgcagtct ggggctgaag tgaggaggcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggagac accttcaccg aattatccgt gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg gtgggaggtg ttcatcctct atatggtaaa ataacacacg
      301 cagagaactt ccaggacaga gtcatcatga ccgaggacac gtcgacagac acagcctaca
      361 tggagctgag cagcctgaca tctgaggaca cggccgtcta ttactgtgcg agaggatttt
      421 gtcatggtac ttattgctcc tcgggtcttg tctcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001290             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8568:22792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001290
VERSION     KCXD01001290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8568:22792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..513
     V_segment       138..431
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59772.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       452..459
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..513
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          101 a          128 c          158 g          128 t
ORIGIN      
        1 acatggggct ctgagacagg agccttagcc ctggattcca agaacttcca ctttgggatc
       61 agctctgaac acagaggacc atggagttgg ggctgagctg ggttttcctt gctgcttttt
      121 taaaaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggggccttg gtccagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac ctttggtgat tgtggcatgc
      241 actgggtccg ccaggctccg ggaaagggac tggagtgggt ctcatctatt agtaagactg
      301 gtgaaaccga atactacact gactccgtga agggccgatt cgccatttcc agaaacaacg
      361 ccaagaactc gctgtctctg gaaatgagca gcctgagagc cgaggacacg gccgtgtatt
      421 actgcactag aatttgttgt ccccgtgatt ttagcagcga ctgtcactgg ttcgatgtct
      481 ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001291             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17280:13964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001291
VERSION     KCXD01001291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17280:13964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59773.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          111 c          149 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtcca ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001292             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22510:13989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001292
VERSION     KCXD01001292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22510:13989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59774.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          110 c          159 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
      241 gcatgcactg ggtccgccag gctccaggga aggggctggg gtgggtggca gtgatatcgt
      301 ttgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001293             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6266:14364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001293
VERSION     KCXD01001293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6266:14364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59775.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          146 c          133 g          107 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgctctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctggagt ggaacagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01001294             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20868:4764
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001294
VERSION     KCXD01001294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20868:4764"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..489
     V_segment       117..407
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59776.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       416..430
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          143 c          139 g          102 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg aaggtctcct
      181 gcaagctttc cggatccacc ttcaccgaat tatccataca ctgggtgcga caggcccctg
      241 gaaaggggct tgaatggatg ggaggtgttg ctcctcttta tggtgaaatg atgcacgcag
      301 acaacttcca gggcagagtc accttgaccg aggacccgtc tacagacaca gcctacatgg
      361 agctgagcag cctgacatct gacgacacgg ccgtgtatta ctgtgcgcgt gggcctatta
      421 caatttttgg cgtacttatt acggggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001295             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14352:17079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001295
VERSION     KCXD01001295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14352:17079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59777.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          111 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc catttggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtcg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggct gttatatcgt
      301 atgatgaaaa taacagatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa taatatgata tatcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001296             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8155:10214
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001296
VERSION     KCXD01001296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8155:10214"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59778.1"
                     /translation="CATSSSGTWLYWYFDLW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          122 a          144 c          133 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgccga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagt ctgagatccg aggacacggc cgtatattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatctctg gggccctggc tccccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01001297             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18978:6193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001297
VERSION     KCXD01001297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18978:6193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..511
     V_segment       142..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59779.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       438..459
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..511
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          120 c          159 g          118 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccaggcc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttggtctga cctgggtttt ccttgttggt
      121 attttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagc cttggctcag
      181 cctggggggt ccctgagact ctcctgtgca gcgtctgggt tcaccttcag tagctatgcc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagc catatcattt
      301 gatggaagta agaaaaacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aactccaaca acatgctata tcttcaaatg aacaacctga aattggagga cacggccgta
      421 tactactgtt cgagggagtg gatacagtgg gcacagttag tgagcggttt ggattcctgg
      481 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001298             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15073:6217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001298
VERSION     KCXD01001298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15073:6217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59780.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       408..419
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          104 a          106 c          141 g          116 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccattgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc cctgagactc tcctgtgcag
      181 cctctggatt caccttcagt aactatggca tgcactgggt ccgccaggct ccagggaagg
      241 gtctggagtg ggtggcagtt atgtcgcatg atggaactaa gaaattctac gcagactctg
      301 tgaaggaccg attcaccatc tccagggaca attccaagaa catggtatat cttcaaatga
      361 acaacctgag attggaggac gcggccgtct attattgtgc gagaggagac tatggtaaca
      421 gccttgactt ctggggccag ggagtcctgc tcaccgtctc ctcagtc
//
LOCUS       KCXD01001299             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:11648:10726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001299
VERSION     KCXD01001299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:11648:10726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..506
     V_segment       128..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59781.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       434..446
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..506
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          115 a          139 c          154 g          100 t
ORIGIN      
        1 acatggggga gagcatcaca caacaaccac atccctcccc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc
      121 ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 aaaggtctcc tgccaggttt ccggatacac cttcagtgag atgtccatgc actgggtgcg
      241 acaggcccct ggaaaagggc ttgagtggat gggatgtgtt gctcctggaa atggtgaaat
      301 aatacacgca gagaacttcc aggacggagt caccatgacc gaggacacgt ctatagacat
      361 agcctacatg gagctgagta gcctgagatc tgaggacacg gccgtgtatt actgtgcgac
      421 agggaggttc gggagcagcg tctggtccag cctcttctac ggtttggatt cctggggcca
      481 aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001300             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15616:18625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001300
VERSION     KCXD01001300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15616:18625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59782.1"
                     /translation="CARICNGIYCGRYGLDSW"
     D_segment       406..414
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          137 c          137 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatggagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtgg
      181 ctccatcagt actagcaact attggagctg gatccgccag tccccaggca aggggctgga
      241 atggattggg ggcacctatg gtaatggtgg gagtaccgaa tacaacccct ccttcaagag
      301 tcgaatcagt gtttcaaaag acacgtccaa gaaccagttc tccctgaagc tgaactctgt
      361 gaccgccgcg gacaccgccg tctattactg tgcgagaatc tgtaatggta tttattgcgg
      421 gcgctacggt ttggattcct ggggccaagg ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01001301             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:2567:15893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001301
VERSION     KCXD01001301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:2567:15893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59783.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       417..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           98 a          132 c          129 g          110 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctactggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agctttcgga ggccctgtcc ctcacttgcg ctgtctctgg
      181 tgactccatc agcagaagct actggaactg gatccgccag tccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaagatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001302             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17963:17796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001302
VERSION     KCXD01001302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17963:17796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59784.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       353..363
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       369..410
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           90 a           89 c          126 g          107 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagttggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagaaactt tggcatgcac tgggtccgcc aggccccagg
      181 gaaggggctg gattgggtgg cagttatgtc gtttgatgaa aatgtgaaat tctacgcaga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatgg tatatcttca
      301 aatgaacaac ctgaaattgg aggacacggc cctgtattac tgtgcgagag gggaatacag
      361 taattctatt gacttctggg gccagggagt cctggtcacc gtctcgtcag cc
//
LOCUS       KCXD01001303             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16035:15493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001303
VERSION     KCXD01001303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16035:15493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59785.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT           97 a          124 c          159 g          125 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcaact ggtggagtct gggggcggcc tggcttggcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agtttcagtt actactacat
      241 gagttgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      301 tgggggtagc acattctatg cagactccgt ggagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtctc ttcacatgga cggcctgaga cctgaggact cggctgttta
      421 ttactgtgcg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001304             303 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:9411:19225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001304
VERSION     KCXD01001304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 303)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 303)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:9411:19225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..301
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..301
     V_segment       8..236
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>270
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59786.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       242..247
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       253..301
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        302..>303
                     /gene="IGHG"
BASE COUNT           77 a           71 c           81 g           74 t
ORIGIN      
        1 acatggggtg cagcctctgg attcaccttc agtagttata gcatgcactg ggtccgccag
       61 gctccaggga aggggctgga gtgggtggca gttatatcgt acgatgaaac taagaaatac
      121 tatgtagact ctctgaagga ccgattcacc atctccagag acaattccaa gaacatgctt
      181 tatcttcaaa tcaacaacct gaaattggag gacacggccg tttattactg tgcgaggagg
      241 ccctggagtg cagatgcttt tgatttctgg ggccaaggac tcagggtcac cgtctcttca
      301 gcc
//
LOCUS       KCXD01001305             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8663:3513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001305
VERSION     KCXD01001305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8663:3513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59787.1"
                     /translation="CAGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          124 c          153 g          107 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaaatgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcagctctt aattatgatg
      301 gggatagtac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgcaca gcctgagaga ggatgacacg gccgtatatt
      421 tctgtgcggg cggggcgtac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001306             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22195:20466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001306
VERSION     KCXD01001306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22195:20466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59788.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       401..415
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          136 c          133 g          106 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggcga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggttact actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tatattagta ttagtgggag gaccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagttga cctctgtgac
      361 cgtcgcggac acggccgtgt attactgtgc gagatatcca tatagtggga gctacttcag
      421 gtactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001307             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8005:16890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001307
VERSION     KCXD01001307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8005:16890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..485
     V_segment       125..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59789.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          113 a          134 c          134 g          106 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggactt ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggcgc agtctggggc tgacgtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacacctt caccgaatta tccctgcact gggtgcgaca
      241 gggccctgga aaaggacttg agtggatggg aggttttgct cctatatatg gtgaattaat
      301 ccatgaaagg ttccagggaa gagtcagttt gaccgaggac acgtctacag acacagccta
      361 tatggagctg agcagcctga gatctgagga cacggccgtg tattattgtg cggcagctga
      421 cagtggttac ccattttact acttcgatat ttggggccct ggcaccccaa tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001308             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12037:9593
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001308
VERSION     KCXD01001308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12037:9593"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59790.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          115 a          122 c          146 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gaactgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga gttcaccttc agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccaagaa ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001309             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24446:5323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001309
VERSION     KCXD01001309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24446:5323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59791.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          112 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001310             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:25251:14906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001310
VERSION     KCXD01001310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:25251:14906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..497
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59792.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       417..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          114 a          138 c          144 g          107 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccacctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacc ttcagcatct cttccatcag ttgggtgcga caggcccctg
      241 gacaagggct tgggtggata ggagggatca tccctcttgt tggtatgaca aactacgaac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacgaaaaca gtcttcatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtctacta ttgtgcgaca ggggtatatt
      421 accaggatga aaacggttac ttttatgtcg gcggtgactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01001311             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15936:16228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001311
VERSION     KCXD01001311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15936:16228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59793.1"
                     /translation="CARGRSGGVWPNSFDYW"
     D_segment       429..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          132 c          146 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggccccagga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgaaataat
      301 tgtcgcagag aatttccagg acagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagcc tggaatctga ggacacggcc gtgtattact gtgcgagagg
      421 gaggagtggt ggtgtctggc cgaactcctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001312             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22853:16266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001312
VERSION     KCXD01001312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22853:16266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59794.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       452..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          117 c          153 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatgttaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg actggggatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat gtccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatagtg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001313             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21494:11722
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001313
VERSION     KCXD01001313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21494:11722"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59795.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          144 c          135 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccatt
      121 ctgaggtcca gctggtgcaa tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tttatatggt gaaatgatac
      301 acacagaaca gttccagggc agagtcaccc tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtattactgt gcgagtggcc
      421 ctagcggcag ctggaacgac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001314             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6233:9149
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001314
VERSION     KCXD01001314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6233:9149"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59796.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          110 a          118 c          162 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cagtcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatatcgt
      301 atgatggagg taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgaacaacct gaacttggcg gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001315             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:8210:8450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001315
VERSION     KCXD01001315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:8210:8450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59797.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       441..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          122 a          143 c          143 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaactggt gcagtctggg gctgaaatga agaagcctgg ggcctcagtt
      181 agggtctcct gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata
      301 atacacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gccttcatgg aattgagcag cctgacatct gaggacacgg ccgtgtattt ctgtgcgaaa
      421 ggggggttcg gaaccagcgt ctggtccaat ctcttctacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001316             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20987:19288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001316
VERSION     KCXD01001316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20987:19288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59798.1"
                     /translation="CVRVHDYAMYYFDYW"
     D_segment       442..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          115 c          150 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tcttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgca
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctctagaga
      361 caattccaag aatataatat atcttcaaat gaataccctg aaattggagg acacggccgt
      421 gtattactgt gtgagagtcc atgactacgc catgtactac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001317             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17465:12392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001317
VERSION     KCXD01001317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17465:12392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59799.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          102 a          128 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtggggct aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag accacactgt atcttcacat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gttagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001318             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8935:16154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001318
VERSION     KCXD01001318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8935:16154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..511
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59800.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>517
                     /gene="IGHG"
BASE COUNT          111 a          132 c          157 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtagt aatagatatt acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacaccctg agacctgagg acacggccgt
      421 gtattactgt gcgtcgaacc tacgtggaaa cacctacact tactggcggt cctttgacta
      481 ctggggccag ggagtcctgg tcaccgtctc cgcagcc
//
LOCUS       KCXD01001319             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:11938:14029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001319
VERSION     KCXD01001319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:11938:14029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59801.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          145 c          134 g          107 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc caagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01001320             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23130:17521
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001320
VERSION     KCXD01001320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23130:17521"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59802.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          115 c          150 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagttggtgg aatctggggg aggattggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gcttcactat ctccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactttagta atacggagtt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001321             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:4775:12643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001321
VERSION     KCXD01001321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:4775:12643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    147..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        147..519
     V_segment       147..439
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59803.1"
                     /translation="CTSHYSGSYYLDYFDSW"
     D_segment       448..468
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..519
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          116 a          121 c          153 g          131 t
ORIGIN      
        1 acatgggggc agctctggga gaggagaccc agccttggga ttccagctgt ctccacttgg
       61 tgatcagcac tgaacacagg agactcgcca tggagtttgt actgagctgg gttttccttg
      121 ttgctatatt aaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg
      181 tccagcctgg cgggtccctg agactctcct gtgctgcctc tggatttagt ttcggagact
      241 ttgccatgag ttgggtccgc caggcttctg ggaaaggact ggagtgggtt ggctatatta
      301 gaagcgtaca taggaattac gcgacagaat acgccgcgtc ggtaaaaggc agatttacca
      361 tctccagaga tgattcaaag aacacgctat atttacaaat gagcagcctg aaaaccgagg
      421 acacggccgt ctatttctgc accagccact atagtggtag ttattactta gactactttg
      481 actcctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001322             554 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6829:19521
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001322
VERSION     KCXD01001322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 554)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 554)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6829:19521"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    183..552
                     /note="immunoglobulin heavy chain variable region"
     V_region        183..552
     V_segment       183..479
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <471..>521
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59804.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       490..504
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       511..552
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        553..>554
                     /gene="IGHG"
BASE COUNT          117 a          140 c          160 g          137 t
ORIGIN      
        1 acatggggtc cctctcctga tgaaaaccag cccagctctg actctgcagc tctaggagag
       61 gagcccagcc ctgggattcc caggtgtttt catttgtgat cagcactgaa cacagaagac
      121 tcatcatgga gtttggcctg agctgggttt tccttgttgc tattttaaaa ggtgtccagg
      181 gtgaggtgca gctggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
      241 tctcctgtgc agcctctgga ttcaccttca gtgactactg gatgtactgg gttcgccaga
      301 cacctgagca ggggctggag tggatctcag ctattgatag tgctggtact agtaccacat
      361 actatgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc aaaaacacac
      421 tgtatcttca gatggacagc ctgacaactg aggacacggc tgtctattac tgtgcgagag
      481 ttccgggcct agtggtattt actggttcgc ttgactactg gggccaggga gtcctggtca
      541 ccgtctcctc agcc
//
LOCUS       KCXD01001323             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:8221:2635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001323
VERSION     KCXD01001323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:8221:2635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..474
     V_segment       108..399
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59805.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       405..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           92 a          140 c          133 g          111 t
ORIGIN      
        1 acatgggggg ctgtctgaga gtcagggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca ggtcccagat gggtcctgtc ccagccgcag ctgcagttgc
      121 aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcgcc tgcgttgtct
      181 ctggtggctc catcagcgat tactcctgga gctggatccg ccagccccca gggaagggac
      241 tggagtggat tgggaatatt gatgttcatc ttgcgggccc caactacaac ccctccctca
      301 agagtcgagt cgccatttca aaagacacgt ccaagaatca gttctccctg aagctgagct
      361 ctgtgaccgc cgcggacacg gccgtatatt tctgtgcgaa acaatatagt ggtagttatt
      421 actattccca ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001324             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7305:8890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001324
VERSION     KCXD01001324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7305:8890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59806.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          112 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001325             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:6772:9662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001325
VERSION     KCXD01001325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:6772:9662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59807.1"
                     /translation="CASADSGYPPYFFDFW"
     D_segment       415..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           82 a          143 c          141 g          115 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agtaccaact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtgt ttctttggtg gtggtatctt tggtggtggt actgacaccc agtacagccc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagaaccaat tctccctgca
      361 actgacgtct gtgaccgccg cggacacggc cgtgtatttc tgtgcgagcg ctgatagtgg
      421 ttatcccccc tacttctttg acttctgggg ccagggagtc ccggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01001326             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4279:10293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001326
VERSION     KCXD01001326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4279:10293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..373
     V_segment       8..285
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <277..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59808.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       295..316
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       326..373
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           77 a          109 c          101 g           88 t
ORIGIN      
        1 acatgggcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcac atgcgctgtc
       61 tctggtggct ctatcagcag tactaaatgg tggagctgga tccgccagcc cccagggaaa
      121 gggctggagt ggattgggta tatcagtggt agtagtggta acacctacta caacccctcc
      181 ctcaagagtc gagtcaccat ttcaacggac acgtccaaca accagttctc cctgaagctg
      241 agctctgtga ccgccgcgga cacggccgtt tattattgtg cgagatccca atcctattgt
      301 agtgggcttt actgcttcgg ctactactac tttgactact ggggccaggg agtcctggtc
      361 accgtctcct cagcc
//
LOCUS       KCXD01001327             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11605:12394
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001327
VERSION     KCXD01001327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11605:12394"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59809.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          121 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtcagg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tggtgggact accacaaatt atgcagactc cgtgaggggc agcttcacca tctccagaga
      361 gaacgccaag aacagactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat cattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001328             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11548:15128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001328
VERSION     KCXD01001328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11548:15128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59810.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       440..444
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          113 c          157 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatatct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgtc agttatatcg
      301 tctgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcaa aaaacatggt ttatcttcaa atgaacaacc tgaagttgga ggacacggcc
      421 gtgtatttct gtgtgagaga tgccttcggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001329             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19519:18621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001329
VERSION     KCXD01001329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19519:18621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..475
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59811.1"
                     /translation="CAIGPSGNWIHWSFDVW"
     D_segment       410..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>479
                     /gene="IGHG"
BASE COUNT          105 a          147 c          134 g           93 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaactgtc catgcactgg gtgcgacagg
      241 cccctggaaa aggacttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgatgt
      301 tccagggcag agtcacaatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 gcagcctgac acctgacgac acggccgtct attactgtgc gattggccct agcggcaact
      421 ggatccactg gtccttcgat gtctggggcc ctggcacccc aatcaccatc tcctcggcc
//
LOCUS       KCXD01001330             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:22307:20942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001330
VERSION     KCXD01001330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:22307:20942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..271
     V_segment       4..201
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <193..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59812.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       205..212
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       227..271
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           61 a           77 c           74 g           61 t
ORIGIN      
        1 acatggggga actggatccg ccagccccca gggaagggac tggagtggat tgggtatatc
       61 tctggtgctt atgggagcac cagctacaac ccctccctca agagtcgagt caccatttca
      121 acagacacgt ccaagaacca gttttccctg aggctgagtt ctgtgaccgc cgcggacacc
      181 gccgtgtatt actgtgtgag atatgaggat gaatccatta actaccactt tgacttctgg
      241 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001331             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9658:3017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001331
VERSION     KCXD01001331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9658:3017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..426
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59813.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       464..470
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          110 a          122 c          162 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcttga caaagccggg
      181 ggggtccctg agactctcct gtgcagcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggggtgggtc tcacgaatcg gtcatgatgg
      301 tggtagcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagaatgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gaggacacag ccgtatatta
      421 ctgtgccaga gagcggtttg ggggaattgg ggtaattatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01001332             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10959:6186
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001332
VERSION     KCXD01001332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10959:6186"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..504
     V_segment       135..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59814.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       431..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          114 a          120 c          157 g          115 t
ORIGIN      
        1 acatggggag aggagcccag gcctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttggtc tgacctgggt tttccttgtt ggtcttttga
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agccttggct cagcctgggg
      181 ggtccctgag actctcctgt gcagcgtctg ggttcacctt cagtagctat gccatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agccatatca tttgatggaa
      301 gtaagaaaaa ctacgcagac tctgtgaagg accgattcac catctccaga gacaactcca
      361 agaacatgct atatcttcaa atgaacaacc tgaaactgga ggacacggcc gtgtactact
      421 gttcgaggga gtggatacag tgggcacagt tagtgagcgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001333             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23330:4625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001333
VERSION     KCXD01001333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23330:4625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59815.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       447..455
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          114 c          158 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc acacggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctggggc tctcctgtgc agcctctgga ttcaccttca gtcactatgg
      241 cgttcactgg gtccgccagg ctccagggaa ggggatggag tgggtggcag ttatatcgta
      301 tgatgaaaat aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaag accatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gtgagagatg tcagaggcgg tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001334             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:8448:8704
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001334
VERSION     KCXD01001334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:8448:8704"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59816.1"
                     /translation="CARVSGYSSLYFYTFESW"
     D_segment       404..412
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          135 c          138 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaggc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc agtagtaact ggtggagctg gatccgccag tccccaggga aggggctgga
      241 atggattggg ggtctctatg ggagtggtgg gaacaccgaa tacaacgcct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccacttc tccctgaagc tgaattctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagagtt tccggatata gcagcctata
      421 tttttatact ttcgaatcgt ggggccgagg ggtcgtcgtc atcgtctctt cagcc
//
LOCUS       KCXD01001335             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13107:9681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001335
VERSION     KCXD01001335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13107:9681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..296
     V_segment       1..210
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <203..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59817.1"
                     /translation="CASGGYEDDSGFYFPDFFDSW"
     D_segment       217..236
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       253..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           62 a           77 c           84 g           75 t
ORIGIN      
        1 ctttagtatc tctgccatca gttgggtgcg acaggcccct ggacagggac ttgagtggat
       61 gggagggatc atccctcttg ttggtataac aaattacgca cggaagttcc agggcagagt
      121 cacgattacc gcggacacgt ccacaaccac agcctacatg gatctgagca gcctgagatc
      181 tgaggacacg gccgtctatt attgtgcgag cggtggttac gaggatgatt ccggttttta
      241 ttttccagac ttctttgact cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001336             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7107:15941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001336
VERSION     KCXD01001336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7107:15941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59818.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          112 c          152 g          124 t
ORIGIN      
        1 acatgggggg gagaggagct cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt cctgtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctc
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgtctgatg
      301 gaagtaacat atactacgca gcctctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gttatatctt caaatgaaca acctgaaatt tgaggacacg gccgtctatt
      421 actgtgcgag agatgtgtac ggtagtgggt tagactactg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001337             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7136:17501
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001337
VERSION     KCXD01001337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7136:17501"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..459
     V_segment       93..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59819.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       398..410
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           90 a          142 c          124 g          105 t
ORIGIN      
        1 acatggggag agtcacggac atcctgtgca agaacatgaa gcacgtgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag tcgggcccag
      121 gactggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt ggctccatca
      181 acgattacca ctggagctgg atccgccagc cccctgggaa gggactggag tggattggac
      241 atatctctca tagtcgtgga agcaccgact acaacccctc cctcaagagt cgcgtcacca
      301 tttcaacaga catgtccaag aaccagttct ccctgaagct gagctctgtg acccccgcgg
      361 acacggccgt ctattactgt gcgagagatc aggattctta cgtttactat cgcttctttg
      421 acttctgggg ccagggagtc ctggtcgccg tctcctcagc c
//
LOCUS       KCXD01001338             429 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17648:8027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001338
VERSION     KCXD01001338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 429)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17648:8027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    61..427
                     /note="immunoglobulin heavy chain variable region"
     V_region        61..427
     V_segment       61..354
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>396
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59820.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       367..374
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       378..427
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        428..>429
                     /gene="IGHG"
BASE COUNT           82 a          140 c          113 g           94 t
ORIGIN      
        1 acatgggggt atctgtggtt cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc
       61 cagctgcacc tgcaggagtc gggcccagga ctggggaagc cttcagaaac cctgtccctc
      121 acctgcgctg tctctggtgg ctccatcagt cgtaactggt ggagttggat ccgccagccc
      181 ccagggaagg gactggagtg gattggacgt atctctggta gtcttggaag taccagctac
      241 aacccctccc tcaagagtcg agtcaccatt tcaacagaca cgtccaagaa ccagttctcc
      301 ctgaagctga cctctgtgac cgccgcggac acggccgtgt atttctgtgc gagacattca
      361 gaccccgcaa ctactagctg gtacttcgat ctctggggcc ccggcacccc aatcaccatc
      421 tcctcagcc
//
LOCUS       KCXD01001339             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18881:15487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001339
VERSION     KCXD01001339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18881:15487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..429
     V_segment       75..368
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59821.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       379..387
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           95 a           94 c          133 g          109 t
ORIGIN      
        1 acatgggagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gcgattttaa
       61 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagccggagg
      121 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat ggcatacact
      181 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg aatgatgaaa
      241 ctaagaaata ctacgcagac tctgtgaagg accgattcac catttccaga gacaattcca
      301 agaggatgct atttcttcaa atgaacaacc tgaaattgga ggacacggcc gtctattact
      361 gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01001340             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20463:10104
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001340
VERSION     KCXD01001340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20463:10104"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..461
     V_segment       83..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59822.1"
                     /translation="CARIPCRGIYCYETYYYDYW"
     D_segment       390..407
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT          105 a          145 c          106 g          107 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcac cttctctggg ttctcaatca cctcttctgg
      181 aacaggtttg gtctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccat
      241 ttactggaat gatagtaaat actacaccac atcgctgagg agccggctca ccatctccaa
      301 ggacacctcc aaaaaccagg tggttctaac aataaccaac atggaccctg tggacacagc
      361 cacatattac tgtgcacgga taccttgtcg tggtatttac tgctatgaaa cctactacta
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001341             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14866:8681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001341
VERSION     KCXD01001341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14866:8681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..327
     V_segment       8..257
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59823.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       261..268
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           71 a           97 c           87 g           74 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc agcagtagct
       61 actggaactg gatccgccag cccccaggga agggactgga gtggattggg tacatctctg
      121 gtgcttatgg gagcaccagc tacaacccct ccctcaagag tcgaatcacc atttcaacag
      181 acacgtccaa gaaccagttt tccctggggc tgagttctgt gaccgccgcg gacaccgccg
      241 tgtattactg tgtgagatat gaggatgaat ccattaatta ccactttgac tactggggcc
      301 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001342             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24625:11077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001342
VERSION     KCXD01001342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24625:11077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59824.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          124 c          147 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ccattttaag aggtgtccag tgtgaggtgc agctggtgga gtccggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatttcgc
      301 atgatgaaac tacgagattc tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001343             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11627:11790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001343
VERSION     KCXD01001343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11627:11790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59825.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          115 c          157 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga atacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaag tagcatatac tacgcagcct ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatctgcaaa tgagcaacct gaaatttgag gacacggccg
      421 tgtattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001344             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16718:6633
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001344
VERSION     KCXD01001344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16718:6633"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59826.1"
                     /translation="CATHGGYSDIWTSLYNGLDSW"
     D_segment       423..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          121 a          146 c          140 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagccaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aagttaagag gcctggggcc tcagtgatgg
      181 tctcctgcca ggtttccggg tacaccgtca ccgaaatatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgctcc tgaaaaaaat gaattaatac
      301 acgcagacaa gttccaggac agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtggcctt acatctgagg acacggccgt gtattactgt gcgacccacg
      421 gagggtatag cgacatctgg acctccctat ataacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001345             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19750:12482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001345
VERSION     KCXD01001345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19750:12482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59827.1"
                     /translation="CARRPFGSDAFDFW"
     D_segment       447..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          112 a          114 c          155 g          122 t
ORIGIN      
        1 acatggggag gtctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg atttatcttc agtcactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatgaaaa taagaaatac tacgcagact ctgtgaagga ccgcttcacc atctccagag
      361 acaattccaa gaacatgctg tatcttcaaa tgaacagcct gaagttggag gacacggcca
      421 tgtattactg tgcgagacga ccgttcggta gtgatgcttt tgatttctgg ggccaagggc
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01001346             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12241:9095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001346
VERSION     KCXD01001346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12241:9095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59828.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          115 a          112 c          156 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaaat aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 gtattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01001347             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17531:19862
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001347
VERSION     KCXD01001347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17531:19862"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..293
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..293
     V_segment       8..226
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59829.1"
                     /translation="CARVRGGIAGYFDSW"
     D_segment       235..245
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       248..293
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        294..>295
                     /gene="IGHG"
BASE COUNT           66 a           70 c           90 g           69 t
ORIGIN      
        1 acatgggggc ttccccttca gttacttctg gatatactgg gttcgccggg caccagggaa
       61 ggggctggag tgggtctcag ctattgataa tgatggtgct ggcacatact atgcagactc
      121 cgtgaagggc agattcacca tctccagaga gaacgccaag aatacactgt atcttcaaat
      181 gaacagcctg agagttgagg acacggctgt ctatttctgt gcgagagtca gggggggtat
      241 agcagggtac tttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001348             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11715:3529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001348
VERSION     KCXD01001348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11715:3529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59830.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          118 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcctca gcc
//
LOCUS       KCXD01001349             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7566:11497
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001349
VERSION     KCXD01001349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7566:11497"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..262
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <256..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59831.1"
                     /translation="CATDAFGSGIDYC"
     D_segment       273..278
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..325
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           75 a           77 c          101 g           74 t
ORIGIN      
        1 acatgggagc ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt
       61 gggtctggca tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcggtt
      121 atatcgagtg atgaaagtaa gagatactac ggagactctg tgaaggaccg attcagcatt
      181 tccagagaca actccaagaa catgctatat cttcaaatga acaacctgaa attggaggac
      241 acggccgtgt attactgtgc gacagatgcg tttggtagcg ggattgacta ctgtggccag
      301 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001350             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21853:4619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001350
VERSION     KCXD01001350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21853:4619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59832.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          155 g          116 t
ORIGIN      
        1 acatgggtgg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg cggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc tatggcatgc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt gacggttata tcgaatgatg
      301 gaagtaagaa atactacgcg gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acgtgaaatt ggaggacacg gccgtctatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001351             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19684:18446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001351
VERSION     KCXD01001351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19684:18446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..485
     V_segment       125..418
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59833.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       428..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          100 a          144 c          133 g          110 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gtgcttcctt ttctgtcctc
       61 caccacgatg gggtcaactg ccatcctcac cctcctactg gctgttctcc aaggagtctg
      121 tgccgaggtg cagctggtgc agtctggagc agaggtgaaa aggcccgggg agtctctgaa
      181 gatctcctgt aagacttctg gatacagctt taccagttac tggatcacct gggtgcgcca
      241 gatgcccggg aaaggcctgg agtggatggg ggcgattgat cctagtgatt ctgctaccaa
      301 atacagcccg tccttccaag gccaggtcac catttcagcc gacaagtcca tcaccaccgc
      361 ctacctagaa tggagcagcc tgaaggcctc ggacaccgcc acgtattttt gtgcgaaagg
      421 tcccggagtg attattaact actttgacta ctggggccag ggagccctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001352             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:26380:12079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001352
VERSION     KCXD01001352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:26380:12079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..481
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59834.1"
                     /translation="CARDAGVGATILYYYDFW"
     D_segment       414..422
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           96 a          137 c          139 g          111 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gtcatggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag
      121 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct ctcctgcact
      181 gtctctggtg gctccttcag tggttactac tggaactgga tccgccagcc cccagggaag
      241 gggctggagt ggattgggtt tatcggtggt ggtagtggga gcaccgaata caacccctcc
      301 ctcaaaagtc gagtcaccat ttcaagagac acgtccaaga atcaattctc cctgaggctg
      361 acctctatga ccgccgcgga cacggccgtt tatttctgtg ccagagatgc gggagtggga
      421 gccacaatcc tttactacta tgatttctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01001353             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21663:15091
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001353
VERSION     KCXD01001353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21663:15091"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59835.1"
                     /translation="CVRDRRVQSLSWFDAW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          102 a          124 c          158 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgctc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acgctggtgg
      301 ggatagcaca tactatgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aagtggacag cctgagagct gaggacacgg ctgtctattt
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgcctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001354             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22227:16055
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001354
VERSION     KCXD01001354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22227:16055"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59836.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       438..444
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          120 c          147 g          118 t
ORIGIN      
        1 atggggagct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcatcttcag taactatgcc
      241 atgcactggg tccgccaggc tccagggaag gggctagagt gggtggcagt tatttcgcat
      301 gatggaacta agaaatacta cacagactct gcgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatacaata tcttcacatg aacagcctga aattggagga cacggccata
      421 tactactgtg cggcctccta cttggggtac ggttttgagt actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001355             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12614:11803
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001355
VERSION     KCXD01001355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12614:11803"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59837.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       432..437
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          147 c          139 g           91 t
ORIGIN      
        1 atgggggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccgc
      121 tctgaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattct ccacgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgcatatgg tgaaatgaca
      301 cacgcagaaa acttccaggg cagactcacc atgaccgagg acacgtctac agacacggcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattattg tgcgagatca
      421 tccagcggta cgtggctata ctggtacttc gatacctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001356             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19925:5444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001356
VERSION     KCXD01001356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19925:5444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59838.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       407..415
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           93 a          137 c          138 g          108 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctctcctgc actgtctctg
      181 gtggctcctt cagtggttac tactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtttatcggt ggtggtagtg ggagcaccga atacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaga gacacgtcca aaaatcaatt ctccctgaag ctggcctcta
      361 tggccgccgc ggacacggcc gtttatttct gtgccagaga tgcgggagtg ggagccacaa
      421 tcctttacta ctatgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001357             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13461:18366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001357
VERSION     KCXD01001357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13461:18366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59839.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       430..445
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          141 c          141 g          100 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aagtgaggag gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga gacaccttca ccgaattatc cgtgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggag gtgttcatcc tctatatggt aaaataacac
      301 acgcagagaa cttccaggac agagtcatca tgaccgagga cacgtcgaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt ctattactgt gcgagaggat
      421 tttgtcatgg tacttattgc tcctcgggtc ttgtctcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001358             304 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14696:15860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001358
VERSION     KCXD01001358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 304)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 304)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14696:15860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..302
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..302
     V_segment       8..226
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>271
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59840.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       240..255
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       268..302
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        303..>304
                     /gene="IGHG"
BASE COUNT           70 a           79 c           88 g           67 t
ORIGIN      
        1 acatggggga gacaccttca ccgaattatc cgtgcactgg gtgcgacagg cccctggaaa
       61 agggcttgag tgggtgggag gtgttcatcc tctatatggt aaaataacac acgcagagaa
      121 cttccaggac agagtcatca tgaccgagga cacgtcgaca gacacagcct acatggagct
      181 gagcagcctg acatctgagg acacggccgt ctattactgt gcgagaggat tttgtcatgg
      241 tacttattgc tcctcgggtc ttgtctcctg gggccaggga gtcctggtca ccgtctcctc
      301 agcc
//
LOCUS       KCXD01001359             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10646:19948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001359
VERSION     KCXD01001359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10646:19948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59841.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          110 c          152 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaagacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctactt
      121 taagaggtgt ccagtgtgac gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atattacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccaagaatat gctatatctt caaatgaaca acctgaaact ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgttagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001360             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11595:21539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001360
VERSION     KCXD01001360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11595:21539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59842.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       416..424
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          139 c          144 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga agtgaggaag cctggggtct cagtaaaggt
      181 ctcctgcaag gtttccggaa acaccatcac cgaattatcc gtgcactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggggg tgttgatccc gtctatggtg aaataagaca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtc tattactgtg cgcgaggata
      421 ttgtcatggt agttactgtt cctcgggtct tgtctcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001361             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13253:20497
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001361
VERSION     KCXD01001361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13253:20497"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59843.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          116 c          149 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggag gagagatttg gctacagttt tgacttctgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001362             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:10480:10060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001362
VERSION     KCXD01001362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:10480:10060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59844.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          131 c          137 g          113 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc atatgcgctg tctctggagg
      181 ctctatcagc ggtggttatg actggagctg gatccgccag cccccaggga ggggactgga
      241 gtggattggg tatatctatg gtagtcgtgg gggcgccacc tacaacccgt ccctcaagaa
      301 tcgagtcacc atctcaaaag acacgtccaa gaaccagttg tccctgaagc tgaactctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagacag tgttgttact atgatgactt
      421 tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001363             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10663:15109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001363
VERSION     KCXD01001363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10663:15109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59845.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          138 c          127 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggacaggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tttattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001364             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17645:2419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001364
VERSION     KCXD01001364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17645:2419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59846.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          112 c          157 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagagtctcc tgtgcagcct ctggattcac cttcagtact agcggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggctgttgaa tcgcatgatg
      301 gaaataagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggatacg gccgtgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001365             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24635:14511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001365
VERSION     KCXD01001365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24635:14511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59847.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       407..422
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          135 c          130 g          108 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtggctccat caccaatagt tactggaact ggatccgcca gcccccagga aaggggctgg
      241 agtggattgg gtctatctat ggtggtactg ggagcaccgg ctacaatccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgaag ctgacctctg
      361 tgaccgccgc ggacaccgcc gtttattatt gtgcgagata tgaggatgaa tacagtgact
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001366             436 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24942:16657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001366
VERSION     KCXD01001366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24942:16657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..434
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..434
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>403
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59848.1"
                     /translation="CARGDSGIYYYFDSW"
     D_segment       382..391
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       392..434
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        435..>436
                     /gene="IGHG"
BASE COUNT           98 a           94 c          132 g          112 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtccag tgtgaggaac acctggtgga gtctggagga ggcttggttc agccgggggg
      121 gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtagtgatg tcatgcactg
      181 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc atgatggaag
      241 taagaagtat tatgtagact ctgtgaggga ccgattcgcc atctccagag acaattccaa
      301 gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg tgtattactg
      361 tgcgagagga gatagcggta tttattacta ctttgactcc tggggccagg gagtcctggt
      421 caccgtctcc tcagcc
//
LOCUS       KCXD01001367             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12368:7660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001367
VERSION     KCXD01001367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12368:7660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59849.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          113 c          158 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagtctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgacatcg
      301 tatgatggaa gttggaagta ctacggagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagagg ggaatacagt aactctgttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001368             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:7460:13390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001368
VERSION     KCXD01001368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:7460:13390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59850.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          119 a          140 c          134 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagagt tccatgccag attcaccatg accgaggaaa cgtctacaga cacagcctac
      361 atggagttga gcagcctaag atctgaggac acggccctgt attattgtgc agtcgggtat
      421 agcggccgat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01001369             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12094:17275
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001369
VERSION     KCXD01001369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12094:17275"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59851.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          113 a          116 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc atctggagga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg taacctctgg attcaccttc agtagctatg
      241 gcatgcactg ggcccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagatttac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagag gagaaatttg gctacagttt tgacttctgg ggccagggag
      481 tcctggtcac cgtctcctcg gcc
//
LOCUS       KCXD01001370             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19933:11867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001370
VERSION     KCXD01001370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19933:11867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..523
     V_segment       145..444
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59852.1"
                     /translation="CAREAYSWNNLYFYGLDSW"
     D_segment       451..465
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..523
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          114 a          126 c          163 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga agagaccccg cctgggattc ccaggagttt ccacctggtg
       61 atcagcactg aacacaaacc accagccatg gagtttgggc tgagctgggt tttccttgtt
      121 gctatttgga aaggtgtcca gtgtgaggtg cagctggtgg agtccggggg aggcttggtc
      181 cagcctggcg ggtccctgag cctctcctgt gcagcctctg gattcacctt cagtgattct
      241 ggtatggact gggtccgcca ggctccagga aaggggctgg agtgggtagg tttcattaga
      301 agcaaaactt atggtgggac agcagaatac tccgcgtctg tgaagggcag attcaccatc
      361 tccagagatg attcaaagaa cacggcgtat ctgcagatga ccagcctgaa aaccgaggac
      421 acggccgtat attactgtgc tagagaggcg tatagttgga acaacctata tttctacggt
      481 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001371             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15053:6224
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001371
VERSION     KCXD01001371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15053:6224"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59853.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       421..427
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          138 c          143 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggta cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggaatcacct tcaccgattt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tactgtatct gatggaatga
      301 tatacggaga aaacttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgcgaggg
      421 gtgtgacagc agacgtcttc ggtttcctcg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001372             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16889:19641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001372
VERSION     KCXD01001372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16889:19641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59854.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          116 c          149 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc tactggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgctt tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001373             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7876:6317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001373
VERSION     KCXD01001373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7876:6317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59855.1"
                     /translation="CARVRGWYLGYFDYW"
     D_segment       401..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>463
                     /gene="IGHG"
BASE COUNT           89 a          139 c          134 g          101 t
ORIGIN      
        1 acatgggggg gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctccatca acaataacta ctggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc gtatcgctgg tactggtggg agcaccgact acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag agccagttct ccctgaagct gaattctgtg
      361 accgccgcgg acacggccgt ctattactgt gcgagagtgc gcggctggta cttaggctac
      421 tttgactatt ggggccaggg agtcctggtc accgtctcct gcc
//
LOCUS       KCXD01001374             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9520:12715
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001374
VERSION     KCXD01001374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9520:12715"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..408
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..408
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59856.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       352..360
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       371..408
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        409..>412
                     /gene="IGHG"
BASE COUNT           91 a           89 c          133 g           99 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagttacta tggcatgcac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cagttatgtc gaatgatgga agtaagaaat actacggaga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacaggc tatatcttca
      301 aatgaacaac ctgaaattgg aggacacggc agtgtattac tgtgcgagag atgatagtgg
      361 ggtgatcatc gactactggg gccagggagt cctggtcacc gtcgcctccg cc
//
LOCUS       KCXD01001375             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20605:11254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001375
VERSION     KCXD01001375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20605:11254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..500
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59857.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       422..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          116 a          141 c          145 g          102 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaacc ctggtgcctc agtgaagctc
      181 tcctgcaagg gttctggatt ctccctcagc accgaggcca tcagttgggt gcgacaggcc
      241 cctggacaag gacctgactg gatgggaggg atcatccctc tcgtgggtgc aacaaactac
      301 gcacagaagt tccagggcag agtcaagttt accgcggaca cgtccataaa cacagcctac
      361 atggaactga gcggcctgag atctgaggac acggccgtgt attattgtgc gaaatccgtg
      421 aattacgagg aagataacgg ttactattta ccgacggggt ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01001376             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:3674:13509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001376
VERSION     KCXD01001376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:3674:13509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59858.1"
                     /translation="CARYEEGGTTFAYW"
     D_segment       409..413
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           91 a          139 c          133 g           99 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gaccggtgaa gccttcggag accctgtccc ttacctgcgc tgtctctggt
      181 gactccatca ccagtagata ctggggctgg atccgccagc ccccagggaa gggactggag
      241 tggattggat atatctatgg tggcagtggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaag aaccagtttt ccctgaagct gaagtctgtg
      361 accgccgcgg acaccgccgt atatttctgc gcgcgatatg aagagggcgg aaccaccttt
      421 gcctactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001377             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16279:19545
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001377
VERSION     KCXD01001377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16279:19545"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59859.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          134 c          136 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagg tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatac atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001378             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:3017:11592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001378
VERSION     KCXD01001378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:3017:11592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59860.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          113 c          158 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtatctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcag ttgaatcgtt
      301 tgatggaagt aagaaattct acgcagactc tgtgaaggac cgattcacca tatccagaga
      361 caattccaag aacatggtgt atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001379             385 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19737:15828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001379
VERSION     KCXD01001379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 385)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 385)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19737:15828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..383
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..383
     V_segment       20..312
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>352
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59861.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       319..328
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       339..383
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        384..>385
                     /gene="IGHG"
BASE COUNT           82 a           91 c          122 g           90 t
ORIGIN      
        1 acatgggggt gtccagtgtg aggtgcagtt ggtggagtct gggggaggct tggtccagcc
       61 tggagggtct ctgagactct cctgtgtagc ctctggattc agcttcagaa gttacgaaat
      121 gagttgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagtcacac
      181 tggtgaaacc atataccacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      241 cgccaagaat tcgctgtctc tgcaaatgag cagtctgaga gccgaggaca cggccgtgta
      301 ttactgtact agaaaccgga atactgtaat gattgggtgg ttcgatgtct ggggcccggg
      361 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001380             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:27450:8606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001380
VERSION     KCXD01001380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:27450:8606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59862.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          112 c          149 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaaac tatggcatgc
      241 actgggtccg ccaggcccca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa attctacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccttgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001381             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9352:6677
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001381
VERSION     KCXD01001381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9352:6677"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59863.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          125 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggtgat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt ttcttcaaat ggacagcctg agagctgacg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01001382             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10207:13359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001382
VERSION     KCXD01001382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10207:13359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..502
     V_segment       136..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59864.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       443..451
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          115 c          148 g          128 t
ORIGIN      
        1 acatggggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga gatcaggact
       61 gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt tgctatatta
      121 aaaggtgtcc agtgtgtgga gcagctggtg gaatctgggg gaggcttggt acagcctggg
      181 gcgtccctga gactctcctg tgcagcctct ggattcacct tcagtagctt tgacatgcac
      241 tgggttcgcc aggctccagg gaagggtctg gactgggtat caggtattaa cattggcggt
      301 gacacgtact acccagactc tgtgaagggt cgattcacta tgtccagaga caatgccaag
      361 aactccgtgt atcttcaaat gaacagcctg agagttgagg acactgctgt gtatttttgt
      421 gcaaggggga tagataacta ccactatagt gatacggact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001383             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7961:12054
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001383
VERSION     KCXD01001383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7961:12054"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59865.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          159 g          116 t
ORIGIN      
        1 acatggggag ctctgggaaa ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggttc agctggtgga gtctggagga ggcttgggtc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttaagtcgc
      301 atgatggaac taagaaatac tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatgcta tatcttgaaa tgaacagcct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001384             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22001:3843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001384
VERSION     KCXD01001384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22001:3843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59866.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          125 c          157 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcaacttc aattactact
      241 acatgaactg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaca
      301 gtggtgggga tagcacctac tatgcggact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaatacactg tatcttcaaa tggacagcct gaaaactgac gacacggctg
      421 tctattactg tgcgagagtg gtgggtggtg ccgcaggata cttcgacttc tggggccagg
      481 gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001385             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16433:10511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001385
VERSION     KCXD01001385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16433:10511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59867.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          142 c          137 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact gggcctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccaggtctcc ctgaaagtga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcatc gtctcctcag cc
//
LOCUS       KCXD01001386             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13134:7630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001386
VERSION     KCXD01001386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13134:7630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59868.1"
                     /translation="CATSSSGTWLYWYFDTW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tacctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001387             354 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21319:10750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001387
VERSION     KCXD01001387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 354)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 354)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21319:10750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..352
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..352
     V_segment       6..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <280..>321
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59869.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       293..298
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..352
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        353..>354
                     /gene="IGHG"
BASE COUNT           83 a           84 c          103 g           84 t
ORIGIN      
        1 atgggggtgg agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt
       61 gcagcctctg gattcacctt cagtaactat ggcatgcact gggtccgcca ggctccaggg
      121 aagggcctgg agtgggtggc agttatatcg tacgatgaaa ataagaaata ctacgcagac
      181 tctctgaagg accgattcac catctccaga gacaattcca agaacatgct ttatcttcaa
      241 atgaacaacc tgaaattgga ggacacggcc gtttattact gtgcgaggag gccctggagt
      301 gcagatgctt ttgatttctg gggccaagga ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01001388             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16574:7606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001388
VERSION     KCXD01001388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16574:7606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59870.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          146 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctggttt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacattg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgctaact ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001389             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:13237:17231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001389
VERSION     KCXD01001389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:13237:17231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59871.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          119 c          149 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaatt gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001390             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8948:7874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001390
VERSION     KCXD01001390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8948:7874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59872.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          140 c          153 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctgcaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatgggg ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 ggggttcggt agcagtgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01001391             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20550:4490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001391
VERSION     KCXD01001391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20550:4490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59873.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          134 c          151 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcga
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc aatacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctggg gtgggtctca ggtattagta
      301 gtggtggtac cacatactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgac aactgaggac acggccgtat
      421 attactgtgc gaagggaggt agcagctctt tctactggta cttcgatatc cggggccctg
      481 gcaccccagt caccatctcc tcagcc
//
LOCUS       KCXD01001392             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11144:19349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001392
VERSION     KCXD01001392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11144:19349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..494
     V_segment       137..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59874.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       435..440
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..494
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          111 a          121 c          149 g          115 t
ORIGIN      
        1 acatgggggg acaggagccc agccctggaa gaccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgaactgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcccc ttcagtagct atggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagtcattt cgtacgacga
      301 aactaagaaa tactacgcag actctctgga ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctttatcttc agatgaacaa cctgaaattg gaggacacgg ccgtttatta
      421 ctgtgcgcgg aggccctgga gtgcagatgc ctttgatttc tggggccaag gactcagggt
      481 caccgtctct tcagcc
//
LOCUS       KCXD01001393             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9152:11853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001393
VERSION     KCXD01001393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9152:11853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59875.1"
                     /translation="CARWSDEDDHGYYYLDSW"
     D_segment       402..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          138 c          135 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtggagc cttcggagac cctgtccctc acttgcgctg tctctggtgg
      181 ctccatcagc aattactact ggaactggat ccgccagccc ccaggaaagg ggctggagtg
      241 gattgggtat atctatggtg gtagtgggag cacaagctac aacccctccc tcaagagtcg
      301 agtctccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac accgccgttt attactgtgc gagatggagc gacgaggatg atcacggtta
      421 ctattacctt gactcctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001394             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12097:11901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001394
VERSION     KCXD01001394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12097:11901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59876.1"
                     /translation="CAIGPTGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          144 c          135 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg acacaccttc accgaattgt ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgaag
      301 ttccaggcca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgtg tattactgtg cgattggccc taccggcagg
      421 tggaacgact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001395             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18360:19866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001395
VERSION     KCXD01001395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18360:19866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59877.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       445..451
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          119 c          151 g          119 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctgaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaatact acgccgactc tttgaaagac cgattcacca tatccagaga
      361 cgactccagg aacatgctat atcttcaact gaacaacctg aaattggacg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctg ggggcttgac tactggggcc agggagtcct
      481 agtcaccgtc tcctcagcc
//
LOCUS       KCXD01001396             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10734:6697
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001396
VERSION     KCXD01001396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10734:6697"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..509
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59878.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       455..462
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>513
                     /gene="IGHG"
BASE COUNT          103 a          130 c          159 g          121 t
ORIGIN      
        1 acatgggggc tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttggtga ttatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatccat taggaacact
      301 ggtaaaatcg tatactacgc tgactccgtg aagggccgat tcaccatttc cagagacaac
      361 gccaagaact cgctgtctct gcgaatgagc agcctgagag ccgaggacac ggccgtgtac
      421 tactgtacta gaattggcgt cggatctctg gcaacggctg gtgactactt tgaccactgg
      481 ggccagggag tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01001397             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:25356:12413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001397
VERSION     KCXD01001397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:25356:12413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59879.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       412..419
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          100 a          136 c          152 g          106 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctataga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacacgttc agcatctatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg tataacaaac tacgctcaga
      301 ggttccgggg cagagtcacg atttccgcgg acacgtccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagggga gattgtactg
      421 atactgactg ctcttccgcg gggggcgcct ttgatttctg gggccaaggg ctcagggtca
      481 ccgtctcttc agcc
//
LOCUS       KCXD01001398             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24385:20653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001398
VERSION     KCXD01001398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24385:20653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..491
     V_segment       134..430
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59880.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       441..445
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          100 a          146 c          139 g          108 t
ORIGIN      
        1 acatggggcc ttaaattcag ggtccagctc atatgggaaa ggttctctga gagtcacgga
       61 catcctgtgc aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag
      121 atgggtcctg tcccaggtgc agctgcagga gtcgggccca ggactggtga agccttcgga
      181 gaccctgtcc ctcacctgcg ctgtctctgg tggcgccatc agcagtggtt tctactggac
      241 ctggatccgc caacccccag ggaaggggct ggagtggatt gggtgtatcg gtggtagtag
      301 tgggaccacc tactacaacc cctccctcaa gagtcgagcc accatttcaa aagacacgtc
      361 caagaatcaa ctctccctga agctgagttc tgtgaccgcc gcggacacgg ccgtgtatta
      421 ctgtgccaga gatgaagacc cctccatttt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001399             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16559:21090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001399
VERSION     KCXD01001399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16559:21090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..480
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59881.1"
                     /translation="CARRGYNNADDWYFDFW"
     D_segment       409..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          106 a          143 c          136 g           97 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgca gtccggggct gaggtgaagg agcctggggc ctcagtgaag ctctcctgcc
      181 aggcttctgg atacaccttc ggcatctacg ccatcaattg ggtgcgacag gtccctggac
      241 aagggcttga gtggatggga gggatcaccc ctcttattgg cttaacaaac tacgcacaga
      301 agttccaggg cagagtcacg ctcaccgcgg acacgtccac aagtacagtc tacatcgagt
      361 tgaacagcct gagatctgag gacacggccg tgtatttctg tgcgagacgt ggatacaaca
      421 acgctgacga ctggtacttc gatttctggg gccctggcac cccgatcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01001400             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23602:18193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001400
VERSION     KCXD01001400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23602:18193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59882.1"
                     /translation="CATADYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          113 a          123 c          148 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagccttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag tatgaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta catcttcaaa tgaacaacct gaaattggag gacactgccg
      421 tttattactg tgcgacagcc gactacggta acagccttga ctactggggc cagggagccc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01001401             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:17063:15624
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001401
VERSION     KCXD01001401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:17063:15624"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59883.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          120 c          149 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001402             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13163:8123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001402
VERSION     KCXD01001402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13163:8123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59884.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           92 a          138 c          131 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc aacaatcaac tctccctgaa ggtgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001403             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19925:11732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001403
VERSION     KCXD01001403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19925:11732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59885.1"
                     /translation="CTKDDVVVFSGPVDW"
     D_segment       457..463
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          118 c          152 g          128 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc aactggtgga gtctgggggc ggcttggcga
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtaactact
      241 ggatgtactg ggttcgccag gcacctggga aggggctgga gtgtatctcc ggtattaata
      301 ctgctggtgg tagcacgtac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacactcta tatcttcaaa tgaacagcct gagagctgag gacacggctg
      421 tctattactg tacgaaagat gacgttgtcg ttttttctgg tcccgtagac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001404             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:10996:7927
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001404
VERSION     KCXD01001404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:10996:7927"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..494
     V_segment       146..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59886.1"
                     /translation="CARADRGSSIDYW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagttgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtggggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaacctatg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga gtgggtggcg gttatatcat
      301 atgatgatga caagaaatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttttattg tgcgagagcg gatcgcggca gttcaattga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01001405             398 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20152:10188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001405
VERSION     KCXD01001405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 398)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 398)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20152:10188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..392
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..392
     V_segment       12..303
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <297..>365
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59887.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       312..336
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       352..392
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        393..>398
                     /gene="IGHG"
BASE COUNT           89 a          103 c          119 g           87 t
ORIGIN      
        1 acatggggtc ccaggtccac ctggtgcagt ccggggctga ggtgaagaag cctggggcct
       61 cagtgaagct ctcctgcaag gcttctggat acaccttcag catctcttcc atcagttggg
      121 tgcgacaggc ccctggacaa gggcttgggt ggataggagg gatcatccct cttgttggta
      181 tgacaaacta cgaacagaag ttccagggca gagtcacgat taccgcggac acgtccacga
      241 aaacagtctt catggaactg agcagcctga gatctgagga cacggccgtc tactattgtg
      301 cgacaggggt atattaccag gatgaaaacg gttactttta tgtcggcggt gactttgact
      361 actggggcca gggagtcctg gtcaccgtct ccccagcc
//
LOCUS       KCXD01001406             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16138:22708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001406
VERSION     KCXD01001406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16138:22708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59888.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          138 c          128 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggacaggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tttattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001407             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:15847:4697
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001407
VERSION     KCXD01001407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:15847:4697"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59889.1"
                     /translation="CARVTGIDESSVEYFEFW"
     D_segment       443..449
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..512
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          118 a          121 c          151 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagt ctccagggca ggggctggaa tgggtggcac ttatatcgta
      301 tgatggaact aagaaatact atgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagtaa ccggtataga tgaaagttcc gttgaatact tcgagttctg
      481 gggccagggc gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001408             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14099:2102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001408
VERSION     KCXD01001408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14099:2102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59890.1"
                     /translation="CARVDCSGGVCFFDYW"
     D_segment       438..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          112 a          112 c          153 g          126 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggaatctgg aggaggcctg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtggc tatggcatga
      241 actgggtccg ccaggctcca gggaagggac tggattgggt gtcaattata tcgtttgatg
      301 gaactaagaa atactacgca gactctgtga aggaccggtt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca gcctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agtggactgt agtggtggtg tctgcttttt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001409             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21943:10711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001409
VERSION     KCXD01001409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21943:10711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59891.1"
                     /translation="CARDEGDVSGYRFGYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          114 a          114 c          161 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg cgtctggagg aggcttggtt
      181 cagcctgggg ggtccctgaa actctcctgt gcagcctctg aattcacctt cagtagctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tttgatggaa gtaagaaata ctacgcagac tctatgaagg accgattcac catctctaga
      361 gacaattcca agaacatgct atatcttcaa gtgaacaacc tgagattgga ggacacggcc
      421 atgtattact gtgcgaggga tgagggggac gttagcgggt accgatttgg ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001410             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17499:17398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001410
VERSION     KCXD01001410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17499:17398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59892.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          117 c          149 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatag
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaact aagaaatact acgtagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat caacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01001411             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10007:11128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001411
VERSION     KCXD01001411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10007:11128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59893.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       440..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          125 c          158 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctgggggcg gcttggcgaa
      181 gcctggggga tccctgagac tcttctgtgc agcctctgga tttaccttca atacctattc
      241 tatacactgg gtccgccagg ctcccgggaa ggggctggag tgggtctcag ccattagtag
      301 tggtggtaga acatactacg cagactccgt gaagggccga gtcaccatct ccagagacaa
      361 ctcaaagaac acagtctccc tgcaaatgaa cagcctggga gctgaggaca cggccgtgtt
      421 ttactgtgcg agaggggaga cagcttcagt ttactacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001412             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22385:9779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001412
VERSION     KCXD01001412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22385:9779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59894.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       446..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          116 a          114 c          161 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgt
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcccgggggg tcactgagac tgtcctgtgc agcctctgga ttcaccttca gtagctctgg
      241 catgcactgg gtccgccagg ctccagggaa gggactggag tgggaggcac ttatatctaa
      301 tgatggaagt aagaaatatt acgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctgt atcttcaaat gaacaacctg aaattggatg acacggccgt
      421 gtattactgt gcgcgagttg gagagggtag tggtggtgcg gaggactttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001413             290 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15992:17684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001413
VERSION     KCXD01001413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 290)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 290)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15992:17684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..288
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..288
     V_segment       8..221
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <213..>257
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59895.1"
                     /translation="CARDSDSREFSFDYW"
     D_segment       236..240
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..288
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        289..>290
                     /gene="IGHG"
BASE COUNT           77 a           69 c           76 g           68 t
ORIGIN      
        1 acatgggcac cttcagtagc tatggcatac actgggtccg ccaggctcca gggaaggggc
       61 tggaatgggt ggcagttata tcgtttgatg gaagtaagac atactacgca gactctgtga
      121 atgaccgatt cagcatctcc agagacaatt ccaagaatat actatatctt caaatgaaca
      181 acctgaaatt ggaggacacg gccgtgtatt actgtgcgag agattccgac tcccgagaat
      241 tcagttttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001414             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:7441:10312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001414
VERSION     KCXD01001414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:7441:10312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59896.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           85 a          139 c          137 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 ctccttcagc ggttattcct ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gcttggatat atcagtggga gtagtgggag cgccgactac aagtcctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgttacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001415             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19442:18155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001415
VERSION     KCXD01001415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19442:18155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59897.1"
                     /translation="CATGRIGSSGWSNLFTGLESW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          146 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggatggga gttgttgatc ctgtcaatgg tgaagaaatt
      301 cacgcagaga aattccaggg cagagttacc ttgaccgagg acacgtccac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcggctg gtccaacctc ttcaccggtt tggaatcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001416             416 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23207:11538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001416
VERSION     KCXD01001416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 416)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 416)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23207:11538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    36..414
                     /note="immunoglobulin heavy chain variable region"
     V_region        36..414
     V_segment       36..327
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <321..>383
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59898.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       342..354
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..414
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        415..>416
                     /gene="IGHG"
BASE COUNT           90 a          106 c          135 g           85 t
ORIGIN      
        1 acatgggggt ggcagcagct acaggcgccc actctgaggt ccagctggtg cagtctgggg
       61 ctgaggtgaa gaagcctggg gcctcagtaa aggtctcctg ccaggtttcc ggatacacct
      121 tcagtgaaat gtccatgcac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg
      181 gatgtgttgc tcctggaaat ggtgaaataa tacacgcaga gaacttccag ggcagagtca
      241 ccatggccga ggacacgtct acagacacag cctacatgga gctgagtagc ctgagatctg
      301 acgacacggc cgtatattac tgtgcgacag ggaggttcgg gagcagcgtc tggtccagcc
      361 tcttctacgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001417             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17997:4232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001417
VERSION     KCXD01001417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17997:4232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59899.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       436..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          123 c          158 g          116 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaata taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggggata gcacatacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001418             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:1960:15752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001418
VERSION     KCXD01001418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:1960:15752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..271
     V_segment       12..208
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <202..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59900.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       219..224
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       230..271
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           68 a           60 c           86 g           59 t
ORIGIN      
        1 acatgggggt ctggcatgca ctgggtccgc caggctccag ggaaggggct ggagtgggtg
       61 gcggttatat cgagtgatga aagtaagaga tactacggag actctgtgaa ggaccgattc
      121 agcatttcca gagacaactc caagaacatg ctatatcttc aaatgaacaa cctgaaattg
      181 gaggacacgg ccgtgtatta ctgtgcgaca gatgcgtttg gtagcgggat tgactactgg
      241 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001419             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7501:20482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001419
VERSION     KCXD01001419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7501:20482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59901.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          125 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttaat ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggcgtggatc tcaggtatta acgctggtgg
      301 ggataccaca tactatgcag actccgtgaa gggcagatcc accatctcca gagagaacgc
      361 caggaacaca ctgcatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001420             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10389:14155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001420
VERSION     KCXD01001420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10389:14155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59902.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       410..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           90 a          136 c          129 g          112 t
ORIGIN      
        1 acaggggatg ctctctgaga gttatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca actcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcgg caatagctac tggatctgga tccgccagcc cccagggaag gggctggagt
      241 ggatagggtc tatctatggt agtactggga gcacctttta cgacccctcc ctcaagggtc
      301 gagtcaccgt ttcaacagac acgtccaaga acctattttc cctgactctg gactctgtga
      361 ccgccgcgga caccgccgtg tattactgtg cgagatatag cgatactgat agttattact
      421 tctttgacta ctggggccag ggagtccggg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001421             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:26388:4918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001421
VERSION     KCXD01001421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:26388:4918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..465
     V_segment       106..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59903.1"
                     /translation="CVRYEGAAAGTWYFDYW"
     D_segment       405..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>470
                     /gene="IGHG"
BASE COUNT           95 a          136 c          136 g          103 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaagtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgaccct cacctgcact gtctctggtg
      181 gctccatcag cagtagcttc tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattggata tatctatggt gctactggga ccaccagcta caatcccccc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaaggtg aactctgtga
      361 ccgccgcgga caccgccgta tattattgtg tgagatatga gggggcggca gctggaacct
      421 ggtactttga ctactggggc cagggagtcc aggtcaccgt ctccttagcc
//
LOCUS       KCXD01001422             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6311:15625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001422
VERSION     KCXD01001422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6311:15625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59904.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa ggctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtcttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001423             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22547:7271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001423
VERSION     KCXD01001423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22547:7271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59905.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          137 c          127 g          108 t
ORIGIN      
        1 acatggggaa gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctacaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatcg gcaatagcta ctggaactgg atccgccagc ccccagggaa gggtctggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001424             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21348:11959
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001424
VERSION     KCXD01001424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21348:11959"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59906.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       400..408
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          136 c          140 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctctggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatga gcagtcacta ctgcagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac ggatctctgg tagtggtggg agcaccgact acaaccccgc cctcaagagt
      301 cgagtcacca tctcaacaga cacgtccaag aaggagatct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagaag actatggtgg taattattat
      421 tttaaccggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001425             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22323:11271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001425
VERSION     KCXD01001425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22323:11271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59907.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          103 a          128 c          155 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaccagt
      301 ggtgggacta acacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga ccacactgta tcttcacatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg taagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001426             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14663:15828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001426
VERSION     KCXD01001426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14663:15828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59908.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       428..437
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          114 a          133 c          147 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gccccaggaa aagggcttga gtggatggga agtgttgatc ctgtatatgg tgaaataatt
      301 gtcgcagaga atttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct ggaatctgag gacacggccg tgtattactg tgcgaaaggg
      421 aggagtggtg gtgtctggcc gagctccttc gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001427             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:27710:9961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001427
VERSION     KCXD01001427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:27710:9961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59909.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          141 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc gtgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001428             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:10104:10967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001428
VERSION     KCXD01001428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:10104:10967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59910.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       439..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          112 c          155 g          115 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagtt ggtggagtct ggaggaggct tggttcagcc
      181 gggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta caagtggcat
      241 gcactgggtc cgccagactc cagggaaggg gctggagtgg gtggctgtta aatcgcacga
      301 tggaaataag aaatactatg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ctccaagaac atgctatatc ttcaaatgaa caacctgaaa ttggaggata cggccattta
      421 ttactgtgtg agagatgcct acgggggcgg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001429             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21986:18148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001429
VERSION     KCXD01001429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21986:18148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59911.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       441..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          116 a          113 c          156 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa ctaagaagta ctacggagac tctgtgaaag accgattcac catctccaga
      361 gacaattcca agaacaggct atatcttcaa atgaacaacc tgaaattgga ggacacggca
      421 gtatattact gtgcgagaga tgatagtggg gtgatcatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01001430             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4824:7041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001430
VERSION     KCXD01001430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4824:7041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59912.1"
                     /translation="CSRWGTPFDYW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           91 a          133 c          130 g          102 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcttgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 agctccatca acagtggtta tgcctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtgggttg ggcatatcta tgatagtagt ggaaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gttgaattct
      361 gtgaccgccg cggacacggc cgtgtattac tgttcgagat gggggacccc ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001431             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16996:10942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001431
VERSION     KCXD01001431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16996:10942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59913.1"
                     /translation="CAAQIHGSDWSGRFDVW"
     D_segment       425..431
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          119 a          130 c          144 g           99 t
ORIGIN      
        1 acatgggggg atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactgatgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atatgccttc acagaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggca ggtgttgatt ctgaatatgg tgaaataata
      301 gacgcagaga agttccagga cagagtcacc atgaccgagg acacgtctac agatacagcc
      361 tacatggagt tgagtaggct gaaatctgag gacacggccg tgtattactg tgcggcccaa
      421 attcatggta gcgactggtc tgggcggttc gatgtctggg gcccgggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001432             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17875:9179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001432
VERSION     KCXD01001432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17875:9179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59914.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       447..453
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          112 c          150 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctg
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggagac ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      301 atggaagtaa gacatactac gcaaactctg tgaaggaccg attcaccata ttaagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagacgat atgggaagtg gctttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001433             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17231:9891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001433
VERSION     KCXD01001433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17231:9891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59915.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       450..458
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          114 c          155 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ggttatatcg
      301 tttgatgata gtaagaaata ctacgtagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgtgagaga tgcttacggt agtggctggg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001434             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9513:5707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001434
VERSION     KCXD01001434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9513:5707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59916.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       434..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          102 a          112 c          150 g          123 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtcctgtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc ctcgggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt agttttggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atgtcgtctg atggaagtag
      301 catatactac gcagcctctg tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 catgttatat cttcaaatga acaacctgaa gtttgaggac acggccgtgt attactgtgc
      421 gagagatgtg tacggtagtg ggttagacta ctggggcctg ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001435             355 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20416:11732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001435
VERSION     KCXD01001435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 355)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 355)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20416:11732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..353
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..353
     V_segment       4..277
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>322
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59917.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       284..293
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..353
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        354..>355
                     /gene="IGHG"
BASE COUNT           85 a           88 c          100 g           82 t
ORIGIN      
        1 acatggggga ggcttggttc agccgggggg gtccctgaga ctctcctgtg cagcctctgg
       61 attcaccttc agtagctatg gcatgcactg ggtccgccag tctccagggg aggggctgga
      121 atgggtggcg cttatatcgt atgatggaac taagaaatac tacgcagact ctatgaagga
      181 ccgattcacc atctccagag acaattccaa gaacatgcta tatcttcaaa tgaacaacct
      241 gaaattggag gacacggccg tctattactg tgcgagagta agcggtataa ctgaaagttc
      301 cgttgaatac ttcgagttct ggggccaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01001436             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9406:12008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001436
VERSION     KCXD01001436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9406:12008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59918.1"
                     /translation="CARDSSWYNWDQDFDYW"
     D_segment       407..417
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           97 a          138 c          136 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcaagtgcgc tgtctctggt
      181 ggctccatca ccggtaacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtaccactga tagtggtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagata gtagttggta taactgggac
      421 caagactttg actactgggg cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001437             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17051:23758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001437
VERSION     KCXD01001437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17051:23758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59919.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       248..254
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           78 a           70 c           83 g           67 t
ORIGIN      
        1 acatggggca gcctctggat tcaccttcag taactatggc atacactggg tccgccaggc
       61 tccagggaag gggctggagt gggtggcagt tatatcgtct gatggaagta agacatacta
      121 cgcaaactct gtgaaggacc gattcaccat attaagagac aattccaaga gcatgctcta
      181 tcttcaaatg aacaacctga aattggagga cacggccgtc tattactgtg cgagagacga
      241 tatgggaagt ggctttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001438             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16747:4266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001438
VERSION     KCXD01001438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16747:4266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..496
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59920.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       418..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          115 a          140 c          145 g          100 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaaccctgg tgcctcagtg aagctctcct
      181 gcaagggttc tggattcacc ctcagcaccg aggccatcag ttgggtgcga caggcccctg
      241 gacaaggacc tgactggatg ggagggatca tccctctcgt gggtgcaaca aactacgcac
      301 agaagttcca gggcagagtc aagtttaccg cggacacgtc cataaacaca gcctacatgg
      361 aactgagcgg cctgagatct gaggacacgg ccgtgtatta ttgtgcgaaa tccgtgaatt
      421 acgaggaaga taacggttac tatttaccga cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01001439             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19874:19947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001439
VERSION     KCXD01001439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19874:19947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59921.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       441..451
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          110 a          129 c          149 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg agctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gtccagcctg
      181 gggggtccct gagactctcc tgtacagcca ctggattcac cttcagtagt tttggcatga
      241 gctgggtccg ccagcctcca gggaaggggc tggagtgggt ctcatacatt agtaatagtg
      301 gtagtagcac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgacagc tgaggacacg gccgtgtatc
      421 actgtgcgaa acatcgtttc agcagctggt cgtatttcct tgacttctgg ggccagggaa
      481 tcctggtcgc cgtctcctca gcc
//
LOCUS       KCXD01001440             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8717:17980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001440
VERSION     KCXD01001440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8717:17980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59922.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          137 c          145 g           98 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaag aaccagttct ccctgaggct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc ggcgggggtc
      421 gactactggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001441             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16846:2870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001441
VERSION     KCXD01001441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16846:2870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..510
     V_segment       135..428
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59923.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       449..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          101 a          126 c          157 g          128 t
ORIGIN      
        1 acatggggtg agacaggagc cttagccctg gattccaaga acttccactt tgggatcagc
       61 tctgaacaca gaggaccatg gagttggggc tgagctgggt tttccttgct gcttttttaa
      121 aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg ggccttggtc cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt tggtgattgt ggcatgcact
      241 gggtccgcca ggctccggga aagggactgg agttggtctc atctattagt aagactggtg
      301 aaaccgaata ctacactgac tccgtgaagg gccgattcgc catttccaga aacaacgcca
      361 agaactcgct gtctctggaa atgagcagcc tgagagccga ggacacggcc gtgtattact
      421 gcactagaat ttgttgtccc cgtgatttta gcagcgactg tcactggttc gatgtctggg
      481 gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001442             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18663:18802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001442
VERSION     KCXD01001442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18663:18802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59924.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       420..426
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          140 c          145 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctcc agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg gggtgttgat actgtatctg atggagtgat
      301 atacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgcgagagg
      421 tgtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001443             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21192:8134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001443
VERSION     KCXD01001443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21192:8134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59925.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       447..452
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          104 a          125 c          153 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagtt aatggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcagcta ttaacgctgg
      301 tggcgatacc acatactatg gagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgcatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 tttctgtgtg agagatcgac gtgttcagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc cctgtctcct cagcc
//
LOCUS       KCXD01001444             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9389:14698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001444
VERSION     KCXD01001444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9389:14698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59926.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          121 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtgaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtcagg ctccaggaaa ggggctggag tggatctcaa gtattgacaa
      301 tggtgggact accacaaatt ttgcagactc cgtgaggggc aggttcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat cattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001445             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13229:14358
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001445
VERSION     KCXD01001445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13229:14358"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59927.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       404..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           83 a          142 c          136 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agcatcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtccccagga aaggggctgg
      241 agtggattgg gtttttcggt ggttatggtg ggagcaccta ctacaacccc tccctccaga
      301 gtcgagtcac catttcagcc gacacgtcca aacaccagtt ctccctgata ctgacctctg
      361 tgaccgccgc ggacacggcc ctctactatt gtgcgagggg gaatatagca gcgactggca
      421 ttgactactg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001446             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15730:3848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001446
VERSION     KCXD01001446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15730:3848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59928.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          140 c          152 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctgcaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 ggggttcggt agcagtgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01001447             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:12099:19217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001447
VERSION     KCXD01001447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:12099:19217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..509
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59929.1"
                     /translation="CAKRGWAGSWNGGHYFDYW"
     D_segment       443..455
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>512
                     /gene="IGHG"
BASE COUNT          106 a          129 c          162 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gtccagcctg
      181 gggggtctct gagactctcc tgttcagcct ctggattcac tttcagtagc tattccatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcatacatt actaatggtg
      301 gtgttaccac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 cgatggacac gctctccctg caaatgaaca gcctgagagc tgaggacacg gccgtgtatt
      421 actgtgcgaa aagagggtgg gccggcagct ggaacggggg gcactacttt gactattggg
      481 gccagggagt cctggtcacc gtctcctcac cc
//
LOCUS       KCXD01001448             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12827:19967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001448
VERSION     KCXD01001448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12827:19967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59930.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       414..420
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           95 a          139 c          134 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtttctggt
      181 gactccatca acagtggcta ctactggagc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtatgtcgg tggtggtagt ggcatcacct actacaaatc atccctcaag
      301 agtcgagtca ccctctcaaa agacacgtcc aggaaccagt tctccctgaa actgagcgct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagaa aacttccagg tctgcaacta
      421 accggtttcg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001449             271 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7541:10647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001449
VERSION     KCXD01001449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 271)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 271)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7541:10647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..269
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..269
     V_segment       7..169
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <161..>238
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59931.1"
                     /translation="CAKDYVSYSDSGYYDLQVPYYGLDSW"
     D_segment       190..202
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       218..269
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        270..>271
                     /gene="IGHG"
BASE COUNT           61 a           72 c           75 g           63 t
ORIGIN      
        1 acatggggga ctggagtggg tctcaggtat tagtactggt ggaagcacat actccgccga
       61 ctccgtggcg ggccgattca ccatctccag agacaactca gagagcacac tctccctgca
      121 aatgaacagc ctgagagcgg aggacacggc cgtgtattac tgtgcgaaag attatgtctc
      181 ttactctgat agtggttatt acgacctgca agttccatac tacggtttgg attcctgggg
      241 ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001450             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15779:7464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001450
VERSION     KCXD01001450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15779:7464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59932.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       406..414
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          136 c          137 g          109 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc ttctacagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctctcttgca ctgtctctgg
      181 tggctccttc agtggttact actggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg tttatcggtg gtggtagtgg gagcaccgaa tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaagag acacgtccaa gaatcaattc tccctgaggc tgacgtctat
      361 gaccgccgcg gacacggccg tctatttctg tgcgagagat gcgggagtgg gagccacaat
      421 cctgtactac tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001451             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16370:4035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001451
VERSION     KCXD01001451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16370:4035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59933.1"
                     /translation="CTRDVYGSGFDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          110 c          154 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taggatatat tacgcagact ctgtgaaggg ccgattcatc atctccagag
      361 acaattccaa gaacatggtc tatcttcaaa tgaacaacct gaaatttgac gacacggccg
      421 tgtattattg taccagagat gtgtacggta gtgggtttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001452             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6495:3963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001452
VERSION     KCXD01001452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6495:3963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59934.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       429..444
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          141 c          140 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaagtccag ctggtgcagt ctggggctga agtgaggagg cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc gtgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggagg tgttcatcct ctatatggta aaataacaca
      301 cgcagagaac ttccaggaca gagtcatcat gaccgaggac acgtcgacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtc tattactgtg cgagaggatt
      421 ttgtcatggt acttattgct cctcgggtct tgtctcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001453             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:18039:9119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001453
VERSION     KCXD01001453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:18039:9119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59935.1"
                     /translation="CTRCHSNYDFW"
     D_segment       408..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           91 a          129 c          130 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gccccaggga agggactgga
      241 gtggattggg actatctatg gtaatagtgg taacatctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccc tatatttctg tacgagatgt catagtaatt acgacttctg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001454             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13582:12979
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001454
VERSION     KCXD01001454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13582:12979"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..457
     V_segment       100..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59936.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       399..408
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           83 a          136 c          137 g          103 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtgtttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagtcac cagggaaggg gctggagtgg
      241 attgggtttt tcggtggtag tggtgggaac acctactaca agtcgtccct ccagagtcga
      301 gtcaccattt caaccgacac gtccaagaac cagttctccc tgacactgac ctctgtgacc
      361 gccgcggaca cggccctcta ttactgtgcg agggggaata tagcagcgac tggcattgat
      421 tactggggcc agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001455             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13660:4535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001455
VERSION     KCXD01001455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13660:4535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59937.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          149 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001456             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16271:7713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001456
VERSION     KCXD01001456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16271:7713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59938.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          114 c          150 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcatacgatg
      301 aaaataagaa atactacgca gactctctga gggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01001457             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15816:5628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001457
VERSION     KCXD01001457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15816:5628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59939.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       445..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          123 c          146 g          119 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttcctttgg
      241 catgcactgg gtccgccagg caccggggaa ggggctggag tgggtggcag ttttatcgtc
      301 tgatggaact aacaaatact acgcagactc tttgaaagac cgattcacca tatccagaga
      361 caactccaag aacatactat atcttcaact gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctc ggggcttgac tactggggcc agggagtcct
      481 gctcaccgtc tcctcagcc
//
LOCUS       KCXD01001458             373 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13014:17221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001458
VERSION     KCXD01001458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 373)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 373)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13014:17221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    17..371
                     /note="immunoglobulin heavy chain variable region"
     V_region        17..371
     V_segment       17..310
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <302..>340
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59940.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       311..316
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       326..371
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        372..>373
                     /gene="IGHG"
BASE COUNT           90 a          101 c          107 g           75 t
ORIGIN      
        1 acatggggcc cactccgagg tccagctggt acagtctggg gctgaggtga agaagcctgg
       61 ggcctccgtg aaaatctcct gccaggcttc tggatacacc ttaaccgacc actacctgca
      121 ctgggtgcga caggctcctg gaaaaggact tgagtggatg ggaggtgttc atcctgaata
      181 tgggaaagta gactacacac agaagttcca agacagagtc accatcaccg cggacatgtc
      241 gacagagaca gtctacatgg agctgagcag cctgagatct gaggacacgg ccacttatta
      301 ctgtgtgaca gtgggtccct accattactt tgactactgg ggccagggag ccctggtcac
      361 cgtctcctca gcc
//
LOCUS       KCXD01001459             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11185:16346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001459
VERSION     KCXD01001459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11185:16346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59941.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          114 c          148 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 caacctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacatt gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa gtaacaaata ctacgctaac tctgtgaaga gccgattcac catctccaga
      361 gacaattcca agaacatact atatcttcaa atgaacaact tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatattggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001460             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5815:10220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001460
VERSION     KCXD01001460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5815:10220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..486
     V_segment       111..407
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59942.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       422..429
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT           90 a          140 c          145 g          113 t
ORIGIN      
        1 acatgggaca tgggaaatgt tctctgagag tcacggacat cctgtgtaag aacatgaagc
       61 acctgtggtt cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc
      121 tgcaggagtc gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg
      181 tctctggtgc ctccatcagc ggtggttatg gctggagctg gatccgccag gccccaggga
      241 agggactgga gtggattggt tttatctatg gtactggtgg tagcacctac tacacaccct
      301 ccctcaagag tcgactcacc atttcagcgg acacgtccaa gaaccagttc tccctgcatc
      361 tgacctctgt aaccgccgcg gacacggccg tgtattactg tgcgagagtt tcgggcaggt
      421 gggaactatt tgagcctggg tctgaggact tctggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01001461             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19550:3560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001461
VERSION     KCXD01001461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19550:3560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59943.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..445
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          121 c          147 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgctgctatt
      121 ttaagaggtg tccagtgtga ggtccacctg gtggaatctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttc ctttggcatg
      241 cactgggtcc gccaggcacc ggggaagggg ctggagtggg tggcagttat atcgtctgat
      301 ggaactaaca aatactacgc agactctttg aaagaccgat tcaccatatc cagagacaac
      361 tccaagaaca tactatatct tcaactgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga gagatgtgta tggctcgggg cttgactact ggggccaggg agtcctgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001462             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:25790:17701
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001462
VERSION     KCXD01001462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:25790:17701"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59944.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          114 c          154 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtcgctattt
      121 taagaggtgt ccagtgtgag gttcatctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagtct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtgaca tcgtatgatg
      301 gaagttggag gtactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagagcct gctctatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001463             291 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15578:3355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001463
VERSION     KCXD01001463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 291)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15578:3355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..289
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..289
     V_segment       7..224
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>258
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59945.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       230..235
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       241..289
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        290..>291
                     /gene="IGHG"
BASE COUNT           74 a           69 c           81 g           67 t
ORIGIN      
        1 acatggggat tcaccttcag tagctatggc atgcactggg tccgccaggc tccagggaag
       61 gggctggagt gggtggcagt tatatcgtac gatgaagaca agagatacta cgcagactct
      121 ctgaaggacc gattcaccat ctccagagac aattccaaga acatgcttta tcttcaaatg
      181 aacaacctga aattggagga cacggccgtt tattactgtg cgaggaggcc ctggagtgca
      241 gatgcttttg atttctgggg ccaaggactc agggtcaccg tctcttcagc c
//
LOCUS       KCXD01001464             303 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21223:10330
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001464
VERSION     KCXD01001464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 303)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 303)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21223:10330"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..301
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..301
     V_segment       7..222
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <214..>270
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59946.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       229..246
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..301
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        302..>303
                     /gene="IGHG"
BASE COUNT           68 a           86 c           84 g           65 t
ORIGIN      
        1 acatggggct ccttcagcgg ttactactgg agctggatcc gccagccccc agggaagggg
       61 ctggagtgga ttggatatat cagtgctagt agtgggacca ccgactacaa cccctccctc
      121 aagagtcgag tcaccatttc aagagacacg tccaagaacc tcttctccct gaacctgagc
      181 tctgtgaccg ccgcggacac ggccgtgtat tactgtgcga gagagaaata ctatagtggt
      241 agttataaac acaactggtt cgatgtctgg ggcccgggag tcctggtcgc cgtctcctca
      301 gcc
//
LOCUS       KCXD01001465             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11870:16162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001465
VERSION     KCXD01001465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11870:16162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59947.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          115 c          158 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaaggc ccgattcacc gtctccagag
      361 acaattccaa gaacatgtta tatcttcaaa cggacaacct gaaattggaa gacacggccg
      421 tgtattactg cgcgagagat gtctggggga ggggatttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001466             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24677:5496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001466
VERSION     KCXD01001466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24677:5496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59948.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          143 c          136 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactgc aggcgcccgc
      121 tctgaggtcc agctggtgca atctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gccccaggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacggagaaa aattccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggagc tgatcagtct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca cctggctatt ttggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001467             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22750:7353
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001467
VERSION     KCXD01001467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22750:7353"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..496
     V_segment       145..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59949.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       446..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          113 c          153 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgagtgcag ctggtggagt ctggaggagg cttggttcag
      181 ccggaggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tttctatggc
      241 atacactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatttcgaat
      301 gatgaaacta agaaatacta cgcagactct gtgaaggacc gattcaccat ttccagagac
      361 aattccaaga ggatgctatt tcttcaaatg aacaacctga aattggagga cacggccgtc
      421 tattactgtg tgagagatga tttaggcagc ggcttagggt cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001468             325 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:2470:15397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001468
VERSION     KCXD01001468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 325)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 325)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:2470:15397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..323
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..323
     V_segment       8..249
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <242..>292
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59950.1"
                     /translation="CASGRSGGVWPFSFDFW"
     D_segment       261..270
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..323
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        324..>325
                     /gene="IGHG"
BASE COUNT           71 a           83 c          104 g           67 t
ORIGIN      
        1 acatggggtg aaggtctcct gcaaggtttc cggacacagc gtcaccgaat tatccatgca
       61 ctgggtgcga caggcccctg gaaaagggct tgagtggatg ggaggtgttg accctgtata
      121 tggcgaggaa atacatgcag agaacttcca gggcagagtc accatgaccg aggacacgtc
      181 tacagacaca gcctacatgg agctgactag cctgcaatct gaggacacgg ccgtgtacta
      241 ctgtgcgagc gggaggagtg gtggtgtctg gccgttctcc tttgacttct ggggccaggg
      301 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001469             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13858:11036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001469
VERSION     KCXD01001469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13858:11036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..450
     V_segment       96..387
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59951.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       398..406
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT          103 a          101 c          141 g          107 t
ORIGIN      
        1 acatgggggt gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg
       61 ttttccttgt tgctatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag
      121 gagacttggt tcagccgggg tggtccctga gactctcctg tgcggcctct ggattcacct
      181 tcagaaccta tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
      241 cggttatatc gaatgatgaa actaacaaat actacggaga ctctgtgaag ggccgattca
      301 gcatctccag agacaattcg aagaacatgc tatatcttca aatgaacacc ctgaaattgg
      361 aggacacggc cgtgtattac tgtgcgacag atgcgtttgg tagtgggatt gaccactggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001470             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23624:19037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001470
VERSION     KCXD01001470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23624:19037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59952.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       436..447
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          115 c          152 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtttgctatt
      121 ttaagaggtg tccattgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactgtc ctgtgcagcc tctggattca ccttcattaa ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggt ctggagtggg tggcagttat gtcgcatgat
      301 ggaactaaga aattctacgc agactctgtg aaggaccgat tcaccatctc cagggacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgagat tggaggacgc ggccgtgtat
      421 tactgtgcga gaggagacta cggtaacagc cttgactact ggggccaggg agtcctgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001471             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16883:16536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001471
VERSION     KCXD01001471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16883:16536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59953.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          118 c          152 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtggc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttcg
      181 gcctgggggg tccctgagac tctcctgtgc agtctctgga ttcaccttca gtaattttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaatact atgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aacttggagg acacggccgt
      421 ctattactgt gcgagggacg catttggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001472             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21217:17065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001472
VERSION     KCXD01001472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21217:17065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59954.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       412..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          107 a          151 c          132 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcccgggg cctcagtgaa
      181 ggtctcctgc aaggtctccg gaaacacctt caccgaattg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cccgcatatg gtgaaatgac
      301 gttccagggc agagtcatca tgaccgagga cacgtctaca gacacagcct acatggagct
      361 gaccagcctg acatctgacg acacggccgt ctattactgt gcggttggcc ctagcggcac
      421 ttggaaccac tggcccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01001473             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14822:6987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001473
VERSION     KCXD01001473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14822:6987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59955.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       424..431
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          145 c          145 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagctcct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agtgcctggt ccaacctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001474             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18846:14872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001474
VERSION     KCXD01001474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18846:14872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59956.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       289..293
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           76 a           86 c          105 g           83 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctgggga gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agtacctctg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtgtct gtaatttcgt ctgatggaag taagaaatac tacgcagact
      181 ctgtgaagga ccgattcacc atctccagag acaactccaa gaacatacta tatcttcaaa
      241 tgaacaacct gaaattggag gacacggccg tgtatttctg tgtgagagat gccttcgggg
      301 gcggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001475             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18204:19813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001475
VERSION     KCXD01001475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18204:19813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59957.1"
                     /translation="CARDAGVGATILYYYDFW"
     D_segment       406..414
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          135 c          137 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctctcctgca gtgtctctgg
      181 tggctccttc agtggttact actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tttatcggcg gtggtagtgg gagcaccgaa tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaagag acacgtccaa gaatcaattc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tttattactg tgcgagagat gcgggagtgg gagccacaat
      421 cctttattac tatgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001476             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14004:13227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001476
VERSION     KCXD01001476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14004:13227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59958.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       420..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          110 a          143 c          145 g          105 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 ctcaagtcca gctggtgcag tccggggctg agatggagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacaccttca gcatctatgt catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag gcatcttccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga ttaccgcgga cacgtccaga agcacagcct
      361 acatggacct gagcagcctg ggatctgggg acacggccgt gtattactgt gcgagaggct
      421 actgcactgg tagtggttgt aaccttacat tcaaccggct cgatgtctgg ggcccgggag
      481 tcccggtcac cgtctcctca gcc
//
LOCUS       KCXD01001477             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14462:8735
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001477
VERSION     KCXD01001477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14462:8735"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..509
     V_segment       134..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59959.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       429..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..509
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          104 a          126 c          157 g          124 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tctgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcagcttt ggcgatcatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tctatcagta atactggtaa
      301 agccgtacac tacgctgact ccgtgaaggg ccgattcacc atctccagag acaacgccaa
      361 gaactcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg tgtattactg
      421 ttctagcgat tactatagtg gtagttatta ctattggggc tacggcttgg attcctgggg
      481 ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001478             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:17064:11226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001478
VERSION     KCXD01001478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:17064:11226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..460
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59960.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       406..412
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           97 a          134 c          129 g          102 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtccagct gcaggagtcg
      121 ggcccaggag tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagcg gttactactg gaactggatc cgccaaccac cagggaaggg gctggagtgg
      241 attgggtata tcgctggtag tagtgggagc atcgactaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac caattctccc tgaagctgaa ctctgtgacc
      361 gccgcggaca cggccatcta ttactgtgcg agaaataggt ttatgggtat aagagttctt
      421 gcctactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001479             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18071:14338
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001479
VERSION     KCXD01001479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18071:14338"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59961.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       428..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          113 a          123 c          148 g          107 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcggccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacagtgtca ccgaattatc gcttcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgtaaaaggt gaagaaattc
      301 acggagagga gttccaggac agagtcacca tgaccgagga cccgtctaca gacacagcct
      361 acatggagtt gagcaacctg agatctgagg acacggccgt gtattattgt gcgagtgggt
      421 ttagtatctg gttattttat gacgttttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001480             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14633:8457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001480
VERSION     KCXD01001480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14633:8457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59962.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       437..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          113 c          150 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcagc ttcagtaact ctggcattca
      241 ctgggtccgc caggctccag gggaggggct ggagtgggtg gcagttatat cgtatgatga
      301 aactaagaca tactacgcag actctgtgaa ggaccgattc accatttcca gagacaattc
      361 caagaacatg gtacatcttc aaatgaacac cctgaatttg gaggacacgg ccgtatatta
      421 ctgtgtgaga gattcttacg gtagaggctt tgaccagtgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001481             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23742:7166
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001481
VERSION     KCXD01001481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23742:7166"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59963.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          121 a          139 c          139 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgtcagg cttctggata ttccctcact cactacttca tgcactgggt gagacaggcc
      241 cctggacagg gccttgagtg gataggactg atcacccatc acaatgatca taaagtctac
      301 gcacagaact tccagggcag agtcaccata actacggaca cgtccacgag cacagtgtcc
      361 atggagctga gcagcctgag atccgaagac acagccgtat actactgtgc gagagggggg
      421 gacatagaat attgtactgg tagtggttgt ggggagcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001482             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23504:8004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001482
VERSION     KCXD01001482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23504:8004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59964.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       436..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          122 c          145 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcccc ttcactacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct cgagtggctg acagttatat cgtttgatga
      301 aactaaggaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtgtatta
      421 ctgtgcgaga gattcttacg gccgaggctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001483             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22049:15700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001483
VERSION     KCXD01001483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22049:15700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59965.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       419..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          129 c          140 g          112 t
ORIGIN      
        1 acatggggga tcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagcta caggtgtcca
      121 gtcccaggtc cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtttcctgc aaggcttctg gatttacctt cgacaactat ggaatcaact gggtgcggca
      241 ggcccctgga caagggcttg agtggatggg cgtggtcatc ccccttgttg gtattattaa
      301 ttatgcagag aacttccagg gcagagtaac gattaacgcg gacacgtcca taaacacagc
      361 cttcatggaa ttcaggagcc tgagatctga cgacacggcc atttatttct gtgcgagaga
      421 atactgtaca actactgatt gcgccgggtt ctttgactac tggggccagg gagtcatggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001484             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23103:19116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001484
VERSION     KCXD01001484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23103:19116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59966.1"
                     /translation="CARDCSGIYCAVYGLDSW"
     D_segment       399..414
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           83 a          130 c          146 g          116 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagt acctgtggtt
       61 cttcctcctc ctggtggcag ctcccggatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga gtggtgaggc cttcggagac cctgtcgctc acctgcgctg tctctggtgg
      181 ctccgtcaac agttactacc tctggagctg ggtccgccag tccccaggga agggactgga
      241 gtggattggg tatatctatg gtggtggtgg gaggaccagc tacaacccct ccctcgagag
      301 tcgagtcatc atttcaagag acacgtccaa caaccagttc tccctgaagt tgacctctgt
      361 gaccgccgcg gacacggcca tgtatttctg tgcgagggat tgtagtggta tttattgcgc
      421 tgtatacggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001485             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:10639:3949
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001485
VERSION     KCXD01001485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:10639:3949"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59967.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       406..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           92 a          135 c          137 g          112 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcagaga ccctgtccct cacctgcgct gtctctggag
      181 gctctctcag cggtggttat gactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg ctatatctat ggtggtactg ggagcaccac ctacaacccg tccctcagga
      301 atcgagtcac catttcaaaa gacacgtcca agaaccagtt gtccctgaag ctgagctctg
      361 tgaccgccgc ggacacggcc gtatattatt gtgcgagaca gtgctgttac tatgatgact
      421 ttttagacta ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001486             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23025:13296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001486
VERSION     KCXD01001486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23025:13296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59968.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          109 c          158 g          115 t
ORIGIN      
        1 acatgggggg gataggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccagggtcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaagtaggac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtgtatgtt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001487             435 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:26340:4925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001487
VERSION     KCXD01001487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 435)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:26340:4925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    67..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        67..433
     V_segment       67..356
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <349..>402
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59969.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       374..382
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..433
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>435
                     /gene="IGHG"
BASE COUNT           94 a           97 c          129 g          115 t
ORIGIN      
        1 acatgggcca tggagtttat gctgagctgg gttttccttg ttgctatatt aaaaggtgtc
       61 cagtgtgtgg agcagctggt ggaatctggg ggaggcttgg tacagcctgg ggcgtccctg
      121 agactctcct gtgcagcctc tggattcacc ttcagtagct ttgacatgca ctgggttcgc
      181 caggctccag ggaagggtct ggactgggta tcaggtatta acattggcgg tgacacgtac
      241 tacccagact ctgtgaaggg tcgattcact atgtccagag acaatgccaa gaactccgtg
      301 tatcttcaaa tgaacagcct gagagttgag gacactgctg tgtatttttg tgcaaggggg
      361 atagataact accactatag tgatacggac tttgactact ggggccaggg agtcctggtc
      421 accgtctcct cagcc
//
LOCUS       KCXD01001488             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14741:2983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001488
VERSION     KCXD01001488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14741:2983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59970.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       431..436
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          106 a          113 c          146 g          122 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttcctt tcggtgatca gcacagagca
       61 cagaggactc accatgaagt ttgggctgaa ctgggttttc cttgttacta ttttaagagg
      121 tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt atttttggca tccactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgaatg atggaagtaa
      301 aaaatactac tcagactctg tgaaggaccg attcaccatc tccagagaca actccgaggc
      361 cagtgtctat cttcaaatga ataacctgaa attggaggac acggccgtgt attactgtgt
      421 gagagatgcg tatggttccg gcttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001489             348 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12780:5169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001489
VERSION     KCXD01001489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 348)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 348)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12780:5169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..346
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..346
     V_segment       7..279
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>315
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59971.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       281..287
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..346
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        347..>348
                     /gene="IGHG"
BASE COUNT           70 a           91 c          112 g           75 t
ORIGIN      
        1 acatgggggg gcggcttggc aaagcctggg gggtccctga gactctcctg cgcagcctct
       61 ggtttcagct tcagtttcta ctatatgacc tgggtccgcc aggctccagg gaaggggctg
      121 gagtggattt caggtattga cactggaggg ggtgacacct actatgcaga ctccgtgaag
      181 ggcagattca ccatctccag agagaacgcc aagaagacac tgtatcttca aatggacagc
      241 ctgagagctg aggacacggc tgtctattac tgtgcgagag tagtgggtgg tgccgccgga
      301 tacttcgact tctggggcca gggcgccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001490             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20884:17559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001490
VERSION     KCXD01001490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20884:17559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59972.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          124 a          140 c          134 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctaaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001491             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13977:8627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001491
VERSION     KCXD01001491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13977:8627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59973.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       424..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          147 c          141 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagccac cggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagttaaga agcctggggc ctcagtgatg
      181 gtctcctgcc aggtttccgg atacaccgtc accgaaattt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgctc ctgaaaaaaa tgagttaata
      301 cacgcagaca agttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtggcct gacatctgag gacacggccg tgtattactg tgcgacccac
      421 ggagggtata gcgacatctg gaactcccta tatcacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001492             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18765:4572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001492
VERSION     KCXD01001492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18765:4572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59974.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       403..410
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          134 c          130 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 ggccccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtggcttct ggaactggat ccgccagacc ccagggaagg ggctggagtg
      241 gattgggtac atttatggta gtactgggaa caccggctat aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtcaaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac accgccgtgt attattgtgc gagatatgga gatgatagtg ttcattacaa
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001493             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21238:7964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001493
VERSION     KCXD01001493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21238:7964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59975.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          109 a          118 c          157 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagacact
      241 ggattaactg ggtccgccag cctccaggaa aggggcttga gtgggtctca actattaata
      301 gtggtgggga taacacatat tacgcggact ccgtgaaggg ccgattcacc atctccagag
      361 acaattcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattactg tgttcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001494             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15606:2165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001494
VERSION     KCXD01001494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15606:2165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59976.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       402..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..474
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           96 a          140 c          135 g          105 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccttcag cggttactac tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattggata tatcagtgct agtagtggga ccaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaagagac acgtccaaga acctcttctc cctgaacctg agctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagagaa atactatagt ggtagttata
      421 aacacaactg gttcgatgtc tggggcccgg gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01001495             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5521:21712
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001495
VERSION     KCXD01001495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5521:21712"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59977.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       431..436
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           94 a          148 c          133 g          114 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa accttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc atatcagtgg gagtagtggg ggcaccgact accacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag agccacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagc tttcccccta cgactatttt
      421 tggagtgatt tttactctta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01001496             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:23444:12533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001496
VERSION     KCXD01001496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:23444:12533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..478
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59978.1"
                     /translation="CARKFEYKKSLDVW"
     D_segment       421..427
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          114 a          131 c          134 g          101 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtgcaatc cggggctgag atgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggatt cccctttaac atctatgcca tcagttgggt gcgacaggcc
      241 cctggacaag gccttgagtg gatggggcgg atcatccctc ttggtgatat aacaaattac
      301 gctcagaagt ttcaggacag agtcacgatt accgcggaca cgtccacagg cacggcctac
      361 atggagctgc gaagcctgag atctgaggac acggccgtat attactgtgc gagaaaattc
      421 gaatacaaga agtcattgga tgtctggggc cggggagttc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001497             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16484:18660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001497
VERSION     KCXD01001497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16484:18660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59979.1"
                     /translation="CTRIGVGSLATTGQYFDYW"
     D_segment       457..463
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          111 a          123 c          153 g          127 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactggatc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagaaacac
      301 tggtaaaact atatattatg ctgactccgt gaagggccga ttcaccattt ccagagacaa
      361 cgccaagaac tcgttgtctc tgcaaatgga cagcctgaga gccgaggaca cggccgtgta
      421 ttattgtact agaattggcg tcggatctct agcaacgact ggtcagtact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001498             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19850:3994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001498
VERSION     KCXD01001498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19850:3994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59980.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       447..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          114 c          157 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cggaacctat
      241 ggcatgcact gggtccgcca ggctccaggg atgggcctgg agtgggtgac ggttatatcg
      301 aatgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcag catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacg tgaaattgga ggacacggcc
      421 gtttattact gtgtgagaga tgcgtttggt agcgggcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001499             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11408:5004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001499
VERSION     KCXD01001499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11408:5004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59981.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          108 c          156 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcatcttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaaat aagaaatatt acgcagactc tgtgaaggac cgattcacca tgtccagaga
      361 caattccagg aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttatttctgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001500             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14758:9097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001500
VERSION     KCXD01001500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14758:9097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59982.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       420..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          109 a          141 c          145 g          108 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 ctcaggtcca gctggtgcag tccggggctg agatggagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacaccttca gcatctatgt catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag gcatcttccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga ttaccgcgga cacgtccaca agcacagcct
      361 acatggacct gagcagcctg ggatctgggg acacggccgt gtattattgt gcgagaggtt
      421 actgtactgg tagtggttgt aaccttacat tcaaccggct cgatgtctgg ggcccgggag
      481 tcccggtcac cgtctcctca gcc
//
LOCUS       KCXD01001501             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18692:7366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001501
VERSION     KCXD01001501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18692:7366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59983.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          109 c          151 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gttcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcatatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001502             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17400:4212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001502
VERSION     KCXD01001502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17400:4212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59984.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       436..447
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          116 c          153 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccattgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggt ctggagtggg tggcagttat gtcgcatgat
      301 ggaactaaga aattctacgc agactctgtg aaggaccgat tcaccatctc cagggacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgagat tggaggacgc ggccgtctat
      421 tattgtgcga gaggagacta cggtaacagc cttgacttct ggggccaggg agtcctgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001503             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23664:9084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001503
VERSION     KCXD01001503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23664:9084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59985.1"
                     /translation="CARDRDTRSGYYGLDSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..506
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          115 a          119 c          155 g          119 t
ORIGIN      
        1 acatgggtct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggactc accttcagta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tatcgtatga
      301 tggaagtaag aaatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtata
      421 ttactgtgcg agagataggg atacacgcag cggctattac ggtttggatt cctggggccg
      481 aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001504             302 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:25984:4815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001504
VERSION     KCXD01001504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 302)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 302)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:25984:4815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..295
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..295
     V_segment       6..224
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <216..>269
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59986.1"
                     /translation="CAREYCTSDSCAGFLDSW"
     D_segment       225..236
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..295
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        296..>302
                     /gene="IGHG"
BASE COUNT           79 a           82 c           78 g           63 t
ORIGIN      
        1 acatgggatt cacccttgac aattatggaa tcaactgggt gcgacaggcc cctggacacg
       61 ggcttgagtg gatgggagtg atcatccccc ttgtcggaat agtaaactac gtagagaacc
      121 tccagggcag aggcacaata accgcggaca cgtcaacaaa cacagtctac atggaactga
      181 acagcctgag atctgacgac acggccatct attactgtgc aagagaatac tgtacttctg
      241 attcatgcgc cggattcctt gactcctggg gccagggagt cctggtcacc gtctctccag
      301 cc
//
LOCUS       KCXD01001505             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25927:5063
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001505
VERSION     KCXD01001505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25927:5063"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59987.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgacaga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcttc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cccggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001506             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:15510:4146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001506
VERSION     KCXD01001506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:15510:4146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59988.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       448..461
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          114 c          154 g          125 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccggtgt gagatacagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtttg
      301 atggaagtaa gaaatactac gcagactcta tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctagat cttcaaatga gcaacctgaa attggaggac acggccgtct
      421 attactgtgc gagaatggat tgtactggtg gtgtctgcta ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001507             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20792:10437
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001507
VERSION     KCXD01001507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20792:10437"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59989.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       420..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          147 c          137 g           94 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagca acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggcgttga tcctgcatat ggtgagttta
      301 cacccggaga gaagctccag ggcagagtca ccatgaccga agacacgtct atagacacag
      361 cctacatgga gctgagcagc ctgaattctg acgacacggc cgtctattac tgtgctgccg
      421 ggtatagcgg cagctggaac cactggtact tcgatctctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01001508             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15995:10592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001508
VERSION     KCXD01001508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15995:10592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59990.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       406..420
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          137 c          127 g          110 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gtgactctat cagcagtagt cactggtgga gctggatccg ccagccccca gggaaaggcc
      241 tggagtggat tggctatatc agtggtagtg gtgataacac ctactacaac ccctccctca
      301 agaatcgagt caccttttca acagtcacgt ccaagaacca gttctccctt aagctgagct
      361 ctgtgaccgc cgcggacacg gccatgtatt actgttcgag ggtgcgtgga tacaactaca
      421 ttttatttga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001509             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21622:10826
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001509
VERSION     KCXD01001509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21622:10826"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59991.1"
                     /translation="CAAQIHSGGWSGRFDVW"
     D_segment       429..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          135 c          146 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cctggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat atgccttcac agaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatggcagg tgttgattct gaatatggtg aaatgattga
      301 cgcggagacg ttccaggaca gagtcaccat gaccgacgac acgtctacag atacagccta
      361 catggagttg agtagcctga gacctgagga cacggccgtg tattactgtg cggcccaaat
      421 tcatagtggc ggctggtctg ggcggttcga tgtctggggc ccgggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001510             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21758:7324
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001510
VERSION     KCXD01001510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21758:7324"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59992.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          118 a          115 c          158 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtcactgaga ctctcctgtg cagcctctgg attcaccttc aataactctg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca cttatatctc
      301 atgatggaga taagaaatac tacgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctg tatcttcaaa tgaacaacct aaaattggat gacacggccg
      421 tgtattactg tgcgagagtt ggagagggta gtggtggtgc ggaggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001511             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14242:2319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001511
VERSION     KCXD01001511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14242:2319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59993.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       415..437
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           98 a          142 c          139 g          116 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtga tgtctctggt
      181 gcctccatca gtacttcctg gtggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg ttatagtggt agtttttact ccaccccctc cctcaacagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccagttcg ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt atattactgt gcgcgagatg ccgggtttgg ggaaacgata
      421 ttagtagtcg atattaatat gttcccccac tttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001512             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9430:19766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001512
VERSION     KCXD01001512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9430:19766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59994.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       453..467
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          116 a          126 c          147 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgacta
      241 tgccctgagc tgggtccgcc aggcttctgg gaaaggactg gagtggattg gctatattag
      301 aagccaatat aacaatttcg cgacagaata cgccccatcg gtgaaaggca gattcaccat
      361 ctccagagat gattcaaaga acacgctatt tctgcaaatg agtagcctga aaaccgagga
      421 cacggccgtg tattactgca ccacccattt tggtggtaat tattacttgg actactttgt
      481 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001513             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22786:12287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001513
VERSION     KCXD01001513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22786:12287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59995.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          126 c          155 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaga
      181 gcctgggggg tccctgagac tctcctgcac agcctctgga ttcaacttca aatactacta
      241 catgacctgg gtccgccagg ctccagggaa gggactggag tggatctcag gtattagcac
      301 tggtggggat aacacatacc aaggagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg aaagctgagg acacggctgt
      421 ctattactgt gcgagagttg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01001514             351 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:2998:15286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001514
VERSION     KCXD01001514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 351)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 351)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:2998:15286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..349
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..349
     V_segment       8..276
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <268..>318
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59996.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       289..296
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..349
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        350..>351
                     /gene="IGHG"
BASE COUNT           74 a          113 c           89 g           75 t
ORIGIN      
        1 acatgggcag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctggt
       61 ggctccatca gtcgtaactg gtggagttgg atccgccagc ccccagggaa gggactggag
      121 tggattggac gtatctctgg tagtcttgga agcaccagta acaacccctc cctcaagagt
      181 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gacctctgtg
      241 accgccgcgg acacggccgt gtatttctgt gcgagacatt cagaccccgc aactactagc
      301 tggtacttcg atctctgggg ccctggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01001515             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19134:10144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001515
VERSION     KCXD01001515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19134:10144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59997.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       427..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          140 c          138 g          104 t
ORIGIN      
        1 acatggggga ctcaacaact gcatccaacc tcaagagaag cccctgagag cacattttct
       61 caccatggac ttgacctgga agatcctcct cttggtgaca gcagccacag gtgcccactc
      121 ccaggtgcaa ctggtgcagt ctgggggtga gattaagcat cctggggcct cagtgaagct
      181 ctcctgtcag gcttctggat attccctcac tcactacttc atgcactggg tgagacaggc
      241 ccctggacag ggccttgagt ggataggact gatcacccct cacaatgatc ataaagtcta
      301 cgcacagaac ttccagggca gagtcaccat aactacggac acgtccacga gcacagtgtc
      361 catggagctg agcagcctga gatccgaaga cacagccgta tactactgtg cgagaggggg
      421 ggacatagaa tattgtactg gtagtggttg tggggagctt gactcctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001516             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23497:6952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001516
VERSION     KCXD01001516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23497:6952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..394
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59998.1"
                     /translation="CASLLNPSSDSW"
     D_segment       400..405
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           83 a          135 c          135 g          102 t
ORIGIN      
        1 acatggggag gtctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag tcttcggaga ccctgtccct cacctgcgct gtttctggtg
      181 gctccatcag gggttactgg tggggctgga tccggcagtc cccagggaag ggtctggagt
      241 ggattggcta tatcggtggc agtagtggga gcacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagatttc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tattcctgtg cgagtcttct aaacccttcg agtgactcct
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001517             530 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20559:14869
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001517
VERSION     KCXD01001517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 530)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 530)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20559:14869"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..528
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..528
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>497
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX59999.1"
                     /translation="CAKDYVSYSDSGYYDLQVPYYGLDSW"
     D_segment       449..461
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..528
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        529..>530
                     /gene="IGHG"
BASE COUNT          108 a          135 c          163 g          124 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tctgctatgc
      241 actgggtccg ccaggctcca gggaggggac tggagtgggt ctcaggtatt agtactggtg
      301 gaagcacata ctccgccgac tccgtggcgg gccgattcac catctccaga gacaactcag
      361 agagcacact ctccctgcaa atgaacagcc tgagagcgga ggacacggcc gtgtattact
      421 gtgcgaaaga ttatgtctct tactctgata gtggttatta cgacctgcaa gttccatact
      481 acggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001518             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17026:14564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001518
VERSION     KCXD01001518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17026:14564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60000.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       437..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          123 c          155 g          112 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacacacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccattgtgag gtgcagctgg tggaatctgg gggcggcttg gcaaagcctg
      181 gggggtccct aagactctcc tgtgcagcat ccggattcac cttcagtgac cactgcatgc
      241 actgggtccg ccaggcttca gggaaggggc tggagtgggt ctcaggtatt acttatgctg
      301 gtgttaccac atggtacgca gactccgtga ggggcagatt caccatatcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagacc tgaggacacg gctgtctatt
      421 actgtgtggg aggaaggcgg cacgtggacc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001519             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:26062:11998
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001519
VERSION     KCXD01001519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:26062:11998"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..465
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60001.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       412..417
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          106 a          132 c          139 g           90 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacagcttc aacatcgatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgtcgg tataacaaac tacgcacaga
      301 agttgcaggg cagagtctcg attaccgcgg acacggccac aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgatccaa gggaacagcc
      421 agtttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001520             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15694:13008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001520
VERSION     KCXD01001520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15694:13008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60002.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       443..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          116 c          155 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccactgt gaagtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag tctctgggtt caccttcagt ggctctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctgggatg ggtggcggtt atatcgaatg
      301 atggaactaa caaatactac gcagactctc tgaaggaccg atttagtatc tccagagaga
      361 attccaagaa catgctatat cttcaaatga acaacctgaa actggaggac acggccgtct
      421 attactgcgc gacagatgcg tttggtagcg ggattgacta ctggggccgg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001521             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:26386:16728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001521
VERSION     KCXD01001521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:26386:16728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60003.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          115 a          112 c          155 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaact aagaagtact acggagactc tgtgaaagac cgattcacca tttccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 atattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01001522             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20189:14174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001522
VERSION     KCXD01001522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20189:14174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60004.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       437..442
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          109 a          114 c          150 g          117 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agccgggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg gcatccactg
      241 ggtccgccag gctccgggga aggggctgga gtgggtgaca gttatatcgt atgatgaaac
      301 aaagaaattc tacgcaggct ctctgaagga ccgcttcatc atctccagag acaactccaa
      361 gaacatggta tatcttcaaa tgaatagcct gcaattggag gacacggcca tatattactg
      421 tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggtgtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001523             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13297:12842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001523
VERSION     KCXD01001523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13297:12842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60005.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          109 c          150 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tacagctggt ggagtctgga ggagacttgg ttcaccctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact ttggcataca
      241 ctgggtccgc cagggtccag ggaaggggct ggagtgggtg gcagttatat cgtatgatga
      301 aactaggaca tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattt
      361 caagaacatg atatttcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ttgtgtgaga gatgtcaggg gaacggggtt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01001524             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8232:20639
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001524
VERSION     KCXD01001524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8232:20639"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60006.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT           98 a          125 c          161 g          125 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcctggctt
      181 ggcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagtttc agttactact
      241 acatgagttg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaca
      301 gtggtggggg tagcacattc tatgcagact ccgtggaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tctcttcaca tggacggcct gagacctgag gactcggctg
      421 tttattactg tgcgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001525             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:3557:14984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001525
VERSION     KCXD01001525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:3557:14984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..489
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60007.1"
                     /translation="CAREYCTSDSCAGFLDSW"
     D_segment       419..426
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>496
                     /gene="IGHG"
BASE COUNT          117 a          140 c          138 g          101 t
ORIGIN      
        1 acatggggga tcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagcta caggtgtcca
      121 gtcccaggtc catttggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtttcctgc aaggcttctg gattcaccct cgacaactat ggaatcaact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg agtgatcatc ccccttgtcg gtatagtgaa
      301 ctacgtagag aacctccagg gcagaggcac gataaccgcg gacacgtcaa caaacacagt
      361 ctacatggaa ctgaacagcc tgagatctga cgacacggcc atctattact gtgcgagaga
      421 atactgcact tctgattctt gcgccggatt ccttgactcc tggggccagg gagtcccggt
      481 caccgtctct ccagcc
//
LOCUS       KCXD01001526             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13468:7962
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001526
VERSION     KCXD01001526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13468:7962"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60008.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          114 a          143 c          127 g           93 t
ORIGIN      
        1 acatgggatc acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttccggata caccttaacc gaccactacc tacactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt attcttcctg agtatggtaa agttgactac
      301 acacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga gacagtctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001527             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12080:7427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001527
VERSION     KCXD01001527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12080:7427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60009.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          137 c          139 g          101 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaggtaca ggcgcccact
      121 ctgaggtcca gctggtgcag tcgggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtttttggt gaaataatga
      301 attcagagaa gttccagggc agagtcgcct tgaccgagga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatat tggtacttcg atgtctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001528             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5616:22361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001528
VERSION     KCXD01001528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5616:22361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..489
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60010.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       431..441
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>496
                     /gene="IGHG"
BASE COUNT          113 a          139 c          142 g          102 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcctggtg gcggcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact ggctgcgaca
      241 ggcccctgga aaagggcttg agtggttggg atgtgttgat tataaatatg atgaagaaat
      301 atacgcagac aatttccagg gcagagtcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcggcggg
      421 ccttggggga tatttactgc ttactgaata tttccagttc tggggccagg gcgccctggt
      481 caccgtctct tccgcc
//
LOCUS       KCXD01001529             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:25448:9169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001529
VERSION     KCXD01001529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:25448:9169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60011.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          113 c          152 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 agaataagaa atactacgca gactctctga aggaccgatt caccatctct agagacaatt
      361 ccaagaacat gctttatctt gaaatgaaca acctgacatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01001530             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12106:16597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001530
VERSION     KCXD01001530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12106:16597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..468
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60012.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       408..417
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>471
                     /gene="IGHG"
BASE COUNT           95 a          140 c          128 g          108 t
ORIGIN      
        1 acatggggat ggtctctgag agtcatgggc ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccaataccta ctggaactgg atccgccagc ccccagggaa ggggctggaa
      241 tggattggat ttatctatgg tgctactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tctcaacaga cacgtccaag aaccaatttt ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg atcagtggga tgattacctg
      421 tactactttg actactgggg ccagggagtc ctggtcaccg tctcctcatc c
//
LOCUS       KCXD01001531             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19834:4752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001531
VERSION     KCXD01001531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19834:4752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..266
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <260..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60013.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       277..289
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..341
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           77 a           95 c          106 g           65 t
ORIGIN      
        1 acatgggggg gctgaggtga agcagcctgg ggcctcagtg aaggtctcct gcaaggtttc
       61 cggatacacc ctcaccgaag tgtccactca ctgggtgcga caggcccccg gaaaagggct
      121 tgagtgggtg ggaagtgttg atcctgcata tggtgaaatg aagttccagg gcagagtcac
      181 catgaccgag gacacgtcca cagacacagc ctacatggaa ctgagcagcc taagatctga
      241 ggacacggcc gtgtattact gtgcgattgg ccctaccggc aggtggaacg gctggtcctt
      301 cgatatctgg ggccctggca ccccaatcac catctcctca gcc
//
LOCUS       KCXD01001532             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:12847:7153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001532
VERSION     KCXD01001532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:12847:7153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60014.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       441..446
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          109 a          112 c          156 g          121 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgtaggcgg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgta gcctctggat tcaccttcag tagtagtggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt ggctggctgt tgaatcgcat
      301 gatggaaata agaaatacta tgcagactcc gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatggtata tcttcaaatg aacaacctga aattggtgga tacggccatg
      421 tattactgtg tgagagatgc ctacgggggc ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001533             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12297:3048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001533
VERSION     KCXD01001533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12297:3048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60015.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          128 c          144 g          105 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagatg cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagcgtcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aaataattca
      301 cggagagggg ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagttg agcaacctga gatcagagga cacggccgtt tattattgtg cgagtgggtt
      421 tagtatctgg ttattttacg acgttctgga ttcgtggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001534             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18422:11357
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001534
VERSION     KCXD01001534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18422:11357"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60016.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       435..446
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          116 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccattgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg ccaggctcca gggaagggtc tggagtgggt ggcagttatg tcgcatgatg
      301 gaactaagaa attctacgca gactctgtga aggaccgatt caccatctcc agggacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgagatt ggaggacgcg gccgtctatt
      421 attgtgcgag aggagactac ggtaacagcc ttgacttctg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001535             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15223:13984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001535
VERSION     KCXD01001535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15223:13984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60017.1"
                     /translation="CAAQIHSGGWSGRFDVW"
     D_segment       431..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          135 c          147 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcctggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atatgccttc acagaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggca ggtgttgatt ctgaatatgg tgaaatgatt
      301 gacgcggaga cgttccagga cagagtcacc atgaccgacg acacgtctac agatacagcc
      361 tacatggagt tgagtagcct gagatctgag gacacggccg tgtattactg tgcggcccaa
      421 attcatagtg gcggctggtc tgggcggttc gatgtctggg gcccgggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001536             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19989:12296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001536
VERSION     KCXD01001536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19989:12296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60018.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          148 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaacct ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gagcatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001537             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17475:9292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001537
VERSION     KCXD01001537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17475:9292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60019.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          118 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 agactaagaa atactacgca gactctgtga aggaccgatt cagcatctcc agagacaact
      361 ccaagaatat gctatatctt caactgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001538             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23700:6144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001538
VERSION     KCXD01001538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23700:6144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60020.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          115 c          153 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcat cttcagtagc ctcggcatgc
      241 actgggtccg ccgggctcca gggaaggggc tggagtgggt ggcagttatc tcgtctgatg
      301 gaagtcagaa atattatgca gactctatga aggaccgatt caccatctcc agagacaatg
      361 ccaagaacat gctgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccgggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001539             340 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12512:13399
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001539
VERSION     KCXD01001539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12512:13399"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..338
     V_segment       4..277
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>307
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60021.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       279..283
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..338
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>340
                     /gene="IGHG"
BASE COUNT           74 a           85 c          100 g           81 t
ORIGIN      
        1 acatggggga ggcttggttc agcctgggga gtccctgaga ctctcctgtg cagcctctgg
       61 attcaccttc agtacctctg gcatgcactg ggtccgccag gctccaggga aggggctgga
      121 gtgggtgtct gtaatttcgt ctgatggaag taagaaatac tacgcagact ctgtgaagga
      181 ccgattcacc atctccagag acaactccaa gaacatacta tatcttcaaa tgaacaacct
      241 gaaattggag gacacggccg tgtatttctg tgtgagagat gccttcgggg gcggtttgga
      301 ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001540             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17284:3125
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001540
VERSION     KCXD01001540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17284:3125"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60022.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       422..431
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          137 c          141 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat ataccttcag cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggggg tgttgaccct gtatatggtg aaatgataca
      301 cgtagagaag ttccagggca gagtcacctt gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgacga cacggccgtg tttttctgtg cagccgggta
      421 cagtggtagt tggaactcct ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001541             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15355:18296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001541
VERSION     KCXD01001541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15355:18296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60023.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          141 c          133 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaagg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatcg
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001542             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22649:11484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001542
VERSION     KCXD01001542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22649:11484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60024.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          131 c          139 g          105 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca gggctggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actggagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatccatg ggagtgatag tagtaccaag tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaatcaatgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagtattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001543             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21478:19141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001543
VERSION     KCXD01001543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21478:19141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60025.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          134 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001544             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19254:19081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001544
VERSION     KCXD01001544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19254:19081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60026.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       441..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          112 c          161 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgttattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtcact gagactctcc tgtgcagcct ctggattcac cttcagtagc tctggcatgc
      241 actgggtccg ccaggcttta gggaagggac tggagtgggt ggcactgata tcttatgatg
      301 gaagtaagaa atactacgca gaatccgtga aggaccgatt caccatctcc agagacaatt
      361 ccacgaacat gctgtatctt caaatgaaca acctgaaact ggatgacacg gccgtgtatt
      421 actgtgcgcg agttggagag ggtagtggtg gtgcggagga ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001545             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12321:15606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001545
VERSION     KCXD01001545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12321:15606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60027.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          135 c          136 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctctcagc ggtgattatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggc tatatctatg gtggtcgtgg gagcaccacc tacaacccgt ccctcaggaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttg tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagacag tgctgttact atgatgactt
      421 tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001546             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19167:16364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001546
VERSION     KCXD01001546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19167:16364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..518
     V_segment       143..434
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60028.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       470..476
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..518
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          115 a          125 c          161 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtattt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgcg cctggtgcag tctgggggcg gcctgacaaa
      181 gccggggggg tccctgagac tctcctgtgc agcctccgga ttcaccttca gtgactacta
      241 tatggactgg gtccgccagg ctccagggaa ggggctggag tgggtctcac gaatcaatca
      301 tgatggcaca agcacatggt acgcagactc cgtgaagggc agatttacca tttccagaga
      361 gaatgccaag aacacactgt ttctgcaaat ggacagcctg agaagtgagg acacagccgt
      421 atattactgt gcgagagagc ggtttggggg aattggggta attatcttca actggatcga
      481 tgtctggggt ccgggagtcc tggtcaccgt cccctcagcc
//
LOCUS       KCXD01001547             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14731:4314
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001547
VERSION     KCXD01001547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14731:4314"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60029.1"
                     /translation="CARDESSINYPFDYW"
     D_segment       432..438
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           98 a          143 c          135 g          110 t
ORIGIN      
        1 acatggggag ggtcctgctc acatgggaaa tgctctctga gagtcacgga catcctgtgc
       61 aagaacatga agtatctgtg gttcttcctc ctcctggtga cagctcccag atgggtcctg
      121 tcccaggtgc aacttcagga gtcgggccca ggacaggtga ggccttcgga gaccctgtcc
      181 ctcacctgcg ctgtctctcg tggctccatc agtggttaca ggtggagctg gatccgccag
      241 cccccaggga agggactgga gtggattgga cgcatctctg gtagtggtgg gagtaccacc
      301 tacaacccct tcctcaagag tcgagtcacc atttcaacag acacgtttaa caaccagttc
      361 tccctgaagc tgaactctgt gaccgccgca gacacggccg tctatttctg tgcgagagat
      421 gagagctcca ttaactaccc ttttgactac tggggccggg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01001548             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11249:17782
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001548
VERSION     KCXD01001548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11249:17782"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60030.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       415..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          113 a          139 c          146 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga accctggtgc ctcagtgaag ctctcctgca
      181 aggggtctgg actcaccctc agcaccgagg ccatcagttg ggtgcgacag gcccctggac
      241 aaggacctga ctggatggga gggatcatcc ctctcgtggg tgcaacaaac tacgcacaga
      301 agttccaggg cagagtcaag tttaccgcgg acacgtccat aaacacagcc tacatggaac
      361 tgagcggcct gagatctgag gacacggccg tgtattattg tgcgaaatcc gtgaattacg
      421 aggaagataa tggttactat ttaccgacgg ggtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01001549             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14663:5729
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001549
VERSION     KCXD01001549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14663:5729"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60031.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          115 c          150 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 aaccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001550             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14412:13048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001550
VERSION     KCXD01001550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14412:13048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60032.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       447..463
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          111 a          120 c          154 g          126 t
ORIGIN      
        1 acatgggggc tctaggagag gagcccagcc ctgggattcc caggtgtttt catttgtgat
       61 cagcactgaa cacagaagac tcatcatgga gtttggcctg agctgggttt tccttgttgc
      121 tattttaaaa ggtgtccagg gtgaggtgca actggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccctca gtaactactg
      241 gatgtactgg gttcgccagg caccagggaa ggggctggag tggatctcag ctattaatag
      301 tgttggtgat agcacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gagcgccaag aacacactat atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtac cgggcctagt ggtatttact gcttcacttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001551             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16200:12836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001551
VERSION     KCXD01001551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16200:12836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60033.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       415..424
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           97 a          144 c          136 g           99 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggctcttcct cctgctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagtcctcag agaccctgtc cctcacctgc gctgtctctg
      181 gtgcctccat cggtagttac tggtggacct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg ggagatcaat ggaaatagcg gtagtaccta ctacagcccc tccctcaaga
      301 gtcgagtcac catttcaaaa gacgcgtcca agaaccacca ctccctgaag ctgaactctg
      361 tgaccaccgc ggacacggcc gtgtatttct gtgcgaacgt cttaggcccc tggggcagct
      421 ggtcacacta ctttgagtac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001552             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:20850:5784
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001552
VERSION     KCXD01001552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:20850:5784"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..400
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60034.1"
                     /translation="CAKKYRGSYFYSHFDYW"
     D_segment       410..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          100 a          133 c          133 g          111 t
ORIGIN      
        1 acatggggat gctgtctgag agtcagggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcagctg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcac ctgcgctgtc
      181 tctggtggct ctatcagcga ttactcctgg agctggatcc gccagacccc agggaaggga
      241 ctggagtgga ttggagatat tgatgataat attgggggca tcaagtacaa atcctccctc
      301 aggagtcgag tcaccatttc aaaagacacg tccaagaatc agttgtccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtctat tactgtgcga aaaagtatcg tggtagttat
      421 ttctactccc actttgacta ctggggccag ggaatcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001553             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22188:8407
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001553
VERSION     KCXD01001553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22188:8407"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..520
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60035.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       446..465
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..520
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          112 a          129 c          155 g          126 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttacgacatg
      241 acctgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagttacact
      301 ggtaaaacca tatactactc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gtcaagaact ctctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgttcta gagcggctta cgaacatgat gacggttact attacgtcgg caggtttttt
      481 gactgctggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001554             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15656:4730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001554
VERSION     KCXD01001554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15656:4730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..488
     V_segment       127..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60036.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       418..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>492
                     /gene="IGHG"
BASE COUNT          119 a          142 c          132 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccacctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggctacagc ttcgccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggttttg ctagtatata tggtcaaata
      301 atacatacag agagattcca gggcagagtc accatgacag cggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctgacatct gaggacacgg ccgtgtatta ctgtgcggca
      421 gctgatagtg gttacccatt ttactacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctccg cc
//
LOCUS       KCXD01001555             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13187:4854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001555
VERSION     KCXD01001555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13187:4854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60037.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       426..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          105 a          138 c          146 g          100 t
ORIGIN      
        1 acatggggga cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcgtcc ctcttgttgg aacaacaaac
      301 tccgcacaga agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagtc
      361 tacatggagt tgagcagcct gagatctgag gacacggcca tgtattactg tgcgagaggc
      421 ctgggtagca gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01001556             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10133:8598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001556
VERSION     KCXD01001556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10133:8598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60038.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       402..415
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          133 c          140 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtacaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acttgcgttg tctctggcca
      181 ctccatcagc agtggctacc actggggctg gatccgtcag cccccaggga agggactgga
      241 ctatattggc tatatcagtg gtagtagtgg gagcacctac tacaagccct ccctcatgag
      301 tcgagtcatc atttcaagag acacgtcccg gaatgagttc tccctgaggc tgaggtctgt
      361 gactgtcgcg gacacggccg tgtattattg tgcgagacga gatagctgga acaacggggg
      421 gagccttgac tactggggcc agggattcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001557             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20999:8537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001557
VERSION     KCXD01001557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20999:8537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60039.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       439..450
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          110 a          137 c          151 g          109 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactgaaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgcgaggtg cagctggtgg agtctggggg cggcctggca
      181 aagcctgggg gagccctgag cctctcctgt gcagcctctg gattcacctt cagtacctat
      241 gctatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtctc agctattagt
      301 agtggtggca ccacatacta cgcagcctcc gtgaagggcc gattcaccgt ctccagagac
      361 aactcaaaga acacactctc cctacaaatg aacagcctga gaactgagga cacggccgtg
      421 ttttactgtg cgaaagccga tacagctaca ccatactacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001558             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12138:12367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001558
VERSION     KCXD01001558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12138:12367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60040.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           91 a          137 c          134 g           99 t
ORIGIN      
        1 acatggggga aagttctctg agagtcacgg acctcctggg caagaacatg aagcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat caacagtggt tatggctgga gctgggtccg ccagccccca gggaagggtc
      241 cggagtggat tgggtgtctc tatgatagta gtggcaacac gtactacaac ccctccctca
      301 agagtcgcgt caccatttca aaagacacgt ccaagaacca gttctccctg aacctgaggt
      361 ctatgaccgc cgcggacacg gccgtgtatt actgtgcgag atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001559             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13962:5639
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001559
VERSION     KCXD01001559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13962:5639"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60041.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          104 a          126 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtggggct aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag accacactgt atcttcacat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtaagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001560             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16501:9107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001560
VERSION     KCXD01001560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16501:9107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60042.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          143 c          135 g           95 t
ORIGIN      
        1 atggggagca tcacacaaca accacatccc tcccctacag aagccccaga gcacagtacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctgggtctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 ccccaggaag aggccttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgag atctgaggac acggccgtat attactgtgc gatcggccct agcggcagtt
      421 ggaacgcctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01001561             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21568:12510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001561
VERSION     KCXD01001561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21568:12510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..473
     V_segment       116..409
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60043.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       416..422
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          109 a          105 c          140 g          121 t
ORIGIN      
        1 acatggggag tccacagtgt tccattcggt gatcagcaca gaacacagag gactcaccat
       61 gaagtttggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
      121 acaattggtg gagtctggag gaggtttggt tcagcctggg gggtccctga gactctcctg
      181 tgaagcttct ggattcacct tcagtaacta tggcatgcac tgggtccgcc aggctccagg
      241 gaaggggctg gagtgggtgg cagttatatc gtatgatgta agtaggaaat actacgcaga
      301 ctctgtgaag gaccgattca ccatctccag agacaattct aagaacatgc tatatcttca
      361 aatgagcaac ctgaaattgg aggacacggc cgtgtatttc tgtgcgagac gcccttggaa
      421 cgctgactac tttgactact ggggccaggg agtcctggtc accgtctcgt cagcc
//
LOCUS       KCXD01001562             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:25891:20234
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001562
VERSION     KCXD01001562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:25891:20234"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60044.1"
                     /translation="CVRYEDESINYHFDSW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           93 a          134 c          128 g          104 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 agcagtagct actggaactg gatccgccag cccccaggga agggactgga gtggattggg
      241 tatatctctg gtgcttatgg gagtaccagc tacaacccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt gaccgccgcg
      361 gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta ccactttgac
      421 tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001563             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14598:14259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001563
VERSION     KCXD01001563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14598:14259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60045.1"
                     /translation="CARVGENTGGAEDFDFW"
     D_segment       440..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          112 c          157 g          124 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttggtatt
      121 ttaagaggtg tccagtgtga ggtacaactg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgaagtc tctggattca ccttcagtac ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgtcacttat atcgtatgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccgagaaca tgctatttct tcaaatgaac aacctgaaat tggacgacac ggccgtgtat
      421 ttctgtgcga gagttggaga gaatactggt ggtgcggagg actttgactt ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001564             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20720:20100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001564
VERSION     KCXD01001564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20720:20100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..508
     V_segment       139..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60046.1"
                     /translation="CSREWIQWAHLVSGLDSW"
     D_segment       435..448
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..508
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          116 a          119 c          159 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccaggcctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt ggtctgacct gggttttcct tgttggtatt
      121 ttgaaaggtg tccagtgtga ggtgcagctg gtggagtctg gaggagcctt ggctcagcct
      181 ggggggtccc tgagactctc ctgtacagcg tctgggttca ccttcagtag ctatgccatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagccat atcatttgat
      301 ggaagtaaga aaaactacgc agactctgtg aaggaccgat tcaccatctc cagagacaac
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtac
      421 tactgttcga gggagtggat acagtgggca cacttagtga gcggtttgga ttcctggggc
      481 caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001565             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12980:7947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001565
VERSION     KCXD01001565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12980:7947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..456
     V_segment       87..380
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60047.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       381..388
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT          101 a          123 c          135 g           99 t
ORIGIN      
        1 acatggggct gggagcacag ctcatcacca tggactggac ctggaggctc ctctttgtgg
       61 tggcagcagc tgcaggtgtc cagtcccagg tccgcctggt gcagtccggg gctgaggtga
      121 agaagcctgg ggcctcagtg aggatttcct gcggggcttc tggattcacc ctcgacacct
      181 atggtatcaa ctgggtgcga caggcccctg gacaagggct tgagtggatg ggagtgatca
      241 tcccccttat tggtatcata aactacgaaa agaactctca gggcagagtc acaataaccg
      301 cgaacacgtc cacaaataca gcctatatgg aactgagcag tctgagatct gaggacacgg
      361 ccatctatta ctgtgcgaga gaatactgca cttctagtac ttgcgccggg ttccttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001566             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10265:14406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001566
VERSION     KCXD01001566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10265:14406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60048.1"
                     /translation="CARAGFSGSESFYGLDIW"
     D_segment       404..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           89 a          139 c          136 g          109 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag ctcctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag tctttgggga ccctgtccct cacctgcgat gtctctggtg
      181 gctccatcag cagtaactac tggagctgga tccgccaggc ccccgggaag ggactggaat
      241 ggattggacg tttctctggt agtggtggaa acaccgacta caacccctcc ctcacctctc
      301 gagtcacctt ttcaacagac acgtccaaga accagttttc cctgaggctg aaatctgtga
      361 ccgccgcgga cacggccgtc tatttctgtg cgagagccgg atttagcggc agcgaaagtt
      421 tctacggttt ggatatttgg ggccaagggg tcgccgtcac cgtctcctca gcc
//
LOCUS       KCXD01001567             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:15313:15856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001567
VERSION     KCXD01001567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:15313:15856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60049.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          144 c          135 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccgttcactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctgtatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctgcag acacagccta catggaactg
      361 aatagcctga catctgagga cacggccgta tattactgtg cgactggccc tagcggcacc
      421 tggaacgcct ggtacctcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001568             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23863:10496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001568
VERSION     KCXD01001568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23863:10496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60050.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       291..299
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           78 a           83 c           97 g           85 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagccgga ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtttct atggcttcca ctgggtccgc caggctccag ggaaggggct
      121 ggagtgggtg tcagttattt cgaatgatga aaataacaaa tactacgcag actctgtgaa
      181 ggaccgattc accatttcta gagacaattc catgaacatg ctatttcttc aaatgaacaa
      241 cctgaacttg gacgacacgg ccgtctatta ctgtgtgaga gatgatttag gcagcggctt
      301 agggtcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001569             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22115:8718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001569
VERSION     KCXD01001569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22115:8718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60051.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          109 c          153 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgacttgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcatg ttcagtaact atggcatcca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg tcagttatat cgtatgatgt
      301 aactgtgaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacacg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ttgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      481 cgtctcgtca gcc
//
LOCUS       KCXD01001570             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16026:13938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001570
VERSION     KCXD01001570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16026:13938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60052.1"
                     /translation="CARGDIGNGVDYW"
     D_segment       439..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          108 a          115 c          154 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tatgttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgta
      301 tgatgaaatt acgaaatact acgcagactc tgcgaaggac cgattcacca tctccagaga
      361 caattccaag aatatggtat atcttcaaat gaacagcctg aaattggagg acacggccgt
      421 gtatttctgt gccagagggg atattggtaa tggcgtcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctctgcc
//
LOCUS       KCXD01001571             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14229:10207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001571
VERSION     KCXD01001571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14229:10207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60053.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       448..458
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          110 a          131 c          152 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtc
      181 cagcctgggg ggtccctgag actctcctgt acagccactg gattcacctt cagtagtttt
      241 ggcatgagct gggtccgcca gcctccaggg aaggggctgg agtgggtctc atacattagt
      301 aatagtggta gtagcacata ctacgcagac tccgtgaagg gccgattcac catctccaga
      361 gacaactcaa agaacacgct ctccctgcaa atgaacagcc tgacagctga ggacacggcc
      421 gtgtatcact gtgcgaaaca tcgtttcagc agctggtcgt atttccttga cttctggggc
      481 cagggaatcc tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01001572             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24367:12184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001572
VERSION     KCXD01001572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24367:12184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..271
     V_segment       8..195
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60054.1"
                     /translation="CARDCGGIYCTVLGLDSW"
     D_segment       211..220
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       229..271
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           55 a           70 c           83 g           65 t
ORIGIN      
        1 acatggggga tccgccagcc cccagggagg gcactggagt ggattgggta tatctatggt
       61 ggtgatggga ggaccaggta caacccctcc ctcaagagtc gagtcatcat ttcaagagac
      121 acgtccaaga accagttctc cctgaagttg agttctgtga ccgccgcgga cacggccgtt
      181 tattactgtg cgagagattg tggtggaatt tactgtactg ttctcggctt ggattcctgg
      241 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001573             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24192:10157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001573
VERSION     KCXD01001573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24192:10157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60055.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          115 c          158 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      181 cagccggggg ggtccctgag actctcctgt gcggcctctg gattcacctt cagaacctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ggttatatcg
      301 aatgatgaaa ctaacaaata ctacggagac tctgtgaagg gccgattcag catctccaga
      361 gacaattcga agaacatgct atatcttcaa atgaacaccc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgacaga tgcgtttggt agtgggattg accactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001574             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15084:16709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001574
VERSION     KCXD01001574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15084:16709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    80..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        80..452
     V_segment       80..371
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <365..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60056.1"
                     /translation="CARDYSVTMSIYFTRFDVW"
     D_segment       381..389
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..452
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           98 a          109 c          137 g          110 t
ORIGIN      
        1 acatggggac acacaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
       61 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggcacagcc
      121 tggggggtcc ctgagactct cctgcgcagc ctccggattc agcttcagtg agtcctacat
      181 ggactgggtc cgccaggctc cagggaaggg gctggagtgg gtctcacgta ttagtaatgg
      241 tggtgataaa atatggtacg cagactccgt gaaggacaga ttcaccatct ccagagagaa
      301 cgccaagaaa acactgtatc ttcaaatgga cggcctgaga gctgaggaca cggctgtcta
      361 ttactgtgcg agagattatt cagtaactat gtccatttac ttcacccgat tcgatgtctg
      421 gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001575             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6864:15381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001575
VERSION     KCXD01001575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6864:15381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60057.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          109 c          154 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttattgcta
      121 ttttaagagg tgtccagtgt gaggtgcacc tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt catgttcagt aactatggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtcagtt atatcgtatg
      301 atgtaactgt gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa tacggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgtgt gagagatgtc aggggaacgg ggtttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc gtcagcc
//
LOCUS       KCXD01001576             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10416:2908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001576
VERSION     KCXD01001576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10416:2908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60058.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          119 c          148 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccgga gtgaggtgca actggtggag tccggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca ctaactatgg
      241 catgcactgg gtccgccagg ctccagggaa gggactggag tgggtggcag ttatttcgtc
      301 tgatggaagt aagaaatact acgcaacctc tgtgagggac cgcttcacca tctccagaga
      361 caattccaag aacatacttt atcttcaaat gaacaacctg aaattggaag acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001577             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17435:17129
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001577
VERSION     KCXD01001577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17435:17129"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60059.1"
                     /translation="CARPRSIGVRYLGYW"
     D_segment       419..424
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           94 a          138 c          136 g           97 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag ggctggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcggttacta ctggaactgg atccgccaac ctccagggaa ggggctggag
      241 tggattggat atatcggtgg gagtagtggg atcacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgagact gacctctgtg
      361 accgccgcgg acacggccgt atattactgt gcgagaccaa ggagcatagg ggtgcgatac
      421 ctgggctact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001578             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27588:20210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001578
VERSION     KCXD01001578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27588:20210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60060.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          116 c          149 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgct actggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 cttccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tttctagaga
      361 caattccatg aacatgcttt ttcttcaaat gaacaacctg aacttggacg acacggccgt
      421 ctattactgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001579             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13305:6031
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001579
VERSION     KCXD01001579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13305:6031"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60061.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          115 a          142 c          130 g           92 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctacactgg gtgcgacagg
      241 ctcctgggaa aggacttgag tggatgggag gtgttcatcc tgaatatgga aaagtagact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac ttctggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001580             396 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12819:24632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001580
VERSION     KCXD01001580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12819:24632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    13..394
                     /note="immunoglobulin heavy chain variable region"
     V_region        13..394
     V_segment       13..310
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <301..>363
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60062.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       316..333
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       347..394
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        395..>396
                     /gene="IGHG"
BASE COUNT           94 a          110 c          103 g           89 t
ORIGIN      
        1 acatgggtgt cccaggtcac cttgaaggag tctggtcctg cgctcgtgaa acccacacag
       61 accctcacgt tgacctgcac cttctctggg ttctcaatca gctctactgg aagaggtgtg
      121 ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccat ttattggaat
      181 gatagtaaat actacagcac atcgctgaag agcaggctca ccgtctccaa ggacacctcc
      241 aaaaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc caaatattac
      301 tgtgcacggg attactgtag tgggatttac tgcgatgtaa atgggcacta ctttgacctc
      361 tggggccagg gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01001581             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18705:13255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001581
VERSION     KCXD01001581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18705:13255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..271
     V_segment       8..195
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60063.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       204..212
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       224..271
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           60 a           77 c           79 g           57 t
ORIGIN      
        1 acatggggga tccgccagcc cccagggaag gggctggagt ggattgggtt tatcggtggt
       61 ggtagtggga gcaccgaata caacccctcc ctcaaaagtc gagtcaccat ttcaagagac
      121 acgtccaaaa atcaattctc cctgaagctg gcctctatgg ccgccgcgga cacggccgtt
      181 tatttctgtg ccagagatgc gggagtggga gccacaatcc tttactacta tgactactgg
      241 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001582             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17175:19729
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001582
VERSION     KCXD01001582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17175:19729"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60064.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          137 c          128 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctactggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gactccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001583             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11431:6884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001583
VERSION     KCXD01001583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11431:6884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..464
     V_segment       98..389
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60065.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       403..409
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..464
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          111 a          130 c          132 g           93 t
ORIGIN      
        1 acatggggcc tacagaagcc ccagagcaca gcacctcacc atggactgga cctggaggat
       61 cctcctcttg gtggcagcag ctacaggcgc ccactctgag gtccagctgg tgcagtctgg
      121 ggctgaggtg aagaaccctg gggcctcagt gaaggtctcc tgcaaggttt ccggatacat
      181 cttaaccgaa ttatccatac actgggtgcg acaggcccct ggaaaagggc ttgagtggat
      241 gggaagtgtt gatcctcaat atggtgaaat gatagacgca gagaaattcc agggcagagt
      301 caccatgacc gaggacacgt ctacagacac agcctacttg gagctgagca gtctgagatc
      361 tgaggacacg gccgtgtatt actgtgcgac ctcatccagc ggcacctggc tatactggta
      421 cttcgatatc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01001584             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14467:10257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001584
VERSION     KCXD01001584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14467:10257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60066.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          115 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agcaactctg
      241 gcattcactg ggtccgccag gctccagggg aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaag taagacatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatggta catcttcaaa tgaacaccct gaatttggag gacacggccg
      421 tatattactg tgtgagagat tcttacggta gaggctttga ccagtggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001585             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19212:13988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001585
VERSION     KCXD01001585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19212:13988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60067.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       446..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          109 a          117 c          152 g          120 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctggaggagg cttggttcgg
      181 ccgggggggt ccctgagact ctcctgtaca gcctctggat tcaccttcag taattttggc
      241 atccactggg tccgccaggc tccagggaag ggcctggagt gggtggcagt tatatcgtct
      301 gatgaaagta agaaatacta tgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatggttta tcttcagatg aacaacctga agttggacga cacggccgtc
      421 tattactgtg cgagagacgc atttggcagc ggctgtgact tctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001586             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15201:13852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001586
VERSION     KCXD01001586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15201:13852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..415
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60068.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       425..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT           95 a          145 c          146 g          110 t
ORIGIN      
        1 acatgggggt ctccctcacc gcacagctgg gatctcagtg cttccttttc tgtcctccac
       61 cacgatgggg tcaactgcca tcctcaccct cctactggct gttctccaag gagtctgtgc
      121 cgaggtgcag ctggtgcagt ctggagcaga ggtgaaaagg cccggggagt ctctgaagat
      181 ctcctgtaag acttctggag acacctctag ctactattgg atcagctggg tgcgccagat
      241 gcccgggaaa ggcctggagt ggatgggggc gattgatcct ggtgattctg ataccaaata
      301 tagtccgtcc ttccaaggcc aggtcaccat ctcagccgac aagtccatca gtaccgccta
      361 cctgcagtgg agcagcctga aggcctcgga caccgccacg tattactgtg cgaaaggggg
      421 gtggtggggt gattatccac cctcagactg gctcgatgtc tggggcccgg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001587             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16026:5109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001587
VERSION     KCXD01001587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16026:5109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60069.1"
                     /translation="CARDWLGGYGLDSW"
     D_segment       411..418
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          126 c          136 g          109 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agtgatgggt acaggtggag ttggatccgc cagtccccag ggaagggact
      241 ggagtggatt gggtacatct atggtagtaa tacgaggacc acctacaacc cctccctcaa
      301 aagtcgagtc accatttcaa aagacacgtc caagaaccaa atctccttga atctgaattc
      361 tgtgaccgcc gcggacatgg ccctgtatta ctgtgcgaga gattggttgg ggggatacgg
      421 tttggattcc tggggcctag gtgtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001588             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:19114:9860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001588
VERSION     KCXD01001588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:19114:9860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60070.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       268..273
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           74 a           79 c           96 g           73 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagtctct gggttcacct tcagtggctc
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gaatgggtgg cggttatatc
      121 gaatgatgga actaacaaat actacgcaga ctctctgaag gaccgattta gtatctccag
      181 agagaattcc aagaacatgc tatatcttca aatgaacaac ctgaaactgg aggacacggc
      241 cgtctattac tgcgcgacag atgcgtttgg tagcgggatt gactactggg gccggggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001589             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12435:9323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001589
VERSION     KCXD01001589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12435:9323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60071.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       435..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          114 c          143 g          122 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcga ttttaagagg
      121 tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc cggaggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt ttctatggct tccactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcgaatg atgaaaataa
      301 caaatactac tcagactctg tgaaggaccg attcaccatt tctagagaca attccatgaa
      361 catgctattt cttcaaatga acaacctgaa cttggacgac acggccgtct attactgtgt
      421 gagagatgat ttaggcagcg gcttagggtc ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001590             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12120:12754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001590
VERSION     KCXD01001590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12120:12754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60072.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       446..451
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          103 a          115 c          163 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 tagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaca
      181 gcctgggggg tccctgagac tctcctgttc agcctctggg ttcaccttca gtaggcactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctagag tgggtctccg gtattaatag
      301 tggtggggat actacatact acgtagactc cgtgaagggc cgattcacca tgtccagaga
      361 caattcaaag aacactctct ccctgcaaat gaacagcctg agagcggagg acacggccgt
      421 gtattattgt gtgcaagggg aaatttttgg agtgggtttg gatttctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001591             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11752:17687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001591
VERSION     KCXD01001591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11752:17687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60073.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          143 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001592             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20557:17206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001592
VERSION     KCXD01001592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20557:17206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..489
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60074.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       411..432
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT           98 a          142 c          135 g          116 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gtggctctat cagcagtact aaatggtgga gctggatccg ccagccccca gggaaagggc
      241 tggagtggat tgggtatatc agtggtagta gtggtaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca acggacacgt ccaacaacca gttctccctg aagctgagct
      361 ctgtgaccgc cgcggacacg gccgtttatt attgtgcgag atcccaatcc tattgtagtg
      421 ggctttactg cttcggctac tactactttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001593             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21839:13200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001593
VERSION     KCXD01001593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21839:13200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..430
     V_segment       76..369
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60075.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       376..388
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..430
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT           95 a           90 c          138 g          109 t
ORIGIN      
        1 acatggggag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
       61 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggctgggt tcagccgggg
      121 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagcaa cggcatgcac
      181 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagtgatatc gtttgatgaa
      241 agtaagaaat actacgtaga ttctgtgaag gaccgattca ccgtctccag agacaattcc
      301 aagaacatgg tatatcttca aatgaacaac ttgaaattgg aggacacggc cgtgtattac
      361 tgtgtgagag actcttatgg aagtggtttg gattcctggg gccaaggggt cgtcgtcacc
      421 gtctcctcag cc
//
LOCUS       KCXD01001594             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:23289:11937
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001594
VERSION     KCXD01001594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:23289:11937"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..473
     V_segment       95..388
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60076.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       412..420
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          105 a          134 c          143 g           93 t
ORIGIN      
        1 acatggggag aagcccctgg gaacacagct catcaccatg gacttgacct ggaggctcct
       61 ctttgtggtg gcagcggcta caggtgccca gtcccaggtc cagctggtgc agtccggggc
      121 tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc aaggcttctg gatacacctt
      181 cagcatccat ggcatcagtt gggtgcgaca ggcccctgga caagggcttg agtggatggg
      241 agggatcatc cctcttgttg atttaacaca ctacgcacag aagttccagg gcagagtcac
      301 gattaccgcg gacacgccca caagcacagc ctacatggag ctgagcagcc tgagatctga
      361 ggacacggcc ttttattact gtgcgagagg gacaacccac ctcgagatgg caactggaat
      421 cggagactac tttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001595             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16435:10932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001595
VERSION     KCXD01001595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16435:10932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60077.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          140 c          136 g          104 t
ORIGIN      
        1 acatggggag cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag
      121 tcccaggtcc gcctggtgca gtccgggact gaggtgaaga agcctggggc ctcagtgaag
      181 atttcctgcg gggcttctgg attcaccctc gacacctatg gtatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccttattgg tatcatcaac
      301 tacgcagaga actctcaggg cagactcaca ataaccgcga acacgtccac aaatacagcc
      361 tatatggaac tgagcagtct gagatctgag gacacggcca tctattactg tgcgagagaa
      421 tactgtactt ctagtacttg cgccgggttc cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001596             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22373:20490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001596
VERSION     KCXD01001596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22373:20490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60078.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          120 c          146 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga atgggtgtca gttatttcgc
      301 atgatggaac taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccga gaacaaacaa tatcttcaca tgaatgacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga atactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001597             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11377:8770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001597
VERSION     KCXD01001597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11377:8770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60079.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       442..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          121 c          157 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggtaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttatttctac
      241 atgagctggg tccgtcaggc tccagggaag gggctggagt ggatctcaag tattgacagt
      301 ggtgggacta ccacaaatta tgcagactcc gtgaggggca gcttcaccat ctccagagag
      361 aacgccaaga acagactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattattgtg cgagagcgcg cggggtgatc attacatact ttgactcctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001598             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21567:7251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001598
VERSION     KCXD01001598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21567:7251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..450
     V_segment       93..386
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60080.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       393..399
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT          105 a          101 c          132 g          114 t
ORIGIN      
        1 acatggggat cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt
       61 tccttgttgc tattttaaga ggtgcccagt gtgaggtaca attggtggag tctggaggag
      121 gtttgggtca gcctgggggg tccctgagac tctcctgtga aacttctgga ttcaccttca
      181 gtaattatgg catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag
      241 ttatttcgta tgatgtaagt aagacatact acgcagactc tgtgaaggac cgattcacca
      301 tctccagaga caattctaag aacatgctat atcttcaaat gagcaacctg aaattggagg
      361 acacggccgt gtatttctgt gcgagacgcc cttggaacgc tgactacttt gactactggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001599             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15118:15173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001599
VERSION     KCXD01001599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15118:15173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60081.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       435..445
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          120 a          147 c          141 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctccccaac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg acttgttgat cctgtaaatg gtgaactaat
      301 acacgcagac aacttccagg gcagagtcac catgaccgaa gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgacatctga ggacacggcc atctactact gtgcgacagg
      421 gaggatcggt accagtggct ggtccaacct cttcaatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01001600             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14152:21040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001600
VERSION     KCXD01001600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14152:21040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60082.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       431..436
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          147 c          138 g           91 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccgct
      121 ctgaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattctc cacgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgcatatggt gaaatgacac
      301 acgcagaaaa cttccagggc agactcacca tgaccgagga cacgtctaca gacacggcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtattattgt gcgagatcat
      421 ccagcggtac gtggctatac tggtacttcg atacctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001601             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24549:13844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001601
VERSION     KCXD01001601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24549:13844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60083.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       399..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          138 c          139 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctctggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatgagc agtcactact gcagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgg atctctggta gtggtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccctc tcaacagaca cgtccaagaa ggagatctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagaagac tatggtggta attattactt
      421 taaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001602             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10059:5750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001602
VERSION     KCXD01001602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10059:5750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..347
     V_segment       7..286
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <278..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60084.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       295..301
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..347
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>349
                     /gene="IGHG"
BASE COUNT           79 a           85 c          104 g           81 t
ORIGIN      
        1 acatggggaa tctggaggag gcttggttca gcctgggggg tccctgagac tctcctgtgc
       61 agcctctgga ttcaccttca gtagctttgg catgcactgg gtccgccagg ctccagggaa
      121 ggggctggag tgggtggcag ttatatcgtc tgatgaaagt aagaaatact acgccgactc
      181 tttgaaagac cgattcacca tatccagaga cgactccagg aacatgctat atcttcaact
      241 gaacaacctg aaattggacg acacggccgt gtattactgt gcgagagatg tgtatggctg
      301 ggggcttgac tactggggcc agggagtcct agtcaccgtc tcctcagcc
//
LOCUS       KCXD01001603             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21554:16271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001603
VERSION     KCXD01001603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21554:16271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60085.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       410..417
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          149 c          124 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtac aagaacatgc agtatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agtcgtaact ggtggagttg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctctg gtagtcttgg aagcaccagt aacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagacat tcagaccccg caactactag
      421 ctggtacttc gatctctggg gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01001604             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14817:14934
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001604
VERSION     KCXD01001604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14817:14934"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..498
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60086.1"
                     /translation="CATADYGNSLDYW"
     D_segment       442..453
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>501
                     /gene="IGHG"
BASE COUNT          116 a          120 c          146 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagta caactggtgg agtctggggg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagattt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc agttatatcg
      301 tctgatggaa gtatggaatt ctacgcagac tctatgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatctccaa atgaacaacc tgaaattgga ggacactgcc
      421 gtttattact gtgcgacagc cgactacggt aacagccttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcaac c
//
LOCUS       KCXD01001605             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:9410:15696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001605
VERSION     KCXD01001605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:9410:15696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..271
     V_segment       8..195
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60087.1"
                     /translation="CARDAGVGAIALYYYDYW"
     D_segment       204..209
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       224..271
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           62 a           74 c           83 g           54 t
ORIGIN      
        1 acatggggga tccgccagcc cccagggaag ggactggagt ggattggggg tgtcggtggt
       61 ggtagtggga tcaccgaata caatcccacc ctcaaaagtc gagtcactat ttcaagagac
      121 acgtccaaga accaattctc cctgaaactg agctctatga ccgccgcgga cacggccgtg
      181 tactactgtg cgagagatgc gggagtgggg gccatagccc tttactacta tgactactgg
      241 ggccagggag tcttggtcac cgtctcctca gcc
//
LOCUS       KCXD01001606             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8945:8609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001606
VERSION     KCXD01001606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8945:8609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..520
     V_segment       145..444
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60088.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       447..453
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..520
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          116 a          126 c          159 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattc ccaggcgtct ccacttggtg
       61 atcagcactg aacacaagag actcaccatg gagtttgcac tgagctgggt tttcgttgtt
      121 gctactttaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcaggctctg gattcacctt cagtgactat
      241 gccatgagct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      301 agcaaatctt acaattacgc gacagaatac gccgcatcgg tgaaaggcag gttcaccatc
      361 tccagagatg attcaaagta cacgctacat ctgcaaatga gcagcctgaa aaccgaggac
      421 acggccgtgt attactgtgc tagaggggat ataccggcta tagaggccta ctacggtttg
      481 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001607             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8540:8697
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001607
VERSION     KCXD01001607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8540:8697"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60089.1"
                     /translation="CARAGYSGSESFYGLDIW"
     D_segment       403..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          140 c          134 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gctcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaactgca gctgcaggag
      121 tcgggcccag gactggtgaa gtctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaactc ctggagctgg atccgccagc cccccgggaa gggactggaa
      241 tggattggac gtttctctgg tagtggtgga aacaccgact acaacccctc cctcaagact
      301 cgagtcacct tttcaacaga cacgtccacg aaccagtttt ccctgaggct gaaatctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagccg gatatagcgg cagcgaaagt
      421 ttctacggtt tggatatttg gggccaaggg gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01001608             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:9988:5011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001608
VERSION     KCXD01001608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:9988:5011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60090.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          138 c          133 g           96 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagg tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01001609             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16631:13806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001609
VERSION     KCXD01001609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16631:13806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60091.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          111 c          160 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg gtccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaagt aggacatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtgt atgttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001610             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7230:7094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001610
VERSION     KCXD01001610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7230:7094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60092.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       454..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          104 a          124 c          158 g          122 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtcttgccag
      301 tggtggggat agcacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagttgaag acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcattatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001611             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:3547:11533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001611
VERSION     KCXD01001611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:3547:11533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60093.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          118 c          155 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagcctgg
      181 ggggaccctg agactctcct gcgcagcctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgt caggctccag ggaaggggct ggagtggatc tcaagtattg acaatggtgg
      301 gactaccgca atttatgcag actccgtgag gggcagattc agcatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcacgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001612             381 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:2878:17909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001612
VERSION     KCXD01001612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 381)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 381)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:2878:17909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    13..379
                     /note="immunoglobulin heavy chain variable region"
     V_region        13..379
     V_segment       13..306
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <298..>348
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60094.1"
                     /translation="CARVPGLVVFTGSLDCW"
     D_segment       317..331
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       338..379
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        380..>381
                     /gene="IGHG"
BASE COUNT           85 a           95 c          120 g           81 t
ORIGIN      
        1 acatgggagg gtgaggtgca actggtggag tctgggggcg gcttggcaaa gcctgggggg
       61 tccctgagac tctcctgtgc agcctctgga ttcaccatca gaaactactg gatgtactgg
      121 gttcgccagg caccagggaa ggggctggag tggatctcag ccattaatag tgctgaaagt
      181 accacatact atgcagacgc cgtgaagggc agattcagca tctccagaga caacgccaag
      241 aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt ctattactgt
      301 gcgagagtac cgggcctagt ggtgtttact ggttcccttg actgctgggg ccagggagtc
      361 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001613             541 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:17865:4910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001613
VERSION     KCXD01001613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 541)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 541)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:17865:4910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    185..539
                     /note="immunoglobulin heavy chain variable region"
     V_region        185..539
     V_segment       185..478
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <470..>508
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60095.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       487..491
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       497..539
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        540..>541
                     /gene="IGHG"
BASE COUNT          121 a          133 c          161 g          126 t
ORIGIN      
        1 acatgggggc tccctctgct gatgaaaacc agcccagccc tgaccctgca gctctgggag
       61 aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag aacacagagg
      121 actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa gaggtgtcca
      181 gtgtgaggtg cagctggtgg agtctggagg cggcttggtt cagcctgggg ggtccctgag
      241 actctcctgt gcagcctctg gattcacctt cagtagttat ggcatacact gggtccgcca
      301 ggctccaggg aaggggctgg agtgggtgac agttatctca tttgatgaaa ctaagaaata
      361 ctacgcagac tctgtgaggg accgattcac catctccaga gacaattcca aaaacatggt
      421 atatcttcac atgaacaacc tgaaattgga ggacacggcc gtatattact gtgcgagaga
      481 tgtcaggggg acggggtttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc
      541 c
//
LOCUS       KCXD01001614             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20122:18507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001614
VERSION     KCXD01001614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20122:18507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60096.1"
                     /translation="CARRKYSGYTYGGANFDFW"
     D_segment       400..413
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          133 c          148 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggg cttcggaggc cctgtccctc acctgcactg tctctggtgg
      181 ctccatgagc ggttactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggggt atcggtggtg gtagtgggag caccgattac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtacaagaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc aagaaggaaa tacagcgggt acacgtacgg
      421 aggggcgaac tttgactttt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001615             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15745:7462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001615
VERSION     KCXD01001615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15745:7462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60097.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          136 c          142 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgatttgt ccatacactg ggtgcgacag
      241 gccactggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgacg
      301 ttccagggga gagtcaccat gaccgaggac acgtctacag acacggccta catggagctg
      361 agtagcctga gatctgagga cacgggcgtg tattactgtg cgattggccc tagcggcagg
      421 tggaaccact ggtccttcga gatctgggga cctgggaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001616             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9621:23006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001616
VERSION     KCXD01001616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9621:23006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..518
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60098.1"
                     /translation="CTAEITVEIVATPRSYDYW"
     D_segment       445..470
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          121 a          126 c          150 g          123 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggagact tagtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcagtg actatgccat
      241 gggctgggtc cgccaggctt ctgggaaagg actggagtgg gttggctata ttagaagcaa
      301 ctataaccat tacgcgacag aatacgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacgc tatatttgca aatgagcagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgcaccgcag aaatcactgt agagatagtg gctactcctc gttcttatga
      481 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001617             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14944:11365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001617
VERSION     KCXD01001617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14944:11365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60099.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          112 c          157 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtccggggg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt acagcctctg gattcatgtt cagtaactat
      241 ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtgtc agttatatcg
      301 tatgatgtaa ctgtgaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattatt gtgtgaggga tgtcagggga acggggtttg acttctgggg ccagggagtc
      481 ctggtcaccg tctcgtcagc c
//
LOCUS       KCXD01001618             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14226:7263
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001618
VERSION     KCXD01001618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14226:7263"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60100.1"
                     /translation="CSRDPVDCSGSDCYAFDYW"
     D_segment       425..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          121 a          142 c          128 g          104 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaat tggtgcagtc tggggctgaa actaagcagc ctggggcctc agtgaaactc
      181 tcctgcaagg cttctggata tagcttcact aactaccaca tgcactggtt gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt acaatggtta caaagcctac
      301 gcacagaact tccagggcag agtcaccata actgcggaca cgtccacgag cacaggctac
      361 atggagctga gcagcctgag atctgaggac acagccgtgt attactgttc gagagaccct
      421 gtagactgtt ctggtagtga ttgctacgcc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001619             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9030:21428
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001619
VERSION     KCXD01001619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9030:21428"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..517
     V_segment       142..433
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60101.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       469..475
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..517
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          114 a          125 c          161 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtatttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcgc ctggtgcagt ctgggggcgg cctgacaaag
      181 ccgggggggt ccctgagact ctcctgtgca gcctccggat tcaccttcag tgactactat
      241 atggactggg tccgccaggc tccagggaag gggctggagt gggtctcacg aatcaatcat
      301 gatggcacaa gcacatggta cgcagactcc gtgaagggca gatttaccat ttccagagag
      361 aatgccaaga acacactgtt tctgcaaatg gacagcctga gaagtgagga cacagccgta
      421 tattactgtg cgagagagcg gtttggggga attggggtaa ttatcttcaa ctggatcgat
      481 gtctggggtc cgggagtcct ggtcaccgtc ccctcagcc
//
LOCUS       KCXD01001620             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20469:4007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001620
VERSION     KCXD01001620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20469:4007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..243
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <237..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60102.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       261..270
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..330
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           73 a           85 c          103 g           71 t
ORIGIN      
        1 acatgggggt ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg
       61 tgcgacaggc ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg
      121 aagaaatata cgcagagagg ttccagggca gagtcaccat gaccgaggac acgtcgacag
      181 acacagccta catggacttg accagtctca gatctgagga cacggccatc tattactgtg
      241 cgacagggag gatcggtagt agcggctggt ccagcctctt caccggtttg gattcctggg
      301 gccgaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001621             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22114:13741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001621
VERSION     KCXD01001621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22114:13741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60103.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          137 c          130 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt acatctatgg tagtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcgcca tttcaacaga cacgtccaag aatcagttct ccctgaaact gaactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg gagatgatag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001622             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20869:14566
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001622
VERSION     KCXD01001622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20869:14566"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60104.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          119 c          147 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttcc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtttatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001623             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18291:14304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001623
VERSION     KCXD01001623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18291:14304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..458
     V_segment       89..382
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60105.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       383..387
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           98 a          134 c          133 g           95 t
ORIGIN      
        1 acatggggcc ctgggagcac agctcatcac catggactgg acctggaggc tcctctttgt
       61 ggtggcagca gctgcaggtg tccagtccca ggtccacctg gtgcagtccg gggctgaggt
      121 gaagaagcct ggggcctcag tgaaaatttc ctgcggggct tctggattca ccttcgacac
      181 ccatggtatc aactgggtgc gacaggcccc tggacaagga cttcagtgga tgggagtgat
      241 catccccctt attggtatca ccaactacgc aaagaactct cagggcagag tcacactaac
      301 cgcggacacg tccacaaaca cagcctacat ggagctgaac agcctgagat ttgaggacac
      361 ggccatctac tactgtgcga gagaacgctg cacttctagt gtttgcgccg ggttccttga
      421 ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001624             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14422:6710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001624
VERSION     KCXD01001624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14422:6710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60106.1"
                     /translation="CARKPDTIVAANFHYW"
     D_segment       406..411
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           98 a          141 c          126 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctgatgg
      181 ctctatcagc agtagtaact ggtggacctg gatccgccag cccccaggga aagggctgga
      241 gtggattgga tatatcagtg gtaacagtag tcgcacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaatag acacgtccaa gaaccggttc tccctgatac tgacctctgt
      361 gaccgccgcg gacacggccc tatatttttg tgcgaggaaa ccagatacga tcgtagccgc
      421 taactttcac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001625             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14360:9631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001625
VERSION     KCXD01001625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14360:9631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60107.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       439..446
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          121 a          143 c          139 g          102 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggttaag aagcctgggg cctcagtgag
      181 ggtctcctgc caggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgat cctgtaaatg gtgaaataat
      301 acacgcagac aacttccagg gcagagtcac catgaccgaa gacacgtcta tagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga ggatacggcc gtatattact gtgcgaccca
      421 cggaggctat agtgacatct ggaactccct gtactacggt ttggattcct ggggccaagg
      481 ggtcttcgtc accgtctcct cagcc
//
LOCUS       KCXD01001626             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:20981:15512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001626
VERSION     KCXD01001626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:20981:15512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60108.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       433..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          146 c          141 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tccccaacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggac ttgttgatcc tgtaaatggt gaactaatac
      301 acgcagacaa cttccagggc agagtcacca tgaccgaaga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg acatctgagg acacggccat ctactactgt gcgacaggga
      421 ggatcggtac cagtggctgg tccaacctct tcaatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01001627             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:3882:11495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001627
VERSION     KCXD01001627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:3882:11495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60109.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          113 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga atccctgaga ctctcctgtg cagcctctgg attcagcttc agtaactctg
      241 gcattcactg ggtccgccag gctccagggg aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaag taagacatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatggta catattcaaa tgaacaccct gaatttggag gacacggccg
      421 tatattactg tgtgagagat tcttacggta gaggctttga ccagtggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001628             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20702:6099
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001628
VERSION     KCXD01001628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20702:6099"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60110.1"
                     /translation="CATGTIGSSVWSNLFTGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          146 c          145 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctggg aaagggcttg agtggatggg agttgttgat cctgtcaatg gtgaagaaat
      301 acacgcagag aagttccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattatt gtgcgacagg
      421 gacgatcggt agcagcgtct ggtccaacct cttcaccggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001629             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16379:17611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001629
VERSION     KCXD01001629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16379:17611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60111.1"
                     /translation="CARVRGWYLGYFDYW"
     D_segment       399..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           94 a          141 c          129 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtgg
      181 ctccatcaac aataactact ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atcgctggca ctggtggaaa caccgactac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtgcgc ggctggtact taggctactt
      421 tgactattgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001630             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20020:11267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001630
VERSION     KCXD01001630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20020:11267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60112.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          114 c          146 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacaca gactctgtga agagccgatt caccatctcc agagacaatt
      361 cccagaacat actttatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001631             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10512:10370
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001631
VERSION     KCXD01001631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10512:10370"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60113.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          122 c          159 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggagagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001632             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19680:18600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001632
VERSION     KCXD01001632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19680:18600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60114.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       445..458
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          113 c          154 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag atacagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtttgatg
      301 gaagtaagaa atactacgca gactctatga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctagatctt caaatgagca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag aatggattgt actggtggtg tctgctactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001633             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17723:18137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001633
VERSION     KCXD01001633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17723:18137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60115.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       431..436
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           96 a          147 c          132 g          114 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa accttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc atatcagtgg gagtagtggg agcaccgact acaacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag agccacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagc tttcccccta cgactatttt
      421 tggagtgatt tttactctta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01001634             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17732:11347
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001634
VERSION     KCXD01001634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17732:11347"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..397
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60116.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       413..420
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           98 a          140 c          130 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgaagc tgcaggagtc
      121 gggtccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctatcagc ggtgtttatg actggacctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatgtccatg gtgatactgg gaacaccgac tacaacccgt ccctcaagaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgacgc tgaggtctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagacgc ccagaaaaca gttactactt
      421 ctactacttt gactactggg gccacggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001635             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21325:19508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001635
VERSION     KCXD01001635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21325:19508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..330
     V_segment       1..265
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60117.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       272..281
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           57 a          104 c           98 g           73 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt ggctccatca
       61 gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag tggattgggt
      121 ttttcggtgg ttatggtggg agcacctact acaacccctc cctccagagt cgagtcacca
      181 tttcagccga cacgtccaag caccagttct ccctgatact gacctctgtg accgccgcgg
      241 acacggccct ctactactgt gcgaggggga atatagcagc gactggcatt gactactggg
      301 gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001636             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14736:7454
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001636
VERSION     KCXD01001636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14736:7454"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60118.1"
                     /translation="CAAGHSGTWIHWYFDLW"
     D_segment       424..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          144 c          137 g           91 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gcaacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca gcttcaccga gttatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggcgt tgatcctgca tatggtgaat ttacacccgg
      301 agagaagttc cagggcagag taacaatgac cgaggacacg tctatagaca cagcctacat
      361 ggaactgagc agcctgaact ctgaggacac ggccgtctat tactgtgcag ccgggcacag
      421 cggcacctgg atccactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01001637             340 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23061:10274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001637
VERSION     KCXD01001637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23061:10274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..338
     V_segment       8..277
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>307
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60119.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       288..292
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..338
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>340
                     /gene="IGHG"
BASE COUNT           70 a          102 c           94 g           74 t
ORIGIN      
        1 acatggggga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
       61 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      121 gtggattggg tgtatcggtg gtaatagtgg taccacctac tacaacccct ccctcaagag
      181 tcgagccacc atttcaaaag acacgtccaa caatcaactc tccctgaagg tgagttctgt
      241 gaccgccgcg gacacggccg tgtattactg tgcgagagat gaagacccct ccatttttga
      301 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001638             401 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24133:10037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001638
VERSION     KCXD01001638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 401)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 401)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24133:10037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    36..399
                     /note="immunoglobulin heavy chain variable region"
     V_region        36..399
     V_segment       36..329
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <321..>368
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60120.1"
                     /translation="CVRYEDEYSDYYFDYW"
     D_segment       338..353
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       354..399
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        400..>401
                     /gene="IGHG"
BASE COUNT           79 a          116 c          117 g           89 t
ORIGIN      
        1 acatgggggt ctctctgttc acaggggtcc tgtcccaggt gcagctgcag gagtcgggcc
       61 caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct ggtggctcca
      121 tcaccagtag ctactggaac tggatccgcc agaccccagg gaaggggctg gagtggattg
      181 ggtctatcta tggtggtact gggagcaccg gctacaatcc ctccctcaag agtcgagtca
      241 ccatttcaac agacacgtcc aagaaccagt tttccctgag gctgagctct gtgaccgccg
      301 cggacaccgc cgtgtattac tgtgtgagat atgaggatga atacagtgac tactactttg
      361 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001639             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15838:7203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001639
VERSION     KCXD01001639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15838:7203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60121.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          110 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gatccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001640             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13217:6122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001640
VERSION     KCXD01001640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13217:6122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60122.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       439..451
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          108 c          157 g          118 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctg ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag caacggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagtgat atcgtttgat
      301 gaaagtaaga aatactatgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacttgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagactctta tggaagtggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001641             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15996:9217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001641
VERSION     KCXD01001641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15996:9217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60123.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          117 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaagtac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacattcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001642             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20423:20399
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001642
VERSION     KCXD01001642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20423:20399"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..455
     V_segment       103..388
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60124.1"
                     /translation="CMGGKRQLDLDYW"
     D_segment       405..411
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          133 c          128 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cggctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tttctggtga
      181 ctctatcagc acttacttct ggaactggat ccgccaggcc ccagggatgc gactggagtg
      241 gattggattt atctatggtt atgatagtag taccaactat aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaacaa ccaactctcc ctgaggctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtat gggcgggaag aggcaactgg atcttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001643             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14866:10586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001643
VERSION     KCXD01001643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14866:10586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..493
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60125.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       412..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          104 a          138 c          146 g          107 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtctcaggtc
      121 cagctggtgc agtccggggc tgagatggag aagcctgggg cctcagtgaa gctctcctgt
      181 aaggcttctg gatacacctt cagcatctat gtcatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg aggcatcttc cctcttgttg gtacaacaaa ctacgcacag
      301 aagttccagg gcagagtcac gattaccgcg gacacgtcca caagcacagc ctacatggac
      361 ctgagcagcc tgggatctgg ggacacggcc gtgtattatt gtgcgagagg ttactgtact
      421 ggtagtggtt gtaaccttac attcaaccgg ctcgatgtct ggggcccggg agtcccggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001644             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24386:11273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001644
VERSION     KCXD01001644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24386:11273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60126.1"
                     /translation="CARDDSGTGFDYW"
     D_segment       437..445
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          110 c          155 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatc
      121 ttaagaggtg tccagtgtga agtgcaactg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctatggcatg
      241 cactgggtcc gcctggctcc agggaagggg ctggagtggg tggcagttat gtcgaatgat
      301 ggaattaata agtactacgc agactctgtg aaggaccgat acaccatctc cagagacaat
      361 tcgaggaaca tgctgtatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tattgtgcga gagatgatag tgggaccggt tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001645             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24392:14051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001645
VERSION     KCXD01001645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24392:14051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60127.1"
                     /translation="CARWSAANFDYW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          137 c          134 g           99 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga agcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc aacagtggtt atggctggag ctgggtccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtgtctct atgatagtag tgggaacacg tactacaacc cctccctcaa
      301 gagtcgcgtc accatttcaa aagacacgtc caagaaccag ttctccctga acctgaggtc
      361 tatgaccgcc gcggacacgg ccgtctatta ctgtgcgaga tggtcggcag ccaactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001646             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22229:12069
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001646
VERSION     KCXD01001646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22229:12069"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60128.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       405..413
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           93 a          131 c          137 g          104 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccagggc tggtgaagcc tccggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tctatcagca gtagttactg gagctggatc cgccagaccc cagggaaggg actggagtgg
      241 attgggtata tccatgggag tgatagtagt accaagtaca acccctccct caagagtcga
      301 gtcaccctgt cagtagacac gtccaagaat caatgctccc tgaagctgag ctctgtgacc
      361 gccgcggaca cggccgtgta ttattgtgcg agttcgggta tagaagtggt tgcctacagt
      421 attgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001647             309 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:19251:17621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001647
VERSION     KCXD01001647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 309)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 309)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:19251:17621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..307
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..307
     V_segment       10..243
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <235..>276
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60129.1"
                     /translation="CARDTSFTGRYDYW"
     D_segment       246..250
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       267..307
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        308..>309
                     /gene="IGHG"
BASE COUNT           67 a           91 c           81 g           70 t
ORIGIN      
        1 acatgggcgt gcgctgtctc tggtggctcc atcagtatta gttataggtg gacctggatc
       61 cgccagcccc cagggaaggg actggagtgg attggataca tctatggtag tagtacgacc
      121 accaactaca acccctccct caaaagtcga gtcaccattt cacaagacac gtccaagaac
      181 cagttctcct tgaggctgaa ctctgtgacc gccgcggaca cggccgtata tttctgtgcg
      241 cgagatactt cctttaccgg ccggtatgac tactggggcc agggagtcct ggtcaccgtc
      301 tcctcagcc
//
LOCUS       KCXD01001648             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7981:11537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001648
VERSION     KCXD01001648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7981:11537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60130.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       440..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          112 a          121 c          164 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggtct gacctgggtt ttccttgttg
      121 gtcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggctc
      181 agcctggggg gtccctgaga ctctcctgtg cagcgtctgg gttcaccttc agtagctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gccatatcgt
      301 ttgatggaag taagaagaac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtactactg ttcgagggag tggatacagt gggcgcagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001649             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:7987:10255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001649
VERSION     KCXD01001649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:7987:10255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60131.1"
                     /translation="CARGIDNYHFSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          117 a          115 c          150 g          132 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgtgga gcagttggtg gaatctgggg gaggattggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct gaattcacct tcagtagcta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtctg gagtgggtat caggtattaa
      301 cattggcggt gacacattct acccagactc tgtgaagggt cgattcacta tctccagaga
      361 caatgccaag aactccgtgt atcttcaaat gaacagcctg agagttgagg acactgctgt
      421 gtatttttgt gcaaggggga tagataacta ccactttagt aatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001650             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18558:13809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001650
VERSION     KCXD01001650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18558:13809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60132.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       419..425
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          138 c          143 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaaa acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattattg tgcgagaggt
      421 gtgacagcag acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001651             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12020:11415
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001651
VERSION     KCXD01001651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12020:11415"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..466
     V_segment       85..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60133.1"
                     /translation="CAREYCSGIYCDWPSYALDSW"
     D_segment       385..405
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..466
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT          103 a          145 c          113 g          107 t
ORIGIN      
        1 acatgggggt gactcctgtg ccccaccatg gacacgcttt gctacacact cctgctactg
       61 accgtcccgt cctgggtctt gtcccaggtg accctgaaag agtctggtcc tgcgctggtg
      121 aaacccacac agaccctcac gctgacctgc tccttctctg ggttctcaat cagcacttct
      181 ggaacaggtg tggactggat ccgtcagccc ccagggaagg ccctggaatg gcttgcaacc
      241 atttattgga atgatagtaa atactacacc acatcgctga agaacaggct caccatctcc
      301 aaggacacct ccaaaaacca ggtggttcta agaattacca acatggaccc tatggacaca
      361 gccacgtact tctgtgcacg ggagtattgt agtggtattt actgcgactg gccctcctac
      421 gctttggatt cctggggcca aggggtcgtc gccaccgtct cctcagcc
//
LOCUS       KCXD01001652             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:8307:16450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001652
VERSION     KCXD01001652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:8307:16450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60134.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       436..443
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          141 c          138 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggttaagaag cctggggcct cagtgagggt
      181 ctcctgccag gtttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgatcct gtaaatggtg aaataataca
      301 cgcagacaac ttccagggca gagtcaccat gaccgaagac acgtctatag acacagccta
      361 catggaactg agcagcctga gatctgagga tacggccgta tattactgtg cgacccacgg
      421 aggctatagt gacatctgga actccctgta ctacggtttg gattcctggg gccaaggggt
      481 cttcgtcacc gtctcctcag tc
//
LOCUS       KCXD01001653             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10892:18651
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001653
VERSION     KCXD01001653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10892:18651"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..496
     V_segment       116..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60135.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       416..429
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>502
                     /gene="IGHG"
BASE COUNT          111 a          137 c          147 g          107 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc agtcccaggt
      121 ccacctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga agctctcctg
      181 caaggcttct ggatacacct tcagcatctc ttccatcagt tgggtgcgac aggcccctgg
      241 acaagggctt gggtggatag gagggatcat ccctcttgtt ggtatgacaa actacgaaca
      301 ggagttccag ggcagagtca cgattaccgc ggacacgtcc acgaatacag tcttcatgga
      361 actgagcagc ctgagatcgg aggacacggc cgtctactat tgtgcgacag gggtatatta
      421 ccaggatgaa aacggttatt tttatgtcgg cggggacttt gactactggg gccagggagt
      481 cctggtcacc gtctccccag cc
//
LOCUS       KCXD01001654             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:15650:8103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001654
VERSION     KCXD01001654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:15650:8103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60136.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          119 c          152 g          116 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttcg
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aagttggagg acacggccgt
      421 ctattactgt gcgagagacg catatggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001655             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18433:12168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001655
VERSION     KCXD01001655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18433:12168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60137.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          143 c          145 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaaatgaa gaagcctggg gcctcagtta
      181 gggtctcctg caaggtttcc ggaaacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgtcga tcctgcacaa ggtgaaataa
      301 tacacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 ccttcatgga gttgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgaaag
      421 gggggttcgg aaccagcgtc tggtccaacc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001656             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:25811:12601
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001656
VERSION     KCXD01001656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:25811:12601"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60138.1"
                     /translation="CVRYEDESINYHFDSW"
     D_segment       416..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          139 c          125 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gacttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aagatgaatc cattaactac
      421 cactttgact cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001657             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11134:19413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001657
VERSION     KCXD01001657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11134:19413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60139.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          117 c          154 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc aatacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgg
      301 gtgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tacgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001658             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18953:4717
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001658
VERSION     KCXD01001658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18953:4717"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60140.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       421..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          142 c          142 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat ccaccttcac cgaattatcc atacactggg tgcggcaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgctcct ctatatggtg aaatgatgct
      301 cgcagacaac ttccagggca gagtcacctt gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgacga cacggccgtg tattactgtg cgcgtgggcc
      421 tattacaatt tttggcgtac ttattacggg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001659             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14261:9953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001659
VERSION     KCXD01001659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14261:9953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..488
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60141.1"
                     /translation="CAREYCTSDSCAGFLDSW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>495
                     /gene="IGHG"
BASE COUNT          116 a          139 c          138 g          102 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc acttggtgca gtccggggct gaggtgaaga agcctgggac ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccctc gacaactatg gaatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccttgtcgg tatagtgaac
      301 tacgtagaga gcctccaggg cagaggcacg ataaccgcgg acacgtcaac aaacacggtc
      361 tacatggaac tgaacagcct gagatctgac gacacggcca tctattactg tgcgagagaa
      421 tactgtactt ctgattcttg cgccggattc cttgactcct ggggccaggg agtcctggtc
      481 accgtctctc cagcc
//
LOCUS       KCXD01001660             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14741:4193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001660
VERSION     KCXD01001660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14741:4193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60142.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          111 c          155 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca ggagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aagaaatatt acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001661             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19585:5641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001661
VERSION     KCXD01001661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19585:5641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60143.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgcgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacgtac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatttgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001662             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18413:7796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001662
VERSION     KCXD01001662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18413:7796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..498
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60144.1"
                     /translation="CARGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>502
                     /gene="IGHG"
BASE COUNT          115 a          140 c          149 g           98 t
ORIGIN      
        1 acatggggac cacacaacaa ccacatccct cgcctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaagtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 cgcctgcaag gtttccggaa acaccttcac cgaattattc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgtcgatcct gctcaaggtg aaataatata
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgagaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctctg cc
//
LOCUS       KCXD01001663             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13910:12046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001663
VERSION     KCXD01001663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13910:12046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..425
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60145.1"
                     /translation="CARGETASVYYGLDSS"
     D_segment       434..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          129 c          156 g          110 t
ORIGIN      
        1 acatgggggg agaggagccc agcactggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctggg ggcggcttgg caaagcctgg
      181 gggatccctg agactctcct gtgcagcctc tggattcacc ttcaatacct atgctataca
      241 ctgggtccgc caggctcccg ggaaggggct ggactgggtc tcagccatta gtagtggtgg
      301 gcgcacatac tacgcagact ccgtgaaggg ccgagtcacc atctccagag acaactcaaa
      361 gaacacggtc tccctgcaaa tgaacagcct gggagctgag gacacggccg tgttttactg
      421 tgcgagaggg gagacagctt cagtttacta cggtttggat tcctcgggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001664             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12644:7775
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001664
VERSION     KCXD01001664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12644:7775"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..482
     V_segment       125..412
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60146.1"
                     /translation="CTYRSSYYYGVESW"
     D_segment       415..419
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..482
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           99 a          140 c          136 g          109 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gtgcttcctt ttctgtcctc
       61 caccacgatg gggtcaactg ccatcctcac cctcctactg gctgttctcc aaggagtctg
      121 tgccgaggtg cagctggtgc agtctggagc agaggtgaaa aggcccgggg agtctctgaa
      181 gatctcctgt aggacttctg gatacaagtt cagcagctac tggatcaact gggtgcgcca
      241 gatgcccgga aaaggcctgg agtggatggg ggcgattgat cctagtgatt ctgagaccag
      301 atacagaccg tccttccaag gccaggtcac catctcagcc gacaagtcca tcagtaccgc
      361 ctacctgcag tggagcagcc tgaaggcctc ggactccgcc acgtattatt gtacataccg
      421 gtcttcatat tattacggtg tagagtcctg gggccaaggg gtcgtcgtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01001665             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19011:11007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001665
VERSION     KCXD01001665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19011:11007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60147.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       413..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           93 a          136 c          129 g          112 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtaac ttctggatct ggatccgcca gcccccaggg aaggggctgg
      241 agtggatagg gtctatctat ggtagtactg ggagcacctt ttacgacccc tccctcaagg
      301 gtcgagtcac catttcaaca gacacgtcca agaacctatt ttccctgaag ctggactctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgcgagata tagcgatact gatagttatt
      421 acttctttga ctactggggc cagggagtcc gggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001666             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24964:14630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001666
VERSION     KCXD01001666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24964:14630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60148.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       436..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          125 c          158 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca ggtggtggag tctggtggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 aatgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtctcag ccattagtgt
      301 tggtggtagt acatattacg caggctccgt gaggggccga ttcaccatct ccagagacaa
      361 ctcagagaac acgctctccc tgcaaatgaa cagcctgaga cctgaggaca cggccgtgta
      421 ttactgtgcg aaaggggata cagctacagt ttattacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001667             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21879:11437
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001667
VERSION     KCXD01001667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21879:11437"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60149.1"
                     /translation="CARGARSDYHSGYYTHFDYW"
     D_segment       428..446
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          105 a          139 c          142 g          105 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcgccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtggaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atataccttc agcatctttg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatgggg gggatcatcc ctcttgttga tatgacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccc tatattattg tgcgcgaggc gcccggtctg
      421 attatcatag tggttattac acccactttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001668             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:16203:19690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001668
VERSION     KCXD01001668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:16203:19690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60150.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          123 a          140 c          136 g           94 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaagtccaag gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 gtccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcgtca gcc
//
LOCUS       KCXD01001669             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:26167:11774
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001669
VERSION     KCXD01001669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:26167:11774"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60151.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          114 c          155 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttcg gaacctatgg
      241 catgcactgg gtccgccagg ctccagggat gggcctggag tgggtgacgg ttatatcgaa
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcagca tctccagaga
      361 caattccaag aacatgctat atcttcaaat aaacaacgtg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cgtttggtag cgggcttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001670             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19335:12815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001670
VERSION     KCXD01001670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19335:12815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60152.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       405..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           94 a          138 c          138 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacatgcgc tgtctctgga
      181 ggctctgtca gcagtagcac ctggtggaac tggatccgcc agcccccagg gaaaggactg
      241 gaatggattg gctatatcag tggtgatagt ggtaggaact cctacaaccc ctccctcaag
      301 agtcgaatca ccatttcaac agacacgtcc aagaaccagt tctccctgag gctggggtct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag gttcctatag tggcagttat
      421 tacttcaacc ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001671             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10812:9627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001671
VERSION     KCXD01001671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10812:9627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..327
     V_segment       8..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60153.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       257..263
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..327
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>331
                     /gene="IGHG"
BASE COUNT           79 a           89 c           88 g           75 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caaggtttcc ggctacacct tcgccgaatt
       61 gcccatacac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaggttttgc
      121 ttctatatat ggtgaaataa tacatacaga gagattccag ggcagagtca ccatgacagc
      181 ggacacgtct atagacacag cctacatgga actcagcagc ctgacatctg aggacacggc
      241 cgtgtattac tgtgcggcag ctgatagtgg ttacccattt tactacttcg atatctgggg
      301 ccctggcacc ccaatcacca tctcctccgc c
//
LOCUS       KCXD01001672             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10059:19595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001672
VERSION     KCXD01001672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10059:19595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60154.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       424..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          117 a          144 c          133 g           99 t
ORIGIN      
        1 acatggggaa catcacacaa caaccacatc cctcccctac agaagcccca gagcgcagca
       61 cctcaccatg gactggacct ggaggatcct cctcttagtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc aatctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt cagcgattta tccatacact ggatacgaca
      241 ggcccctgga aaagggcttc agtggatggg aagtgttgat cctgcttttg gtgaaatgat
      301 aaacgcagag aagttccagg gcagagtcac catgaccgag gacacgtctt cagacacagc
      361 cttcatggaa ttgagcagcc tgaaatctga cgacacggcc gtgtatttct gtgcgagtgg
      421 ccctagcggc acctggatcg actggtcctt cgatgtctgg ggccctggca ccccaatcac
      481 cgtctcctca acc
//
LOCUS       KCXD01001673             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6972:10196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001673
VERSION     KCXD01001673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6972:10196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..518
     V_segment       143..434
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60155.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       454..465
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..518
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          112 a          123 c          161 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtattt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca cctggtgcag tctgggggcg gcttgacaaa
      181 gcctgggggg tccctgagac tctcctgtgc ggcctccgga ttcaccttca gtgactacta
      241 tatggactgg gtccgccagg ctccagggaa ggggctggag tgggtctcac gaatcagtca
      301 tgatggtgat agcacatggt acgcagactc cgtgaagggc agatttacca tttccagaga
      361 gaatgccaag aacacactgt ttcttcaaat ggacagcctg agaagtgagg acacagccgt
      421 atattactgt gcgagagagc gttttggggg aattggggtg attatcttca actggatcga
      481 tgtctggggc ccgggagtcc tggtcaccgt cccctcagcc
//
LOCUS       KCXD01001674             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9884:9961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001674
VERSION     KCXD01001674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9884:9961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60156.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       415..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          115 a          146 c          134 g           94 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc atagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagcaacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gaattatcca ttcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggc gttgatcctg catatggtga gtttacaccc
      301 ggagagaagc tccagggcag agtcaccatg accgaagaca cgtctataga cacagcctac
      361 atggagctga gcagcctgaa ttctgacgac acggccgtct attactgtgc tgccgggtat
      421 agcggcagct ggaaccactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01001675             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13740:10375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001675
VERSION     KCXD01001675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13740:10375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60157.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       439..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          118 c          149 g          120 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg ctgacagtta tatcgtatga
      301 tgaaactaag aaatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atggtgtatc ttcaaatgaa caacctgaca tttgaggacg cggccgtgta
      421 ttactgtgcg agagattctt acggtcgagg ctttgattcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001676             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:24740:9838
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001676
VERSION     KCXD01001676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:24740:9838"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60158.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       421..427
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          138 c          144 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tactgtatct gatggagtga
      301 tatacgcaga aaacttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattat tgtgcgagag
      421 gtgtgacagc agacgtcttc ggtttcctcg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001677             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:25585:15406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001677
VERSION     KCXD01001677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:25585:15406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60159.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          113 c          155 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagcctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc tatggcatgc
      241 actgggtccg ccaggctcca gggatgggcc tggagtgggt gacggttata tcgaatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acgtgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001678             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16448:6318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001678
VERSION     KCXD01001678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16448:6318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..511
     V_segment       136..435
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60160.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       438..444
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..511
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          122 c          155 g          121 t
ORIGIN      
        1 acatgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt gatcagcact
       61 gaacacaaga gactcaccat ggagtttgta ctgagctggg ttttccttgt tgctatttta
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt ccagcctggc
      181 gggtccctga gactctcctg tgtaggctct ggattcacct tcagtgacta tgccatgagc
      241 tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag aagcaaatct
      301 tacaattacg cggcagaata cgccgcatcg gtgaaaggca ggttcaccgt ctccagagat
      361 gattcaaaga acacgctaca tctgcaaatg agcagcctga aaaccgagga cacggccgtg
      421 tattactgtg ctagagggga tataccggct atagaggcct actacggttt ggattcctgg
      481 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001679             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26069:18539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001679
VERSION     KCXD01001679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26069:18539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60161.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..410
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           86 a          136 c          139 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga cttgtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggggctggat ccgccagccc ccaggggagg ggctggagtg
      241 gattgggtat atcagtggga gtggtgggag taccgactac aagtcctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001680             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:8532:20896
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001680
VERSION     KCXD01001680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:8532:20896"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60162.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          157 g          115 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggcg gttatagcca
      301 atgatggaac taagaaatac tacgcagact ctgtgaagga ccgattcagc atttccagag
      361 acaactccaa gaacatactg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctactactg tgcgacagat gcgtttggta gcgggattga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001681             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:13446:18540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001681
VERSION     KCXD01001681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:13446:18540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60163.1"
                     /translation="CARDKGYSAVRRFDVW"
     D_segment       404..410
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          143 c          133 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc agtaactcct ggaactggat ccgccagccc ccaggggagg gactggagtg
      241 gattggacgt atctctagtc ttagtgggag caccaactac aacccctccc tcacaagtcg
      301 agtcaccatt tcaacagaca cgtccaagat ccagatctcc ctgaggctaa gttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagataag ggttacagtg cagttcgacg
      421 gttcgatgtc tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001682             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18291:8115
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001682
VERSION     KCXD01001682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18291:8115"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60164.1"
                     /translation="CARGVDNHHYSETEFDFW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          114 a          119 c          151 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggga ttcccaggtg ttttcattca gagatcagga
       61 ctgaacacac aggactcacc atggagttta tgctgagctg ggttttcctt gttgctatat
      121 taaaaggtgt ccagtgtgtg gagcagctgg tggagtctgg gggaggcttg gtacagccgg
      181 gggcgtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatgacatgc
      241 actgggttcg ccaggctcca gggaagggtc tggagtggat atcaggtatt aacattggcg
      301 gtgacacata ctacccagac tctgtgaagg gtcggttcac catctccaga gacaatgcca
      361 agaactcctt gtatcttcaa atgaacagcc tgagagctga ggacactgct gtgtattatt
      421 gtgcaagagg cgtagataac caccactaca gtgagacgga gtttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001683             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14727:8628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001683
VERSION     KCXD01001683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14727:8628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..514
     V_segment       139..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60165.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       441..447
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          116 a          124 c          158 g          118 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattcccagg cgtctccact tggtgatcag
       61 cactgaacac aagagactca ccatggagtt tgcactgagc tgggttttcg ttgttgctac
      121 ttaaaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggcgggtccc tgagactctc ctgtgcaggc tctggattca ccttcagtga ctatgccatg
      241 agctgggtcc gccaggcttc tgggaaagga ctggagtggg ttggctatat tagaagcaaa
      301 tcttacaatt acgcgacaga atacgccgca tcggtgaaag gcaggttcac catctccaga
      361 gatgattcaa agtacacgct acatctgcaa atgagcagcc tgaaaaccga ggacacggcc
      421 gtgtattact gtgctagagg ggatataccg gctatagagg cctactacgg tttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001684             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5289:10037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001684
VERSION     KCXD01001684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5289:10037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60166.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       437..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..501
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          108 a          133 c          149 g          113 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcgaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcaat acctatgcta
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcaggt attagtagtg
      301 gtggtaccac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgacaac tgaggacacg gccgtatatt
      421 actgtgcgaa gggaggtagc agctctttct actggtactt cgatatccgg ggccctggca
      481 ccccagtcac catctcctca gcc
//
LOCUS       KCXD01001685             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:9430:15012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001685
VERSION     KCXD01001685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:9430:15012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..495
     V_segment       120..419
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60167.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       422..428
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          118 c          148 g          119 t
ORIGIN      
        1 acatgggggg gattcccagg cgtctccact tggtgatcag cactgaacac aagagactca
       61 ccatggagtt tgtactgagc tgggttttcc ttgttgctat tttaaaaggt gtccagtgtg
      121 aggtgcagct ggtggagtct gggggaggct tggtccagcc tggcgggtcc ctgagactct
      181 cctgtgcagg ctctggattc accttcagtg actatgccat gagctgggtc cgccaggctt
      241 ctgggaaagg actggagtgg gttggctata ttagaagcaa atcttacaat tacgcgacag
      301 aatacgccgc atcggtgaaa ggcaggttca ccatctccag agatgattca aagaacaccc
      361 tacatctgca aatgagcagc ctgaaaatcg aggacacggc cgtgtattac tgtgctagag
      421 gggatatacc ggctatagag gcctactacg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001686             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20140:12517
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001686
VERSION     KCXD01001686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20140:12517"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60168.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          149 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag agatgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagttatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 ctgatgaaag taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001687             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16854:16912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001687
VERSION     KCXD01001687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16854:16912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..461
     V_segment       92..385
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60169.1"
                     /translation="CAREYCTTHDCAGFFDYW"
     D_segment       386..397
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           99 a          123 c          138 g          103 t
ORIGIN      
        1 acatgggggg cccctgggag cacagctcat caccatggac tggacctgga ggctcctctt
       61 tgtggtggca gcagctacag gtgtccagtc ccaggtccag ttggtgcagt ccggggctga
      121 ggtcaagaag cctggggccg cagtgaaggt ttcctgcaag gcttctggat tcaccctcga
      181 caactatggt atcaactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggagt
      241 gatcatcccc catgttggta taataaatta cggtgagcgg ttccaggaca gagtcacgat
      301 tagcgcggac acgtccatga atatagccta catggacctg accagcctga aatccgacga
      361 cacggccatc tatttctgtg cgagagaata ctgtactact catgattgcg ccggcttctt
      421 tgactactgg ggccagggag tcctggtcac cgtctcttca gcc
//
LOCUS       KCXD01001688             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14073:15990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001688
VERSION     KCXD01001688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14073:15990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..449
     V_segment       95..388
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60170.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       398..403
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..449
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT          106 a           99 c          136 g          110 t
ORIGIN      
        1 acatggggtg atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt
       61 tttccttgtt gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg
      121 aggcttggtt cagcctgggg ggtccctgag actctcctgt gtagcctctg gattcacctt
      181 cagtacctat ggcatacact gggtccgcca gactccaggg aaggggctgg agtgggtggc
      241 agttatatcg tatgatgaaa ctaagaagta ctacgcagac tctgtgaggg accgattcac
      301 catctccaga gacaattcca aaaacatggt ctatcttcaa atgaacaacc tgaagttgga
      361 ggacacggcc atatattact gtgttagaga tgtcagggga acggggtttg actactgggg
      421 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001689             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:25706:5969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001689
VERSION     KCXD01001689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:25706:5969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..346
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60171.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       352..358
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..410
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           90 a           98 c          122 g          102 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcatct tcagtaacta tgccatgcac tgggtccgcc aggctccagg
      181 gaaggggcta gagtgggtgg cagttatttc gcatgatgga actaagaaat actacacaga
      241 ctctgcgaag gaccgattca ccatctccag agacaattcc aagaacatac aatatcttca
      301 catgaacagc ctgaaattgg aggacacggc catatactac tgtgcggcct cctacttggg
      361 gtacggtttt gagtactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001690             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12481:4066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001690
VERSION     KCXD01001690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12481:4066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60172.1"
                     /translation="CARYDEDDYGYYYLDYW"
     D_segment       401..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           94 a          140 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccagtagctt ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ctatctatgg tgctactggg agcaccacct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt atattactgt gcgagatatg acgaggatga ttacggttac
      421 tattaccttg actactgggg ccagggagtc ctggtccccg tctcatcagc c
//
LOCUS       KCXD01001691             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20607:19915
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001691
VERSION     KCXD01001691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20607:19915"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60173.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       419..430
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          108 a          139 c          139 g           95 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaagaacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgaatatg gtgaaatgat
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggagct
      361 gagcagcctg agatctgagg acacggccgt ctattactgt gcgattggcc ctagtggcag
      421 ctggaacgac tggtccttcg acatttgggg acctggcacc ccaatcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01001692             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12146:8816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001692
VERSION     KCXD01001692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12146:8816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60174.1"
                     /translation="CARGLPTVFGVVITDVW"
     D_segment       415..426
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..467
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          137 c          136 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagacg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcactg tctctggtga
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggcat atcagtgtta gtcttgggaa gaccgactac aacccgtccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaaggtga actctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagaggactt cctacagttt ttggagtggt
      421 tattacggat gtctggggcc cgggagtcct ggtcatcgtc tcctcagcc
//
LOCUS       KCXD01001693             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12020:9936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001693
VERSION     KCXD01001693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12020:9936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60175.1"
                     /translation="CAREWIQWVQLVSGFDAW"
     D_segment       441..462
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          118 a          116 c          161 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagacg actcaccatg aagtttgggc tgaactgggc tttccttgtt
      121 gttattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggcgg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtagctat
      241 gccatacact gggtccgcca ggctcctggg aaggggctgg agtgggtggc agtcatatcg
      301 tatgatggaa gtaagaaata ctatacagac tctgtgaagg accgattcac tatcaccaga
      361 gacaattcca acaacatagt atatcttcaa atgaacgacc cgaaattgga ggacacggcc
      421 gtgtattact gtgcgaggga gtggatacag tgggtacagt tagtgagcgg tttcgatgcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001694             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10574:4496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001694
VERSION     KCXD01001694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10574:4496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60176.1"
                     /translation="CAREGISASGVDYW"
     D_segment       401..407
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           83 a          135 c          146 g          100 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca catgggtcct gtcccaggtg caacttcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtccccaggg aaggggctgg
      241 agtggattgg gtttttcggt ggtcgcaatg ggaacacgta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcacca gacacgtcca aagagcagtt ctccctgagg ctgaggtctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgaggga ggggatatca gcgtcggggg
      421 tcgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001695             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10600:3173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001695
VERSION     KCXD01001695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10600:3173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60177.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       442..446
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          137 c          143 g          101 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacaccttca gcgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa aggacttgag tggatgggag gtgttgatac tgtatctgat ggagtgatat
      301 acgcagagaa cctccagggc agagtcgcca tgaccgagga cacgtctaca gacacagcct
      361 acatggaatt gagcagcctg agatctgagg acacggccgt ttattactgt gcgagaggtt
      421 tatcaccaga cgtcttcggt ttcctcgggc ttggctactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001696             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16746:15142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001696
VERSION     KCXD01001696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16746:15142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60178.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          124 c          157 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac aaaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaggttca gtttctacta
      241 catgagctgg gtccgccagc ctccagggaa gggtctggag tggatctcag gtattaacgc
      301 tggtggggat ggcacatact ctgcagactc cgtgaagggc agatttacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001697             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14963:13801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001697
VERSION     KCXD01001697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14963:13801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60179.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       399..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           99 a          135 c          138 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
      121 gggcccagga ctgatgaagc cttcagagac cctgtccctc agctgcgctg tctctggtgg
      181 ctccataagt ggtaactggt ggagctggat ccgccagccc ccagggaagg gactggactg
      241 gattggacgt atctctggta ctagtgggga caccaattac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga actctgtgac
      361 cgccgcggac gcggccgtgt attattgtgc aagagcggat tacgaggatg attacggtta
      421 tcatttagga tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01001698             411 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20621:16831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001698
VERSION     KCXD01001698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 411)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 411)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20621:16831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    46..409
                     /note="immunoglobulin heavy chain variable region"
     V_region        46..409
     V_segment       46..339
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <331..>378
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60180.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       349..355
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..409
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        410..>411
                     /gene="IGHG"
BASE COUNT           88 a           94 c          128 g          101 t
ORIGIN      
        1 acatgggggg ttttccttgt tgctcttttg aaaggtgtcc agtgtgaggt gaagctggtg
       61 gagtctgggg gcggcttggc aaagcctggg gggtccctga gactctcctg cgcagcctct
      121 ggattcagct tcaattatta ctatatgagt tgggtccgcc aggctccagg gaaggggctg
      181 gagtggatct caggtattaa tagtggtggg gaaagcacat actctgcaga ctccgtgaag
      241 ggcagattca ccatctccag agagaacgcc aagaaaacag tatatcttca aatggacagc
      301 ctgagaactg aggacacggc tgtctattac tgtgtgagag atcgacgtgt acagtcctta
      361 tcctggttcg atgtctgggg cccgggagcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001699             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:3815:13744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001699
VERSION     KCXD01001699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:3815:13744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..347
     V_segment       7..271
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <263..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60181.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       277..296
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..347
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>349
                     /gene="IGHG"
BASE COUNT           70 a          100 c           98 g           81 t
ORIGIN      
        1 acatggggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg gtggctccat
       61 cagcagtagt acctggtgga actgggtccg ccagccccca gggaaaggcc tggagtggat
      121 aggatatatc aatggtgaga gtggtagcac ctactacaat ccctccctcg agagtcgaat
      181 caccatttca acagacacgt ccacgaacca gttttccctg aggctgagct ctgtgaccgc
      241 cgcggacacg gccgtgtatt tctgtgcgag aggttcctat agtggtagtt attacttcaa
      301 ccggttcgat gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001700             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23745:10427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001700
VERSION     KCXD01001700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23745:10427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60182.1"
                     /translation="CARAVGGAAGYFDFW"
     D_segment       432..439
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          124 c          152 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgaa
      241 ctgggtccgc cagactccag gcaaggggct ggaatggatc tcaggtatta acactggtgg
      301 cattaacaca tactatgcgg actccgtgaa gggcagattc accatctcca gagaggacgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gcagtgggtg gtgccgcagg atacttcgat ttctggggcc tgggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001701             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8748:8056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001701
VERSION     KCXD01001701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8748:8056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60183.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          111 c          155 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtata tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtcagttata tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 caaaaaacat ggtttatctt caaatgaaca acctgaagtt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001702             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16525:20035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001702
VERSION     KCXD01001702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16525:20035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60184.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          115 c          151 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtggctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtctct gagactctcc tgtgcagtct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaactt ggaggacacg gccgtctatt
      421 actgtgcgag ggacgcattt ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001703             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16579:11118
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001703
VERSION     KCXD01001703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16579:11118"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60185.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 cggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001704             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12495:9153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001704
VERSION     KCXD01001704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12495:9153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60186.1"
                     /translation="CAIGPTGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          144 c          135 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgatg
      181 gtctcctgca aggtttccgg acacaccttc accgaattgt ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgaag
      301 ttccaggcca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgtg tattactgtg cgattggccc taccggcagg
      421 tggaacgact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001705             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16312:4619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001705
VERSION     KCXD01001705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16312:4619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..505
     V_segment       126..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60187.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       427..452
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>509
                     /gene="IGHG"
BASE COUNT          120 a          140 c          144 g          105 t
ORIGIN      
        1 acatggggac atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 agctctcctg caaggcttct ggattcacgt tcagcaccga tgccatcagt tgggtgcgac
      241 aggcccctgg acaagggctt gattggatgg gaggggtcat ccctcttatg ggtacaacaa
      301 actacgcaca gaagttccag ggcagagtca cgtttaccgc ggacacgtca ctaagcacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtattat tgtgcgaaat
      421 ccgtgaatta cgaggaagat aacggttact atataccgac gcagtttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctctgcc
//
LOCUS       KCXD01001706             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14777:6162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001706
VERSION     KCXD01001706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14777:6162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60188.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          115 c          149 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgcccag tgtgaggtac aattggtgga gtctggagga ggtttgggtc
      181 agcctggggg gtccctgaga ctctcctgtg aaacttctgg attcaccttc agtaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 atgatgtaag taagacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattctaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001707             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19087:14680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001707
VERSION     KCXD01001707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19087:14680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..451
     V_segment       94..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60189.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       393..402
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           81 a          136 c          136 g          100 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctccttgtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga gtggattggc
      241 tttttcggtg gtagtggtgg gagcacctac tacaagtcct ccctccagag tcgagtcacc
      301 atttcaaccg acacgtccaa gaaccagttc tccctgatac tgacctctgt gaccgccgcg
      361 gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat tgactactgg
      421 ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001708             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24019:13800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001708
VERSION     KCXD01001708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24019:13800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60190.1"
                     /translation="CATSSSCTWLYWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          141 c          134 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagctgca cctggctata ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001709             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12722:8689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001709
VERSION     KCXD01001709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12722:8689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60191.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          110 a          145 c          134 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaaggccttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctgca gacacagcct acatggacct
      361 gagtagcctg acatctgagg acacggccgt gtattactgt gcgactggcc ctagcggcac
      421 ctggaacgcc tggtacctcg atatctgggg ccctggcact ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01001710             304 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:26227:12205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001710
VERSION     KCXD01001710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 304)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 304)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:26227:12205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..302
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..302
     V_segment       8..225
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>271
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60192.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       229..250
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       256..302
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        303..>304
                     /gene="IGHG"
BASE COUNT           77 a           73 c           90 g           64 t
ORIGIN      
        1 acatgggggg ttcaccttca gtagctatgc catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggcag ccatatcatt tgatggaagt aagaaaaact acgcagactc
      121 tgtgaaggac cgattcacca tctccagaga caactccaag aacatgctat atcttcaaat
      181 gaacaacctg aaactggagg acacggccgt gtactactgt tcgagggagt ggatacagtg
      241 ggcacagtta gtgagcggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc
      301 agcc
//
LOCUS       KCXD01001711             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21221:11551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001711
VERSION     KCXD01001711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21221:11551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..506
     V_segment       134..424
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60193.1"
                     /translation="CTRIGVGSLATAGEYFDYW"
     D_segment       444..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          128 c          155 g          120 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgc agctgatgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagga acactggtac
      301 acccgtatac tacgctgact ccgtgaaggg ccgattcacc atctccagag acaacgccaa
      361 gaactcactg tctctgcaaa tgagtagcct gagagccgag gacacggccg tgtattactg
      421 tactcggatt ggcgtcggat ctctagcaac ggctggtgaa tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001712             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18415:12413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001712
VERSION     KCXD01001712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18415:12413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60194.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          120 c          147 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg attcatgttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001713             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:25611:9212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001713
VERSION     KCXD01001713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:25611:9212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60195.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       289..293
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           76 a           86 c          105 g           83 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctgggga gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agtacctctg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtgtct gtaatttcgt ctgatggaag taagaaatac tacgcagact
      181 ctgtgaagga ccgattcacc atctccagag acaactccaa gaacacacta tattttcaaa
      241 tgaacaacct gaaattggag gacacggccg tgtatttctg tgtgagagat gccttcgggg
      301 gcggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001714             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22804:5386
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001714
VERSION     KCXD01001714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22804:5386"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..470
     V_segment       107..400
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60196.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       404..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           99 a          138 c          127 g          108 t
ORIGIN      
        1 acatgggggg aaatgctctc tgagagtcat ggacctcctg tgcaagaaca tgaagcacct
       61 gtggttcttc cttctcctgg tggcagttcc cagatgggtc ctgtcccagg tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc
      181 tggtgactcc atcaccaata gctactggaa ctggatccgc cagcccccag ggaagggact
      241 ggagtggatt ggatatatct ctggtgctta tgggagcacc agctacaacc cctccctcaa
      301 gagtcgagtc accatttcaa cagacacgtc caagaaccac ttttccctga ggctgagttc
      361 tgtgaccgcc gcggacaccg ccgtgtatta ctgtgtgaga tatgaggatg aatccattaa
      421 ctaccacttt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001715             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15922:16800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001715
VERSION     KCXD01001715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15922:16800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60197.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..448
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccactgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaagtt ggacgacacg gccgtctatt
      421 actgtgcgag agacgcattt ggcagcggtt gtgactactg gggccggggc gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001716             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23324:7716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001716
VERSION     KCXD01001716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23324:7716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..503
     V_segment       123..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60198.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       423..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>509
                     /gene="IGHG"
BASE COUNT          114 a          139 c          146 g          110 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca cctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgcaa gacttctgga tacaccttca gcatctctgc catcagttgg gtgcgacagg
      241 cccctggaca agggcttggg tggatgggag ggatcatccc tcttgttggt gtgacaaact
      301 acgaacagaa gttccagggc agagtcacga ttaccgcgga cacgtccacg aatacagtct
      361 tcatggaact gagcagcctg agatctgagg acacggccgt ctactattgt gcgacagggg
      421 tatattacca ggatgaatac ggttattttt atgtcggcgg tgactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tccccagcc
//
LOCUS       KCXD01001717             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:23502:4665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001717
VERSION     KCXD01001717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:23502:4665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60199.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          122 c          156 g          129 t
ORIGIN      
        1 acatggggag ctctgagaca ggagtcttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtggagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgtagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagaaacac
      301 tggtaaaatc gtatactacg ctgactccgt gaagggccga ttcatcatct ccagagacaa
      361 cgccaagaat tcgctgtttc tgcaaatgag cagcctgaga gtcgaggact cggccgtcta
      421 ttactgtact agaattggcg tcggatctct agcaccggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001718             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23884:7425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001718
VERSION     KCXD01001718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23884:7425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60200.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       412..416
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           93 a          138 c          131 g          102 t
ORIGIN      
        1 acatggggaa aggttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggcgccat cagcagtggt ttctactgga cctggatccg ccaaccccca gggaaggggc
      241 tggagtggat tgggtgtatc ggtggtagta gtggtaccac ctactacaac ccctccctca
      301 agagtcgagc caccatttca aaagacacgt ccaagaatca actctccctg aagctgagtt
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgccag agatgaagac ccctccattt
      421 ttgactattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001719             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8917:5656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001719
VERSION     KCXD01001719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8917:5656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..434
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60201.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       435..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          123 c          159 g          115 t
ORIGIN      
        1 atggggagct ctgggagagg agcccagccc cagaattccc aggtgtttct gttcggcgat
       61 cagcactcaa cacagaacat accatggagt atgtgctgag ttgggttttc cttgttgctc
      121 ttttgaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgcgcag cctctggatt caacttcaat tactactaca
      241 tgaactgggt ccgccaggct ccagggaagg ggctggagtg gatctcaggt attaacagtg
      301 gtggggatag cacatactat gcggactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaagaa cacactgtat cttcaaatgg acagcctgag agctgaggac acggctgtct
      421 attactgtgc gagagtggtg ggtggtgccg caggatactt cgacttctgg ggccagggcg
      481 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001720             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17319:10033
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001720
VERSION     KCXD01001720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17319:10033"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..486
     V_segment       117..410
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60202.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       425..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          113 a          140 c          139 g           96 t
ORIGIN      
        1 acatggggac ccaacaacag cacccctcca cagaagcccc tggatcacag ctccttgcca
       61 tggactggac ctggaggatc ctcttcttgg tggcagcagc aacaggtgcc cactcccagg
      121 tgcagctggt gcagtcgggg gctgaggtga agcagccggg gacatcagtg aaggtctcct
      181 gcaaggcttc tggctacacc ttcactagct atggtatgaa ctgggtgcga caggcccagg
      241 gacaacggct tgagtggatg ggatggctca acaccgacac tgggaaccca acgtatgccc
      301 agggcttcaa agaacgattt acattctcca tggacacctc tatgaccacg gcatatctgc
      361 agatcagcag cctaaagact gaggacacgg ccgtatacta ctgtgcaaga agtttgggct
      421 ggcatgatta taatgacgtc gcccttgact tctggggcca gggagtcctg gtcgccgtct
      481 cctcagcc
//
LOCUS       KCXD01001721             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12863:10871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001721
VERSION     KCXD01001721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12863:10871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60203.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       445..453
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          114 c          156 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccac acggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctt
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgaggctc tcctgtgcag cctctggatt caccttcagt cactatggcg
      241 ttcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaaataa gaaatactac gcagactctg tgagggaccg attcaccatc tccagagaca
      361 attccaagac catggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgt gagagatgtc agaggcggtg gctttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001722             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9049:14260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001722
VERSION     KCXD01001722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9049:14260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60204.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       414..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          142 c          138 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtct ttctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccctc accgaagtgt ccactcactg ggtgcgacag
      241 gccccgggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtccacag acacagccta catggaattg
      361 agcagcctaa gatctgagga cacggccgtg tattactgtg cgattggacc taccggcagg
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001723             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14259:14864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001723
VERSION     KCXD01001723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14259:14864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60205.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          122 a          143 c          134 g           96 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaaccctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      301 atagacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacttgg agctgagcag tctgagatct gaggacacgg ccgtgtatta ctgtgcgacc
      421 tcatccagcg gcacctggct atactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01001724             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7775:17379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001724
VERSION     KCXD01001724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7775:17379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60206.1"
                     /translation="CARGETTSVYYGLDSW"
     D_segment       435..439
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          130 c          155 g          108 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcaatacc tatgctatac
      241 actgggtccg ccaggctccc gggaaggggc tggactgggt ctcagccatt agtagtgctg
      301 ggcgcacata ctacgcagac tccgtgaagg gccgagtcac catctccaga gacaactcaa
      361 agaacacggt ctccctgcaa atgaacagcc tgggaactga ggacacggcc gtgtattact
      421 gtgcgagagg ggagacaacc tcagtttact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001725             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11296:17477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001725
VERSION     KCXD01001725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11296:17477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60207.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          117 a          140 c          149 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gagacacctt cagtgaaatg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gggaaataat
      301 acacgcagat aacttccagg gcagagtcac catgaccgag gacacgtcta tagacacagc
      361 ctacatggag ctgagtagcc tgagatctga ggacacggcc gtatattact gtgcgagcgg
      421 gacatttggg accagcgtct ggtccagcct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc agcgtctcct cagcc
//
LOCUS       KCXD01001726             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21201:16994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001726
VERSION     KCXD01001726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21201:16994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..478
     V_segment       127..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60208.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       410..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          116 a          136 c          136 g           92 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcagag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctgat gcagtccggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggttac cggatacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaaggact tgagtggatg ggaagtgttg atcctgtata tggtgaaatg
      301 aacgagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agtagcctga gatctgagga tacggccgtg tattattgtg cagtcggcaa tagcggcagc
      421 tggatctcct ggtccttcga tgtctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01001727             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13190:16655
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001727
VERSION     KCXD01001727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13190:16655"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60209.1"
                     /translation="CSTGHSGRWINWKFEIW"
     D_segment       421..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          125 a          137 c          134 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa gatttccgga tacaccttca ccgatttatc catacactgg gtgcgacagg
      241 cccctggaaa aggacttgag tggatgggaa gtgttgatcc tgcttatggt gaaatgataa
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acttggagtt gggcagcctg aaatctgagg acacggccgt gtattactgt tcaacaggcc
      421 atagcggcag gtggattaac tggaagttcg aaatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001728             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:16783:8169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001728
VERSION     KCXD01001728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:16783:8169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..500
     V_segment       134..419
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60210.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       435..442
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          119 c          141 g          127 t
ORIGIN      
        1 atggggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga tcaggactga
       61 acacacagga ctcaccatgg agtttatgct gaactgggtt ttccttgttt ctatattaaa
      121 aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac agcctggggc
      181 gtccctgaag ctctcctgtg cagcctctga gttcaccttc agtgactatg acatgcactg
      241 ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca ttggcggtga
      301 cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca acgccaagaa
      361 ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt attattgtgt
      421 gagggggatg gataactacc acttcagtaa tacggacttt gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001729             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12716:7515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001729
VERSION     KCXD01001729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12716:7515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    151..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        151..523
     V_segment       151..444
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60211.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       461..474
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          110 a          123 c          161 g          131 t
ORIGIN      
        1 acatggggca gagtacatgg ggtctgagac aggagtctta gccctggatt ccaagaactt
       61 ccactttggg atcagctctg aacacagagg accatggagt tggggctgag ctgggttttc
      121 cttgttgcta ttttaaaagg tgtccagtgt gaggtggagc tggtggagtc tgggggaggc
      181 ttggtccagc ctggggggtc cctgagactc tcctgtgtag cctctggatt cacctttggt
      241 gattatggca tgcactgggt ccgccaggct ccgggaaagg gactggagtg ggtctcatcc
      301 attagaaaca ctggtaaaat cgtatactac gctgactccg tgaagggccg attcatcatc
      361 tccagagaca acgccaagaa ttcgctgttt ctgcaaatga gcagcctgag agtcgaggac
      421 tcggccgtct attactgtac tagaattggc gtcggatctc tagcaccggc tggtgaatac
      481 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001730             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9637:18290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001730
VERSION     KCXD01001730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9637:18290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60212.1"
                     /translation="CARAGYSGSESFYGLDIW"
     D_segment       403..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          139 c          135 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gctcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gtctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaacta ctggagctgg atccgccagc cccccgggaa gggactggaa
      241 tggattggac gtttctctgg tagtggtgga aacaccgact acaacccctc cctcaagact
      301 cgagtcacct tttcaacaga cacgtccacg aaccagtttt ccctgaggct gaaatctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagccg gatatagcgg cagcgaaagt
      421 ttctacggtt tggatatttg gggccaaggg gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01001731             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:25693:18215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001731
VERSION     KCXD01001731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:25693:18215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60213.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       443..450
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          115 c          160 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtacaactg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca ccttcagtac ctttggcatg
      241 cactgggtcc gccaggctcc agggaaggga ctggagtggg tggcacttat atcgtatgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccctctc cagagacaac
      361 tccgagaaca tcctatatct tcaaatgaac aacgtgaaaa tggaggacac ggccgtgtat
      421 ttctgtgcga gagttggaga ggggactggt ggtgcggagg actttgactt ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001732             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23100:19272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001732
VERSION     KCXD01001732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23100:19272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..441
     V_segment       78..371
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60214.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       381..387
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..441
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           96 a          105 c          135 g          107 t
ORIGIN      
        1 acatgggcac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
       61 tgaaaggtgt ccagtgtgag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg
      121 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcaattat tactacatga
      181 gctgggtccg ccaggcccca gggaaggggc tggagtggat ctcaggtatt aatcatggtg
      241 gggaaagtac atactatgca gactccgtga agggcagatt caccctctcc agagagaacg
      301 ccaagaacac actatatctt caaatggaca gcctgagaac tgaggacacg gctgtctatt
      361 actgtgtgag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      421 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001733             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8479:7034
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001733
VERSION     KCXD01001733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8479:7034"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..498
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60215.1"
                     /translation="CATADYGNSLDYW"
     D_segment       442..453
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>501
                     /gene="IGHG"
BASE COUNT          111 a          121 c          149 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa gtatgaaata ctacgcagac tctatgaagg accgcttcac catctccaga
      361 gacaattcca agaacatact atatcttcaa atgaagaccc tgaaattgga ggacactgcc
      421 gtttattact gtgcgacagc cgactacggt aacagccttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcaac c
//
LOCUS       KCXD01001734             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22775:6179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001734
VERSION     KCXD01001734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22775:6179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60216.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          140 c          148 g           98 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gaaatgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtat attactgtgc gacagggagg
      421 ttcgggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001735             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:19012:13770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001735
VERSION     KCXD01001735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:19012:13770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60217.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       432..440
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          124 c          150 g          105 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcggc
      121 cactctgagg tccagttggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacagt gtcaccgaat tatcgattca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg atcctgtaaa aggtgaagaa
      301 attcacggag aggagttcca ggacagagtc accatgaccg aggacccgtc tacagacaca
      361 gcctacatgg agttgagcaa cctgagatct gaggacacgg ccgtgtatta ttgtgcgagt
      421 gggtttagtg tctggttatt taacgacgtt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001736             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15076:12817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001736
VERSION     KCXD01001736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15076:12817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60218.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          114 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcgt
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atcgccagag
      361 acaattccaa gaacatgcta tatcttcaga tgaacaacct gaaattggcg gacacggccg
      421 tatattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001737             407 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18803:3157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001737
VERSION     KCXD01001737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 407)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 407)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18803:3157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    51..405
                     /note="immunoglobulin heavy chain variable region"
     V_region        51..405
     V_segment       51..344
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <336..>374
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60219.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       354..359
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       363..405
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        406..>407
                     /gene="IGHG"
BASE COUNT           93 a           90 c          123 g          101 t
ORIGIN      
        1 atgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc
       61 tggtggagtc tggaggaaac ttggttcagc ctggggggtc cctgagactc tcctgtgcag
      121 cctctggatt caccttcagt agctatggca tacactgggt ccgccaggct ccagggaagg
      181 ggctggagtg ggtggcagtt atatcctatg atgaaactaa gaaatactac gcagactctg
      241 tgagggaccg attcaccatc tccagagaca attccaaaaa catggtatat cttcaaatga
      301 acaacctgaa attggaggac acggccgtat attactgtgc gagagatgtc aggggaacgg
      361 ggtttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001738             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11093:13632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001738
VERSION     KCXD01001738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11093:13632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60220.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          145 c          140 g           98 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcaatc cggggctgag gtgatgaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggcta caccctcagc atctctgcca tcagttgggt acgacaggcc
      241 cctggacaag ggcttgagtg gatgggagag atcttccctc tggttggtgt gacaaaatac
      301 gcacagaacc tccagggcag agtcacgatt accgcggaca cgtccacaag tacaacctac
      361 atggaactga gcggcctgag atctgaggac acggccgtat attactgtgc gagaagaggt
      421 ggccacggta ccaccaccac gttgtacttc tttgactact ggggccaggg aggcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001739             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14700:8268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001739
VERSION     KCXD01001739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14700:8268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60221.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           91 a          132 c          136 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tgtctggagg
      181 ctccatcagc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tgtatctatg atagcagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaatag acacgtccaa gaaccagttc tccctgaagg tgaggtctat
      361 gaccgccgcg gacacggccg tgtatcactg tgcgagatgg tcggcagcca actttgacta
      421 ctggggtcag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001740             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:9337:14558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001740
VERSION     KCXD01001740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:9337:14558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60222.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       413..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          118 a          139 c          134 g           93 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaggtg gtgcagtctg gggctgaggt gaaggagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tgggaaaggg cttgagtgga tgggaagtgt tgatcctcta tatggtgaaa tgaaacacac
      301 agagttccat gccagattca ccatgaccga ggacacgtct acagacacgg cctacatgga
      361 gctgagcagc ctaagatcag aggacacggc cctgtattac tgtgcagtcg gatatagcgg
      421 cagatggaac aactggtact tcgatctctg gggccctggc accccaatca ccatctcctc
      481 agcc
//
LOCUS       KCXD01001741             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22930:20930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001741
VERSION     KCXD01001741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22930:20930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60223.1"
                     /translation="CARRKYSGYTYGGANFDFW"
     D_segment       403..416
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          133 c          149 g          100 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga gggcttcgga ggccctgtcc ctcacctgca ctgtctctgg
      181 tggctccatg agcggttact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg ggtatcggtg gtggtagtgg gagcaccgat tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaagag acacgtacaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcaagaagg aaatacagcg ggtacacgta
      421 cggaggggcg aactttgact tttggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001742             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24374:13264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001742
VERSION     KCXD01001742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24374:13264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60224.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          123 c          145 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatggctatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001743             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24541:11885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001743
VERSION     KCXD01001743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24541:11885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..441
     V_segment       84..374
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60225.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       383..392
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           77 a          134 c          134 g           98 t
ORIGIN      
        1 acatggggga cctcctgtgc aagaacatga agcacctgtg gttcttcctc ctcctggtgg
       61 tagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca ggactggtga
      121 agccttcgga gaccctggcc ctcacctgcg ctgtctctgg tggctccatc agtggttact
      181 ggtggggctg gatccgccag tccccaggga gggggctgga atggattgga tttttcggtg
      241 gtagtggtgg gaacacctac tacaagtcct ccctccagag tcgagtcacc atttcagccg
      301 acccgtccaa gaaccagttc tccctgatac tgacctctgt gaccgccgcg gacacggccc
      361 tctattactg tgcgcggggg aatatagcag cgactggcat tgactactgg ggccagggac
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001744             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17265:12631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001744
VERSION     KCXD01001744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17265:12631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60226.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          126 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agtctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccgccaga ctccagggaa gggactggag tggatctcag tgattaacag
      301 tggtggagat accacacact atgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccagg aacacactgt ctcttcaaat ggacggcctg agacctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001745             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19576:4384
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001745
VERSION     KCXD01001745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19576:4384"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60227.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       439..450
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          104 a          129 c          159 g          112 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagcac tggaagtcca cagtgttcca ttcggtgatc
       61 agcactgaac acagaggact caccatggag tctgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggcgg cttggcaaag
      181 cctgggggat ccctgagact ctcctgtgca gcctctggat tcaccttcaa tacctatgct
      241 atacactggg tccgccaggc tcccgggaag gggctggact gggtctcagc cattagtagt
      301 ggtgggcgca catactacgc agactccgtg aagggccgag tcaccatctc cagagacaac
      361 tcaaagaaca cggtctccct gcaaatgaac agcctgggag ctgaggacac ggccgtgttt
      421 tactgtgcga gaggggagac agcttcagtt tactacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001746             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14278:20412
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001746
VERSION     KCXD01001746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14278:20412"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60228.1"
                     /translation="CTRADIEAAASFDFW"
     D_segment       426..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          121 a          133 c          127 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatgggct tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtccagtc tggggctgag attaagcagc ctggggcctc agtgaaactc
      181 tcctgcaagg cttctggata tgtcttcatg aactactaca tgcactgggt gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt ataatggtta caaagattac
      301 tcacagaact tccaggacag agtcaccata accacggaca cgtccacgag cacagggtac
      361 atggagctga gaagcctgag atatgaggac acaggcgttt attactgtac gagagcagat
      421 attgaagcgg ctgcctcctt tgacttctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01001747             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11887:11989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001747
VERSION     KCXD01001747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11887:11989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    169..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        169..523
     V_segment       169..448
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <442..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60229.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       456..471
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..523
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          110 a          150 c          154 g          111 t
ORIGIN      
        1 acatggggac tggtgtctgc cgaggtaaat acagatctgt ccttgtccag agagcatcac
       61 acaacagcca cttccctccc ctacagaagc cccagagcac agcacctcac catggactgg
      121 acctggagga tcctcgtctt ggtggcagca gctacaggcg cccactctga ggtccttctg
      181 gtgcagtctg gggctgaggt gatgcagcct ggggcctcag tgaaggtctc ctgcaaggtt
      241 tccggataca ccttcaccga attgtccatg cactgggtgc gacaggcccc tggaaaaggg
      301 cttgagtggg tgggaagtgt tgatcctgta tatggtgaaa tggtgttcca gggcggggtc
      361 accatgaccg aggacacgtc tacagacaca gcctacttgg agctgaacag cctgaggtct
      421 gaagacacgg ccgtgtatta ctgtgcgatt ggccctagcg gcatctggaa cggctggtcc
      481 ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01001748             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14824:20243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001748
VERSION     KCXD01001748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14824:20243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60230.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       421..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          145 c          139 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag ctttccggat ccaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaag gggcttgaat ggatgggagg tgttgctcct ctttatggtg aaatgatgca
      301 cgcagacaac ttccagggca gagtcacctt gaccgaggac ccgtctacag acacagccta
      361 catggagctg agcagcctga catctgacga cacggccgtg tattactgtg cgcgtgggcc
      421 tattacaatt tttggcgtac ttattacggg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001749             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8056:9529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001749
VERSION     KCXD01001749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8056:9529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60231.1"
                     /translation="CARVTGHTEGTVEYFDYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          115 a          119 c          157 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca cttatatcgt
      301 ttgatggaac taagcaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgtta tatcttcaga tgaacaacct gaaattgggg gacacggccg
      421 tgcatttctg tgcgagagtt actgggcata cagagggtac agttgaatac tttgactact
      481 ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01001750             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:3013:7891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001750
VERSION     KCXD01001750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:3013:7891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60232.1"
                     /translation="CARVRGVTIHYLDYW"
     D_segment       404..410
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          139 c          139 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcggc tgcaggagtc
      121 gggcccagga cttgtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggggctggat ccgccggccc ccaggggagg gtctggagtg
      241 gattgggtat atcagtggga gtggtgggag ttccgactac aagtcctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaacta tccactacct
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001751             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11352:14063
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001751
VERSION     KCXD01001751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11352:14063"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60233.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacatagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001752             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6972:6556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001752
VERSION     KCXD01001752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6972:6556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..509
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60234.1"
                     /translation="CAREWIQWTQLVSGLDSW"
     D_segment       440..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..509
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>515
                     /gene="IGHG"
BASE COUNT          118 a          116 c          162 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aaatggagga gtctggagga ggcttggttc
      181 agcctggggg gtcgctgaga ctctcctgtg tggcctctgg attcagcttc aatacctatg
      241 ccatgcactg ggtccgccag actccagggg aggggctgga gtgggtggca gtcatctcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgactcacc atctccagag
      361 acaattccaa gagtacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggag tggatacagt ggacacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcca cagcc
//
LOCUS       KCXD01001753             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11667:16666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001753
VERSION     KCXD01001753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11667:16666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60235.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          120 a          141 c          137 g           95 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtgctt cgatatctgg ggccctggca ccccgatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001754             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18094:13490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001754
VERSION     KCXD01001754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18094:13490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..467
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60236.1"
                     /translation="CARDDDDYVYYYYFDYW"
     D_segment       403..422
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>471
                     /gene="IGHG"
BASE COUNT           91 a          139 c          136 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatcg acagtaaata ctggagctgg atccgccagt ccccagggaa ggggctggag
      241 tggattggac gtgtctctgg tggtggtggg accaccgact acaacccctc cctccagagt
      301 cgagtcacca tctcaaaaga cacgtccaag aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt atattactgt gcgagggacg acgatgatta cgtttactat
      421 tattactttg actactgggg cccgggagtc ctggtcaccg tctcctcggc c
//
LOCUS       KCXD01001755             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22212:7680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001755
VERSION     KCXD01001755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22212:7680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60237.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          144 c          132 g           98 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactgcag gcgcccgctc
      121 tgaggtccac ctggtgcaat ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaaa ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggtcta
      361 catggagctg atcagtctga gatctgaaga cacggccctg tattactgtg cgacatcacc
      421 cagcggcacc tggctatttt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001756             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6293:16414
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001756
VERSION     KCXD01001756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6293:16414"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60238.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       447..452
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          123 c          154 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actactacat
      241 gagttgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttgccgctga
      301 tggggatagc acatactatg cagactccat gaaggccaga ttcactatct ccagagagaa
      361 cgccaagaac acactgcatc ttcaaatgga cagcctgaga gcagaggaca cggctgtcta
      421 ttactgtgtg agagatcgac gtgttcagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctgatc accgtctcct cagcc
//
LOCUS       KCXD01001757             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17935:21903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001757
VERSION     KCXD01001757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17935:21903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60239.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          111 c          161 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca gggtccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa gtaggacata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt gtatgttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001758             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13933:13279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001758
VERSION     KCXD01001758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13933:13279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60240.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>506
                     /gene="IGHG"
BASE COUNT          103 a          127 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtgggact aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag accacactgt atcttcacat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtaagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctgcc
//
LOCUS       KCXD01001759             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22798:12867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001759
VERSION     KCXD01001759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22798:12867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..293
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..293
     V_segment       4..223
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <215..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60241.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       227..234
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       249..293
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        294..>295
                     /gene="IGHG"
BASE COUNT           67 a           85 c           78 g           65 t
ORIGIN      
        1 acatggggac tccatcagca gtagctactg gaactggatc cgccagcccc cagggaaggg
       61 actggagtgg attgggtata tctctggtgc ttatgggagc accagctaca acccctccct
      121 caagggtcga gtcaccattt caacagacac gtccaagaac cacttttccc tgaggctgag
      181 ttctgtgacc gccgcggaca ccgccgtgta ttactgtgtg agatatgagg atgaatccat
      241 taactaccac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001760             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19551:15867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001760
VERSION     KCXD01001760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19551:15867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60242.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       420..424
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          148 c          136 g          100 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccacctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aaatttcctg cggggcttct ggattcacct tcgacaccca tggtatcaac tgggtgcgac
      241 aggcccctgg acaaggactt cagtggatgg gagtgatcat cccccttatt ggtatcacca
      301 actacgcaaa gaactctcag ggcagagtca cactaaccgc ggacacgtcc acaaacacag
      361 cctacatgga gctgaacagc ctgagatttg aggacacggc catctactac tgtgcgagag
      421 aacgctgcac ttctagtgtt tgcgccgggt tccttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001761             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21857:6011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001761
VERSION     KCXD01001761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21857:6011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60243.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          120 a          141 c          135 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtgcttcg atatctgggg ccctggcacc ccgatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001762             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22111:12403
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001762
VERSION     KCXD01001762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22111:12403"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60244.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       415..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          113 a          139 c          144 g          101 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgt cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga accctggtgc ctcagtgaag ctctcctgca
      181 agggttctgg attcaccctc agcaccgagg ccatcagttg ggtgcgacag gcccctggac
      241 aaggacctga ctggatggga gggatcatcc ctctcgtggg tgcaacaaac tacgcacaga
      301 agttccaggg cagagtcaag tttaccgcgg acacgtccat aaacacagcc tacatggaac
      361 tgagcggcct gagatctgag gacacggccg tgtattattg tgcgaaatcc gtgaattacg
      421 aggaagataa cggttactat ttaccgacgg ggtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01001763             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19506:16717
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001763
VERSION     KCXD01001763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19506:16717"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60245.1"
                     /translation="CASGGYEDDSGFYFPDFFDSW"
     D_segment       420..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          106 a          135 c          145 g          115 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgtccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg ctgctggata catctttagt atctctgcca tcagttgggt gcgacaggcc
      241 cctggacagg gacttgagtg gatgggaggg atcatccctc ttgttggtgt aacaaataac
      301 gcacggaagt tccagggcag agtcacgatt accgcggaca cgtccacaag cacagccttc
      361 atggatctga gcagcctgag atctgaggac acggccgtct attattgtgc gagcggtggt
      421 tacgaggatg attccggttt ttattttcca gacttctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001764             532 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21529:12162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001764
VERSION     KCXD01001764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 532)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 532)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21529:12162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    170..530
                     /note="immunoglobulin heavy chain variable region"
     V_region        170..530
     V_segment       170..461
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <455..>499
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60246.1"
                     /translation="CTKDDVVVFSGPVDW"
     D_segment       471..478
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       495..530
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        531..>532
                     /gene="IGHG"
BASE COUNT          113 a          132 c          156 g          131 t
ORIGIN      
        1 acatggggga aaaccagccc agctctgact ctgcagctct aggagaggag cccagccctg
       61 ggattcccag gtgttttcat ttgtgatcag cactgaacac agaagactca tcatggagtt
      121 tggcctgagc tgggttttcc ttgttgctat tttaaaaggt gtccagggtg aggtgcaatt
      181 ggtggagtct gggggcggct tggcgaagcc tggggggtcc ctgagactct cctgtgcagc
      241 ctctggattc accttcagta actactggat gtactgggtt cgccaggcac ctgggaaggg
      301 cctggagtgt atctccgcta ttaatcctgc tggtggcagc acgtactatg cagactccgt
      361 gaagggcaga ttcaccatct ccagggagaa cgccaagaac acactatatc ttcaaatgaa
      421 cagcctgaga gctgaggaca cggctgtcta tttctgtacg aaagatgacg ttgtagtctt
      481 ttctggtccc gtagactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001765             377 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22057:12659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001765
VERSION     KCXD01001765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 377)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 377)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22057:12659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    220..375
                     /note="immunoglobulin heavy chain variable region"
     V_region        220..375
     V_segment       220..314
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <306..>344
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60247.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       323..329
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       336..375
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        376..>377
                     /gene="IGHG"
BASE COUNT           83 a           92 c          109 g           93 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttcttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaca ctctcctgtg cagcctctgg attcaccatt tccagagaca
      241 attccaagaa cacgctatat cttcaaatga acaacctcca attggaggac acggccgtgt
      301 attactgtgc gagagatgat aatggggtgc ttatcgactt ctggggccag ggagtcctgt
      361 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001766             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12548:14233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001766
VERSION     KCXD01001766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12548:14233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60248.1"
                     /translation="CARDVYGGGLDYW"
     D_segment       441..446
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          116 c          150 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtccacc tggtggagtc tggaggaggc ttggttcagc
      181 ctggtgggtc cctgagactc tcctgttcag cctcaggatt caccttcaac acctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcagtt atatcgtctg
      301 atggaagtaa gaaatactac gcagactctt tgagagaccg attcaccata tccagagaca
      361 gctccaagaa catggtatat cttctactga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgc gagagatgtt tatggtgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001767             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9654:19095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001767
VERSION     KCXD01001767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9654:19095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60249.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          115 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaaa taacatatac tacgcagcct ctgtgaagga ccgattcgcc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaatttgag gacacggccg
      421 tgtattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001768             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20212:8838
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001768
VERSION     KCXD01001768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20212:8838"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60250.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          141 c          137 g          104 t
ORIGIN      
        1 acatgggggc agcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccgcctggtg cagtccggga ctgaggtgaa gaagcctggg gcctcagtga
      181 agatttcctg cggggcttct ggattcaccc tcgacaccta tggtatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat cccccttatt ggtatcatca
      301 actacgcaga gaactctcag ggcagactca caataaccgc gaacacgtcc acaaatacag
      361 cctatatgga actgagcagt ctgagatctg aggacacggc catctattac tgtgcgagag
      421 aatactgtac ttctagtact tgcgccgggt tccttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001769             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10519:18805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001769
VERSION     KCXD01001769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10519:18805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..433
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60251.1"
                     /translation="CARVPGLVVFSGSLDYW"
     D_segment       444..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          108 a          117 c          156 g          127 t
ORIGIN      
        1 acatggggct aggagaggag cccagccctg ggattcccag gtgttttcat ctgtgatcag
       61 cactgaacac agaagactca tcatggagtt tggcctgagc tgggttttcc ttgttgcttt
      121 tttaaaaggt gtccagggtg aggtgcagtt ggtggaatct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accctcagta actactggat
      241 gtattgggtt cgccaggcac cagggaaggg actggagtgg atctcaggta taaatagtgt
      301 tgggagtagt acatactatg cagactccgt gaagggcaga ttcaccatat ccagagagaa
      361 cgcccagaac acactttttc ttcaaatgga cagcctgaga cctgaggaca cggctgtcta
      421 ttactgtgcg agagttccgg gcctagtggt gtttagcggt tcgcttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001770             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16460:6883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001770
VERSION     KCXD01001770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16460:6883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60252.1"
                     /translation="CASGSRRQPDKW"
     D_segment       405..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..454
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           85 a          139 c          141 g           91 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatcggtgg aactagtggg agcacctact acaacccctc cctcaagagc
      301 cgagtcacca tttcaacaga cacgtccaag gaccaggtct ccctgaagtt gagcactgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagcggaa gtcggcggca gccggataaa
      421 tggggccagg gcctcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001771             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21199:15320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001771
VERSION     KCXD01001771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21199:15320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60253.1"
                     /translation="CASPLLPAAGNW"
     D_segment       408..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           82 a          141 c          128 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cccgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tccaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcgctg tctctggtta
      181 ctccgtcgac agtggttact cctggggctg gctccgtcag cccccaggga agggactgga
      241 gtggattgga tttatcggtg gtcgtagtgg gttcacctac tacaacccct ccctgaagag
      301 tcgagtctcc atttcaaaag acacgtccaa taaccagttc tccctgagac tgaactctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagtcct ctccttccgg cagctggaaa
      421 ctggggccag ggaatcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001772             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20573:9619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001772
VERSION     KCXD01001772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20573:9619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60254.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          142 c          129 g           91 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaggct tctggataca ccttaaccga ccactaccta cactgggtgc gacaggctcc
      241 tggaaaagga cctgagtgga tgggaggtat tcaccctgag tatggtaaag tagactacac
      301 acagaagttc cgagacagag tcaccatcat cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgacttct ggggccaggg agccctagtc gccgtctcct cagcc
//
LOCUS       KCXD01001773             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20461:12261
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001773
VERSION     KCXD01001773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20461:12261"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60255.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           95 a          131 c          127 g          106 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 agcagtagct actggaactg gatccgccag cccccaggga agggactgga gtggattggg
      241 tatatctctg gtagttatgg gagtaccagc tacaacccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgagcc tgagttctgt gaccgccgcg
      361 gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaatta ccactttgat
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001774             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20017:17574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001774
VERSION     KCXD01001774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20017:17574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60256.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          109 c          154 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcaggagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atattacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001775             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21101:15509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001775
VERSION     KCXD01001775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21101:15509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60257.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          120 c          148 g          119 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagaaatac tacatagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001776             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:2611:10725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001776
VERSION     KCXD01001776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:2611:10725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60258.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       442..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          118 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtcactttgg
      241 cttacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatctcgca
      301 tgatggcaat aacatatact acgcagactc tatgaaggac cgattcacca tctccagaga
      361 caattcgaag aacatggtat atcttgaaat ggacaacctg caattggagg acacggccgt
      421 gtatttctgt gtgagagatg cctacggtac cgggttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001777             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10076:5938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001777
VERSION     KCXD01001777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10076:5938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60259.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          145 c          138 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cggattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cgttgatcct gcatatggtg aatttacacc
      301 cggagagaag ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta
      361 catggagctg agcagcctga actctgagga cacggccgtc tattactgtg cagccgggta
      421 tagcggcagc tggaaccact ggtacttcga tctctggggc cctggcaccc ctatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001778             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9929:12188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001778
VERSION     KCXD01001778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9929:12188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60260.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          142 c          133 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga accctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctaaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacctca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001779             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17338:13445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001779
VERSION     KCXD01001779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17338:13445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60261.1"
                     /translation="CASGPSGTWNDWYFDIW"
     D_segment       428..440
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          146 c          135 g           92 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaactgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgac tggatgggaa gtgttgatcc tctatatggt gaaatgatac
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gaccagcctg agatctgagg acacggccgt gtattattgt gcgagtggcc
      421 ctagcggcac ctggaacgac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001780             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17061:12433
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001780
VERSION     KCXD01001780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17061:12433"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60262.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       443..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          111 c          153 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgcgatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 gaggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttt ctatggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ttcgaatgat
      301 gaaactaaga aatactacgc agactctgtg aaggaccgat tcaccatttc cagagacaat
      361 tccaagaaca tgctatttct tcaaatggac aacctgaaat tggaggacac ggccgtctat
      421 tattgtgtga gagatgattt aggcagcggc ttagggtcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001781             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:17678:15987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001781
VERSION     KCXD01001781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:17678:15987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..461
     V_segment       83..376
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60263.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       380..390
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..461
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           96 a          125 c          141 g          101 t
ORIGIN      
        1 acatggggga acacagctca tcaccatgga cttgacctgg aggctcctct ttgtggtggc
       61 agcagctaca ggtgcccagt ctcaggtcca gctggtgcag tccggggctg agatggagaa
      121 gcctggggcc tcagtgaagc tctcctgtaa ggcttctgga tacagcttca gcatctatgt
      181 catcagttgg gtgcgacagg cccctggaca agggcttgag tggatgggag gcatcttccc
      241 tcttgttggt acaacaaact acgcacagaa gttccagggc agagtcacga ttaccgcgga
      301 cacggccaca agcacagcct acatggacct gagcagcctg ggatctgggg acacggccgt
      361 gtattattgt gcgagaggtt actgtactgg caatggttgt aaccttactt tcaaccggct
      421 cgatgtctgg ggcccgggag tcccggtcac cgtctcctca gcc
//
LOCUS       KCXD01001782             528 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5018:10413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001782
VERSION     KCXD01001782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5018:10413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..526
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..526
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>495
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60264.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       452..471
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       484..526
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        527..>528
                     /gene="IGHG"
BASE COUNT          113 a          131 c          156 g          128 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg caactggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttac
      241 gacatgacct gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 tacactggta aaaccatata ctactctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgtca agaactctct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattatt gttctagagc ggcttacgaa catgatgacg gttactatta cgtcggcagg
      481 ttttttgact gctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001783             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19322:5672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001783
VERSION     KCXD01001783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19322:5672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60265.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           98 a          138 c          125 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accaatagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattgga tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001784             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:22343:14853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001784
VERSION     KCXD01001784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:22343:14853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60266.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       437..444
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          124 a          142 c          140 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagccaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aagttaagaa gcctggggcc tcagtgatgg
      181 tctcctgcca ggtttccgga tacaccgtca ccgaaatatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgctcc tgaaaaaaat gagttaatac
      301 acgcagacaa gttccaggac agagtcagca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtggcctg acatttgagg acacggccgt gtattactgt gcgacccacg
      421 gaggttatag cgacatctgg aactccctat ataacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001785             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23211:13084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001785
VERSION     KCXD01001785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23211:13084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60267.1"
                     /translation="CARDAFGSGLDYW"
     D_segment       447..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          118 c          150 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tctcttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagatatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatttcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgcttcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctt aaattggagg acacggccgt
      421 gtattactgt gcgagagatg ctttcggcag cgggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001786             403 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:15750:21998
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001786
VERSION     KCXD01001786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 403)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 403)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:15750:21998"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    227..401
                     /note="immunoglobulin heavy chain variable region"
     V_region        227..401
     V_segment       227..337
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <329..>370
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60268.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       344..350
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       354..401
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        402..>403
                     /gene="IGHG"
BASE COUNT           90 a          102 c          113 g           98 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccac tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagt tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcaga aactatgact ctgtgaagga
      241 ccgaatcacc atctccagag acaattccaa gaacacgctt tttcttcaaa tgaacaacct
      301 gaaattggag gacacggccg tgtattactg tgcgagacgc ccttggaacg ctgactactt
      361 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001787             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:5886:9409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001787
VERSION     KCXD01001787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:5886:9409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60269.1"
                     /translation="CARELYNSGWADAFDFW"
     D_segment       442..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..509
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          110 a          110 c          169 g          122 t
ORIGIN      
        1 acatgggggg tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatcttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag gtgtgtcgta
      301 tgatgggagt gagagagact acgcagactc tgtgaaggac cgaatcacca tttccagaga
      361 caattccaag aacatggtat atgttcaaat gaacagcctg aaattggagg acacggccgt
      421 gtattactgt gcgagagagc tgtataacag cggctgggct gatgcctttg atttctgggg
      481 ccaagggctc agggtcaccg tctcttcagc c
//
LOCUS       KCXD01001788             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10665:7861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001788
VERSION     KCXD01001788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10665:7861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60270.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       408..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           95 a          133 c          135 g          115 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 aggctctctc agcggtgctt atgactggag ctggatccgc cagcccccag ggaaggggct
      241 ggaatggatt ggctatatct atggtggtag tgggagtacc acctacaacc cgtccctcag
      301 gaatcgagtc accatttcaa aagacacgtc caagaaccag ttgtccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtatatta ttgtgcgaga cagtgttgtt actatgatga
      421 ctttttagac tactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001789             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:3301:12431
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001789
VERSION     KCXD01001789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:3301:12431"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60271.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          113 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtaactatg
      241 gaatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggcgg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01001790             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10755:11703
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001790
VERSION     KCXD01001790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10755:11703"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60272.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       416..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          141 c          135 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag gagcctgggg cctcagcgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 acacacagag ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctaa gatctgagga cacggccctg tattattgtg cagtcgggta
      421 tagcggccga tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01001791             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24609:11675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001791
VERSION     KCXD01001791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24609:11675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60273.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       406..410
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..465
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          101 a          109 c          140 g          117 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttccta ttttaagagg tgtccagtgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc ctggggagtc cctgagactc tcctgtgcag
      181 cctctggatt caccttcagt acctctggca tgcactgggt ccgccaggct ccagggaagg
      241 ggctggagtg ggtgtctgta atttcgtctg atggaagtaa gaaatactac gcagactctg
      301 tgaaggaccg attcaccatc tccagagaca actccaagaa cacactatat tttcaaatga
      361 acaacctgaa attggaggac acggccgtgt atttctgtgt gagagatgcc ttcgggggcg
      421 gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001792             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20465:11796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001792
VERSION     KCXD01001792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20465:11796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60274.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          110 c          158 g          120 t
ORIGIN      
        1 acatgggggt ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      301 ttgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001793             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11937:11499
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001793
VERSION     KCXD01001793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11937:11499"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60275.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          140 c          144 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctctcctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 tacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01001794             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10715:11408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001794
VERSION     KCXD01001794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10715:11408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60276.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcattg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatccc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgagcaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01001795             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14428:7320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001795
VERSION     KCXD01001795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14428:7320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60277.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          140 c          153 g          104 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccct
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgagg aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggttggg aggtgttgat cctgcaaatg gtgaggtaat
      301 acacgcagat agttttcagg gcagagtcac catgaccgag gacacgtcta cactcacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 gcggttcggt agcagcgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001796             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12162:8302
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001796
VERSION     KCXD01001796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12162:8302"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60278.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          105 a          124 c          158 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gtctctggat tcagtttcag tcactacttc
      241 atgagctggg tccgccaggc tccagggaag ggactggagt ggatctcagg gattaacagt
      301 ggtggagata ccacacacta tgcagactcc gtgaagggca gattcaccat gtccagagag
      361 aacgccaaga acacactgtc ccttcaaatg gacggcctga gagctgaaga ctcggctgtc
      421 tattattgtg cgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001797             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18363:13838
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001797
VERSION     KCXD01001797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18363:13838"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60279.1"
                     /translation="CARWSAANFDSW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           87 a          136 c          136 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca acagtggtta tggctggagc tgggtccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtgtctcta tgatagtagt gggaacacgt actacaaccc ctccctcaag
      301 agtcgcgtca ccatttcaaa agacacgtcc aagaaccagt tctccctgag cctgaggtct
      361 atgaccgccg cggacacggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac
      421 tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001798             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17669:11212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001798
VERSION     KCXD01001798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17669:11212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..429
     V_segment       75..368
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60280.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       377..389
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           96 a           91 c          135 g          109 t
ORIGIN      
        1 acatgggggg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
       61 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagccggggg
      121 ggtccctgag actctcctgt gcagcttcgg ggttcatctt cagtagttat ggcatgcact
      181 gggtccgcct ggctccaggg aaggggctgg agtgggtggc agtaacatcg tctgatgaaa
      241 gtaagaaatt ctacggagac tctgtgaagg accgattcac catctccaga gacaattccc
      301 agaacatact atatcttcaa atgaacaacc tgaaattgaa ggacacggcc gtctactatt
      361 gtgggagaga tgataatggg gtgattattg actactgggg ccagggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01001799             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:25582:4043
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001799
VERSION     KCXD01001799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:25582:4043"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60281.1"
                     /translation="CVRDAYGAGLDVW"
     D_segment       435..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          106 c          162 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taggaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg ggtcagccgg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtacc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtttta tcgaatgatg
      301 gaagtaagaa atactacgga gaccctgtga aggaccgatt tatcatctcc agagacaatg
      361 ccaagaacac tgtctatctt caagtgaata atctgaaaat ggaagacacg gccgtgtatt
      421 actgtgtgag agacgcatat ggggcgggat tggatgtctg gggccgggga gttctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001800             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22933:17410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001800
VERSION     KCXD01001800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22933:17410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60282.1"
                     /translation="CARGIDNYHYSNTDFDYW"
     D_segment       452..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          118 c          149 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcacgactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg actgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat gtccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001801             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11018:11198
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001801
VERSION     KCXD01001801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11018:11198"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..286
     V_segment       7..225
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60283.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       227..231
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..286
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           71 a           65 c           83 g           69 t
ORIGIN      
        1 acatggggat tcaccttcag tatatctggc atgcactggg tccgccaggc tccagggaag
       61 gggctggagt gggtgtcagt tatatcgtct gatggaagta agaaatacta cgcagactct
      121 gtgaaggacc gattcaccat ctccagagac aattcaaaaa acatggtata tcttcaaatg
      181 aacaacctga aattggagga cacggccgtg tatttctgtg tgagagatgc cttcgggggc
      241 ggtttggatt cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001802             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6539:11338
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001802
VERSION     KCXD01001802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6539:11338"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..400
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60284.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       406..425
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           93 a          140 c          132 g          112 t
ORIGIN      
        1 acatggggat gctgtctgag agtcagggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc aggtcccaga tgggtcctgt cccagccgca gctgcagttg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcgc ctgcgttgtc
      181 tctggtggct ccatcagcga ttactcctgg agctggatcc gccagccccc agggaaggga
      241 ctggagtgga ttgggaatat tgatgttcat cttgcgggcc ccaactacaa cccctccctc
      301 aagagtcgag tcgccatttc aaaagacacg tccaagaatc agttctccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtatat ttctgtgcga aacaatatag tggtagttat
      421 tactattccc actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001803             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:24463:17083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001803
VERSION     KCXD01001803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:24463:17083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60285.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          107 a          122 c          155 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag tttctactac
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacgct
      301 gatggggata gcacatacta tgcagactcc atgaagggca gattcactat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagcagagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctga tcaccgtctc ctcagcc
//
LOCUS       KCXD01001804             364 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6887:9936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001804
VERSION     KCXD01001804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 364)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 364)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6887:9936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..362
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..362
     V_segment       8..301
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>331
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60286.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       305..317
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..362
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        363..>364
                     /gene="IGHG"
BASE COUNT           82 a           83 c          116 g           83 t
ORIGIN      
        1 acatggggag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg gggggtccct
       61 gagactctcc tgtgcagtct ctggattcac cttcagtagc tttggcatgc actgggtccg
      121 ccaggctcca gggaaggggc tggagtgggt ggcagtgaca tcgtatgatg gaagttggaa
      181 gtactacgga gactctgtga gggaccgatt caccatctcc agagacaatt ccaagaacat
      241 gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt actgtgcgag
      301 aggggaatac agtaactctg ttgactactg gggccaggga gtcctggtca ccgtctcctc
      361 agcc
//
LOCUS       KCXD01001805             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20458:18161
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001805
VERSION     KCXD01001805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20458:18161"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60287.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       399..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          139 c          138 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctctggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatgagc agtcactact gcagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgg atctctggta gtggtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccctc tcaacagaca cgtccaagaa ggagatctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gcgagaagac tatggtggta attattactt
      421 taaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001806             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23823:4650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001806
VERSION     KCXD01001806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23823:4650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60288.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       438..443
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          116 c          145 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
      241 gcatacactg ggtccgccag gctcccggga agggtctgga gtgggtagca gttatctccc
      301 atgatgagaa taatatatat tacgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaacgta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttttactg tgtgagagat acattcggtt caggatttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001807             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:12427:4081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001807
VERSION     KCXD01001807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:12427:4081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60289.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          119 a          142 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag tctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atccactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccct
      481 ctcctcagcc
//
LOCUS       KCXD01001808             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:23211:6536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001808
VERSION     KCXD01001808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:23211:6536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..347
     V_segment       8..277
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60290.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       282..295
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..347
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>349
                     /gene="IGHG"
BASE COUNT           70 a           96 c          105 g           78 t
ORIGIN      
        1 acatggggga ctggtgaagc cttcggagac cctgtccctc acttgcgttg tctctggcca
       61 ctccatcagc agtggctacc actggggctg gatccgtcag cccccaggga agggactgga
      121 ctatattggc tatatcagtg gtagtagtgg gagcacctac tacaagccct ccctcatgag
      181 tcgagtcatc atttcaagag acacgtcccg gaatgagttc tccctgaggc tgaggtctgt
      241 gactgtcgcg gacacggccg tgtattattg tgcgagacga gatagctgga acaacggggg
      301 gagccttgac tactggggcc agggattcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001809             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9917:14496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001809
VERSION     KCXD01001809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9917:14496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60291.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       442..447
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          112 c          154 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaagtgca actggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtggctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaatatt acgcagactc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aacatgctat attttcaaat gaacaacctg aaattggaag acacggccgt
      421 gtattactgt gcgagagatg tctatggcag gggacttgac tactggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001810             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17486:10912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001810
VERSION     KCXD01001810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17486:10912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60292.1"
                     /translation="CARWGTPFDYW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           90 a          134 c          132 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcttgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 agctccatca acagtggtta tgcctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtgggttg gacatatcta tgatagtagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagat gggggacccc ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001811             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11559:11988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001811
VERSION     KCXD01001811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11559:11988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60293.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           91 a          138 c          130 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtaatagtgg taccacctac tacaacccct ccctcaagag
      301 tcgagccacc atttcaaaag acacgtccaa caatcaactc tccctgaagg tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat gaagacccct ccatttttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001812             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14659:16632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001812
VERSION     KCXD01001812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14659:16632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60294.1"
                     /translation="CARSSSGSWINWYFDIW"
     D_segment       424..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          143 c          136 g           90 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg acacaccttc accgagctat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtatatgg tgaaataagg
      301 aacacagaca acttccaggg cagagtcacc atgaccgagg acacgtcaac agacacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattattg tgcgagatca
      421 tccagcggca gctggataaa ctggtacttc gatatctggg gcccaggcac cccagtcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001813             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12363:10221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001813
VERSION     KCXD01001813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12363:10221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..255
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60295.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       263..278
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..330
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           74 a           85 c          104 g           69 t
ORIGIN      
        1 acatggggat gcagcctggg gcctcagtga aggtctcctg caaggtttcc ggatacacct
       61 tcaccgattt gtccatacac tgggtgcgac aggcccctgg aaaagggctt gagtgggtgg
      121 gaagtgttga tcctgaatat ggtgaaatga cgttccaggg gagagtcacc atgaccgagg
      181 acacgtctac agacacggcc tacatggagc tgagtagcct gagatctgag gacacgggcg
      241 tgtattactg tgcgattggc cctagcggca ggtggaacca ctggtccttc gagatctggg
      301 gacctgggac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01001814             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:27105:16299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001814
VERSION     KCXD01001814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:27105:16299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60296.1"
                     /translation="CATGRIGASGWSNLFNGLYSW"
     D_segment       431..441
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          145 c          141 g           99 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc cccaacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccacc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccgtcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggactt gttgatcctg taaatggtga gctaatacac
      301 gcagacaagt tccagggcag agtcaccatg accgaagaca cgtctacaga cacagcctac
      361 atggagttga gcagcctgac atctgaggac acggccatct acttctgtgc gacagggagg
      421 atcggtgcca gtggctggtc caacctcttc aatggtttgt attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcttcagc c
//
LOCUS       KCXD01001815             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13383:15894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001815
VERSION     KCXD01001815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13383:15894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60297.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       415..437
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           99 a          141 c          139 g          116 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtga tgtctctggt
      181 gcctccatca gtacttcctg gtggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg ttatagtggt agtttttact ccaacccctc cctcaacagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccagttcg ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt atattactgt gcgcgagatg ccgggtttgg ggaaacgata
      421 ttagtagtcg atattaatat gttcccccac tttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001816             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15075:11291
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001816
VERSION     KCXD01001816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15075:11291"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..516
     V_segment       141..440
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60298.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       443..449
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..516
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          117 a          123 c          157 g          121 t
ORIGIN      
        1 acatgggggg ggagaggaga cccagccttg ggattcccag gcgtctccac ttggtgatca
       61 gcactgaaca caagagactc accatggagt ttgtactgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggcgggtc cctgagactc tcctgtgcag gctctggatt caccttcagt gactatgcca
      241 tgagctgggt ccgccaggct tctgggaaag gactggagtg ggttggctat attagaagca
      301 aatcttacaa ttacgcgaca gaatacgccg catcggtgaa aggcaggttc accatctcca
      361 gagatgattc aaagaacacc ctacatctgc aaatgagcag cctgaaaatc gaggacacgg
      421 ccgtgtatta ctgtgctaga ggggatatac cggctataga ggcctactac ggtttggatt
      481 cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001817             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20350:4766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001817
VERSION     KCXD01001817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20350:4766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..523
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60299.1"
                     /translation="CTAEITVEIVATPRSYDYW"
     D_segment       450..475
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       483..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          121 a          128 c          151 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattt ccagctgtct ccacttggtg
       61 atcagcactg aacacaggag actcgccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg agacttagtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgactat
      241 gccatgggct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      301 agcaactata accattacgc gacagaatac gccgcatcgg tgaaaggcag attcaccatc
      361 tccagagatg attcaaagaa cacgctatat ttgcaaatga gcagcctgaa aaccgaggac
      421 acggccgtgt attactgcac cgcagaaatc actgtagaga tagtggctac tcctcgttct
      481 tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001818             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11951:10493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001818
VERSION     KCXD01001818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11951:10493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60300.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          138 c          131 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggcga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccgtc accagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaggag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001819             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13681:12699
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001819
VERSION     KCXD01001819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13681:12699"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..488
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60301.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       430..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>495
                     /gene="IGHG"
BASE COUNT          114 a          139 c          140 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cggcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg gctgcgacag
      241 gcccctggaa aagggcttga gtggttggga agtgttgatt ataaatatga tgaagtaatc
      301 cacgcagaca atttccagga cagagtcacc atgaccgagg acacgtcaac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtatttctg tgcggcgggc
      421 cttgggggat atttactgct tactgaatat ttccagttct ggggccaggg cgccctggtc
      481 accgtctctt ccgcc
//
LOCUS       KCXD01001820             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:6865:15056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001820
VERSION     KCXD01001820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:6865:15056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..488
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60302.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       437..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>494
                     /gene="IGHG"
BASE COUNT          108 a          116 c          151 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccgttcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tttggcatgc
      241 actgggtccg ccagactcca gggaaggggc tggagtgggt ggcagttata tcgcatgata
      301 gaaataatat atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 cgaagaacat gctgtatctt caaatgaaca acctacagtt ggaggacacg gccgtgtatt
      421 cctgtgtgcg agatgcctac ggtaccgggt tggattcctg gggccaaggc gtcgtcgtca
      481 tcgtctcccc agcc
//
LOCUS       KCXD01001821             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18810:17191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001821
VERSION     KCXD01001821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18810:17191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60303.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          131 c          138 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgggtctatc agaagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaagt tgagcgctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001822             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8609:3973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001822
VERSION     KCXD01001822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8609:3973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60304.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          109 a          121 c          159 g          121 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtccg gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactgttg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattact gtactaggaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001823             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19488:12942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001823
VERSION     KCXD01001823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19488:12942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60305.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          155 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccac tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagtctctgg gttcaccttc agtggctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggccgga atgggtggcg gttatatcga
      301 atgatggaac taacaaatac tacgcagact ctctgaagga ccgatttagt atctccagag
      361 agaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tctattactg cgcgacagat gcgtttggta gcgggattga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001824             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13848:12646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001824
VERSION     KCXD01001824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13848:12646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60306.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       443..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          115 c          153 g          120 t
ORIGIN      
        1 acatgggggc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgtta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggctt caccttcaat tcctttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcggtt atatcgcatg
      301 atgaaactaa gaaatactac gcagactctg tgaaagaccg attcagcatc tccagagaca
      361 attccaagaa catggtctat cttcaaatga acaacctgag attggaggac acggccgtct
      421 attactgtgt gagagatgcg tttggtagcg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001825             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:2389:15134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001825
VERSION     KCXD01001825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:2389:15134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60307.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          153 g          118 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag actccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaagtac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggtc tatcttcaaa tgaacaacct gaagttggag gacacggcca
      421 tatattactg tgttagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001826             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14608:17859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001826
VERSION     KCXD01001826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14608:17859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60308.1"
                     /translation="CARGYCSGSFCSSAFDYW"
     D_segment       426..436
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          118 a          129 c          145 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtcaggggct gagatgaaga agcctggggc ctcagtgaag
      181 gtctcttgca aggtttccgg aaacaccttc agcgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga ggtgttgaac ctggatatgg tgaaataata
      301 tatgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gagatctgag gatacggccg tttattactg tgcgagggga
      421 tactgtagtg gtagtttctg ttcgtcagcc tttgattact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001827             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18506:11024
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001827
VERSION     KCXD01001827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18506:11024"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..490
     V_segment       127..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60309.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       418..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          141 c          135 g           96 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaggtggt gcagtctggg gctgaggtga aggagcctgg ggcctcagcg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctctata tggtgaaatg
      301 aaacacacag agttccatgc cagattcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tgagcagcct aagatctgag gacacggccc tgtattattg tgcagtcggg
      421 tatagcggcc gatggaacaa ctggtacttc gatctctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001828             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20416:11977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001828
VERSION     KCXD01001828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20416:11977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60310.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          124 c          148 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcccctt cactacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctcg agtggctgac agttatatcg
      301 tttgatgaaa ctaaggaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggc cgaggctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001829             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9532:9516
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001829
VERSION     KCXD01001829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9532:9516"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60311.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          135 c          144 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccattagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga ccagttctcc ctgagtctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgg cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001830             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:5527:11961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001830
VERSION     KCXD01001830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:5527:11961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..434
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <433..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60312.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       449..463
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          114 a          125 c          147 g          130 t
ORIGIN      
        1 acatggggct gggagaggag acccagcctt gggatttcca gctgtctcca cttggtgatc
       61 agcactgaac acaggagact cgccatggag tttgtactga gctgggtttt ccttgttgct
      121 atattaaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggtccag
      181 cctggcgggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tgactatgcc
      241 ctgagctggg tccgccaggc ttctgggaaa ggactggagt ggattggcta tattagaagc
      301 caatataaca atttcgcgac agaatacgcc ccatcggtga aaggcagatt cgccatctcc
      361 agagatgatt caaagaacac gctatttctg caaatgagta gcctgaaaac cgaggacacg
      421 gccgtgtatt actgcaccac ccattttggt ggtaattatt acttggacta ctttgtctac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001831             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18836:18542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001831
VERSION     KCXD01001831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18836:18542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..477
     V_segment       124..417
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60313.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       421..436
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>480
                     /gene="IGHG"
BASE COUNT          102 a          147 c          126 g          105 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gtgcttcatt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcgcc ctcctcctgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggaaca gaggtgaaaa ggcccgggga gtctctgagg
      181 atctcctgtc agacctctgg atacaacttt cccagcagct ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg accatctatc ctgctgattc taatgccaaa
      301 tacaacccgt ccttccaagg ccacgtcact atctcagtcg acaagtccat cagcaccacc
      361 tacttgcagt ggagcaacct gaaggcctcg gacaccgcca cgtattactg tgccaaaacc
      421 tactatagtg gtagtttgga atactggggc cagggagtcc tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01001832             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18054:5094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001832
VERSION     KCXD01001832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18054:5094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60314.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           83 a          139 c          136 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggta gtggtgggag cacctactac aaatcctccc tccagagtcg
      301 cgtcaccatt tcaaccgaca cgtccaagaa ccagttctcc ctaatactga cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001833             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18508:9175
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001833
VERSION     KCXD01001833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18508:9175"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60315.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       408..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          127 c          139 g          110 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg atttaccttc gacaactatg gaatcaactg ggtgcggcag gcccctggac
      241 aagggcttga gtggatgggc gtggtcatcc cccttgttgg tattattaat tatgcagaga
      301 acttccaggg cagagtaacg attaacgcgg acacgtccat aaacacagcc ttcatggaat
      361 tcaggagcct gagatctgac gacacggcca tttatttctg tgcgagagaa tactgtacaa
      421 ctactgactg cgccgggttc tttgactact ggggccaggg agtcatggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01001834             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21328:15769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001834
VERSION     KCXD01001834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21328:15769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60316.1"
                     /translation="CARRKYSGYTYGGANFDFW"
     D_segment       404..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           96 a          133 c          150 g          100 t
ORIGIN      
        1 acatgggggg atgctctctg agagtcatgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg agggcttcgg aggccctgtc cctcacctgc actgtctctg
      181 gtggctccat gagcggttac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gggtatcggt ggtggtagtg ggagcaccga ttacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaga gacacgtaca agaaccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcaagaag gaaatacagc gggtacacgt
      421 acggaggggc gaactttgac ttttggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001835             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8302:18278
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001835
VERSION     KCXD01001835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8302:18278"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..493
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60317.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       432..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          117 a          142 c          142 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggctgg gaggtgtcga tcttgcatat gatgaaataa
      301 tatacgcaga gaagttccaa ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagc ctgaaatctg aggacacggc cgtgtattac tgtgcggcgg
      421 gccttggggg atatttactg ctcactgaat acctcgagtt ctggggccag ggcgccctgg
      481 tcaccgtctc ctccgcc
//
LOCUS       KCXD01001836             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:20097:6921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001836
VERSION     KCXD01001836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:20097:6921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60318.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          109 a          118 c          157 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcaattatt actacgtgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atagtggtgg
      301 ggaaagcaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacacg ctatatcttg aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ttgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001837             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24472:10156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001837
VERSION     KCXD01001837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24472:10156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60319.1"
                     /translation="CARYEGAAAGTWFFDYW"
     D_segment       406..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          139 c          133 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccaatcatta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tgggttgggt ctctctatgg tgctactggg agcaccaact ataatccctc cctcaagagt
      301 cgagtcagca tttcaacaga catgtccaag aaccagtttt ccctgaaact gacctctgtg
      361 accgccgcgg acaccgccgt gtattattgt gcgagatatg agggggcggc agctggaacc
      421 tggttctttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001838             529 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13855:16872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001838
VERSION     KCXD01001838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 529)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 529)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13855:16872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..527
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..527
     V_segment       146..438
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>496
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60320.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       453..472
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       485..527
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        528..>529
                     /gene="IGHG"
BASE COUNT          113 a          132 c          157 g          127 t
ORIGIN      
        1 acatggggga gctctgagag aggagcctta gccctggatt tcaaggcact tccacctggg
       61 gatcagcact gaacacagag gacccaccat ggagttgggg ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcaactggtg gagtctgggg gaggcttggt
      181 ccagcctgga gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagtta
      241 cgacatgacc tgggtccgcc aggctccggg aaaggggctg gagtgggtct catatattag
      301 ttacactggt aaaaccatat actactctga ctccgtgaag ggccgattca ccatctccag
      361 agacaacgcc aagaactctc tgtctctgca aatgagcagc ctgagagccg aggacacggc
      421 cgtgtattat tgttctagag cggcttacga acatgatgac ggttactatt acgtcggcag
      481 gttttttgac tgctggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001839             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20058:11602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001839
VERSION     KCXD01001839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20058:11602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60321.1"
                     /translation="CARGRSGGVWPNSFDYW"
     D_segment       424..433
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          115 a          131 c          144 g           98 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca tagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagtt ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac accttcaccg atttatccat gcactgggtg cgacaggccc
      241 caggaaaagg gcttgagtgg atgggaagtg ttgatcctgt atatggtgaa ataattgtcg
      301 cagagaattt ccaggacaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggaactgag cagcctggaa tctgaggaca cggccgtgta ttactgtgcg agagggagga
      421 gtggtggtgt ctggccgaac tcctttgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01001840             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9880:11466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001840
VERSION     KCXD01001840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9880:11466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60322.1"
                     /translation="CARWSAANFDYW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           92 a          135 c          133 g          100 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga agcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc aacagtggtt atggctggaa ctgggtccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtgtctct atgatagtag tgggaacacg tactacaacc cctccctcaa
      301 gagtcgcgtc accatttcaa aagacacgtc caaaaaccag ttctccctga acctgaggtc
      361 tatgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001841             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18771:20204
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001841
VERSION     KCXD01001841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18771:20204"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..278
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60323.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       289..294
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           77 a           83 c          106 g           77 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagccggg ggggtccctg agactctcct gtgcagtctc
       61 tgggttcacc ttcagtggct ctggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggaatgggtg gcggttatat cgaatgatgg aactaacaaa tactacgcag actctctgaa
      181 ggaccgattt agtatctcca gagagaattc caagaacatg ctatatcttc aaatgaacaa
      241 cctgaaactg gaggacacgg ccgtctatta ctgcgcgaca gatgcgtttg gtagcgggat
      301 tgactactgg ggccggggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001842             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:25359:11486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001842
VERSION     KCXD01001842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:25359:11486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..516
     V_segment       138..429
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60324.1"
                     /translation="CVRDIPYYNFWSGYDSGLDAW"
     D_segment       440..456
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..516
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          110 a          123 c          157 g          128 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tatttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ccggattcat cttcagtgac cactacatgg
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ctcacgtgtt actaatgatg
      301 gtggtagcac atggtacgca gactccgtga aggacagatt caccatctcc agagagaacg
      361 ccgagaacac cctttatctt caaatgaaaa gcctgagagc tgaggacacg gctgtctatt
      421 tttgtgtgag agatattccg tattacaatt tttggagtgg ctatgactcc ggtttggatg
      481 cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001843             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18726:12569
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001843
VERSION     KCXD01001843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18726:12569"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60325.1"
                     /translation="CARYEGEYSDYYFDYW"
     D_segment       403..418
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          131 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcttc aatagctact ggaactggac ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggtct atctatggtg caaccgggag caccggctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga cctctgtgac
      361 cgccgcggac accgccgtgt attattgtgc gagatatgag ggtgaataca gtgactacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001844             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4412:16660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001844
VERSION     KCXD01001844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4412:16660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..243
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <237..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60326.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       258..269
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       270..318
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           74 a           84 c           95 g           67 t
ORIGIN      
        1 acatgggggc ctcagtgaag gtctcctgca aggtttccgg aagaaccttc accgaattat
       61 ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtgggtggga agtgttgatc
      121 ctgaatatgg tgaaatgatg ttccagggca gagtcaccat gaccgaggac acgtctacag
      181 acacagccta catggagctg agcagcctga gatctgagga cacggccgtc tattactgtg
      241 cgattggccc tagtggcagc tggaacgact ggtccttcga catttgggga cctggcaccc
      301 caatcaccgt ctcctcagcc
//
LOCUS       KCXD01001845             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15229:5307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001845
VERSION     KCXD01001845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15229:5307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60327.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          112 a          122 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 ctatattact gtactagaaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001846             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23513:19986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001846
VERSION     KCXD01001846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23513:19986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..476
     V_segment       113..406
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60328.1"
                     /translation="CARVRLTVTTLYFDSW"
     D_segment       415..426
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           94 a          149 c          130 g          105 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcacggac atcctgttcc agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca
      121 gctgcaggag tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc
      181 tgtctctggt tactccgtca gcagtaacta ctggagctgg atccgccagc ccccagggaa
      241 gggaccggag tgcatcgggt ttatctctgg tagtggtggg accacctact acaacccctc
      301 cctcaagagt cgagtcacca tttcaacaga cacgtccaag aaccagttgt ccctgcagct
      361 gggctctgtg accgccgcag acacggccgt ttattactgt gcgagagtcc gacttacagt
      421 aactaccctc tactttgact cctggggcca gggagtccag gtcaccgtct cctcagcc
//
LOCUS       KCXD01001847             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15934:18774
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001847
VERSION     KCXD01001847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15934:18774"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60329.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       438..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          110 a          137 c          150 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actgaaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgcgaggtgc agctggtgga gtctgggggc ggcctggcaa
      181 agcctggggg agccctgagc ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga atgggtctca gctattagta
      301 gtggtggcac cacatactac gcagcctccg tgaagggccg attcaccgtc tccagagaca
      361 actcaaagaa cacactctcc ctacaaatga acagcctgag aactgaggac acggccgtgt
      421 tttactgtgc gaaagccgat acagctacac catactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01001848             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14692:11773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001848
VERSION     KCXD01001848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14692:11773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60330.1"
                     /translation="CARSPSGSWLYWYFDFW"
     D_segment       421..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          114 a          148 c          130 g           97 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaaag tttccggata caccttcacc gaattttcca tgcactggct acgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgatcctg cttttggtga aatgatacac
      301 gcagagaaat tccagaacag agtcaccctg accgaggaca cctctacaga cacagcctac
      361 atggagctga ctagcctgag atctgaggac tcggccgtgt attactgtgc gcgctcaccc
      421 agcggcagct ggctatactg gtacttcgat ttctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01001849             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22617:5162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001849
VERSION     KCXD01001849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22617:5162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60331.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       451..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          115 c          152 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctgttttaa gaggtatcca gtgtgaggta cagctggtgg agtctggcgg agacttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatggaa gtaagacata ctacgcaaac tctgtgaagg accgattcac catattaaga
      361 gacaattcca agagcatgct ctatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga cgatatggga agtggctttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001850             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14011:22365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001850
VERSION     KCXD01001850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14011:22365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..475
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60332.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       409..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           98 a          138 c          132 g          109 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag
      121 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct
      181 gtctctggtg actccatcag cagtagctac tggaactgga tccgccagcc cccagggaag
      241 ggactggagt ggattgggta tatctctggc gcttatggga gcaccagcta caacccctcc
      301 ctcaagagtc gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg
      361 agttctgtga ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc
      421 attaactacc actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001851             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10628:7819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001851
VERSION     KCXD01001851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10628:7819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60333.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       428..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          116 a          135 c          144 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa aaaccttcac tgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatctt gcatatgatg aaataatgga
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cggcgggcct
      421 tgggggatat ttactgcata ctgaatactt cgagttctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01001852             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6917:17999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001852
VERSION     KCXD01001852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6917:17999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60334.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          110 a          124 c          154 g          127 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcctggcaa
      181 agcccggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgaac aggggctgga gtggatctca gctattgata
      301 gtgctggtac tagtaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001853             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8846:8791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001853
VERSION     KCXD01001853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8846:8791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60335.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          121 a          141 c          136 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgagtt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatttctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01001854             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11386:7728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001854
VERSION     KCXD01001854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11386:7728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60336.1"
                     /translation="CAGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          106 a          124 c          153 g          108 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaaatgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcagctctt aattatgatg
      301 gggatagtac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgcaca gcctgagaga agatgacacg gccgtttatt
      421 tctgtgcggg cggggcgtac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01001855             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:24805:8042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001855
VERSION     KCXD01001855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:24805:8042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60337.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       409..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          138 c          127 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctttt ggatctggat ccgccagccc ccagggaagg gcctggagtg
      241 gatagggtct atctatggtg ctactgggag caccttttac gacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccaattttcc ctgaagctgg actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatagc gatactgata gttattacta
      421 ctttgactac tggggccagg gagtccgggt caccgtctcc tcagcc
//
LOCUS       KCXD01001856             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9871:16337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001856
VERSION     KCXD01001856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9871:16337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..434
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60338.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..450
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          120 c          157 g          120 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc cagaattccc aggtgtttct gttcggcgat
       61 cagcacaaaa cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc
      121 ttttgaaagg tgtccagtgt gaggtgaagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgcgcag cctctggatt caggttcaat tattactaca
      241 tgagctgggt ccgccaggct ccagggaagg ggctggagtg gatctcaggt attagtagtg
      301 gtggggaaag cacatactct gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaagaa cacactatat cttcaaatgg acagcctgag aactgaggac acggctgtct
      421 atttctgtgt gagagatcga cgtgtacagt cgttatcctg gttcgatgtc tggggcccgg
      481 gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001857             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21960:13128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001857
VERSION     KCXD01001857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21960:13128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60339.1"
                     /translation="CARGIDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          115 a          115 c          151 g          131 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agttggtgga gtctggggga ggattggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtagctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtgtca ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 atgccaagaa ctccgtgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtgc aagggggata gataactacc actttagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001858             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:6404:11784
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001858
VERSION     KCXD01001858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:6404:11784"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60340.1"
                     /translation="CARDEGDVSGYRFGYW"
     D_segment       434..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          114 c          159 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagt tggtggcgtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgaaactc tcctgtgcag cctctggatt caccttcagt agctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcgtttg
      301 atggaagtaa gaaatactac gcagactcta tgaaggaccg attcaccatc tctagagaca
      361 attccaagaa catgctatat cttcaactga acaacctgag attggaggac acggccatgt
      421 attactgtgc gagggatgag ggggacgtta gcgggtaccg atttggctac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001859             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10370:4102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001859
VERSION     KCXD01001859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10370:4102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..506
     V_segment       136..429
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60341.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       452..459
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>510
                     /gene="IGHG"
BASE COUNT          104 a          128 c          157 g          121 t
ORIGIN      
        1 acatggggct gagacaggag ccttagccct ggattccaag aacttccact ttgggatcag
       61 ctctgaacac agaggaccat ggagttgggg ctgagctggg ttttccttgt tgctatttta
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt ccagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct ttggtgatta tggcatgcac
      241 tgggtccgcc aggctccggg aaagggactg gagtggatct catccattag gaacactggt
      301 aaaatcgtat actacgctga ctccgtgaag ggccgattca ccatctccag agacaacgcc
      361 aagaactcgc tgtctctgcg aatgagcagc ctgagagccg aggacacggc cgtgtattac
      421 tgtactagaa ttggcgtcgg atctctggca acggctggtg actattttga ccactggggc
      481 cagggagtcc tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01001860             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10642:13452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001860
VERSION     KCXD01001860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10642:13452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60342.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          140 c          128 g           96 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ttggtacagt ctggggttga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag tcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001861             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18795:14732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001861
VERSION     KCXD01001861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18795:14732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60343.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          126 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agtctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccaccaga ctccagggaa gggactggag tggatctcag tgattaacag
      301 tggtggagat accacacact atgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccagg aacacactgt ctcttcaaat ggacggcctg agacctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001862             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23607:17888
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001862
VERSION     KCXD01001862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23607:17888"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60344.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          142 c          144 g           98 t
ORIGIN      
        1 acatgggggg atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggaat tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001863             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23771:20479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001863
VERSION     KCXD01001863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23771:20479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60345.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          111 a          116 c          152 g          124 t
ORIGIN      
        1 acatggggag ctctgggagc ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagtctctgg attcaccttc aggaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ttgatggaat taagagttat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa gaacatgcta aatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01001864             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14344:13329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001864
VERSION     KCXD01001864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14344:13329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60346.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          117 a          145 c          137 g           94 t
ORIGIN      
        1 acatggggaa catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgacgtgaag aagcctgggg cctctgtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgagtta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttc agtggatggg aagtgttgat cctgcatatg gtgaaatgat
      301 aaacacagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtctatttct gtgcgagtgg
      421 ccctagcggc agctggaacg gctggtactt cgatatctgg ggccctggca cccctatcac
      481 cgtctcctca acc
//
LOCUS       KCXD01001865             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:27023:13852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001865
VERSION     KCXD01001865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:27023:13852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..468
     V_segment       87..379
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60347.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       394..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          100 a          116 c          139 g          115 t
ORIGIN      
        1 acatggggac tgaacacaga ggacccacca tggagttggg gctgagctgg gttttccttg
       61 ttgctatttt aaaaggtgtc cagtgtgagg tgcaactggt ggagtctggg ggaggcttgg
      121 tccagcctgg agggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagtt
      181 acgacatgac ctgggtccgc caggctccgg gaaaggggct ggagtgggtc tcatatatta
      241 gttacactgg taaaaccata tactactctg actccgtgaa gggccgattc accatctcca
      301 gagacaacgc caagaactct ctgtctctgc aaatgagcag cctgagagcc gaggacacgg
      361 ccgtgtatta ttgttctaga gcggcttacg aacatgatga cggttactat tacgtcggca
      421 ggttttttga ctgctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001866             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12201:15051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001866
VERSION     KCXD01001866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12201:15051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60348.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       432..436
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          122 c          158 g          114 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactcaacac agaacatacc atggagtatg tgctgagttg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcaa cttcaattac tactacatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt aacagtggtg
      301 gggatagcac atactatgcg gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag agtggtgggt ggtgccgcag gatacttcga cttctggggc cagggcgccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001867             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:23102:19081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001867
VERSION     KCXD01001867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:23102:19081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60349.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          124 c          157 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga cgcaccatgg agtctgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatatt
      241 ggatgaactg ggtccgccag gctccagaga aggggctgga gtgggtctca gctattacta
      301 gtggtgggga aagtacacat tacgcagact ccgtgaaggg tcgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tggacagcct tagagcggag gacacggcca
      421 tatattactg tgcgaacgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001868             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13300:15267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001868
VERSION     KCXD01001868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13300:15267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60350.1"
                     /translation="CAIGPSGSWNDWSLDIW"
     D_segment       416..427
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          140 c          135 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaacttcag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gtatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaattgag
      361 cagcctgaga tctgaggaca cggccgtgta ttactgtgcg attggcccca gtggcagctg
      421 gaacgactgg tccctcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01001869             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23326:9362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001869
VERSION     KCXD01001869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23326:9362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..465
     V_segment       87..379
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60351.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       385..392
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..465
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           96 a          124 c          147 g          100 t
ORIGIN      
        1 acatggggct gggaacacag ctcatcacca tggacttgac ctggaggctc ctctttgtgg
       61 tggcagcagc tacaggtgcc cagtcccagg tccagctggt gcagtccggg gctgaggtga
      121 ggaagcctgg ggcctcagtg aagctctcct gcaaggcttc tggatacacg ttcagcatct
      181 atgccatcag ttgggtgcga caggcccctg gacaagggct tgagtggatg ggagggatca
      241 tccctcttgt tgatgtaaca aactacgcac agaagttcca gggcagagtc acgattaccg
      301 cggacacgtc cacaagcaca gcctacatgg agctgagcag cctgagatct gaggacacgg
      361 ccgtgtattt ctgtgcgagg ggagattgta ctgatactga ctgctcttcc gcggggggcg
      421 cctttgattt ctggggccaa ggactcaggg tcaccgtctc ttcagcc
//
LOCUS       KCXD01001870             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16458:19227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001870
VERSION     KCXD01001870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16458:19227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60352.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       402..412
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           95 a          140 c          136 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actgctgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cagtaactac tggagctgga tccgccagtc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtggtggga acaccgtcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagatctc cctgaaagtg acctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgacagccgg atatagcagc agggaaagct
      421 tctacggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001871             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15054:8991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001871
VERSION     KCXD01001871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15054:8991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60353.1"
                     /translation="CARPRNIGVRYLGYW"
     D_segment       399..404
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           92 a          136 c          138 g           97 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggg ctggtggagc cttcggagac cctgtccctc acctgcgctg tctctggggg
      181 ctccatcagt ggttactact ggaactggat ccgccaacct ccagggaagg ggctggagtg
      241 gattggatat atcggtggta gtagtgggat cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtat actattgtgc gagaccaagg aacatagggg tgcgatacct
      421 gggctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001872             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23916:7417
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001872
VERSION     KCXD01001872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23916:7417"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..328
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60354.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       278..283
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>332
                     /gene="IGHG"
BASE COUNT           73 a           80 c           97 g           82 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct
       61 tcagtatctt tggcatccac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
      121 cagttatttc atatgatgaa attacgaaat actacgcaga ctctgcgaag gaccgattca
      181 ccatctccag agacaattcc aagaatgtgg tatatcttca aatgaacagc ctgaaattgg
      241 aggacacggc cgtgtatttc tgtgcgagag gggattttgg taatggcgtc gactactggg
      301 gccagggagt cctggtcacc gtctcctctg cc
//
LOCUS       KCXD01001873             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19917:7731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001873
VERSION     KCXD01001873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19917:7731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..522
     V_segment       141..433
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60355.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       448..467
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       480..522
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT          112 a          130 c          154 g          128 t
ORIGIN      
        1 acatggggct gagagaggag ccttagccct ggatttcaag gcacttccac ctggggatca
       61 gcactgaaca cagaggaccc accatggagt tggggctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagtgt gaggtgcaac tggtggagtc tgggggaggc ttggtccagc
      181 ctggagggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttacgaca
      241 tgacctgggt ccgccaggct ccgggaaagg gtctggagtg ggtctcatat attagttaca
      301 ctggtaaaac catatactac tctgactccg tgaagggccg attcaccatc tccagagaca
      361 acgtcaagaa ctctctgtct ctgcaaatga gcagcctgag agccgaggac acggccgtgt
      421 attattgttc tagagcggct tacgaacatg atgacggtta ctattacgtc ggcaggtttt
      481 ttgactgctg gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001874             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22453:14655
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001874
VERSION     KCXD01001874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22453:14655"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60356.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       451..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          117 c          152 g          130 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatgttaaa aggtgtccag tgtgtggagc agctggtgga atctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga ctgggtatca ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatg tccagagaca
      361 atgccaagaa ctccgtgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtgc aagggggata gataactacc actatagtga tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001875             276 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24515:18922
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001875
VERSION     KCXD01001875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 276)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 276)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24515:18922"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..274
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..274
     V_segment       8..213
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <205..>243
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60357.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       226..232
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       233..274
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        275..>276
                     /gene="IGHG"
BASE COUNT           75 a           60 c           78 g           63 t
ORIGIN      
        1 acatggggta actatggcat acactgggtc cgccaggctc cagggaaggg gctggagtgg
       61 gtggcagtta tatcgtctga tggaagtaag acatactacg caaactctgt gaaggaccga
      121 ttcaccatat taagagacaa ttccaagaat atgctatatc ttcaaatgaa caacctgaaa
      181 ttggaggaca cggccgtcta ttactgtgcg agagacgatt tgggaagtgg ctttgactac
      241 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001876             429 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:24078:7568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001876
VERSION     KCXD01001876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 429)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 429)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:24078:7568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    58..427
                     /note="immunoglobulin heavy chain variable region"
     V_region        58..427
     V_segment       58..351
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <343..>396
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60358.1"
                     /translation="CAREYCTTHDCAGFFDYW"
     D_segment       352..363
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       384..427
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        428..>429
                     /gene="IGHG"
BASE COUNT           91 a          112 c          128 g           98 t
ORIGIN      
        1 acatggggga cctggaggct cctctttgtg gtggcagcag ctacaggtgt ccagtcccag
       61 gtccagttgg tgcagtccgg ggctgaggtc aagaagcctg gggccgcagt gaaggtttcc
      121 tgcaaggctt ctggattcac cctcgacaac tatggtatca actgggtgcg acaggcccct
      181 ggacaagggc ttgagtggat gggcgtgatc atcccccatg ttggtataat aaattacggt
      241 gagcggttcc aggacagagt cacgattagc gcggacacgt ccatgaatat agcctacatg
      301 gacctgacca gcctgaaatc cgacgacacg gccatctatt tctgtgcgag agaatactgt
      361 actactcatg attgcgccgg cttctttgac tactggggcc agggagtcct ggtcaccgtc
      421 tcttcagcc
//
LOCUS       KCXD01001877             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:11575:2980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001877
VERSION     KCXD01001877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:11575:2980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60359.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..445
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          112 c          148 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcatg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa aatctacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaatac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccctgtatt
      421 actgtgcgag aggggaatac agtaattcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001878             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12353:15536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001878
VERSION     KCXD01001878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12353:15536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..420
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <412..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60360.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       421..426
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          115 a          143 c          133 g           92 t
ORIGIN      
        1 acatgggggg agcatcacac aaccaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggctc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactccgagg tccagctggt acagtctggg gctgaggtga agaagcctgg ggcctccgtg
      181 aaaatctcct gccaggcttc tggatacacc ttaaccgacc actacctgca ctgggtgcga
      241 caggctcctg gaaaaggact tgagtggatg ggaggtgttc atcctgaata tggtaaagta
      301 gactacacac agaagttccg agacagagtc accatcaccg cggacatgtc gacagagaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtttatta ctgtgtgaca
      421 gtgggtccct accattactt tgactactgg ggccagggag ccctggtcac cgtttcctca
      481 gcc
//
LOCUS       KCXD01001879             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20011:10279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001879
VERSION     KCXD01001879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20011:10279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60361.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          103 a          125 c          161 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc ggctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattagca
      301 gtggtgggga tgacacatac tatgcggact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaccacactg tatcttcaaa tggacagcct gacagctgag gacacggctg
      421 tctattactg tgtgagagat cgacgtgtac agtcgttgtc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001880             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16111:4050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001880
VERSION     KCXD01001880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16111:4050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60362.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       459..466
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          113 a          132 c          158 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggtcc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggtggtag aaatagaaac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacagcct gagacctgag gacacggccg
      421 tgtattactg tgcgtcgaac ctgcgtggaa acacctacac ttactggcgg tcttttgact
      481 cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001881             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20534:12201
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001881
VERSION     KCXD01001881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20534:12201"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60363.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       403..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          138 c          138 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggagg
      181 ctctgtcagc agtagcacct ggtggaactg gatccgccag cccccaggga aaggactgga
      241 atggattggc tatatcagtg gtgatagtgg taggaactcc tacaacccct ccctcaagag
      301 tcgaatcacc atttcaacag acacgtccaa gaaccagttc tccctgaggc tggggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaggt tcctatagtg gcagttatta
      421 cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001882             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23881:10445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001882
VERSION     KCXD01001882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23881:10445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60364.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          144 c          136 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccat
      121 tctgaggtcc agctggtgca atctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctttatatgg tgaaatgata
      301 cacacagaac agttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagtggc
      421 cctagcggca gctggaacga ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01001883             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15229:4899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001883
VERSION     KCXD01001883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15229:4899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60365.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       445..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          115 a          112 c          153 g          118 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca atcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagctttggc
      241 atacactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcctat
      301 gatgaaacta agaaatacta cgcagactct gtgagggacc gattccccat ctccagagac
      361 aattccaaaa acatgatata tcttcaaatg aacaacctga aattggagga cacggccgta
      421 tattattgtg tgagagatgt caggggaacg gggtttgact actggggccg gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001884             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20036:5146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001884
VERSION     KCXD01001884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20036:5146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..510
     V_segment       135..426
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60366.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       462..468
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          123 c          158 g          117 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtat ttctgttcgg cgatcagcac
       61 taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg cgcctggtgc agtctggggg cggcctgaca aagccggggg
      181 ggtccctgag actctcctgt gcagcctccg gattcacctt cagtgactac tatatggact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtctc acgaatcaat catgatggca
      301 caagcacatg gtacgcagac tccgtgaagg gcagatttac catttccaga gagaatgcca
      361 agaacacact gtttctgcaa atggacagcc tgagaagtga ggacacagcc gtatattact
      421 gtgcgagaga gcggtttggg ggaattgggg taattatctt caactggatc gatgtctggg
      481 gtccgggagt cctggtcacc gtcccctcag cc
//
LOCUS       KCXD01001885             404 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:7446:3253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001885
VERSION     KCXD01001885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 404)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 404)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:7446:3253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    39..402
                     /note="immunoglobulin heavy chain variable region"
     V_region        39..402
     V_segment       39..332
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <324..>371
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60367.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       342..348
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       358..402
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        403..>404
                     /gene="IGHG"
BASE COUNT           82 a           97 c          129 g           96 t
ORIGIN      
        1 acatggggtt tgttgctctt ttgaaaggtg tccagtgtga ggtgcagttg gtggagtctg
       61 ggggcggctt ggcaaagccg ggggggtccc tgagactctc ctgcgcagtc tctggattca
      121 gtttcagtca ctacttcatg agctgggtcc gccaggctcc agggaaggga ctggagtgga
      181 tctcagggat taacagtggt ggagatacca cacactatgc agactccgtg aagggcagat
      241 tcaccatgtc cagagagaac gccaagaaca cactgtccct tcaaatggac ggcctgagag
      301 ctgaagactc ggctgtctat tattgtgcga gagatcgacg tgtacagtcg ttatcctggt
      361 tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001886             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:23740:15123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001886
VERSION     KCXD01001886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:23740:15123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60368.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       443..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          112 c          155 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgtta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aattatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcagtt atgtcgtctg
      301 atggaactaa gacattctac gcagactctg tgaaggtccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acagcctgaa atcggaggac acggccgtgt
      421 attactgtgg gagagatgat aatggggtga ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtcgc ctcagcc
//
LOCUS       KCXD01001887             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:24822:5641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001887
VERSION     KCXD01001887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:24822:5641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60369.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       260..272
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           81 a           77 c           83 g           78 t
ORIGIN      
        1 acatgggggg tccctgaggc tctcctgtgc agcctctgga ttcaccttca gtaattatgg
       61 cttccactgg gtccgccagg ctccagtgaa ggggctggag tgggttgcag ttatatcgta
      121 tgatgaaaat gtgaaattct acgcagactc tgtaaaggac cgattcacca tctccagaga
      181 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      241 gtattactgt acgagagggg aatacagtaa ctctattgac tactggggcc agggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001888             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:16332:8697
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001888
VERSION     KCXD01001888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:16332:8697"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60370.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          144 c          142 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctggggcc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg ctgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt gtatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01001889             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:11323:11305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001889
VERSION     KCXD01001889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:11323:11305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..332
     V_segment       8..258
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60371.1"
                     /translation="CASGPSGTWNDWYFDIW"
     D_segment       271..283
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..332
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           81 a           92 c           94 g           67 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caaggtttcc ggatacacct tcaccgaact
       61 gtccatacac tgggtgcgac aggcccctgg aaaagggctt gactggatgg gaagtgttga
      121 tcctctatat ggtgaaatga tacacacaga gaagttccag ggcagagtca ccatgaccga
      181 ggacacgtct acagacacag cctacatgga gctgaccagc ctgagatctg aggacacggc
      241 cgtgtattat tgtgcgagtg gccctagcgg cacctggaac gactggtact tcgatatctg
      301 gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01001890             307 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17916:19611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001890
VERSION     KCXD01001890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 307)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17916:19611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..305
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..305
     V_segment       8..244
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <236..>274
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60372.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       250..255
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..305
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        306..>307
                     /gene="IGHG"
BASE COUNT           69 a           75 c           89 g           74 t
ORIGIN      
        1 acatgggctc tcctgtgcag cctctggatt ctccttcagt atctctggca tgcactgggt
       61 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt aaatcgtttg atggaagtaa
      121 gaagttctac gcagactctg tgaaggaccg attcaccatc tccagagaca attccaagaa
      181 catgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt attactgtgt
      241 gagagatgcc tacgggggcg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      301 ctcagcc
//
LOCUS       KCXD01001891             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12678:20224
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001891
VERSION     KCXD01001891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12678:20224"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60373.1"
                     /translation="CAIGPSGRWNGWSFDIW"
     D_segment       413..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          107 a          145 c          137 g           90 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccctca ccgaagtgtc cactcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtccacaga cacagcctac atggaactga
      361 gcagcctaag atctgaggac acggccgtgt attactgtgc gattggccct tccggcaggt
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01001892             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17415:4265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001892
VERSION     KCXD01001892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17415:4265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60374.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       447..457
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          109 a          131 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggtcc
      181 agcctggggg gtccctgaga ctctcctgta cagccactgg attcaccttc agtagttttg
      241 gcatgagctg ggtccgccag cctccaggga aggggctggg gtgggtctca tacattagta
      301 atagtggtag tagcacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct gacagctgag gacacggccg
      421 tgtatcactg tgcgaaacat cgtttcagca gctggtcgta tttccttgac ttctggggcc
      481 agggaatcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01001893             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22147:8484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001893
VERSION     KCXD01001893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22147:8484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..477
     V_segment       103..410
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60375.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       416..423
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>483
                     /gene="IGHG"
BASE COUNT           87 a          144 c          139 g          113 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggag
      241 tggattgggt gtatctttgg tggtggtatc tttggtggtg gaagtaacac ctactacagc
      301 ccctccctca agagtcgagt caccctgtca gtagacgcgt ccaagaccca gctctccctg
      361 aaactgacgt ctgtaaccgc cgcggacacg gccgtgtatt tctgtgcgag cgctgatagc
      421 ggttatcctc cctacttctt tgacatctgg ggccagggag tcctggtcac cgtctcccca
      481 gcc
//
LOCUS       KCXD01001894             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15595:16684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001894
VERSION     KCXD01001894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15595:16684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60376.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          112 a          123 c          147 g          108 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagtgtcac cgaattatcg cttcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aagaaattca
      301 cggagaggag ttccaggaca gagtcaccat gaccgaggac ccgtctacag acactgccta
      361 catggagttg agcaacctga gatctgagga cacggccgtg tattattgtg cgagtgggtt
      421 tagtatctgg ttattttatg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01001895             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16233:6464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001895
VERSION     KCXD01001895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16233:6464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60377.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       402..416
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          127 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtga
      181 ctctatcagc agtagtcact ggtggagctg gatccgccag cccccaggga aaggcctgga
      241 gtggattggc tatatcagtg gtagtggtga taacacctac tacaacccct ccctcaagaa
      301 tcgagtcacc ttttcaacag tcacgtccaa gaaccagttc tcccttaagc tgagctctgt
      361 gaccgccgcg gacacggcca tgtattactg ttcgagggtg cgtggataca actacatttt
      421 atttgactcc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001896             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13029:9265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001896
VERSION     KCXD01001896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13029:9265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60378.1"
                     /translation="CARGRSGGVWPNYFDYW"
     D_segment       428..437
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          110 a          134 c          147 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa gagggcttga gtggatggga ggtgttgatc ctgtgtatgg tgaaattatt
      301 gtcgcagaga atttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct ggaatctgcg gacacggcca tctattactg tgcgagaggg
      421 aggagtggtg gtgtctggcc gaactacttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01001897             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:4150:10989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001897
VERSION     KCXD01001897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:4150:10989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..431
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60379.1"
                     /translation="CVRGMDNYHFINTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          114 a          119 c          145 g          132 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggaggagt ctgggggagg cttggtacag
      181 cctggggcgt ccctgagact ctcctgtgca gcctctgaat tcaccttcag tggctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctggagt gggtttcagg tattaacatt
      301 ggcgatgacc catactaccc agactctgtg aagggtcgat tcaccatctc cagagacaat
      361 gccaagaact ccttgtatct tcaaatgacc aacctgagag ttgaggacac tgctgtgtat
      421 tattgtgtaa gggggatgga taactaccac ttcattaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001898             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20690:15344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001898
VERSION     KCXD01001898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20690:15344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60380.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       444..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..513
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          122 a          120 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag tctccagggg aggggctgga atgggtggca cttatatcgt
      301 atgatggaac taagaaatat tacgcagact ctatgaagga ccgagtcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagta agcggtataa ctgaaagttc cgttgaatac ttcgagttct
      481 ggggcaaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01001899             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14913:7394
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001899
VERSION     KCXD01001899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14913:7394"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60381.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       432..438
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT           98 a          123 c          158 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tgaagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggtttcagc ttcagtttct tctatatgac
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtt tcaggtattg acactggtgg
      301 gggtgacacc ttctatgcag actccgtgaa gggccgattc accatctcca gagaaaacgc
      361 caagaagaca ctatatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gtagtgggtg gtgccgccgg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001900             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15309:3880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001900
VERSION     KCXD01001900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15309:3880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60382.1"
                     /translation="CVRDAFGSGFDVW"
     D_segment       417..422
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          104 a          103 c          149 g          118 t
ORIGIN      
        1 acatggggga agtccacagt gttccattcg gtgatcagca cagaacacag aggactcacc
       61 atgaagtttg ggctgagctg ggttttcctt gttgctattt taagaggtgt ccagtgtgag
      121 gtgcagctgg tggagtctgg aggaggcttg gttcagcctg gggggtccct gagactctcc
      181 tgtgcagcct ctggattcac cttcagtacc tatggcatac actgggtccg ccaggctcca
      241 gggaaggggc tggagtgggt ggcagtgata tcgtatgatg aaaataagaa gtactacgca
      301 gactctgtga agggccgatt caccgtctcc agagacaatt ccaagaatat gatatatgtt
      361 caaatgaaca acctgaaatt ggaggacacg gccgtgtatt tctgtgtgag agatgcattt
      421 gggtcggggt tcgatgtctg gggcccggga gtcctggtcg ccgtctcctc agcc
//
LOCUS       KCXD01001901             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16565:14535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001901
VERSION     KCXD01001901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16565:14535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60383.1"
                     /translation="CARDGIAAAGVDYW"
     D_segment       403..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           83 a          139 c          142 g           98 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgctagag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatcggtgg tcataatggg aacacctact acaacccctc cctcacgagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagtt gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgcgcgatg ggatagcggc ggcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001902             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:8853:6334
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001902
VERSION     KCXD01001902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:8853:6334"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60384.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          116 c          149 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 caacctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa gtaacaaata ctacgcaacc tctgtgaaga gccgattcac catctccaga
      361 gacaattcca agagcatact atatcttcaa atgaacaact tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatattggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001903             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5284:12463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001903
VERSION     KCXD01001903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5284:12463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60385.1"
                     /translation="CARYDADDYGYYFLDYW"
     D_segment       406..415
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          140 c          131 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc atttgcgctg tctctggggg
      181 ctccatcacc agtagcttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atctctggtg ctactgggag taccagctac aatccctccc tcaagagtcg
      301 agtcaccatc tcaacagaca cgtccaacaa ccacttttcc ctgaggctga actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gcggatgact acggttatta
      421 tttccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001904             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20769:19257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001904
VERSION     KCXD01001904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20769:19257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60386.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          142 c          126 g           99 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatcc ctgcactggg ttcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag ttttaatcct atatatggtg aaattttaca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01001905             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17060:4210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001905
VERSION     KCXD01001905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17060:4210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60387.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       418..427
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          118 a          135 c          133 g          109 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agttggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccttc gacaactatg gtatcaactg ggtgcgacag
      241 gcccctggac aggggcttga gtggatggga gtaaccatcc cccttgttgg tataatcaac
      301 tacagagaca acgtccagga cagagtcacc atttccgcgg acacgtccac aaacacagcc
      361 tacatggaga taaacagcct gagatctgac gacacggcca tctattactg tgcgagagaa
      421 tattgtactt ctactgattg cgccggattt tttgactttt ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01001906             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17109:11110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001906
VERSION     KCXD01001906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17109:11110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60388.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          143 c          148 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcag cgaattgtcc atgcactggg tacgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtggacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agcggctggt ccaacctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01001907             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9018:18223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001907
VERSION     KCXD01001907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9018:18223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60389.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          114 c          155 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggta cagctggtgg agtctggagg aggcttggtt
      181 cagcctcggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 tctgatggaa gtagcatata ctatgcagcc tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaatttga ggacacggcc
      421 gtgtattact gtgcgagaga tgtgtacggt agtgggttag actactgggg cctgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001908             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18735:20705
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001908
VERSION     KCXD01001908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18735:20705"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60390.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          104 a          127 c          154 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttaatggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagc tattaacgct
      301 ggtggcgata ccacatacta tggagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tatttctgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tccccgtctc ctcagcc
//
LOCUS       KCXD01001909             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15814:15693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001909
VERSION     KCXD01001909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15814:15693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60391.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          115 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 ctgatgaaga taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001910             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21728:10188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001910
VERSION     KCXD01001910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21728:10188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60392.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       420..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          116 a          138 c          139 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg atgcgacagg
      241 cccctggaaa agggcttgag tgggtggggg gtgttgatcc tgaatatggt gaaatgacac
      301 acgtagagaa attccagggc agagtcacct tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtatttctgt gcagccggat
      421 atagtggcag ctggaactcc tggtacttcg atttctgggg tcctggcacc gcaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001911             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15601:14918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001911
VERSION     KCXD01001911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15601:14918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60393.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       438..458
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          111 c          154 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagc tatggcataa
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gggaattgtt tcgtttgatg
      301 gaactaagag atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaagaatat gctatatctt caaatgaaca acctgaaaat cgaagacacg gccgtgtatt
      421 atagtacgag agtagactgt agtggtggtg tctgctactt tgaccactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001912             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18746:13113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001912
VERSION     KCXD01001912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18746:13113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60394.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       433..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          144 c          142 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tccccaacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggac ttgttgatcc tgtaaatggt gaactaatac
      301 acgcagacaa gttccagggc agagtcacca tgaccgaaga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg acatctgagg acacggccat ctactactgt gcgacaggga
      421 ggatcggtac cagtggctgg tctaacctct tcaatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01001913             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10362:7940
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001913
VERSION     KCXD01001913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10362:7940"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60395.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       407..428
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           96 a          142 c          134 g          115 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctatcagc agtactaaat ggtggagctg gatccgccag cccccaggga aagggctgga
      241 gtggattggg tatatcagtg gtagtagtgg taacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacgg acacgtccaa caaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tttattattg tgcgagatcc caatcctatt gtagtgggct
      421 ttactgcttc ggctactact actttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01001914             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14227:17196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001914
VERSION     KCXD01001914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14227:17196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60396.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       437..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          101 a          125 c          157 g          111 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacacacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccattgtgag gcgcacctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct aagactctcc tgtgaagcct ccgggttcac cttcagtgac cactgcatgc
      241 actgggtccg ccaggcttca gggagggggc tggagtgggt ctcaggtatt acttatactg
      301 gtgttaccac atggtacgca gactccgtga ggggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgtggg aggaaggcgg cacgtggacc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001915             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:3125:10860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001915
VERSION     KCXD01001915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:3125:10860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60397.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       445..457
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          111 c          157 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtaac
      241 ggcatgcact gggtccgcca ggttccaggg aaggggctgg agtgggtggc agtgacatcg
      301 tttgatgaaa gtaagaaata ctacgcagac tctgtgaagg accgattcac cgtctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga ctcttatgga agtggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001916             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:24339:14477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001916
VERSION     KCXD01001916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:24339:14477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60398.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          123 c          154 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc
      301 tgatggggat agcacatact atgcagactc catgaagggc agattcacta tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggccttcctg agagcagagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg atcaccgtct cctcagcc
//
LOCUS       KCXD01001917             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15019:20666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001917
VERSION     KCXD01001917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15019:20666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..495
     V_segment       135..425
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <417..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60399.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       428..443
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          122 c          156 g          115 t
ORIGIN      
        1 acatggggag aggagcccag cactggaagt ccacagtgtt ccattcggtg atcagcactg
       61 aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg caggtggtgg agtctggggg cggcttggca aagcctgggg
      181 gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat gctatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtctc agccattagt gttggtggta
      301 gtacatatta cgcagactcc gtgaggggcc gattcaccat ctccagagac aactcagaga
      361 acacgctctc cctgcaaatg aacagcctga gagctgagga cacggccgtg tattactgtg
      421 cgaaagggga tacagctaca gtttattacg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01001918             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18252:19378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001918
VERSION     KCXD01001918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18252:19378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60400.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..412
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           82 a          139 c          139 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agttcccaga tgggtcctgt cccaggtgcg gctgcaggag
      121 tcgggcccag gacttgtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggggctgg atccgccggc ccccagggga gggtctggag
      241 tggattgggt atatcagtgg gagtggtggg agttccgact acaagtcctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccacttct ccctgacgct gacctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtcc ggggcgtaac tatccactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001919             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13325:6884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001919
VERSION     KCXD01001919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13325:6884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60401.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          119 a          139 c          135 g           95 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac atcttaaccg agttatccat acactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaagtg ttgatcctca atatggtgaa atgatagacg
      301 cagagaaatt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagtctgaga tctgaggaca cggccgtgta ttactgtgcg acatcatcca
      421 gcggcacctg gctatactgg tacttcgatt tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01001920             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:2953:13275
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001920
VERSION     KCXD01001920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:2953:13275"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..522
     V_segment       141..434
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60402.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       444..450
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..522
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT          111 a          117 c          161 g          135 t
ORIGIN      
        1 acatgggggg ggagaggagc cacagccccg ggattcccag ctgtctccac ttggtcatga
       61 acactgaact cagaagacgc accatggagt ttgtgctgag tttgcttttc cttgttgctt
      121 ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc
      181 ctggggggtc cctgagactc tcttgtgtag tctctggatt ctccttcagt aactatgtta
      241 tgcattgggt ccgccaggct ccaggaaagg gtctggagtg ggtctcactt attagtggaa
      301 gtggtggtac cacagactac gcagactctg tgaagggccg attcaccctc tccagagaca
      361 acgccaagga atcgcttttt ctgcaaatga acagcctaag agccgaggac acggccgtgt
      421 attactgtgc tagaggcggg gaaatagtgg attcagagat tattgaggat tactacggtt
      481 tggatttctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01001921             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10717:17530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001921
VERSION     KCXD01001921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10717:17530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60403.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          138 c          125 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc aatagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggatat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001922             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8334:10954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001922
VERSION     KCXD01001922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8334:10954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60404.1"
                     /translation="CARVTGIDGTTVEYFDFW"
     D_segment       438..453
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..507
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          117 a          118 c          156 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttctcctt gtcgctattt
      121 taagaggtgt ccaatgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagagtctcc tgtgcggcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcatctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatgtt cagatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcaag agtaaccggt atagatggaa ctaccgttga atacttcgat ttctggggcc
      481 agggcgccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001923             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17705:13383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001923
VERSION     KCXD01001923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17705:13383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60405.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       432..444
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          111 a          115 c          148 g          117 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggta cagctggtgg agtctggggg aggcttggtt cgccctgggg
      181 ggtccctgag actctcctgt gcagcctctg gatttacctt cagtagcttt ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttttgtcg tctgatggag
      301 gttacaaata ccacgcagac tctaagaagg accgattcac catctccaga gacaattcca
      361 gaaacatcct atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtgtattact
      421 gtgcgagagg ggaatacagt aactctattg actactgggg ccagggagtc ctggtcaccg
      481 tctcgtcagc c
//
LOCUS       KCXD01001924             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:26409:14804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001924
VERSION     KCXD01001924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:26409:14804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60406.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          144 c          133 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatccact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgaacagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 cctctcctca gcc
//
LOCUS       KCXD01001925             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15398:10872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001925
VERSION     KCXD01001925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15398:10872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..277
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..277
     V_segment       8..203
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60407.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       219..229
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       232..277
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        278..>284
                     /gene="IGHG"
BASE COUNT           66 a           69 c           84 g           65 t
ORIGIN      
        1 acatgggatc catgcactgg ctgcgacagg cccctggaaa agggcttgag tggttgggat
       61 gtgttgatta taaatatgat gaagaaatat acgcagacaa tttccagggc agagtcacca
      121 tgaccgagga cacgtccaca gacacagcct acatggagct gagcagcctg agatctgagg
      181 acacggccgt gtatttctgt gcggcgggcc ttgggggata tttactgctt actgaatatt
      241 tccagttctg gggccagggc gccctggtca ccgtctcttc cgcc
//
LOCUS       KCXD01001926             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23151:8554
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001926
VERSION     KCXD01001926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23151:8554"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60408.1"
                     /translation="CATHGGYSDIWTSLYNGLDSW"
     D_segment       425..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          122 a          147 c          140 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcca caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaagttaag aggcctgggg cctcagtgat
      181 ggtctcctgc caggtttccg ggtacaccgt caccgaaata tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgct cctgaaaaaa atgaattaat
      301 acacgcagac aagttccagg acagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtggcc ttacatctga ggacacggcc gtgtattact gtgcgaccca
      421 cggagggtat agcgacatct ggacctccct atataacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01001927             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15860:12564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001927
VERSION     KCXD01001927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15860:12564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..420
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60409.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       421..432
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          141 c          138 g          106 t
ORIGIN      
        1 acatggggag catcacaaaa caaccacatc cctcctctaa agaagcccct gggagcacag
       61 ctcatcacca tggactggac ctggaggctc ctctttgtgg tggcagcagc tgcaggtgtc
      121 cagtcccagg tccgcctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtttcct gcggggcttc tggattcacc ctcgacacct atggtatcaa ctgggtgcga
      241 caggcccctg gacaagggct tgagtggatg ggagtggtca tcccccttat tggtatcata
      301 aactacgcaa agaactctca gggcagactc acaataaccg cgaacacgtc cacaaataca
      361 gcctatttgg aactgagcag tctgagatct gaggacacgg ccatctatta ctgtgcgaga
      421 gaatactgta cttctagttc ttgcgccggg ttccttgact actggggcca gggagccctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001928             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19235:9552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001928
VERSION     KCXD01001928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19235:9552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60410.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          118 a          147 c          130 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggc agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagact tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga ccagcctaag atctgaggac acggccctct attactgtgc agtcgggtat
      421 agcggcagat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01001929             272 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24815:12988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001929
VERSION     KCXD01001929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 272)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 272)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24815:12988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..270
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..270
     V_segment       7..200
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <192..>239
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60411.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       204..211
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       226..270
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        271..>272
                     /gene="IGHG"
BASE COUNT           61 a           77 c           73 g           61 t
ORIGIN      
        1 acatggggaa ctggatccgc cagcccccag ggaagggact ggagtggatt gggtatatct
       61 ctggtgctta tgggagcacc agctacaacc cctccctcaa gagtcgagtc accatttcaa
      121 cagacacgtc caagaaccag ttttccctga ggctgagttc tgtgaccgcc gcggactccg
      181 ccgtgtatta ctgtgtgaga tatgaggatg aatccattaa ctaccacttt gactactggg
      241 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001930             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10279:18969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001930
VERSION     KCXD01001930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10279:18969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60412.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       439..445
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          120 c          155 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 caaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gaagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcagct tcagttatta ctacatgagc
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtgttaa tagtggtggg
      301 gaaagcacat actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaacacac tatatcttca aatggacagc ctgagaactg aggacacggc tgtctattac
      421 tgtgtgagag atcgacgtgt acagtcgtta tcctggttcg atgtctgggg cccgggagcc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001931             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22364:17508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001931
VERSION     KCXD01001931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22364:17508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..445
     V_segment       100..386
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60413.1"
                     /translation="CASSDYGWFDVW"
     D_segment       391..399
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..445
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           92 a          123 c          127 g          105 t
ORIGIN      
        1 acagggggtt ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggaatcg
      121 gacccaggag tagtgaagcc ttcggagacc ctgtccctca cctgcgttgt ctctggtggc
      181 gatagttata ggtggagctg gatccgccag cccccaggga agggactgga atggattggg
      241 tatatttatg gtagtattac ggacaccaac tacaacccct ccctcaaaag tcgagtcacc
      301 atttcaaaag acacgtccaa gaagcagttc tccttgaaac tgagctctgt gaccgtcgcg
      361 gacacggccg tgtatttctg tgcgagttca gactacggtt ggttcgatgt ctggggcccg
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001932             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6752:14525
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001932
VERSION     KCXD01001932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6752:14525"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60414.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcattcactg ggtccgccag actccaggga aggggctggg gtgggtggca gttatatcgt
      301 atgatgaaac taagacatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggtg tattttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001933             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20304:11267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001933
VERSION     KCXD01001933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20304:11267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60415.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          100 a          125 c          157 g          123 t
ORIGIN      
        1 atgggggctc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actacttcat
      241 gagttgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta tttccagtgg
      301 tggggatagc acatactctg cagactccgt gaagggcaga ttcaccattt ccagagagaa
      361 cgccaagacc acactgtatc ttcacatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgca agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001934             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:7579:20350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001934
VERSION     KCXD01001934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:7579:20350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..521
     V_segment       140..432
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60416.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       447..466
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       479..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          112 a          130 c          156 g          125 t
ORIGIN      
        1 acatgggggg agagaggagc cttagccctg gatttcaagg cacttccacc tggggatcag
       61 cactgaacac agaggaccca ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcaact ggtggagtct gggggaggct tggtccagcc
      181 tggagggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gttacgacat
      241 gacctgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagttacac
      301 tggtaaaacc atatactact ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tctctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttattgttct agagcggctt acgaacatga tgacggttac tattacgtcg gcaggttttt
      481 tgactgctgg ggccagggag ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001935             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10690:18180
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001935
VERSION     KCXD01001935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10690:18180"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60417.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       430..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          143 c          150 g           97 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccgctct
      121 gaggtccacc tggtgcagtc tggggctgag gtgaagcagc ctggggcctc agtgaaggtc
      181 tcctgtaagg tttccggata caccgtcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctgggaaag ggcttgagtg gatgggagtt gttgatcctg tcaatggtga agaaatatac
      301 gcagagaggt tccagggcag agtcaccatg accgaggaca cgtcgacaga cacagcctac
      361 atggacttga ccagtctcag atctgaggac acggccatct attactgtgc gacagggagg
      421 atcggtagta gcggctggtc cagcctcttc accggtttgg attcctgggg ccgaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01001936             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15039:13110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001936
VERSION     KCXD01001936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15039:13110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60418.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          109 a          121 c          160 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtccg gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattact gtactaggaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001937             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14966:16868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001937
VERSION     KCXD01001937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14966:16868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60419.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       439..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          110 a          118 c          149 g          119 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg ctgacagtta tatcgtatga
      301 tgagactaag aaatactacg cagactctgt gaagggccga ttcaccatct tcagagacaa
      361 ttccaaaaac atgctatatc ttcaaatgaa caacctgaaa ttggaggacg cggccgtgta
      421 ttactgtgcg agagattctt acggtcgagg ctttgactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01001938             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4997:12571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001938
VERSION     KCXD01001938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4997:12571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..496
     V_segment       133..426
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60420.1"
                     /translation="CVRDRRVQSLSWFDAW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          102 a          124 c          154 g          118 t
ORIGIN      
        1 acatgggaga ggagcccagc cccagaattc ccaggtgttt ctgctcggcg atcagcacta
       61 aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc tcttttgaaa
      121 ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa gcctgggggg
      181 tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta catgagctgg
      241 gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc tggtggggat
      301 agcacatact atgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag
      361 aacacactgc atcttcaagt ggacagcctg agagctgagg acacggctgt ctatttctgt
      421 gtgagagatc gacgtgttca gtcgttatcc tggttcgatg cctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01001939             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:8513:4525
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001939
VERSION     KCXD01001939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:8513:4525"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60421.1"
                     /translation="CVRERFGGIGVIIFNWIDVW"
     D_segment       464..470
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          109 a          122 c          161 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcctga caaagcctgg
      181 ggggtccctg agactctcct gtgcagcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggggtgggtc tcacgaatcg gtcatgatgg
      301 tggtttcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagagtgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gacgacacag ccgtatatta
      421 ctgtgtgaga gagcggtttg ggggaattgg ggtaataatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01001940             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19874:17821
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001940
VERSION     KCXD01001940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19874:17821"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..495
     V_segment       115..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60422.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       415..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>501
                     /gene="IGHG"
BASE COUNT          109 a          136 c          147 g          109 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aagacttctg gatacacctt cagcatctct gccatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg ggtggatggg agggatcatc cctcttgttg gtgtgacaaa ctacgaacag
      301 aagttccagg gcagagtcac gattaccgcg gacacgtcca cgaatacagt cttcatggaa
      361 ctgagcagcc tgagatctga ggacacggcc gtctactatt gtgcgacagg ggtatattac
      421 caggatgaat acggttattt ttatgtcggc ggtgactttg actactgggg ccagggagtc
      481 ctggtcaccg tctccccagc c
//
LOCUS       KCXD01001941             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13339:5430
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001941
VERSION     KCXD01001941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13339:5430"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60423.1"
                     /translation="CARWEAADFDYW"
     D_segment       406..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           87 a          131 c          137 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggtggtta tggctggagt tggatccgcc aggccccagg gaagggactg
      241 gagtggattg ggactatgta tggtcatagt ggtagtaccc gctacaatcc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccact tttccctgac gctgagctct
      361 ctgaccgcct cggacacggc cgtgtattac tgtgcgagat gggaggcagc ggactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001942             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:4714:8390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001942
VERSION     KCXD01001942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:4714:8390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60424.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          124 a          138 c          135 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtaac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01001943             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5156:16127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001943
VERSION     KCXD01001943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5156:16127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60425.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       420..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          108 a          141 c          147 g          107 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 ctcaggtcca gctggtgcag tccggggctg agatggagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacagcttca gcatctatgt catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag gcatcttccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga ttaccgcgga cacggccaca agcacagcct
      361 acatggacct gagcagcctg ggatctgggg acacggccgt gtattattgt gcgagaggtt
      421 actgtactgg caatggttgt aaccttactt tcaaccggct cgatgtctgg ggcccgggag
      481 tcccggtcac cgtctcctca gcc
//
LOCUS       KCXD01001944             403 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:28046:17718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001944
VERSION     KCXD01001944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 403)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 403)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:28046:17718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    231..401
                     /note="immunoglobulin heavy chain variable region"
     V_region        231..401
     V_segment       231..340
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <332..>370
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60426.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       344..356
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       360..401
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        402..>403
                     /gene="IGHG"
BASE COUNT           91 a           97 c          116 g           99 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca actctgtgaa
      241 ggaccgattc accatctcca gagacaattc caagaacatg ctatatcttc aaatgaacaa
      301 cctgaaattg gaggacacgg ccctgtatta ctgtgcgaga ggggaataca gtaactctat
      361 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001945             379 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12753:6318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001945
VERSION     KCXD01001945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 379)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 379)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12753:6318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    23..377
                     /note="immunoglobulin heavy chain variable region"
     V_region        23..377
     V_segment       23..316
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <308..>346
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60427.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       329..335
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       336..377
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        378..>379
                     /gene="IGHG"
BASE COUNT           92 a           86 c          114 g           87 t
ORIGIN      
        1 acatgggaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
       61 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      121 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      181 tgatgcaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      241 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      301 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      361 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001946             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8480:15030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001946
VERSION     KCXD01001946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8480:15030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60428.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          141 c          145 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaaatgaa gaagcctggg gcctcagtta
      181 gggtctcctg caaggtttcc ggaaacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgtcga tcctgcacaa ggtgaaataa
      301 tatacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 ccttcatgga gttgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgaaag
      421 gggggttcgg aaccagcgtc tggtccaacc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01001947             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:25701:6382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001947
VERSION     KCXD01001947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:25701:6382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60429.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          141 c          152 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga gcttccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca gcgtctcctc agcc
//
LOCUS       KCXD01001948             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20060:15988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001948
VERSION     KCXD01001948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20060:15988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60430.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       268..279
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           80 a           72 c           94 g           76 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcagtt tcagtaatta
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gaatgggtgg cagttatgtc
      121 atctgatgga actaagaaat tctacgcaga ctctgtgaag gtccgattca ccatctccag
      181 agacaattcc aagaacatgg tatatcttca aatgaacagc ctgaaatcgg aggacacggc
      241 cgtatattat tgtgggagag atgataatgg ggtgattatc gactactggg gccagggagt
      301 cctggtcacc gtcacctcag cc
//
LOCUS       KCXD01001949             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7850:7511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001949
VERSION     KCXD01001949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7850:7511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60431.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          140 c          146 g          107 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata cagcttcagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggca atggttgtaa ccttactttc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01001950             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22050:6565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001950
VERSION     KCXD01001950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22050:6565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60432.1"
                     /translation="CATGRMGSSGWSNLFTGLESW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          143 c          146 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgtaaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tgggaaaggc cttgagtgga tgggagttgt tgatcctgtc aatggtgaag aaatacacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tcgacagaca cagcctacat
      361 ggacttgacc agtctcagat ctgaggacac ggccatctat tactgtgcga cagggaggat
      421 gggtagcagc ggctggtcca acctcttcac tggtttggaa tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001951             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6034:11518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001951
VERSION     KCXD01001951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6034:11518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60433.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           99 a          139 c          141 g           99 t
ORIGIN      
        1 acatggggat cacacaacag ccacttccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcgt cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gtatatggtg aaatggtgtt
      301 ccagggcggg gtcaccatga ccgaggacac gtctacagac acagcctact tggagctgaa
      361 cagcctgagg tctgaagaca cggccgtgta ttactgtgcg attggcccta gcggcatctg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01001952             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18851:12868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001952
VERSION     KCXD01001952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18851:12868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..503
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60434.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       425..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>507
                     /gene="IGHG"
BASE COUNT          118 a          143 c          142 g          104 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg attcaccttc agcaccgatg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga ctggatggga ggggtcatcc ctcttatggg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg tttaccgcgg acacgtccct aaccacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattattg tgcgaaatcc
      421 gtgaattacg aggaagataa cggttactat ataccgacgc agtttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctctgcc
//
LOCUS       KCXD01001953             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26345:13221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001953
VERSION     KCXD01001953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26345:13221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60435.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          126 c          161 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgccg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agcctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag ggattaacag
      301 tggtggggat actacatacc acgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccaag aacacactgt ctcttcaaat ggacggcctg agagctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatct tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01001954             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:25034:3884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001954
VERSION     KCXD01001954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:25034:3884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60436.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          133 c          138 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtgg acacgtccga gaaccagtgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggtc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001955             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23751:3630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001955
VERSION     KCXD01001955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23751:3630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    97..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        97..451
     V_segment       97..390
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60437.1"
                     /translation="SARDVFGGGLDYW"
     D_segment       393..397
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           99 a          103 c          139 g          112 t
ORIGIN      
        1 acatgggcgg tgatcagcac agaacacaga ggactcacca tgaagtttgg gctgagctgg
       61 gttttccttg ttgctatttt aagaggtgtc cagtgtgacg tgcagctggt ggagtctgga
      121 ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgcagcttc tggattcacc
      181 ttcagtaact ttggcatgca ctgggtccgc caggctccag ggaaggggct ggactgggtg
      241 gcagttatgt cgtctgatgg aagtaagaaa tactacgcag actctgtgaa ggaccgattc
      301 accatctcca gagacaattc caagaacatg gtatatcttc aaatgaacac cctgaaattg
      361 gaggacacgg ccgtgtatta ttctgcgaga gatgtctttg gcgggggact tgactactgg
      421 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001956             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19532:5145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001956
VERSION     KCXD01001956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19532:5145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60438.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          124 c          147 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attccccttc actacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctcga gtggctgaca gttatatcgt
      301 ttgatgaaac taaggaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggcc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001957             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8130:10830
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001957
VERSION     KCXD01001957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8130:10830"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60439.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattattg tgcgagagga gactacggta acagccttga cttctggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01001958             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14196:11471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001958
VERSION     KCXD01001958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14196:11471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..511
     V_segment       139..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <424..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60440.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       454..461
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          110 a          132 c          158 g          113 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatg
      121 ttcagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggagactt ggtccagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctatggcatg
      241 acctgggtcc gccaggctcc agggaagggg ctggagtggg tctcatacat tagtattggt
      301 ggtagtaata gatactacgc agactccgtg aagggccgat tcaccatctc cagagacaac
      361 tcagagaaaa cgctctccct gcaaatgaac agcctgagac ctgaggacac ggccgtgtat
      421 tactgtgcgt cgaacctacg tggaaacacc tacacttact ggcggtcctt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001959             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14806:19810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001959
VERSION     KCXD01001959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14806:19810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60441.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          109 a          122 c          153 g          125 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcctg gcaaagcccg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gaacaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtactagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001960             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10957:9977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001960
VERSION     KCXD01001960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10957:9977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60442.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          113 c          154 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 aatgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct atttcttcaa atggacaacc tgaaattgga ggacacggcc
      421 gtctattatt gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001961             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22485:8830
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001961
VERSION     KCXD01001961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22485:8830"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60443.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          115 c          150 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 accggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 cttgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tttctagaga
      361 caattccatg aacatgctat ttcttcaaat gaacaacctg aacttggacg acacggccgt
      421 ctattactgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001962             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15768:9353
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001962
VERSION     KCXD01001962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15768:9353"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60444.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          121 a          142 c          133 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgacag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatctt
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccccggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01001963             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13123:18031
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001963
VERSION     KCXD01001963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13123:18031"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..374
     V_segment       20..313
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60445.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       314..319
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       332..374
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           87 a           89 c          108 g           92 t
ORIGIN      
        1 acatgggggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
       61 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actttggcat
      121 acactgggtc cgccaggctc ccgggaaggg tctggagtgg gtagcagtta tctcccatga
      181 tgaaaataat atatattacg cagactccgt gaaggaccga ttcaccatct ccagagacaa
      241 ttccaagaac aacgtatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgtt
      301 ttactgtgtg agagatacat tcggttcagg atttgactac tggggccagg gagtcctggt
      361 caccgtctcc tcagcc
//
LOCUS       KCXD01001964             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:12980:12696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001964
VERSION     KCXD01001964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:12980:12696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60446.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           92 a          131 c          137 g           99 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgag gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcga tgtctctggg
      181 ggctccatca gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtgtatcta cgatagtagt ggaaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gatgaggtct
      361 atgaccgccg cggacgcggc cgtgtattat tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001965             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11259:16726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001965
VERSION     KCXD01001965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11259:16726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60447.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          155 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaac taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tatattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01001966             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21560:11958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001966
VERSION     KCXD01001966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21560:11958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60448.1"
                     /translation="CARERCSASSCAGFLDSW"
     D_segment       413..420
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          107 a          138 c          143 g           97 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtaca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa gtttcctgca
      181 aggcttctgg attcaccctc gacaactatg gcatcaactg ggtgcgccag gcccccggac
      241 aggggcttga gtggatggga gtgatcatcc cccttattgg aataataaac tacgcagaga
      301 acgtccaggg cagagtcgcg atttccgcgg acacgtccat aaatacagcc tacatggagg
      361 tgcgcagcct gagatctgag gacacggcca tctattactg tgcgcgagaa cgttgtagtg
      421 ctagcagttg cgccggattc ctagactcct ggggccaggg agccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01001967             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:2723:12155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001967
VERSION     KCXD01001967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:2723:12155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60449.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       438..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          113 c          154 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag tagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatatctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatatcgtc
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcaaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01001968             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21881:15615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001968
VERSION     KCXD01001968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21881:15615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60450.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          112 c          150 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagcacc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatttt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacgggat ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001969             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17137:15783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001969
VERSION     KCXD01001969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17137:15783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60451.1"
                     /translation="CARDAGVGATILYYYDFW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          135 c          137 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcag tgtctctggt
      181 ggctccttca gtggttacta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ttatcggcgg tggtagtggg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtccaag aatcaattct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt ttattactgt gcgagagatg cgggagtggg agccacaatc
      421 ctttattact atgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01001970             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:11806:5973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001970
VERSION     KCXD01001970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:11806:5973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60452.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          110 a          141 c          133 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag ttttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggtaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgcgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01001971             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:21163:11860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001971
VERSION     KCXD01001971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:21163:11860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60453.1"
                     /translation="CARAVGGAAGYFDFW"
     D_segment       439..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          106 a          126 c          154 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccat tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 acatgaactg ggtccgccag actccaggca aggggctgga atggatctca ggtattaaca
      301 ctggtggcat taacacatac tatgcggact ccgtgaaggg cagattcacc atctccagag
      361 aggacgccaa gaacacactg tttcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcgagagca gtgggtggtg ccgcaggata cttcgatttc tggggcctgg
      481 gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01001972             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20245:10698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001972
VERSION     KCXD01001972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20245:10698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60454.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcattcactg ggtccgccag actccgggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagacatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggtg tattttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgcgagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001973             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19106:7996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001973
VERSION     KCXD01001973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19106:7996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60455.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          112 c          155 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcagctt cagtggcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata ttacgcagac tctgtgaagg accgattcac cgtctccaga
      361 gacaattcca agaacatgct atattttcaa atgaacaacc tgaaattgga agacacggcc
      421 gtatattact gtgcgagaga tgtctatggc aggggacttg acttctgggg cctgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01001974             369 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20056:11669
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001974
VERSION     KCXD01001974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 369)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 369)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20056:11669"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..367
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..367
     V_segment       7..279
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>336
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60456.1"
                     /translation="CARVLYYDSGYSTNPYNRFDVW"
     D_segment       286..304
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       317..367
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        368..>369
                     /gene="IGHG"
BASE COUNT           83 a           95 c          110 g           81 t
ORIGIN      
        1 acatgggggg ctgaggtgaa gaagcctggg gcctcagtga agctctcctg caaggcttct
       61 ggatacacct tcagcatcta tgccatcagt tgggtgcgac aggcccctgg acaagggctt
      121 gagtggatgg gagggatcat ccctcttgtt ggtttaacaa acgacgcaca gaagttccag
      181 ggcagagtca ccattaccgc ggacacgtcc acaagcacag cctacatgga gctgagcagc
      241 ctgagatctg aggacacggc cgtgtattac tgtgcgagag ttttatacta tgatagtggt
      301 tattccacga acccgtacaa ccggttcgat gtctggggtc cgggagtcct ggtcaccgtc
      361 tcgtcagcc
//
LOCUS       KCXD01001975             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17689:2480
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001975
VERSION     KCXD01001975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17689:2480"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60457.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          116 c          147 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acacagactc tgtgaagagc cgattcacca tctccagaga
      361 caattcccag aacatacttt atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001976             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19560:17390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001976
VERSION     KCXD01001976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19560:17390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60458.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          114 a          143 c          128 g           92 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttccggata caccttaacc gaccactacc tacactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt attcttcctg agtatggtaa agttgactac
      301 acacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga gacagtctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01001977             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15986:5174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001977
VERSION     KCXD01001977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15986:5174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60459.1"
                     /translation="CARVSGIAESSVEYFEFW"
     D_segment       438..447
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..507
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          117 a          120 c          152 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtggc tatggcatgc
      241 actgggtccg ccagtctcca ggggaggggc tggaatgggt ggcacttata tcgtatgatg
      301 gaactaagaa atactacgca gactctatga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agtaagcggt atagctgaaa gttccgttga atacttcgag ttctggggcc
      481 agggcgccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001978             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13123:16788
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001978
VERSION     KCXD01001978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13123:16788"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    132..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        132..486
     V_segment       132..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60460.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       434..445
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          113 a          107 c          150 g          118 t
ORIGIN      
        1 acatgggggg agcccagccc tggaagtcca cagtgttcca ttcggtgatc agcacagaac
       61 acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct attttaagag
      121 gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag ccgggggggt
      181 ccctgagact ctcctgtgca gcctctggat tcagtttcag taattatggc atgcactggg
      241 tccgccaggc tccagggaag gggctggaat gggtggcagt tatgtcatct gatggaacta
      301 agaaattcta cgcagactct gtgaaggtcc gattcaccat ctccagagac aattccaaga
      361 acatggtata tcttcaaatg aacagcctga aatcggagga cacggccgta tattattgtg
      421 ggagagatga taatggggtg attatcgact actggggcca gggagtcctg gtcaccgtca
      481 cctcagcc
//
LOCUS       KCXD01001979             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18214:8098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001979
VERSION     KCXD01001979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18214:8098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60461.1"
                     /translation="CAREGISASGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          134 c          146 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacgtact acaacccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaaa gagcagttct ccctgaggct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc gtcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01001980             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12979:12919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001980
VERSION     KCXD01001980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12979:12919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60462.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       446..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          115 c          156 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cggcctctgg attcaccttc agaacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatgaaac taacaaatac tacggagact ctgtgaaggg ccgattcagc atctccagag
      361 acaattcgaa gaacatgcta tatcttcaaa taaacaccct gaaattggag gacacggccg
      421 tgtattactg tgcgacagat gcgtttggta gtgggattga ccactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001981             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18612:8024
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001981
VERSION     KCXD01001981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18612:8024"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..503
     V_segment       137..422
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60463.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       438..445
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          119 c          143 g          128 t
ORIGIN      
        1 acatggggga gaggagccca gccctgggat tcccaggtgt tttcattcag agatcaggac
       61 tgaacacaca ggactcacca tggagtttat gctgagctgg gttttccttg tttctatatt
      121 aaaaggtgtc cagtgtgtgg agcatctggt ggagtctggg ggaggcttgg tacagcctgg
      181 ggcgtccctg agactctcct gtgcagcctc tgaattcacc tttagtggct atgacatgca
      241 ctgggttcgc caggctccag ggaagggtct agaatgggta tcaggtatta acattggcgg
      301 tgacccatac tacccagact ctgtgaaggg tcgattcacc atctccagag acaacgccaa
      361 gaactccttg tatcttcaaa tgaacaacct gagacctgag gacactgctg tgtattattg
      421 tgtgaggggg atggataact accacttcag taatacggac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001982             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19362:5126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001982
VERSION     KCXD01001982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19362:5126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60464.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          120 a          142 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctgttgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggg agtgttgatc ctcaatatgg tgagatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgac gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcat cc
//
LOCUS       KCXD01001983             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23898:18524
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001983
VERSION     KCXD01001983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23898:18524"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60465.1"
                     /translation="CARTTSRGLVFDFW"
     D_segment       400..404
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           92 a          139 c          128 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcagttact ggtggaactg gatccgccag cccccaggga agggactgga
      241 gtggcttggg gagatcaatg gtaatagcgg aaccaccaac tacaatccct ccctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaatcagttc tccctgaacc taaattctgt
      361 gaccgccgcg gacacggccg tctatttctg tgcgaggacc acctcccggg gacttgtttt
      421 tgatttctgg ggccaagggc tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01001984             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19499:17579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001984
VERSION     KCXD01001984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19499:17579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60466.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          121 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaatatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01001985             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21057:14078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001985
VERSION     KCXD01001985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21057:14078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60467.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       431..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          129 c          146 g          105 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gatgcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacagcg tcaccgaatt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgtaaaa ggtgaaataa
      301 ttcacggaga ggggttccag gacagagtca ccatgaccga ggacccgtct acagacacag
      361 cctacatgga gttgagcaac ctgagatcag aggacacggc cgtttattat tgtgcgagtg
      421 ggtttagtat ctggttattt tacgacgttc tggattcgtg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001986             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22194:8451
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001986
VERSION     KCXD01001986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22194:8451"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60468.1"
                     /translation="CARDVRGTGFDFW"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          112 c          152 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt tcagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttccgcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccatatatt
      421 actgtgcgag agatgtcagg ggcacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001987             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22240:19311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001987
VERSION     KCXD01001987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22240:19311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..456
     V_segment       78..371
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60469.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       392..398
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..456
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           91 a          120 c          142 g          105 t
ORIGIN      
        1 acatggggcc agttccactg ggtccagtga agtggtgtct cattcactcc tctgtcctct
       61 ccacaggcgc cctctctgag gtccaactgg tgcagtctgg ggctgaggtg aggaagcctg
      121 gggcctcagt gaaggtctcc tgcaaggttt ccggagacac cttcagcgaa ttatccatgc
      181 actgggtgcg acaggcccct ggaaaagggc ttgagtggtt gggaggtgtt gatcctgcaa
      241 atggtgaggt aatacacgca gatagttttc agggcagagt caccatgacc gaggacacgt
      301 ctacactcac agcctacatg gagctgagcg gcctgagatc tgaggacacg gccgtgtatt
      361 actgtgcgag agggcaattc ggtaccagcg tctggtccaa tctcgtctat ggtttggatt
      421 cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01001988             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18959:5989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001988
VERSION     KCXD01001988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18959:5989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60470.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          119 a          145 c          132 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacatc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgaatt atcattgcac tgggtgcgcc
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga ccctgcatat ggtgaaatga
      301 tacacacaga gatattccag ggcagaatca ccatgaccga ggacacgtca acagacacag
      361 cctacatgga gctaagcagc ctgagatctg aggacacggc cgtttattac tgtgcgatat
      421 catccagcgg cacctggcta ttctggtact tcgatgtctg gggccctggc tccccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01001989             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:9208:9654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001989
VERSION     KCXD01001989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:9208:9654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60471.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          139 c          136 g           94 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa agtccaaggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcgt
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcgtcagc c
//
LOCUS       KCXD01001990             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4534:8499
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001990
VERSION     KCXD01001990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4534:8499"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60472.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       417..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          112 a          143 c          137 g           91 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tctttctggt gcagtctggg gctgaggtga agcagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ctcaccgaag tgtccactca ctgggtgcga
      241 caggcccccg gaaaagggct tgagtgggtg ggaagtgttg atcctgcata tggtgaaatg
      301 aagttccagg gcagagtcac catgaccgag gacacgtcca cagacacagc ctacatgaaa
      361 ttgagcagcc taagatctga ggacacggcc gtgtattact gtgcgattgg acctaccggc
      421 aggtggaacg gctggtcctt cgatatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01001991             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23220:15336
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001991
VERSION     KCXD01001991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23220:15336"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60473.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtgg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaacttggag gacacggccg
      421 tctatcactg tgcgagggac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01001992             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7824:6765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001992
VERSION     KCXD01001992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7824:6765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..343
     V_segment       8..267
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <259..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60474.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       293..297
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..343
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           75 a           87 c          106 g           77 t
ORIGIN      
        1 acatgggaga agcctggggc ctcagtgaag gtctcctgca aggttttcgg atacaccttc
       61 agcgatttat ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtggatggga
      121 ggtgttgaca ctgtctctga cggagtgata tacgcagaga acttccaggg cagagtcgcc
      181 atgaccgagg acacgtctac agacacagcc tacatggaat tgagcagcct gagatctgag
      241 gacacggccg tttattactg tgcgagaggt ttatcaccag acgtcttcgg tttcctcggg
      301 cttggctact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01001993             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4685:13636
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001993
VERSION     KCXD01001993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4685:13636"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..474
     V_segment       123..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60475.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       406..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..474
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          114 a          135 c          135 g           92 t
ORIGIN      
        1 catgggggca tcacacaaca accacatccc tcccctacag aagccccaga gcagagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctgatgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggttaccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa aggacttgag tggatgggaa gtgttgatcc tgtatatggt gaaatgaaag
      301 agggcagagt caccatgacc gaggacacgt ctacagacac agcctacatg gaactgagta
      361 gcctgagatc tgaggatacg gccgtgtatt attgtgcagt cggcaatagc ggcagctgga
      421 tctcctggtc cttcgatgtc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01001994             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12207:13773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001994
VERSION     KCXD01001994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12207:13773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..441
     V_segment       78..371
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60476.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       381..387
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..441
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           94 a          103 c          138 g          108 t
ORIGIN      
        1 acatgggcac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
       61 tgaaaggtgt ccagtgtgag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg
      121 gggggtccct gagactctcc tgcgcagcct ctggattcag gttcaattat tactacatga
      181 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt agtagtggtg
      241 gggaaagcac atactctgca gactccgtga agggcagatt caccatctcc agagagaacg
      301 ccaagaacac actatatctt caaatggaca gcctgagaac tgaggacacg gctgtctatt
      361 tctgtgtgag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      421 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001995             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:9722:14254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001995
VERSION     KCXD01001995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:9722:14254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60477.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          110 c          152 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaactaagaa atactatgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatttctt caaatggaca acctgaaatt ggaggacacg gccgtctatt
      421 attgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001996             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19615:9009
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001996
VERSION     KCXD01001996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19615:9009"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60478.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          116 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt tgcagttaca tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccatgaacat ggtatatctt caaatgaaca acctgaagtt ggaggacacg gccgtctatt
      421 actgtgcgag agacgcatat ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01001997             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10507:18997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001997
VERSION     KCXD01001997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10507:18997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60479.1"
                     /translation="CARGVDNHHYSNTEFDLW"
     D_segment       454..461
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          121 c          151 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag caggtggtgg agtctggggg aggcttggta
      181 cagccggggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtggatatc aggtattaac
      301 attggcggtg acgcatacta cccagactct gcgaagggtc ggttcaccat ctccagagac
      361 aatgccaaga attccttgta tcttcaaatg aacagcctga gaactgagga cactgctgtg
      421 tattattgtg caagaggcgt agataaccac cactacagta atacggagtt tgacctctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01001998             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18709:9349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001998
VERSION     KCXD01001998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18709:9349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60480.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       269..274
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           76 a           72 c           96 g           78 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcatgt tcagtaacta
       61 tggcatccac tgggtccgcc aggctccagg gaaggggctg gagtgggtgt cagttatatc
      121 gtatgatgta actgtgaaat actacgcaga ctctgtgaag gaccgattca ccatctccag
      181 agacaattcc aagaatacgg tatatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtgtattat tgtgtgagag atgtcagggg aacggggttt gacttctggg gccagggagt
      301 cctggtcacc gtctcgtcag cc
//
LOCUS       KCXD01001999             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:25684:6960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01001999
VERSION     KCXD01001999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:25684:6960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60481.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       432..447
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          105 a          123 c          158 g          115 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagcactgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaggtg gtggagtctg ggggcggctt ggcaaagcct
      181 gggggatccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctatgcaatg
      241 cactgggtcc gccaggctcc agggaagggg ctggaatggg tctcagccat tagtgttggt
      301 ggtagtacat attacgcagg ctccgtgagg ggccgattca ccatctccag agacaactca
      361 gagaacacgc tctccctgca aatgaacagc ctgagacctg aggacacggc cgtgtattac
      421 tgtgcgaaag gggatacagc tacagtttat tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01002000             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19787:15779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002000
VERSION     KCXD01002000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19787:15779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60482.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          138 c          130 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggcgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccgtcacc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaggagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002001             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17378:16885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002001
VERSION     KCXD01002001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17378:16885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60483.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          102 a          124 c          155 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacaaacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagtttct actacatgag
      241 ctgggtccgc cagcctccag ggaagggtct ggagtggatc tcaggtatta acgctggtgg
      301 ggatggcaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagaact gaggacacgg ctgtctattt
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002002             335 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20023:11583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002002
VERSION     KCXD01002002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 335)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 335)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20023:11583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..333
     V_segment       4..266
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>302
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60484.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       276..282
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>335
                     /gene="IGHG"
BASE COUNT           61 a          101 c           99 g           74 t
ORIGIN      
        1 acatggggaa gccttcggag accctgtccc tcacctgcgc tgtctctggt ggctccttca
       61 gcggttacta ctggggctgg atccgccggc ccccagggga gggtctggag tggattgggt
      121 atatcagtgg gagtggtggg agttccgact acaagtcctc cctcaagagt cgagtcacca
      181 tttcaacaga cacgtccaag aaccacttct ccctgaagct gacctctgtg accgccgcgg
      241 acacggccgt gtattactgt gcgagagtcc ggggcgtaac tatccactac tttgactact
      301 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002003             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15332:16906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002003
VERSION     KCXD01002003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15332:16906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..496
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60485.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>499
                     /gene="IGHG"
BASE COUNT          116 a          114 c          146 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtaca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaaattttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acgccaactc tgtgaagagc cgattcacca tttccagaga
      361 caattccaag agcatactat atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01002004             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16384:6065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002004
VERSION     KCXD01002004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16384:6065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60486.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       397..404
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           93 a          136 c          127 g          109 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcggct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagca gtagctactg gaactgggtc cgccagcccc cagggaaggg actggaatgg
      241 attgggtata tctctggtgc ttatgggagc accaactaca acccctctct caagagtcga
      301 gtcaccattt cactagacac gtccaagagc cacttttccc tgaggctgag ttctgtgacc
      361 gccgcggaca ccgccgtata ttactgtgtg agatatgagg atgaatccat taattaccac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002005             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14881:9456
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002005
VERSION     KCXD01002005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14881:9456"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60487.1"
                     /translation="CARDRDTRSGYYGLDSW"
     D_segment       451..459
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..510
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          120 c          157 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg actcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat agggatacac gcagcggcta ttacggtttg gattcctggg
      481 gccgaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002006             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18800:7053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002006
VERSION     KCXD01002006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18800:7053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60488.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       440..452
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          115 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatttttag aggtgtccag tgtgaagtcc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgcga ctctcctgtg cagcctctgg attcaccttc actacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaag taagaaatat tacgcagact ctgtgaagga ccgattcacc ttgtccagag
      361 acaataccaa gaacatgcta tatattcaaa tgaacaacct gaaattggag gacacggcca
      421 tgtattactg tgtgagagat gactacggta gcggcctcgg gtcctggggc cagggagtcc
      481 tggtgaccgt ctcctcagcc
//
LOCUS       KCXD01002007             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13818:15049
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002007
VERSION     KCXD01002007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13818:15049"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60489.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       262..267
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           76 a           75 c           92 g           76 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtggctttgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      121 tgatgaaact aagaaatatt acgcagactc tgtgaaggac cgattcaccg tctccagaga
      181 caattccaag aacatgctat attttcaaat gaacaacctg aaattggaag acacggccgt
      241 gtattactgt gcgagagatg tctatggcag gggacttgac tactggggcc tgggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002008             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7916:10737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002008
VERSION     KCXD01002008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7916:10737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60490.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       412..421
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           95 a          144 c          135 g           99 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggc
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag tcctcagaga ccctgtccct cacctgcgct gtctctggtg
      181 cctccatcgg tagttactgg tggacctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatgga aatagcggta gtacctacta cagcccctcc ctcaagagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga accaccactc cctgaagctg aactctgtga
      361 ccaccgcgga cacggccgtg tatttctgtg cgaacgtctt aggcccctgg ggcagctggt
      421 cacactactt tgagtactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002009             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20755:16853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002009
VERSION     KCXD01002009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20755:16853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60491.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       422..429
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          138 c          151 g           98 t
ORIGIN      
        1 atggggatca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccaact ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggagac accttcaccg aattatccat gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaggtg ttgaccctgc aaatggtgaa ataatacacg
      301 cagatagttt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cggcctgaga tctgaggaca cggccgtgta ttactgtgcg agaggggggt
      421 tcggtagcag tgtctggtcc aatctcgtct atggtttgga ttcctggggc caaggggtcg
      481 ccgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002010             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:25556:10249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002010
VERSION     KCXD01002010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:25556:10249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60492.1"
                     /translation="CVKGETAAAYYGLDSW"
     D_segment       440..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          124 c          157 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttatgc
      241 tatgaattgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ctgttagtac
      301 tagtggaagt acatactacg cagactccgt taagggccgg tgcaccatct ccagagacaa
      361 ctcaaagaac atgctctccc tgcaaatgaa cagcctgagc gctgaggaca cggccgtgta
      421 ttactgtgtg aaaggagaaa cagctgcagc atactacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002011             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22605:15631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002011
VERSION     KCXD01002011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22605:15631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60493.1"
                     /translation="CARWGDSQSIYYFDYW"
     D_segment       398..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>469
                     /gene="IGHG"
BASE COUNT           91 a          133 c          135 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctattagc agtagtaact ggtggaactg gatccgccag cccccaggga aagggctgga
      241 gtggattggg tatatcagtg gtgctagtgg tagtaccgac tatcacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt accctgaagt tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg ggtgactccc agtccattta
      421 ctactttgac tactggggcc agggagtcct ggtctccgtc tccttagcc
//
LOCUS       KCXD01002012             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16444:13828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002012
VERSION     KCXD01002012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16444:13828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60494.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          116 c          151 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccatgaacat ggtatatctt caaatgaaca acctgaagtt ggaggacacg gccgtctatt
      421 actgtgcgag agacgcatat ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002013             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:7092:5200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002013
VERSION     KCXD01002013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:7092:5200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60495.1"
                     /translation="CARDGYSRSESFYGLDSW"
     D_segment       403..409
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          139 c          139 g          101 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctttgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtaact attggagttg gatccgccag gccccaggga ggagactgga
      241 gtggattgga cgtatctctg ggagtggagg gagcaccgac tacaacccct ccctccagag
      301 tcgagtcacc atttcaacag acacgtccac gaaccagcac tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagac ggctatagta gaagcgaaag
      421 tttctacggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002014             413 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:24198:4839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002014
VERSION     KCXD01002014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 413)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 413)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:24198:4839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    57..409
                     /note="immunoglobulin heavy chain variable region"
     V_region        57..409
     V_segment       57..350
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <342..>380
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60496.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       353..361
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       372..409
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        410..>413
                     /gene="IGHG"
BASE COUNT           91 a           88 c          133 g          101 t
ORIGIN      
        1 acatgggggg gctgagctgg gttttccttg ttgctatttt aagaggtgtc cagtgtgagg
       61 tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg ggggtccctg agactctcct
      121 gtgcagcctc tggattcacc ttcagttact atggcatgca ctgggtccgc caggctccag
      181 ggaaggggct ggagtgggtg gcagttatgt cgaatgatgg aagtaagaaa tactacggag
      241 actctgtgaa ggaccgattc accatctcca gagacaattc caagaatagg ctatatcttc
      301 aaatgaacaa cctgaaattg gaggacacgg cagtgtatta ctgtgcgaga gatgatagtg
      361 gggtgatcat cgactactgg ggccagggag tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01002015             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13413:2197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002015
VERSION     KCXD01002015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13413:2197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60497.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          140 c          145 g          107 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata cagcttcagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggca atggttgtaa ccttactttc aaccggctcg atgtctgggg cccgagagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01002016             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4450:21087
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002016
VERSION     KCXD01002016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4450:21087"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..469
     V_segment       115..394
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60498.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       402..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          102 a          136 c          138 g           95 t
ORIGIN      
        1 acatggggaa caaccacatc cctcccctac agaagcccca gagcacagca cctcaccatg
       61 gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca ctctgaggtc
      121 cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa ggtctcctgc
      181 aaggtttccg gatacacctt caccgaattg tccatgcact gggtgcgaca ggcccctgga
      241 aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatggt gttccagggc
      301 agagtcacca tgaccgagga cacgtctata gacacagcct acatggagtt gagcagcctg
      361 agatctgagg acacggccgt gtattactgc gcgattggcc ctagcggcaa ctggaacggc
      421 tggtccttcg atatctgggg acctggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01002017             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12516:15714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002017
VERSION     KCXD01002017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12516:15714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60499.1"
                     /translation="CGRDDSGVIIDYW"
     D_segment       445..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          116 c          154 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtacctatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgcgaagga ccgatttacc atctccagag
      361 acaatcccaa gaacctgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gattctgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002018             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13991:6269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002018
VERSION     KCXD01002018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13991:6269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..394
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60500.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       400..407
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..464
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          101 a          112 c          141 g          112 t
ORIGIN      
        1 acatggggag agattgagtg ggagtggaca tgaatgagag gaacagtgga tatgtgtgac
       61 agtttctgac cttggtgtct ctctctttgc aggtgtccag tgtgaggtgc aggtggagga
      121 gtctgggggc ggcttggcaa agcctggggg atccctgaga ctctcctgtg cagcctctgg
      181 attcaccttc agtacctatg ctatgcattg ggtccgccag gctccaggga aggggctgaa
      241 atgggtctca tctattagta gtggtggtct cacatactac gcagactccg tgaagggccg
      301 atttgccatc tccagagaca actcaaagaa cacgctctcc ctgcaaatga acagcctgag
      361 cgctgaggac acggccgtat attactgtgc gaaaggaggt agcagctctt tctattggta
      421 cttcgatatc tggggccctg gcaccccagt gaccatctcc tcagcc
//
LOCUS       KCXD01002019             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20257:17741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002019
VERSION     KCXD01002019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20257:17741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60501.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          116 c          151 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtggctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtgcagtct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaactt ggaggacacg gccgtctatt
      421 actgtgcgag ggacgcattt ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002020             415 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9581:17011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002020
VERSION     KCXD01002020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 415)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 415)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9581:17011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    32..413
                     /note="immunoglobulin heavy chain variable region"
     V_region        32..413
     V_segment       32..324
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <317..>382
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60502.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       334..357
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       380..413
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        414..>415
                     /gene="IGHG"
BASE COUNT           93 a          110 c          126 g           86 t
ORIGIN      
        1 acatggggca gcagctacag gtgcccagtc ccaggtccag ttggtgcagt ccggggctga
       61 ggtgaagagg cctggggcct cagtgaagct ctcctgcaag gctcctggat acatcttcag
      121 tatatctgcc atcagttggg tgcgacaggc ccctggacaa gggcttgagt ggatgggagg
      181 gatcatccct cttgttggtg taacaaccaa cgcacagaag ttccaggaca gagtcacgat
      241 taccgcggac acgtccacaa gcacagccta catggagctg agcagcctga gatctgagga
      301 cacggccgtg tatttctgtg cgagtggcgg cttcgaggat gataacggtc actattatac
      361 gacactaaca tttcacgatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002021             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12794:24122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002021
VERSION     KCXD01002021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12794:24122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60503.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          113 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatatctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtgtca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002022             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:3629:8404
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002022
VERSION     KCXD01002022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:3629:8404"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..478
     V_segment       115..408
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60504.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       418..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..478
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          105 a          113 c          144 g          118 t
ORIGIN      
        1 acatggggat tcccaggtgt ttctgttcgg cgatcagcac aaaacacaga acataccatg
       61 gagtttgtgc tgagctgggt tttccttgtt gctcttttga aaggtgtcca gtgtgaggtg
      121 aagctggtgg agtctggggg cggcttggca aagcctgggg ggtccctgag actctcctgc
      181 gcagcctctg gattcagctt caattattac tacatgagct gggtccgcca ggctccaggg
      241 aaggggctgg agtggatctc aggtattaat catggtgggg aaagtacata ctatgcagac
      301 tccgtgaagg gcagattcac cctctccaga gagaacgcca agaacacact atatcttcaa
      361 atggacagcc tgagaactga ggacacggct gtctattact gtgtgagaga tcgacgtgta
      421 cagtcgttat cctggttcga tgtctggggc ccgggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002023             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13009:14169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002023
VERSION     KCXD01002023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13009:14169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60505.1"
                     /translation="CARGIDNYHYTDTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          114 a          118 c          152 g          130 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 tgctatgtta aaaggtgtcc agtgtgtgga gcagctggtg gaatctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct ggattcacct tcagtagctt
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtctg gactgggtat caggtattaa
      301 cattggcggt gacacatact acccagactc tgtgaagggt cgattcacta tgtccagaga
      361 caatgccaag aactccgtgt atcttcaaat gaacagcctg agagttgagg acactgctgt
      421 gtatttttgt gcaaggggga tagataacta ccactatact gatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002024             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22949:10490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002024
VERSION     KCXD01002024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22949:10490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60506.1"
                     /translation="CARVDCSGGVCFFDYW"
     D_segment       444..462
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          112 a          113 c          157 g          127 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtggg atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
      241 gcatgaactg ggtccgccag gctccaggga aggggctgga gtggatggca attatttcgt
      301 atgatggaac taagaaatac tacgcagact ctgtgaagga ccggttcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacagcct gaaattggaa gacacggccg
      421 tgtattactg tgcgagagtg gactgtagtg gtggtgtctg cttttttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002025             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17140:8628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002025
VERSION     KCXD01002025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17140:8628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60507.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          109 a          124 c          153 g          129 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag ggtgaggtgc atctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgagc ggggcctgga gtggatctca gctattgata
      301 gtgctgttac tagtaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002026             401 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22310:9666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002026
VERSION     KCXD01002026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 401)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 401)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22310:9666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    45..399
                     /note="immunoglobulin heavy chain variable region"
     V_region        45..399
     V_segment       45..338
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <330..>368
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60508.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       348..353
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       357..399
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        400..>401
                     /gene="IGHG"
BASE COUNT           88 a           91 c          122 g          100 t
ORIGIN      
        1 acatgggggt tttccttgtt gctactttaa gagatgtcca gtgtgaggtg cagctggtgg
       61 agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt gcagcctctg
      121 gattcacctt cagtagcttt ggcattcact gggtccgcca ggctccaggg aaggggctgg
      181 agtgggtggc agttatatcg tatgatgaaa ctaagaaata ctacgcagac tctgtgaagg
      241 accgattcac cctctccaga gacaattcca agaacatgct atatcttcaa ttgaacaacc
      301 tgaaattgga ggacacggcc gtgtattact gtgcgagaga tgtcagggga acggggtttg
      361 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002027             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11890:11383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002027
VERSION     KCXD01002027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11890:11383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..466
     V_segment       112..408
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60509.1"
                     /translation="CARWSAANFDYW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          132 c          140 g          100 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcacggacc tcctgggcaa gaacatgagg
       61 catctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa
      121 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgat
      181 gtctctgggg gctccatcag cagtggttat ggctggagct ggatccgcca gcccccaggg
      241 aaggggctgg agtggattgg gtgtatctac gatagtagtg gaaacaccta ctacaacccc
      301 tccctcaaga gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaag
      361 atgaggtcta tgaccgccgc ggacgcggcc gtgtattatt gtgcgagatg gtcggcagcc
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002028             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:9876:7393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002028
VERSION     KCXD01002028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:9876:7393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60510.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          111 c          156 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtact tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaataa atactacgca gactctgtga aggcccgatt caccgtctcc agagacaatt
      361 ccaagaacat gttatatctt caaatggaca acctgaaatt ggaagacacg gccgtgtatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002029             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17629:14313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002029
VERSION     KCXD01002029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17629:14313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60511.1"
                     /translation="CASPLLPAAGNW"
     D_segment       408..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           78 a          140 c          129 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcgctg tctctggtta
      181 ctccgtcaac agtggttatt cttggggctg gctccgtcag cccccaggga agggactgga
      241 gtggattgga tttatcggtg gtcgtagtgg gttcacccac tacaatccct ccctgaagag
      301 tcgagtctcc atttcaaccg acacgtccaa taaccagttc tccctgcaac tgatctctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagtcct ctccttccgg cagctggaaa
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002030             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14250:14043
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002030
VERSION     KCXD01002030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14250:14043"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..438
     V_segment       75..368
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60512.1"
                     /translation="CARYELFGNQYNFDYW"
     D_segment       373..379
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           92 a          130 c          119 g           99 t
ORIGIN      
        1 acatggggtg caagaacatg aagcacctgt ggttcttcct tctcctggtg gcagctccca
       61 gatgggtcct gtcccaggtg cagctgcagg agtcgggccc aggactggtg aagcctgcgg
      121 agaccctgtc cctcacctgc gctgtctctg gtggctccat caacaataac tactggacct
      181 ggatccgcca gcccccaggg aagggactgg aatggattgg atatatctat ggtggttctg
      241 ggagcaccac ctacaacccc tccctcaaga gtcgagtcac catttcaaca gacacgtcca
      301 ggaacctgtt ttccctgaac ctgagttctg tgaccgccgc ggacaccgcc gtgtattact
      361 gtgcgagata tgagttattt gggaaccaat acaactttga ctactggggc cagggagtcc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002031             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16478:13214
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002031
VERSION     KCXD01002031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16478:13214"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60513.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       439..451
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          109 c          154 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag taacggcatg
      241 cactgggtcc gccaggttcc agggaatgtg ctggagtggg tggcagtgac atcgtttgat
      301 gaaagtaaga aatactacgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagactctta tggaagtggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002032             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6538:6817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002032
VERSION     KCXD01002032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6538:6817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..471
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60514.1"
                     /translation="CARAEYGSNLLPEYFDFW"
     D_segment       404..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..471
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>475
                     /gene="IGHG"
BASE COUNT           92 a          143 c          133 g          107 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcagttgcg ctgtttctgg
      181 aggctccatc agcagtcact tctggaactg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctctg gtattgttgg gaacaccgac tacaacccct ccctcaagag
      301 tcgagtctcc atttcaaaag acacgtccaa gaaccagttc ttcctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagagcg gagtacggta gcaacttgct
      421 ccctgaatac ttcgatttct ggggccaggg cgccctggtc accgtctcct ccgcc
//
LOCUS       KCXD01002033             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18831:23670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002033
VERSION     KCXD01002033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18831:23670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..330
     V_segment       7..255
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>300
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60515.1"
                     /translation="CAGGPSGIWNGWYFDIW"
     D_segment       264..279
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..330
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>333
                     /gene="IGHG"
BASE COUNT           78 a           90 c           94 g           71 t
ORIGIN      
        1 acatgggggg cctcagtgaa ggtctcctgc aaggtttccg gatacacctt caccgactta
       61 tccattcact gggtgcgact ggcccctgga aaagggcttc agtggatcgg aagtgttgat
      121 cctgcatatg gtgaaatgat aaacgcagag aatttccagg gcagagtcac catgaccgag
      181 gacacgtcta cagacacagc ctacatggag ttaagcagcc tgagatctga ggacacggcc
      241 gtgtattact gtgcgggtgg ccctagcggc atctggaacg gctggtactt cgatatctgg
      301 ggccctggca ccccaatcac cgtctcctca acc
//
LOCUS       KCXD01002034             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:24963:10392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002034
VERSION     KCXD01002034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:24963:10392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..511
     V_segment       142..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60516.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       438..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..511
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          111 a          121 c          163 g          118 t
ORIGIN      
        1 acatggggct ctgggagagg agcccaggcc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttggtctga cctgggtttt ccttgttggt
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagc cttggctcag
      181 cctggggggt ccctgagact ctcctgtgca gcgtctgggt tcaccttcag tagctatgcc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagc catatcgttt
      301 gatggaagta agaagaacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aactccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tactactgtt cgagggagtg gatacagtgg gcgcagttag tgagcggttt ggattcctgg
      481 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002035             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20716:7342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002035
VERSION     KCXD01002035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20716:7342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60517.1"
                     /translation="CARYGADYEDDYDYYSFDYW"
     D_segment       405..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          137 c          135 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acttgcgctg tctctggtga
      181 ctccatcacc agtagcttct ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctatggga gtactgggag caccggctac aacccctccc tcaagagtcg
      301 agtctccatt tcaacagaca cgtccaagaa ccagttttcc ctgaatctga actctgtgac
      361 cgccgcagac accgccgtgt attactgtgc gagatatggg gcggattacg aggatgatta
      421 cgattactat agttttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002036             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19501:6462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002036
VERSION     KCXD01002036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19501:6462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60518.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          113 c          158 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagtagtgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctggctg ttgaatcgca
      301 tgatggaaat aagaaatact atgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gagcaacctg aaattggtgg atacggccat
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002037             317 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22548:23783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002037
VERSION     KCXD01002037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 317)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 317)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22548:23783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..315
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..315
     V_segment       8..254
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <249..>284
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60519.1"
                     /translation="CAGGSRRQPENW"
     D_segment       266..273
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..315
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        316..>317
                     /gene="IGHG"
BASE COUNT           59 a           91 c           98 g           69 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc agcggttact
       61 ggtggggctg gatccgccag cccccaggga aggggctgga gtggattggg tatatcggtg
      121 gtactagtgg gagtacctac tacaatccct ccctcgagag tcgagtcacc atttcaacag
      181 acacgtccaa gaatctcttc tccctgaaga tgagttcttt aaccgccgcg gacacggcca
      241 tgtatttctg tgcgggcgga agtcggcggc agccggagaa ctggggccag ggagtcctgg
      301 tcaccgtctc ttcagcc
//
LOCUS       KCXD01002038             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18881:15895
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002038
VERSION     KCXD01002038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18881:15895"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60520.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       431..435
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          107 a          116 c          149 g          120 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt ttctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt tcagcctggg
      181 gagtccctga gactctcctg tgcagcctct ggattcacct tcagtacctc tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgt ctgtaatttc gtctgatgga
      301 agtaagaaat actacgcaga ctctgtgaag gaccgattca ccatctccag agacaactcc
      361 aagaacatac tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtatttc
      421 tgtgtgagag atgccttcgg gggcggtttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002039             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12312:17647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002039
VERSION     KCXD01002039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12312:17647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60521.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          101 a          123 c          161 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagt ttcagtcact acttcatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcagggatta acagtggtgg
      301 ggatactaca taccacgcag actccgtgaa gggcagattc accatgtcca gagagaacgc
      361 caggaacaca ctgtctcttc aaatggacgg cctgagagct gaggactcgg ctgtctatta
      421 ctgtgcgaga gatcgacgtg tacagtcgtt atcttggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002040             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23610:4911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002040
VERSION     KCXD01002040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23610:4911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60522.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          100 a          126 c          161 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag ttcgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggtt tcagcttcag tttctactat
      241 atgacctggg tccgccaggc tccagggaag gggctggagt ggatttcagg tattgacact
      301 ggagggggtg acacctacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga agacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagtagt gggtggtgcc gccggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002041             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14540:17873
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002041
VERSION     KCXD01002041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14540:17873"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60523.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           95 a          137 c          127 g          108 t
ORIGIN      
        1 acatggggag ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gttcccagat gggtcctgtc ccaggtgcag ctacaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcgg caatagctac tggaactgga tccgccagcc cccagggaag ggtctggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattactgtg tgagatatga ggatgaatcc attaactacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002042             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20356:8265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002042
VERSION     KCXD01002042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20356:8265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60524.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       424..430
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          113 a          108 c          138 g          115 t
ORIGIN      
        1 acatggggga agtccacagt gttccattcg gtgatcagca cagaacacag aggactcacc
       61 atgaagtttg ggctgagctg ggttttcctt gttgctgttt taagaggtgt ccagtgtgag
      121 gtccagctgg tggagtctgg aggagacttg gttcagcctg gggggtccct cagactctcc
      181 tgtgcagcct ctggattcac cttcagtaac tatggcatac actgggtccg ccaggctcca
      241 gggaaggggc tggagtgggt ggcagttata tcgtctgatg gaagtaagac atactacgca
      301 aactctgtga aggaccgatt caccatatta agagacaatt ccaagaacat gctatatctt
      361 caaatgaaca acctgaaatt ggaggacacg gccctctatt actgtgcgag agacgatatg
      421 ggaagtggct ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002043             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:24956:3265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002043
VERSION     KCXD01002043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:24956:3265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..482
     V_segment       113..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60525.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       407..411
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          107 a          144 c          134 g           99 t
ORIGIN      
        1 acatgggaac cacatccctc ctctaaagaa gcccctggga gcacagctca tcaccatgga
       61 ctggacctgg aggctcctct ttgtggtggc agcagctgca ggtgtccagt cccaggtcca
      121 cctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaaaa tttcctgcgg
      181 ggcttctgga ttcaccttcg acacccatgg tatcaactgg gtgcgacagg cccctggaca
      241 aggacttcag tggatgggag tgatcatccc ccttattggt atcaccaact acgcaaagaa
      301 ctctcagggc agagtcacac taaccgcgga cacgtccaca aacacagcct acatggagct
      361 gaacagcctg agatttgagg acacggccat ctactactgt gcgagagaac gctgcacttc
      421 tagtgtttgc gccgggttcc ttgactcctg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01002044             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8345:4184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002044
VERSION     KCXD01002044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8345:4184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..514
     V_segment       139..431
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60526.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       434..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          104 a          126 c          158 g          128 t
ORIGIN      
        1 acatggggtc tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtctga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gctttggcga tcatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatccat cagtaatact
      301 ggtaaagccg tacactacgc tgactccgtg aagggccgat tcaccatttc cagagacaac
      361 gccaagaact cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgttgta gcgattacta tagtggtagt tattactatt ggggctacgg cttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002045             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19548:7245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002045
VERSION     KCXD01002045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19548:7245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60527.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          119 a          143 c          137 g           96 t
ORIGIN      
        1 acatggggag agcatcacac aacagccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcaac tgcaggcgcc
      121 cgctctgagg tccagctggt gcaatctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcgaggtttc cggatacacc ttcaccgaac tgtccatcca ctgggtgcga
      241 caggccccag gaaaaggcct tgagtggatg ggaagtgttg atcctgaata tggtgaaatg
      301 ataaacggag aaaaattcca gggcagagtc accttgaccg aggacacgtc tacaggaacg
      361 gcctacatgg agctgatcag tctgagatct gaagacacgg ccgtgtatta ctgtgcgaca
      421 tcacccagcg gcacctggct attttggtac ttcgatttct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01002046             416 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17380:4444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002046
VERSION     KCXD01002046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 416)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 416)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17380:4444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    48..414
                     /note="immunoglobulin heavy chain variable region"
     V_region        48..414
     V_segment       48..344
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <336..>383
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60528.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       359..365
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..414
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        415..>416
                     /gene="IGHG"
BASE COUNT           79 a          131 c          114 g           92 t
ORIGIN      
        1 acatgggctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcacctgc
       61 aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcgcc tgcgctgttt
      121 ctggtgactc catcaacagt ggctactact ggagctggat ccgccaaccc ccagagaagg
      181 ggctggagtg gattgggttt ttcggtggta gtagtggtag cacctactac aacccctccc
      241 tcaagagtcg agtcaccctt tcaaaagaca cgtccaggaa ccagttctcc ctgaaactga
      301 cctctgtgac cgccgcggac acggccgtct attactgtgc gagaaaactt ccaggtctgc
      361 aactaaccgg tttcgattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002047             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22684:10941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002047
VERSION     KCXD01002047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22684:10941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60529.1"
                     /translation="CARVGEDSGGAEDLDFW"
     D_segment       441..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          114 c          156 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagga
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag atacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggaatgggt ggcacttata tcgtatgatg
      301 gagataagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatgtaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag agttggagag gatagtggtg gtgcggagga ccttgacttc tggggccaag
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002048             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22664:6322
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002048
VERSION     KCXD01002048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22664:6322"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60530.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       420..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          108 a          141 c          145 g          109 t
ORIGIN      
        1 acatggggtc acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 ctcaggtcca gctggtgcag tccggggctg agatggagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacaccttca gcatctatgt catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag gcatcttccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga ttaccgcgga cacgtccaca agcacagcct
      361 acatggacct gagcagcctg ggatctgggg acacggccgt gtattattgt gcgagaggtt
      421 actgtactgg tagtggttgt aaccttacat tcaaccggct cgatgtctgg ggcccgggag
      481 tcccggtcac cgtctcctca gcc
//
LOCUS       KCXD01002049             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20286:5722
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002049
VERSION     KCXD01002049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20286:5722"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60531.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          142 c          151 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga gcttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tctattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002050             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18309:15088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002050
VERSION     KCXD01002050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18309:15088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60532.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          124 a          140 c          135 g           96 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      301 atagacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag tctgagatct gaggacacgg ctgtgtatta ctgtgcgaca
      421 tcatccagcg gcacctggct atactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01002051             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4550:13470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002051
VERSION     KCXD01002051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4550:13470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60533.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          106 a          136 c          137 g          106 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag tcccaggtcc
      121 gcctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgcg
      181 gggcttctgg attcaccctc gacacctatg gtatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtggtcatcc cccttattgg tatcataaac tacgcaaaga
      301 actctcaggg cagactcaca ataaccgcga acacgtccac aaatacagcc tatttggaac
      361 tgagcagtct gagatctgag gacacggcca tttattactg tgcgagagaa tactgtactt
      421 ctagttcttg cgccgggttc cttgactact ggggccaggg agccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01002052             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19978:15660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002052
VERSION     KCXD01002052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19978:15660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60534.1"
                     /translation="CARGVTPDVFGFLGLGYW"
     D_segment       418..423
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          141 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gcagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagaggt
      421 gtcacaccag acgtcttcgg tttcctcggg cttggctact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002053             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9008:10197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002053
VERSION     KCXD01002053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9008:10197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60535.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          125 c          160 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggcggggag agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01002054             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17825:8222
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002054
VERSION     KCXD01002054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17825:8222"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..359
     V_segment       7..278
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <275..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60536.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       294..301
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..359
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           83 a           91 c          101 g           86 t
ORIGIN      
        1 acatggggag tctgggggag gcttggtaca gcctggggcg tccctgaagc tctcctgtgc
       61 agcctctgag ttcaccttca gtgactatga catgcactgg gttcgccagg ctccagggaa
      121 gggtctagaa tgggtatcag gtattaacat tggcggtgac ccatactacc cagactctgt
      181 gaagggtcga ttcaccatct ccagagacaa cgccaagaac tccttgtatc ttcaaatgaa
      241 caacctgaga cctgaggaca ctgctgtgta ttattgtgtg agggggatgg ataactacca
      301 cttcagtaat acggactttg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      361 c
//
LOCUS       KCXD01002055             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11742:3671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002055
VERSION     KCXD01002055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11742:3671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60537.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          111 c          154 g          118 t
ORIGIN      
        1 acatgggggg tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002056             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21254:7355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002056
VERSION     KCXD01002056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21254:7355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60538.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          135 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg gagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002057             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23551:6344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002057
VERSION     KCXD01002057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23551:6344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..478
     V_segment       118..411
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60539.1"
                     /translation="CSRADIAAAASFDLW"
     D_segment       418..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          117 a          141 c          126 g           96 t
ORIGIN      
        1 acatggggca acaactgcat ccaacctcaa gagaagcccc tgagagcaca gtttcgcacc
       61 atggacttga cctggaagat cctcctcttg gtgacagcag ccacaggtgc ccactcccag
      121 gtgcaactgg ttcagtctgg ggctgagatt aagcagcctg gggcctcagt gaagctctcc
      181 tgcaaggctt ctggatatac cttcactaac tactacatac actgggtgag acaggcccct
      241 ggacaaggcc ttgagtggat aggactgatc tccccttata atggttacaa atcggccgca
      301 cagagcgtcc agggcagagt caccataagt gcggacatgt ccacgagcac aggctacatg
      361 gaactaacca gcctgagatc tgaggacaca gccgtgtatt actgttcgag agcagacata
      421 gcagcggctg cctcctttga cctctggggc cagggagtcc tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01002058             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11028:19084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002058
VERSION     KCXD01002058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11028:19084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..471
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60540.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       417..422
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          142 c          133 g          105 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 ggtcgggccc agggctggtg aagccttcgg agaccctgtc cctcacctgc gctgtttctg
      181 gtgactccat caacagtggc tactactgga gttggatccg ccaaccccca gggagggggc
      241 tggagtggat tgggtctatc ggtggtagta gtggcagcac ctactacaac ccctccctca
      301 agagtcgagt caccctttca aaagacacgt ccaggaacca gttctccctg aaactgagct
      361 ctgtgaccgc cgcagacacg gccgtttatt actgtgcgag aaaacttcca ggtctccaac
      421 taaccggttt cgattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002059             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10156:17871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002059
VERSION     KCXD01002059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10156:17871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60541.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          113 c          151 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacagctgg tggagtctgg aggagacttg gttcaccctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccagggtcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaggac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gatatttctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtcc
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002060             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:16479:16874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002060
VERSION     KCXD01002060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:16479:16874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..395
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60542.1"
                     /translation="CASLGLIEQEGVNSW"
     D_segment       419..424
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..463
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           98 a          122 c          134 g          111 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgga agaacatgaa gcacctgcgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtaca actgcaggag
      121 tcgggcccag gagtggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctgga
      181 ggctctatca gcagtggtta tgactggagt tggatccgcc agcccccagg gaaggggcta
      241 gagtggattg gatatatcca tggtagtcgt ggaatcaatt ataagccgtc cctcaagaat
      301 cgagtcacta tttcaaaaga cgcgtccaag aatcagtttt ccctgaagct gagctctatg
      361 accgccgcgg acacggccgt ctattactgt gcgagccttg gtttaattga acaggagggt
      421 gtgaattcct ggggccaagg ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01002061             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14419:14341
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002061
VERSION     KCXD01002061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14419:14341"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60543.1"
                     /translation="CVRGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          113 c          150 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga tttaccttca gtaactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggat tgggtggcag ttacgtcgtt
      301 tgatgaaaat gtgaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtattactgt gtgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002062             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:11521:13140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002062
VERSION     KCXD01002062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:11521:13140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..483
     V_segment       111..404
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <396..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60544.1"
                     /translation="CAKRGWGGSWNGGHYFDYW"
     D_segment       415..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          101 a          120 c          153 g          111 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatggagt
       61 ctgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggtccagc ctggggggtc tctgagactc tcctgtgcag
      181 cctctggatt cactttcagt agctatgcca tgacctgggt ccgccaggct ccagggaagg
      241 ggctggagtg ggtctcatac attactaatg gtggtgttac cacatactac gcagactccg
      301 tgaagggccg attcaccatc tccagagaca actcgatgga cacgctctcc ctgcaaatga
      361 acagcctgag aactgaggac acggccgtct attactgtgc gaaaagaggg tggggcggca
      421 gctggaacgg ggggcactac tttgactatt ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01002063             388 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5062:9619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002063
VERSION     KCXD01002063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 388)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 388)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5062:9619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..386
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..386
     V_segment       20..311
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>355
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60545.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       325..331
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       335..386
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        387..>388
                     /gene="IGHG"
BASE COUNT           94 a          102 c          112 g           80 t
ORIGIN      
        1 acatgggggc gcccactctg aggtccagct ggtgcagtct ggggctgagg tgaagaagcc
       61 tggggcctca gtgaaggtct cctgcaacgt ttccggatac atcttaaccg aattatccat
      121 acactgggtg cgacaggccc ctggaaaagg gcttgagtgg atgggaagtg ttgatcctca
      181 atatggtgaa atgatagacg cagagaaatt ccagggcaga gtcaccatga ccgaggacac
      241 gtctacagac acagcctaca tggagctgag cagtctgaga tctgaggaca cggccgtgta
      301 ttactgtgcg acatcatcca gcggcacctg gctatactgg tacttcgata tctggggccc
      361 tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002064             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:15840:15669
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002064
VERSION     KCXD01002064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:15840:15669"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60546.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       412..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          100 a          139 c          143 g           99 t
ORIGIN      
        1 acatgggggg catcacacaa cagccacttc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cgtcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgtatatg gtgaaatggt
      301 gttccagggc ggggtcacca tgaccgagga cacgtctaca gacacagcct acttggagct
      361 gaacagcctg aggtatgaag acacggccgt gtattactgt gcgattggcc ctagcggcat
      421 ctggaacggc tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01002065             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16356:10449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002065
VERSION     KCXD01002065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16356:10449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60547.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       413..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          107 a          145 c          137 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggccccagg aagaggcctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tatattactg tgcgatcggc cctagcggca
      421 gttggaacgc ctggtccttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01002066             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18919:19710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002066
VERSION     KCXD01002066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18919:19710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60548.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          113 c          145 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aattggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgagg ctctcctgtg cagcctctgg attcaccttc agtaattatg
      241 gcttccactg ggtccgccag gctccagtga aggggctgga gtgggttgca gttatttcgt
      301 atgatgaaaa tgtgaaatac tacgcagact ctgtaaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002067             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23275:17141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002067
VERSION     KCXD01002067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23275:17141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..428
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60549.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       377..382
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       386..428
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT           90 a           93 c          135 g          112 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc agcctggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactttg gcatccactg
      181 ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt atgatgtaac
      241 tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag acaattccaa
      301 gaacacgcta tatcttcaaa tgcacaacct gaaattggag gacacggccg tgtattattg
      361 tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc tggtcaccgt
      421 ctcgtcagcc
//
LOCUS       KCXD01002068             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:25389:19201
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002068
VERSION     KCXD01002068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:25389:19201"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60550.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          118 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcccaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggactgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002069             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11575:7719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002069
VERSION     KCXD01002069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11575:7719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60551.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       434..440
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          143 c          141 g           97 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccaact ggtgcagtct ggggctgaaa tgaagaagcc tggggcctca gttagggtct
      181 cctgcaaggt ttccggaaac accttcaccg aattatccat gcactggctg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggatgtg tcgatcctgc acaaggtgaa ataatacacg
      301 cagagaaatt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagccttca
      361 tggagttgag cagcctgaga tctgaggaca cggccgtgta tttctgtgcg aaaggggggt
      421 tcggaaccag cgtctggtcc aacctcttct acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002070             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16842:7581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002070
VERSION     KCXD01002070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16842:7581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60552.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           91 a          139 c          129 g          108 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtcaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cagtagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaggagtc
      301 gagtctccat ttcaacagac acgtccaaga accacttttc cctgaggctg cgttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002071             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:11910:11821
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002071
VERSION     KCXD01002071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:11910:11821"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..348
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60553.1"
                     /translation="CARYEAGTTLIDYW"
     D_segment       290..301
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           72 a          108 c           98 g           72 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg
       61 tctctggtga ctccgtcacc agcacctact ggagctggat ccgccagccc ccagggaaag
      121 gactggagtg gattggctat atctatggtg gtagtgggag taccggctac aacccctccc
      181 tcaggagtcg agtcgacatt tcgacagaca cgtccaacaa ccagttttcc ctgaagctga
      241 gctctgtgac cgccgcggac accgccgtct actactgtgc gagatatgaa gctggaacaa
      301 ccctaattga ctactggggc cagggagtcc tggtcatcgt ctcctcagcc
//
LOCUS       KCXD01002072             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19092:18394
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002072
VERSION     KCXD01002072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19092:18394"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60554.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       442..453
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          117 c          154 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca ttgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccttgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcca ggctccaggg aagggtctgg agtgggtggc agttatgtcg
      301 catgatggaa ctaagaaatt ctacgcagac tctgtgaagg accgattcac catctccagg
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgagattgga ggacgcggcc
      421 gtctattatt gtgcgagagg agactacggt aacagccttg acttctgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01002073             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:9507:4595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002073
VERSION     KCXD01002073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:9507:4595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60555.1"
                     /translation="CVRYEDEAINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc cccccgggaa gggactggaa
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcagca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaagc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002074             359 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20701:10112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002074
VERSION     KCXD01002074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 359)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20701:10112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..357
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..357
     V_segment       8..281
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <273..>326
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60556.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       290..298
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       310..357
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        358..>359
                     /gene="IGHG"
BASE COUNT           71 a          104 c          104 g           80 t
ORIGIN      
        1 acatgggggg cccaggactg gtgaagcctt cggagaccct gtccctctcc tgcactgtct
       61 ctggtggctc cttcagtggt tactactgga gctggatccg ccagccccca gggaaggggc
      121 tggagtggat tgggtttatc ggtggtggta gtgggagcac cgaatacaac ccctccctca
      181 aaagtcgagt caccatttca agagacacgt ccaaaaatca attctccctg aagctggcct
      241 ctatggccgc cgcggacacg gccgtttatt tctgtgccag agatgcggga gtgggagcca
      301 caatccttta ctactatgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002075             336 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21125:6919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002075
VERSION     KCXD01002075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 336)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 336)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21125:6919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..334
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..334
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>303
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60557.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       269..285
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..334
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        335..>336
                     /gene="IGHG"
BASE COUNT           80 a           81 c           96 g           79 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ccttatatcg
      121 tttgatggaa ctaagcaata ctacgcagac tctgtgaagg accgattcac catttcaaga
      181 gacaattcca agaacatgct atatcttcaa atgaagaacc tgaaattggg ggacacggcc
      241 gtgcattact gtgcgagagt tagtggtcat acagagggta cagttgaata ctttgactac
      301 tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002076             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18928:4070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002076
VERSION     KCXD01002076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18928:4070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..478
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60558.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       416..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           96 a          143 c          138 g          103 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccaaat gcgtcctgtc ccaggtgcag
      121 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct
      181 gtctctggtg gctccttcag caacttctac tggaactgga tccgccagac cccagggaag
      241 gggctggagt ggattgggtg tatcagtggt gatagtggga gcaccgacta caacccctcc
      301 ctcaagagtc gagtccacat ttcgacagac acgtccaaga aacagttctc cctgaagatg
      361 agctctgtga ccgccgcgga cacggccgtg tattactgtg cgagagaccc ccggtggcag
      421 ctggaactcc tcttctttga ctattggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002077             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:8550:9584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002077
VERSION     KCXD01002077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:8550:9584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..329
     V_segment       8..257
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60559.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       267..284
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           74 a           97 c           89 g           71 t
ORIGIN      
        1 acatgggggg gaatctctga ggatctcctg taagacttct ggatacagct ttaccagtta
       61 ctggatcagt tgggtgcgcc agatgcccgg gaaaggcctg gagtggatgg gaatgatcta
      121 tcctagtgat tctgatccca gatacagccc gtccttccaa ggccaggtca ccatctcagc
      181 cgacaagtcc atcagcaccg cctacctgca gtggaacagc ctgaaggcct cggacaccgc
      241 cacgtattac tgtgcgagag ctggacgata cacctacagt tacccctttg actactgggg
      301 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002078             355 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5925:15228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002078
VERSION     KCXD01002078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 355)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 355)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5925:15228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..353
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..353
     V_segment       8..278
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>322
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60560.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       292..298
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..353
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        354..>355
                     /gene="IGHG"
BASE COUNT           90 a           91 c          101 g           73 t
ORIGIN      
        1 acatgggggg gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaacgtttc
       61 cggatacatc ttaaccgaat tatccataca ctgggtgcga caggcccctg gaaaagggct
      121 tgagtggatg ggaagtgttg atcctcaata tggtgaaatg atagacgcag agaaattcca
      181 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag
      241 tctgagatct gaggacacgg ccgtgtatta ctgtgcgaca tcatccagcg gcacctggct
      301 atactggtac ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01002079             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11186:22348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002079
VERSION     KCXD01002079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11186:22348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..460
     V_segment       91..384
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60561.1"
                     /translation="CARERCSASSCAGFLDSW"
     D_segment       390..397
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           98 a          129 c          142 g           93 t
ORIGIN      
        1 acatgggggc ccctgggagc acagctcatc accatggact ggacctggag gctcctcttt
       61 gtggtggcag cagctacagg tgtccagtcc caggtccagc tggtacagtc cggggctgag
      121 gtgaagaagc ctggggcctc agtgaaagtt tcctgcaagg cttctggatt caccctcgac
      181 aactatggca tcaactgggt gcgccaggcc cccggacagg ggcttgagtg gatgggagtg
      241 atcatccccc ttattggaat aataaactac gcagagaacg tccagggcag agtcgcgatt
      301 tccgcggaca cgtccataaa tacagcctac atggaggtgc gcagcctgag atctgaggac
      361 acggccatct attactgtgc gcgagaacgt tgtagtgcta gcagttgcgc cggattccta
      421 gactcctggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002080             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17611:12866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002080
VERSION     KCXD01002080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17611:12866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..484
     V_segment       139..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60562.1"
                     /translation="CANGMSGLDYW"
     D_segment       429..433
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          103 a          118 c          154 g          111 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagcactgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg ggggcggctt ggcaaagcct
      181 gggggatcct tgagactctc ctgtgcagcc tctggattca ccttcagtcg ctatgctatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tctcaggtat tagtagtggt
      301 ggtaacacat acttcgcaga ctccgtgaag ggccgattca ccatctccag agacgactca
      361 aagaacacag tctccttgca aatgaacagt ctgagacctg aagacacggc cgtgtattac
      421 tgtgcgaatg ggatgtcagg gcttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01002081             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19852:16185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002081
VERSION     KCXD01002081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19852:16185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..491
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60563.1"
                     /translation="CARADRGSSIDYW"
     D_segment       442..448
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          113 a          115 c          150 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaagactc accatgaagt ttgggctgag ttgggttttc cttgttgcaa
      121 ttttaagagg tgtccagtgt ggggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgtag cctctggatt caccttcaga acctatggca
      241 tgcactgggt ccgccaggcc ccagggaagg ggctggagtg ggtggcggtt atatcatatg
      301 atgatgacaa gaaatattac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cattctttat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 tttattgtgc gagagcggat cgcggcagtt caattgacta ctggggccag ggagtcctgg
      481 tcaccgtctc cccagcc
//
LOCUS       KCXD01002082             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:26150:9215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002082
VERSION     KCXD01002082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:26150:9215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..256
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <248..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60564.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       262..269
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..326
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           74 a           93 c           85 g           76 t
ORIGIN      
        1 acatgggggg ggatccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
       61 tgctatgcat tgggtccgcc aggctccagg gaaggggctg aaatgggtct catctattag
      121 tagtggtggt ctcacatact acgcagactc cgtgaagggc cgatttgcca tctccagaga
      181 caactcaaag aacacgctct ccctgcaaat gaacagcctg agcgctgagg acacggccgt
      241 atattactgt gcgaaaggag gtagcagctc tttctattgg tacttcgata tctggggccc
      301 tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002083             293 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14054:15475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002083
VERSION     KCXD01002083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 293)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 293)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14054:15475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..289
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..289
     V_segment       8..206
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>260
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60565.1"
                     /translation="CARGGFGTSVWSNLFYGLDSW"
     D_segment       227..233
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       242..289
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        290..>293
                     /gene="IGHG"
BASE COUNT           65 a           72 c           93 g           63 t
ORIGIN      
        1 acatgggatt catgcactgg gtgcgacagg cccctggaaa agggcttgag tggatgggag
       61 gtgtcgatcc tgctcaaggt gaaataatat acgcagagaa attccagggc agagtcacca
      121 tgaccgagga cacgtctaca gacacagcct tcatggagtt gagcagcctg agatctgagg
      181 acacggccgt gtatttctgt gcgagagggg ggttcggaac cagcgtctgg tccaacctct
      241 tctacggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctct gcc
//
LOCUS       KCXD01002084             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7779:6409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002084
VERSION     KCXD01002084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7779:6409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..405
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60566.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       410..423
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           93 a          133 c          145 g          106 t
ORIGIN      
        1 acatgggggg ggaaatgctc tctgagagtc atggacctcc tgtgcaagaa catgaagcac
       61 ctgtggttct tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcagctg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcac ttgcgttgtc
      181 tctggccact ccatcagcag tggctaccac tggggctgga tccgtcagcc cccagggaag
      241 ggactggact atattggcta tatcagtggt agtagtggga gcacctacta caagccctcc
      301 ctcatgagtc gagtcatcat ttcaagagac acgtcccgga atgagttctc cctgaggctg
      361 aggtctgtga ctgtcgcgga cacggccgtg tattattgtg cgagacgaga tagctggaac
      421 aacgggggga gccttgacta ctggggccag ggattcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002085             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22392:9192
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002085
VERSION     KCXD01002085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22392:9192"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60567.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          124 a          141 c          134 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccaa ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 cgtccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01002086             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12747:8836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002086
VERSION     KCXD01002086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12747:8836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60568.1"
                     /translation="CARGLPTVFGMVITELW"
     D_segment       410..425
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..467
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           87 a          140 c          133 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc gcttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggcat ataagtgtca gtcttgggag caccgcctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagttga actctgtgac
      361 cgccgcggac acggccgtgt ttttttgtgc gagaggactt cctacagttt ttggaatggt
      421 tattacggaa ctctggggcc cgggagtcct gttcaccgtc tcctcagcc
//
LOCUS       KCXD01002087             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:8965:6562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002087
VERSION     KCXD01002087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:8965:6562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..481
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60569.1"
                     /translation="CTRHVGAYIAPTGLRYFDYW"
     D_segment       430..437
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           97 a          137 c          139 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca aggacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctaat
      181 tactccacca gcaaaggtta ctactggggc tggatccgtc agtccccagg gaagggactg
      241 gagtatattg ggtatatcag tggtagtagt gggagcacct actacaagcc ctccctcatg
      301 agtcgagtca ccatctcaaa agacacgtcc aggaagcagt tctccctgaa gctgagctct
      361 gtgacggccg cggacacggc cgtgtattac tgtactagac atgtgggggc gtatattgca
      421 ccgactggtc tacggtactt tgactactgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01002088             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6297:10130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002088
VERSION     KCXD01002088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6297:10130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60570.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       436..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          115 c          154 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca tcttcagtag cctcggcatg
      241 cactgggtcc gccgggctcc agggaagggg ctggagtggg tggcagttat ctcgtctgat
      301 ggaagtcaga aatattatgc agactctatg aaggaccgat tcaccatctc cagagacaat
      361 gccaagaaca tgctgtatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga gaggggaata cagtaactct attgactact ggggccgggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002089             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21683:12883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002089
VERSION     KCXD01002089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21683:12883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60571.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          120 a          114 c          151 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta catcttcaaa tgaacaacct gaaattggag gacacggcca
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002090             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13076:9190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002090
VERSION     KCXD01002090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13076:9190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..492
     V_segment       120..413
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60572.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       423..434
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT           94 a          147 c          144 g          109 t
ORIGIN      
        1 acatggggct ccctcaccgc acagctggga tctcagtgct tccttttctg tcctccacca
       61 cgatggggtc aactgccatc ctcaccctcc tactggctgt tctccaagga gtctgtgccg
      121 aggtgcagct ggtgcagtct ggagcagagg tgaaaaggcc cggggagtct ctgaagatct
      181 cctgtaagac ttctggagac acctctacct actattggat cagctgggtg cgccagatgc
      241 ccgggaaagg cctggagtgg atgggggcga ttgatcctgg tgattctgat accaaatata
      301 gtccgtcctt ccaaggccag gtctccatct cagccgacaa gtccatcagc accgcctacc
      361 tgcagtggag cagcctgaag gcctcggaca ccgccacgta ttactgtgcg aaaggggggt
      421 ggtggggtga ttatccaccc tcagactggc tcgatgtctg gggcccggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002091             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15438:11612
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002091
VERSION     KCXD01002091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15438:11612"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60573.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          112 a          144 c          133 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agccggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca agatttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agtagcctga catctgagga cacggccgtg tattactgtg cgactggccc tagcggcacc
      421 tggaacgcct ggtacctcga tatctggggc cctggcacct caatcaccat ctcctcagcc
//
LOCUS       KCXD01002092             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21232:4538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002092
VERSION     KCXD01002092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21232:4538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..472
     V_segment       109..401
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60574.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       414..422
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          131 c          142 g          105 t
ORIGIN      
        1 acatgggggg ggaaatgttc tctgagagtc acggacatcc tgtgcaagaa catgaagcac
       61 ctgtggttct tcctcctcct ggtggcagct cccagatggg tcctgtccca gctgcagctg
      121 caggagtcgg gcccagggct ggtgaagcct ccggagaccc tgtccctcac ctgcgctgtc
      181 tctggtggct ctatcagcag tagttactgg agctggatcc gccagacccc agggaaggga
      241 ctggagtgga ttgggtatat ccatgggagt gatagtagta ccaagtacaa cccctccctc
      301 aagagtcgag tcaccctgtc agtagacacg tccaagaatc aatgctccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtgtat tattgtgcga gttcgggtat agaagtggtt
      421 gcctacagta ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002093             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22021:10702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002093
VERSION     KCXD01002093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22021:10702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60575.1"
                     /translation="CARWSAANFDSW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          135 c          136 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatccgc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tgtatctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaatgg acacgtccaa gaaccagttc tccctggagc tgaggtctat
      361 gaccgccgcg gacacggccg tgtatcactg tgcgagatgg tcggcagcca actttgactc
      421 ctggggtcag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002094             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23797:15574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002094
VERSION     KCXD01002094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23797:15574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60576.1"
                     /translation="CAGAHSGSWTNWSFDLW"
     D_segment       423..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          141 c          145 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggagggtcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagccagggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatattcggt caccgaagtg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctctatatg gtgaaataat
      301 agaaggagag aagttcccgg gcagagtcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgggagc
      421 ccatagcggc agctggacca actggtcctt cgatctctgg ggccctggca ctccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002095             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16373:6912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002095
VERSION     KCXD01002095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16373:6912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60577.1"
                     /translation="CARSPSGNWLYWFFDFW"
     D_segment       424..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          147 c          130 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattt tccatccact ggctacgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgtttttg gtgaaataat
      301 tcacgcagag atattccaga acagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgcgatc
      421 acccagcggc aactggctat actggttctt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002096             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16793:17918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002096
VERSION     KCXD01002096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16793:17918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60578.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       428..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          107 a          139 c          153 g          104 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgccctct
      121 ctgaggtcca actggtgcag tctggggctg aggtgaggaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga gacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggttgggag gtgttgatcc tgcaaatggt gaggtaatac
      301 acgcagatag ttttcagggc agagtcacca tgaccgagga cacgtctaca ctcacagcct
      361 acatggagct gagcggcctg agatctgagg acacggccgt gtattactgt gcgagagggc
      421 ggttcggtag cagcgtctgg tccaatctcg tctatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002097             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24139:7237
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002097
VERSION     KCXD01002097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24139:7237"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60579.1"
                     /translation="CARGTRVWGYFPLDVW"
     D_segment       434..440
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          132 c          145 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctgttgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatcct caccgaattt tccattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctggatatg gtgaaatgat
      301 acacgcagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ttgagcagcc tgagatctga ggacacggcc gtctattact gtgcgagagg
      421 cacaagggtg tggggttatt tcccgttgga tgtctggggc cggggagttc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002098             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19307:19671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002098
VERSION     KCXD01002098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19307:19671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60580.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       436..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          111 c          146 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaattg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgaggctctc ctgtgcagcc tctggattca ccttcagtaa ttatggcttc
      241 cactgggtcc gccaggctcc agtgaagggg ctggagtggg ttgcagttat atcgtatgat
      301 gaaaatgtga aattctacgc agactctgta aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtacga gaggggaata cagtaactct attgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002099             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:10986:16002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002099
VERSION     KCXD01002099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:10986:16002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..348
     V_segment       8..260
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60581.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       270..291
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           73 a          103 c           90 g           84 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacatgcg ctgtctctgg tggctctatc agcagtacta
       61 aatggtggag ctggatccgc cagcccccag ggaaagggct ggagtggatt ggctatatca
      121 gtggtagtag tgctaacacc tactacaacc cctccctcaa gagtcgagtc accatttcaa
      181 cggacacgtc caacaaccag ttctccctga agctgagctc tgtgaccgcc gcggacacgg
      241 ccgtttatta ttgtgcgaga tcccaatcct attgtagtgg gctttactgc ttcggctact
      301 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002100             364 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12608:4017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002100
VERSION     KCXD01002100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 364)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 364)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12608:4017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..362
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..362
     V_segment       1..286
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <278..>331
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60582.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       287..291
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..362
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        363..>364
                     /gene="IGHG"
BASE COUNT           81 a          105 c          102 g           76 t
ORIGIN      
        1 cctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaaaa tttcctgcgg
       61 ggcttctgga ttcaccttcg acacccatgg tatcaactgg gtgcgacagg cccctggaca
      121 aggacttcag tggatgggag tgatcatccc ccttattggt atcaccaact acgcaaagaa
      181 ctctcagggc agagtcacac taaccgcgga cacgtccaca aacacagcct acatggagct
      241 gaacagcctg agatttgagg acacggccat ctactactgt gcgagagaac gctgcacttc
      301 tagtgtttgc gccgggttcc ttgactcctg gggccaggga gtcctggtca ccgtctcctc
      361 agcc
//
LOCUS       KCXD01002101             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:9292:16525
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002101
VERSION     KCXD01002101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:9292:16525"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60583.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          120 c          150 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgagact aagaaatact acgcagactc tgtgaagggc cgattcacca tctccagaga
      361 caattccaaa aacatgctat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002102             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19070:19751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002102
VERSION     KCXD01002102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19070:19751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60584.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          137 c          128 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttcta ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac tccgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002103             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11064:19195
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002103
VERSION     KCXD01002103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11064:19195"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60585.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       445..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          120 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcttctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgcctgg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg aaattgaagg acacggccgt
      421 gtactactgt gggagagatg ataatggggt gattatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002104             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5250:12464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002104
VERSION     KCXD01002104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5250:12464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60586.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       409..415
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          135 c          141 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gaatatggtg aaatgacgtt
      301 ccaggggaga gtcaccatga ccgaggacac gtctacagac acggcctaca tggagctgag
      361 tagcctgaga tctgaggaca cgggcgtgta ttactgtgcg attggcccta gcggtaggtg
      421 gaaccactgg tccttcgaga tctggggacc tgggacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002105             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13514:18018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002105
VERSION     KCXD01002105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13514:18018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..309
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..309
     V_segment       8..248
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60587.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       261..267
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       268..309
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        310..>311
                     /gene="IGHG"
BASE COUNT           83 a           73 c           84 g           71 t
ORIGIN      
        1 acatggggag actctcctgt gcagcctctg gattcacctt cagtaactat ggcatacact
       61 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg tctgatggaa
      121 gtaagacata ctacgcaaaa tctgtgaagg accgattcac catattaaga gacaattcca
      181 agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc ctctattact
      241 gtgcgagaga cgatatggga agtggctttg actactgggg ccagggagtc ctggtcaccg
      301 tctcctcagc c
//
LOCUS       KCXD01002106             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:19991:5163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002106
VERSION     KCXD01002106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:19991:5163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60588.1"
                     /translation="CSRWGTPFDYW"
     D_segment       401..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           92 a          133 c          130 g          102 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga agcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcttg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tagctccatc aacagtggtt atgcctggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtgggtt gggcatatct atgatagtag tggaaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga agttgaattc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgttcgaga tgggggaccc cctttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002107             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12060:13962
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002107
VERSION     KCXD01002107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12060:13962"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60589.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          114 c          158 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagtagtgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctggctg ttgaatcgca
      301 tgatggaaat aagaaatact atgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtct ttcttcaaat gagcaacctg aaattggtgg atacggccat
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002108             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11727:13660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002108
VERSION     KCXD01002108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11727:13660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60590.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           88 a          138 c          134 g           97 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcgctg tccctggtgg
      181 ctccatcaac agtggttatg gctggagctg ggtccgccag cccccaggga aggggctgga
      241 gtggattggg tgtctctatg atagtagtgg gaacacgtac tacaacccct ccctcaagag
      301 tcgcgtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaacc tgaggtctat
      361 gaccgccgcg gacacggccg tctattactg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002109             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15324:18531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002109
VERSION     KCXD01002109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15324:18531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60591.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       438..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          131 c          150 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagcctc tcctgtgtag cctctggatt caccttcagt acctattcca
      241 tacactgggt ccgccagact ccagggaagg ggctggagtg ggtctccgct attagtactg
      301 ctggtagcac atactacaca gactccgtga agggccgatt caccatctcc agagacaact
      361 cacagaacac gctctccctg caaatgaaca gcctgagagc tgaggacacg gccctgtatt
      421 actgtgcgaa aggggagaca gcttcagttt attacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002110             415 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22001:14639
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002110
VERSION     KCXD01002110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 415)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 415)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22001:14639"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    59..413
                     /note="immunoglobulin heavy chain variable region"
     V_region        59..413
     V_segment       59..336
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <332..>382
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60592.1"
                     /translation="CAAGHSGTWNHWYFDVW"
     D_segment       352..361
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       363..413
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        414..>415
                     /gene="IGHG"
BASE COUNT           99 a          112 c          121 g           83 t
ORIGIN      
        1 acatgggtgg acctggagga tcctcctctt ggtggcagca gcgacaggcg cccactctga
       61 ggtccaacta atgcagtctg gggctgaggt gaagaagcct gggacctcag ttaaggtctc
      121 ctgcaaggtt tccggataca ccttcagcga attatccata cactgggtgc gacaggcccc
      181 tggaaaaggg cttgagtggg tggcaagtgt tgaccctgca tatggtgaaa tgaaacacgt
      241 agacagggtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag
      301 cctgagatct gaggacacgg ccgtgtatta ctgtgcagcc ggacatagtg gcacctggaa
      361 ccactggtac ttcgatgtct ggggccctgg caccccaatc accatttcct cagcc
//
LOCUS       KCXD01002111             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10778:16446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002111
VERSION     KCXD01002111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10778:16446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60593.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          115 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtcactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaagttc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002112             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9869:3970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002112
VERSION     KCXD01002112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9869:3970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60594.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       424..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          144 c          135 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccccc
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca cagtttccgg agacaccttc accgaattat cgttgcactg ggtgcgccag
      241 gcccctggaa aagggcttga gtgggttgga agtgttgatc ctgcatatgg tgaaatgata
      301 cacacagaga aattccaggg cagaatcacc atgaccgagg acacgtctat agacacagcc
      361 tacatggagc taagcagcct gatttctgag gacacggccg tgtattactg tgcgatttca
      421 tccagcggca gctggctgtt ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002113             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18412:8030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002113
VERSION     KCXD01002113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18412:8030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..347
     V_segment       8..271
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <263..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60595.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       272..280
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       313..347
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>349
                     /gene="IGHG"
BASE COUNT           78 a           89 c          108 g           74 t
ORIGIN      
        1 acatggggtg aggaagcctg gggtctcagt aaaggtctcc tgcaaggttt ccggaaacac
       61 catcaccgaa ttatccgtgc actgggtgcg acaggcccct ggaaaaggcc ttgagtggat
      121 ggggggtgtt gatcccgtct atggtgaaat aagacacgca gagaacttcc agggcagagt
      181 caccatgacc gaggacacgt cgacagacac agcctacatg gagctgagca gcctgagatc
      241 tgaggacacg gccgtctatt actgtgcgcg aggatattgt catggtagtt actgttcctc
      301 gggtcttgtc tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002114             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15003:11612
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002114
VERSION     KCXD01002114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15003:11612"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..465
     V_segment       93..389
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <381..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60596.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       401..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           91 a          136 c          140 g          100 t
ORIGIN      
        1 acatggggag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcgggag tcgggcccag
      121 cagtggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt gactccatca
      181 ccagtagtaa ttggtggagc tggatccgcc agtccccagg gaagggactg gaatggattg
      241 ggggtatcta tggtagtggt gggaataccg aatacaaccc ctccctcaag agtcgagtca
      301 ccatttcaaa ggacacgtcc aagaaccagt tctccctgaa gctgaactct gtgaccgccg
      361 cggacaccgc cgtgtattac tgtacgagag aatggggcgc tatagcggca gttgggcctg
      421 tccttgcctc ctggggccag ggtgtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002115             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:9135:22277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002115
VERSION     KCXD01002115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:9135:22277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60597.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          112 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgaaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002116             299 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19785:10352
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002116
VERSION     KCXD01002116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 299)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 299)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..299
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19785:10352"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..297
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..297
     V_segment       8..230
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <225..>266
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60598.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       239..248
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       256..297
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        298..>299
                     /gene="IGHG"
BASE COUNT           54 a           87 c           90 g           68 t
ORIGIN      
        1 acatgggtgt ctctggtggc tccatcagtg gttactggtg gggctggatc cgccagtccc
       61 cagggagggg gctggaatgg attggatttt tcggtggtag tggtgggaac acctactaca
      121 agtcctccct ccagagtcga gtcaccattt cagccgaccc gtccaagaac cagttctccc
      181 tgatactgac ctctgtgacc gccgcggaca cggccctcta ttactgtgcg cgggggaata
      241 tagcagcgac tggcattgac tactggggcc agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002117             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19844:12407
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002117
VERSION     KCXD01002117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19844:12407"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60599.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagttttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gccccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattattg tgcgagagga gactacggta acagccttga cttctggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01002118             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13884:5261
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002118
VERSION     KCXD01002118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13884:5261"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60600.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          122 c          149 g          118 t
ORIGIN      
        1 acatggggga ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaaa taacctatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagat tcatatggca gcggctccga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002119             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9800:8429
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002119
VERSION     KCXD01002119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9800:8429"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..484
     V_segment       106..405
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60601.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       417..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          103 a          134 c          137 g          112 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcatg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg cgttgtctct
      181 ggctactccg tcagcagtgg ttattactac tggggctgga tccgtcagcc cccagggaag
      241 gggctggagt ggattgggta tattggtggt tatagtggga acaccaacta caacccctcc
      301 ctcaagagtc gacttaccat ttcaaaagac acgtccaaga accagttctc cctgaagttg
      361 aactctgtga ccgccgcgga cacggccgtg tatcactgtg cgagacatgg aggtttctat
      421 agtgcgactg ataagtcaac atttgacaac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01002120             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20682:5969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002120
VERSION     KCXD01002120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20682:5969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60602.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       427..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          140 c          140 g          102 t
ORIGIN      
        1 acatggggga ctcaacaact gcatccaacc tcaagagaag cccctgagag cacagtttct
       61 caccatggac ttgacctgga agatcctcct cttggtgaca gcagccacag gtgcccactc
      121 ccaggtgcaa ctggtgcagt ctgggggtga gattaagcag cctggggcct cagtgaagct
      181 ctcctgtcag gcttctggat attccctcac tcactacttc atgcactggg tgagacaggc
      241 ccctggacag ggccttgagt ggataggact gatcacccct cacaatgatc ataaagtcta
      301 cgcacagaac ttccagggca gagtcaccat aactacggac acgtccacga gcacagtgtc
      361 catggagctg agcagcctga gatccgaaga cacagccgta tactactgtg cgagaggggg
      421 ggacatagaa tattgtactg gtagtggttg tggggagctt gactcctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002121             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21089:11379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002121
VERSION     KCXD01002121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21089:11379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60603.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       440..447
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          124 a          143 c          142 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagcc acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagttaa gaagcctggg gcctcagtga
      181 tggtctcctg ccaggtttcc ggatacaccg tcaccgaaat atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttgc tcctgaaaaa aatgagttaa
      301 tacacgcaga caagttccag gacagagtca gcatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtggc ctgacatttg aggacacggc cgtgtattac tgtgcgaccc
      421 acggaggtta tagcgacatc tggaactccc tatataacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002122             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8701:19208
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002122
VERSION     KCXD01002122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8701:19208"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60604.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       425..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          118 a          144 c          133 g           99 t
ORIGIN      
        1 acatggggaa acatcacaca acaaccacat ccctccccta cagaagcccc agagcgcagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttagt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg caatctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcagcgattt atccatacac tggatacgac
      241 aggcccctgg aaaagggctt cagtggatgg gaagtgttga tcctgctttt ggtgaaatga
      301 taaacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtct tcagacacag
      361 ccttcatgga attgagcagc ctgaaatctg acgacacggc cgtgtatttc tgtgcgagtg
      421 gccctagcgg cacctggatc gactggtcct tcgatgtctg gggccctggc accccaatca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01002123             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21954:5462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002123
VERSION     KCXD01002123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21954:5462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    72..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        72..438
     V_segment       72..365
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60605.1"
                     /translation="CARVGEATGGAEDFDFW"
     D_segment       377..383
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           95 a           99 c          135 g          111 t
ORIGIN      
        1 acatgggact caccatgaag tttgggctga gctgggtttt ccttgttgct attttaagag
       61 gtgtccagtg tgaggtacaa ctggtggagt ctggaggagg cttggttcag cctggggggt
      121 ccctgagact ctcctgtgca gcctccggat tcaccttcag tagctttggc atgcactggg
      181 tccgccaggc tccagggaag ggactggagt gggtggcact gatatcgtat gatggaaata
      241 agaaatacta cgcagactct gtgaaggacc gattcaccct ctccagagac aattccgaga
      301 acatcctata tcttcaaatg aacaacctga aattggagga cacggccgtg tatttttgtg
      361 cgagagttgg agaggctact ggtggtgcgg aggactttga cttctggggc cagggagtcc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002124             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20923:9038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002124
VERSION     KCXD01002124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20923:9038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60606.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           92 a          137 c          130 g          108 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gagcatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggccctgtc ccaggtgctt ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag caatagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caaccccgcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002125             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20075:8872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002125
VERSION     KCXD01002125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20075:8872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60607.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          107 a          122 c          159 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggtact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gctattgcaa
      301 gtggtggaga aaacacatac tatgcagact ccgtgaaggg ccgattcacc gtctccagag
      361 acaactcaaa gagcacagtc tccctgcaaa tgaacagtct tagaacggag gacacggccg
      421 tgtattactg tgcgaatgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002126             354 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7962:7164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002126
VERSION     KCXD01002126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 354)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 354)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7962:7164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..352
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..352
     V_segment       6..282
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <274..>321
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60608.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       285..300
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..352
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        353..>354
                     /gene="IGHG"
BASE COUNT           73 a           95 c          107 g           79 t
ORIGIN      
        1 acatgggagt ctgggggcgg cttggcaaag cctgggggat ccctgagact ctcctgtgca
       61 gcctctggat tcaccttcag tacctatgct atgcactggg tccgccaggc tccagggaag
      121 gggctggagt gggtctcagc cattagtgtt ggtggtagta catactacgc agactccgtg
      181 aggggccgat tcaccatctc cagagacaac tcagagagca cgctctccct gcaaatgaac
      241 agcctgagta ctgaggacac ggccgtgtat tactgtgcca aaggggatac agctacagtt
      301 tattacggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002127             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16233:18786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002127
VERSION     KCXD01002127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16233:18786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60609.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          112 a          144 c          134 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaactgttga tcctctatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggccg tgtattactg tgcgactggc cctagcggca
      421 cctggaacgc ctggtacctc gatatctggg gccctggcac cccaatcatc atctcctcag
      481 cc
//
LOCUS       KCXD01002128             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13110:20763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002128
VERSION     KCXD01002128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13110:20763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60610.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          112 c          153 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatggca
      241 ttcactgggt tcgccagact ccggggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaactaa gacatactac gcagactctg tgagggaccg attcaccatc tccagagaca
      361 attccaaaaa catggtgtat tttcaaatga acaacctgaa attggaggac acggccgtat
      421 attactgtgt gcgagatgtc aggggaacgg ggtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002129             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24594:16450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002129
VERSION     KCXD01002129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24594:16450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60611.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       268..273
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           76 a           78 c           93 g           74 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
       61 ggcattcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      121 tatgatgaaa ctaagacata ctacgcagac tctgtgaagg accgattcac catctccaga
      181 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtgtattact gtgcgagaga tgtcagggga acggggtttg acttctgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002130             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16309:3852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002130
VERSION     KCXD01002130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16309:3852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..483
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60612.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       400..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..483
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           99 a          135 c          138 g          113 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcga gaacatgaag tatctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ttgcaggagt
      121 cgggcccagg actgatgaag ccttcagaga ccctgtccct cagctgcgct gtctctggtg
      181 gctccataag tggtaactgg tggagctgta tccgccagcc cccagggaag ggactggact
      241 ggattggacg tatctctggt actagtgggg acaccaatta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttctc cctgaagctg aactctgtga
      361 ccgccgcgga cgcggccgtg tattattgtg caagagcgga ttacgaggat gattacggtt
      421 atcatttagg atacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01002131             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25061:10716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002131
VERSION     KCXD01002131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25061:10716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60613.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       281..286
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           83 a           83 c           93 g           84 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtaact ttggcataca ctgggtccgc caggctcccg ggaagggtct
      121 ggagtgggta gcagttatct cccatgatga aaataatata tattacgcag actctgtgaa
      181 ggaccgattc accatctcca gagacaattc caagaacaac gtatatcttc aaatgaacaa
      241 cctgaaattg gaggacacgg ccgtgtttta ctgtgtgaga gatacattcg gttcaggatt
      301 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002132             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19173:15806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002132
VERSION     KCXD01002132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19173:15806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60614.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          121 c          149 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cactcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaat aaagaaattc cacgcagact ctgtgaagga ccgaatcacc atctccagag
      361 acaattccaa gaacacgctt tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002133             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12356:2899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002133
VERSION     KCXD01002133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12356:2899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..506
     V_segment       128..421
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60615.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       425..444
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          110 a          142 c          147 g          109 t
ORIGIN      
        1 acatggggga gcatcacata acaaccacgt ccctcctcta aagaagcccc tgggaacaca
       61 gctcatcacc atggacttga cctggaggct cctctttgtg gtggcagcag ctacaggtgc
      121 ccagtctcag gtccagctgg tgcagtccgg ggctgagatg gagaagcctg gggcctcagt
      181 gaagctctcc tgtaaggctt ctggatacac cttcagcatc tatgtcatca gttgggtgcg
      241 acaggcccct ggacaagggc ttgagtggat gggaggcatc ttccctcttg ttggtacaac
      301 aaactacgca cagaagttcc agggcagagt cacgattacc gcggacacgt ccacaagcac
      361 agcctacatg gacctgagca gcctgggatc tggggacacg gccgtgtatt attgtgcgag
      421 aggttactgt actggtagtg gttgtaacct tacattcaac cggctcgatg tctggggccc
      481 gggagtcccg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002134             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10550:10320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002134
VERSION     KCXD01002134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10550:10320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60616.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          140 c          134 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacagg agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggcg gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggttaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaat ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 cttggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01002135             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:24323:7984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002135
VERSION     KCXD01002135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:24323:7984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..447
     V_segment       84..383
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60617.1"
                     /translation="CARRIRGGWPYFDFW"
     D_segment       393..397
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           96 a          138 c          115 g          100 t
ORIGIN      
        1 acatgggggg actcctgtgc cccaccatgg acacgctttg ctccacgctc ctgctgctga
       61 ccgtcccgtc ctgggtcttg tcccaggtga ccttgaagga gtctggtcct gcgctggtga
      121 aacccacaca gaccctcacg ctgacctgcg ccgtctctgg gttctcactc aacaatattg
      181 gtatgggggt gggctggatc cgtcagccct caggaaagac cctggagtgg cttgcacaca
      241 tttactggga tgataacaag ctctacagca catctctaaa gaacagactc accatctcca
      301 gggacacctc caaaaacctg gtacttctga caatgaccaa catggaccct gcggacacag
      361 ccacatattt ctgtgcacga agaattaggg gcggttggcc gtattttgac ttctggggcc
      421 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002136             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16341:5301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002136
VERSION     KCXD01002136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16341:5301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60618.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           98 a          134 c          136 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ttggagctgg attcgccagc ccccagggaa gggactggaa
      241 tggattgggt atattagtgc cagtactggg agcaccgact acaacccctc cttcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaggct gacgtctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagaga aatactatag tggtagttat
      421 aaacacaact ggttcgatgt ctggggtccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002137             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12242:13929
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002137
VERSION     KCXD01002137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12242:13929"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60619.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          119 c          145 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgc ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagagctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccactac agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002138             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12199:18789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002138
VERSION     KCXD01002138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12199:18789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60620.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          111 c          154 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccgggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tatactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002139             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12974:5148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002139
VERSION     KCXD01002139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12974:5148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..479
     V_segment       110..403
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60621.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       404..413
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          110 a          132 c          132 g          107 t
ORIGIN      
        1 acatggggac atccctcctc taaagaagcc cctgggagca cagctcatca ccatggactg
       61 gacctggagg ctcctctttg tggtggcagc agctacaggt gtccagtccc aggtccagct
      121 ggtgcagtcc ggggctgagg tgaagaagcc tggggcctca gtgaaggttt cctgcaaggc
      181 ttctggattc accttcgaca actatggtat caactgggtg cgacaggccc ctggacaggg
      241 gcttgagtgg atgggagtaa ccatccccct tgttggtata atcaactaca gagacaacgt
      301 ccaggacaga gtcaccattt cctcggacac gtccacaaac acagcctaca tggagataaa
      361 cagcctgaga tctgacgaca cggccatcta ttactgtgcg agagaatatt gtacttctac
      421 tgattgcgcc ggattttttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01002140             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19439:12752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002140
VERSION     KCXD01002140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19439:12752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60622.1"
                     /translation="CARVTGIDGTTVEYFDFW"
     D_segment       444..459
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..513
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          118 a          118 c          158 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ctccttgttg
      121 ctattttaag aggtgtccaa tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga gtctcctgtg cggcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcat
      301 ctgatggaag taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatgttcaga tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagta accggtatag atggaactac cgttgaatac ttcgatttct
      481 ggggccaggg cgccctggtc accgtctcgt cagcc
//
LOCUS       KCXD01002141             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19365:6441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002141
VERSION     KCXD01002141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19365:6441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60623.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       409..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           90 a          148 c          126 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtaca agaacatgca gtttctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gtcgtaactg gtggagttgg gtccgccagc ccccaggcaa gggactggag
      241 tggattggac gtatctctgg tagtcttgga agcaccagtt acaatccctc cctcgagagt
      301 cgagtcacca tttcaagaga cacgtccagg aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt gtatttctgt gcgagacatt cagaccccgc aactactagc
      421 tggtacttcg atctctgggg ccctggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01002142             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:18055:19856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002142
VERSION     KCXD01002142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:18055:19856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..428
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60624.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       376..382
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       387..428
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT           91 a           99 c          132 g          108 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc agcctggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg gcatgcactg
      181 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt ctgctggaag
      241 taagaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag acgactccag
      301 gaacatgcta tatcttcaac tgaacaacct gaaattggag gacacggccg tgtattactg
      361 tgcgagagat gtgtatggct gggggcttga ctactggggc cagggagtcc tagtcaccgt
      421 ctcctcagcc
//
LOCUS       KCXD01002143             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23255:9410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002143
VERSION     KCXD01002143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23255:9410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60625.1"
                     /translation="CAGGSRRQPENW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           83 a          132 c          139 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctatgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atcggtggta ctagtgggag tacctactac aatccctccc tcgagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa tctcttctcc ctgaagatga gttctttaac
      361 cgccgcggac acggccatgt atttctgtgc gggcggaagt cgacggcagc cggagaactg
      421 gggccaggga gtcctggtca ccgtctcttc agcc
//
LOCUS       KCXD01002144             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:17674:11163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002144
VERSION     KCXD01002144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:17674:11163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..467
     V_segment       98..389
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60626.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       398..409
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          136 c          134 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agaacatcct gtgcaagaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcagctc ccagatgggt cctgtcccag ctgcagctgc aggagtcggg
      121 cccaggactg gtgaagcctt tggagaccct gtccctcacc tgcgctgtct ctggtggctc
      181 catcagcagt aactactgga gctggatccg ccagtcccca ggaaagggac tggagtggat
      241 tggacgtatt tctgggagtg gtgggagcac cgtctacaac ccctccctca agagtcgagt
      301 caccttttca acagacacgt ccaagaacga gatctccctg aaagtgacct ctgtgaccgc
      361 cgcggacacg gccgtatatt attgtgcgac agccggatat agcagcagcg aaagcttcta
      421 cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002145             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12314:14288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002145
VERSION     KCXD01002145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12314:14288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60627.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          146 c          133 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaagtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca ggatttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctgtatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacaaccta cttggaactg
      361 agcggcctga cttctgagga cacggccgtg tattactgtg cgactggccc taccggcacc
      421 tggaacgcct ggtacctcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002146             278 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19095:6817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002146
VERSION     KCXD01002146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 278)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 278)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19095:6817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..276
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..276
     V_segment       8..215
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <207..>245
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60628.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       219..230
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       235..276
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        277..>278
                     /gene="IGHG"
BASE COUNT           71 a           67 c           80 g           60 t
ORIGIN      
        1 acatgggcat taactatggc atgcactggg tccgccaggc tccagggaag ggtctggagt
       61 gggtggcagt tatgtcgcat gatggaacta agaaattcta cgcagactct gtgaaggacc
      121 gattcaccat ctccagggac aattccaaga acatggtata tcttcaaatg aacaacctga
      181 gattggagga cgcggccgtg tattactgtg cgagaggaga ctacggtaac agccttgact
      241 actggggcca gggagtccgt ctcaccgtct cctcagcc
//
LOCUS       KCXD01002147             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17761:17425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002147
VERSION     KCXD01002147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17761:17425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..494
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60629.1"
                     /translation="CVRRPFGSDAFDFW"
     D_segment       440..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..494
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          112 c          148 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaaatttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtcact atggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgcatgatga
      301 aaataagaaa tactacgtag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgcaattg gaggacacgg ccgtgtatta
      421 ttgtgtgaga cgaccgttcg gtagtgatgc ttttgatttc tggggccaag ggctcagggt
      481 caccgtctct tcagcc
//
LOCUS       KCXD01002148             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23391:15617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002148
VERSION     KCXD01002148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23391:15617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..398
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60630.1"
                     /translation="CARDTTFTGRYDYW"
     D_segment       401..407
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           96 a          133 c          134 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg agtggtgaag ccttcgggga ccctgtccct cacctgcgct gtctctggtg
      181 gctctatcag catcagttac aggtggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg atacatctat ggtagtagtg cgagcacaaa ctacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccttgaag ctggactctg
      361 tgacggccgc ggacacggcc gtgtattact gtgcgagaga tactaccttt accggcaggt
      421 atgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002149             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:26073:15915
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002149
VERSION     KCXD01002149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:26073:15915"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60631.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       436..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          107 a          118 c          151 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttccta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggagtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtctgta atttcgtctg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 actccaagaa cacactatat tttcaaatga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgt gagagatgcc ttcgggggcg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002150             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27654:13154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002150
VERSION     KCXD01002150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27654:13154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60632.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          140 c          132 g           95 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggagaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggaactga gcagtctgag atctgaggac acggccgtat attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01002151             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15153:6315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002151
VERSION     KCXD01002151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15153:6315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..457
     V_segment       100..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60633.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       399..408
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           83 a          139 c          135 g          102 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcagagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagtccc cagggaaggg gctggagtgg
      241 attgggtttt tcggtggtag tggtgggagc acctactaca aatcctccct ccagagtcgc
      301 gtcaccattt caaccgacac gtccaagaac cagttctccc taatactgac ctctgtgacc
      361 gccgcggaca cggccctcta ttactgtgcg agggggaata tagcagcgac tggcattgac
      421 tactggggcc agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002152             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8778:5510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002152
VERSION     KCXD01002152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8778:5510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60634.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          121 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgaaac taagcaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002153             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15010:7856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002153
VERSION     KCXD01002153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15010:7856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    132..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        132..486
     V_segment       132..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60635.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       436..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          108 a          120 c          144 g          116 t
ORIGIN      
        1 acatgggggg agcccagccc tggaagtcca cagtgttcca ttcggtgatc agcacagaac
       61 acagaggact caccatgaag tttgggctga actgggtttt ccttgttgct attttaagag
      121 gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag ccgggggggt
      181 ccctgagact ctcctgtgca gcctctggat tcaccttcag tacttttggc atccactggg
      241 tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtct gatggaaata
      301 acctatacta cgcagactct ctgaaggacc gattcaccat ctccagagac aattccaaga
      361 acatggtgta tcttcaaatg aacaacctga aattggagga cacggccgtc tattactgtg
      421 cgagagattc atatggcagc ggctccgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01002154             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18913:14796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002154
VERSION     KCXD01002154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18913:14796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60636.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       413..424
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          107 a          137 c          137 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggaagaa ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcctgaa tatggtgaaa tgatgttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag
      361 cctgagatct gaggacacgg ccgtctatta ctgtgcgatt ggccctagtg gcagctggaa
      421 cgactggtcc ttcgacattt ggggacctgg caccccaatc accgtctcct cagcc
//
LOCUS       KCXD01002155             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:10477:12734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002155
VERSION     KCXD01002155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:10477:12734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60637.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          103 a          125 c          155 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact acttcatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta ccagtggtgg
      301 ggataacaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaccaca ctgtatcttc acatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcaaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002156             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7944:18162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002156
VERSION     KCXD01002156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7944:18162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60638.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       268..273
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           80 a           77 c           92 g           72 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
       61 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      121 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga
      181 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtatattact gtgcgagaga tgtcagggga acggggtttg acttctgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002157             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:12567:14180
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002157
VERSION     KCXD01002157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:12567:14180"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..517
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60639.1"
                     /translation="CARERFGGTGVIIYSWVDFW"
     D_segment       451..464
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..517
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          107 a          127 c          163 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtatttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttcttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca acctccggat tcatcttcag tgacttctac
      241 atggactggg tccgccaggc tccagggaag gggctggagt gggtctcacg tattaatcat
      301 gatggtggta gcacatggta cgcagactcc gtgaggggca gattcaccat ctccagagac
      361 aacgccaaga acacactgta tcttcaaata gacagcctga gacctgagga cacagccgtg
      421 tatttctgtg cgagagagcg gtttggggga actggggtga ttatctacag ctgggtcgat
      481 ttctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002158             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24499:12337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002158
VERSION     KCXD01002158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24499:12337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60640.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgtctatg
      241 gcttccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002159             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14116:19738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002159
VERSION     KCXD01002159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14116:19738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60641.1"
                     /translation="CAIGPSGNWNGWSFDVW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          104 a          139 c          139 g           96 t
ORIGIN      
        1 acatggggat ccaacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaactgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatggtgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctatagac acagcctata tggagttgag
      361 cagcctgaga tctgaggaca cggccgtgta ttactgcgcg attggcccta gcggcaactg
      421 gaacggctgg tccttcgatg tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002160             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22506:16187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002160
VERSION     KCXD01002160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22506:16187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60642.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          115 a          146 c          127 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgacgtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg taaagcagac
      301 tacacacaga agttccaaaa cagagtcacc atcaccgcgg acatgtcgac agagacagcc
      361 tacatggagc tgagcagcct cagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attattttga cttctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002161             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4870:10628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002161
VERSION     KCXD01002161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4870:10628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60643.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       411..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          105 a          140 c          145 g          104 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaagtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccag aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattactg tgcgagaggc tactgcactg
      421 gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002162             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:28647:10778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002162
VERSION     KCXD01002162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:28647:10778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60644.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          115 c          150 g          124 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgcccag tgtgaggtac aattggtgga gtctggagga ggtttgggtc
      181 agcctggggg gtccctgaga ctctcctgtg aaacttctgg attcaccttc agtaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 atgatgtaag taagacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattctaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002163             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24328:18705
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002163
VERSION     KCXD01002163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24328:18705"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..513
     V_segment       141..433
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60645.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       448..462
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          115 a          124 c          147 g          129 t
ORIGIN      
        1 acatgggggg ggagaggaga cccagccttg ggatttccag ctgtctccac ttggtgatca
       61 gcactgaaca caggagactc gccatggagt ttgtactgag ctgggttttc cttgttgcta
      121 tattaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggcgggtc cctgagactc tcctgtgcag cctctggatt caccttcagt gactatgccc
      241 tgagctgggt ccgccaggct tctgggaaag gactggagtg gattggctat attagaagcc
      301 aatataacaa tttcgcgaca gaatacgccc catcggtgaa aggcagattc accatctcca
      361 gagatgattc aaagaacacg ctatttctgc aaatgagtag cctgaaaacc gaggacacgg
      421 ccgtgtatta ctgcaccacc cattttggtg gtaattatta cttggactac tttgtctact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002164             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17943:14473
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002164
VERSION     KCXD01002164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17943:14473"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60646.1"
                     /translation="CARSWGGLLSPEYFDFW"
     D_segment       437..442
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..509
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          111 a          120 c          157 g          123 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tgggattccc aggtgtttgc attcagagat
       61 caggactgaa cacacaggac tcaccatgga gtttatgctg agctgggttt tccttgttgc
      121 tatattaaaa ggtgtccagt gtgtggagca actggtggag tctgggggag gcttggtaca
      181 gcctggggcg tccctgagac tctcctgtgc agcctctgac ttcaccttca gtagctatga
      241 catgcactgg gttcgccagg ctccagggaa gggtctggag tgggtatcag gtattagcat
      301 tggcggcggc ggcacatact acccagactc tgtgaagggt cgattcacca tctctagaga
      361 caatgacaac aaagacttgt atcttcaaat gaacagtctg agagctgagg acacggcagt
      421 gtatttttgt gcaagaagct gggggggctt actaagcccg gaatacttcg atttctgggg
      481 ccagggcgcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002165             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17529:9641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002165
VERSION     KCXD01002165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17529:9641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60647.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       438..443
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          112 c          149 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gtttctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtatt tttggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggctgttata tcgaatgatg
      301 gaagtaaaaa atactactca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccgaggccaa tgtatatctt caaatgaata acctgaagtt agaggacacg gccgtatatt
      421 actgtgtgag agatgcgtat ggttccggct tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002166             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20814:9474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002166
VERSION     KCXD01002166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20814:9474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60648.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          121 c          147 g          128 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgtttctat
      121 attaaaaggt gtccagtgtg tggagcttct ggtggagtct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagtg gctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctagaatgg gtatcaggta ttaacattgg
      301 cggtgaccca tactacccag actctgtgaa gggtcgattc accatctcca gagacaacgc
      361 cgagaactcc ttgttccttc aaatgaacaa cctgagacct gaggacactg ctgtgtatta
      421 ttgtgtgagg gggatggata actaccactt cagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002167             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16039:5493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002167
VERSION     KCXD01002167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16039:5493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60649.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          117 a          140 c          150 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtaa
      181 aggtctcctg ccaggtttcc ggagacacct tcagtgaaat gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgttgc tcctggaaat ggggaaataa
      301 tacacgcaga taacttccag ggcagagtca ccatgaccga ggacacgtct atagacacag
      361 cctacatgga gctgagtagc ctgagatctg aggacacggc cgtatattac tgtgcgagcg
      421 ggacatttgg gaccagcgtc tggtccagcc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt cagcgtctcc tcagcc
//
LOCUS       KCXD01002168             336 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15798:21449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002168
VERSION     KCXD01002168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 336)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 336)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15798:21449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..334
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..334
     V_segment       7..273
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <265..>303
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60650.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       277..289
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       293..334
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        335..>336
                     /gene="IGHG"
BASE COUNT           82 a           81 c           91 g           82 t
ORIGIN      
        1 acatggggct tggttcagcc gggggggtcc ctgaggctct cctgtgcagc ctctggattc
       61 accttcagta attatggctt ccactgggtc cgccaggctc cagtgaaggg gctggagtgg
      121 gttgcagtta tatcgtatga tgaaaatgtg aaattctacg cagactctgt aaaggaccga
      181 ttcaccatct ccagagacaa ttccaagaac atgctatatc ttcaaatgaa caacctgaaa
      241 ttggaggaca cggccgtgta ttactgtacg agaggggaat acagtaactc tattgactac
      301 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002169             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17367:14088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002169
VERSION     KCXD01002169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17367:14088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60651.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       440..444
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          118 c          153 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 tctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg agtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgtc tgtaatttcg
      301 tctgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaactcca agaacatact atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgtgagaga tgccttcggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01002170             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15619:4997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002170
VERSION     KCXD01002170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15619:4997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60652.1"
                     /translation="CARGLPTVFGVVITDVW"
     D_segment       415..426
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..467
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          136 c          136 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagacg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcactg tctctggtga
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggcat atcagtgtta gtcttgggaa gaccgactac aacccgtccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaaggtga attctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagaggactt cctacagttt ttggagtggt
      421 tattacggat gtctggggcc cgggagtcct ggtcatcgtc tcctcagcc
//
LOCUS       KCXD01002171             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15182:16737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002171
VERSION     KCXD01002171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15182:16737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..264
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <256..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60653.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       268..275
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..325
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           76 a           82 c           89 g           80 t
ORIGIN      
        1 acatgggagc ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt
       61 aactatggct tgcactgggt ccgccaggct ccagggaagg ggctggattg gctggcagtt
      121 atgtcgtttg atgaaaatgt gaaattctac gcagactctg tgagggaccg attcaccatc
      181 tccagagaca attccaagaa catgctttat cttcaaatga acaacctgaa attggaggac
      241 acggcccttt attactgtgc gagaggggaa tacagcaact ctattgactt ctggggccag
      301 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002172             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7412:18683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002172
VERSION     KCXD01002172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7412:18683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60654.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          140 c          134 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002173             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19132:9785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002173
VERSION     KCXD01002173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19132:9785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60655.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       403..414
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          138 c          136 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaacta ctggagctgg atccgccagt ccccaggaaa gggactggag
      241 tggattggac gtatttctgg gagtggtggg agcaccgtct acaacccctc cctcaagagt
      301 cgagtcacct tttcaacaga cacgtccaag aacgagatct ccctgaaagt gacctctgtg
      361 accgccgcgg acacggccgt atattattgt gcgacagccg gatatagcag cagcgaaagc
      421 ttctacggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002174             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:8769:15153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002174
VERSION     KCXD01002174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:8769:15153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60656.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          138 c          134 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgacgc cctcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaac agtggttatg gctggagctg ggtccgccag cccccaggga aggggctgga
      241 gtggattggg tgtctctatg atagtagtgg gaacacgtac tacaacccct ccctcaagag
      301 tcgcgtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaacc tgaggtctat
      361 gaccgccgcg gacacggccg tctattactg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002175             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18706:15409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002175
VERSION     KCXD01002175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18706:15409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60657.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccagtga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002176             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16012:7596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002176
VERSION     KCXD01002176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16012:7596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60658.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          116 c          150 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcgggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat cgtatgatga
      301 gactaagaaa tattacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtgtatta
      421 ctgtgcgaga gattcttacg gtcgaggctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002177             339 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:23505:6184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002177
VERSION     KCXD01002177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 339)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 339)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:23505:6184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..337
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..337
     V_segment       7..276
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <268..>306
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60659.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       280..286
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       295..337
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        338..>339
                     /gene="IGHG"
BASE COUNT           79 a           83 c           94 g           83 t
ORIGIN      
        1 acatggggag gcttggttca acctgggggg tccctgagac tctcctgtgc agcctctgga
       61 ttcaccttca gtaattttgg catacactgg gtccgccagg ctccagggaa ggggctggag
      121 tgggtggcag ttatttcgtc tgatggaagt cacaaatact acgccaactc tgtgaagagc
      181 cgattcgcca tctccagaga caattccaag aacatactat atcttcaaat gaacaacttg
      241 aaattggagg acacggccgt ctattactgt gcgagagatg atattgggac cggttttgac
      301 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002178             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8868:14367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002178
VERSION     KCXD01002178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8868:14367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60660.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          117 c          156 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gacctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagccgctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggca gttaactcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtca tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 gcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002179             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10521:8988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002179
VERSION     KCXD01002179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10521:8988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60661.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          112 c          156 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgcacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01002180             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19500:4846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002180
VERSION     KCXD01002180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19500:4846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60662.1"
                     /translation="CATDARGSGLDSW"
     D_segment       437..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          112 c          159 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca ccttcagtag ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtctgat
      301 gggaataaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 ttcaagaaca tgctgtatct tcaaatgaac agcctgaaaa tggaagacac ggccgtgtgg
      421 tactgtgcga cagatgcgag gggttccggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002181             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24133:14502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002181
VERSION     KCXD01002181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24133:14502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60663.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          114 c          156 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttcg gaacctatgg
      241 catgcactgg gtccgccagg ctccagggat gggcctggag tgggtgacgg ttatatcgaa
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcagca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacgtg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cgtttggtag cgggcttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002182             314 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17277:19987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002182
VERSION     KCXD01002182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 314)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 314)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17277:19987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..312
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..312
     V_segment       8..250
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <243..>281
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60664.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       251..257
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       273..312
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        313..>314
                     /gene="IGHG"
BASE COUNT           77 a           76 c           86 g           75 t
ORIGIN      
        1 acatgggcct gagactctcc tgtacagcct ctggattcac cttcagtagt tatggcttgc
       61 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtctgatg
      121 aaagtaggaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      181 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      241 actgtgcgag ggatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      301 ccgtctcctc agcc
//
LOCUS       KCXD01002183             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8355:13683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002183
VERSION     KCXD01002183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8355:13683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..485
     V_segment       113..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60665.1"
                     /translation="CARGGWWDDYPPSDAFDFW"
     D_segment       418..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           92 a          140 c          142 g          113 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcacggac atcctgtgca agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca
      121 gctgcaggag tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc
      181 tgtctctggt tactccgtca gcagtgacta ctggagttgg atccgccagc ccccagggaa
      241 gggactggag tggattgggt atatctctgg tagtagtggc agcacctcct acaacccctc
      301 cttcaagagt cgagtcacca tttcaacaga cacgtccaag agccacttct ccctgaagct
      361 gacctctgtg accgccgcag acacggccgt gtattactgt gcgagggggg gttggtggga
      421 tgattatccc ccttcggatg cttttgattt ctggggccaa gggctcaggg tcaccgtctc
      481 ttcagcc
//
LOCUS       KCXD01002184             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18998:3676
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002184
VERSION     KCXD01002184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18998:3676"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..494
     V_segment       131..424
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60666.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       434..440
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          120 c          150 g          119 t
ORIGIN      
        1 acatgggggg agcccagccc cagaattccc aggtgtttct gttcggcgat cagcacaaaa
       61 cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc ttttgaaagg
      121 tgtccaatgt gaggtgaaac tggtggagtc tgggggcggc ttggcaaagc ctggggggtc
      181 cctgagactc tcctgcgcag cctctggatt caggttcaat tattactaca tgagctgggt
      241 ccgccaggct ccagggaagg ggctggagtg gatctcaggt gttaatactg gtggggaaag
      301 cccatactct gcagactccg tgaagggcag attcaccatc tccagagaga acgccaagaa
      361 tacactatat cttcaaatgg acagcctgag aactgaggac acggctgtct atttctgtgt
      421 gagagatcgg cgtgtacagt cgttatcctg gttcgatgtc tggggcccgg gagccctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002185             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9728:16411
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002185
VERSION     KCXD01002185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9728:16411"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60667.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       422..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          113 a          139 c          138 g          101 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggttca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acgcagaaaa gttccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagcctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcaa ttggcttttt tggtacttcg atttttgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002186             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:25407:10057
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002186
VERSION     KCXD01002186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:25407:10057"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60668.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       442..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          106 a          113 c          152 g          124 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tcctgtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 cgggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat gtcgtctgat
      301 ggaagtaaca tatactacgc agcctctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgttatatct tcaaatgaac aacctgaaat ttgaggacac ggccgtctat
      421 tactgtgcga gagatgtgta cggtagtggg ttagactact ggggcctggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002187             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21130:14968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002187
VERSION     KCXD01002187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21130:14968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60669.1"
                     /translation="CARGTGAILVYFDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          123 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtcctgt gtgagataaa actggtggag tctgggggcg acttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcctca ggcactacta
      241 tctgacctgg gtccgccagg gtccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtgggagt agcacatact atgcagactc cgtgaaggac agattcacca tctccagaga
      361 caacgccaag aacacactgt atcttcaaat ggacaacctg agagctgagg acacggctgt
      421 ctattactgt gcgaggggga ctggggcgat tcttgtgtac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002188             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22652:8801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002188
VERSION     KCXD01002188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22652:8801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60670.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          122 c          146 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgaactgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg agttcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002189             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6628:3901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002189
VERSION     KCXD01002189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6628:3901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60671.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          138 c          130 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggcgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccgtca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaggagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002190             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13031:16350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002190
VERSION     KCXD01002190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13031:16350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60672.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       440..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          111 a          121 c          165 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggtct gacctgggtt ttccttgttg
      121 gtcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggctc
      181 agcctggggg gtccctgaga ctctcctgtg cagcgtctgg gttcaccttc agtagctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gccatatcgt
      301 ttgatggaag taaggagaac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtactactg ttcgagggag tggatacagt gggcgcagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002191             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17217:14912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002191
VERSION     KCXD01002191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17217:14912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60673.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           88 a          144 c          131 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctctccctc acctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgcagctga attatgtaac
      361 ccccgcggac acggccgtgt attactgtgc cagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccggggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002192             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13045:10946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002192
VERSION     KCXD01002192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13045:10946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60674.1"
                     /translation="CARVDYSANYYFHRFDVW"
     D_segment       402..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           98 a          141 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag ttacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cctcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgaaac ttcagcagtg
      121 gggcgaagga ctggtgaagc cttcggagac cctgtccctc atctgcgctg tctctggtgg
      181 ctccatcagc ggtgactact actggagctg gatccgccag ccccccggga aggggctgga
      241 gtggattgga tatatctatg ctgatagtgc gaccaccaag tacaacccct ccctcaacaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggcca tatattactg tgcgagagtg gactatagtg ctaattatta
      421 cttccaccgc ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002193             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21227:5086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002193
VERSION     KCXD01002193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21227:5086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60675.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       448..453
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          118 c          163 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggggg cggcttggca
      181 cagcctgggg ggtccctgag actctcctgt tcagcctctg gattcacctt cagtaggcac
      241 tggatgaact gggtccgcca ggctccagga aaggggctag agtgggtctc cggtattaat
      301 agtggtgggg acactacata ctacgcagac tccgtgaagg gccgattcac catgtccaga
      361 gacaattcaa agaacactct ctccctgcaa atgaacagcc tgagagcgga ggacacggcc
      421 gtgtattatt gtgtgcaagg ggaaattttt ggagtgggtt tggatttctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002194             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6932:9320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002194
VERSION     KCXD01002194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6932:9320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60676.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          115 a          141 c          129 g           90 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggtctccg tgaaaatctc
      181 ctgccaggct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatgggaaag tagactacac
      301 acagaagttc caagacagag tcaccatcac cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccacttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgactact ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01002195             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19672:14732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002195
VERSION     KCXD01002195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19672:14732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60677.1"
                     /translation="CAREGISASGVDYW"
     D_segment       400..406
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          137 c          144 g          100 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc aacttcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttttcggtg gtcgcaatgg gaacacctac taccacccct ccctcaagag
      301 tcgagtcacc atttcaccag acacgtccaa agaccagttc tccctgaggc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagggag gggatatcag cgtcgggggt
      421 cgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002196             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16394:6220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002196
VERSION     KCXD01002196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16394:6220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60678.1"
                     /translation="CARGDTGFPPNYFDYW"
     D_segment       413..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          103 a          134 c          138 g          104 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg attcaccttc ggcagtaatg ctatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ctgatcatcc cttttcttgg tgttacacac tacgcagaga
      301 acttacaggg cagagtcgcg atcaccgcgg acacgtctac aagcacagcc tccatggaac
      361 tgagcagcct gagatctgaa gacacggccg tgtattactg tgcgagaggt gatactggtt
      421 ttcctcccaa ttactttgac tactgggacc ggggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002197             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19219:15519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002197
VERSION     KCXD01002197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19219:15519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..448
     V_segment       94..390
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60679.1"
                     /translation="CARWSAANFDYW"
     D_segment       395..401
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           88 a          135 c          132 g           95 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgggc aagaacatga agcatctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 aacagtggtt atggctggag ctgggtccgc cagcccccag ggaagggtcc ggagtggatt
      241 gggtgtctct atgatagtag tggcaacacg tactacaacc cctccctcaa gagtcgcgtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga acctgaggtc tatgaccgcc
      361 gcggacacgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002198             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19076:17046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002198
VERSION     KCXD01002198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19076:17046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..487
     V_segment       136..428
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60680.1"
                     /translation="FSRDRQKEIDFR"
     D_segment       429..433
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          109 a          126 c          145 g          109 t
ORIGIN      
        1 acatgggggc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa agtgtgaggt gcaactggtg gagtctgggg gagacttggt ccagcctgga
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtcgttc cgacatgacc
      241 tgggtccgcc aggctccggg aaaggggctg gagtgggtct catatattac ttacacggaa
      301 aaaaccataa actacgctga ctccgtgaag ggccgattca ccatctccag agacaacgcc
      361 aagaagtcgc tgtctctgca aatgagcagc ctcagagccg aggacgcggc cgtgtgtttc
      421 tttagtagag atcgtcaaaa agagattgac ttccggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01002199             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5182:9682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002199
VERSION     KCXD01002199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5182:9682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..363
     V_segment       8..287
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60681.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       288..296
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       320..363
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           73 a          105 c          102 g           85 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcacctgcg
       61 ctgtctctgg tggctccatc agcagtaact cctggagctg gatccgccag tccccaggga
      121 agggactgga gtggatcggt tatgtctatg gtgatagtgg gaacaccgaa tacaacccct
      181 ccctcaagag tcgagtcacc atttcaagag actcgtccaa gaatcagttt tccctgaagc
      241 tgagttctgt gaccgccgcg gacaccgccg tgtatcactg tgcgagatac agttacggtt
      301 ccaactactt ctttgggttc tttgactatt ggggccaggg agtcctggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01002200             356 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19139:6200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002200
VERSION     KCXD01002200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 356)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 356)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19139:6200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..354
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..354
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>323
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60682.1"
                     /translation="CARDKGYSAVRRFDVW"
     D_segment       294..300
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..354
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        355..>356
                     /gene="IGHG"
BASE COUNT           70 a          109 c          102 g           75 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg
       61 tctctggtgc ctccatcagc agtaactcct ggaactggat ccgccagccc ccaggggggg
      121 gactggagtg gattggacgt atctctagtc ttagtgggag caccaactac aacccctccc
      181 tcacaagtcg agtcaccatt tcaacagaca cgtccaagat ccagatctcc ctgaggctaa
      241 gttctgtgac cgccgcggac acggccgtgt attactgtgc gagagataag ggttacagtg
      301 cagttcgacg gttcgatgtc tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002201             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22009:16700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002201
VERSION     KCXD01002201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22009:16700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60683.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       417..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          141 c          131 g          101 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 tcctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaagtaaa gtggcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaaggcctt gagtggatgg gaggttttgg tcctgtgtat ggtgaaataa
      301 tacacacaga gaagttccag ggcagagtca ctatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtctattac tgtgcggcag
      421 ctgatagtgg ttacccattt tactacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002202             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14558:5334
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002202
VERSION     KCXD01002202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14558:5334"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60684.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          117 c          155 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cggccggggg ggtccctgag actctcctgt gcagtctctg gattcacctt caatacctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 ggtgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtacgagaga cgcatttggc agcggctgtg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002203             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:26624:7244
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002203
VERSION     KCXD01002203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:26624:7244"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60685.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          134 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcatcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aaggctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtcttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002204             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13078:7154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002204
VERSION     KCXD01002204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13078:7154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60686.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       412..421
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           95 a          142 c          136 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agcatggaca tcctgtgcaa gaacatgaag cacctgtggc
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccctcagaga ccctgtccct cacctgcgct gtctctggtg
      181 cctccatcgg tagttactgg tggacctggg tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatgga aatagtggta gtacctacta cagcccatcc ctcaagagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga accacctctc cctgaagctg aattctgtga
      361 ccaccgcgga cacggccgtg tattactgtg cgaacgtctt aggcccctgg ggcagctggt
      421 cacactactt tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002205             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:9260:5211
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002205
VERSION     KCXD01002205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:9260:5211"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60687.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       266..272
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           74 a           80 c           92 g           74 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
       61 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      121 ctgatgaaag taagaaatac tacgccgact ctttgaaaga ccgattcacc atatccagag
      181 acgactccag gaacatgcta tatcttcaac tgaacaacct gaaattggac gacacggccg
      241 tgtattactg tgcgagagat gtgtatggct gggggcttga ctactggggc cagggagtcc
      301 tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01002206             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:9400:7532
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002206
VERSION     KCXD01002206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:9400:7532"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60688.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       436..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          107 a          111 c          157 g          115 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttcag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgggtctg gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga gtgatgaaag
      301 taagagatac tacggagact ctgtgaagga ccgattcagc atttccagag acaactccaa
      361 gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg tgtattactg
      421 tgcgacagat gcgtttggta gcgggattga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002207             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14697:15598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002207
VERSION     KCXD01002207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14697:15598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60689.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       356..368
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       369..410
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           89 a           87 c          133 g          103 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggctgggt tcagccgggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtagcaa cggcatgcac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cagtgatatc gtttgatgaa agtaagaaat actatgcaga
      241 ctctgtgaag gaccgattca ccgtctccag agacaattcc aagaacatgg tatatcttca
      301 aatgaacaac ttgaaattgg aggacacggc cgtgtattac tgtgtgagag actcttatgg
      361 aagtggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002208             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14943:21168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002208
VERSION     KCXD01002208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14943:21168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60690.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       441..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          111 c          154 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgaagcc tctggattca ccttcagtag ttttggcatg
      241 cactgggtcc gccaggctcc agggcagggg ctggagtggg tggcagttat atcgtatgat
      301 gtaagtaaga aatactacgc agacgctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca cgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtggga gagatgataa tggggtgctt atcgacttct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002209             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11792:12048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002209
VERSION     KCXD01002209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11792:12048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60691.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          120 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaaggg ccgattcacc atctccagag
      361 acaattccaa aaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002210             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16013:16452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002210
VERSION     KCXD01002210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16013:16452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60692.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          110 a          143 c          134 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttatcc atacactggg tgcggcaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctgcagac acagcctaca tggaactgag
      361 tagcctgaca tctgaggaca cggccgtgta ttactgtgcg actggcccta gcggcacctg
      421 gaacgcctgg tacctcgaaa tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002211             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:19430:9945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002211
VERSION     KCXD01002211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:19430:9945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..324
     V_segment       8..261
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <255..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60693.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       272..277
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..324
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        325..>326
                     /gene="IGHG"
BASE COUNT           74 a           81 c           98 g           73 t
ORIGIN      
        1 acatggggcc gggggggtcc ctgagactct cctgtgcagt ctctgggttc accttcagtg
       61 gctctggcat gcactgggtc cgccaggctc cagggaaggg gctggaatgg gtggcggtta
      121 tatcgaatga tggaactaac aaatactacg cagactctct gaaggaccga tttagtatct
      181 ccagagagaa ttccaagaac atgctatatc ttcaaatgaa caacctgaaa ctggaggaca
      241 cggccgtcta ttactgcgcg acagatgcgt ttggtagcgg gattgactac tggggccggg
      301 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002212             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:11104:4245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002212
VERSION     KCXD01002212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:11104:4245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60694.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       405..416
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..474
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           94 a          141 c          137 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagcctttgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcagtaac tactgggcct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg acgtatctct ggtagtggtg ggagcaccgt ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaact gacacgtcca agaaccaggt ctccctgaaa gtgacttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgacagc cggatatagc agcagcgaaa
      421 gcttctacgg tttggattcc tggggccaag gggtcgtcgt catcgtctcc tcagcc
//
LOCUS       KCXD01002213             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7156:18618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002213
VERSION     KCXD01002213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7156:18618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..462
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60695.1"
                     /translation="CARYEDDSGHYYFDSW"
     D_segment       403..411
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>466
                     /gene="IGHG"
BASE COUNT           88 a          134 c          130 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacttgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc atctgcgctg tctctggtgg
      181 ctccatcacc agtagcttct ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atatatggta gtactgggag ttccagttcc aacccctccc tcaagagtcg
      301 agtcaccatt tcaacggaca cgtccaagaa ccagttttcc ctgaaactga gctctgtgac
      361 cgccgcggac accgcctttt atttctgtgc gagatatgaa gatgatagtg gtcattacta
      421 ctttgactcc tggggccagg gagtcctggt caccgtctcc tcggcc
//
LOCUS       KCXD01002214             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9909:10996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002214
VERSION     KCXD01002214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9909:10996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..485
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60696.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       416..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>490
                     /gene="IGHG"
BASE COUNT          119 a          139 c          131 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagct
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaagtaaag gggcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aggttttggt cctgtatatg gtgaaataat
      301 acacacagag aagttccagg gcagagtcag tatgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtctattact gtgcggcagc
      421 tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctccttagcc
//
LOCUS       KCXD01002215             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13448:3753
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002215
VERSION     KCXD01002215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13448:3753"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..426
     V_segment       63..353
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60697.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       354..360
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       381..426
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           99 a          112 c          124 g           93 t
ORIGIN      
        1 acatggggga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
       61 ctgaggtcca actggtgcag tctggggctg aagtaaaggg gcctggggcc tcagtgaagg
      121 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg gtgcgacagg
      181 cccctggaaa aggccttgag tggatgggag gttttggtcc tgtatatggt gaaataatac
      241 acacagagaa gttccagggc agagtcagta tgaccgagga cacgtctaca gacacagcct
      301 acatggagct gagcagcctg agatctgagg acacggccgt ctattactgt gcggcagctg
      361 atagtggtta cccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      421 cctcagcc
//
LOCUS       KCXD01002216             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10426:7313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002216
VERSION     KCXD01002216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10426:7313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60698.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       423..429
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          114 a          140 c          137 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc
      121 tctgaggttc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacgcagaaa agttccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggaac tgatcagcct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca attggctttt ttggtacttc gatttttggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01002217             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18566:4725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002217
VERSION     KCXD01002217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18566:4725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60699.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          120 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcaattatt actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atcatggtgg
      301 ggaaagtaca tactatgcag actccgtgaa gggcagattc accctctcca gagagaacgc
      361 caagaacaca ctatatcttc aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002218             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11910:4032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002218
VERSION     KCXD01002218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11910:4032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..457
     V_segment       104..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60700.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       401..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           86 a          137 c          132 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt ccgagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 gactcaatca gcagttactt ctggaactgg atccgccagg ccccagggaa gggactggag
      241 tggattgggt ttctctatgg tagtgatagt acctcccact acaatccctc cctcaagagt
      301 cgagtcaccc tgtctgtgga cacgtccaac aaccaggtct ccctgatgct gaactctgtg
      361 accgccgcgg acacggccgt ctattactgt gcgaccggga agcggcagct ggatcttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002219             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4423:20251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002219
VERSION     KCXD01002219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4423:20251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..499
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60701.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>506
                     /gene="IGHG"
BASE COUNT          110 a          122 c          155 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tcctcgttgc
      121 tcttttgaaa ggtgtccaat gtgaggtgaa actggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaggttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtgttaatac
      301 tggtggggaa agcccatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aatacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc ggcgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtcc tcagcc
//
LOCUS       KCXD01002220             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:4926:6383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002220
VERSION     KCXD01002220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:4926:6383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..484
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60702.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       423..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          117 a          143 c          130 g           96 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaagttt ccggatacac cttcaccgaa ttatcattgc actgggtgcg ccaggcccct
      241 ggaaaagggc ttgagtgggt gggaagtgtt gaccctgcat atggtgaaat gatacacaca
      301 gagatattcc agggcagaat caccatgacc gaggacacgt caacagacac agcctacatg
      361 gagctaagca gcctgagatc tgaggacacg gccgtttatt actgtgcgat atcatccagc
      421 ggcacctggc tattctggta cttcgatgtc tggggccctg gctccccaat caccatctcc
      481 tcagcc
//
LOCUS       KCXD01002221             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:5094:4880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002221
VERSION     KCXD01002221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:5094:4880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60703.1"
                     /translation="CVREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          114 c          147 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctgttgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgtgagggag gagagatttg gctacagttt tgacttctgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002222             348 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12879:3364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002222
VERSION     KCXD01002222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 348)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 348)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12879:3364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..346
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..346
     V_segment       6..285
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <277..>315
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60704.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       286..291
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..346
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        347..>348
                     /gene="IGHG"
BASE COUNT           82 a           83 c          101 g           82 t
ORIGIN      
        1 acatgggagt ctggaggagg cttggttcag cctggggggt ccctgagact ctcctgtgca
       61 gcctctggat tcaccttcag taactatggc atgcactggg tccgccaggc tccagggaag
      121 gggctggagt gggtggcagt tatttcgtct gatggaagta agaaatacta cgcaaactct
      181 gtgaaggacc gattcaccat ctccagagac aattccaaga acatactcta tcttcaaatg
      241 aacaacctga aattggagga cacggccgtc tattactgtg cgagagatga tatggggacc
      301 ggttttgact actggggcca gggagtcctg gtcatcgtct cctcagcc
//
LOCUS       KCXD01002223             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21244:10283
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002223
VERSION     KCXD01002223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21244:10283"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60705.1"
                     /translation="CARKWAGYGLDSW"
     J_segment       411..459
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           96 a          132 c          132 g          101 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggag cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccct cagcggttac tactggaatt ggatccgcca accaccaggg aaggggctgg
      241 agtggattgg ttatatcgct ggtagtagtg gaagtaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca ggaaccagtt ctccctgaaa ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcaagaaa atgggccgga tacggtttgg
      421 attcctgggg ccaaggggtc gtcgttacag tctcctcagc c
//
LOCUS       KCXD01002224             297 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15739:13002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002224
VERSION     KCXD01002224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 297)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15739:13002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..295
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..295
     V_segment       7..225
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>264
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60706.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       243..247
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..295
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        296..>297
                     /gene="IGHG"
BASE COUNT           68 a           74 c           87 g           68 t
ORIGIN      
        1 acatggggat tcagcttcag ttactactac atgagctggg tccgccaggc tccagggaag
       61 gggctggagt ggatctcagg tcttgccagt ggtggggata gcacatacta tgcagactcc
      121 gtgaagggca gattcaccat ctccagagag aacgccaaga acacactgca tcttcaaatg
      181 gacagcctga gagttgaaga cacggctgtc tattactgtg tgagagatcg acgtgttcag
      241 tcattatcct ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002225             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19909:15613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002225
VERSION     KCXD01002225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19909:15613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60707.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           81 a          139 c          139 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctggccc tcacctgcgc tgtctctggt
      181 ggctccatca gtggttactg gtggggctgg atccgccagt ccccagggag ggggctggaa
      241 tggattggat ttttcggtgg tagtggtggg aacacctact acaagtcctc cctccagagt
      301 cgagtcacca tttcagccga cccgtccaag aaccagttct ccctgatact gacctctgtg
      361 accgccgcgg acacggccct ctattactgt gcgcggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002226             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21639:3325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002226
VERSION     KCXD01002226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21639:3325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60708.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       414..433
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..495
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          139 c          146 g          107 t
ORIGIN      
        1 acatggggga caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtctcagg
      121 tccagctggt gcagtccggg gctgagatgg agaagcctgg ggcctcagtg aagctctcct
      181 gtaaggcttc tggatacacc ttcagcatct atgtcatcag ttgggtgcga caggcccctg
      241 gacaagggct tgagtggatg ggaggcatct tccctcttgt tggtacaaca aactacgcac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacaagcaca gcctacatgg
      361 acctgagcag cctgggatct ggggacacgg ccgtgtatta ttgtgcgaga ggttactgta
      421 ctggtagtgg ttgtaacctt acattcaacc ggctcgatgt ctggggcccg ggagtcccgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002227             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17454:11218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002227
VERSION     KCXD01002227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17454:11218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60709.1"
                     /translation="CAGGAYANLDYW"
     D_segment       435..439
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          124 c          153 g          112 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca aatggtggag tctgggggcg gctttgcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagatactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctcttaatta
      301 tgatggggat agtacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcaaag aacacgctct ccctacaaat gcacagcctg agagaggatg acacggccgt
      421 atatttctgt gcgggtgggg cgtacgctaa cctcgactat tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002228             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9871:8441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002228
VERSION     KCXD01002228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9871:8441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60710.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       437..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          113 c          152 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgcatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctct agagacaatt
      361 ccaagaatac ggtttttctg caaatgaatt ccctgaaaat ggaggacacg gccgtgtatt
      421 actgtgtgag agtccatgac tacgctatgt actactttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002229             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18705:14374
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002229
VERSION     KCXD01002229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18705:14374"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..434
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60711.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       441..451
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          103 a          125 c          161 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcgcag
      181 cctggggggt ccctgaaact cccctgcgca gcctctggat tcagcttcag ctacttctac
      241 atgagctggg tccgccaggc tccaggaaag gggctggagt ggatctcagg gattgacagt
      301 ggtgggggtg acacattcta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga ggacactgta tcttcaaatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg cgaggtctac tgggagctac aggggatact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002230             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19550:14411
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002230
VERSION     KCXD01002230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19550:14411"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60712.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       421..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          103 a          136 c          145 g          100 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccagctg gtgcagtccg gggctgatgt gaagaagcct ggggcctcag tgaagctctc
      181 ctgcaaggct tctggattcg ccttcagaat gtatgccctc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagggat cgtccctctt gttggaacaa caaactccgc
      301 acagaagttc cagggcagag tcacgattac cgcggacacg tccacaagca cagtctacat
      361 ggagttgagc agcctgagat ctgaggacac ggccatgtat tactgtgcga gaggcctggg
      421 tagcagcgcc cactttggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01002231             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16209:6813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002231
VERSION     KCXD01002231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16209:6813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60713.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaatga ccgattcacc atctccagag
      361 acaattccaa gaacacccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002232             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20232:14469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002232
VERSION     KCXD01002232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20232:14469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60714.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          110 c          155 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttattgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatgttca gtaactatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatatcgta
      301 tgatgtaact gtgaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aatacggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01002233             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19456:10755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002233
VERSION     KCXD01002233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19456:10755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60715.1"
                     /translation="CARDVRGTGFDFR"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          116 c          154 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttgag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc attaactatg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgcacagcct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtccggggaa cggggtttga cttccggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002234             437 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:12297:11268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002234
VERSION     KCXD01002234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 437)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 437)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:12297:11268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    57..435
                     /note="immunoglobulin heavy chain variable region"
     V_region        57..435
     V_segment       57..348
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <342..>404
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60716.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       371..377
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       386..435
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        436..>437
                     /gene="IGHG"
BASE COUNT           99 a          114 c          132 g           92 t
ORIGIN      
        1 acatggggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
       61 tccaactggt gcagtctggg gctgaaatga agaagcctgg ggcctcagtt agggtctcct
      121 gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga caggcccctg
      181 gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata atacacgcag
      241 agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca gccttcatgg
      301 aattgagcag cctgacatct gaggacacgg ccgtgtattt ctgtgcgaaa ggggggttcg
      361 gaaccagcgt ctggtccaat ctcttctacg gtttggattc ctggggccaa ggggtcgtcg
      421 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002235             417 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19079:8510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002235
VERSION     KCXD01002235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 417)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 417)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19079:8510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    61..415
                     /note="immunoglobulin heavy chain variable region"
     V_region        61..415
     V_segment       61..354
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>384
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60717.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       364..369
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       373..415
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        416..>417
                     /gene="IGHG"
BASE COUNT           93 a           88 c          128 g          108 t
ORIGIN      
        1 acatgggagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt
       61 gaggtacagc tggtggagtc tggaggagac ttggttcacc ctggggggtc cctgagactc
      121 tcctgtgcag cctctggatt caccttcagt aactttggca tacactgggt ccgccagggt
      181 ccagggaagg ggctggagtg ggtggcagtt atatcgtatg atgaaactag gacatactac
      241 gcagactctg tgaaggaccg attcaccatc tccagagaca atttcaagaa catgatattt
      301 cttcaaatga acaacctgaa attggaggac acggccgtgt attattgtgt gagagatgtc
      361 aggggaacgg ggtttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002236             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13969:5362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002236
VERSION     KCXD01002236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13969:5362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60718.1"
                     /translation="CARDVRGTGFDFW"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          114 c          152 g          118 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttccg
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagctttggc
      241 atacactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtat
      301 gatgaaacta agaaatacta cgcagactct gtgagggacc gattcaccat ctccagagac
      361 aattccaaaa acatggtata tcttcaaatg aacaacctga aattggagga cacggccata
      421 tattactgtg cgagagatgt caggggcacg gggtttgact tctggagcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01002237             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17200:5075
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002237
VERSION     KCXD01002237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17200:5075"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60719.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          140 c          138 g          107 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccgcctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg cggggcttct ggattcaccc tcgacaccta tggtatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtggtcat cccccttatt ggtatcataa
      301 actacgcaaa gaactctcag ggcagactca caataaccgc gaacacgtcc acaaatacag
      361 cctatttgga actgagcagt ctgagatctg aggacacggc catctattac tgtgcgagag
      421 aatactgtac ttctagttct tgcgccgggt tccttgacta ctggggccag ggagccctgg
      481 tcatcgtctc ctcagcc
//
LOCUS       KCXD01002238             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14921:10995
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002238
VERSION     KCXD01002238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14921:10995"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..498
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60720.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>501
                     /gene="IGHG"
BASE COUNT          111 a          119 c          151 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cggcctgggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtaatttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaagaaata ctatgtagac tctgtgaagg accgattcac catctccaga
      361 gacatttcca agaacatagt atatcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgcgagaga cgcatttggc agcggctgtg actactgggg ccggggcgtc
      481 ctggtcaccg tctcctcaac c
//
LOCUS       KCXD01002239             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5974:10754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002239
VERSION     KCXD01002239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5974:10754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60721.1"
                     /translation="CVRYEDESIDYHFDYW"
     D_segment       412..420
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcttggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcatcatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttccgtgac
      361 cgccgcggac accgccatgt attactgtgt gagatatgag gatgaatcca ttgactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002240             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2162:11805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002240
VERSION     KCXD01002240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2162:11805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60722.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       447..455
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          114 c          157 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttcggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgaggc tctcctgtgc agcctctgga ttcaccttca gtcactatgg
      241 cgttcactgg gtccgccagg ctccagggaa ggggctggac tgggtggcag ttatatcgta
      301 tgatgaaaat aagaaatatt acgcggactt tgtgagggac cgattcaccg tctccagaga
      361 caattccaag accatggtat atcttcagat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatg tcagaggcgg tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002241             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13964:15395
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002241
VERSION     KCXD01002241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13964:15395"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..465
     V_segment       87..380
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60723.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       384..403
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..465
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           96 a          126 c          142 g          103 t
ORIGIN      
        1 acatggggct gggaacacag ctcatcacca tggacttgac ctggaggctc ctctttgtgg
       61 tggcagcagc tacaggtgcc cagtctcagg tccagctggt gcagtccggg gctgagatgg
      121 agaagcctgg ggcctcagtg aagctctcct gtaaggcttc tggatacacc ttcagcatct
      181 atgtcatcag ttgggtgcga caggcccctg gacaagggct tgagtggatg ggaggcatct
      241 tccctcttgt tggtacaaca aactacgcac agaagttcca gggcagagtc acgattaccg
      301 cggacacgtc cacaagcaca gcctacatgg acctgagcag cctgggatct ggggacacgg
      361 ccgtgtatta ttgtgcgaga ggttactgta ctggtagtgg ttgtaacctt acattcaacc
      421 ggctcgatgt ctggggcccg ggagtcccgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002242             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16123:16104
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002242
VERSION     KCXD01002242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16123:16104"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60724.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       446..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          157 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cggcctctgg attcaccttc agaacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatgaaac taacaaatac tacggagact ctgtgaaggg ccgattcagc atctccagag
      361 acaattcgaa gaacatgcta tatcttcaaa tgaacaccct gaaattggag gacacggccg
      421 tgtattactg tgcgacagat gcgtttggta gtgggattga ccactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002243             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13842:5552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002243
VERSION     KCXD01002243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13842:5552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..516
     V_segment       135..428
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60725.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       438..444
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..516
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          110 a          117 c          156 g          135 t
ORIGIN      
        1 acatggggag gagccacagc cccgggattc ccagctgtct ccacttggtc atgaacactg
       61 aactcagaag acgcaccatg gagtttgtgc tgagtttgct tttccttgtt gcttttttaa
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggta aagcctgggg
      181 ggtccctgag actctcttgt gtagtctctg gattctcctt cagtaactat gttatgcatt
      241 gggtccgcca ggctccagga aagggtctgg agtgggtctc acttattagt ggaagtggtg
      301 gtaccacaga ctacgcagac tctgtgaagg gccgattcac cctctccaga gacaacgcca
      361 aggaatcgct ttttctgcaa atgaacagcc taagagccga ggacacggcc gtgtattact
      421 gtgctagagg cggggaaata gtggattcag agattattga ggattactac ggtttggatt
      481 tctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01002244             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13033:5710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002244
VERSION     KCXD01002244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13033:5710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60726.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       443..449
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          145 c          142 g          100 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga ggtgatgaag cctggggcct cagtgaagct
      181 ctcctgcaag gcttctggat acaccctcag catctctgcc atcagttggg tacgacaggc
      241 ccctggacaa gggcttgagt ggatgggaga gatcttccct cttgttggtg tgacaaaata
      301 cgcacagaac ttccagggca gagtcacgat taccgcggac acgtccacaa gcacagccta
      361 catggagctg cgcggcctga gatctgagga cacggccgta tattactgtg cgagaagagg
      421 tggccacggt accaccacca cgttgtactt ctttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002245             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17067:13951
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002245
VERSION     KCXD01002245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17067:13951"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60727.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          121 a          140 c          135 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagcgaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatat tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002246             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:27072:19358
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002246
VERSION     KCXD01002246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:27072:19358"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60728.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          115 c          148 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctgggg tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acgcaaactc tgtgaagagc cgattcacca tctccagaga
      361 caattccaag aacatacttt atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002247             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:5726:4444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002247
VERSION     KCXD01002247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:5726:4444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60729.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          110 a          122 c          156 g          127 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcccggggg gtccctgaga ctctcctgtg cagcctctgg attcaaattc agtgactact
      241 ggatgtactg ggttcgccag acacctgagc aggggctgga gtggatctca gctattgata
      301 gtgctggtgc tagtaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002248             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8810:12647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002248
VERSION     KCXD01002248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8810:12647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60730.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       438..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          111 c          150 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagt tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcaga aactttggca
      241 tgcactgggt ccgccaggcc ccagggaagg ggctggattg ggtggcagtt atgtcgtttg
      301 atgaaaatgt gaaattctac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catggtatat cttcaaatga acaacctgaa attggaggac acggccctgt
      421 attactgtgc gagaggggaa tacagtaatt ctattgactt ctggggccag ggagtcctgg
      481 tcaccgtctc gtcagcc
//
LOCUS       KCXD01002249             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11552:9912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002249
VERSION     KCXD01002249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11552:9912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..502
     V_segment       123..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60731.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       424..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>506
                     /gene="IGHG"
BASE COUNT          119 a          139 c          144 g          104 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgcaa ggcttctgga ttcacgttca gcaccgatgc catcagttgg gtgcgacagg
      241 cccctggaca agggcttgat tggatgggag gggtcatccc tcttatgggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacgt ttaccgcgga cacgtcacta agcacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattattgt gcgaaatccg
      421 tgaattacga ggaagataac ggttactata taccgacgca gtttgactac tggggccagg
      481 gagtcctggt caccgtctcc tctgcc
//
LOCUS       KCXD01002250             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:18763:6822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002250
VERSION     KCXD01002250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:18763:6822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..479
     V_segment       107..402
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60732.1"
                     /translation="CATVSSGNYYFLHFEYW"
     D_segment       412..428
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          116 a          114 c          133 g          118 t
ORIGIN      
        1 acatgggggt ctccacttgg tgatcagcac tgaacacagg agactcgcca tggagtttgt
       61 actgagctgg gttttccttg ttgctatatt aaaaggtgtc cagtgtgagg tacaactggt
      121 ggagtctggg ggagacttgg tccagcctgg cgggtccctg agactctcct gtgaagcctc
      181 tggactcacc ttcagtgact atgtcatgag ctgggtccgc caggcttctg ggaaaggact
      241 ggagtgggtt gcctatatta gaagcaaata taacaattac gcgacagaat atgccgcatc
      301 ggtgaaaggc agattcacca tctccagaga tgattcaaag agcacgctat atctgcaaat
      361 gagcagcctg aaaaccgagg acacggccgt gtattactgt gccacagtct ctagtggtaa
      421 ttattacttc ctacactttg aatactgggg ccagggagtc ctggccaccg tcgcctcagc
      481 c
//
LOCUS       KCXD01002251             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21718:12865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002251
VERSION     KCXD01002251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21718:12865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60733.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          116 c          146 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtcc aactggtgga gtctggagga ggcttggttc
      181 aaccgggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaaact ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatactt tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002252             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14548:9516
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002252
VERSION     KCXD01002252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14548:9516"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60734.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       405..411
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           87 a          144 c          132 g           99 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtttctggt
      181 ggctccatca gcagtgactt ctggagctgg atccgccagc cccccgggaa gggactggag
      241 tggattggac gtgtctatgg tagcactgat agcaccagct acaacccctc cctcacgagt
      301 cgagtcacca tttcaataga cacgtccaag aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt ttattactgt gcgagagatg cgggaactgg gacccccttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002253             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21601:16615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002253
VERSION     KCXD01002253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21601:16615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60735.1"
                     /translation="CVRDEYGSGLGFW"
     D_segment       448..457
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          112 c          153 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctatcttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattaagctt cagtaacttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttctatcg
      301 tcagatgaaa ataaaaagta ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca ggaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 atttattact gtgtgagaga tgagtacggt agtggtttag gcttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002254             305 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14932:17294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002254
VERSION     KCXD01002254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 305)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 305)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14932:17294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..303
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..303
     V_segment       8..227
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <219..>272
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60736.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       229..235
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       262..303
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        304..>305
                     /gene="IGHG"
BASE COUNT           69 a           75 c           94 g           67 t
ORIGIN      
        1 acatgggcgg atacaccttc accgatttat ccatgcactg ggtgcgacag gcccctggaa
       61 aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata tacgcagaga
      121 acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggagc
      181 tgagtagcct gagatctgag gacacggccg tttattactg tgcgagaggt gtgacagcag
      241 acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc accgtctcct
      301 cagcc
//
LOCUS       KCXD01002255             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11510:17120
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002255
VERSION     KCXD01002255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11510:17120"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60737.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          107 a          116 c          163 g          111 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcacagcctg
      181 gggggtccct gagactctcc tgtgcagcca ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctcaggtatt aatagtggtg
      301 gggatagaac atactacgca gactccgtga agggccgatt caccatgtcc agagacaact
      361 caaagaacac tctctccctg caaatgaaca gcctgagagc ggaggacacg gccgtgtatt
      421 attgtgtgca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002256             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:19371:16138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002256
VERSION     KCXD01002256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:19371:16138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..444
     V_segment       90..383
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60738.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       387..399
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          102 a          100 c          133 g          111 t
ORIGIN      
        1 acatgggcag cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc
       61 ttgttgctat tttaagaggt gtccagtgtg aggtgcagtt ggcggagtct ggaggaggct
      121 tggttcagcc tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta
      181 actttggcat gcactgggtc cgtcaggctc caggaaaggg gctggagtgg gtggcagtta
      241 tctcgtctga tggaagttac aaatactacg aagactcttt gaaggaccga ttcaccatct
      301 ccagagacaa ttccaggaac atgcaatatc ttcagatgaa caacctgaaa ttggaggaca
      361 cggccgtgta tttctgtgcg agaggggaat acagtaactc tattgacttc tggggccagg
      421 gagtcctggt caccgtctcg tcagcc
//
LOCUS       KCXD01002257             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20917:12177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002257
VERSION     KCXD01002257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20917:12177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60739.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          103 a          123 c          155 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcatc cggattcagc ttcagtgacc actgcatgca
      241 ctgggtccgc caggcttcag ggaaggggct ggagtgggtc tcaggtatta cttatactgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgtggga ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002258             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19099:7967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002258
VERSION     KCXD01002258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19099:7967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60740.1"
                     /translation="CAREYCTSDSCAGFFDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          110 a          134 c          136 g          105 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 acttggtgca gtccggggct gaggtgagga agcctggggc ctcagtgaag gtttcctgca
      181 agacttctgg attcaccctc gacaactatg gaatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttgtcgg tattgtgaac tacgtagaca
      301 ccctccaggg cagagccacg ataaacgcgg acacgtcaac aaatacagtc tacatggaac
      361 tgaacagcct gagatctggc gacacggcca tctattactg tgcgagagaa tactgtactt
      421 ctgattcttg cgccggattc tttgactact ggggccaggg agtcctggtc accgtctctt
      481 cagcc
//
LOCUS       KCXD01002259             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19209:18754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002259
VERSION     KCXD01002259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19209:18754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60741.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          114 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gaactgggtt ttccttgtta
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaag tagaaaatac tacccagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccga ggccaatgtg tatcttcaaa tgaatgacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcgtatggtt ccggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002260             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16148:7588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002260
VERSION     KCXD01002260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16148:7588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60742.1"
                     /translation="CATGRFGSSVWSSLFYGFDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          139 c          150 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgagatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccagga cagagtcacc atgaccgagg acacgtctat agacatagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt ttgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002261             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18497:11380
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002261
VERSION     KCXD01002261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18497:11380"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60743.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          126 c          152 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tattctatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcaggtatt agtactgctg
      301 ggaccacata ttacacagac tccgtgaagg gccgattcac catctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc ctgtattact
      421 gtgcgaaagg ggagacagct tcagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002262             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19528:15577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002262
VERSION     KCXD01002262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19528:15577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60744.1"
                     /translation="CARGDSGIYYYFDSW"
     D_segment       452..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          117 a          113 c          153 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggaac acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtagtgatg
      241 tcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatggaag taagaagtat tatgtagact ctgtgaggga ccgattcgcc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagga gatagcggta tttattacta ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002263             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24876:15060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002263
VERSION     KCXD01002263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24876:15060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60745.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          102 a          123 c          164 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa aataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctgaga ctctcctgcg cagtctctgg attcagtttc agtcactact
      241 tcatgagttg ggtccgccag gctccaggga aggggctgga gtggatctca gggattaaca
      301 gtggtgggga aaccacacac tatgcggact ccgtgaaggg cagattcacc atgtccagag
      361 agaacgccaa gaacacactg tctcttcaaa tggacggcct gagagctggg gactcggctg
      421 tctatttctg tgcgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002264             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:27290:6420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002264
VERSION     KCXD01002264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:27290:6420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60746.1"
                     /translation="CAKTYYSGTLEFW"
     D_segment       420..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..477
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           93 a          147 c          131 g          108 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggggcag aggtgagaag gcccggggag tctctgagga
      181 tctcctgtaa gacttctgga tacagcttta ccaccagctg ggtcagttgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccctc cttccaaggc cccgtcacta tctcagtcga caactccatc agtaccacct
      361 acctgcattg gagcagcctg aaggcctcgg acaccgccac atatttctgt gcgaaaacct
      421 actatagtgg tactttggag ttctggggcc agggagccct ggtcaccgtc gcctcagcc
//
LOCUS       KCXD01002265             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12429:12562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002265
VERSION     KCXD01002265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12429:12562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60747.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          109 c          157 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctgga ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgtagcctc tggattcatc ttcagtagta gtggcatgca
      241 ctgggtccgc cagggcccag ggaaggggct ggagtgggtg gccgttaaat cgcatgatgg
      301 aaataagaag tactatgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc agatgaacaa cctgaaattg gaagatacgg ccgtgtatta
      421 ctgtgtgaga gatgcctacg ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002266             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8929:17631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002266
VERSION     KCXD01002266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8929:17631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60748.1"
                     /translation="CARMECTGGVCYFDYW"
     D_segment       451..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          113 a          116 c          156 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtcatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tctattactg tgcgagaatg gagtgtactg gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002267             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14913:12047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002267
VERSION     KCXD01002267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14913:12047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60749.1"
                     /translation="CARERCNTRVCAGFFDYW"
     D_segment       424..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          143 c          139 g           97 t
ORIGIN      
        1 acatggggac aaaacaacca catccctcct ctaaagaagc ccctgggagc acagctcatc
       61 accatggact ggacctggag gctcctcttt gtggtggcag cagctacagg tggccagtcc
      121 caggtccagg tggtgcagtc cggggctgaa gtgaagaagc ccggggcctc agtgaaagtt
      181 tcctgcaagg cctctggatt caccctcgac aactttggca tcaactgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggagtg accatccccc ttgttgggat aattaactac
      301 gcagagaagt tccagggcag agccacactt accgcggaca cgtccacaaa cacagcctac
      361 atggaactga ccggcctgat atctgaggac acggccatct attactgtgc gagagaacgc
      421 tgtaatactc gtgtttgcgc cggcttcttt gactactggg gccagggagt cccggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002268             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21974:12252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002268
VERSION     KCXD01002268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21974:12252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..490
     V_segment       139..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60750.1"
                     /translation="CANALTGGLDYW"
     D_segment       437..445
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          108 a          122 c          156 g          106 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcacc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggcggctt ggcaaaacct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag atactggatg
      241 aactgggtcc gccaggctcc agagaagggg ctggagtggg tctcaggtat taatagtggt
      301 ggggatagca cacactacgc agactccgtg aagggtcgat tcaccatctc cagagacaac
      361 tcaaagaaca cgctctccct gcaaatgaac agccttagag cggaggacac ggccatatat
      421 tactgtgcga acgcgttaac tggggggctt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002269             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14459:17008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002269
VERSION     KCXD01002269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14459:17008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..490
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60751.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       441..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          117 a          113 c          147 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgaactgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggagggttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcaatacct atggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgaatgatga
      301 aactaaaaaa tactacgcag actctgtgaa ggaccgattc accatttcca gagacaattc
      361 caagaacatg ctatatcttc aaatggacaa cctgaaattg gaggactcgg ccgtgtatta
      421 ctgtgtgaga gacgcatttg gcagcggctg tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca acc
//
LOCUS       KCXD01002270             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:18418:9136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002270
VERSION     KCXD01002270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:18418:9136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60752.1"
                     /translation="CARADRGSSIDFW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          116 c          146 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggcg gttatatctt
      301 atgatgatga taagaaatac tacacagact ctttgaagga ccgattcacc atatccagag
      361 acaattccaa gaacactctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagagcg gatcgcggca gttcaattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002271             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9964:7913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002271
VERSION     KCXD01002271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9964:7913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60753.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       446..451
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          109 a          114 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggaccccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatgttaag aggtgtccag tgtgaggtgc agatggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcat
      301 atgatgaaat tacgaaatac tacgcagact ctgcgaagga ccgattcacc atctccagag
      361 acaattccaa gaatgtggta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtatttctg tgcgagaggg gattttggta atggcgtcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01002272             536 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14164:15607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002272
VERSION     KCXD01002272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 536)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 536)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14164:15607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    156..534
                     /note="immunoglobulin heavy chain variable region"
     V_region        156..534
     V_segment       156..447
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <441..>503
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60754.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       463..474
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       488..534
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        535..>536
                     /gene="IGHG"
BASE COUNT          123 a          154 c          155 g          104 t
ORIGIN      
        1 acatggggga ggtaaataca gatctgtcct tgtccagaga gcatcacaca acaaccacat
       61 ccctccccta cagaagcccc agagcacagc acctcaccat ggactggacc tggaggatcc
      121 tcctcttggt ggcagcagct acaggcgccc actctgaggt ccacctggtg cagtctgggg
      181 ctgaggtgaa gcagcctggg gcctcagtga aggtctcctg tcaggtttcc ggatacaccg
      241 tcaccgaatt atccatgcac tgggtgcgac aggcccctgg gaaagggctt gagtggatgg
      301 gagttgttga tcctgtcaat ggtgaagaaa ttcacgcaga gaacttccag ggcagagtca
      361 ccatgaccga ggacacgtcg acagacacag cctacatgga cttgaccagt ctcagatctg
      421 aggacacggc catctattac tgtgcgacag ggaggatcgg tggcagcggc tggtccaacc
      481 tcttcaccgg tttggaatcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002273             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11374:15736
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002273
VERSION     KCXD01002273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11374:15736"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    130..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        130..499
     V_segment       130..423
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <415..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60755.1"
                     /translation="CAREYCTSDACAGFFDYW"
     D_segment       424..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          120 a          137 c          141 g          103 t
ORIGIN      
        1 acatggggga gagcatcaca aaacaaccac atccctcctc taaagaagcc cctgggagca
       61 cagctcatca ccatggactg gacctggagg ctcctctttg tggtggcagc agctacaggt
      121 gtccagtccc aggtccactt ggtgcagtcc ggggctgagg tgaagaagcc tggggcctca
      181 gtgaaggttt cctgcaaggc ttctggattc accctcgaca actatggaat caactgggtg
      241 cgacaggccc ctggacaagg gctggagtgg atgggagtga tcatccccct tgtcggtata
      301 gtgaactacg tagagaacct ccagggcaga gccacgataa ccgcggacac gtcaacaaac
      361 acagtctaca tggaattgaa cagcctgaga tctgacgaca cggccatcta ttattgtgcg
      421 agagaatact gtacttctga tgcttgcgcc ggattctttg actactgggg ccagggagtc
      481 ccggtcaccg tctcttcagc c
//
LOCUS       KCXD01002274             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19810:5861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002274
VERSION     KCXD01002274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19810:5861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..463
     V_segment       85..378
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60756.1"
                     /translation="CARGTTHLETAAGIGDYFDSW"
     D_segment       398..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          103 a          132 c          142 g           88 t
ORIGIN      
        1 acatgggggg gaacacagct catcaccatg gacttgacct ggaggctcct ctttgtggtg
       61 gcagcggcta caggtgccca gtcccaggtc cagctggtgc agtccggggc tgaggtgaag
      121 aagcctgggg cctcagtgaa gctctcctgc aaggcttccg gatacacctt cagcatccat
      181 ggcatcagtt gggtgcgaca ggcccctgga caagggcttg agtggatggg agggatcatc
      241 cctcttgttg atttaacaca ctacgcacag aagttccagg gcagagtcac aattaccgcg
      301 gacacgccca caagcacagc ctacatggag ctgagcagcc tgagatctga ggacacggcc
      361 gtatattact gtgcgagagg gacaacccac ctcgagacgg cagctggaat cggagactac
      421 tttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002275             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20314:16768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002275
VERSION     KCXD01002275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20314:16768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60757.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          114 a          137 c          137 g          101 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag caggtacagg cgcccactct
      121 gaggtccagc tggtgcagtc gggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgtaagg tttccggata caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctg tttttggtga aataatgaat
      301 tcagagaagt tccagggcag agtcgccttg accgaggaca cgtctacaga cacagcctac
      361 atggagttga gcagcctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatattg gtacttcgat gtctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01002276             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21634:14216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002276
VERSION     KCXD01002276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21634:14216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60758.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          138 c          130 g          106 t
ORIGIN      
        1 acatggggga cgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tacatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgaatcacc atttcaacag acacgtccaa gaaccagttt tccctggggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaatta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002277             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:7049:16744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002277
VERSION     KCXD01002277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:7049:16744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..469
     V_segment       115..408
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60759.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       412..424
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          110 a          104 c          137 g          120 t
ORIGIN      
        1 acatgggggt ccacagtgtt ccgttcggtg atcagcacag aacacagagg actcaccatg
       61 aagtttgggc tgagctgggt tttccttgtt gctgttttaa gaggtgtcca gtgtgaggtg
      121 caattggtgg agtctggagg aggcttgatt cagcctgggg ggtccctgag gctctcctgt
      181 gcagcctctg gattcacctt cagtaattat ggcttgcact gggtccgcca ggctccagtg
      241 aaggggctgg agtgggttgc agttatatcg tatgatgaaa atgtgaaata ctacgcagac
      301 tctgtaaagg accgattcac catctccaga gacaattcca agaacatgct atatcttcaa
      361 atgaacaacc tgaaattgga ggacacggcc gtgtattact gtgcgagagg ggaatacagt
      421 aactctattg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002278             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10870:16321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002278
VERSION     KCXD01002278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10870:16321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..514
     V_segment       143..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60760.1"
                     /translation="CAKRGWAGSWNGGHYFDYW"
     D_segment       448..460
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>517
                     /gene="IGHG"
BASE COUNT          106 a          131 c          163 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggtcca
      181 gcctgggggg tctctgagac tctcctgttc agcctctgga ttcactttca gtagctattc
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattactaa
      301 tggtggtgtt accacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcgatg gacacgctct ccctgcaaat gaacagcctg agagctgagg acacggccgt
      421 gtattactgt gcgaaaagag ggtgggccgg cagctggaac ggggggcact actttgacta
      481 ttggggccag ggagtcctgg tcaccgtctc ctcaccc
//
LOCUS       KCXD01002279             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:1951:12861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002279
VERSION     KCXD01002279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:1951:12861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..473
     V_segment       107..398
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60761.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       404..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          141 c          132 g          110 t
ORIGIN      
        1 acatgggggc tgtctgagag tcagggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag gtcccagatg ggtcctgtcc cagccgcagc tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcgact gcgttgtctc
      181 tggtggctcc atcagcgatt actcctggag ctggatccgc cagcccccag ggaagggact
      241 ggagtggatt gggaatattg atgttcatct tgcgggcccc aactacaccc cctccctcaa
      301 gagtcgagtc gccatttcaa aagacacgtc caagaatcag ttctccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtatattt ctgtgcgaaa caatatagtg gtagttatta
      421 ctattcccac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002280             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20480:12284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002280
VERSION     KCXD01002280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20480:12284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..493
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60762.1"
                     /translation="CARGDIGNGVDYW"
     D_segment       437..444
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          108 a          114 c          153 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 tgttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt atctttggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcgtatg
      301 atgaaattac gaaatactac gcagactctg cgaaggaccg attcaccatc tccagagaca
      361 attccaagaa tatggtatat cttcaaatga acagcctgaa attggaggac acggccgtgt
      421 atttctgtgc cagaggggat attggtaatg gcgtcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01002281             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14235:11297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002281
VERSION     KCXD01002281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14235:11297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    162..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        162..444
     V_segment       162..383
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60763.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       385..389
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..444
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          101 a          103 c          133 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggattc accttcagta
      181 cctctggcat gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtgtctgtaa
      241 tttcgtctga tggaagtaag aaatactacg cagactctgt gaaggaccga ttcaccatct
      301 ccagagacaa ctccaagaac atactatatc ttcaaatgaa caacctgaaa ttggaggaca
      361 cggccgtgta tttctgtgtg agagatgcct tcgggggcgg tttggattcc tggggccaag
      421 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002282             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9281:21432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002282
VERSION     KCXD01002282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9281:21432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60764.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          109 c          154 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgg ccagtgtgag gtgaagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgcgcagctt ccggattcac cttcagtttc tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttaca tcgaatgatg
      301 aaagtaagaa atactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat agtatatctt caaatgaaca acctgaaatt gaaggacacg gccgtgtact
      421 actgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002283             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9453:12434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002283
VERSION     KCXD01002283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9453:12434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..442
     V_segment       76..372
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60765.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       388..393
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..442
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           86 a          134 c          125 g           99 t
ORIGIN      
        1 acatgggtgt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gggtcgggcc cagggctggt gaagccttcg
      121 gagaccctgt ccctcacctg cgctgtttct ggtgactcca tcaacagtgg ctactactgg
      181 agttggatcc gccaatcccc agggaggggg ctggagtgga ttgggtctat cggtggtagt
      241 agtggcagca cctactacaa cccctccctc aagagtcgag tcaccctttc aaaagacacg
      301 tccaggaacc agttctccct gaaactgagc tctgtgaccg ccgcagacac ggccgtttat
      361 tactgtgcga gaaaacttcc aggtctccaa ctaaccggtt tcgattcctg gggccaaggg
      421 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002284             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17132:18637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002284
VERSION     KCXD01002284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17132:18637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60766.1"
                     /translation="CASPLLPATGNW"
     D_segment       412..419
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          131 c          132 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgatg tctctggtca
      181 ttccatcaat agtggttact cctggggctg gatccgtcag cccccaggga agggactgga
      241 gtggattggg tttatcggtg gtcgtagtgg gtacacctac tacaacccct ccctcaggag
      301 tcgagtcagt atctcaaaag acacgtccaa gaaccagttc tccctggaag tgagttctct
      361 gagcgccgcg gacacggccg tgtattattg tgcgagtcct ctccttccgg caactggaaa
      421 ctggggccag ggagtcctgg tcatcgtctc ctcagcc
//
LOCUS       KCXD01002285             276 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19198:2997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002285
VERSION     KCXD01002285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 276)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 276)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19198:2997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..274
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..274
     V_segment       8..189
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <181..>243
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60767.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       210..216
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       229..274
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        275..>276
                     /gene="IGHG"
BASE COUNT           61 a           67 c           88 g           60 t
ORIGIN      
        1 acatggggac aggcccctgg aaaagggctt gagtggttgg gaggtgttga tcctgcaaat
       61 ggtgaggaaa tacacgcaga tagttttcag ggcagagtca ccatgaccga ggacacgtct
      121 acactcacag cctacatgga gctgagcggc ctgagatctg aggacacggc cgtgtattac
      181 tgtgcgagag ggcaattcgg taccagcgtc tggtccaatc tcgtctatgg tttggattcc
      241 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002286             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9630:7163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002286
VERSION     KCXD01002286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9630:7163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..476
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60768.1"
                     /translation="CAIGPSGNWIHWSFDVW"
     D_segment       411..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>480
                     /gene="IGHG"
BASE COUNT          105 a          148 c          134 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaactgt ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgatg
      301 ttccagggca gagtcacaat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga cacctgacga cacggccgtc tattactgtg cgattggccc tagcggcaac
      421 tggatccact ggtccttcga tgtctggggc cctggcaccc caatcaccat ctcctcggcc
//
LOCUS       KCXD01002287             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16504:6589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002287
VERSION     KCXD01002287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16504:6589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60769.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          142 c          150 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccaggg cagagtcacc atggccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgac gacacggccg tatattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002288             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10045:8748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002288
VERSION     KCXD01002288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10045:8748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60770.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          120 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatgggac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattactg tgcgagagga gactacggta acagccttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01002289             316 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9244:9226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002289
VERSION     KCXD01002289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 316)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 316)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9244:9226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..314
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..314
     V_segment       4..249
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>283
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60771.1"
                     /translation="CTGGAYANLDYW"
     D_segment       263..267
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..314
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        315..>316
                     /gene="IGHG"
BASE COUNT           73 a           91 c           91 g           61 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtcgctactg
       61 gatgaactgg gtccgccagg ctccaggaaa gggactggag tgggtctcag ctattaatag
      121 tgatggggag aacacatact acgcagactc cgtgaagggc cgattctcca tctccagaga
      181 caactcaaag aacacgctct ccctgcaaat gaacagcctg agaccggagg acacggccgt
      241 gtattactgc acgggcgggg catacgctaa cctcgactac tggggccagg gagtcctggt
      301 caccgtctcg tcagcc
//
LOCUS       KCXD01002290             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20656:14140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002290
VERSION     KCXD01002290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20656:14140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60772.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          140 c          130 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca atcaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagttggta cagtctgggg ttgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccagtcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01002291             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:25071:6364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002291
VERSION     KCXD01002291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:25071:6364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60773.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       420..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          109 a          142 c          146 g          106 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 ctcaggtcca gctggtgcag tccggggctg agatggagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacaccttca gcatctatgt catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag gcatcttccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga ttaccgcgga cacggccaca agcacagcct
      361 acatggacct gagcagcctg ggatctgggg acacggccgt gtattattgt gcgagaggct
      421 actgtactgg tagtggttgt aaccttacat tcaaccggct cgatgtctgg ggcccgggag
      481 tcccggtcac cgtctcctca gcc
//
LOCUS       KCXD01002292             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:25493:13561
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002292
VERSION     KCXD01002292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:25493:13561"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60774.1"
                     /translation="CAREYCTTRDCAGFLDSW"
     D_segment       420..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          140 c          141 g          100 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aagtctcctg caaggcttct ggattcacct tcgacaacta tggtatcaac tgggtgcgac
      241 aggcccctgg acaggggctt gagtggatgg gagtgatcat cccccttatt ggtataataa
      301 actacgaaga gaacgtccag gacagagtca cgatttccgc ggacacgtcc acaaacacag
      361 cctacatgga ggtgcgcagc ctgagatctg aggacacggc catctattac tgtgcgcgag
      421 aatactgtac cactagggat tgcgccggat tccttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002293             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19746:12304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002293
VERSION     KCXD01002293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19746:12304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60775.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       453..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          114 a          117 c          153 g          130 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgtgga gcagctggtg gaatctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct ggattcacct tcagtagctt
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtctg gactgggtat caggtattaa
      301 cattggcggt gacacgtact acccagactc tgtgaagggt cgattcacta tgtccagaga
      361 caatgccaag aactccgtgt atcttcaaat gaacagcctg agagttgagg acactgctgt
      421 gtatttttgt gcaaggggga tagataacta ccactatagt gatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002294             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11908:15460
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002294
VERSION     KCXD01002294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11908:15460"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60776.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       453..460
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          130 c          157 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gtccagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcatacatt agtattggtg
      301 gtagaaatag aaactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 cagagaaaac gctctccctg caaatgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgcgtc gaacctgcgt ggaaacacct acacttactg gcggtctttt gactcctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002295             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22122:18870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002295
VERSION     KCXD01002295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22122:18870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60777.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          141 c          128 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat gcctgcactg ggttcgacag
      241 gcccctggaa aagggcttga gtggatggga agttttaatc ctatatatgg tgaaatttta
      301 caaacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01002296             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20382:3438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002296
VERSION     KCXD01002296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20382:3438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..470
     V_segment       117..408
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60778.1"
                     /translation="CATADYGNSLDFW"
     D_segment       414..425
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>473
                     /gene="IGHG"
BASE COUNT          107 a          114 c          137 g          115 t
ORIGIN      
        1 acatggggaa gtccacagtg ttccattcgg tgatcaacac agaacacaga ggactcacca
       61 tgaagtttgg gctgagctgg gttttccttg ttgctatttt aagaggtgtc cagtgtgagg
      121 tgcagctggt ggagtcgggg ggaggcttga ttcagcctgg ggggtccctg agactctcct
      181 gtgcagcctc tggattcacc ttcagtagct ttggcatgca ctgggtccgc caggctccag
      241 ggaaggggct ggagtgggtg gcagttacat cgtctgatgg aagtatgaca tactacgcag
      301 actctatgaa ggaccgattc accatctcca gagacaattc caagaacatg ctatatcttc
      361 aagtgaacaa cctgaaattg gaggacactg ccgtttatta ctgtgcgaca gccgactacg
      421 gtaacagcct tgacttctgg ggccagggag tcctggtcac cgtctcctca acc
//
LOCUS       KCXD01002297             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13759:3218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002297
VERSION     KCXD01002297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13759:3218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60779.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       417..427
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          129 c          138 g          112 t
ORIGIN      
        1 acatgggatc acaaaacaac cacatccctc ctctaaagaa gcccctggga gcacagctca
       61 tcaccatgga ctggacctgg aggctcctct ttgtggtggc agcagctaca ggtgtccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tttcctgcaa ggcttctgga tttaccttcg acaactatgg aatcaactgg gtgcggcagg
      241 cccctggaca agggcttgag tggatgggcg tggtcatccc ccttgttggt attattaatt
      301 atgcagagaa cttccagggc agagtaacga ttaacgcgga cacgtccata aacacagcct
      361 tcatggaatt caggagcctg agatctgacg acacggccat ttatttctgt gcgagagaat
      421 actgtacaac tactgattgc gccgggttct ttgactactg gggccaggga gtcatggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002298             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17622:16396
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002298
VERSION     KCXD01002298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17622:16396"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60780.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          119 c          153 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tatgatgaga ctaagaaata ctacgcagac tctgtgaagg accgattcag catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01002299             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11629:9146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002299
VERSION     KCXD01002299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11629:9146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60781.1"
                     /translation="CARYEGAAAGTWFFDYW"
     D_segment       428..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT           97 a          146 c          139 g          111 t
ORIGIN      
        1 acatggggga gggtccagct tacatgggaa atgctctctg agagtcatgg acctcctgtg
       61 caagaacatg aagcacctgt ggttcttcct tctcctggtg gcagctccca gatgggtcct
      121 gtcccaggtg cacctgcagg agtcgggccc aggactggtg aagccttcgg agaccctgtc
      181 cctcacctgc gctgtctctg gtggctccat caccaatcat tactggaact ggatccgcca
      241 gccccccggg aagggactgg agtgggttgg gtctctctat ggtgctactg ggagcaccaa
      301 ctataatccc tccctcaaga gtcgagtcag catttcaaca gacatgtcca agaaccaatt
      361 ttccctgaaa ctgacctctg tgaccgccgc ggacaccgcc gtctattact gtgcgagata
      421 tgagggggcg gcagctggaa cctggttctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002300             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6353:8916
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002300
VERSION     KCXD01002300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6353:8916"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60782.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       417..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          119 a          141 c          135 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaggtggtg cagtctgggg ctgaggtgaa ggagcctggg gcctcagcga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctatat ggtgaaatga
      301 aacacacaga gttccatgcc agattcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagtt gagcagccta agatctgagg acacggccct gtattattgt gcagtcgggt
      421 atagcggccg atggaacaac tggtacttcg atctctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002301             275 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15146:7029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002301
VERSION     KCXD01002301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 275)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 275)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15146:7029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..273
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..273
     V_segment       8..196
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <189..>242
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60783.1"
                     /translation="CTRGIDNYHFSNTDFDFW"
     D_segment       208..215
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       229..273
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        274..>275
                     /gene="IGHG"
BASE COUNT           65 a           65 c           75 g           70 t
ORIGIN      
        1 acatggggca ctgggttcgc caggctccag ggaagggtct ggagtgggtt tccggtatta
       61 acattggcgg tgacacatac tacccagact ctgtgaaggg tcgattcact atctccagag
      121 acaacgccaa gaactccttg tatcttctaa tgaacagcct gagagttgag gacactgctg
      181 tgtatttttg tacaaggggg atagataact accactttag taatacggac tttgacttct
      241 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002302             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19660:17266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002302
VERSION     KCXD01002302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19660:17266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..491
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60784.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       418..432
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          141 c          142 g          102 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggatcca ccttcaccga attatccata cactgggtgc ggcaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgctcctcta tatggtgaaa tgatgctcgc
      301 agacaacttc cagggcagag tcaccttgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgacgacac ggccgtgtat tactgtgcgc gtgggcctat
      421 tacaattttt ggcgtactta ttacggggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002303             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:7619:16316
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002303
VERSION     KCXD01002303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:7619:16316"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60785.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       445..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          111 c          154 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcttctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgcctgg ctccggggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg aaattgaagg acacggccgt
      421 atactactgt gggagagatg ataatggggt gattatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002304             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16957:11040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002304
VERSION     KCXD01002304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16957:11040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60786.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          115 c          158 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gtttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctctgg
      241 catgcactgg gtccgccagg ctccagggca ggggctggat tgggtggcag ttgaatcgtt
      301 tgatggaggt aagaaatact acgctgactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gagcaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002305             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13777:17921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002305
VERSION     KCXD01002305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13777:17921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60787.1"
                     /translation="CARYEEGGTTFDYW"
     D_segment       404..408
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           89 a          133 c          136 g           99 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc cttacctgcg ctgtctctgg
      181 tggggacatc accagtagct actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattgga tatatctatg gtggtagtgg gagcaccggc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaccag acacggccaa gaaccagttt tccctgaggt ctgtgaccgc
      361 cgcggacacc gccgtatatt tctgcgcgcg atatgaagag ggcggaacca cctttgacta
      421 ctggggccag ggagtcctgg tcatcgtctc ctcagcc
//
LOCUS       KCXD01002306             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10067:17271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002306
VERSION     KCXD01002306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10067:17271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60788.1"
                     /translation="CARSRSGSWLYWYFDFW"
     D_segment       426..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          147 c          134 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc gggtacacct tcaccgaatt ttccatgcac tggctacgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgctttt ggtgaaatga
      301 tacacgcaga gaaattccag aacagagtca ccctgaccga ggacacctct acagacacag
      361 cctacatgga actgactagc ctgagatctg aggacacggc cgtgtattac tgtgcgcgat
      421 cacgcagcgg cagctggcta tactggtact tcgatttctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01002307             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5193:11931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002307
VERSION     KCXD01002307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5193:11931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60789.1"
                     /translation="CARDAYGTGFDFW"
     D_segment       442..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          120 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttctccctca gtagatttgg
      241 cattcactgg gtccgccaga ctccagggaa ggggctggag tgggtgacag ttgtctcgtc
      301 tgatggaact aagacatact acgcagactc tgtgaaggac cgattcacta tctccgggga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgcgagacg cctacggtac cggctttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002308             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23441:10315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002308
VERSION     KCXD01002308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23441:10315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60790.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       418..426
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          112 a          142 c          131 g           92 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag caactacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgaa atgatgcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg ggtgggaagt gttgatcctg catatggtga aatgacgttc
      301 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagc
      361 agcctgacat ctgaggacac ggccgtgtat tactgcgcga ttggccctag tggcagatgg
      421 aacgactggt ccttcgacat ctggggacct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01002309             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:19602:13346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002309
VERSION     KCXD01002309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:19602:13346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60791.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       448..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          114 c          154 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgtt
      301 tgatgatagt aagaaatact acgtagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cttacggtag tggctgggac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002310             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19066:10292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002310
VERSION     KCXD01002310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19066:10292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60792.1"
                     /translation="CARWGDSQSIYFFDSW"
     D_segment       398..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          141 c          128 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acatgcgctg tctctggtga
      181 ctctattacc aatagtcact ggtggaactg gatccgccag cccccaggga aagggctgga
      241 atggattgga tatatcagtg gttctactgg tagcaccgac tatcatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttc tccctggaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg ggtgactccc agtccattta
      421 cttctttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002311             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11155:8122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002311
VERSION     KCXD01002311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11155:8122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60793.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          113 c          151 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aagtctgtga aggaccgatt caccatatta agagacaatt
      361 ccaacagcat gctctatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002312             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16970:23066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002312
VERSION     KCXD01002312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16970:23066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60794.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          115 c          157 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgt caggctccag ggaaggggct ggagtggatc tcaagtattg acagtggtgg
      301 gactaccgca aattatgcag actccgtgag gggcagattc atcatctcca gagagaacgc
      361 caagaatata gtgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcgcgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002313             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:19654:11022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002313
VERSION     KCXD01002313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:19654:11022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60795.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactatgta gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat agtatatctt caaatgaaca acctgaactt ggacgacacg gccgtctatt
      421 actgtgcgag agacgcattt ggcagcggct gtgactactg gggccggggc gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002314             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:23848:17342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002314
VERSION     KCXD01002314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:23848:17342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..437
     V_segment       83..378
                     /gene="IGHV2-173"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60796.1"
                     /translation="CARRLWGRFDSW"
     D_segment       385..391
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT           93 a          134 c          111 g          101 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tccacgctcc tgctgctgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtccta cgctggtgaa
      121 acccacacag accctcacgc tgacctgtac cttctctggg ttctcaatca gttctactga
      181 tacgggtgtg agctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccgt
      241 ttattgggat aatgataagt tcttcggcac atctctgaag aacagactca ccatctccaa
      301 ggacacctcc aaaaaccagg tggttctcac aatgaccaac atggaccctg tggacacagc
      361 cacatattac tgtgcacgac gactctgggg aaggtttgac tcctggggcc agggagtcct
      421 ggtcagtgtc tcctcagcc
//
LOCUS       KCXD01002315             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21109:3019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002315
VERSION     KCXD01002315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21109:3019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60797.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atttccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattactg tgcgagggga gactacggta acagccttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01002316             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19168:12891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002316
VERSION     KCXD01002316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19168:12891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..344
     V_segment       7..279
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60798.1"
                     /translation="CAREGISASGVDYW"
     D_segment       283..289
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       305..344
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           61 a          102 c          112 g           71 t
ORIGIN      
        1 acatgggggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc
       61 tggtggctcc atcagcggtt actggtgggg ctggatccgc cagtccccag ggaaggggct
      121 ggagtggatt gggtttttcg gtggtcgcaa tgggaacacc tactacaacc cctccctcaa
      181 gagtcgagtc accatttcac cagacacgtc caaagaccag ttctccctga ggctgaggtc
      241 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgagg gaggggatat cagcgtcggg
      301 ggtcgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002317             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6351:20553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002317
VERSION     KCXD01002317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6351:20553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..342
     V_segment       1..266
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <258..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60799.1"
                     /translation="CARTIFGAIVAYWHFDMW"
     D_segment       281..289
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..342
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           71 a          101 c           96 g           76 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcacctgcgt cgtctctggt gcctccatga
       61 ctggttactg gtggagctgg atccgccagc ccccagggag gggactggag tggattgggg
      121 agatcagtgg taatggtggt agcacctact acaaatcctc cctcaggagt cgagtctcca
      181 tttcaaaaga cgcgtccaag aaccagttct ccctgaaact gaactctgtg accgccgcgg
      241 acacggccga atattactgt gcgagaacca ttttcggggc gatagtggcc tactggcact
      301 tcgatatgtg gggccctggc accccaatta ccatctcctc agcc
//
LOCUS       KCXD01002318             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7659:15584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002318
VERSION     KCXD01002318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7659:15584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..439
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60800.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       450..464
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          123 c          156 g          128 t
ORIGIN      
        1 acatgggggc tctaggagag gagcccagcc ctgggattcc caggtgtttt catttgtgat
       61 cagcactgaa cacagaagac tcatcatgga gtttggcctg agctgggttt tccttgttgc
      121 tattttaaaa ggtgtccagg gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactactg
      241 gatgtactgg gttcgccaga cacctgagca ggggctggag tggatctcag ctattgatag
      301 tgctggtact agtaccacat actatgcaga ctccgtgaag ggcagattca ccatctccag
      361 agagaacgcc aagaacacac tgtatcttca gatggacagc ctgagaactg aggacacggc
      421 tgtctattac tgtgcgagag ttccgggcct agtggtattt actggttcgc ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002319             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17831:2662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002319
VERSION     KCXD01002319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17831:2662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60801.1"
                     /translation="CTGGAYANLDYW"
     D_segment       443..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          125 c          154 g          108 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctggac tgagctgttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gatggtggag tctgggggcg gcttggcaaa
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactactg
      241 gatgaactgg gtccgccaga ctccaggaaa ggggctggag tgggtctcag ctattaatta
      301 tgatgggggt agcgcatact acgcagactc cgtgaagggc cgattcacca tttccagaga
      361 caactcaaag agtacgctct ccctgcaaat gagcagcctg agagcggagg acacggccgt
      421 atattactgt acgggcgggg catacgctaa cctcgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002320             407 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16278:16130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002320
VERSION     KCXD01002320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 407)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 407)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16278:16130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    51..405
                     /note="immunoglobulin heavy chain variable region"
     V_region        51..405
     V_segment       51..344
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <336..>374
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60802.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       354..359
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       363..405
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        406..>407
                     /gene="IGHG"
BASE COUNT           91 a           90 c          125 g          101 t
ORIGIN      
        1 acatggggac ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc
       61 tggtggagtc tggaggaggc ttggttcagc ctggggggtc cctgagactc tcctgtgcag
      121 cctctggatt caccttcagt agctttggca tacactgggt ccgccaggct ccagggaagg
      181 ggctggagtg ggtggcagtt atatcgtatg atgaaactaa gaaatactac gcagactctg
      241 tgagggaccg attcaccatc tccagagaca attccaaaaa catggtatat cttcaaatga
      301 acaacctgaa attggaggac acggccgtat attactgtgc gagagatgtc aggggaacgg
      361 ggtttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002321             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12360:20626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002321
VERSION     KCXD01002321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12360:20626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..285
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60803.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       296..301
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           78 a           84 c          109 g           79 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agccgggggg gtccctgaga ctctcctgtg
       61 cagtctctgg gttcaccttc agtggctctg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga atgggtggcg gttatatcga atgatggaac taacaaatac tacgcagact
      181 ctctgaagga ccgatttagt atctccagag agaattccaa gaacatgcta tatcttcaaa
      241 tgaacaacct gaaactggag gacacggccg tctattactg cgcgacagat gcgtttggta
      301 gcgggattga ctactggggc cggggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002322             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15279:11739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002322
VERSION     KCXD01002322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15279:11739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..276
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..276
     V_segment       8..207
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <199..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60804.1"
                     /translation="CARVGGGGYYSSSLDVW"
     D_segment       218..228
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..276
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        277..>282
                     /gene="IGHG"
BASE COUNT           72 a           66 c           84 g           60 t
ORIGIN      
        1 acatgggatg gcatgcactg ggtccgccag gctccaggga aggggctgga atggatgaca
       61 cttatatcgt acgatggaag taagaaatac tacccagact ctgtgaagga ccgattcacc
      121 atctccagag acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag
      181 gacacggccg tgtactactg tgcgagagtg ggggggggtg gttattactc cagctcattg
      241 gatgtctggg gccggggagc tctggtcacc gtctccgcag cc
//
LOCUS       KCXD01002323             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16358:11036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002323
VERSION     KCXD01002323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16358:11036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..454
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60805.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       397..403
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           82 a          135 c          138 g          101 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagttcccag atgggtcctg tcccaggtgc ggctgcagga gtcgggccca
      121 ggacttgtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccttc
      181 agcggttact actggggctg gatccgccgg cccccagggg agggtctgga gtggattggg
      241 tatatcagtg ggagtggtgg gagttccgac tacaagtcct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccacttc tccctgaagc tgacctctgt gaccgccgcg
      361 gacacggccg tgtattactg tgcgagagtc cggggcgtaa ctatccacta ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002324             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20059:11304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002324
VERSION     KCXD01002324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20059:11304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60806.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       423..431
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          142 c          136 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaact acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggccg tgtattactg cgcgattggc cctagtggca
      421 gatggaacga ctggtccttc gacatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01002325             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11644:14389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002325
VERSION     KCXD01002325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11644:14389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60807.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          139 c          135 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcac tgtctctggt
      181 ggctccttca gtggttacta ctggacctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct ttatcggtgg tggtagtggg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtccaag aatcagttct ccctgaagct gacctctatg
      361 accgccgcgg acacggccgt ttatttctgt gccagagatg cgggagtggg agccacaatc
      421 ctttactact atgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002326             529 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20970:8164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002326
VERSION     KCXD01002326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 529)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 529)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20970:8164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..527
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..527
     V_segment       146..439
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <431..>496
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60808.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       449..455
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..527
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        528..>529
                     /gene="IGHG"
BASE COUNT          112 a          119 c          161 g          137 t
ORIGIN      
        1 acatggggag ctctgggaga ggagccacag ccccgggatt cccagctgtc tccacttggt
       61 catgaacact gaactcagaa gacgcaccat ggagtttgtg ctgagtttgc ttttccttgt
      121 tgctttttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 aaagcctggg gggtccctga gactctcttg tgtagtctct ggattctcct tcagtaacta
      241 tgttatgcat tgggtccgcc aggctccagg aaagggtctg gagtgggtct cacttattag
      301 tggaagtggt ggtaccacag actacgcaga ctctgtgaag ggccgattca ccctctccag
      361 agacaacgcc aaggaatcgc tttttctgca aatgaacagc ctaagagccg aggacacggc
      421 cgtgtattac tgtgctagag gcggggaaat agtggattca gagattattg aggattacta
      481 cggtttggat ttctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002327             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12262:4802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002327
VERSION     KCXD01002327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12262:4802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60809.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002328             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11095:20384
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002328
VERSION     KCXD01002328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11095:20384"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60810.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       432..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          114 c          144 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tttggcatac
      241 actgggtccg ccaggctccc gggaagggtc tggagtgggt agcagttatc tcccatgatg
      301 agaataatat atattacgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacaa cgtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtttt
      421 actgtgtgag agatacattc ggttcaggat ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002329             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:17743:13565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002329
VERSION     KCXD01002329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:17743:13565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60811.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          115 c          151 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtaca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tatttagaga
      361 caattccaag agcatcctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002330             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12520:19239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002330
VERSION     KCXD01002330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12520:19239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..286
     V_segment       8..209
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <205..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60812.1"
                     /translation="CAAGYSGNWNQWYFDLW"
     D_segment       214..234
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..286
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           71 a           78 c           81 g           58 t
ORIGIN      
        1 acatgggccg aattatccat acactgggtg cgacaggccc ctggaaaagg gcttgagtgg
       61 atgggaggtg ttgatcctgc atatggtgaa tttacacccg gagagaattt ccagggcaga
      121 gtcaccttga ccgaggacac gtctacagac acagcctaca tggaactgag cagcctgaac
      181 tctgaggaca cggccgtata ttactgtgca gccgggtata gcggcaactg gaaccagtgg
      241 tacttcgatc tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002331             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7239:6941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002331
VERSION     KCXD01002331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7239:6941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..393
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60813.1"
                     /translation="CAMILDLFDYW"
     D_segment       400..405
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           87 a          132 c          129 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggttt
      181 ctccgtcagt agtggttatg gttggacctg gatccgccag cccccaggga agggactgga
      241 atggattggg tatgtcggtg gtagtcgtga taacaccaac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaagcagttc tccctggagc tgacctctgt
      361 gaccgccgcg gacacggccg tttatttctg tgcaatgata ctggacctct ttgactactg
      421 gggccgggga gtcctggtca gcgtctcctc agcc
//
LOCUS       KCXD01002332             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16133:18995
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002332
VERSION     KCXD01002332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16133:18995"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..473
     V_segment       122..396
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60814.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       405..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          115 a          134 c          134 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cagagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctgatgcagt ccggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gttaccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa ggacttgagt ggatgggaag tgttgatcct gtatatggtg aaatgaaaga
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagtag
      361 cctgagatct gaggatacgg ccgtgtatta ttgtgcagtc ggcaatagcg gcagctggat
      421 ctcctggtcc ttcgatgtct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01002333             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20904:7641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002333
VERSION     KCXD01002333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20904:7641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60815.1"
                     /translation="CARWSDEDDHGYYYLDSW"
     D_segment       405..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          138 c          136 g          107 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtgg agccttcgga gaccctgtcc ctcacttgcg ctgtctctgg
      181 tggctccatc agcaattact actggaactg gatccgccag cccccaggaa aggggctgga
      241 gtggattggg tatatctatg gtggtagtgg gagcacaagc tacaacccct ccctcaagag
      301 tcgagtctcc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tttattactg tgcgagatgg agcgacgagg atgatcacgg
      421 ttactattac cttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002334             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5290:14741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002334
VERSION     KCXD01002334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5290:14741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60816.1"
                     /translation="CARWSAANFDYW"
     D_segment       403..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           88 a          133 c          139 g           98 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgggcaa gaacatgagg catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgat gtctcggggg
      181 gctccatcag tagtggttat ggctggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtgtctctac gatagtagtg gaaacaccta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaag ctgaggtcta
      361 tgaccgccgc ggacgcggcc gtgtatttct gtgcgagatg gtcggcagcc aactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002335             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6961:12888
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002335
VERSION     KCXD01002335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6961:12888"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60817.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          137 c          128 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc ggctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc cccctggaaa gggactggag
      241 tggattgggt atatctctgg cgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt ttattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002336             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17111:4886
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002336
VERSION     KCXD01002336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17111:4886"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60818.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          146 c          143 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caagttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgacatctg aggacacggc catctactac tgtgcgacag
      421 ggaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01002337             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17089:13511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002337
VERSION     KCXD01002337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17089:13511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60819.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       440..445
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          114 c          152 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agagcacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtatct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagtaaaat cgtttgatgg
      301 aactaagata tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtttatta
      421 ctgtgtgaga gatgcctacg ggagcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002338             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20089:6695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002338
VERSION     KCXD01002338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20089:6695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60820.1"
                     /translation="CARGRGVIIVFFDYW"
     D_segment       440..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          123 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccaatgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agttttggta aatatgacat
      241 gcattgggtc cgccaggctc cgggaaaggg cctggagtgg gtctcatcca ttagtaacgc
      301 tggtgaaacc gtcaaatacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcgctgtctc tacaaatgag cagcctgaga gccgaggaca cggccgtcta
      421 ttactgtgct agaggtcgag gggtgattat cgtcttcttt gactactggg gccggggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002339             413 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13250:3914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002339
VERSION     KCXD01002339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 413)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 413)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13250:3914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    240..411
                     /note="immunoglobulin heavy chain variable region"
     V_region        240..411
     V_segment       240..350
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <342..>380
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60821.1"
                     /translation="CGRGEYSNSIYFW"
     D_segment       354..366
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       377..411
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        412..>413
                     /gene="IGHG"
BASE COUNT           98 a           99 c          116 g          100 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 actctgtgaa ggaccgattc accatctcca gagacaattc caagaacaaa ctatatcttc
      301 aaatgaacaa cctgaaattg gaggacacgg ccctgtatta ctgtgggaga ggggaataca
      361 gtaactccat ttacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002340             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:18313:4968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002340
VERSION     KCXD01002340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:18313:4968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60822.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       439..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          120 c          146 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatcttca gtacctatgc
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtgtcag ttatttcgca
      301 tgatggaact aagaaatact acacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccgag aacaaacaat atcttcacat gaatgacctg aaattggagg acacggccat
      421 atactactgt gcggcctcct acttggggta cggatttgaa tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002341             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4090:11766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002341
VERSION     KCXD01002341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4090:11766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60823.1"
                     /translation="CARGVDNHHYSETEFDFW"
     D_segment       454..460
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          121 c          153 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtgg agtctggggg aggcttggta
      181 cagccggggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtggatatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc ggttcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gagctgagga cactgctgtg
      421 tattattgtg caagaggcgt agataaccac cactacagtg agacggagtt tgacttctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002342             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18852:11518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002342
VERSION     KCXD01002342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18852:11518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60824.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       421..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          115 a          143 c          133 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cgcagcacct
       61 caccatggac tggacctgga ggatcctcct cttagtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcag cgatttatcc atacactgga tacgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcttttggtg aaatgataaa
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcttcag acacagcctt
      361 catggaattg agcagcctga aatctgacga cacggccgtg tatttctgtg cgagtggccc
      421 tagcggcacc tggatcgact ggtccttcga tgtctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01002343             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23333:6106
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002343
VERSION     KCXD01002343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23333:6106"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60825.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       409..431
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          100 a          142 c          131 g          117 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg
      181 tggctctatc agcagtacta aatggtggaa ctggatccgc cagcccccag ggaaagggct
      241 cgagtggatt gggtatatca gtggtagtag tggtaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa cagacacgtc caacaaccag ttctccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccttttatta ttgtgcgaga tcccaatcat attgtagtgg
      421 gctttactgc ttcggctact actactttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002344             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:21831:10119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002344
VERSION     KCXD01002344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:21831:10119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60826.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          110 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002345             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12935:15632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002345
VERSION     KCXD01002345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12935:15632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60827.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          140 c          151 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccaggaca gggtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002346             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7698:10382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002346
VERSION     KCXD01002346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7698:10382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60828.1"
                     /translation="CAREYCTSDSCAGFFDYW"
     D_segment       411..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          134 c          136 g          106 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 acttggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg attcaccctc gacaactatg gaatcaactg ggtgcgacag gcccctggac
      241 aaggacttga gtggttggga gtgatcatcc cccttgtcgg tattgtgaac tacgtagaca
      301 acctccaggg cagagccacg ataaccgcgg acacgtcaac aaatacagtc tacatggaac
      361 tgaacagcct gagatctggc gacacggcca tctattactg tgcgagagag tactgtactt
      421 ctgattcttg cgccggattc tttgactact ggggccaggg agtcctggtc accgtctctt
      481 cagcc
//
LOCUS       KCXD01002347             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10510:3410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002347
VERSION     KCXD01002347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10510:3410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60829.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       444..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..513
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          120 a          121 c          151 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgt acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag tctccagggg aggggctgga atgggtggca cttatatcgt
      301 atgatggaac taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagta agcggtataa ctgaaagttc cgttgaatac ttcgagttct
      481 ggggccaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01002348             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11513:20376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002348
VERSION     KCXD01002348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11513:20376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60830.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          114 c          153 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgaaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcgtcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa attctacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaagtt ggaggacacg gccgtctatt
      421 actgtgcgag agacgtatat ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002349             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12278:10597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002349
VERSION     KCXD01002349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12278:10597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60831.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          120 c          151 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tatgatgaga ctaagaaata ctacgcagac tctgtgaagg gccgattcac catctccaga
      361 gacaattcca aaaacatgct atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002350             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7168:14727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002350
VERSION     KCXD01002350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7168:14727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60832.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          144 c          143 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg gctgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002351             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21038:3724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002351
VERSION     KCXD01002351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21038:3724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..479
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60833.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       415..422
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           89 a          140 c          140 g          112 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtagtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc agcggtggtt atggctggag ctggatccgc caggccccag ggaagggact
      241 gcagtggatt ggttttatct atggtactgg tggtagcacc tactacactc cctccctcaa
      301 gagtcgactc accatttcag cggacacgtc caagaaccag ttctccctgc atctgacctc
      361 tgtaaccgcc gcggacacgg ccgtatatta ctgtgcgaga gtttcgggca ggtgggaact
      421 atttgagcct gggtcagagg acttctgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01002352             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17985:12229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002352
VERSION     KCXD01002352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17985:12229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60834.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          109 c          158 g          128 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gatggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggac tgggtgacag ttatatcgta
      301 tgatggaagt acgaagtact atgtagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcgaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagagtag actgtagtgg tggtgtctgc tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cgtcagcc
//
LOCUS       KCXD01002353             442 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22521:12292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002353
VERSION     KCXD01002353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22521:12292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    86..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        86..440
     V_segment       86..379
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>409
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60835.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       383..389
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>442
                     /gene="IGHG"
BASE COUNT          100 a          100 c          130 g          112 t
ORIGIN      
        1 acatggggca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
       61 tgctatttta agaggtgtcc ggtgtgaggt gcaactggtg gagtctggag gaggcttggt
      121 tcaacctggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaattt
      181 tggcatacac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatttc
      241 gtctgatgga agtcacaaat actacgccaa ctctgtgaag agccgattcg ccatctccag
      301 agacaattcc aagaacatac tatatcttca aatgaacaac ttgaaattgg aggacacggc
      361 cgtctattac tgtgcgagag atgatattgg gaccggtttt gactactggg gccagggagt
      421 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002354             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:28651:9947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002354
VERSION     KCXD01002354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:28651:9947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60836.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          115 c          153 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtcctgt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctcggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgtc
      301 tgatggaagt aacatatact acgcagcctc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgttat atcttcaaat gaacaacctg aaatttgagg acacggccgt
      421 ctattactgt gcgagagatg tgtacggtag tgggttagac tactggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002355             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13090:8280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002355
VERSION     KCXD01002355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13090:8280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..443
     V_segment       92..366
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <362..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60837.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       375..389
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..443
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          105 a          119 c          133 g           88 t
ORIGIN      
        1 acatgggaga agccccagag cagagcacct caccatggac tggacctgga ggatcctcct
       61 cttggtggca gcagctacag gcgcccactc tgaggtccag ctgatgcagt ccggggctga
      121 ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag gttaccggat acaccttcac
      181 cgaattatcc atgcactggg tgcgacaggc ccctggaaaa ggacttgagt ggatgggaag
      241 tgttgatcct gtatatggtg aaatgaaaga gggcagagtc accatgaccg aggacacgtc
      301 tacagacaca gcctacatgg aactgagtag cctgagatct gaggatacgg ccgtgtatta
      361 ttgtgcagtc ggcaatagcg gcagctggat ctcctggtcc ttcgatgtct ggggccctgg
      421 caccccaatc accatctcct cagcc
//
LOCUS       KCXD01002356             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:3868:7146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002356
VERSION     KCXD01002356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:3868:7146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60838.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       407..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           93 a          135 c          136 g          113 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctgga
      181 ggctctctca gcggtggtta tgactggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg gctatatcta tggtggtact gggagcacca cctacaaccc gtccctcagg
      301 aatcgagtca ccatttcaaa agacacgtcc aagaaccagt tgtccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtatattat tgtgcgagac agtgctgtta ctatgatgac
      421 tttttagact actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002357             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13136:20983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002357
VERSION     KCXD01002357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13136:20983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60839.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          118 c          149 g          116 t
ORIGIN      
        1 acatgggggg gacaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgaactg ggtttttctt gttgctattt
      121 taagaggtgt cccgtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattccc cttcagtcac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtcata tcatacgacg
      301 aaagtaagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtttatctt cagatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01002358             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15219:19891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002358
VERSION     KCXD01002358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15219:19891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60840.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       442..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          109 c          155 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgactt gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca tgttcagtaa ctatggcatc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgtcagttat atcgtatgat
      301 gtaactgtga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca cgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tattgtgtga gagatgtcag gggaacgggg tttgacttct ggggccaggg agtcctggtc
      481 accgtctcgt cagcc
//
LOCUS       KCXD01002359             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:22160:11022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002359
VERSION     KCXD01002359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:22160:11022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..438
     V_segment       69..362
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60841.1"
                     /translation="CAREYCTTADCAGFFDSW"
     D_segment       363..373
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           93 a          109 c          135 g          103 t
ORIGIN      
        1 acatggggac catggactgg acctggaggc tcctctttgt ggtggcagca gctacaggtg
       61 tccagtccca ggtccagctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag
      121 tgaaggtttc ctgcaaggct tctggattta ccttcgacaa ctatggaatc aactgggtgc
      181 ggcaggcccc tggacaaggg cttgagtgga tgggagtggt catccccctt cttggtatta
      241 ttaattatgc agagaacttc cagggcagag taacgattaa cgcggacacg tccataagca
      301 cagccttcat ggagttcagg agcctgagat ctgacgacac ggccatttat ttctgtgcga
      361 gagaatactg tacaactgcg gattgcgccg ggttctttga ctcctggggc cagggagtca
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002360             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10967:5389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002360
VERSION     KCXD01002360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10967:5389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60842.1"
                     /translation="CATSSSGSWLYWYFDVW"
     D_segment       422..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          141 c          137 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcag cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggtg agatgattga
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggtcctg agcagcctga gatctgagga cacggccgtc tattactgtg cgacatcatc
      421 cagcggcagt tggctatact ggtacttcga tgtctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01002361             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:17649:18942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002361
VERSION     KCXD01002361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:17649:18942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60843.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       418..424
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          138 c          147 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatac tgtatctggt ggagagatat
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacggccaaa gacacagcct
      361 acatggagct gaccagcctg agatctgagg acacggccgt ttattactgt gcgagaggtg
      421 tgacggcaga cgtcttcggt ttcctcgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002362             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20152:17067
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002362
VERSION     KCXD01002362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20152:17067"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60844.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          135 c          128 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagttac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga tttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactatca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002363             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18259:7804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002363
VERSION     KCXD01002363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18259:7804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..502
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60845.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       438..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          118 c          158 g          118 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcagttg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtctc tgagactctc ctgtgtaggc tctggattca gcttcagaag ttacgaaatg
      241 agttgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagtcacact
      301 ggtgaaacca tataccacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tactgtacta gaaaccggaa tactgtaatg attgggtggt tcgatgtctg gggcccggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002364             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:7068:10691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002364
VERSION     KCXD01002364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:7068:10691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60846.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       414..423
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          143 c          136 g          100 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc ggtagttact ggtggacctg ggtccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gaaatagtgg tagtacctac tacagcccat ccctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccacctc tccctgaagc tgaattctgt
      361 gaccaccgcg gacacggccg tgtattactg tgcgaacgtc ttaggcccct ggggcagctg
      421 gtcacactac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002365             279 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9981:8262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002365
VERSION     KCXD01002365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 279)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 279)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9981:8262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..277
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..277
     V_segment       9..204
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <196..>246
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60847.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       214..234
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       236..277
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        278..>279
                     /gene="IGHG"
BASE COUNT           60 a           83 c           75 g           61 t
ORIGIN      
        1 acatgggtct ggaactggat ccgccagccc ccagggaagg gactggagtg gattgggtct
       61 atctatggtg ctactgggag caccacctac aacccctccc tcaagagtcg agtcaccatt
      121 tcaacagaca cgtccaagaa ccagttttcc ctgagactga gctctgtgac cgccgcggac
      181 accgccgtgt attactgtgc gagatatgac gacgatgatt acggttccta ttaccttgac
      241 tactggggcc agggagtcct ggtccccgtc tcgtcagcc
//
LOCUS       KCXD01002366             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10054:10682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002366
VERSION     KCXD01002366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10054:10682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60848.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          127 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc atctgcactg tctctggtga
      181 ttccatcagc aatagctact ggaactggat ccgccagccc cctgggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt actactgcgt gagatatgag gatgagtcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt ctccgtctcc tcagcc
//
LOCUS       KCXD01002367             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14585:16677
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002367
VERSION     KCXD01002367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14585:16677"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60849.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       411..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           91 a          136 c          129 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtaactt ctggatctgg atccgccagc ccccagggaa ggggctggag
      241 tggatagggt ctatctatgg tagtactggg agcacctttt acgacccctc cctcaagggt
      301 cgagtcacca tttcaacaga cacgtccaag aacctatttt ccctgaagct ggactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatata gcgatactga tagttattac
      421 ttctttgact actggggcca gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002368             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18105:7944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002368
VERSION     KCXD01002368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18105:7944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60850.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           92 a          138 c          132 g          101 t
ORIGIN      
        1 acatggggga ggttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggcgccatc agcagtggtt tctactggac ctggatccgc caacccccag ggaaggggct
      241 ggagtggatt gggtgtatcg gtggtaatag tggtaccacc tactacaacc cctccctcaa
      301 gagtcgagcc accatttcaa aagacacgtc caacaatcaa ctctccctga aggtgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002369             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:3584:15315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002369
VERSION     KCXD01002369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:3584:15315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..272
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60851.1"
                     /translation="CARWSAANFDYW"
     D_segment       277..283
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           69 a           95 c           98 g           70 t
ORIGIN      
        1 acatgggggt gaagccttcg gagaccctgt ccctcacctg cgctgtgtct ggaggctcca
       61 tcagcagtgg ttatggctgg agctggatcc gccagccccc agggaagggg ctggagtgga
      121 ttggatgtat ctatgatagc agtgggaaca cctactacaa cccctccctc aagagtcgag
      181 tcaccatttc aatagacacg tccaagaacc agttctccct gaaggtgagg tctatgaccg
      241 ccgcggacac ggccgtgtat cactgtgcga gatggtcggc agccaacttt gactactggg
      301 gtcagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002370             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11039:14051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002370
VERSION     KCXD01002370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11039:14051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60852.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       437..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          123 c          159 g          114 t
ORIGIN      
        1 acatgggggg gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcaact ggtggagtct gggggcggct tggcgaagcc
      181 tgggggatcc ctgagactct tctgtgcagc ctctggattt accttcaata cctattctat
      241 acactgggtc cgccaggctc ccgggaaggg gctggagtgg gtctcagcca ttagtagtgg
      301 tggtagaaca tactacgcag actccgtgaa gggccgagtc accatctcca gagacaactc
      361 aaagaacaca gtctccctgc aaatgaacag cctgggagct gaggacacgg ccgtgtttta
      421 ctgtgcgaga ggggagacag cttcagttta ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002371             309 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19492:3808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002371
VERSION     KCXD01002371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 309)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 309)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19492:3808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..307
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..307
     V_segment       9..232
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <226..>276
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60853.1"
                     /translation="CATGPSGTWNAWYLDMW"
     D_segment       246..256
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       258..307
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        308..>309
                     /gene="IGHG"
BASE COUNT           72 a           85 c           87 g           65 t
ORIGIN      
        1 acatgggggg tctcctgcaa ggtttccgga tacagcttca ccgaattatc catacactgg
       61 gtgcggcagg cccctggaaa agggcttgag tggatgggaa gtgttgatcc tttatatggt
      121 gaaatgaagt tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      181 atggaactga gcagcctgac atctgaggac acggccgttt attactgtgc gactggccct
      241 agcggcacct ggaacgcctg gtacctcgat atgtggggcc ctggcacccc aatcaccatc
      301 tcctcagcc
//
LOCUS       KCXD01002372             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4689:9665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002372
VERSION     KCXD01002372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4689:9665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60854.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          116 c          160 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctccgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatatcgt
      301 atgatggaag taagaaatat tacgcagaca ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002373             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18338:13947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002373
VERSION     KCXD01002373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18338:13947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60855.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       426..432
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          138 c          150 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gcaaatggtg aaataataca
      301 cgcagatggt ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagagggag
      421 gttcggtagt agcgtctggt ccaatctcgt ctatggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002374             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23144:6253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002374
VERSION     KCXD01002374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23144:6253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60856.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          121 c          146 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatgaaac taagaaattc tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002375             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:25958:16455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002375
VERSION     KCXD01002375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:25958:16455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60857.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          140 c          150 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg agacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctggaaatgg ggaaataata
      301 cacgcagata acttccaggg cagagtcacc atgaccgagg acacgtctat agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tatattactg tgcgagcggg
      421 acatttggga ccagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca gcgtctcctc agcc
//
LOCUS       KCXD01002376             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13242:9819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002376
VERSION     KCXD01002376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13242:9819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60858.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       413..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          118 a          140 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaaggag cctggggcct cagcgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaaaca
      301 cacagagttc catgccagat tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttgagc agcctaagat ctgaggacac ggccctgtat tattgtgcag tcgggtatag
      421 cggccgatgg aacaactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01002377             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9502:6508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002377
VERSION     KCXD01002377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9502:6508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60859.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          111 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagtaacg
      241 gcatgcactt ggtccgccag gttccaggga aggggctgga gtgggtggca gtgacatcgt
      301 ttgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002378             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7157:8332
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002378
VERSION     KCXD01002378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7157:8332"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..460
     V_segment       85..384
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60860.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       389..405
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..460
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           99 a          140 c          118 g          105 t
ORIGIN      
        1 acatgggggt gactcctgtg ccccaccatg gacacgcttt gctacacact cctgctactg
       61 accgtcccgt cctgggtctt gtcccaggtg accttgaagg agtctggtcc tgcgctggtg
      121 aaacccacac agaccctcac gctgacctgc accttctctg ggttctcaat cagtacttct
      181 gcaacaggtg tgggctggat ccgtcagccc ccagggaagg ccctggaatg gcttgcaagc
      241 atttattgga atgatactaa attcttcagc acttcgctga agagcagact caccgtctcc
      301 aaggacacct ccaaaaccca ggtggttcta acaatagcca acatggaccc tgtggacaca
      361 gccacatatt actgtgcacg gatacagggt ggtagttact actacggtgg gggatacttc
      421 gagttctggg gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002379             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14632:9834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002379
VERSION     KCXD01002379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14632:9834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60861.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          139 c          134 g           96 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01002380             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:6351:6460
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002380
VERSION     KCXD01002380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:6351:6460"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..486
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60862.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          102 a          135 c          138 g          113 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg cgagaacatg aagtatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagttgcagg
      121 agtcgggccc aggactgatg aagccttcag agaccctgtc cctcagctgc gctgtctctg
      181 gtggctccat aagtggtaac tggtggagct ggatccgcca gcccccaggg aagggactgg
      241 actggattgg acgtatctct ggtactagtg gggacaccaa ttacaatccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccactt ctccctgaag ctgaactctg
      361 tgaccgccgc ggacgcggcc gtgtattatt gtgcaagagc ggattacgag gatgattacg
      421 gttatcattt aggatacaac tggttcgatg tctggggccc gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01002381             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17284:6216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002381
VERSION     KCXD01002381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17284:6216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60863.1"
                     /translation="CAKGETAAVYYGLDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          132 c          150 g          109 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcagctgg tcgagtccgg gggcggcttg gcgaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tacgccattc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ctcagccatt agtagtggtg
      301 gcagcacatt ctacgcagcc tccgtgaagg gccgattcac catctccaga gacaattcaa
      361 agaacacgct ctccctacaa atgaacagcc taacaactga ggacacggcc atgtattact
      421 gtgcgaaagg agaaacagct gcagtttact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002382             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17208:11849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002382
VERSION     KCXD01002382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17208:11849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60864.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>513
                     /gene="IGHG"
BASE COUNT          117 a          151 c          143 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctccgtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgttaatgg tgacctaata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agtctcttca gcc
//
LOCUS       KCXD01002383             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:7996:8229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002383
VERSION     KCXD01002383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:7996:8229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60865.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       436..440
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          118 c          147 g          115 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg ctattttaag
      121 aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc agccgggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt ctgatggaag
      301 taagaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag acaactccaa
      361 gaacatagta tatcttcaac tgaacagcct gaaattggag gacacggccg tgtattactg
      421 tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc tgctcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002384             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18650:12155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002384
VERSION     KCXD01002384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18650:12155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60866.1"
                     /translation="CTRADITAAASFDYW"
     D_segment       425..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          117 a          143 c          122 g          101 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtgcagtc tggggctgag attcagcagc ctggggcctc aatgaagctc
      181 tcctgcaagg cttctggata taccttcact agctactaca tccactgggt gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atcgcccctt tcaatgatta caaacactat
      301 ggacagcact tccagggcag actcacctta actacggaca cgtctacgag cacagcctac
      361 atggagctga gcagcctgag atctgatgac acagccgtgt tttactgtac gagagcagat
      421 ataacagcgg ctgcctcctt tgactactgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01002385             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:15693:15086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002385
VERSION     KCXD01002385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:15693:15086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..331
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..331
     V_segment       7..254
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>300
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60867.1"
                     /translation="CAAGHSGTWIHWYFDLW"
     D_segment       270..277
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..331
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        332..>333
                     /gene="IGHG"
BASE COUNT           78 a           94 c           94 g           67 t
ORIGIN      
        1 acatgggggg cctcagtgaa ggtctcctgc aaggtttccg gatacagctt caccgaatta
       61 tccattcact gggtgcgaca ggcccctgga aaagggcttg agtggatggg aggcgttgat
      121 cctgcatatg gtgaatttac acccggagag aagttccagg gcagagtagc aatgaccgag
      181 gacacgtcta tagacacagc ctacatggaa ctgaccagcc tgaactctga ggacacggcc
      241 gtctattact gtgcagccgg gcacagcggc acctggatcc actggtactt cgatctctgg
      301 ggccctggca ccccaatcac catctcctca gcc
//
LOCUS       KCXD01002386             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5869:5017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002386
VERSION     KCXD01002386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5869:5017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..482
     V_segment       104..403
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60868.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       415..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          101 a          135 c          137 g          111 t
ORIGIN      
        1 acatggggaa tgctccctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agtcttcgga gaccctgtcc ctcacctgcg atgtctctgg
      181 ttactccatc agcagtggtt actactactg gggctggatc cgtcagcccc cagggaaggg
      241 tctggagtgg attgggtata taggtggtag tactgggacc tcctactaca accccgccct
      301 caagagtcga gttaccattt caaaagacac gtccaagaac cagttttccc tgaaggtgag
      361 ctctgtgacc gccgcggaca cggccgttta tcactgtgcg agacatggag gtttctatag
      421 tgcgactgac aagtcaacat ttgacaactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01002387             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23021:6960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002387
VERSION     KCXD01002387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23021:6960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60869.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       420..428
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          112 a          142 c          133 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaactaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aaatgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgac atctgaggac acggccgtgt attactgcgc gattggccct agtggcagat
      421 ggaacgactg gtccttcgac atctggggac ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01002388             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19768:12550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002388
VERSION     KCXD01002388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19768:12550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60870.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       455..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          105 a          124 c          158 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtcttgcca
      301 gtggtgggga tagcacatac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg catcttcaaa tggacagcct gagagttgaa gacacggctg
      421 tctattactg tgtgagagat cgacgtgttc agtcattatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002389             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4419:18796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002389
VERSION     KCXD01002389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4419:18796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60871.1"
                     /translation="CAIGPTGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          110 a          142 c          134 g           92 t
ORIGIN      
        1 acagggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggac acaccttcac cgaattgtcc attcactggg tgcgaagggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gaatatggtg aaatgaagtt
      301 ccaggccaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaactaaa
      361 cagcctgaga tctgaggaca cggccgtgta ttactgtgcg attggcccta ccggcaggtg
      421 gaacgactgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002390             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22095:10648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002390
VERSION     KCXD01002390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22095:10648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    155..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        155..324
     V_segment       155..290
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60872.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       294..300
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..324
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
BASE COUNT           86 a           71 c           89 g           78 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactgatgg aagtcacaaa tactacgcca
      181 actctgtgaa gagccgattc gccatctcca gagacaattc caagaacata ctatatcttc
      241 aaatgaacaa cttgaaattg gaggacacgg ccgtctatta ctgtgcgaga gatgatattg
      301 ggaccggttt tgactactgg ggcc
//
LOCUS       KCXD01002391             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14550:14976
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002391
VERSION     KCXD01002391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14550:14976"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60873.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          137 c          131 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcacc aatagctact ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtct atctatggtg gtactgggag caccggctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgactctga cctccgtgac
      361 cgccgcggac accgccgtgt attattgtgc gagatatgag gatgaatata gtgactacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002392             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20696:5901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002392
VERSION     KCXD01002392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20696:5901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60874.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       411..420
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           94 a          143 c          136 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggct
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcagagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcggt agttactggt ggacctgggt ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggaa atagtggtag tacctactac agcccatccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccacctctcc ctgaagctga attctgtgac
      361 caccgcggac acggccgtgt attactgtgc gaacgtctta ggcccctggg gcagctggtc
      421 acactacttt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002393             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10110:12337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002393
VERSION     KCXD01002393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10110:12337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60875.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       261..273
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       285..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           78 a           74 c           93 g           76 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gtagcctctg gattcacctt cagtaactat
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      121 tatgatgaaa ataagaaata ttatgcagac tctgtgaagg accgattcat cttctccaga
      181 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtgtattact gtgtgagaga tgactacggt agcggcctcg ggtcctgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002394             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19905:17752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002394
VERSION     KCXD01002394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19905:17752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60876.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       440..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          117 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc atctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatgtcgt
      301 ctgatggaag taacaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagagat gtctttggcg gggggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002395             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16077:6576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002395
VERSION     KCXD01002395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16077:6576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..339
     V_segment       8..269
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60877.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       275..284
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       295..339
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           76 a           87 c          101 g           77 t
ORIGIN      
        1 acatgggggt ccagcctgga gggtctctga gactctcctg tgtagcctct ggattcagct
       61 tcagaagtta cgaaatgagt tgggtccgcc aggctccggg aaaggggctg gagtgggtct
      121 catatattag tcacactggt gaaaccatat accacgctga ctccgtgaag ggccgattca
      181 ccatctccag agacaacgcc aagaattcgc tgtctctgca aatgagcagc ctgagagccg
      241 aggacacggc cgtgtattac tgtactagga accggaatac tgtaatgatt gggtggttcg
      301 atgtctgggg cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002396             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7419:23805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002396
VERSION     KCXD01002396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7419:23805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..309
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..309
     V_segment       8..251
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <243..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60878.1"
                     /translation="CARWSAANFDYW"
     D_segment       256..262
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       265..309
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        310..>311
                     /gene="IGHG"
BASE COUNT           66 a           88 c           91 g           66 t
ORIGIN      
        1 acatggggtc cctcacctgc gatgtctctg ggggctccat cagcagtggt tatggctgga
       61 gctggatccg ccagccccca gggaaggggc tggagtggat tgggtgtatc tacgatagta
      121 gtggaaacac ctactacaac ccctccctca agagtcgagt caccatttca aaagacacgt
      181 ccaagaacca gttctccctg aagatgaggt ctatgaccgc cgcggacgcg gccgtgtatt
      241 attgtgcgag atggtcggca gccaactttg actactgggg ccagggagtc ctggtcaccg
      301 tctcctcagc c
//
LOCUS       KCXD01002397             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10919:9353
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002397
VERSION     KCXD01002397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10919:9353"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..497
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60879.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       437..444
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          120 a          142 c          142 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttcgtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgtaa agtttccgga tacacggtca tcgatttatc cattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgaacatggt gaagtaatat
      301 acgcagacaa cttccagggc agagtcgcca tgagcgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcgacccacg
      421 gaggatatag aggcatctgg aactccctat actacggttt cgattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcccca gcc
//
LOCUS       KCXD01002398             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10651:12148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002398
VERSION     KCXD01002398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10651:12148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60880.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          135 g           95 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga gaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagtc tgagatctga ggacacggcc gtatattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002399             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8073:19423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002399
VERSION     KCXD01002399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8073:19423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60881.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       440..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactacgcc gactctttga aagaccgatt caccatatcc agagacgact
      361 ccaggaacat gctatatctt caactgaaca acctgaaatt ggacgacacg gccgtgtatt
      421 actgtgcgag agatgtgtat ggctgggggc ttgactactg gggccaggga gtcctagtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002400             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12974:7257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002400
VERSION     KCXD01002400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12974:7257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60882.1"
                     /translation="CAGGSRRQPDTW"
     D_segment       403..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           81 a          138 c          139 g           96 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaaga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt gggcctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atcggtggta ctagtgggag cacctactac aacccctccc tcaggagtcg
      301 agtcatcatt tcaacagaca cgtccaagaa tcacttctcc ctgaagctga cctctctgac
      361 cgccgcggac acggccgtgt attattgtgc gggcggaagt cggcggcagc cggatacctg
      421 gggccaggga gtcctggtca ccgtctcgtc agcc
//
LOCUS       KCXD01002401             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11666:7563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002401
VERSION     KCXD01002401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11666:7563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60883.1"
                     /translation="CVRDSSGSGFDYW"
     D_segment       443..448
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          113 c          148 g          122 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttctgg
      241 catacactgg gtccgcctgg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact atacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcacat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatt caagcggttc gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002402             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9134:7395
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002402
VERSION     KCXD01002402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9134:7395"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60884.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       441..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          107 a          115 c          158 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ctattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgct
      121 gttattttaa gaggtgtcca gtgtgacgtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcaggttctg gattcacctt cagtaacttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg actgggtggc tgttatgtcg
      301 tctgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa gtgaacaccc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtctttggc gggggacttg actactgggg ccagggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01002403             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18109:11238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002403
VERSION     KCXD01002403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18109:11238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..479
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60885.1"
                     /translation="CAIGPSGNWIHWSFDVW"
     D_segment       414..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>483
                     /gene="IGHG"
BASE COUNT          107 a          148 c          135 g           93 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccttctggt gcagtctggg gctgaggtga tgcagcccgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgaac tgtccatgca ctgggtgcga
      241 caggcccctg gaaaaggact tgagtgggtg ggaagtgttg atcctgcata tggtgaaatg
      301 atgttccagg gcagagtcac aatgaccgag gacacgtcta cagacacagc ctacatggag
      361 ctgagcagcc tgacacctga cgacacggcc gtctattact gtgcgattgg ccctagcggc
      421 aactggatcc actggtcctt cgatgtctgg ggccctggca ccccaatcac catctcctcg
      481 gcc
//
LOCUS       KCXD01002404             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16167:14513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002404
VERSION     KCXD01002404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16167:14513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..393
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60886.1"
                     /translation="CASLGLIEQEGVNSW"
     D_segment       417..422
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..461
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           97 a          122 c          134 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtggaag aacatgaagc acctgcggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtacaac tgcaggagtc
      121 gggcccagga gtggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctatcagc agtggttatg actggagttg gatccgccag cccccaggga aggggctaga
      241 gtggattgga tatatccatg gtagtcgtgg aatcaattat aagccgtccc tcaagaatcg
      301 agtcactatt tcaaaagacg cgtccaagaa tcagttttcc ctgaagctga gctctatgac
      361 cgccgcggac acggccgtct attactgtgc gagccttggt ttaattgaac aggagggtgt
      421 gaattcctgg ggccaagggg tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01002405             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13495:11469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002405
VERSION     KCXD01002405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13495:11469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60887.1"
                     /translation="CARDSSWYNWNQDFDYW"
     D_segment       407..420
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          101 a          137 c          132 g          101 t
ORIGIN      
        1 acatggggat gttctctgag actcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctga cccagctgca gcttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcaaatgcgc tgtctctggt
      181 ggctccatca ccggtaacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtagcactga tagtggtggg agtactgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagata gtagttggta taactggaac
      421 caagactttg actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002406             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20800:9078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002406
VERSION     KCXD01002406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20800:9078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60888.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          112 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaaac tatggcatgc
      241 actgggtccg ccaggcccca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa attctacgca gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccctgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002407             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16052:19594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002407
VERSION     KCXD01002407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16052:19594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60889.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       415..426
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          114 a          140 c          134 g          104 t
ORIGIN      
        1 acatggggac aaaacaacca catccctcct ctaaagaagc ccctgggagc acagctcatc
       61 accatggact ggacctggag gctcctcttt gtggtggcag cagctgcagg tgtccagtcc
      121 caggtccgcc tggtgcagtc cgggactgag gtgaagaagc ctggggcctc agtgaagatt
      181 tcctgcgggg cttctggttt caccctcgac acctatggta tcaactgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggagtg atcatccccc ttattggtat caccaactac
      301 gcagaaaact ctcagggcag actcacaata accgcgaaca cgtccacaaa tacagtctat
      361 atggaactga gcagtctgag atctgaggac acggccatct attactgtgc gagagaatac
      421 tgtacttcta gtacttgcgc cgggttcctt gactactggg gccagggagc cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002408             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12898:12704
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002408
VERSION     KCXD01002408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12898:12704"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60890.1"
                     /translation="CAKGDTATPYYSLDSW"
     D_segment       436..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          126 c          161 g          113 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatgcattgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagcag
      301 tggtggcaga acattctacg cagagtccgt gaggggccga ttcaccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagtctggga ggtgaggaca cggccgtgta
      421 ttactgtgcg aagggggata cagctacacc ttactacagt ttggattcct ggggccaagg
      481 ggtcgtcgtc accggctcct cagcc
//
LOCUS       KCXD01002409             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10291:17418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002409
VERSION     KCXD01002409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10291:17418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60891.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          111 a          141 c          135 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagactga catctgagga cacggccgtg tattattgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002410             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21375:15628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002410
VERSION     KCXD01002410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21375:15628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60892.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       434..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          105 a          124 c          158 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagg tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatgcaa
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtctcagcc attagtgttg
      301 gtggtagtac atattacgca ggctccgtga ggggccgatt caccatctcc agagacaact
      361 cagagaacac gctctccctg caaatgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgcgaa aggggataca gctacagttt attacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002411             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12054:7316
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002411
VERSION     KCXD01002411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12054:7316"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60893.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           93 a          137 c          129 g          101 t
ORIGIN      
        1 acatggggag gttctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tacaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtaatagtgg taccacctac tacaacccct ccctcaagag
      301 tcgagccacc atttcaaaag acacgtccaa caatcaactc tccctgaagc tgagttctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagagat gaagacccct ccatttttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002412             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12433:19311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002412
VERSION     KCXD01002412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12433:19311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60894.1"
                     /translation="CANALTGGLDYW"
     D_segment       436..444
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          106 a          120 c          158 g          107 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg tactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcagctatt gcaagtggtg
      301 gagaaaacac atactatgca gactccgtga agggccgatt caccgtctcc agagacaact
      361 caaagagcac agtctccctg caaatgaaca gtcttagaac ggaggacacg gccgtgtatt
      421 actgtgcgaa tgcgttaact ggggggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01002413             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:2678:10945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002413
VERSION     KCXD01002413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:2678:10945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60895.1"
                     /translation="CARADRGSSIDFW"
     D_segment       447..453
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          117 a          115 c          147 g          123 t
ORIGIN      
        1 acatgggggc agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagaa gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tgcaatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt
      181 tcagcctggg gggtccctaa gactctcctg tgcagtctct ggattcacct tcagtaccta
      241 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gaatgggtgg cggttatatc
      301 ttatgatgat gataagaaat actacacaga ctctttgaag gaccgattca ccatatccag
      361 agacaattcc aagaacactc tttatcttca aatgaacaac ctgaaattgg aggacacggc
      421 cgtgtattat tgtgcgagag cggatcgcgg cagttcaatt gacttctggg gccagggagt
      481 cctggtcacc gtttcctcag cc
//
LOCUS       KCXD01002414             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:3106:12615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002414
VERSION     KCXD01002414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:3106:12615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..322
     V_segment       7..253
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>291
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60896.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       268..273
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..322
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>324
                     /gene="IGHG"
BASE COUNT           73 a           81 c           97 g           73 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt tcagcctctg gattcacctt cagtagacac
       61 tggatgaact gggtccgcca ggctccagga aaggggctag agtgggtctc cggtattaat
      121 agtggtgggg atactacata ctacgcagac tccgtgaagg gccgattcac catgtccaga
      181 gacaactcaa agaacactct ctccctgcaa atgaacagcc tgagagcgga ggacacggcc
      241 gtgtattatt gtgtccaagg ggaaattttt ggagtgggtt tggattcctg gggccaaggg
      301 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002415             410 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:10610:20403
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002415
VERSION     KCXD01002415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 410)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 410)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:10610:20403"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    234..408
                     /note="immunoglobulin heavy chain variable region"
     V_region        234..408
     V_segment       234..344
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <336..>377
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60897.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       351..357
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       361..408
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        409..>410
                     /gene="IGHG"
BASE COUNT           92 a          102 c          118 g           98 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccactcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaaac tatgactctg
      241 tgaaggaccg aatcaccatc tccagagaca attccaagaa cacgcttttt cttcaaatga
      301 acaacctgaa attggaggac acggccgtgt attactgtgc gagacgccct tggaacgctg
      361 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002416             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:24527:16438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002416
VERSION     KCXD01002416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:24527:16438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..471
     V_segment       96..389
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60898.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       397..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT          102 a          128 c          140 g          103 t
ORIGIN      
        1 acatggggga gaagcccctg ggaacacagc tcatcaccat ggacttgacc tggaggctcc
       61 tctttgtggt ggcagcagct acaggtgccc agtcccaggt ccagctgatg cagtccgggg
      121 ctgaggtgaa gaagcctggg gcctcagtga agctctcctg caaggcttct ggatacacct
      181 tcagcatctt tgccatcaat tgggtgcgac aggcccctgg acaagggctt gagtggatgg
      241 gagggatcat ccctcttgtt gggataacaa actacgtgca gaagttccag ggcagagtca
      301 ccattaccgc ggacacgtcc acaagtatag cctacatgga gctgagcggc ctaagatctg
      361 aggacacggc cgtgtattac tgttcgagag ggtcaaatta cgaggatgct tccgattact
      421 tttccgcctt tgactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002417             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20584:5392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002417
VERSION     KCXD01002417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20584:5392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60899.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       435..440
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          108 a          111 c          154 g          119 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gcggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgtagcctct ggattcacct tcagtagtag tggcatgcat
      241 tgggtccgcc aggctccagg gaaggggctg gagtggctgg ctgttgaatc ccatgatgga
      301 aataagaaat actatgcaga ctccgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaacatgg tatatcttca aatgagcaac ctgaaattgg tggatacggc catgtattac
      421 tgtgtgagag atgcctacgg gggcggtttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002418             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20176:14105
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002418
VERSION     KCXD01002418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20176:14105"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60900.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          102 a          143 c          128 g          106 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctcagccga caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002419             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18431:5137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002419
VERSION     KCXD01002419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18431:5137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..469
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60901.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       419..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           94 a          139 c          129 g          109 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcttg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc ttctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggcctggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct
      181 ggtgactcca tcagcaatag ctactggaac tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtatatctc tggtgcttat gggagtacca gctacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac tgacacgtcc aagaaccagt tttccctgag gctggcttct
      361 gtgaccgccg cggacaccgc cgtttattac tgtgtgagat atgaggacga atccataaac
      421 taccactttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002420             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23226:11576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002420
VERSION     KCXD01002420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23226:11576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60902.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          109 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag tttcagtaat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttatg tcgtctgatg
      301 gaactaagaa attctacgca gactctgtga aggtccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca gcctgaaatc ggaggacacg gccgtgtatt
      421 attgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002421             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22397:8798
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002421
VERSION     KCXD01002421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22397:8798"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60903.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          136 c          131 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tcatctgcgc tgtctctggt
      181 gactccatca ccagtggctt ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatctatgg tagtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcaaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg gagatgatag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002422             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:26680:11863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002422
VERSION     KCXD01002422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:26680:11863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60904.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          141 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc actaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagtct gagatctgag gacacggccg tgtattattg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01002423             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14835:18446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002423
VERSION     KCXD01002423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14835:18446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60905.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       433..445
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          110 a          115 c          151 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcacctggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcatct tcagtagcct cggcatgcac
      241 tgggtccgcc gggctccagg gaaggggctg gagtgggtgg cagttatctc gtctgatgga
      301 agtcagaaat attatgcaga ctctatgaag gaccgattca ccatctccag agacaatgcc
      361 aagaacatgc tgtatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattac
      421 tgtgcgagag gggaatacag taactctatt gactactggg gccggggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002424             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:4864:8023
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002424
VERSION     KCXD01002424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:4864:8023"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60906.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       439..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          115 c          157 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acgcagactc tgtgaaggcc cgattcaccg tctccagaga
      361 caaatccaag aacatgttat atcttcaaat ggacaacctg aaattggaag acacggccgt
      421 ctattactgc gcgagagatg tctgggggag gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002425             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15917:19820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002425
VERSION     KCXD01002425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15917:19820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..486
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60907.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       416..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>490
                     /gene="IGHG"
BASE COUNT          118 a          139 c          132 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gctacacctt cgccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggttttgct agtatatatg gtgaaataat
      301 acatagagag agattccagg gcagagtcac catgacagcg gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgacatctga ggacacggcc gtgtattatt gtgcggcagc
      421 tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctccgcc
//
LOCUS       KCXD01002426             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:19063:14449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002426
VERSION     KCXD01002426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:19063:14449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..425
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60908.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          101 a          124 c          155 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgaagcctc cgggttcacc ttcagtgacc actgcataca
      241 ctgggtccgc caggcttcag ggaaggggct ggggtgggtc tcaggtatta cttatactgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacac
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctattt
      421 ctgtgtggca ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcgc
      481 cgtctcctca gcc
//
LOCUS       KCXD01002427             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14778:5831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002427
VERSION     KCXD01002427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14778:5831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60909.1"
                     /translation="CAKRGWGGSWNGGHYFDYW"
     D_segment       448..461
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          110 a          129 c          164 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggcgga ggcttggtcc
      181 agcctggggg gtctctgaga ctctcctgtg aagcctctgg attcactttc agtagctatg
      241 ccatgacctg ggtccgccag gctccaggga aggggctgga atggatctca tacattacta
      301 atggtggtgt taccacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcgat ggacacgctc tccctgcaaa tgaacagcct gagagctgag gacacggccg
      421 tgtattactg tgcgaaaaga ggatggggcg gcagctggaa cggggggcac tactttgact
      481 attggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002428             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16419:24553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002428
VERSION     KCXD01002428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16419:24553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60910.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          114 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg acctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002429             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8463:20530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002429
VERSION     KCXD01002429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8463:20530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..282
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..282
     V_segment       8..204
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60911.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       213..224
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       233..282
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        283..>284
                     /gene="IGHG"
BASE COUNT           59 a           83 c           83 g           59 t
ORIGIN      
        1 acatgggcta ctgggcctgg atccgccagc ccccagggaa gggactggag tggattggac
       61 gtatctctgg tagtggtggg agcaccgtct acaacccctc cctcaagagt cgagtcacca
      121 tttcaactga cacgtccaag aaccaggtct ccctgaaagt gacttctgtg accgccgcgg
      181 acacggccgt gtattactgt gcgacagccg gatatagcag cagcgaaagc ttctacggtt
      241 tggattcctg gggccaaggg gtcgtcgtca tcgtctcctc agcc
//
LOCUS       KCXD01002430             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16630:5408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002430
VERSION     KCXD01002430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16630:5408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60912.1"
                     /translation="CVRYEDEYSDYYFDHW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          134 c          131 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccatca ccaatagtta ttggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg tggtactggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt atattattgt gtgagatatg aggatgaata cagtgactac
      421 tactttgacc actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002431             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5580:7419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002431
VERSION     KCXD01002431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5580:7419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60913.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          102 a          126 c          157 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtatttccag
      301 tggtggggat agcacatact ctgcagactc cgtgaagggc agattcacca tttccagaga
      361 gaacgccaag accacactgt atcttcacat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcaagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002432             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21626:10354
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002432
VERSION     KCXD01002432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21626:10354"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60914.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          136 c          128 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgctggagtc
      121 gggcccggga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc actagttact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002433             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9342:7169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002433
VERSION     KCXD01002433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9342:7169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..497
     V_segment       116..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60915.1"
                     /translation="CARVLYYDSGYSTNPYNRFDVW"
     D_segment       416..434
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..497
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          142 c          140 g          105 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgacc agtcccaggt
      121 ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga agctctcctg
      181 caaggcttct ggatacacct tcaccatcta tgccatcact tgggtgcgac aggcccctgg
      241 acaagggctt gagtggatgg gaggaatcat ccctcttgtt ggcataacaa acgacgcaca
      301 gaagttccag ggcagagtca cgcttaccgc ggacacgtcc acaagcacag cctacatgga
      361 gctgagcagc ctgagatctg aggacacggc cgtgtattat tgtgcgagag ttttatacta
      421 tgatagtggt tattccacga acccctacaa ccggttcgat gtctggggtc cgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002434             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22868:7351
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002434
VERSION     KCXD01002434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22868:7351"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..521
     V_segment       140..432
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60916.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       447..466
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       479..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          112 a          129 c          155 g          127 t
ORIGIN      
        1 acatggggtg agagaggagc cttagccctg gatttcaagg cacttccacc tggggatcag
       61 cactgaacac agaggaccca ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcaact ggtggagtct gggggaggct tggtccagcc
      181 tggagggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gttacgacat
      241 gacctgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagttacac
      301 tggtaaaacc atatactact ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgtcaagaac tctctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttattgttct agagcggctt acgaacatga tgacggttac tattacgtcg gcaggttttt
      481 tgactgctgg ggccagggag ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002435             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18221:18567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002435
VERSION     KCXD01002435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18221:18567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60917.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          138 c          134 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgcagctga gttatgtaag
      361 tgccgcggac acggccatgt attactgtgc gagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002436             317 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24250:3742
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002436
VERSION     KCXD01002436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 317)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 317)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24250:3742"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..315
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..315
     V_segment       5..254
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <246..>284
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60918.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       263..269
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..315
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        316..>317
                     /gene="IGHG"
BASE COUNT           81 a           73 c           89 g           74 t
ORIGIN      
        1 acatggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt agttatggca
       61 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcatatg
      121 atgtaagtaa gaaatactac gcagacgctg tgaaggaccg attcaccatt tccagagaca
      181 attccaagaa cacgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      241 attactgtgg gagagatgat aatggggtgc ttatcgacta ctggggccag ggagtcctgg
      301 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002437             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11038:14642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002437
VERSION     KCXD01002437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11038:14642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60919.1"
                     /translation="CAASDSGYPFYYFDIW"
     D_segment       425..434
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          119 a          142 c          127 g          103 t
ORIGIN      
        1 acatggggga gcaacacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaccacct tcaccgaatt atccctgcac tgggtgcgac
      241 aggcccctgg aaaaggcctt gagtggatgg gaagttttaa tcctatttat ggtgaaattt
      301 tacacacaga gaagttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgatatctg aggacacggc cgtgtatttc tgtgcggcat
      421 ctgatagtgg ttatccattt tactacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002438             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14192:19851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002438
VERSION     KCXD01002438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14192:19851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..439
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60920.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       450..464
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          124 c          155 g          128 t
ORIGIN      
        1 acatgggagc tctaggagag gagcccagcc ctgggattcc caggtgtttt catttgtgat
       61 cagcactgaa cacagaagac tcatcatgga gtttggcctg agctgggttt tccttgttgc
      121 tattttaaaa ggtgtccagg gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactactg
      241 gatgtactgg gttcgccaga cacctgagcg ggggctggag tggctctcag ctattgatag
      301 tgctggtact agtaccacat actatgcaga ctccgtgaag ggcagattca ccatctccag
      361 agagaacgcc aaaaacacac tgtatcttca gatggacagc ctgagaactg aggacacggc
      421 tgtctattac tgtgcgagag ttccgggcct agtggtattt actggttcgc ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002439             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18029:8552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002439
VERSION     KCXD01002439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18029:8552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60921.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          140 c          150 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaatagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002440             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23573:19371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002440
VERSION     KCXD01002440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23573:19371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60922.1"
                     /translation="CAGGPSGIWNGWYFDIW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          115 a          144 c          136 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gttcccggat acaccttcac cgacttatcc attcactggg tgcgactggc
      241 ccctggaaaa gggcttcagt ggatcggaag tgttgatcct gcatatggtg aaatgataaa
      301 cgcagagaat ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagtta agcagcctga gatctgagga cacggccgtg tattactgtg cgggtggccc
      421 tagcggcatc tggaacggct ggtacttcga tatctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01002441             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18297:9017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002441
VERSION     KCXD01002441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18297:9017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60923.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       434..446
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          115 c          144 g          119 t
ORIGIN      
        1 acatggggga agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aaaaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact ttggcatgca
      241 ctgggtccgc cgggctccag ggaaggggct ggattgggtg gcagttatgt cgtttgatga
      301 aaatacgaaa ttctacgcag actctgtgaa ggaccgattc accatctcca gagacaactc
      361 caataacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga ggggaataca gtaactctat tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002442             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16943:8654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002442
VERSION     KCXD01002442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16943:8654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60924.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          121 a          142 c          142 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctgggacc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt atatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002443             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23236:6538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002443
VERSION     KCXD01002443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23236:6538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60925.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          138 c          139 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctggccctc acctgcgctg tctctggtgg
      181 ctccatcagt ggttactggt ggggctggat ccgccagtcc ccagggaggg ggctggaatg
      241 gattggattt ttcggtggta gtggtgggaa cacctactac aagtcctccc tccagagtcg
      301 agtcaccatt tcagccgacc cgtccaagaa ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gcgggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002444             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21453:8693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002444
VERSION     KCXD01002444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21453:8693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60926.1"
                     /translation="CARWEAADFDFW"
     D_segment       404..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           89 a          129 c          137 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgagtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gccccaggga agggactgga
      241 gtggattgtg actatgtatg gttatagtgg tagcacccac tacaacccct ccctcaagag
      301 tcgaatcacc atttcgaaag acacgtccaa gaaccaattc tccctgaagt tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gaggcagcgg actttgactt
      421 ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002445             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16881:12580
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002445
VERSION     KCXD01002445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16881:12580"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..456
     V_segment       103..396
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60927.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       403..409
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>462
                     /gene="IGHG"
BASE COUNT          105 a          106 c          136 g          115 t
ORIGIN      
        1 acatggggcc attcggtgat cagcacagaa cacagaggac tcaccatgaa gtttgggctg
       61 agctgggttt tccttgttgc tattttaaga ggtgtccagt gtgaggtaca attggtggag
      121 tctggaggag gtttggttca gcctgggggg tccctgagac tctcctgtgc agcttctgga
      181 ttcaccttca gtaactatgg catgcactgg gtccgccagg ctccagggaa ggggctggag
      241 tgggtggcag ttatatcgta tgatgtaagt aagaaatact acgcagactc tgtgcaggac
      301 cgattcacca tctccagaga caattctaag aacatgctac atcttcaaat gagcaacctg
      361 aaattggagg acacggccgt gtatttctgt gcgagacgcc cttggaacgc tgactacttt
      421 gactactggg gccagggagt cctggtcacc gtctccgcag cc
//
LOCUS       KCXD01002446             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13447:13242
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002446
VERSION     KCXD01002446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13447:13242"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60928.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       442..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          112 c          152 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcggttatat cgtttgatga
      301 tagtaagaaa tactacgtag actctgtgaa ggaccgattc accatttcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtttatta
      421 ctgtgtgaga gatgcttacg gtagtggctg ggactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002447             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13461:18410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002447
VERSION     KCXD01002447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13461:18410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60929.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       443..454
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          112 a          121 c          153 g          116 t
ORIGIN      
        1 acatgggggg agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tgctatttta agaggtgtcc attgtgaggt gcagctggtg gagtctggag gaggcttggt
      181 tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct tcactaacta
      241 tggcatgcac tgggtccgcc aggctccagg gaagggtctg gagtgggtgg cagttatgtc
      301 gcatgatgga actaagaaat tctacgcaga ctctgtgaag gaccgattca ccatctccag
      361 ggacaattcc aagaacatgg tatatcttca aatgaacaac ctgagactgg aggacgcggc
      421 cgtctattac tgtgcgagag gagactacgg taacagcctt gactactggg gccagggagt
      481 cctgctcacc gtctcctcag cc
//
LOCUS       KCXD01002448             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:4071:10695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002448
VERSION     KCXD01002448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:4071:10695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60930.1"
                     /translation="CAIGPSGRWNDWSFDIC"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          110 a          142 c          134 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtg tattattgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgtgga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002449             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10186:7751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002449
VERSION     KCXD01002449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10186:7751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60931.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          140 c          133 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggagaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagtctga gatctgagga cacggccgta tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01002450             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11327:13857
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002450
VERSION     KCXD01002450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11327:13857"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..439
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60932.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       378..393
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           86 a          132 c          127 g           96 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc ttctcctggt ggctgctccc
       61 agatgggtcc tgtcccagct gcatctgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacctg cgctgtctct ggtggctcca tcagcaatag ctactggaac
      181 tggatccgcc agcccccagg gaaggggctg gagtggattg ggtctatcta tggtggtact
      241 gggagcgccg gctacaaccc ctccctcaag agtcgagtca ccgtttcaac agacacgtcc
      301 aagaaccagt tttccctgaa gctgacgtct gcgaccgccg cggacaccgc cgtgtattac
      361 tgtgcgagat atgaggatga atacagtgac taccactttg actactgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002451             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9469:18251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002451
VERSION     KCXD01002451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9469:18251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60933.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          111 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacatagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg cgcgagagac gattttggca gcggcttagg gtactggggc cagggagccc
      481 tggtgaccgt ctcctcagcc
//
LOCUS       KCXD01002452             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:7025:9172
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002452
VERSION     KCXD01002452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:7025:9172"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60934.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          121 a          146 c          142 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caagttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgacatctg aggacacggc catctactac tgtgcgacag
      421 gaaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01002453             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5781:11163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002453
VERSION     KCXD01002453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5781:11163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..500
     V_segment       142..434
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60935.1"
                     /translation="CARARGVIITYFDYW"
     D_segment       442..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          102 a          124 c          160 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgacctggg tccgccaggc tccagggaag gggctggaat ggatctcagg tattagcagt
      301 ggtggggata gcacatccta tgcagactcc gtgaagggca gattcaccat ctcccgagag
      361 gacgccaaga acacactgta tcttcagatg gacagtctga gagttgagga cacggctgtc
      421 tattactgtg cgagggcgcg cggggtgatt attacatact ttgactactg gggccaggga
      481 gtcctggcca ccgtctcctc ggcc
//
LOCUS       KCXD01002454             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21239:18435
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002454
VERSION     KCXD01002454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21239:18435"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..493
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60936.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>500
                     /gene="IGHG"
BASE COUNT          116 a          116 c          153 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agcagctttg
      241 gcttacactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatggaag taacaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta taccttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg cgcgacagat gcgtttggta gcggaattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcaacagcc
//
LOCUS       KCXD01002455             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19714:3448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002455
VERSION     KCXD01002455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19714:3448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60937.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          114 a          145 c          137 g           96 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agtacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgacttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac atacacagcc
      361 tacatggagc tgagcagcct gtcatctgag gacacggccg tgtatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01002456             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20496:6900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002456
VERSION     KCXD01002456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20496:6900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60938.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       423..435
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          138 c          149 g           97 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagta aaggtctcct
      181 gccaggtttc cggatacacc ttcagtgaaa tgtccatgca ctgggtgcga caggcccctg
      241 gaaaagggct tgagtggatg ggatgtgttg ctcctggaaa tggtgaaata atacacgcag
      301 agaacttcca gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg
      361 agctgagtag cctgagatct gaggacacgg ccgtatatta ctgtgcgaca gggaggttcg
      421 ggagcagcgt ctggtccagc ctcttctacg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002457             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7234:6292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002457
VERSION     KCXD01002457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7234:6292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60939.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          129 c          155 g          121 t
ORIGIN      
        1 ccatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt gccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc aacctctgga ttcagtttca gttactacta
      241 catgggctgg gtccgccagg ctccagggaa gggtctggaa tggatctcag gtattaacag
      301 tggtggggat accacatact atgcggactc cctgaatggc agattcacca tctccagaga
      361 caacgccaag aacacactgt ctcttcaaat ggacggcctg agagctgagg actcggcagt
      421 ctattactgt gcgcgagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002458             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12259:12241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002458
VERSION     KCXD01002458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12259:12241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60940.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       431..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          148 c          147 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgtc aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggatggga gttgttgatc ctgtcaatgg tgaagaaatt
      301 cacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggtg gcagcggctg gtccaacctc ttcaccggtt tggaatcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002459             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10061:8833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002459
VERSION     KCXD01002459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10061:8833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60941.1"
                     /translation="CAREFSPYDYFWSDFYSYYFDYL"
     D_segment       431..436
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           96 a          145 c          133 g          115 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 gactccttca gcggttacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc atatcagtgg gagtagtggg agcaccgact acaacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag agccacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagt tttcccccta cgactatttt
      421 tggagtgatt tttactctta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01002460             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20166:16870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002460
VERSION     KCXD01002460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20166:16870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60942.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           99 a          148 c          132 g          107 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc aactggtaca gtctggacca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg ataccgcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ccggtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01002461             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21218:11829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002461
VERSION     KCXD01002461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21218:11829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60943.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       439..445
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          119 c          155 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 caaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gaagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcaggt tcaattatta ctacatgagc
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattag tagtggtggg
      301 gaaagcacat actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaacacac tatatcttca aatggacagc ctgagaactg aggacacggc tgtctatttc
      421 tgtgtgagag atcgacgtgt acagtcgtta tcctggttcg atgtctgggg cccgggagcc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002462             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8691:7300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002462
VERSION     KCXD01002462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8691:7300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..429
     V_segment       75..368
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60944.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       372..384
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       388..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           94 a           95 c          131 g          111 t
ORIGIN      
        1 acatgggggg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
       61 gaggtgtcca gtgtgaggtg cagttggcgg agtctggagg aggcttggtt cagcctgggg
      121 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt ggcatgcact
      181 gggtccgtca ggctccagga aaggggctgg agtgggtggc agttatctcg tctgatggaa
      241 gttacaaata ctacgaagac tctttgaagg accgattcac catctccaga gacaattcca
      301 ggaacatgca atatcttcag atgaacaacc tgaaattgga ggacacggcc gtgtatttct
      361 gtgcgagagg ggaatacagt aactctattg acttctgggg ccagggagtc ctggtcaccg
      421 tctcgtcagc c
//
LOCUS       KCXD01002463             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5327:16848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002463
VERSION     KCXD01002463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5327:16848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..495
     V_segment       125..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60945.1"
                     /translation="CAIGGWWGDYPPSDWFDVW"
     D_segment       428..439
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT           95 a          146 c          147 g          111 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gtgcttcctt ttctgtcctc
       61 caccacgatg gggtcaactg ccatcctcac cctcctactg gctgttctcc aaggagtctg
      121 tgccgaggtg cagctggtgc agtctggagc agaggtgaaa aggcccgggg agtctctgaa
      181 gatctcctgt aagacttctg gagacacctt aagctactat tggatcagct gggtgcgcca
      241 gatgcccggg aaaggcctgg agtggatggg ggcgattgat cctggtgatt ctgataccaa
      301 atacagcccg tccttccaag gccaggtcac catctcagcc gacaagtcca tcaacaccgc
      361 ctacctgcag tggaccagcc tgaaggcctc ggacaccgcc acgtattttt gtgcgatagg
      421 ggggtggtgg ggtgattatc caccctcaga ctggttcgat gtctggggcc cgggagtcct
      481 ggtcaccgtc tcctcggcc
//
LOCUS       KCXD01002464             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18882:16749
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002464
VERSION     KCXD01002464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18882:16749"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60946.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          146 c          142 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tctacttctg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01002465             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10745:13759
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002465
VERSION     KCXD01002465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10745:13759"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60947.1"
                     /translation="CARDGRGSGTDVW"
     D_segment       439..443
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          109 c          159 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cgtcagtagt tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 gaaatacgag attctacgca gactctgtga aggaccgatt caccatctcc agcgacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag agatgggcgg ggttcaggca cggatgtctg gggtcgggga gttctagtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002466             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19350:16400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002466
VERSION     KCXD01002466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19350:16400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60948.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       445..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          103 a          122 c          160 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcactc gacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccaat gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactatta
      241 catgacctgg gtccgccagc ctccagggaa ggggctggag tggatctcgg gtattgacag
      301 tggggggggt agtgcatact atccagactc cgtgaagggc agattcatca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agacctgaag acacggctgt
      421 ctattactgt gcgagagtcg tgggtggtag tgctggatac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002467             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15506:10881
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002467
VERSION     KCXD01002467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15506:10881"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60949.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       431..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          113 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggaacc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt attgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtagc tatggcttgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtctgatg
      301 aagataggaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag ggatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002468             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16455:11805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002468
VERSION     KCXD01002468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16455:11805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..488
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60950.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       422..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>491
                     /gene="IGHG"
BASE COUNT          119 a          145 c          131 g           96 t
ORIGIN      
        1 acatgggaca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga ttcaccttca ccgatttatc catacactgg atacgacagg
      241 cccctggaaa agggcttcag tggatgggaa gtgttgatcc tgcatatggt gaaatgataa
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggaatt gagcagcctg aaatctgacg acacggccgt atattactgt gcgagtggcc
      421 ctagcggcac ctggatcgac tggtccttcg atgtctgggg ccctggcacc ccaatcaccg
      481 tctcctcaac c
//
LOCUS       KCXD01002469             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16362:19311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002469
VERSION     KCXD01002469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16362:19311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..484
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60951.1"
                     /translation="CASGPSGSWNEWYFDIW"
     D_segment       418..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>487
                     /gene="IGHG"
BASE COUNT          115 a          141 c          138 g           93 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga actatccatg cactgggtgc gacaggcccc
      241 tggaaaagga cttcagtgga tgggaagtgt tgatcctgca tttggtgaaa tgatcaacgc
      301 agagaagttc cagggcagag tcaccttgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgatc agcctgagat ctgaggacac ggccgtgtat tactgtgcga gtggccctag
      421 cggcagctgg aacgagtggt atttcgatat ctggggccct ggcaccccaa tcaccgtctc
      481 ctcaacc
//
LOCUS       KCXD01002470             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8231:15223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002470
VERSION     KCXD01002470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8231:15223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60952.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       449..456
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          111 a          116 c          162 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggta caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg agtgggtggc actgatatcg
      301 tttgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcac cctctccaga
      361 gacaattccg agaacatcct atatcttcaa atggacaacc tgaaattgga ggacacggcc
      421 gtgtattttt gtgcgagagt tggagagggt actggtggtg cggaggactt tgacttctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002471             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16781:6957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002471
VERSION     KCXD01002471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16781:6957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..444
     V_segment       90..380
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60953.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       386..392
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          103 a          107 c          129 g          107 t
ORIGIN      
        1 acatgggcag cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc
       61 ttgttgctat tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct
      121 tggttcagcc tggggggtcc ctgagactct cctgtgcagc ctctggattc atcttcagta
      181 actatgccat gcactgggtc cgccaggctc cagggaaggg gctagagtgg gtggcagtta
      241 tttcgcatga tggaactaag aaatactaca cagactctgc gaaggaccga ttcaccatct
      301 ccagagacaa ttccaagaac atacaatatc ttcacatgaa cagcctgaaa ttggaggaca
      361 cggccatata ctactgtgcg gcctcctact tggggtacgg ttttgagtac tggggccagg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002472             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4532:14032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002472
VERSION     KCXD01002472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4532:14032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60954.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          112 a          123 c          154 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcaca aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtga agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc aattattact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaatc
      301 atggtgggga aagtacatac tatgcagact ccgtgaaggg cagattcacc ctctccagag
      361 agaacgccaa gaacacacta tatcttcaaa tggacagcct gagaactgag gacacggctg
      421 tctattactg tgtgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002473             274 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18295:3074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002473
VERSION     KCXD01002473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 274)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 274)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18295:3074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..272
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..272
     V_segment       8..211
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <203..>241
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60955.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       220..226
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       233..272
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        273..>274
                     /gene="IGHG"
BASE COUNT           70 a           61 c           81 g           62 t
ORIGIN      
        1 acatgggagt tttggcatgc actgggtccg ccaggctcca gggcaggggc tggagtgggt
       61 ggcagttata tcgtatgatg taagtaagaa atactacgca gacgctgtga aggaccgatt
      121 caccatctcc agagacaatt ccaagaacac gctatatctt caaatgaaca acctgaaatt
      181 ggaggacacg gccgtgtatt actgtgggag agatgataat ggggtgctta tcgacttctg
      241 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002474             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10378:4890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002474
VERSION     KCXD01002474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10378:4890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..500
     V_segment       125..414
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60956.1"
                     /translation="CVRERGEDGGAGIPHYFDYW"
     D_segment       439..446
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          144 c          142 g          101 t
ORIGIN      
        1 acatggggga tcacataaca accacgtccc tcctctaaag aagcccctgg gaacacagct
       61 catcaccatg gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca
      121 gtcccaggtc cagctggtgc agtccggggc tgaggtgaag acgcctgggg cctcagtgaa
      181 actctcctgc aagacttctg gatacagctt cagcatctat gccatccatt gggtgcgtca
      241 ggcccctgga caaggccttg agtggatggg acggatcgtc cctcttgttg gtatgacaaa
      301 ctacgcacag aagttccagg acagagtcac acttaccgcg gacacgtcca caaggacagc
      361 ctacatggaa ctgagcagcc tgagatctga cgacacggcc ttctattatt gtgtacgaga
      421 gaggggcgaa gatgggggag ctggaatccc ccactacttt gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002475             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11681:10637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002475
VERSION     KCXD01002475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11681:10637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60957.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       433..440
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          119 a          141 c          138 g          101 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt taagaagcct ggggcctcag tgagggtctc
      181 ctgccaggtt tccggataca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt tgatcctgta aatggtgaaa taatacacgc
      301 agacaacttc cagggcagag tcaccatgac cgaagacacg tctatagaca cagcctacat
      361 ggaactgagc agcctgagat ctgaggatac ggccgtatat tactgtgcga cccacggagg
      421 ctatagtgac atctggaact ccctgtacta cggtttggat tcctggggcc aaggggtctt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002476             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11522:3977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002476
VERSION     KCXD01002476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11522:3977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60958.1"
                     /translation="CANALTGGLDYW"
     D_segment       441..449
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          123 c          159 g          110 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 caccactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaggtactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctattgcaag
      301 tggtggagaa agcacatact atgcagactc cgtgaagggc cgattcaccg tctccagaga
      361 caactcaaag aacacagtct ccctgcaaat gaacagtctt agcgcggagg acacggccgt
      421 gtattactgt gcgaatgcgt taactggggg tcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002477             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18389:17636
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002477
VERSION     KCXD01002477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18389:17636"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60959.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          116 c          151 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggccgg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtttatctt cagatgaaca acctgaagtt ggacgacacg gccgtctatt
      421 actgtgcgag agacgcattt ggcagcggct gtgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002478             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22397:11074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002478
VERSION     KCXD01002478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22397:11074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60960.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       294..301
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       305..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           80 a           83 c          104 g           83 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcagcttc agtaactctg gcattcactg ggtccgccag gctccagggg
      121 aggggctgga gtgggtggca gttatatcgt atgatgaaac taagacatac tacgcagact
      181 ctgtgaagga ccgattcacc atttccagag acaattccaa gaacatggta catcttcaaa
      241 tgaacaccct gaatttggag gacacggccg tatattactg tgtgagagat tcttacggta
      301 gaggctttga ccagtggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002479             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23741:7473
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002479
VERSION     KCXD01002479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23741:7473"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..512
     V_segment       145..435
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60961.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       451..458
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..512
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>516
                     /gene="IGHG"
BASE COUNT          122 a          142 c          145 g          107 t
ORIGIN      
        1 acatggggag atctgtcctt gtccagagag catcacacaa caaccacatc cctcccctac
       61 agaagcccca gagcacagca cctcaccatg gactggacct ggaggatcct cctcttggtg
      121 gcagtagcta caggcgccca ctctgaggtc cagctggtgc agtctggggc tgaagtgaag
      181 aagcctgggg cctcagtgaa ggtctcctgc aaggtttccg gatacaggtt caccgaatta
      241 tccatacact gggtgcgaca ggcccctgga aaagggcttg agtggttggg aagtgttgat
      301 tatcaatatg atgaaataat gcacgcagac aaattccagg gcagagtcac catgaccgag
      361 gacacgtcca cagacacagc ctacatggag ctgagcagcc tgagatctga ggacacggcc
      421 gtgtattact gtgcggcggg ccttggggga tatttacttc ttactgaata tttccagttc
      481 tggggccagg gcgccctggt caccgtctcc tccgcc
//
LOCUS       KCXD01002480             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:8354:10961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002480
VERSION     KCXD01002480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:8354:10961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    70..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        70..439
     V_segment       70..363
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <355..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60962.1"
                     /translation="CAREYCTSSACAGFFDSW"
     D_segment       364..375
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           98 a          126 c          124 g           93 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctttg tggtggcagc agctgcaggt
       61 gtccagtccc aggtccgcct ggtgcagtcc ggggctgatg tgaagaagcc tggggcctca
      121 gtgaaggttt cctgcggggc ttctggattc accctcgact cctatggaat caactggata
      181 cgacaggccc ctggacaagg gcttgagtgg atgggagtga ccatccccct tattggtatc
      241 acgaactacg caaggacgtc tcagggcaga gtcacaataa ccgcgaacac gtccacaaac
      301 acagcctaca tggagctgag cagcctgaaa tctgaggaca cggccatcta ttactgtgcg
      361 agagaatact gtacttccag tgcttgcgcc gggttctttg attcctgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002481             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:26923:9613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002481
VERSION     KCXD01002481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:26923:9613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60963.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          118 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcaacacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttata
      241 gcacgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaac taagaaatac tacgtagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tcaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01002482             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14485:16129
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002482
VERSION     KCXD01002482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14485:16129"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60964.1"
                     /translation="CARDEDPSIFDHW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           89 a          136 c          131 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcttc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 cgccatcagc aggggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtagtagtgg taccacctat tataacccct ccctcaagag
      301 tcgagcctcc atttcaaaag acacgtccaa caatcaactc tccctgaagc tgagttctgt
      361 gaccgtcgcg gacacggccg tgtattactg tgcgagagat gaagacccct ccatttttga
      421 ccactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002483             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14345:17038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002483
VERSION     KCXD01002483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14345:17038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..429
     V_segment       63..354
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60965.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       362..368
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       381..429
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           95 a          112 c          129 g           95 t
ORIGIN      
        1 acatggggga ctggacctgg aggatcctcc tcttggtgac agcagctgca ggcgcccgct
       61 ctgaggttca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      121 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      181 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      241 acgcagaaaa gttccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      301 acatggagct gatcagcctg agatctgaag acacggccgt gtattactgt gcgacatcac
      361 ccagcggcaa ttggcttttt tggtacttcg atttttgggg ccctggcacc ccaatcacca
      421 tctcctcagc c
//
LOCUS       KCXD01002484             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21393:3842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002484
VERSION     KCXD01002484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21393:3842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60966.1"
                     /translation="CAGGSRRQPENW"
     D_segment       398..402
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           82 a          132 c          139 g          101 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctatgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atcggtggta ctagtgggag tacctactac aatccctccc tcgagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa tctcttctcc ctgaagatga gttctttaac
      361 cgccgcggac acggccatgt atttctgtgc gggcggaagt cggcgtcagc cggagaactg
      421 gggccaggga gtcctggtca ccgtctcttc agcc
//
LOCUS       KCXD01002485             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17649:10354
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002485
VERSION     KCXD01002485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17649:10354"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60967.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          131 c          137 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccaggg ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact ggagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atccatggga gtgatagtag taccaagtac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa tcaatgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 tattgactac tggggccagg gagtcctggt caccatctcc tcagcc
//
LOCUS       KCXD01002486             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:13836:10628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002486
VERSION     KCXD01002486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:13836:10628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..491
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60968.1"
                     /translation="CARYFNYEDDYGHSYTGGIDAFDFW"
     D_segment       402..433
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT           94 a          142 c          141 g          116 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaggc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggc ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctcaggtgg
      181 ctccatcagc agtagcttct ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtct atctatggtg ggagtgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cttccgagaa ccagtgttcc ctgaacctga actctgtgac
      361 cgccgcggac tccgccgtgt attactgtgc gagatacttc aattacgagg atgattacgg
      421 tcactcttac accggtggta ttgatgcttt tgatttctgg ggccaaggac tcagggtcac
      481 cgtctcttca gcc
//
LOCUS       KCXD01002487             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8158:20119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002487
VERSION     KCXD01002487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8158:20119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..296
     V_segment       10..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60969.1"
                     /translation="CARDVYGTGLDYW"
     D_segment       241..246
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           75 a           66 c           85 g           72 t
ORIGIN      
        1 acatggggta gcctctggat tcagtttcag tggctttggc atgcactggg tccgccaggc
       61 tccagggaag ggactggagt gggtggcagt tatctcgtat gatgaaacta agaaatatta
      121 cgcagacttt gtgaaggacc gattcaccgt ctccagagac aatgccaaga atatgctata
      181 tattcaaatg aacaacctga aattggaaga cacggccgtg tattactgtg cgagagatgt
      241 ctatggcacg ggacttgact actggggcct gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002488             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18487:8775
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002488
VERSION     KCXD01002488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18487:8775"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60970.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          113 c          154 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaggatgcta tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002489             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:25182:6478
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002489
VERSION     KCXD01002489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:25182:6478"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..324
     V_segment       6..257
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60971.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       258..262
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..324
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        325..>326
                     /gene="IGHG"
BASE COUNT           73 a           85 c           99 g           69 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgcg cagcctctgg attcaacttc aattactact
       61 acatgaactg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaca
      121 gtggtgggga tagcacatac tatgcggact ccgtgaaggg cagattcacc atctccagag
      181 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg
      241 tctattactg tgcgagagtg gtgggtggtg ccgcaggata cttcgacttc tggggccagg
      301 gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002490             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11569:7368
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002490
VERSION     KCXD01002490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11569:7368"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60972.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          116 c          154 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtga aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcgtccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaattc tacgcagact ctgagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gtatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002491             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23868:8778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002491
VERSION     KCXD01002491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23868:8778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60973.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          115 c          152 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcttgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtaatttcg
      301 aatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga
      361 gacaattcca tgaacatgct atttcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002492             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17377:10925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002492
VERSION     KCXD01002492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17377:10925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60974.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       400..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           92 a          138 c          140 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctctggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatgag cagtcactac tgcagctgga tccgccagtc cccagggaag ggactggagt
      241 ggattggacg gatctctggt agtggtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcaccct ctcaacagac acgtccaaga aggagatctc cctgaagctg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagagaaga ctatggtggt aattattact
      421 ttaaccggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002493             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10073:9307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002493
VERSION     KCXD01002493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10073:9307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60975.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       439..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          120 c          158 g          119 t
ORIGIN      
        1 acatggggtg agagaggagc cttagccctg gatttcaagg cacttccacc tggggatcag
       61 cactgaacac agaggaccca ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggaggct tggtccagcc
      181 tggagggtct ctgagactct cctgtgtagc ctctggattc agcttcagaa gttacgaaat
      241 gagttgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagtcacac
      301 tggtgaaacc atataccacg ctgcctccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact aggaaccgga atactgtaat gattgggtgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002494             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15071:9176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002494
VERSION     KCXD01002494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15071:9176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60976.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       402..416
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          136 c          134 g          106 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggcg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg atatattagt attagtggga ggaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaagttg acctctgtga
      361 ccgtcgcgga cacggccgtg tattactgtg cgagatatcc atatagtggg agctacttca
      421 ggtactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002495             414 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15498:5326
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002495
VERSION     KCXD01002495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 414)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 414)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15498:5326"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    40..412
                     /note="immunoglobulin heavy chain variable region"
     V_region        40..412
     V_segment       40..332
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <325..>381
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60977.1"
                     /translation="CASGPTAIFGMLVTGLDFW"
     D_segment       351..357
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       371..412
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        413..>414
                     /gene="IGHG"
BASE COUNT           92 a          108 c          119 g           95 t
ORIGIN      
        1 acatgggtct tggtggcagc aactacaggc gcccactctg aggtccagct ggtgcagtct
       61 gggtctgagg tgaagaagcc tggggcctca gtgaaggtct cctgcaaggt ttccggatac
      121 accttcaccg aattctccat gcactgggtg cgacaggccc ctggaaaagg gcttgagtgg
      181 atgggagctg ttgatccttt atctaatgaa ataatatacg cagacaactt ccagggcaga
      241 gtcaccatga ccgaggacac gtctacagac acagcctaca tgcaactgag cagcctgacc
      301 tctgaggaca cggccattta ttactgtgcg agtgggccta ctgcaatttt tggaatgctt
      361 gttacggggc ttgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002496             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22272:3508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002496
VERSION     KCXD01002496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22272:3508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    151..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        151..514
     V_segment       151..442
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60978.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       459..469
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT           98 a          157 c          139 g          122 t
ORIGIN      
        1 acatgggggt ctccctcacc acccagctgg ggatctcagt gcttcatttt ctgtccttca
       61 tttctcagtg cttcatttct gtcctccacc acgatggggt caactgccat cctcgccctc
      121 ctcctggctg ttctccaagg agtctgtgcc gaggtgcagc tggtgcagtc tggagcagag
      181 gtgaaaaggc ccggggaatc tctgaggatc tcctgtaaga cttctggata cagctttacc
      241 gattactgga tcagttgggt gcgccagatg cccgggaaag gcctggagtg gatgggaatg
      301 atctatccta gtgattctga tcccagatac agcccgtcct tccaaggcca ggtcaccatc
      361 tcagccgaca ggtccatcag caccgcctac ctggagtggg gcagcctgaa ggcctcggac
      421 accgccacgt attactgtgc gagagctgga cgctacacct acagttaccc ctttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002497             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19092:11203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002497
VERSION     KCXD01002497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19092:11203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..359
     V_segment       9..289
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <281..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60979.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       292..307
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       311..359
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           73 a           95 c          112 g           81 t
ORIGIN      
        1 acatggggtg gtggagtctg ggggcggctt ggcaaagcct gggggatccc tgagactctc
       61 ctgtgcagcc tctggattca ccttcagtac ctatgctatg cactgggtcc gccaggctcc
      121 agggaagggg ctggagtggg tctcagccat tagtgttggt ggtagtacat actacgcaga
      181 ctccgtgagg ggccgattca ccatctccag agacaactca gagagcacgc tctccctgca
      241 aatgaacagc ctgagtactg aggacacggc cgtgtattac tgtgccaaag gggatacagc
      301 tacagtttat tacggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc
      361 c
//
LOCUS       KCXD01002498             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:6862:3381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002498
VERSION     KCXD01002498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:6862:3381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60980.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          121 c          143 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggc tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag tgtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002499             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21997:9649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002499
VERSION     KCXD01002499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21997:9649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60981.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       448..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          122 c          156 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtcttg ccagtggtgg
      301 ggatagcaca tactatgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagtt gaagacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcatt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002500             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23110:9681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002500
VERSION     KCXD01002500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23110:9681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60982.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          112 c          156 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgcgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagtaacg
      241 gcatgcactg ggtccgccag gttccaggga aggggctgga gtgggtggca gtgacatcgt
      301 ttgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002501             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12980:10535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002501
VERSION     KCXD01002501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12980:10535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60983.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          143 c          143 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtccacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggcttg gattcttggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002502             526 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10405:17394
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002502
VERSION     KCXD01002502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 526)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 526)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10405:17394"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    170..524
                     /note="immunoglobulin heavy chain variable region"
     V_region        170..524
     V_segment       170..449
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <443..>493
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60984.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       463..473
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..524
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        525..>526
                     /gene="IGHG"
BASE COUNT          119 a          156 c          147 g          104 t
ORIGIN      
        1 acatggggga ctggtgtctg ccgaggtaaa tacagatctg tccttgtcca gagagcatca
       61 cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca ccatggactg
      121 gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg aagtccagct
      181 ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgagggtct cctgcaggat
      241 ttccggatac accttcaccg aattatccat acactgggtg cggcaggccc ctggaaaagg
      301 gcttgagtgg atgggaagtg ttgatcctct gtatggtgaa atgaagttcc agggcagagt
      361 caccatgacc gaggacacgt ctacagacac agcctacttg gaactgagcg gcctgacttc
      421 tgaggacacg gccgtgtatt actgtgcgac tggccctacc ggcacctgga acgcctggta
      481 cctcgatatc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01002503             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24353:11836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002503
VERSION     KCXD01002503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24353:11836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60985.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          148 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagcgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcttgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccac gctccaggga agggactgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaactccct gagattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002504             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10832:11526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002504
VERSION     KCXD01002504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10832:11526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..520
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60986.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       446..465
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..520
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          113 a          130 c          154 g          125 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttacgacatg
      241 acctgggtcc gccaggctcc gggaaagggg ctggaatggg tctcatatat tagttacact
      301 ggtaaaacca tatactactc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaact ctctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgttcta gagcggctta cgaacatgat gacggttact attacgtcgg caggtttttt
      481 gactgctggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002505             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18448:17850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002505
VERSION     KCXD01002505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18448:17850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60987.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          124 c          149 g          107 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatggcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgcttcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtatct ggttatttta tgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002506             423 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22362:13850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002506
VERSION     KCXD01002506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 423)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 423)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22362:13850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    43..417
                     /note="immunoglobulin heavy chain variable region"
     V_region        43..417
     V_segment       43..350
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <343..>390
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60988.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       357..366
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       378..417
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        418..>423
                     /gene="IGHG"
BASE COUNT           69 a          124 c          128 g          102 t
ORIGIN      
        1 acatggggac tgtgggtctc tctgttcaca ggggtcctgt cccagctgca cctgcaggag
       61 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      121 ggctctatca gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggag
      181 tggattgggt gtatctttgg tggtggtatc tttggtggtg gaagtaacac cttctacagc
      241 ccttccctca agagtcgagt caccctgtca gtggacgcgt ccaagaccca gctctccctg
      301 aagctgacgt ctgtgaccgc cgcggacacg gccgtgtatt tctgtgcgag cgctgatagt
      361 ggttatcctc cctacttctt tgacatctgg ggccagggag tcctggtcac cgtctcccca
      421 gcc
//
LOCUS       KCXD01002507             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:26728:7864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002507
VERSION     KCXD01002507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:26728:7864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..321
     V_segment       8..234
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <228..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60989.1"
                     /translation="CATGRIGASGWSNLFNGLYSW"
     D_segment       253..263
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..321
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           74 a           84 c           95 g           70 t
ORIGIN      
        1 acatggggca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
       61 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgagctaata
      121 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      181 tacatggagt tgagcagcct gacatctgag ggacggccat ctacttctgt gcgacaggga
      241 ggatcggtgc cagtggctgg tccaacctct tcaatggttt gtattcctgg ggccaagggg
      301 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01002508             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13516:15309
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002508
VERSION     KCXD01002508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13516:15309"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60990.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       433..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          113 c          151 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccggtgtga ggtgcaactg gtggagtctg gagggggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctttggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ttcatctgat
      301 ggaagtaaca aatactacgc aaactctgtg aaggaccgat ttaccatctc cagagacaat
      361 tccaagaaca tagtatatct tcaaatgaac aacctgaaat cggaggacac ggccgtctat
      421 tactgtgcga gagatgatat ggggaccggt tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002509             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14086:7978
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002509
VERSION     KCXD01002509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14086:7978"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60991.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       422..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          112 a          141 c          139 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgatag
      301 acgcagaaaa gttccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagcctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcaa ttggcttttt tggtacttcg atttttgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002510             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:13895:14145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002510
VERSION     KCXD01002510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:13895:14145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60992.1"
                     /translation="CAKRGWGGSWNGGHYFDYW"
     D_segment       442..455
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          109 a          127 c          163 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg cggaggcttg gtccagcctg
      181 gggggtctct gagactctcc tgtgaagcct ctggattcac tttcagtagc tatgccatga
      241 cctgggtccg ccaggctcca gggaaggggc tggaatggat ctcatacatt actaatggtg
      301 gtgttaccac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 cgatggacac gctctccctg caaatgaaca gcctgagagc tgaggacacg gccgtgtatt
      421 actgtgcgaa aagaggatgg ggcggcagct ggaacggggg gcactacttt gactattggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002511             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16465:9107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002511
VERSION     KCXD01002511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16465:9107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60993.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          113 a          143 c          133 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aagatttccg gatacacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagtagcctg acatctgagg acacggccgt gtattactgt gcgactggcc ctagcggcac
      421 ctggaacgcc tggtacctcg atatctgggg ccctggcacc tcaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01002512             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21623:14539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002512
VERSION     KCXD01002512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21623:14539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60994.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          120 a          144 c          144 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctgggg cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 acacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcca cagacacagc
      361 cttcatggag ttgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaacct cttctacggc ttggattctt ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002513             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13242:19921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002513
VERSION     KCXD01002513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13242:19921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..301
                     /gene="IGHV2-173"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <294..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60995.1"
                     /translation="CARRLWGRFDSW"
     D_segment       308..314
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       318..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           85 a          102 c           93 g           82 t
ORIGIN      
        1 acatgggggt gaccttgaag gagtctggtc ctacgctggt gaaacccaca cagaccctca
       61 cgctgacctg taccttctct gggttctcaa tcagttctac tgatacgggt gtgagctgga
      121 tccgtcagcc cccagggaag gccctggaat ggcttgcaac cgtttattgg gataatgata
      181 agttcttcgg cacatctctg aagaacagac tcaccatctc caaggacacc tccaaaaacc
      241 aggtggttct cacaatgacc aacatggacc ctgtggacac agccacatat tactgtgcac
      301 gacgactctg gggaaggttt gactcctggg gccagggagt cctggtcagt gtctcctcag
      361 cc
//
LOCUS       KCXD01002514             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18297:16419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002514
VERSION     KCXD01002514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18297:16419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60996.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       449..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          114 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggtga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcgt
      301 ttgatgatag taagaaatac tactcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcttacggta gtggctggga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002515             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15836:4013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002515
VERSION     KCXD01002515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15836:4013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60997.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          114 a          140 c          135 g           99 t
ORIGIN      
        1 atggggatca cacaacagcc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctgcaggc gcccgctctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcgaggt ttccggatat accttcaccg aactgtccat tcattgggtg cgacaggccc
      241 ctggaaaagg ccttgagtgg atgggaagtg ttgatcctga atatggtgaa atgataaacg
      301 cagaaaaatt ccagggcaga gtcaccttga ccgaggacac gtctacagga acggcctaca
      361 tggacctgat cagtctgaga tctgaagaca cggccgtgta ttactgtgcg acatcaccca
      421 gcggcacctg gctatattgg tacttcgatt tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01002516             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10285:13988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002516
VERSION     KCXD01002516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10285:13988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60998.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          113 c          151 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcattc
      241 actgggtccg ccaggctcca gggaagaggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtgtatctt caaatgaaca acctgaaatt ggaggacacg gccatatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002517             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17699:14651
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002517
VERSION     KCXD01002517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17699:14651"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX60999.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       420..426
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          113 a          140 c          144 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctcc agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat actgtatctg atggagtgat
      301 atacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgcgagagg
      421 tgtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002518             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14560:5510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002518
VERSION     KCXD01002518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14560:5510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61000.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           97 a          135 c          131 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgaccc tcacatgcgg tgtctctggt
      181 ggctccatca ccaatagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg tggtactggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctcagtg
      361 accgccgcgg acaccgccgt ttattattgt gcgagatatg aggatgaata cagtgactac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002519             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17230:17500
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002519
VERSION     KCXD01002519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17230:17500"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..484
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61001.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>488
                     /gene="IGHG"
BASE COUNT          117 a          141 c          131 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccggc tacagcttcg ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gttttgctag tatatatggt caaataatac
      301 atacagagag attccagggc agagtcacca tgacagcgga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta cccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctccgcc
//
LOCUS       KCXD01002520             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23490:14526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002520
VERSION     KCXD01002520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23490:14526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61002.1"
                     /translation="CARYEADGASYYFDYW"
     D_segment       404..408
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           86 a          140 c          132 g          112 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg tcctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccagggg cagctgcagg
      121 agtcgggccc aggactggtg aagccctcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtgactccgt cgtcaatagc ttctggagct ggttccgcct gcctctaggg aaggggctgg
      241 agtggattgg ctatatctat ggtgcgactg ggagcaccac ctacaacccc tccctcaaga
      301 gtcgagccac catttccaca gacacgtcca agaatcagtt ttccctgaag ctgacctctg
      361 tgaccgccgc ggacaccgcc gtgtatttct gtgcgagata tgaagctgat ggtgcttctt
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002521             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21338:14747
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002521
VERSION     KCXD01002521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21338:14747"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61003.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tgtattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01002522             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:24131:3227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002522
VERSION     KCXD01002522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:24131:3227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..463
     V_segment       83..374
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61004.1"
                     /translation="CGTGVYYQDEYGNFYVGGDFDYW"
     D_segment       383..403
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>469
                     /gene="IGHG"
BASE COUNT          103 a          123 c          139 g          104 t
ORIGIN      
        1 acatggggga acacagctca tcaccatgga cttgacctgg aggctcctct ttgtggtggc
       61 agcagctaca ggtgcccagt cccaggtcca cctggtgcag tccggggctg aggtgaagaa
      121 gcctggggcc tcagtgaagc tctcctgcaa ggcttctgga tacaccttca gcatctcttc
      181 catcagttgg gtgcgacagg cccctggaca agggcttggg tggataggag ggatcatccc
      241 tcttgttggt atgacaaact acggacagaa gttccagggc agagtcacaa ttaccgcgga
      301 cacgtccacg aatacagtct tcatggaact gagcagcctg acatctgagg acacggccgt
      361 ctactattgt gggacagggg tatattacca ggatgaatac ggtaattttt atgtcggcgg
      421 tgactttgac tactggggcc agggagtcct ggtcaccgtc tccccagcc
//
LOCUS       KCXD01002523             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21984:18128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002523
VERSION     KCXD01002523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21984:18128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..330
     V_segment       6..257
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61005.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       268..280
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           72 a           86 c           98 g           76 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccctc agtaactact
       61 ggatgtattg ggttcgccag gcaccaggga aggggctgga gtggatctca ggcataaata
      121 gtgttgggag tagtacatac catgcagact ccgtgaaggg cagattcacc atctccagag
      181 agaacgccca gaacacactg tttcttcaaa tggacagcct gagacctgag gacacggctg
      241 tctattactg tgcgagagtt ccgggcctag tggtgtttac cggttcgctt gactactggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002524             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9803:2801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002524
VERSION     KCXD01002524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9803:2801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61006.1"
                     /translation="CARSSSGSWINWYFDIW"
     D_segment       423..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          123 a          142 c          136 g           90 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga cacaccttca ccgagctatc catccactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtatatggt gaaataagga
      301 acacagacaa cttccagggc agagtcacca tgaccgagga cacgtcaaca gacacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattattgt gcgagatcat
      421 ccagcggcag ctggataaac tggtacttcg atatctgggg cccaggcacc ccagtcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002525             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10776:10711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002525
VERSION     KCXD01002525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10776:10711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..475
     V_segment       124..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61007.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       407..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          115 a          135 c          135 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcagagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctgatgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggttaccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttga gtggatggga agtgttgatc ctgtatatgg tgaaatgaaa
      301 gagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagt
      361 agcctgagat ctgaggatac ggccgtgtat tattgtgcag tcggcaatag cggcagctgg
      421 atctcctggt ccttcgatgt ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01002526             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18083:13656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002526
VERSION     KCXD01002526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18083:13656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..287
     V_segment       6..199
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <191..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61008.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       204..225
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       237..287
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           65 a           79 c           81 g           64 t
ORIGIN      
        1 atgggggagc tggatccgcc agcccccagg gaagggactg gactggattg gacgtatctc
       61 tggtactagt ggggacacca attacaatcc ctccctcaag agtcgagtca ccatttcaac
      121 agacacgtcc aagaaccact tctccctgaa gctgaactct gtgaccgccg cggacgcggc
      181 cgtgtattat tgtgcaagag cggattacga ggatgattac ggttatcatt taggatacaa
      241 ctggttcgat gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002527             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17362:11954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002527
VERSION     KCXD01002527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17362:11954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61009.1"
                     /translation="CAREYCTTTDCAGFFDFW"
     D_segment       408..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          129 c          142 g          105 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctttcctgca
      181 aggcttctgg attcaccttc gacaactatg gaatcaactg ggtgcggcag gcccctggac
      241 aagggcttga gtggatggga gtgaccatcc cccttgttgg tattgtaaat tatgcagaga
      301 agttccaggg cagagtcacg attaacgcgg acacgtccac aaacacagcc ttcatggagg
      361 tgaggagcct gagatctgag gacacggcca tttatttctg tgcgagagaa tactgtacaa
      421 ctacagattg cgccggcttc tttgacttct ggggccaggg agccatggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01002528             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15542:12884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002528
VERSION     KCXD01002528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15542:12884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61010.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          118 a          115 c          149 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gggttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc aatacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatgaaac taaaaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tggacaacct gaaattggag gactcggccg
      421 tgtattactg tgtgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01002529             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16684:15265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002529
VERSION     KCXD01002529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16684:15265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..494
     V_segment       104..397
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61011.1"
                     /translation="CARDAGYGDTISVVDINMFPHFDYW"
     D_segment       415..438
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          102 a          136 c          141 g          117 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgtg ttgtctctac
      181 tgcctccatc agtagttact ggtggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gtaatagtgg tagtttttac tacaaccctt ccctcaacag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagagat gccgggtatg gggatacgat
      421 atcagtagtc gatattaata tgttccccca ctttgactac tggggccagg gagtcctggt
      481 cgccgtctcc tcagcc
//
LOCUS       KCXD01002530             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:18857:19834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002530
VERSION     KCXD01002530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:18857:19834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61012.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       443..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          122 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcaccttc actacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 ttgatgaaac taaggaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgtgagagat tcttacggcc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002531             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22630:20698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002531
VERSION     KCXD01002531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22630:20698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61013.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          116 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctactttaag agatgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccaa gaacatgcta tatcttcaat tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002532             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8856:6769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002532
VERSION     KCXD01002532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8856:6769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61014.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          141 c          148 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgagatccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgccag gtgtccggat acacgttcag tgaaatctcc atgcactggg tgcgacagac
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agtagcctga gatctgacga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002533             384 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23044:20345
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002533
VERSION     KCXD01002533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 384)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 384)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23044:20345"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    19..382
                     /note="immunoglobulin heavy chain variable region"
     V_region        19..382
     V_segment       19..312
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <304..>351
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61015.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       322..328
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       338..382
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        383..>384
                     /gene="IGHG"
BASE COUNT           83 a           91 c          123 g           87 t
ORIGIN      
        1 acatggggtg tccagtgtga ggtgaagctg gtggagtctg ggggcggctt ggcaaagcct
       61 ggggggtccc tgagactctc ctgcgcagcc tctggattca gcttcaatta ttactacatg
      121 agctgggtcc gccaggctcc agggaagggg ctggagtgga tctcaggtat taatagtggt
      181 ggggaaagca catactctgc agactccgtg aagggcagat tcaccatctc cagagagaac
      241 gccaagaaca cgctatatct tgaaatggac agcctgagaa ctgaggacac ggctgtctat
      301 tattgtgtga gagatcgacg tgtacagtcg ttatcctggt tcgatgtctg gggcccggga
      361 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002534             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24699:10008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002534
VERSION     KCXD01002534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24699:10008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61016.1"
                     /translation="CARHGGSYYSKW"
     D_segment       399..413
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           91 a          129 c          130 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcatc agtaactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctatggta gtggtagtag caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagata cgtccaagaa ccagttctcc ctgaagttga attctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagacatggt ggtagttatt actcgaagtg
      421 gggccaggga gtcctggtca tcgtctcctc agcc
//
LOCUS       KCXD01002535             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15941:9332
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002535
VERSION     KCXD01002535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15941:9332"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61017.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       411..420
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           94 a          144 c          136 g           98 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggct
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cctcagagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcggt agttactggt ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggaa atagcggtag tacctactac agcccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccaccactcc ctgaagctga actctgtgac
      361 caccgcggac acggccgtgt atttctgtgc gaacgtctta ggcccctggg gcagctggtc
      421 acactacttt gagtactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002536             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15171:10816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002536
VERSION     KCXD01002536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15171:10816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61018.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       428..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          147 c          146 g           96 t
ORIGIN      
        1 actgggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tttggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggag ttgttgatcc tgccaatggt gaagaaatac
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtag cagcgcctgg tccaacctct tcaccggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002537             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15015:15863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002537
VERSION     KCXD01002537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15015:15863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61019.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          104 a          127 c          156 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttaatggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggcgt ggatctcagg tattaacgct
      301 ggtggggata ccacatacta tgcagactcc gtgaagggca gatccaccat ctccagagag
      361 aacgccagga acacactgca tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002538             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15834:2971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002538
VERSION     KCXD01002538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15834:2971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61020.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       437..444
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          118 a          116 c          147 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtccaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagcaac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaagtaagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaaat ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg aatgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01002539             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16718:13106
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002539
VERSION     KCXD01002539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16718:13106"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61021.1"
                     /translation="CARMWYWPIPDVW"
     D_segment       403..409
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..458
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           84 a          131 c          141 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaggc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 ctccatcagc ggtggttatg gctggaactg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtctctttg gcagtagtgg aagaacctac tacaatccgt ccctcaagag
      301 tcgagtcgct atttcaaaag acacgtccaa gaaccagttc tccctgatcc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaatg tggtactggc cgatccccga
      421 tgtctggggc ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002540             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14005:9710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002540
VERSION     KCXD01002540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14005:9710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61022.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       416..424
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          111 a          141 c          132 g           91 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca actacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaaat gatgcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attgtccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgacgttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag
      361 cctgacatct gaggacacgg ccgtgtatta ctgcgcgatt ggccctagtg gcagatggaa
      421 cgactggtcc ttcgacatct ggggacctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01002541             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8679:3757
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002541
VERSION     KCXD01002541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8679:3757"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..429
     V_segment       63..356
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61023.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       367..381
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       388..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           91 a          104 c          134 g          102 t
ORIGIN      
        1 acatggggga gtttggcctg agctgggttt tccttgttgc tattttaaaa ggtgtccagg
       61 gtgaggtgca gctggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
      121 tctcctgtgc agcctctgga ttcaccatca gtaactactg gatgtactgg gttcgccagg
      181 caccagggaa ggggctggag tggatctcag ccattaatag tgctgaaagt accacatact
      241 atgcagacgc cgtgaagggc agattcacca tctccagaga caacgccaag aacacactgt
      301 atcttcaaat ggacagcctg agagctgagg acacggctgt ctattactgt gcgagagtac
      361 cgggcctagt ggtgtttact ggttcccttg actactgggg ccagggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01002542             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22236:15837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002542
VERSION     KCXD01002542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22236:15837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61024.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       446..451
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          108 a          118 c          158 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagacactg
      241 gatgaactgg gtccgccagc ctccaggaaa ggggcttgag tgggtctcaa ctattaatag
      301 tggtggggat aacacatatt acgcggactc cgtgaagggc cgattcacca tctccagaga
      361 caattcaaag aacacgctcc tcctgcaaat gaacagcctg agagtggagg acacggccgt
      421 gtattactgt gttcaagggg aaatttttgg agtgggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002543             406 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15346:12931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002543
VERSION     KCXD01002543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 406)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 406)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15346:12931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    50..404
                     /note="immunoglobulin heavy chain variable region"
     V_region        50..404
     V_segment       50..343
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <335..>373
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61025.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       353..358
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       359..404
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        405..>406
                     /gene="IGHG"
BASE COUNT           86 a           92 c          124 g          104 t
ORIGIN      
        1 acatgggagc tgggttttcc ttgttgctat tttaagaggt gtccagtgtg aggtgcagct
       61 ggtggagtct ggaggaggct tggttcagcc tggggggtcc ctgagactct cctgtgcagc
      121 ctctggattc accttcagta tctctggcat gcactgggtc cgccaggctc cagggaaggg
      181 gctggagtgg gtggcagtta aatcgtttga tggaaccaag atatactacg cagactctgt
      241 gaaggaccga ttcaccattt ccagagacaa ttccaagaac atgctatatc ttcaaatgaa
      301 caacctgaaa ttggaggaca cggccgttta ttactgtgtg agagatgcct acgggagcgg
      361 tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002544             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11232:11297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002544
VERSION     KCXD01002544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11232:11297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61026.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          104 a          126 c          157 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gtctctggat tcagtttcag tcactacttc
      241 atgagctggg tccgccagac tccagggaag ggactggagt ggatctcagt gattaacagt
      301 ggtggagata ccacacacta tgcagactcc gtgaagggca gattcaccat gtccagagag
      361 aacgccagga acacactgtc tcttcaaatg gacggcctga gacctgagga ctcggctgtc
      421 tattactgtg cgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002545             379 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14782:14716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002545
VERSION     KCXD01002545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 379)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 379)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14782:14716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    23..377
                     /note="immunoglobulin heavy chain variable region"
     V_region        23..377
     V_segment       23..316
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <308..>346
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61027.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       317..322
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       332..377
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        378..>379
                     /gene="IGHG"
BASE COUNT           87 a          100 c          111 g           81 t
ORIGIN      
        1 acatggggca ggcgcccact ccgaggtcca gttggtacag tctggggttg aggtgaagaa
       61 gcctggggcc tccgtgaaaa tctcctgcca ggcttctgga tacaccttaa ccgaccacta
      121 cctgcactgg gtgcgacagg ctcctggaga aggacttgag tggatgggag gtgttcatcc
      181 tgaatttggt aaagtagact acacacagaa gttccaagac agagtcacca tcaccgcgga
      241 catgtcgaca gagacagtct acatggagct gagcagcctg agatctgagg acacggccgt
      301 ttattactgt gtgacagtgg gtccctacca ttactttgac ttctggggcc agggagccct
      361 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002546             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16372:11659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002546
VERSION     KCXD01002546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16372:11659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61028.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           94 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagg tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01002547             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21595:10681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002547
VERSION     KCXD01002547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21595:10681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61029.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       442..456
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          122 c          154 g          119 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac catcagtaac tactggatgt
      241 actgggttcg ccaggcacca gggaaggggc tggagtggat ctcagccatt aatagtgctg
      301 aaagtaccac atactatgca gacgccgtga agggcagatt caccatctcc agagacaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag agtaccgggc ctagtggtgt ttactggttc ccttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002548             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13317:17474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002548
VERSION     KCXD01002548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13317:17474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..519
     V_segment       141..440
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61030.1"
                     /translation="CAREAYSWNNLYFYGLDSW"
     D_segment       447..461
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..519
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          113 a          125 c          162 g          121 t
ORIGIN      
        1 acatggggct gggagaagag accccgcctg ggattcccag gagtttccac ctggtgatca
       61 gcactgaaca caaaccacca gccatggagt ttgggctgag ctgggttttc cttgttgcta
      121 tttggaaagg tgtccagtgt gaggtgcagc tggtggagtc cgggggaggc ttggtccagc
      181 ctggcgggtc cctgagcctc tcctgtgcag cctctggatt caccttcagt gattctggta
      241 tggactgggt ccgccaggct ccaggaaagg ggctggagtg ggtaggtttc attagaagca
      301 aaacttatgg tgggacagca gaatactccg cgtctgtgaa gggcagattc accatctcca
      361 gagatgattc aaagaacacg gcgtatctgc agatgaccag cctgaaaacc gaggacacgg
      421 ccgtatatta ctgtgctaga gaggcgtata gttggaacaa cctatatttc tacggtttgg
      481 attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01002549             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9062:3165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002549
VERSION     KCXD01002549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9062:3165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61031.1"
                     /translation="CARMWYWPTPDVW"
     D_segment       403..409
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..458
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           84 a          132 c          140 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaggc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 ctccatcagc ggtggttatt gctggaactg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtctctttg gcagtagtgg aagaacctac tacaatccgt ccctcaagag
      301 tcgagtcgct atttcaaaag acacgtccaa gaaccagttc tccctgatcc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaatg tggtactggc cgacccccga
      421 tgtctggggc ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002550             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8327:18483
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002550
VERSION     KCXD01002550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8327:18483"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..286
     V_segment       8..224
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61032.1"
                     /translation="CATADYGNSLDYW"
     D_segment       230..241
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..286
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>289
                     /gene="IGHG"
BASE COUNT           76 a           71 c           75 g           67 t
ORIGIN      
        1 acatggggga ttcaccttca gtacttttgg catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggcag ttatatcgtc tgatggaagt atgaaatact acgcagactc
      121 tatgaaggac cgattcacca tctccagaga caattccaag aacatactat atcttcaaat
      181 gaagaacctg aaattggagg acactgccgt ctattattgt gcgacagccg actacggtaa
      241 cagccttgac tactggggcc agggagtcct ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01002551             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14024:6686
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002551
VERSION     KCXD01002551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14024:6686"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61033.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          139 c          128 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgcg gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc cccccgggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagtactgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtccta gtcaccgtct cctcagcc
//
LOCUS       KCXD01002552             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8484:16439
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002552
VERSION     KCXD01002552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8484:16439"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..474
     V_segment       108..404
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61034.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       409..422
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           93 a          133 c          144 g          106 t
ORIGIN      
        1 acatgggggg gaaatgctct ctgagagtca tggacctcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcagctgc
      121 aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcact tgcgttgtct
      181 ctggccactc catcagcagt ggctaccact ggggctggat ccgtcagccc ccagggaagg
      241 gactggacta tattggctat atcagtggta gtagtgggag cacctactac aagccctccc
      301 tcatgagtcg agtcatcatt tcaagagaca cgtcccggaa tgagttctcc ctgaggctga
      361 ggtctgtgac tgtcgcggac acggccgtgt attattgtgc gagacgagat agctggaaca
      421 acggggggag ccttgactac tggggccagg gattcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002553             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:27412:17443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002553
VERSION     KCXD01002553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:27412:17443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..478
     V_segment       118..407
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <400..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61035.1"
                     /translation="CVKSGSASLHWYLEIW"
     D_segment       409..416
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          101 a          128 c          145 g          106 t
ORIGIN      
        1 acatggggga agtccacagt gttccattcg gtgatcagca ctgaacacag aggactcacc
       61 atggagtctg ggctgagctg ggttttcctt gttgctattt taagaggtgt ccagtgtgag
      121 gtgcagctgg tggagtctgg gggcggcttg gcggaacccg ggggatccct gagactctcc
      181 tgtgcagcct ctggattcac cttcagtacc tatgctatgc actgggtccg ccaggctcca
      241 gggaaggggc tggagtgggt ctcagctatt agtagtggtg gaaccacatc ctacgcagac
      301 tccgtgaagg gccgattcac cgtctccaga gacaactcaa aaaacacgct gtccctgcag
      361 atgaacagcc tgagagctga ggacacggcc gtgtattact gtgtgaagag tgggagtgcc
      421 agccttcact ggtacctcga aatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002554             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17510:16988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002554
VERSION     KCXD01002554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17510:16988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61036.1"
                     /translation="CARVDCSGGVCYFDFW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          109 a          115 c          157 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc atctggtggg gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtggct cttatatcgt
      301 atgatggaag taagacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatgttcaaa tgaacaacct ggaattggag gacacggccg
      421 tgtattactg tgcgagagta gactgtagtg gtggtgtctg ctactttgac ttctggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002555             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21158:6864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002555
VERSION     KCXD01002555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21158:6864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61037.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          119 a          145 c          128 g           90 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct gaatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtattca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccga gacagaatca ccatcaccgc ggacatgtcg acagagacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cacttattac tgtgtgacag
      421 tgggtcccta ccattacttt gactactggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01002556             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18265:16125
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002556
VERSION     KCXD01002556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18265:16125"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..508
     V_segment       133..426
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <418..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61038.1"
                     /translation="CTRVKYYYDSGYYVGPFDSW"
     D_segment       433..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          107 a          126 c          144 g          133 t
ORIGIN      
        1 acatggggga gccacagccc cgggattccc agctgtctcc acttggtcat gaacactgaa
       61 ctcagaagac gcaccatgga gtttgtgctg agtttggttt tccttgttgc tattttaaaa
      121 ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggtgaa gcctgggggg
      181 tccctgagac tctcttgtat agcctctggg ttctccttca gtacctatcc tttgcactgg
      241 gtccgccagg ctcccggaaa gggtctggag tgggtttcag ttattagtga aactggtgga
      301 accacatact acgcagactc tgtgaagggc cgattcacca tctccagaga caacgccaag
      361 aactcactgt ttctgcaaat gaccagcctg agagccgagg acacggccgt ctattattgt
      421 actagagtca aatattacta tgatagtggt tattacgtcg ggccatttga ctcctggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002557             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23045:18968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002557
VERSION     KCXD01002557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23045:18968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..448
     V_segment       94..390
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61039.1"
                     /translation="CARWEAADFDYW"
     D_segment       397..403
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           86 a          129 c          136 g           99 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgt aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcggtggtt atggctggag ttggatccgc caggccccag ggaagggact ggagtggatt
      241 gggactatgt atggtcatag tggtagtacc cgctacaatc cctccctcaa gagtcgagtc
      301 accatttcaa aagacacgtc caagaaccac ttttccctga cgctgagctc tctgaccgcc
      361 tcggacacgg ccgtgtatta ctgtgcgaga tgggaggcag cggactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002558             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7691:14251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002558
VERSION     KCXD01002558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7691:14251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61040.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       417..423
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          139 c          143 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctccaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatact gtatctgatg gagtgatata
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg cgagaggtgt
      421 gacagcagac gtcttcggtt tcctcgggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002559             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20863:6243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002559
VERSION     KCXD01002559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20863:6243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61041.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          110 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggctttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagctt ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg cctgactcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt cagatgaaca acctgaaatt gaaggacacg gccgtgtact
      421 actgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002560             312 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16221:16846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002560
VERSION     KCXD01002560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 312)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 312)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16221:16846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..310
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..310
     V_segment       8..240
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <232..>279
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61042.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       260..267
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       268..310
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        311..>312
                     /gene="IGHG"
BASE COUNT           67 a           91 c           82 g           72 t
ORIGIN      
        1 acatgggcct gcgctgtctc tggtgactcc atcagcaata gctactggaa ctggatccgc
       61 cagcccccag ggaaggggct ggagtggatt gggtatatct ctggtgctta tgggagtacc
      121 agctacaacc cctccctcaa gagtcgagtc accatttcaa ctgacacgtc caagaaccag
      181 ttttccctga ggctggcttc tgtgaccgcc gcggacaccg ccgtttatta ctgtgtgaga
      241 tatgaggacg aatccataaa ctaccacttt gactactggg gccagggagt cctggtcacc
      301 gtctcctcag cc
//
LOCUS       KCXD01002561             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16685:15128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002561
VERSION     KCXD01002561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16685:15128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61043.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       434..439
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          109 a          112 c          152 g          118 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca atgtgaggtg cagctggtgg agtctggagg cggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gtagcctctg gattcacctt cagtagtagt ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtggctggc tgttgaatcg catgatggaa
      301 ataagaaata ctatgcagac tccgtgaagg accgattcac catctccaga gacaattcca
      361 agcacatggt atatcttcaa atgaacaacc tgaaattggt ggatacggcc atgtattact
      421 gtgtgagaga tgcctacggg ggcggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01002562             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22624:5838
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002562
VERSION     KCXD01002562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22624:5838"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61044.1"
                     /translation="CARYEADGASYYFDYW"
     D_segment       402..406
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           86 a          140 c          130 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggtc ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcacctgcgg tgtctctggt
      181 gactccgtcg tcaatagctt ctggagctgg ttccgcctgc ctctagggaa gggactggag
      241 tggattggct atatctatgg tgcgactggg agcaccacct acaacccctc cctcaagagt
      301 cgagccacca tttccacaga cacgtccaag aatcagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg aagctgatgg tgcttcttac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002563             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20917:6778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002563
VERSION     KCXD01002563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20917:6778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..497
     V_segment       140..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61045.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       438..443
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..497
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          112 c          153 g          118 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagaccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acgttcagta actatggaat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tatcgtacga
      301 tgaagataag aaatactacg cagactctct gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atgctttatc ttcaaatgaa caacctgaaa ttggaggaca cggccgttta
      421 ttactgtgcg aggaggccct ggagtgcaga tgcttttgat ttctggggcc aaggactcag
      481 ggtcaccgtc tcttcagcc
//
LOCUS       KCXD01002564             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19466:12159
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002564
VERSION     KCXD01002564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19466:12159"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61046.1"
                     /translation="CARADIEAAASFDFW"
     D_segment       426..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          124 a          132 c          126 g          101 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tggggctgag attaagcagc ctggggcctc agtgaaactc
      181 tcctgcaagg cttctggata tatcttcatg gactactaca tgcactgggt gaaacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt ataatggtta caaaggatat
      301 gcacagaact tccaggacag agtcaccata accacggaca cgtccacgag cacaggctac
      361 atggagctga gaagcctgaa atatgaggac acaggcgttt attactgtgc gagagcagat
      421 attgaagcgg ctgcctcctt tgacttctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01002565             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:13453:12981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002565
VERSION     KCXD01002565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:13453:12981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..466
     V_segment       94..390
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <382..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61047.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       396..415
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..466
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           91 a          136 c          136 g          105 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg tggctccatc
      181 agcagtagta cctggtggaa ctgggtccgc cagcccccag ggaaaggcct ggagtggata
      241 ggatatatca atggtgagag tggtagcacc tactacaatc cctccctcga gagtcgaatc
      301 accatttcaa cagacacgtc cacgaaccag ttttccctga ggctgagctc tgtgaccgcc
      361 gcggacacgg ccgtgtattt ctgtgcgaga ggttcctata gtggtagtta ttacttcaac
      421 cggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002566             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10823:11446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002566
VERSION     KCXD01002566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10823:11446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61048.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          114 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactttg
      241 gcttacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatggaaa taagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatggta tatcttgaaa tggacaacct gcaattggag gacacggccg
      421 tgtatttctg tgtgagagat gcctacggta ccgggttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002567             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17177:10563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002567
VERSION     KCXD01002567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17177:10563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61049.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       448..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          113 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctga attcacgttc agtaattttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatctcga
      301 atgatgccac taagaaatac tacgtggact ctgtgaagga ccgattcacc atctccagag
      361 acaactctaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcgtttggca gcgggcttga ttactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002568             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13754:13836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002568
VERSION     KCXD01002568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13754:13836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..497
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61050.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       417..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          112 a          137 c          146 g          108 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccacctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacc ttcagcatct ctgccatcag ttgggtgcga caggcccctg
      241 gacaagggct tgggtggatg ggagggatca tccctcttgt tggtatgaca aactacgaac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacgaataca gtcttcatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtctacta ttgtgcgaca ggggtatatt
      421 accaggatga aaacggttat ttttatgtcg gcggtgactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01002569             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18415:4910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002569
VERSION     KCXD01002569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18415:4910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61051.1"
                     /translation="CATGPSGTWNAWYLDMW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          112 a          142 c          135 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aaggtttccg gatacagctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctttatatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt ttattactgt gcgactggcc ctagcggcac
      421 ctggaacgcc tggtacctcg atatgtgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01002570             342 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24259:12373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002570
VERSION     KCXD01002570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 342)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 342)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24259:12373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..340
     V_segment       8..270
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <262..>309
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61052.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       280..286
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..340
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>342
                     /gene="IGHG"
BASE COUNT           71 a           89 c          107 g           75 t
ORIGIN      
        1 acatgggtgg caaagccggg ggggtccctg agactctcct gcgcagcctc tggattcagt
       61 ttcagtcact acttcatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc
      121 tcagggatta acagtggtgg ggatactaca taccacgcag actccgtgaa gggcagattc
      181 accatgtcca gagagaacgc caggaacaca ctgtctcttc aaatggacgg cctgagagct
      241 gaggactcgg ctgtctatta ctgtgcgaga gatcgacgtg tacagtcgtt atcttggttc
      301 gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002571             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9085:7633
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002571
VERSION     KCXD01002571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9085:7633"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61053.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       424..433
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          141 c          127 g          101 t
ORIGIN      
        1 acatggggag caacacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaccacctt caccgaatta tccctgcact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aagttttaat cctatttatg gtgaaatttt
      301 acacacagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagaagcc tgatatctga ggacacggcc gtgtattact gtgcggcagc
      421 tgatagtggt tatccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01002572             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:10404:3208
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002572
VERSION     KCXD01002572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:10404:3208"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..446
     V_segment       74..370
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <362..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61054.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       379..387
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           90 a          125 c          128 g          105 t
ORIGIN      
        1 acatgggggc aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag
       61 atgggtcctg tcccaggtgc aactgcagga gtcgggccca ggactggtga agccttcaga
      121 gaccctgtcc ctcacctgcg ctgtctctgg aggctctctc agcggtggtt atgactggag
      181 ctggatccgc cagcccccag ggaaggggct ggagtggatt ggctatatct atggtgctag
      241 agggagcacc acctacaacc cgtccctcag gaatcgagtc accatttcaa aagacacgtc
      301 caagaaccag ttgtccctga agttgagttc tgtgaccgcc gcggacacgg ccgtatatta
      361 ttgtgcgaga cagtgctgtt attatgatga ctttttagac tactttgact tctggggcca
      421 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002573             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13856:7787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002573
VERSION     KCXD01002573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13856:7787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    149..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        149..512
     V_segment       149..440
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <434..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61055.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       450..467
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          104 a          157 c          133 g          120 t
ORIGIN      
        1 acatggggct ccctcaccac ccagctgggg atctcagtgc ttcattttct gtccttcatt
       61 tctcagtgct tgatttctgt cctccaccac gatggggtca actgccatcc tcgccctcct
      121 cctggctgtt ctccaaggag tctgtgccga ggtgcaactg gtgcagtctg gagcagaggt
      181 gaaaaggccc ggggaatctc tgaggatctc ctgtaagact tctggataca gcttcaccaa
      241 ttactggatc agttgggtgc gccagatgcc cgggaaaggc ctggagtgga tgggaatgat
      301 ctatcctagt gattctgatc ccagatacag cccgtccttc caaggccagg tcaccatctc
      361 agccgacaag tccatcagca ccgcctacct gcagtggagc agcctaaagg cctcggacac
      421 cgccacgtat tactgtgcga gagctggacg atacacctac agttacccct ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002574             357 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9082:14296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002574
VERSION     KCXD01002574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 357)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 357)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9082:14296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..355
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..355
     V_segment       7..279
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>324
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61056.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       280..288
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..355
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        356..>357
                     /gene="IGHG"
BASE COUNT           80 a           90 c          112 g           75 t
ORIGIN      
        1 acatgggggg ctgaagtgag gaagcctggg gtctcagtaa aggtctcctg caaggtttcc
       61 ggaaacacca tcaccgaatt atccgtgcac tgggtgcgac aggcccctgg aaaaggcctt
      121 gagtggatgg ggggtgttga tcccgtctat ggtgaaataa gacacgcaga gaacttccag
      181 ggcagagtca ccatgaccga ggacacgtcg acagacacag cctacatgga gctgagcagc
      241 ctgagatctg aggacacggc cgtctattac tgtgcgcgag gatattgtca tggtagttac
      301 tgttcctcgg gtcttgtctc ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002575             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16014:8442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002575
VERSION     KCXD01002575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16014:8442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61057.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          112 c          145 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cggtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcaacctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact ttggcataca
      241 ttgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt cgtctgatgg
      301 aagtaacaaa tactacgcta actctgtgaa gagccgattc accatctcca gagacaattc
      361 caagaacata ctatatcttc aaatgaacaa cttgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gatgatattg ggaccggttt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002576             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11503:19737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002576
VERSION     KCXD01002576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11503:19737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61058.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          114 c          148 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaaac tatggcctgc
      241 actgggtccg ccaggcccca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa attctacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccctgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002577             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:3769:7497
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002577
VERSION     KCXD01002577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:3769:7497"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61059.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       421..430
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          140 c          126 g          101 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatcc ctgcactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag ttttaatcct atttatggtg aaattttaca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agaagcctga tatctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttat ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01002578             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21803:15887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002578
VERSION     KCXD01002578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21803:15887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61060.1"
                     /translation="CARGIDNYHYTDTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          113 a          118 c          152 g          130 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatgttaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg actgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat gtccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatactg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002579             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:9055:19188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002579
VERSION     KCXD01002579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:9055:19188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61061.1"
                     /translation="CIRGPKFSWIRDAFDFW"
     D_segment       444..451
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..505
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          110 a          122 c          153 g          122 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ttacgacatg
      241 agctgggtcc gccaggctcc gggaaagggg ctggaatggg tctcatatat tagttacaat
      301 gatgaagtca aatactacgc tgactccgtg aagggccgtt tcaccatctc cagagacaac
      361 gccaagaact cgctgtctct gcagatgagc agcctgagag ccgaggacac ggccttgtat
      421 tattgtatta gaggcccaaa gtttagctgg atccgagatg cttttgattt ctggggccaa
      481 gggctcgggg tcaccgtctc ttcagcc
//
LOCUS       KCXD01002580             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:18860:19190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002580
VERSION     KCXD01002580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:18860:19190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61062.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          117 c          147 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga ttggctggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tttattactg tgcgagaggg gaatacagca actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002581             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6808:14685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002581
VERSION     KCXD01002581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6808:14685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61063.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          139 c          128 g           95 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagttg gtacagtctg gggttgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccagtct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatggtaaag tagactacac
      301 acagaagttc caagacagag tcaccatcac cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgacttct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01002582             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9631:23319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002582
VERSION     KCXD01002582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9631:23319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61064.1"
                     /translation="CARAGFSGSESFYGLDIW"
     D_segment       403..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           88 a          140 c          135 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc tcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt ctttggggac cctgtccctc acctgcgatg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccaggcc cccgggaagg gactggaatg
      241 gattggacgt ttctctggta gtggtggaaa caccgactac aacccctccc tcacctctcg
      301 agtcaccttt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga aatctgtgac
      361 cgccgcggac acggccgtct atttctgtgc gagagccgga tttagcggca gcgaaagttt
      421 ctacggtttg gatatttggg gccaaggggt cgccgtcacc gtctcctcag cc
//
LOCUS       KCXD01002583             356 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:4207:14507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002583
VERSION     KCXD01002583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 356)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 356)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:4207:14507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..354
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..354
     V_segment       8..289
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>323
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61065.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       295..300
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..354
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        355..>356
                     /gene="IGHG"
BASE COUNT           84 a           85 c          103 g           84 t
ORIGIN      
        1 acatgggggt ggagtctgga ggaggcttgg ttcagcctgg ggggtccctg agactctcct
       61 gtgcagcctc tggattcacc ttcagtaact atggcatgca ctgggtccgc caggctccag
      121 ggaagggcct ggagtgggtg gcagttatat cgtacgatga aaataagaaa tactacgcag
      181 actctctgaa ggaccgattc accatctcca gagacaattc caagaacatg ctttatcttc
      241 aaatgaacaa cctgaaattg gaggacacgg ccgtttatta ctgtgcgagg aggccctgga
      301 gtgcagatgc ttttgatttc tggggccaag gactcagggt caccgtctct tcagcc
//
LOCUS       KCXD01002584             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11254:7734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002584
VERSION     KCXD01002584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11254:7734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61066.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           95 a          139 c          129 g          107 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cggctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat caccagtagc tactggaact ggatccgcca gccccccggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagtactg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01002585             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7004:3450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002585
VERSION     KCXD01002585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7004:3450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61067.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       442..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          113 a          116 c          150 g          126 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtagttatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgca
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctctagaga
      361 caattccaag aatatgatat atctgctttt gaataccctg aaattggagg acacggccgt
      421 gtattactgt gtgagagtcc atgactacgc catgtactac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002586             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12455:7329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002586
VERSION     KCXD01002586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12455:7329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61068.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       442..447
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          112 c          154 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaagtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtggctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaatatt acgcagactc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aacatgctat attttcaaat gaacaacctg aaattggaag acacggccgt
      421 atattactgt gcgagagatg tctatggcag gggacttgac ttctggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002587             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12214:19272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002587
VERSION     KCXD01002587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12214:19272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..455
     V_segment       102..392
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61069.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       399..406
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          135 c          132 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc gagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtga
      181 ctctatcagc agttacttct ggaactggat ccgccaggcc ccagggaagg gactggaatg
      241 gattgggttt ctctatggta gtgatagtac ctccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtggaca cgtccaagaa ccaggtctcc ctgatactga gctctgtgac
      361 cgccgcggac acggccgtct attactgtgc gaccgggaag cggcagttgg atcttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002588             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4862:16323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002588
VERSION     KCXD01002588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4862:16323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61070.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       412..416
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           92 a          138 c          132 g          102 t
ORIGIN      
        1 acatggggaa aggttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggcgccat cagcagtggt ttctactgga cctggatccg ccaaccccca gggaaggggc
      241 tggagtggat tgggtgtatc ggtggtaata gtgggaccac ctactacaac ccctccctca
      301 agagtcgagc cgccatttca aaagacacgt ccaacaatca attctccctg aggttgagtt
      361 ctctgaccgc cgcggacacg gccgtgtatt actgtgcgag agatgaagac ccctccattt
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002589             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18981:5225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002589
VERSION     KCXD01002589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18981:5225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..325
     V_segment       7..255
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <247..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61071.1"
                     /translation="CAKSRSSSLHWDFDFW"
     D_segment       263..269
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..325
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           73 a           94 c           88 g           72 t
ORIGIN      
        1 acatgggggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
       61 gctatgcact gggtccgcca ggctccaggt aaggggctgg agtgggtctc agctatgagt
      121 gttgctggaa gcacatacta cgcaggctcc gtgaagggcc gattcaccgt ctccagagac
      181 aactcaaaga acatgttctc cctgcaaatg gacaacctga cacctgagga cacggccgtg
      241 tattactgtg cgaaaagtcg gagtagtagc cttcactggg acttcgattt ctggggccct
      301 ggcaccccaa tcacaatctc ctcagcc
//
LOCUS       KCXD01002590             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18613:17668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002590
VERSION     KCXD01002590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18613:17668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61072.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       440..445
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          114 c          157 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggt ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt atctctggca
      241 tgcactgggt ccgccaggct ccagggcagg ggctggattg ggtggcagtt gaatcgtttg
      301 atggaggtaa gaaatactac gctgactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga gcaacctgaa attggaggac acggccgtgt
      421 attactgtgt gagagatgcc tacgggggcg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002591             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22150:7187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002591
VERSION     KCXD01002591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22150:7187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61073.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       417..423
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          139 c          142 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctccaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatact gtatctgatg gagtgatata
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagta cacggccgtt tattactgtg cgagaggtgt
      421 gacagcagac gtcttcggtt tcctcgggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002592             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14738:5926
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002592
VERSION     KCXD01002592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14738:5926"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..482
     V_segment       122..415
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61074.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       425..434
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           98 a          148 c          130 g          108 t
ORIGIN      
        1 acatgggggt ctccctcacc gcacatctgg gatctcagtg cttccttttc tgtcctccac
       61 cacgatgggg tcaactgcca tcctcaccct cctactggct gttctccaag gagtctgtgc
      121 cgaggtgcaa ctggtacagt ctggaccaga ggtgaaaagg cccggggagt ctctgaagat
      181 ctcctgtaag acttctggat accgctttac cagctactgg atcacctggg tgcgccagat
      241 gcccgggaaa ggcctggagt ggatgggggc gattgatccc ggtgattctg ctaccaaata
      301 cagcccgtcc ttccaaggcc aggtcaccat ttcagccgac aagtccatca ccaccgccta
      361 cctggagtgg agcagcctga aggcctcgga caccgccacg tattactgtg cgaaaggtcc
      421 cggagtgatt attaactact ttgactactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01002593             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18380:20595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002593
VERSION     KCXD01002593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18380:20595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61075.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       406..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          137 c          129 g          107 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagttcct actggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tatatctatg gtagtactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtcaaa gaaccagttc tccctgaagc tgagttctgt
      361 gaccgccgcg gacaccgccg tctattactg tgcgagatat ggagatgata gtgttcatta
      421 caactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002594             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9125:15464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002594
VERSION     KCXD01002594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9125:15464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61076.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       418..431
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          116 a          138 c          141 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacgga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggcggca gcaactacag gcgcccactc
      121 tgaagtccac ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcattggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gcatctggtg aaatcatata
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgcctacag acacagccta
      361 catggagttg agcagcctga gatctgagga cacggccgtg tattactgtg cgagaggata
      421 ttgtagtggt agtcactgct cctccggatt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctct gcc
//
LOCUS       KCXD01002595             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17964:10830
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002595
VERSION     KCXD01002595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17964:10830"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61077.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          144 c          148 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg gctggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggagca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgacttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga gttgttgatc ctgtaaatgg tgaaatgata
      301 cacgcagaga tgttccaggc cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcgtctg gtccagcctc ttcaacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002596             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23398:12092
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002596
VERSION     KCXD01002596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23398:12092"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61078.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          150 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagttatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 ctgatgaaag taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002597             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8239:8216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002597
VERSION     KCXD01002597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8239:8216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61079.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          112 c          154 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatgcta tattttcaaa tgaacaacct gaaattggaa gacacggccg
      421 tgtattactg tgcgagagat gtctatggca ggggacttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002598             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20221:11471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002598
VERSION     KCXD01002598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20221:11471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61080.1"
                     /translation="CVSGFSVWLFNDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          123 c          150 g          106 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cggcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgtgagtggg
      421 tttagtgtct ggttatttaa cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002599             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:19775:18680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002599
VERSION     KCXD01002599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:19775:18680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    80..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        80..437
     V_segment       80..373
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <365..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61081.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       380..386
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT           99 a           98 c          129 g          113 t
ORIGIN      
        1 acatgggcac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
       61 tttaagaggt gcccagtgtg aggtacaatt ggtggagtct ggaggaggtt tgggtcagcc
      121 tggggggtcc ctgagactct cctgtgaaac ttctggattc accttcagta attatggcat
      181 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tttcgtatga
      241 tgtaagtaag acatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      301 ttctaagaac atgctatatc ttcaaatgag caacctgaaa ttggaggaca cggccgtgta
      361 tttctgtgcg agacgccctt ggaacgctga ctactttgac tactggggcc agggagtcct
      421 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002600             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17011:6075
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002600
VERSION     KCXD01002600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17011:6075"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61082.1"
                     /translation="CTRIGVGSLATAGAYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          110 a          132 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgagaca ggagcctcag ccctggattc caagaacttc cagtttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcaact ggtgcagtct gggggaggct tggtccagcc
      181 tggggggtca ctgagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttcgtaacac
      301 tggtaaaacc atatactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tccctgtctc tacaaatgaa cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaattggcg tcggatctct agcaacggct ggtgcctact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002601             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12437:5901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002601
VERSION     KCXD01002601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12437:5901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..271
     V_segment       8..193
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61083.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       202..212
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       222..271
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           61 a           78 c           79 g           55 t
ORIGIN      
        1 acatggggga tccgccagtc cccagggaag ggactggagt ggattggacg tatctctggt
       61 agtggtggga acaccgtcta caacccctcc ctcaagagtc gagtcaccat ttcaacagac
      121 acgtccaaga accagatctc cctgaaagtg acctctgtga ccgccgcgga cacggccgtg
      181 tattattgtg cgacagccgg atatagcagc agggaaagct tctacggttt ggattcctgg
      241 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002602             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14421:10504
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002602
VERSION     KCXD01002602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14421:10504"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61084.1"
                     /translation="CARDESALSYPFEYW"
     D_segment       413..417
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           88 a          145 c          133 g           99 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gcccccatca gcagtaacta ctggacctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggac gcatctatgg tgttcgtggg actaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaaggt gacctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgcgagacg agagcgcctt gtcttacccc
      421 tttgagtact ggggccaggg agtctcggtc accgtctcct cagcc
//
LOCUS       KCXD01002603             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20083:9302
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002603
VERSION     KCXD01002603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20083:9302"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    52..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        52..430
     V_segment       52..344
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <337..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61085.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       365..376
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..430
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT           90 a          112 c          137 g           93 t
ORIGIN      
        1 acatggggga ggctcctctt tgtggtggca gcagctacag gtgcccagtc ccaggtccaa
       61 ctggtggagt ccggggctga ggtgaagaag cctggggcct cagcgaagct ctcctgcaag
      121 gccgctggat acattttcag tacctctgcc atcagttggc tgcgacaggc ccctggacaa
      181 gggcttgagt ggatgggggg gatcatgcct cttgttggta gaacaaacta cgcacagagg
      241 ttccagggca gagtcacgat taccgcggac acgtccacaa ggacagccaa catggagctg
      301 agcagcctga catctgagga cacggccgtg tattactgtg cgagcggtgg tttccaggat
      361 gagaacggtt actattttcc agactatttt gacttttggg gccagggagt cctggtcacc
      421 gtctcctcag cc
//
LOCUS       KCXD01002604             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:16966:10639
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002604
VERSION     KCXD01002604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:16966:10639"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61086.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          148 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcttcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtcagttatt tcgaatgatg
      301 aaaataacaa atactacgca gactctgtga aggaccgatt caccatttct agagacaatt
      361 ccatgaacat gctttttctt caaatgaaca acctgaactt ggacgacacg gccgtctatt
      421 actgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002605             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:28020:8242
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002605
VERSION     KCXD01002605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:28020:8242"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61087.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           99 a          139 c          135 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccctcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atcagtgcta gtagtggaaa caccgactac aaccccgccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgcccaagaa ccagttctcc ctgatgctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002606             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10138:7776
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002606
VERSION     KCXD01002606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10138:7776"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61088.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          142 c          150 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgaaatg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gtgaaataat
      301 acacgcagag aacttccagg gcagagtcac catggccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgagatctga cgacacggcc gtatattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccagcct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002607             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16346:14320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002607
VERSION     KCXD01002607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16346:14320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..519
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61089.1"
                     /translation="CARTSYGGSYYFFYFDYW"
     D_segment       456..470
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..519
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>523
                     /gene="IGHG"
BASE COUNT          119 a          126 c          146 g          132 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagcact gaacacaaga gactcaccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gctactggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgacta
      241 tgccatgagc tgggtccgcc agacttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaaatct aataattacg cgacagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaaga acacgctata tctacaaatg accagcctga aaaccgagga
      421 cacggccgtg tattactgtg ctagaacttc ctatggtggt agttattact tcttctactt
      481 tgactactgg ggccagggag tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01002608             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12433:16147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002608
VERSION     KCXD01002608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12433:16147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61090.1"
                     /translation="CARWGTPFDYW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           87 a          134 c          133 g          102 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcttgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcgc tgtctctggt
      181 agctccatca acagtggtta tgcctggggc tggatccgcc agcccccagg gaaggggctg
      241 gagtgggttg gtcataccta tgatagtagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttctaa agacacgtcc aagaaccagt tctccctgag gctgaattct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagat gggggacccc ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002609             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8382:5122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002609
VERSION     KCXD01002609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8382:5122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61091.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          115 c          154 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccactgtgaa gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagtct ctgggttcac cttcagtggc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcggttata tcgaatgatg
      301 gaactaacaa atactacgca gactctctga aggaccgatt tagtatctcc agagagaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaact ggaggacacg gccgtctatt
      421 actgcgcgac agatgcgttt ggtagcggga ttgactactg gggccgggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002610             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20371:9348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002610
VERSION     KCXD01002610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20371:9348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..358
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..358
     V_segment       8..287
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61092.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       299..308
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       313..358
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        359..>362
                     /gene="IGHG"
BASE COUNT           72 a          109 c          101 g           80 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcacctgcg
       61 ctgtctctgg tgactccatc accagtacct actggaactg gatccgccag cccccaggga
      121 aggggctgga gtggattgga tttatctatg gtgctactgg gagcaccggc tacaacccct
      181 ccctcaagag tcgagtcacc atctcaacag acacgtccaa gaaccagttt tccctgaagc
      241 tgagctctgt gaccgccgcg gacaccgccg tgtattactg tgcgagatat gatcagtggg
      301 atgattacct gtactacttt gactactggg gccagggagt cctggtcacc gtctcctcgt
      361 cc
//
LOCUS       KCXD01002611             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16685:14704
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002611
VERSION     KCXD01002611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16685:14704"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61093.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          121 c          146 g          126 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgcgaag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca gatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002612             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13968:13001
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002612
VERSION     KCXD01002612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13968:13001"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61094.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          112 a          122 c          154 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcaa ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcaag tattaatagt
      301 ggtggggaaa gcacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactata tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002613             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13994:21865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002613
VERSION     KCXD01002613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13994:21865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61095.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          111 c          158 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtatctttgg
      241 catgcattgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaagt aagaaatact acacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aaaatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgc gcgagagacg attttggcag cggcttaggg tactggggcc agggagccct
      481 ggtgaccgtc tcctcagcc
//
LOCUS       KCXD01002614             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19554:8628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002614
VERSION     KCXD01002614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19554:8628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61096.1"
                     /translation="CAGGAYANLDYW"
     D_segment       443..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          125 c          154 g          110 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca aatggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagatactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctcttaatta
      301 tgatggggat agtacatact acgcagactc cgtgaagggt cgattcacca tctccagaga
      361 caactcaaag aacacgctct ccctgcaaat gcacagcctg agagaggatg acacggccgt
      421 atatttctgt gcgggcgggg cgtacgctaa cctcgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002615             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20405:9806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002615
VERSION     KCXD01002615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20405:9806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..499
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61097.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       439..446
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>505
                     /gene="IGHG"
BASE COUNT          121 a          142 c          143 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttcgtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgt aaagtttccg gatacacggt catcgattta tccattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgaacatg gtgaagtaat
      301 atacgcagac aacttccagg gcagagtcgc catgagcgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgacatctga ggacacggcc gtgtattact gtgcgaccca
      421 cggaggatat agaggcatct ggaactccct atactacggt ttcgattcct ggggccaagg
      481 ggtcgtcgtc accgtctccc cagcc
//
LOCUS       KCXD01002616             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10477:8421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002616
VERSION     KCXD01002616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10477:8421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61098.1"
                     /translation="CATGRFGSSVWSTLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          112 a          143 c          150 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgagatgtc catgcactgg gtgcgacagg
      241 cccctggaaa ggggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg acatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccaccctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002617             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:19486:13768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002617
VERSION     KCXD01002617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:19486:13768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..508
     V_segment       138..431
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61099.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       454..461
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>512
                     /gene="IGHG"
BASE COUNT          104 a          130 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc tttgctattt
      121 taaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gtccagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac ctttggtgat tatggcatgc
      241 actgggtccg ccaggctccg ggaaagggac tggagtgggt ctcatccatt aggaacactg
      301 gtaaaatcgt atactacgct gactccgtga agggccgatt caccatttcc agagacaacg
      361 ccaagaactc gctgtctctg cgaatgagca gcctgagagc cgaggacacg gccgtgtact
      421 actgtactag aattggcgtc ggatctctgg caacggctgg tgactacttt gaccactggg
      481 gccagggagt cctggtcacc gtctcctccg cc
//
LOCUS       KCXD01002618             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15530:12675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002618
VERSION     KCXD01002618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15530:12675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61100.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          113 c          150 g          121 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggagggg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcatc
      301 tgatggaagt aagaaatact acgcaaactc tgtgaaggac cgattcatca tctccagaga
      361 caattccaag aacatagtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002619             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4387:19019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002619
VERSION     KCXD01002619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4387:19019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..498
     V_segment       123..412
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61101.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       450..456
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          119 c          154 g          120 t
ORIGIN      
        1 acatgggggc cccagaattc ccaggtattt ctgttcggcg atcagcacta aacacagaac
       61 ataccatgga gtttgtgctg agctgggttt tccttgttgc tcttttgaaa ggtgtccagt
      121 gtgaggtgca cctggtgcag tctgggggcg gcttgacaaa gccggggggg tccctgagac
      181 tctcctgtgc agcctccgga ttcaccttca gtgactacta tatggactgg gtccgccagg
      241 ctccagggaa ggggctggag tgggtctcac gaatcggtca tgatggtggt agcacatggt
      301 acgcagactc cgtgaagggc agatttacca tttccagaga gaatgccaag aacacactgt
      361 ttcttcaaat ggacagcctg agaagtgagg acacagccgt atattactgt gccagagagc
      421 ggtttggggg aattggggta attatcttca actggatcga tgtctggggc ccgggagtcc
      481 tggtcaccgt cccctcagcc
//
LOCUS       KCXD01002620             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10212:12947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002620
VERSION     KCXD01002620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10212:12947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..462
     V_segment       107..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61102.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>468
                     /gene="IGHG"
BASE COUNT           94 a          132 c          130 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccgggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcgt tgtctctggt
      181 gactccatca gcaatagcta ttggaactgg atccgccagc cccctgggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct ccgcagcc
//
LOCUS       KCXD01002621             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12348:16246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002621
VERSION     KCXD01002621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12348:16246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61103.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..412
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           85 a          140 c          136 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcgggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacct ctggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ttgtcagtgg tagtggtggg agcaccgact acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaatct gatttctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgcgagtcc ggggcgtaac tatacactac
      421 tttgactact ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01002622             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22080:13240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002622
VERSION     KCXD01002622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22080:13240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61104.1"
                     /translation="CAATGEPLEYFDFW"
     D_segment       403..407
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..461
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           90 a          133 c          138 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga gtggtgaggc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 atctatcagc agtggttatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatatctatg gtactagtgg gagcaccaac tacaatgcgt ccctcaagaa
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccagttc tccctgcagt tgaggtctgt
      361 gaccgccgcg gacacggccg tttattactg tgcggcgaca ggggaacccc ttgaatactt
      421 cgacttctgg ggccagggcg ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002623             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14454:14358
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002623
VERSION     KCXD01002623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14454:14358"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61105.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       404..414
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          138 c          138 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctttgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tggctccatc agcagtaact actggagctg gatccgccag tccccaggga agggactgga
      241 gtggattgga cgtatctctg gtagtggtgg gagcaccgtc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagatc tccctgaaag tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgacagcc ggatatagca gcagtgaaag
      421 cttctacggt ttggattcgt ggggccaagg ggtcgtcgtc tccgtctcct cagcc
//
LOCUS       KCXD01002624             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20852:6537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002624
VERSION     KCXD01002624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20852:6537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61106.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggac tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaagtc tgtgaaggac cgattcacca tattaagaga
      361 caattccaac agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002625             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4799:10363
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002625
VERSION     KCXD01002625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4799:10363"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61107.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       423..429
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          137 c          151 g           99 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgca agtgatgaag taatacacgc
      301 agatggtttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gagggaggtt
      421 cggtagtagc gtctggtcca atctcgtcta tggtttcgat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002626             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16489:19531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002626
VERSION     KCXD01002626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16489:19531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61108.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          156 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg cggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc tatggcatgc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt gacggttata tcgaatgatg
      301 gaagtaagaa atactacgcg gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acgtgaaatt ggaggacacg gccgtctatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002627             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17993:17215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002627
VERSION     KCXD01002627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17993:17215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61109.1"
                     /translation="CGRDDSGVLIDYW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          118 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgac
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgg
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catgcactgg gtccgcctgg ctccagggca ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acgcagactc tgcgaaggac cgattcacca tctccagaga
      361 caattccaag aacctggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg attctggggt ccttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002628             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8111:14925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002628
VERSION     KCXD01002628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8111:14925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61110.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          113 c          154 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggca ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002629             272 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15879:14791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002629
VERSION     KCXD01002629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 272)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 272)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15879:14791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..268
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..268
     V_segment       7..209
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <201..>239
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61111.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       212..220
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       231..268
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        269..>272
                     /gene="IGHG"
BASE COUNT           72 a           60 c           83 g           57 t
ORIGIN      
        1 acatgggcta tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
       61 cagttatgtc gaatgatgga agtaagaaat actacggaga ctctgtgaag gaccgattca
      121 ccatctccag agacaattcc aagaacaggc tatatcttca aatgaacaac ctgaaattgg
      181 aggacacggc agtgtattac tgtgcgagag atgatagtgg ggtgatcatc gactactggg
      241 gccagggagt cctggtcacc gtctcctccg cc
//
LOCUS       KCXD01002630             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21387:16377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002630
VERSION     KCXD01002630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21387:16377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61112.1"
                     /translation="CARYQVEFLDYLNEAFDLW"
     D_segment       411..416
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           93 a          129 c          136 g          119 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgag gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgct gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctgat
      181 ggctccatca ccagtagtta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ttttctatgg tggtagtggg agcaccatct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga gacgtccaag aaccagtttt ccctgaagtt gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatc aggttgaatt cctggactat
      421 ttaaatgaag cttttgattt atggggccaa gggctcaggg tcaccgtctc ttcagcc
//
LOCUS       KCXD01002631             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12651:11289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002631
VERSION     KCXD01002631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12651:11289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..329
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61113.1"
                     /translation="CARVGENTGGAEDFDFW"
     D_segment       264..272
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       285..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           77 a           78 c           95 g           81 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtga agtctctgga ttcaccttca gtacctttgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcac ttatatcgta
      121 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      181 caattccgag aacatgctat ttcttcaaat gaacaacctg aaattggacg acacggccgt
      241 gtatttctgt gcgagagttg gagagaatac tggtggtgcg gaggactttg acttctgggg
      301 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002632             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12553:20653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002632
VERSION     KCXD01002632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12553:20653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..493
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61114.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       445..453
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          112 a          114 c          151 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcatctgg aggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtaacct ctggattcac cttcagtagc tatggcatgc
      241 actgggcccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagat ttactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctctatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agaggagaaa tttggctaca gttttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcggcc
//
LOCUS       KCXD01002633             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16757:10919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002633
VERSION     KCXD01002633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16757:10919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61115.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       449..463
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          104 a          121 c          160 g          128 t
ORIGIN      
        1 acatggggga gctctaggag aggagcccag ccctgggatt cccaggtgtt ttcatttgtg
       61 atcagcactg aacgcagaag actcatcatg gagtttggcc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gggtgaggtg cagctggtgg agtccggggg cggcttggca
      181 gagcctgggg ggtccctgag actctcctgt gcagcctctg gattcatctt cagtaactac
      241 tggatgtact gggttcgcca ggcaccaggg aaggggctgg agtggatctc agctattaat
      301 agcgctgata gtggcacata ctatgcagac tccgtgaagg gcagattcac catttccagg
      361 gacaacgcca ggaacacact gtttcttcaa atggacagcc tgagagttga ggacacggct
      421 gtctattact gtgcgagagt accgggccta gtggttttta ctggttccct tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002634             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6934:15182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002634
VERSION     KCXD01002634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6934:15182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..428
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61116.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       439..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          125 c          154 g          113 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccattgtg aggtgcagct ggtggagtcg gggggcggct tggcaaagcc
      181 tggggggtcc ctaagactct cctgtgcagc ctccggattc accttcagtg accactgcat
      241 gcactgggtc cgccaggctt cagggaaggg gctggaatgg gtctcaggta ttacttatac
      301 tggtgttacc acatggtacg cagactccgt gaggggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactatatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgtg gcaggaaggc ggcacgtgga ccttgactac tggggccagg gagtcgtggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002635             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21596:10684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002635
VERSION     KCXD01002635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21596:10684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61117.1"
                     /translation="CATGRIGTSGWSNLFNGLDSC"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          119 a          148 c          142 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgag caagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caagttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgacatctg aggacacggc catctactac tgtgcgacag
      421 ggaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tgcggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01002636             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11541:13027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002636
VERSION     KCXD01002636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11541:13027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..508
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61118.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       435..441
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          114 a          112 c          160 g          124 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgctgctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gcttcagtgg ctttggcata
      241 cactgggtcc gccaggctcc tgggaagggg ctggagtggg tgtcacttat atcgtatgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccttgtc cagagacaat
      361 tccaagaaca tggtatatct tcacatgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttctgtgcga gagttagtgg gcatacagag gggacagttg aaaactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002637             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12116:19169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002637
VERSION     KCXD01002637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12116:19169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..489
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61119.1"
                     /translation="CANGMSGLDYW"
     D_segment       434..438
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          105 a          121 c          154 g          111 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccttgaga ctctcctgtg cagcctctgg attcaccttc agtcgctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattagta
      301 gtggtggtaa cacatacctc gcagactccg tgaagggccg attcaccatc tccagagacg
      361 actcaaagaa cacagtctcc ttgaaaatga acagtctgag acctgaagac acggccgcgt
      421 attactgtgc gaatgggatg tcagggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01002638             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11329:4382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002638
VERSION     KCXD01002638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11329:4382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61120.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           94 a          138 c          130 g          101 t
ORIGIN      
        1 acatggggga ggttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggcgccatc agcagtggtt tctactggac ctggatccgc caacccccag gaaaggggct
      241 ggagtggatt gggtgtatcg gaggtaatag tggtaccacc tactacaacc cctccctcaa
      301 gagtcgagcc accatttcaa aagacacgtc caacaatcaa ctctccctga agctgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002639             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:23203:10154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002639
VERSION     KCXD01002639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:23203:10154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61121.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       413..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          106 a          145 c          135 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcccggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgtatat ggtgaaatga
      301 tgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggagc
      361 tgagcagcct gacatctgac gacacggccg tctattactg tgcgattggc cctagcggca
      421 gttggaacca ctggtccttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01002640             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:25094:7751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002640
VERSION     KCXD01002640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:25094:7751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..503
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61122.1"
                     /translation="CARVGENTGGAEDFDFW"
     D_segment       438..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          112 c          155 g          124 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttggtatttt
      121 aagaggtgtc cagtgtgagg tacaactggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgaagtctc tggattcacc ttcagtacct ttggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg tcacttatat cgtatgatgg
      301 aagtaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 cgagaacatg ctatttcttc aaatgaacaa cctgaaattg gacgacacgg ccgtgtattt
      421 ctgtgcgaga gttggagaga atactggtgg tgcggaggac tttgacttct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002641             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15019:13718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002641
VERSION     KCXD01002641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15019:13718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61123.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       430..436
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          139 c          152 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacacct acaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgcaaat ggtgaaataa
      301 tacacgcaga tggtttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcggc ctgagatctg aggacacggc cgtgtattac tgtgcgagag
      421 ggaggttcgg tagtagcgtc tggtccaatc tcgtctatgg tttcgattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002642             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12501:21745
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002642
VERSION     KCXD01002642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12501:21745"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61124.1"
                     /translation="CARDRFMGIGALGYW"
     D_segment       402..406
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           91 a          132 c          144 g          103 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg taagagcatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc agcagtggtg aagccttcgg agaccctgtc cctcacctgc gaagtctctg
      181 gtggctccat cagcggtggt tatggctgga cctggatccg ccaggcccca gggaagggac
      241 tggagtgggt tgggagaatg tatggtagca gtggtagcac ctactacaac ccctccctca
      301 agggtcgagt caccatttca aaagacacgt ccaagatcca gttctccctg aagctgacct
      361 ctgtgaccgc cgcggacacg gccgtttatt attgtgcgag agataggttc atgggcatag
      421 gggctctcgg ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002643             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16389:4118
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002643
VERSION     KCXD01002643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16389:4118"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61125.1"
                     /translation="CARGGNFWSGYSAGALDVW"
     D_segment       428..437
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          131 c          154 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccattc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattctcc atccactggg tacgacaggc
      241 ccctggaaag gggcttgagt ggatgggagg tgttgatcct atgaatggtg aagcagttgc
      301 agacaagttc cagggcagag tcaccatgac cgaggacacg tctgcagaca cagcctacat
      361 ggaactgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcga gaggggggaa
      421 tttttggagt ggttattccg ccggggcatt ggatgtctgg ggccggggag ttctggtcac
      481 cgtctcgtca gcc
//
LOCUS       KCXD01002644             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15487:15969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002644
VERSION     KCXD01002644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15487:15969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61126.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          116 a          143 c          130 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg gaaagtagac
      301 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggagc tgagcagcct gagatctgag gacacggcca cttattactg tgtgacagtg
      421 ggtccctacc attactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002645             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20740:14323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002645
VERSION     KCXD01002645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20740:14323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61127.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       423..431
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          113 a          143 c          134 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaact acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaaatgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagcagcct gacatctgag gacacggccg tgtattactg cgcgattggc cctagtggca
      421 gatggaacga ctggtccttc gacatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01002646             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20253:16664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002646
VERSION     KCXD01002646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20253:16664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61128.1"
                     /translation="CARAGFSGSESFYGLDIW"
     D_segment       405..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           90 a          139 c          135 g          110 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gctcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gtctttgggg accctgtccc tcacctgcga tgtctctggt
      181 ggctccatca gcagtaacta ctggagctgg atccgccagg cccccgggaa gggactggaa
      241 tggattggac gtttctctgg tagtggtgga aacaccgact acaacccctc cctcacctct
      301 cgagtcacct tttcaacaga cacgtccaag aaccagtttt ccctgaggct gaaatctgtg
      361 accgccgcgg acacggccgt ctatttctgt gcgagagccg gatttagcgg cagcgaaagt
      421 ttctacggtt tggatatttg gggccaaggg gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01002647             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8239:7472
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002647
VERSION     KCXD01002647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8239:7472"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61129.1"
                     /translation="CARYDADDYGYYFLDYW"
     D_segment       405..414
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           89 a          140 c          130 g          109 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca tttgcgctgt ctctgggggc
      181 tccatcacca gtagcttctg gaactggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggtata tctctggtgc tactgggagt accagctaca atccctccct caagagtcga
      301 gtcaccatct caacagacac gtccaacaac cacttttccc tgaggctgaa ctctgtgacc
      361 gccgcggaca ccgccgtgta ttactgtgcg agatatgacg cggatgacta cggttattat
      421 ttccttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002648             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8901:14890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002648
VERSION     KCXD01002648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8901:14890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..500
     V_segment       131..422
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <416..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61130.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       427..441
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT           93 a          150 c          139 g          120 t
ORIGIN      
        1 acatgggggg ggatctcagt gcttcatttt ctgtccttca tttctcagtg cttcatttct
       61 gtcctccacc acgatggggt caactgccat cctcgccctc ctcctggctg ttctccaagg
      121 agtctgtgcc gaggtgcagc tggtgcagtc tgtagcagag gtgaagaggc ccggggaatc
      181 tctgaggatc tcctgtcaga cttctggata cagttttgcc aactactgga tcgcctgggt
      241 gcgccagatg cccgggaaag gcctggagtg gatggggatc atctatcctg gtgattctga
      301 caccaagtac ggcccgtcct tcgaaggcca ggtcaccatc tcagccgaca agtccaccag
      361 caccgcctac ctgcagtgga gcagcctgaa ggcctcggac accgccacgt attactgtgc
      421 gagactctgg ggtgattatt acgcactcca gtactacttc gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002649             287 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:27977:14040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002649
VERSION     KCXD01002649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:27977:14040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..285
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..285
     V_segment       6..224
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <216..>254
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61131.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       226..230
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       239..285
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        286..>287
                     /gene="IGHG"
BASE COUNT           68 a           70 c           81 g           68 t
ORIGIN      
        1 acatgggatt caccttcagt acctctggca tgcactgggt ccgccaggct ccagggaagg
       61 ggctggagtg ggtgtctgta atttcgtctg atggaagtaa gaaatactac gcagactctg
      121 tgaaggaccg attcaccatc tccagagaca actccaagaa catactatat cttcaaatga
      181 acaacctgaa attggaggac acggccgtgt atttctgtgt gagagatgcc ttcgggggcg
      241 gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002650             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16555:4233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002650
VERSION     KCXD01002650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16555:4233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61132.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       444..451
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          118 c          149 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaaga ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtc caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagcaactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tacgatgaaa gtaagaaata ctacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct ttatcttcaa atgaacaacc tgaaaatgga ggacacggcc
      421 gtttattact gtgcgaggag gccctggaat gcagatgctt ttgatttctg gggccaagga
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01002651             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4161:11239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002651
VERSION     KCXD01002651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4161:11239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..473
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61133.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>478
                     /gene="IGHG"
BASE COUNT          108 a          145 c          134 g           91 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcag gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctgtatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac ttggaactga
      361 gcggcctgac ttctgaggac acggccgtgt attactgtgc gactggccct accggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcccagcc
//
LOCUS       KCXD01002652             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:11687:4067
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002652
VERSION     KCXD01002652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:11687:4067"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61134.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          118 c          150 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcggc
      181 ctggggggtc cctgagactc tcctgttcag cctctggatt caccttcagt agttttggca
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa gttggaggac acggccgtct
      421 attattgtgc gagagacgca tttggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002653             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18930:5275
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002653
VERSION     KCXD01002653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18930:5275"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    151..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        151..514
     V_segment       151..442
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61135.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       452..469
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          102 a          157 c          135 g          122 t
ORIGIN      
        1 acatgggggt ctccctcacc acccagctgg ggatctcagt gcttcatttt ctgtccttca
       61 tttctcagtg cttcatttct gtcctccacc acgatggggt caactgccat cctcgccctc
      121 ctcctggctg ttctccaagg agtctgtggc gaggtgcagc tggtgcagtc tggagcagag
      181 gtgaaaaggc ccggggaatc tctgaggatc tcctgtaaga cttctggata cagctttacc
      241 acttactgga tcaattgggt gcgccagatg cccgggaaag gcctggagtg gatgggaatg
      301 atctatccta gtgattctga tcccagatac agcccgtcct tccaaggcca ggtcaccatc
      361 tcagccgaca agtccatcag caccgcctac ctgcagtgga gcagcctgaa ggcctcggac
      421 accgccacgt attactgtgc gagagctgga cgatacacct acagttaccc ctttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002654             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23873:10126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002654
VERSION     KCXD01002654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23873:10126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..459
     V_segment       84..383
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61136.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       388..404
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..459
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           99 a          140 c          117 g          105 t
ORIGIN      
        1 acatgggggg actcctgtgc cccaccatgg acacgctttg ctacacactc ctgctactga
       61 ccgtcccgtc ctgggtcttg tcccaggtga ccttgaagga gtctggtcct gcgcttgtga
      121 aacccacaca gaccctcacg ctgacctgca ccttctctgg gttctcaatc agtacttctg
      181 caacaggtgt gggctggatc cgtcagcccc cagggaaggc cctggaatgg cttgcaagca
      241 tttattggaa tgatactaaa ttcttcagca cttcgctgaa gagcagactc accgtctcca
      301 aggacacctc caaaacccag gtggttctaa caatagccaa catggaccct gtggacacag
      361 ccacatatta ctgtgcacgg atacagggtg gtagttacta ctacggtggg ggatacttcg
      421 agttctgggg ccagggcgcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002655             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13093:15712
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002655
VERSION     KCXD01002655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13093:15712"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..498
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61137.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       425..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..498
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          149 c          138 g          103 t
ORIGIN      
        1 acatggggac acatagcaac catgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtacag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacaccttca acatctatgc catcaattgg gtgcgacagg
      241 cccctggaca ggggcttgag tggatgggag ggatcatccc tcttgttgat atgacaaact
      301 acgcacagag gttccagggc agagtcacga ttaccgcgga cacgtccaca gccacagcct
      361 tcttggaact gagcagcctg agatctgacg acacggccat ttattactgt gcgagagccc
      421 gggcctacgg tagcggctac cgctcagact ggttcttcga tgtctggggc cctggcaccc
      481 caatcaccat ctcctcagcc
//
LOCUS       KCXD01002656             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:8725:8290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002656
VERSION     KCXD01002656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:8725:8290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61138.1"
                     /translation="CANALTGGLDYW"
     D_segment       441..449
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          124 c          157 g          108 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 caccactgaa cacagaggac gcaccatgga gtctgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagatattg
      241 gatgaactgg gtccgccagg ctccagagaa ggggctggag tgggtctcag ctattactag
      301 tggtggggaa agtacacatt acgcagactc cgtgaagggt cgattcacca tctccagaga
      361 caactcaaag aacacgctct ccctgcaaat ggacagcctt agagcggagg acacggccat
      421 atattactgt gcgaacgcgt taactggggg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002657             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9254:7472
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002657
VERSION     KCXD01002657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9254:7472"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61139.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       439..445
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          102 a          125 c          154 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcagct tcagttacta cttcatgagt
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattac cagtggtggg
      301 gctaacacat actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaccacac tgtatcttca catggacagc ctgagagctg aggacacggc tgtctattac
      421 tgtgtaagag atcgacgtgt acagtcgtta tcctggttcg atgtctgggg cccgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002658             401 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4552:10996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002658
VERSION     KCXD01002658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 401)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 401)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4552:10996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..399
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..399
     V_segment       24..313
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>368
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61140.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       351..357
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       358..399
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        400..>401
                     /gene="IGHG"
BASE COUNT           87 a           95 c          131 g           88 t
ORIGIN      
        1 acatggggaa aggtgtccag tgtgaggtgc acctggtgca gtctgggggc ggcttgacaa
       61 agccgggggg gtccctgaga ctctcctgtg cagcctccgg attcaccttc agtgactact
      121 atatggactg ggtccgccag gctccaggga aggggctgga gtgggtctca cgaatcggtc
      181 atgatggtgg tagcacatgg tacgcagact ccgtgaaggg cagatttacc atttccagag
      241 agaatgccaa gaacacactg tttcttcaaa tggacagcct gagaagtgag gacacagccg
      301 tatattactg tgccagagag cggtttgggg gaattggggt aattatcttc aactggatcg
      361 atgtctgggg cccgggagtc ctggtcaccg tcccctcagc c
//
LOCUS       KCXD01002659             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15541:13850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002659
VERSION     KCXD01002659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15541:13850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61141.1"
                     /translation="CARYEGAAAGTWFFDYW"
     D_segment       406..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          142 c          131 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccaatcatta ctggaactgg atccgccagc cccccgggaa gggactggag
      241 tgggttgggt ctctctatgg tgctactggg agcaccaact ataatccctc cctcaagagt
      301 cgagtcagca tttcaacaga catgtccaag aaccaatttt ccctgaaact gacctctgtg
      361 accgccgcgg acaccgccgt ctattactgt gcgagatatg agggggcggc agctggaacc
      421 tggttctttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002660             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7817:7163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002660
VERSION     KCXD01002660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7817:7163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..481
     V_segment       100..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61142.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       398..402
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           95 a          147 c          134 g          107 t
ORIGIN      
        1 acatggggtt ctctgagagt cacagacatc ctgtgcagga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg atcttgtccc aggtgctact gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccctcagca cttactactg gagctggatc cgccaggccc cagggaaggg gctggagtgg
      241 attggataca tctatgctga tagtgggacc accaactaca acccgtccct caagagtcga
      301 gtcaccattt cagtagacac gtccaagaac ctgtactccc tgaatctgag ctctgtgacc
      361 gccgcggaca cggccttcta ttactgtgcg agacgtccta ctcgcacgcg ggttctatat
      421 gaggcgacag gggaagactt tgactcctgg ggccagggac tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01002661             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21713:4021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002661
VERSION     KCXD01002661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21713:4021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61143.1"
                     /translation="CVRYEDESINYHFDNW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          139 c          125 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tccaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacaac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002662             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21477:5329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002662
VERSION     KCXD01002662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21477:5329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61144.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          115 c          151 g          118 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggac tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaagtc tgtgaaggac cgattcacca tattaagaga
      361 caattccaac agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002663             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5242:8324
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002663
VERSION     KCXD01002663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5242:8324"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61145.1"
                     /translation="CTRRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          113 c          149 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aattggtgga gtctggagga ggtttgggtc
      181 agcctggggg gtccctgaga ctctcctgtg aagcttctgg attcatcttc agtaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattctaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtatttctg tacgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002664             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:28144:11262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002664
VERSION     KCXD01002664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:28144:11262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61146.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          115 a          120 c          146 g          133 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgtgga gcagctggtg gaatctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct caattcacct tcagttccta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtctg gagtgggttt ccggtattaa
      301 cattggcggt gacacatact acccagactc tgtgaagggt cgattcacta tctccagaga
      361 caatgccaag aactccttgt atcttcaaat gaacagcctg agagttgagg acactgctgt
      421 gtatttttgt acaaggggga tagataacta ccactttagt aatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002665             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16779:3713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002665
VERSION     KCXD01002665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16779:3713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61147.1"
                     /translation="CARYDADSVDYYLDLW"
     D_segment       402..409
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           90 a          142 c          127 g          106 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggcgcc
      181 tccatcagca atagcttctg gaactggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggtcga tctatgggag tactgggacc acaagctaca tcccctccct caacagtcga
      301 gtcactattt caacagacac gtccaagaac cagttttccc tgaagctgac ctctgtgacc
      361 gtcgcggaca ccgccgtcta ttactgtgcg agatatgatg ctgatagtgt cgattactac
      421 cttgacctct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002666             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14707:16957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002666
VERSION     KCXD01002666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14707:16957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..490
     V_segment       100..393
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61148.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       412..434
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT           97 a          141 c          139 g          115 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctgc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgtgatgt ctctggtgcc
      181 tccatcagta cttcctggtg gacctggatc cgccagcccc cagggagggg actggagtgg
      241 attggggaga tcaatggtta tagtggtagt ttttactcca acccctccct caacagtcga
      301 gtcaccattt caaaagacgc gtccaagaac cagttcgccc tgaaactgag ctctgtgacc
      361 gccgcggaca cggccgtata ttactgtgcg cgagatgccg ggtttgggga aacgatatta
      421 gtagtcgata ttaatatgtt cccccacttt gactcctggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002667             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6940:7182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002667
VERSION     KCXD01002667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6940:7182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61149.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          136 c          137 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcactg tctctggtgg
      181 ctccttcagt ggttactact ggacctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatg tcaagagaca cgtccaagaa tcaattctcc ctgaagatga cctctatgac
      361 cgccgcggac acggccgttt atttctgtgc cagagatgcg ggagtgggag ccacaatcct
      421 ttactactat gactactggg gccagggagt ccgggtcacc gtctcctcag cc
//
LOCUS       KCXD01002668             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:12477:11739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002668
VERSION     KCXD01002668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:12477:11739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    80..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        80..446
     V_segment       80..373
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <365..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61150.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       384..396
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           96 a          108 c          136 g          108 t
ORIGIN      
        1 acatggggac agaagactca tcatggagtt tggcctgagc tgggttttcc ttgctgctat
       61 tttaaaaggt gtccagggtg aggtgcagct ggtggaatct gggggcggct tggcaaagcc
      121 tggggggtcc ctgagactct cctgtgcagc ctctggattc accctcagta actactggat
      181 gtactgggtt cgccaggcac cagggaaggg gctggagtgg atctcagcta ttaacagtgt
      241 tggtgatacc acatactatg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      301 cgccaagaac actctgtatc ttcaaatgga cagcctgaga gctgaggaca cggctatcta
      361 ttactgtgcg agagttccgg gcctagtggt atttaccggt tcgcttgact actggggcca
      421 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002669             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24195:18106
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002669
VERSION     KCXD01002669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24195:18106"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61151.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       403..409
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           86 a          144 c          132 g           98 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tttctggtgg
      181 ctccatcagc agtgacttct ggagctggat ccgccagccc cccgggaagg gactggagtg
      241 gattggacgt gtctatggta gcactgatag caccagctac aacccctccc tcacgagtcg
      301 agtcaccatt tcaatagaca cgtccaagaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgttt attactgtgc gagagatgcg ggaactggga ccccctttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002670             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21615:10602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002670
VERSION     KCXD01002670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21615:10602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61152.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       414..423
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          144 c          136 g           99 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agtcctcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc ggtagttact ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gaaatagcgg tagtacctac tacagcccct ccctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccaccac tccctgaagc tgaactctgt
      361 gaccaccgcg gacacggccg tgtatttctg tgcgaacgtc ttaggcccct ggggcagctg
      421 gtcacactac tttgagtact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002671             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18597:20032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002671
VERSION     KCXD01002671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18597:20032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61153.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          117 c          152 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagcttggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtt catctggtgg agtctggagg agacttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagtctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc agtgacgtcc
      301 tatgatggaa gttggaacta ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agagcctgct atatcttcaa atggacaacc tgaacttgga ggacacggcc
      421 gtatattact gtgcgagagg ggaatacagt aactctattg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002672             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22407:14255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002672
VERSION     KCXD01002672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22407:14255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..341
     V_segment       5..271
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <263..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61154.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       275..282
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           74 a           99 c           91 g           79 t
ORIGIN      
        1 acatgggctg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct ctggtgactc
       61 catcagcaat agctactgga actggatccg ccagccccca gggaagggac tggagtggat
      121 tgggtatatc tctggtgctt atgggagcac cagctacaac cccgccctca agagtcgagt
      181 caccatttca acagacaagt ccaagaacca gttttccctg aggctgagtt ctgtgaccgc
      241 cgcggacacc gccgtgtatt attgtgtgag atatgaggat gaatccatta actaccactt
      301 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002673             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11893:5441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002673
VERSION     KCXD01002673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11893:5441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..336
     V_segment       6..275
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <267..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61155.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       284..290
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           82 a           78 c           99 g           79 t
ORIGIN      
        1 acatgggagg cttggttcag cctggggggt ccctgagact ctcctgtgca gcctctggat
       61 tcaccttcag tagttatggc atgcactggg tccgccaggc tccagggaag gggctggagt
      121 gggtgacagt tatatcgtat gatgtaagta agaaatacta cgcagacgct gtgaaggacc
      181 gattcaccat ctccagagac aattccaaga acatgctata tcttcaaatg aacaacctga
      241 aattggagga cacggccgtg tattactgtg ggagagatga taatggggtg cttatcgact
      301 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002674             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21342:15060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002674
VERSION     KCXD01002674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21342:15060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61156.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          112 c          146 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 attgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgct aactctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002675             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9778:4117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002675
VERSION     KCXD01002675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9778:4117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61157.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          116 c          155 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtcgc
      121 tattttaaga ggtgtccagt gtgaggttca tctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agtctctgga ttcaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tgacatcgta
      301 tgatggaagt tggaggtact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag agcctgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002676             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:10405:6563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002676
VERSION     KCXD01002676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:10405:6563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61158.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          110 a          144 c          135 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gagatgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccgtc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtc tattactgcg cgattggccc tagtggcagg
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002677             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24629:5402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002677
VERSION     KCXD01002677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24629:5402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61159.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           88 a          138 c          132 g          101 t
ORIGIN      
        1 acatggggat gttctctggg agtcacggac ctcctgggca agaacatgca gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcat tgtctctggt
      181 ggctccatca gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 cagtggattg gccatatcta cgatagtagt ggtaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaat agacacgtcc aagaaccagt tctccctgaa ggtgacctct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002678             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10304:9762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002678
VERSION     KCXD01002678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10304:9762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61160.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          110 c          146 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccaatcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaattgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggaccct gaggctctcc tgtgcagcct ctggattcac cttcagtaat tatggcttgc
      241 actgggtccg ccaggctcca gtgaaggggc tggagtgggt tgcagttata tcgtatgatg
      301 aaaatgtgaa attctacgca gactctgtaa aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002679             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24309:18996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002679
VERSION     KCXD01002679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24309:18996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61161.1"
                     /translation="CAAQIHSGGWSGRFDVW"
     D_segment       431..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          135 c          148 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcctggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atatgccttc acagaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggca ggtgttgatt ctgaatatgg tgaaatgatt
      301 gacgcggaga cgttccagga cagagtcacc atgaccgacg acacgtctac agagacagcc
      361 tacatggagt tgagtagcct gagatctgag gacacggccg tgtattactg tgcggcccaa
      421 attcatagtg gcggctggtc tgggcggttc gatgtctggg gcccgggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002680             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8125:17610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002680
VERSION     KCXD01002680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8125:17610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61162.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          137 c          137 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggccctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcac tgtctctggt
      181 ggctccttca gtggttacta ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggattgggt ttgtcggtgg tggtagtggg accaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtccaag aatcaattct ccctgaagct gacctctatg
      361 accgccgcgg acacggccgt ttattactgt gcgagagatg cgggagtggg agccacaatc
      421 ctttactact atgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002681             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11006:16113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002681
VERSION     KCXD01002681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11006:16113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..481
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61163.1"
                     /translation="CARYEEGGNTFDYW"
     D_segment       433..439
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           96 a          142 c          140 g          105 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa tgctctctga gagtcatgga cctcctgtgc
       61 aggaacatga agcacctgtg gttcttcctt ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc acctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 cttacctgcg ctgtctctgg tgactccatc accagtagct actggggctg gatccgccag
      241 cccccaggga agggactgga gtggattgga tatatctatg gtggtagtgg gagcaccggc
      301 tacaatccct ccctcaagac tcgagtcacc atttcaccgg acacgtccaa gaaccagttt
      361 tccctgaagc tgaagtctgt gaccgccgcg gacaccgccg tatatttctg cgcgcgatat
      421 gaagagggcg gaaacacctt tgactactgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01002682             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20537:2593
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002682
VERSION     KCXD01002682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20537:2593"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61164.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          143 c          128 g           93 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtagactc
      301 catacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggacctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002683             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17149:24203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002683
VERSION     KCXD01002683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17149:24203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61165.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       429..433
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          106 a          116 c          148 g          120 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctgggga
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt ctgatggaag
      301 taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag acaactccaa
      361 gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg tgtatttctg
      421 tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002684             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17016:18425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002684
VERSION     KCXD01002684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17016:18425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61166.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          144 c          137 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacgcagaaa aattccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggagc tgatcagtct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca cctggctata ttggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01002685             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15898:6825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002685
VERSION     KCXD01002685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15898:6825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61167.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       425..432
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          111 a          143 c          150 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccgct
      121 ctgaggtcca actggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga gacaccttca ccgacttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgaccc tgcaaatggt gaaataatac
      301 acgcagatag tttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcggcctg cgatctgagg acacggccgt ttattactgt gcgagagggg
      421 gcttcggtag cagtgtctgg tccaatctcg tctatggttt ggattcctgg ggccaagggg
      481 tcgccgtcac cgtctcctca gcc
//
LOCUS       KCXD01002686             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9412:11905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002686
VERSION     KCXD01002686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9412:11905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61168.1"
                     /translation="CARDKGYSAVRRFDVW"
     D_segment       404..410
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           89 a          143 c          132 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggaaac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactcct ggaactggat ccgccagccc ccgggaaagg gactggagtg
      241 gattggccgt atctctggtc ttagtgggag caccaactac aacccctccc tcacgagtcg
      301 agtcactata tcaacagaca cgtccaagat ccagttctcc ctgatactga actctgtgac
      361 cgccgcggac acggccgttt attactgtgc gagagataag ggttacagtg cagttcgacg
      421 gttcgatgtc tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002687             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14678:13147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002687
VERSION     KCXD01002687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14678:13147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..451
     V_segment       88..381
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61169.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       391..397
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..451
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           92 a          107 c          144 g          110 t
ORIGIN      
        1 acatggggag cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt
       61 gttgctcttt tgaaaggtgt ccagtgtgag gtgcagctgg tggagtcggg gggcggcttg
      121 gcaaagcctg gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttac
      181 tacttcatga gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt
      241 aatagtggtg gggatgatac atactatgca gactccgtga agggccgatt caccttgtcc
      301 agagagaacg ccaagaacac actgtatctt cacatggtca gcctgagagg tgaggacacg
      361 gctgtctatt actgtgcgag agaccgacgt gtacagtcgt tatcctggtt cgatgtctgg
      421 ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002688             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20813:10675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002688
VERSION     KCXD01002688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20813:10675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..498
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61170.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       441..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          147 g          125 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtacaat tggtggagtc tggaggaggt ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag tttctggatt caccttcagt aactatgcca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgtaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attctaacaa catgctatat cttcaaatga gcaacctgaa attggaggac acggccgtgt
      421 atttctgtgc gaggcgccct tggaacgctg actactttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002689             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14836:19375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002689
VERSION     KCXD01002689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14836:19375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..500
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61171.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       445..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          111 a          115 c          155 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gtagtctctg gattcacctt caggaattat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 tttgatggaa ttaagagtta ttacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcaa agaacatgct aaatcttcaa atgaacgacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagacg cccttggaac gctgactact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc cgcc
//
LOCUS       KCXD01002690             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23117:14999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002690
VERSION     KCXD01002690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23117:14999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61172.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           94 a          131 c          137 g           99 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctggg caagaacatg aggcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gatgtctctg
      181 ggggctccat cagcagtggt tatggctgga gctggatccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtatc tacgatagta gtggaaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca aaagacacgt ccaagaacca gttctccctg aagatgaggt
      361 ctatgaccgc cgcggacgcg gccgtgtatt attgtgcgag atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002691             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13522:12339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002691
VERSION     KCXD01002691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13522:12339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61173.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       440..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          114 a          122 c          162 g          117 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggtct gacctgggtt ttccttgttg
      121 gtcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggctc
      181 agcctggggg gtccctgaga ctctcctgtg cagcgtctgg gttcaccttc agtagctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gccatatcat
      301 ttgatggaag taagaaaaac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tgtactactg ttcgagggag tggatacagt gggcacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002692             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17375:2615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002692
VERSION     KCXD01002692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17375:2615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61174.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       438..443
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          110 c          154 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga agtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gcttcagtgg ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtatgat
      301 gaaactaaga aatattacgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tgctatattt tcaaatgaac aacctgaaat tggaagacac ggccgtatat
      421 tactgtgcga gagatgtcta tggcagggga cttgacttct ggggcctggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002693             315 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23386:23795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002693
VERSION     KCXD01002693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 315)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 315)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23386:23795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..313
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..313
     V_segment       9..238
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <232..>282
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61175.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       252..258
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       262..313
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        314..>315
                     /gene="IGHG"
BASE COUNT           82 a           82 c           85 g           66 t
ORIGIN      
        1 acatggggct gcaaggtttc cggatacatc ttaaccgaat tatccatgca ctgggtgcga
       61 caggcccctg gagaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      121 atagacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      181 gcctacatgg aactgagcag tctgagatct gaggacacgg ccgtatatta ctgtgcgaca
      241 tcatccagcg gcacctggct atactggtac ttcgatatct ggggccctgg caccccaatc
      301 accatctcct cagcc
//
LOCUS       KCXD01002694             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17621:8303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002694
VERSION     KCXD01002694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17621:8303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..490
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61176.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       432..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>497
                     /gene="IGHG"
BASE COUNT          114 a          139 c          142 g          102 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcctggt ggcggcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatgcac tggctgcgac
      241 aggcccctgg aaaagggctt gagtggttgg gatgtgttga ttataaatat gatgaagaaa
      301 tatacgcaga caatttccag ggcagagtca ccatgaccga ggacacgtcc acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcggcgg
      421 gccttggggg atatttactg cttactgaat atttccagtt ctggggccag ggcgccctgg
      481 tcaccgtctc ttccgcc
//
LOCUS       KCXD01002695             342 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:14719:5403
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002695
VERSION     KCXD01002695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 342)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 342)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:14719:5403"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..340
     V_segment       7..265
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <259..>309
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61177.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       283..291
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..340
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>342
                     /gene="IGHG"
BASE COUNT           78 a           91 c          104 g           69 t
ORIGIN      
        1 acatgggggg ctgaggtgat gcagcctggg gcctcagtga aggtctcctg caaggtttcc
       61 ggaaacacct tcaccgaatt gtccatgcac tgggtgcgac aggcccctgg aaaagggctt
      121 gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga cgttccaggg tagagtcacc
      181 atgaccgagg acacgtctac agacacagcc tacatggaac tgagcagcct gacatctgag
      241 gacacggccg tgtattactg cgcgattggc cctagtggca gatggaacga ctggtccttc
      301 gacatctggg gacctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01002696             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18605:9444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002696
VERSION     KCXD01002696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18605:9444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61178.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          111 a          122 c          154 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcaa ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaatcat
      301 ggtggggaaa gtacatacta tgcagactcc gtgaagggca gattcaccct ctccagagag
      361 aacgccaaga acacactata tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002697             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11519:10243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002697
VERSION     KCXD01002697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11519:10243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61179.1"
                     /translation="CARRPLPYEDDYSYYLGIFDYW"
     D_segment       410..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           99 a          134 c          140 g          114 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtgattatg gctggaactg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtatttatg gtagtagtgg taacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagaaga ccgcttccct acgaggatga
      421 ttacagttat tatttgggga tctttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01002698             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16454:23507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002698
VERSION     KCXD01002698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16454:23507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61180.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           93 a          149 c          132 g          113 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaaac cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactcc cacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagctt tccccctacg actatttttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01002699             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:24495:7357
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002699
VERSION     KCXD01002699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:24495:7357"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61181.1"
                     /translation="CARDVRGTGFDFW"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          115 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 cgcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggcca
      421 tatattactg tgcgagagat gtcaggggca cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002700             354 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13464:13920
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002700
VERSION     KCXD01002700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 354)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 354)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13464:13920"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..352
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..352
     V_segment       7..277
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>321
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61182.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       291..297
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..352
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        353..>354
                     /gene="IGHG"
BASE COUNT           90 a           89 c          101 g           74 t
ORIGIN      
        1 acatgggggg ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg caaggtttcc
       61 ggatacatct taaccgaatt atccatacac tgggtgcgac aggcccctgg aaaagggctt
      121 gagtggatgg gaagtgttga tcctcaatat ggtgaaatga tagacgcaga gaaattccag
      181 ggcagagtca ccatgaccga ggacacgtct acagacacag cctacatgga gctgagtagt
      241 ctgagatctg aggacacggc cgtgtattac tgtgcgacat catccagcgg cacctggcta
      301 tactggtact tcgatatctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01002701             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10712:21146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002701
VERSION     KCXD01002701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10712:21146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61183.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       421..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          114 a          144 c          133 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cgcagcacct
       61 caccatggac tggacctgga ggatcctcct cttagtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcag cgatttatcc atacactgga tacgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcttttggtg aaatgataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcttcag acacagcctt
      361 catggaattg agcagcctga aatctgacga cacggccgtg tatttctgtg cgagtggccc
      421 tagcggcacc tggatcgact ggtccttcga tgtctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01002702             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16161:15730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002702
VERSION     KCXD01002702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16161:15730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61184.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          139 c          135 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002703             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11909:11848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002703
VERSION     KCXD01002703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11909:11848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61185.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       435..439
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          106 a          119 c          150 g          121 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttcctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggagtcc ctgagactct cctgtgcagc ctctggattc cccttcagta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtgtctgtaa tttcgtctga
      301 tgaaagtaag aaatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ctccaagaac atactatttc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 tttctgtgtg agagatgcct tcgggggcgg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002704             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13210:11853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002704
VERSION     KCXD01002704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13210:11853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..510
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61186.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       456..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>514
                     /gene="IGHG"
BASE COUNT          103 a          130 c          159 g          122 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaagggg actggagtgg gtctcatcca ttaggaacac
      301 tggtaaaatc gtatactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcgctgtctc tgcgaatgac cagtctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaattggcg tcggatctct ggcaacggct ggtgactact ttgaccactg
      481 gggccaggga gtcctggtca ccgtctcctc cgcc
//
LOCUS       KCXD01002705             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11241:13379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002705
VERSION     KCXD01002705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11241:13379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61187.1"
                     /translation="CAIGPSGRWNAWSFDIW"
     D_segment       406..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          104 a          142 c          137 g           92 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca gcttcaccga attgtccatg cactgggtgc gacaggcccc
      241 tggaagaggc cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgacgttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag
      361 cctgagatct gaggacacgg ccgtatatta ctgtgcgatc ggccctagcg gcaggtggaa
      421 cgcctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01002706             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17243:8017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002706
VERSION     KCXD01002706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17243:8017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61188.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       436..447
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          104 a          129 c          156 g          112 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagcactgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg ggggcggctt ggcaaagcct
      181 gggggatccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctatgctata
      241 cactgggtcc gccaggctcc cgggaagggg ctggagtggg tctcagccat tagtagtggt
      301 ggtagcacat actacgcaga ctccatgaag ggccgagcca ccatctccag agacaactca
      361 aagaacacgg tctccctgca agtgaacagc ctgacttctg aggacacggc cgtgttttac
      421 tgtgcgagag gggagacagc ttcagtttac tacgctttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01002707             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12098:6849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002707
VERSION     KCXD01002707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12098:6849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61189.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          109 a          146 c          135 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaagt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caggatttcc ggatacacct tcaccgaatt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctgtat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacttggaac
      361 tgagcggcct gacttctgag gacacggccg tgtattactg tgcgactggc cctaccggca
      421 cctggaacgc ctggtacctc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01002708             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8443:14440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002708
VERSION     KCXD01002708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8443:14440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61190.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       425..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          142 c          133 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggcccag ctggtgcagt ctggggcgga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acatcttcac cgaattatcg ttccactggg tgcgccaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgataca
      301 cacagagaaa ttccagggca gaatcaccat gaccgaggac acgtccacag acacagccta
      361 catggaactg agcagcctga gatctgagga cacggccgtg tatttctgtg cgatatcatc
      421 cagtggcagc tggctattct ggtatttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01002709             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:8581:7890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002709
VERSION     KCXD01002709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:8581:7890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61191.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       448..462
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          104 a          121 c          159 g          128 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acgcagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtccgggggc ggcttggcag
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtaactact
      241 ggatgtactg ggttcgccag gcaccaggga aggggctgga gtggatctca gctattaata
      301 gcgctgatag tggcacatac tatgcagact ccgtgaaggg cagattcacc atttccaggg
      361 acaacgccag gaacacactg tttcttcaaa tggacagcct gagagttgag gacacggctg
      421 tctattactg tgcgagagta ccgggcctag tggtttttac tggttccctt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002710             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20310:9445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002710
VERSION     KCXD01002710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20310:9445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61192.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          123 c          151 g          117 t
ORIGIN      
        1 acatgggggc tctgggacag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttccccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tcatttcgta
      301 cgacgaaact aagaaatact acgcagactc tctggaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcagat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgcggaggc cctggagtgc agatgccttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01002711             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8814:12309
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002711
VERSION     KCXD01002711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8814:12309"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61193.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       406..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          142 c          129 g          109 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtgtc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccagtagctt ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ctatctatgg tgctactggg agcaccacct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgagact gagctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgacgatga ttacggttcc
      421 tattaccttg actactgggg ccagggagtc ctggtccccg tctcgtcagc c
//
LOCUS       KCXD01002712             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:13685:17489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002712
VERSION     KCXD01002712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:13685:17489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..468
     V_segment       108..401
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61194.1"
                     /translation="CTRVRGVTIHYFDYW"
     D_segment       411..417
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           91 a          136 c          140 g          103 t
ORIGIN      
        1 acatgggggg gaaatgctct ctgagagtca cggacatcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagttc ccagatgggt cctgtcccag gtgcagctgc
      121 aggagtcggg cccaggactt gtgaagcctt cggagaccct gtccctcacc tgcgctgtct
      181 ctggtggctc cttcagcggt tactactggg gctggatccg ccagccccca ggggagggac
      241 tggagtggat tgggtatatc agtgggagtg gtgggagtac cgactacaag tcctccctca
      301 agagtcgagt caccatttca acagacacgt ccaagaacca gttctccctg aagctgagct
      361 ctgtgaccgc cgcggacacg gccgtatatt actgtacgag agtccggggc gtaactatcc
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002713             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20015:12964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002713
VERSION     KCXD01002713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20015:12964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61195.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          128 c          139 g          111 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg atttaccttc gacaaatatg gaatcaactg ggtgcggcag
      241 gcccctggac aagggcttga gtggatggga gtggtcatcc cccttgttgg tattatcaat
      301 tatgcagaga acttccaggg cagaataatg attaacgcgg acacgtccat aaacacagcc
      361 ttcatggagt tcaggagcct gagatctgac gacacggcca tttatttctg tgcgagagaa
      421 tactgtacaa ctactgattg cgccgggttc tttgactact ggggccaggg agtcacggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002714             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:6356:13621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002714
VERSION     KCXD01002714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:6356:13621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61196.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          120 c          151 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttcg
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg atgctggagg acacggccgt
      421 ctattactgt gcgagagacg catatggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002715             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15238:6422
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002715
VERSION     KCXD01002715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15238:6422"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61197.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       415..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          116 a          146 c          133 g           94 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc atagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagcaacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gaattatcca ttcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggc gttgatcctg catatggtga gtttacaccc
      301 ggagagaagc tccagggcag agtcaccatg accgaagaca cgtctataga cacagcctac
      361 atggagctga gcagcctgaa ttctgacgac acggccgtct attactgtgc tgccgggtat
      421 agcggcagct ggaaccactg gtacttcgat ctctggggcc ctgacacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01002716             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17639:8270
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002716
VERSION     KCXD01002716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17639:8270"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61198.1"
                     /translation="CARVWGGSYYFYYFDYW"
     D_segment       405..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           90 a          133 c          138 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tacaggagtc
      121 gggcccagca gtggtgaagc cctcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtattaact ggtggagctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg ggtctctatg gtagtgatgg gaggaccgaa tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccaattc tccctgagtc tgagctctgt
      361 gaccgccgcg gactccgccg tgtattattg tgcgagagtt tggggtggta gttattactt
      421 ttactacttt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002717             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18699:9512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002717
VERSION     KCXD01002717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18699:9512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61199.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       437..443
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          120 c          146 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt catcttcagt aactatgcca
      241 tgcactgggt ccgccaggct ccagggaagg ggctagagtg ggtggcagtt atttcgcatg
      301 atggaactaa gaaatactac acagactctg cgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catacaatat cttcacatga acagcctgaa attggaggac acggccatat
      421 actactgtgc ggcctcctac ttggggtacg gttttgagta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002718             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:11372:12349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002718
VERSION     KCXD01002718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:11372:12349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..396
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61200.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       405..411
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..472
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          105 a          147 c          130 g           92 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccttctgg tgcagtctgg ggctgaggtg atgcagcccg gggcctcagt gaaggtctcc
      181 tgcaaggtct ccggaaacac cttcaccgaa ttgtccatac actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtgggt gggaagtgtt gatcccgcat atggtgaaat gacgttccag
      301 ggcagagtca tcatgaccga ggacacgtct acagacacag cctacatgga actgaccagc
      361 ctgacatctg acgacacggc cgtctattac tgtgcggttg gccctagtgg cacttggaac
      421 cactggtcct tcgatatctg gggccctggc accccagtca ccatctcctc agcc
//
LOCUS       KCXD01002719             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8181:8156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002719
VERSION     KCXD01002719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8181:8156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..516
     V_segment       153..444
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61201.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       461..471
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT           99 a          157 c          140 g          122 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg ccgaggtgca gctggtgcag tctggagcag
      181 aggtgaaaag gcccggggaa tctctgagga tctcctgtaa gacttctgga tacagcttta
      241 ccgattactg gatcagttgg gtgcgccaga tgcccgggaa aggcctggag tggatgggaa
      301 tgatctatcc tagtgattct gatcccagat acagcccgtc cttccaaggc caggtcacca
      361 tctcagccga caggtccatc agcaccgcct acctggagtg gggcagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagagctg gacgctacac ctacagttac ccctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002720             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12931:17836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002720
VERSION     KCXD01002720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12931:17836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..341
     V_segment       7..279
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61202.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       286..297
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           68 a          102 c          101 g           72 t
ORIGIN      
        1 acatgggggc ccaggactgg tgaagccttc ggagaccctg tctgtcacct gcgctgtctc
       61 tggtggctct atcagcattt actactggaa ttggatccgc caggccccag ggaagggact
      121 ggactggatt ggacatatct atgggagcgg tggtagcacc aactacaacc cctccctcaa
      181 gagtcgagtc accctgtcag tagacacgtc caagaaccag ttctccctga acctgaggtc
      241 tgtgaccgcc gcggacacgg ccgtatatta ctgtgcgagc ggtcggcggc agctggactt
      301 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002721             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24761:12924
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002721
VERSION     KCXD01002721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24761:12924"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61203.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       413..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          106 a          145 c          138 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggccccagg aagaggcctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tatattactg tgcgatcggc cctagcggca
      421 gttggaacgc ctggtccttc gatatctggg gccctggcac cccaatcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01002722             373 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:24194:10710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002722
VERSION     KCXD01002722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 373)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 373)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:24194:10710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    17..371
                     /note="immunoglobulin heavy chain variable region"
     V_region        17..371
     V_segment       17..310
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <302..>340
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61204.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       314..326
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       330..371
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        372..>373
                     /gene="IGHG"
BASE COUNT           83 a           85 c          119 g           86 t
ORIGIN      
        1 acatggggtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
       61 ggggtccctg agactctcct gtgcagtctc tggattcacc ttcagtagct ttggcatgca
      121 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagtgacat cgtatgatgg
      181 aagttggaag tactacggag actctgtgag ggaccgattc accatctcca gagacaattc
      241 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtatatta
      301 ctgtgcgaga ggggaataca gtaactctgt tgactactgg ggccagggag tcctggtcac
      361 cgtctcctca gcc
//
LOCUS       KCXD01002723             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21213:7538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002723
VERSION     KCXD01002723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21213:7538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..478
     V_segment       115..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61205.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       406..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          115 a          137 c          133 g           95 t
ORIGIN      
        1 acatggggaa caaccacatc cctcccctac agaagcccca gagcatagca cctcaccatg
       61 gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca ctctgaggtc
      121 caggtggtgc agtctggggc tgaggtgaag gagcctgggg cctcagcgaa ggtctcctgc
      181 aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca ggcccctgga
      241 aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa acacacagag
      301 ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta catggagttg
      361 agcagcctaa gatctgagga cacggccctg tattattgtg cagtcgggta tagcggccga
      421 tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002724             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:22680:11595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002724
VERSION     KCXD01002724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:22680:11595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61206.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       445..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          114 c          153 g          117 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tacctatggc
      241 attcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtat
      301 gatgaaacta agacatacta cgcagactct gtgagggacc gattcaccat ctccagagac
      361 aattccaaaa acatggtgta tcttcaaatg aacaacctga aattggagga cacggccata
      421 tattactgtg cgagagatgt caggggaacg gggtttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01002725             402 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:8628:11157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002725
VERSION     KCXD01002725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 402)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 402)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:8628:11157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    46..400
                     /note="immunoglobulin heavy chain variable region"
     V_region        46..400
     V_segment       46..339
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <331..>369
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61207.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       349..354
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       358..400
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        401..>402
                     /gene="IGHG"
BASE COUNT           91 a           86 c          122 g          103 t
ORIGIN      
        1 acatgggggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt acagctggtg
       61 gagtctggag gagacttggt tcaccctggg gggtccctga gactctcctg tgcagcctct
      121 ggattcacct tcagtaactt tggcatacac tgggtccgcc agggtccagg gaaggggctg
      181 gagtgggtgg cagttatatc gtatgatgaa actaggacat actacgcaga ctctgtgaag
      241 gaccgattca ccatctccag agacaatttc aagaacatga tatttcttca aatgaacaac
      301 ctgaaattgg aggacacggc cgtgtattat tgtgtgagag atgtcagggg aacggggttt
      361 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002726             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:9029:6824
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002726
VERSION     KCXD01002726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:9029:6824"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..494
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61208.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       414..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          111 a          135 c          143 g          111 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg ctacaccttc agcatctctt ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttgg gtggatagga gggatcatcc ctcttgttgg tatgacaaac tacgaacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc ttcatggaaa
      361 tgagcagcct gagatttgag gacacggccg tctactattg tgcgacaggg gtatattacc
      421 aggatgaata cggttatttt tatgtcggcg gtgactttga ctactgggac cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01002727             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13255:12611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002727
VERSION     KCXD01002727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13255:12611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61209.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           97 a          134 c          136 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactatt ggagctggat tcgccagccc ccagggaagg gactggaatg
      241 gattgggtat attagtgcca gtactgggag caccgactac aacccctcct tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaggctga cgtctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggtccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002728             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14829:7408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002728
VERSION     KCXD01002728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14829:7408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..507
     V_segment       135..428
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61210.1"
                     /translation="CTRIGVGSLATAGEYFDYW"
     D_segment       445..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          107 a          128 c          156 g          118 t
ORIGIN      
        1 acatgggggg agacaggagc cttagccctg gattccaaga acttccactt tgggatcagc
       61 tctgaacaca gaggaccatg gagttggggc tgagctggct tttccttgtt gctattttaa
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc cagcctgggg
      181 ggtccctcag actctcctgt gcagcctctg gattcacctt tggtgattat ggcatgcact
      241 gggtccgcca ggctccggga aagggactgg agtgggtcgc atccattaga aacactggga
      301 aacccgtata ctacgctgac tccgtgaagg gccgattcac catctccaga gacaacgcca
      361 agaactcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc gtgtattact
      421 gtactagaat tggcgtcgga tctttagcaa cggctggtga atactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002729             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22428:20290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002729
VERSION     KCXD01002729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22428:20290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61211.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          140 c          136 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcga caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat attggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002730             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5769:4419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002730
VERSION     KCXD01002730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5769:4419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61212.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          121 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tctcttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaggttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaatag
      301 tggtgggcaa attacatact atgcagagtc cgtgcagggc agattcacca tctccagaga
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002731             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19472:4311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002731
VERSION     KCXD01002731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19472:4311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..506
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61213.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       437..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..506
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          120 a          120 c          148 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcacctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagct atggcatgca
      241 ctgggtccgc cagtctccag gggaggggct ggaatgggtg gcacttatat cgtatgatgg
      301 aactaagaaa tactacgcag actctatgaa ggaccgattc accatctcca gagacaattc
      361 caagaacata ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gtaagcggta taactgaaag ttccgttgaa tacttcgagt tctggggcca
      481 gggcgccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002732             370 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16380:16802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002732
VERSION     KCXD01002732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 370)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 370)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16380:16802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    14..368
                     /note="immunoglobulin heavy chain variable region"
     V_region        14..368
     V_segment       14..293
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <287..>337
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61214.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       308..319
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       320..368
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        369..>370
                     /gene="IGHG"
BASE COUNT           80 a           96 c          114 g           80 t
ORIGIN      
        1 acatgggcac tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc
       61 ctcagtgaag gtctcctgca aggtttccgg aagaaccttc accgaattat ccatgcactg
      121 ggtgcgacag gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg
      181 tgaaatgatg ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      241 catggagctg agcagcctga gatctgagga cacggccgtc tattactgtg cgattggccc
      301 tagtggcagc tggaacgact ggtccttcga catttgggga cctggcaccc caatcaccgt
      361 ctcctcagcc
//
LOCUS       KCXD01002733             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19525:12389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002733
VERSION     KCXD01002733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19525:12389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..423
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61215.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       434..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          102 a          124 c          152 g          113 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 taaacacaga acacaccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca ttgtgaggtg cagctggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctaag actctcctgt gaagcctccg ggttcacctt cagtgaccac tgcatacact
      241 gggtccgcca ggcttcaggg aaggggctgg agtgggtctc aggtattact tatactggtg
      301 ttaccacatg gtacgcagac tccgtgaggg gcagattcac catctccaga gagaacacca
      361 agaacacact gtatcttcaa atggacagcc tgagagctga ggacacggct gtctatttct
      421 gtgtggcagg aaggcggcac gtggaccttg actactgggg ccagggagtc ctggtcgccg
      481 tctcctcagc c
//
LOCUS       KCXD01002734             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7326:17173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002734
VERSION     KCXD01002734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7326:17173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61216.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       443..450
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          117 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcataga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agcaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaag taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaaatggag gacacggccg
      421 tttattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01002735             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11697:17967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002735
VERSION     KCXD01002735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11697:17967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61217.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       400..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           91 a          135 c          128 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccaaatg ggtcctgtcc cagctacaat tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc atttactact ggaattggat ccgccaggcc ccagggaagg gactggactg
      241 gattggacat atctatgtta gcggtgatag caccaacttc aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagttctcc ctgaacctga ggtctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagcggtcgg cggcagctgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002736             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8549:17403
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002736
VERSION     KCXD01002736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8549:17403"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61218.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          109 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      301 ttgatgaaag taagaaatac tacgtagatt ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002737             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17131:21066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002737
VERSION     KCXD01002737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17131:21066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61219.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          112 c          155 g          117 t
ORIGIN      
        1 acatggggag gtctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctggg gtgggtggca gttatatcgt
      301 atgatgaaac taagaaattc tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002738             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15396:5674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002738
VERSION     KCXD01002738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15396:5674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..473
     V_segment       107..398
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61220.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       404..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          140 c          132 g          110 t
ORIGIN      
        1 acatgggggc tgtctgagag tcagggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag gtcccagatg ggtcctgtcc cagccgcagc tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcgact gcgttgtctc
      181 tggtggctcc atcagcgatt actcctggag ctggatccgc cagcccccag ggaagggact
      241 ggagtggatt gggaatattg atgttcatct tgcgggcccc aactacaacc cctccctcaa
      301 gagtcgagtc gccatttcaa aagacacgtc caagaatcag ttctccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtatattt ctgtgcgaaa caatatagtg gtagttatta
      421 ctattcccac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002739             342 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14636:7672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002739
VERSION     KCXD01002739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 342)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 342)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14636:7672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..340
     V_segment       7..279
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>309
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61221.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       289..294
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..340
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>342
                     /gene="IGHG"
BASE COUNT           81 a           82 c          102 g           77 t
ORIGIN      
        1 acatggggag gaggcttggt tcagcctggg gggtccctga gactctcctg tgcagcctct
       61 ggattcacct tcagcacctt tggcatacac tgggtccgcc aggctccagg gaaggggctg
      121 gagtgggtgg ctgttatatc gtatgatgaa actaagaaat actacggaga ctctgtgagg
      181 gaccgattca ccatctccag agacaattcc aaaaacatgg tatatcttca aatgaacaac
      241 ctgaaattgg aggacacggc cgtatattac tgtgcgagag acgtcagggg aacggggttt
      301 gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002740             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20186:10366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002740
VERSION     KCXD01002740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20186:10366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..492
     V_segment       102..395
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61222.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       414..436
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT           98 a          141 c          140 g          115 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgtgat gtctctggtg
      181 cctccatcag tacttcctgg tggacctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatggt tatagtggta gtttttactc caacccctcc ctcaacagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga accagttcgc cctgaaactg agctctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgcgagatgc cgggtttggg gaaacgatat
      421 tagtagtcga tattaatatg ttcccccact ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002741             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16360:4709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002741
VERSION     KCXD01002741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16360:4709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61223.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          137 c          141 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggccctgga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggggctggat ccgccggccc ccagggaagg ggctggagtg
      241 gattgggtat atcagtggga gtagtgggag caccgactac aagtcctccc tccagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctggagttga gttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgttacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002742             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:26928:9022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002742
VERSION     KCXD01002742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:26928:9022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61224.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          114 c          152 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatggca
      241 ttcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaactaa gacatactac gcagactctg tgagggaccg attcaccatc tccagagaca
      361 attccaaaaa catggtgtat cttcaaatga acaacctgaa attggaggac acggccatat
      421 attactgtgc gagagatgtc aggggaacgg ggtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002743             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8705:11901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002743
VERSION     KCXD01002743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8705:11901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61225.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          113 a          143 c          129 g           91 t
ORIGIN      
        1 acatggggca cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaagc ttctggatac accttaaccg accactacct gcactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggtg ttcatcctga atatggtaaa gtagactaca
      301 cacagaagtt ccgagacaga gtcaccatca ccgcggacat gtcgacagag acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgttta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgacttc tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002744             274 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5529:18248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002744
VERSION     KCXD01002744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 274)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 274)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5529:18248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..272
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..272
     V_segment       8..187
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <179..>241
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61226.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       196..203
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       227..272
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        273..>274
                     /gene="IGHG"
BASE COUNT           60 a           68 c           88 g           58 t
ORIGIN      
        1 acatgggcag gcccctggaa aagggcttga gtggatggga ggtgttgacc ctgcaaatgg
       61 tgaaataata cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac
      121 agacacagcc tacatggagc tgagcggcct gcgatctgag gacacggccg tttattactg
      181 tgcgagaggg ggcttcggta gcagtgtctg gtccaatctc gtctatggtt tggattcctg
      241 gggccaaggg gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01002745             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8489:5264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002745
VERSION     KCXD01002745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8489:5264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61227.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       289..293
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           75 a           87 c          104 g           84 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctgggga gtccctgaga ctctcctgtg
       61 cagcctctgg attccccttc agtacctctg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtgtct gtaatttcgt ctgatgaaag taagaaatac tacgcagact
      181 ctgtgaagga ccgattcacc atctccagag acaactccaa gaacatacta tttcttcaaa
      241 tgaacaacct gaaattggag gacacggccg tgtatttctg tgtgagagat gccttcgggg
      301 gcggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002746             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16577:17731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002746
VERSION     KCXD01002746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16577:17731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61228.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       439..446
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          111 c          148 g          131 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggga ttcccaggtg ttttcattca gagatcagga
       61 ctgaacacac aggactcacc atggagttta tgttgagctg ggttttcctt gttgctatat
      121 taaaaggtgt ccagtgtgtg gagcagttgg tggaatctgg gggaggattg gtacagcctg
      181 gggcgtccct gagactctcc tgtgcagcct ctgaattcac cttcagtagc tttgacatgc
      241 actgggttcg ccaggctcca gggaagggtc tggagtgggt atcaggtatt aacattggcg
      301 gtgacacata ctacccagac tctgtgaagg gtcgattcac tatctccaga gacaatgcca
      361 agaactccgt gtatcttcaa atgaacagcc tgagagttga ggacactgct gtgtattttt
      421 gtgcaagggg gatagataac taccacttta gtaatacgga gtttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002747             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17925:6455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002747
VERSION     KCXD01002747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17925:6455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61229.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       421..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          115 a          143 c          134 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cgcagcacct
       61 caccatggac tggacctgga ggatcctcct cttagtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcag cgatttatcc atacactgga tacgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcttttgggg aaatgataaa
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcttcag acacagcctt
      361 catggaattg agcagcctga aatctgacga cacggccgtg tatttctgtg cgagtggccc
      421 tagcggcacc tggatcgact ggtccttcga tgtctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01002748             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:9264:11170
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002748
VERSION     KCXD01002748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:9264:11170"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61230.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          122 c          154 g          125 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gcactagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002749             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6095:16438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002749
VERSION     KCXD01002749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6095:16438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..501
     V_segment       122..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61231.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       423..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>505
                     /gene="IGHG"
BASE COUNT          117 a          142 c          143 g          103 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag gcttctggat tcaccttcag caccgatgcc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgact ggatgggagg ggtcatccct cttatgggta caacaaacta
      301 cgcacagaag ttccagggca gagtcacgtt taccgcggac acgtccctaa ccacagccta
      361 catggaactg agcagcctga gatctgagga cacggccgtg tattattgtg cgaaatccgt
      421 gaattacgag gaagataacg gttactatat accgacgcag tttgactact ggggccaggg
      481 agtcctggtc accgtctcct ctgcc
//
LOCUS       KCXD01002750             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5023:10476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002750
VERSION     KCXD01002750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5023:10476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61232.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       408..415
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..468
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          150 c          123 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agcatggaca tcctgtacaa gaacatgcgg tatctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcac ctgcaggagt
      121 cgggcccagg actggggaag ccttcagaaa ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag tcgtaactgg tggagttgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtcttggaa gtaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tatttctgtg cgagacattc agaccccgca actactagct
      421 ggtacttcga tctctggggc cccggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002751             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18853:12032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002751
VERSION     KCXD01002751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18853:12032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61233.1"
                     /translation="CVRDAFGSGFDVW"
     D_segment       443..448
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          111 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      301 atgatgaaaa taagaaatac tacgcagact ctgtgaaggg ccgattcacc atctccagag
      361 acaattccaa gaatatgata tatgttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gcatttgggt cggggttcga tgtctggggc ccgggagtcc
      481 tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01002752             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15465:16065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002752
VERSION     KCXD01002752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15465:16065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..490
     V_segment       112..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61234.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       414..421
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          106 a          139 c          149 g           98 t
ORIGIN      
        1 acatgggcaa ccacatccct cccctacaga agccccagag cacagcacct caccatggac
       61 tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccgctc tgaggtccaa
      121 ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag
      181 gtttccggag acaccttcac cgacttatcc atgcactggg tgcgacaggc ccctggaaaa
      241 gggcttgagt ggatgggagg tgttgaccct gcaaatggtg aaataataca cgcagatagt
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcggcctgc gatctgagga cacggccgtt tattactgtg cgagaggggg cttcggtagc
      421 agtgtctggt ccaatctcgt ctatggtttg gattcctggg gccaaggggt cgccgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002753             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15627:16474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002753
VERSION     KCXD01002753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15627:16474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61235.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       423..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          140 c          145 g          105 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagt tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tcctgcaagg ctcctggata catcttcagc atatctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttggtgt aacaacctac
      301 gcacagaagt tccaggacag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagtggcggc
      421 ttcgaggatg ataacggtca ctattatacg acactaacat ttcacgattg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002754             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20466:4391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002754
VERSION     KCXD01002754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20466:4391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61236.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          122 a          142 c          134 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatccac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01002755             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11293:14376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002755
VERSION     KCXD01002755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11293:14376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..486
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61237.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       416..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>490
                     /gene="IGHG"
BASE COUNT          118 a          142 c          131 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gctacagctt cgccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggttttgct agtatatatg gtcaaataat
      301 acatacagag agattccagg gcagagtcac catgacagcg gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgacatctga ggacacggcc gtgtattact gtgcggcagc
      421 tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctccgcc
//
LOCUS       KCXD01002756             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15755:5153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002756
VERSION     KCXD01002756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15755:5153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61238.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       427..434
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          105 a          137 c          146 g          102 t
ORIGIN      
        1 acatggggga tcacataaca accacgtccc tcctctaaag aagcccctgg gaacacagct
       61 catcaccatg gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca
      121 gtcccaggtc cagctggtgc agttcggggc tgatgtgaag aagcctgggg cctcagtgaa
      181 gctctcctgc aaggcttctg gattcgcctt cagaatgtat gccctcagtt gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg agggatcgtc cctcttgttg gaacaacaaa
      301 ctccgcacag aagttccagg gcagagtcac gattaccgcg gacacgtcca caagcacagt
      361 ctacatggag ttgagcagcc tgagatctga ggacacggcc atgtattact gtgcgagagg
      421 cctgggtagc agcgcccact ttggtttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002757             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:9563:4362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002757
VERSION     KCXD01002757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:9563:4362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61239.1"
                     /translation="CARWEAASFDYW"
     D_segment       405..409
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           84 a          131 c          137 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccgtca gcggtggtta tggctggagc tggatccgcc aggccccagg gaagggactg
      241 gagtggattg ggagtatcta tggtcatagt ggtagcaccc gctacaatcc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gttgacctct
      361 gtgaccgccg cggactcggc cgtgtatttc tgtgcgagat gggaagctgc ctcttttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002758             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21012:17648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002758
VERSION     KCXD01002758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21012:17648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61240.1"
                     /translation="CMREASAWSVGGDFW"
     D_segment       413..419
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           86 a          135 c          138 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcagg aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccgtcagt actcactggt ggggctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atttctggta gtggtgggat caccagatac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca catccaacaa ccaattctcc ctgaagctga cctctgtgac
      361 ggccgcggac acggccgtgt atttctgtat gagagaggct agcgcctggt cggtgggagg
      421 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002759             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21621:19002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002759
VERSION     KCXD01002759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21621:19002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61241.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       417..423
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          137 c          146 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccatatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatact gtatctggtg gagagatata
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acggccaaag acacagccta
      361 catggagctg accagcctga gatctgagga cacggccgtt tattactgtg cgagaggtgt
      421 gacggcagac gtcttcggtt tcctcgggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01002760             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22773:14721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002760
VERSION     KCXD01002760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22773:14721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..476
     V_segment       125..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61242.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       408..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          116 a          135 c          135 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcagagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctgatgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggttaccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaaggacttg agtggatggg aagtgttgat cctgtatatg gtgaaatgaa
      301 agagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 tagcctgaga tctgaggata cggccgtgta ttattgtgca gtcggcaata gcggcagctg
      421 gatctcctgg tccttcgatg tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01002761             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22698:16352
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002761
VERSION     KCXD01002761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22698:16352"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..449
     V_segment       92..385
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61243.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       394..400
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..449
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           86 a          141 c          129 g           95 t
ORIGIN      
        1 acatgggaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt tcttcctcct
       61 cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt cgggcccagg
      121 actggtgaag ccttcggaga ccctgtccct cacctgcgct gtttctggtg gctccatcag
      181 cagtgacttc tggagctgga tccgccagcc ccccgggaag ggactggagt ggattggacg
      241 tgtctatggt agcactgata gcaccagcta caacccctcc ctcacgagtc gagtcaccat
      301 ttcaatagac acgtccaaga accagttctc cctgaagctg acctctgtga ccgccgcgga
      361 cacggccgtt tattactgtg cgagagatgc gggaactggg accccctttg actactgggg
      421 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002762             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16588:7779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002762
VERSION     KCXD01002762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16588:7779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61244.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       406..428
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           99 a          142 c          130 g          116 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctatcagc agtactaaat ggtggaactg gatccgccag cccccaggga aagggctcga
      241 gtggattggg tatatcagtg gtagtagtgg taacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa caaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggcct tttattattg tgcgagatcc caatcatatt gtagtgggct
      421 ttactgcttc ggctactact actttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01002763             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:9848:19643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002763
VERSION     KCXD01002763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:9848:19643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61245.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          112 c          150 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg cggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatgc
      241 actgggtccg tcaggctcca ggaaaggggc tggagtgggt ggcagttatc tcgtctgatg
      301 gaagttacaa atactacgaa gactctttga aggaccgatt caccatctcc agagacaatt
      361 ccaggaacat gcaatatctt cagatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01002764             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21203:4538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002764
VERSION     KCXD01002764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21203:4538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61246.1"
                     /translation="CARVDCSGGVCFFDYW"
     D_segment       444..462
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          111 a          113 c          155 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
      241 gcatgaactg ggtccgccag gctccaggga aggggctgga ttgggtgtca attatatcgt
      301 atgatggaac taagaaatac tacgcagact ctgtgaagga ccggttcacc ttctccagag
      361 acaattccaa gaacatactt tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtattactg tgcgagagtg gactgtagtg gtggtgtctg cttttttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002765             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14155:14726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002765
VERSION     KCXD01002765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14155:14726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61247.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          123 c          156 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacattaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtattg acagtggtgg
      301 acatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002766             400 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23541:8146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002766
VERSION     KCXD01002766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 400)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 400)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23541:8146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    32..398
                     /note="immunoglobulin heavy chain variable region"
     V_region        32..398
     V_segment       32..323
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <317..>367
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61248.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       337..343
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       347..398
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        399..>400
                     /gene="IGHG"
BASE COUNT           98 a          105 c          116 g           81 t
ORIGIN      
        1 acatggggca gcagctacag gcgcccactc tgaggtccag ctggtgcagt ctggggctga
       61 ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag gtttccggat acatcttaac
      121 cgaattatcc atgcactggg tgcgacaggc ccctggagaa gggcttgagt ggatgggaag
      181 tgttgatcct caatatggtg aaatgataga cgcagagaaa ttccagggca gagtcaccat
      241 gaccgaggac acgtctacag acacagccta catggaactg agcagtctga gatctgagga
      301 cacggccgta tattactgtg cgacatcatc cagcggcacc tggctatact ggtacttcga
      361 tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002767             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5223:10669
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002767
VERSION     KCXD01002767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5223:10669"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61249.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       398..406
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          136 c          130 g          115 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgttc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccaa atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtaact cctggagctg gatccgccag tccccaggga agggactgga
      241 gtggatcggt tatgtctatg gtgatagtgg gaacaccgaa tacaacccct ccctcaagag
      301 tcgagtcacc atttcaagag actcgtccaa gaatcagttt tccctgaagc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtatcactg tgcgagatac agttacggtt ccaactactt
      421 ctttgggttc tttgactatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002768             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11648:16577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002768
VERSION     KCXD01002768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11648:16577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61250.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          119 a          139 c          132 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt taagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaatttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctactt
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01002769             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17695:19178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002769
VERSION     KCXD01002769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17695:19178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61251.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          140 c          132 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccatc cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagt agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01002770             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13067:12406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002770
VERSION     KCXD01002770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13067:12406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..474
     V_segment       101..394
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61252.1"
                     /translation="CARVVVVSAIKVAGPDLEFW"
     D_segment       401..413
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..474
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>478
                     /gene="IGHG"
BASE COUNT           91 a          135 c          144 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgaag tctctggtgc
      181 ctccatcagt gattactggt ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggga atagtggtta cacttactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgaagctga gctctatgac
      361 cgccgcggac acggccgtgt atttctgtgc gagagttgtg gtggtgtctg ctattaaggt
      421 cgcaggtcct gatttggagt tctggggcca gggcgccctg gtcaccgtct cctccgcc
//
LOCUS       KCXD01002771             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:6090:7630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002771
VERSION     KCXD01002771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:6090:7630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..502
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61253.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>508
                     /gene="IGHG"
BASE COUNT          102 a          126 c          158 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gttcgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcttg
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagtttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtgggagt aacacattct atgcagactc cgtggagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt ctcttcaaat agacggcctg aaacctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatct tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct ccgcagcc
//
LOCUS       KCXD01002772             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13089:12324
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002772
VERSION     KCXD01002772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13089:12324"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61254.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           88 a          133 c          138 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgatg tctcgggggg
      181 ctccatcagt agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtctctacg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgaggtctat
      361 gaccgccgcg gacgcggccg tgtatttctg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002773             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13484:7245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002773
VERSION     KCXD01002773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13484:7245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61255.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          115 c          158 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggtttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga ttgggtggca gttgaatcgt
      301 ttgatggagg taagaaatac tacgctgact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002774             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11051:6717
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002774
VERSION     KCXD01002774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11051:6717"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61256.1"
                     /translation="CATSSSGSWLYWYFDVW"
     D_segment       423..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          142 c          137 g           97 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca gcgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtatatggt gagatgattg
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggtcct gagcagcctg agatctgagg acacggccgt ctattactgt gcgacatcat
      421 ccagcggcag ttggctatac tggtacttcg atgtctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01002775             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10515:15283
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002775
VERSION     KCXD01002775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10515:15283"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61257.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       241..246
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           74 a           68 c           86 g           70 t
ORIGIN      
        1 acatggggca gcctctggat tcagcttcag tggctttggc atgcactggg tccgccaggc
       61 tccagggaag gggctggagt gggtggcagt tatatcgtat gatgaaacta agaaatatta
      121 cgcagactct gtgaaggacc gattcaccgt ctccagagac aattccaaga acatgctata
      181 ttttcaaatg aacaacctga aattggaaga cacggccgtg tattactgtg cgagagatgt
      241 ctatggcagg ggacttgact actggggcct gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002776             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6787:3809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002776
VERSION     KCXD01002776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6787:3809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61258.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          122 a          142 c          135 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga cctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatgtctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01002777             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8449:6910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002777
VERSION     KCXD01002777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8449:6910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61259.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       445..454
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..514
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          119 a          122 c          153 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagctat
      241 ggcatgcact gggtccgcca gtctccaggg gaggggctgg aatgggtggc gcttatatcg
      301 tatgatggaa ctaagaaata ctacgcagac tctatgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgagagt aagcggtata actgaaagtt ccgttgaata cttcgagttc
      481 tggggccagg gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002778             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17599:5047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002778
VERSION     KCXD01002778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17599:5047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61260.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       440..445
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          111 c          153 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaagtgcaac tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt cagcttcagt ggctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaactaa gaaatattac gcagactctg tgaaggaccg attcaccgtc tccagagaca
      361 attccaagaa catgctatat tttcaaatga acaacctgaa attggaagac acggccgtgt
      421 attactgtgc gagagatgtc tatggcaggg gacttgacta ctggggcctg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002779             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8554:9137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002779
VERSION     KCXD01002779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8554:9137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..332
     V_segment       8..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61261.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       260..280
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..332
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           77 a           94 c           95 g           68 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caaggtttcc ggatacacct tcaccgaatt
       61 atccattcac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaggcgttga
      121 tcctgcatat ggtgaattta cacccggaga caagttgcag ggcagagtca ccatgaccga
      181 agacacgtct acagacacag cctacttgga actgagcagc ctgaactctg aggacacggc
      241 cgtctattac tgtgcggccg ggtatagcgg cagctggaac cactggtact tcgatctctg
      301 gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01002780             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:10973:17303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002780
VERSION     KCXD01002780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:10973:17303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61262.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          144 c          132 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aactacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgaattat cattgcactg ggtgcgccag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgacc ctgcatatgg tgaaatgata
      301 cacacagaga tattccaggg cagaatcacc atgaccgagg acacgtcaac agacacagcc
      361 tacatggagc taagcagcct gagatctgag gacacggccg tttattactg tgcgatatca
      421 tccagcggca cctggctatt ctggtacttc gatgtctggg gccctggctc cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01002781             316 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9247:5360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002781
VERSION     KCXD01002781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 316)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 316)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9247:5360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..314
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..314
     V_segment       8..227
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <221..>283
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61263.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       242..254
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       265..314
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        315..>316
                     /gene="IGHG"
BASE COUNT           72 a           77 c           99 g           68 t
ORIGIN      
        1 acatgggtcc ggatacacct tcagtgagat gtccatgcac tgggtgcgac aggcccctgg
       61 aaaagggctt gagtggatgg gatgtgttgc tcctggaaat ggtgaaataa tacacgcaga
      121 gaacttccag gacagagtca ccatgaccga ggacacgtct atagacatag cctacatgga
      181 gctgagtagc ctgagatctg aggacacggc cgtgtattac tgtgcgacag ggaggttcgg
      241 gagcagcgtc tggtccagcc tcttctacgg tttggattcc tggggccaag gggtcgtcgt
      301 caccgtctcc tcagcc
//
LOCUS       KCXD01002782             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20390:10538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002782
VERSION     KCXD01002782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20390:10538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..435
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..435
     V_segment       88..375
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61264.1"
                     /translation="CTGGAYANLDYW"
     D_segment       388..392
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..435
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        436..>441
                     /gene="IGHG"
BASE COUNT           97 a          116 c          134 g           94 t
ORIGIN      
        1 acatggggca ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt
       61 gttgcttttt taagaggtgt ccagtgtgag gtgcagatgg tggagtctgg gggcggcttg
      121 gcaaagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcgc
      181 tactggatga actgggtccg ccaggctcca ggaaaggggc tagaatgggt ctcagctatt
      241 aatactgatg gggagaacac atactacgca gactccgtga agggccgatt ctccatctcc
      301 agagacaact caaagaccac actctccctg caaatgaaca gcctgagacc ggaggacacg
      361 gccgtatatt actgtacggg cggggcgtac gctaacctcg actactgggg ccagggagtc
      421 ctggtcaccg tctccacagc c
//
LOCUS       KCXD01002783             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18065:4756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002783
VERSION     KCXD01002783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18065:4756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61265.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       418..427
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          138 c          144 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga ggtgttgatc ctctatatgg tgaaaaaaga
      301 cacgcagaga agttccaggg cagagtctcc atgaccgagg acacgtctac aaacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtactattg tgcgagagga
      421 tattgtagcg gtagtcactg ctcgtccgga tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002784             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16977:13163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002784
VERSION     KCXD01002784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16977:13163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61266.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       401..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           90 a          134 c          132 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctacaa ttgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct gtctctggtg
      181 gctctatcag tatttactac tggaattgga tccgccaggc cccagggaag ggactggact
      241 ggattggaca tatctatggt agcggtggta gcaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagttctc cctgaacctg aggtctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgagcggtcg gcggcagctg gactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002785             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12917:19598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002785
VERSION     KCXD01002785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12917:19598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61267.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          106 a          125 c          159 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatactac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002786             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16373:7675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002786
VERSION     KCXD01002786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16373:7675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61268.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          113 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg agggggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcatctgatg
      301 gaagtaacaa atactacgca aactctgtga aggaccgatt taccatctcc agagacaatt
      361 ccaagaacat agtatatctt caaatgaaca acctgaaatc ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatg gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002787             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7504:9527
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002787
VERSION     KCXD01002787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7504:9527"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61269.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       437..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          103 a          123 c          156 g          112 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacacacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccattgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct aagactctcc tgtgcagcat ccggattcag cttcagtgac cactgcatgc
      241 actgggtccg ccaggcttca gggaaggggc tggagtgggt ctcaggtatt acttatactg
      301 gtgttaccac atggtacgca gactccgtga ggggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagacc tgaggacacg gctgtctatt
      421 actgtgtggg aggaaggcgg cacgtggacc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002788             366 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:8670:4976
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002788
VERSION     KCXD01002788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 366)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 366)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:8670:4976"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..364
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..364
     V_segment       10..303
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <295..>333
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61270.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       304..309
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       322..364
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        365..>366
                     /gene="IGHG"
BASE COUNT           85 a           85 c          110 g           86 t
ORIGIN      
        1 acatggggtg aggtgcaact ggtggagtct ggagggggct tggttcagcc tggggggtcc
       61 ctgagactct cctgtgcagc ctctggattc accttcagta actttggcat acactgggtc
      121 cgccaggctc cagggaaggg gctggagtgg gtggcagttc tttcatctga tggaagtaag
      181 aaatactacg caaactctgt gaaggaccga ttcaccatct ccagagacaa ttccaagaac
      241 atagtatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtcta ttactgtgcg
      301 agagatgata tggggaccgg ttttgactac tggggccagg gagtcctggt caccgtctcc
      361 tcagcc
//
LOCUS       KCXD01002789             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12381:15718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002789
VERSION     KCXD01002789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12381:15718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61271.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       437..444
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          123 a          142 c          141 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagccaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagttaagaa gcctggggcc tcagtgatgg
      181 tctcctgcca ggtttccgga tacaccgtca ccgaaatatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgctcc tgaaaaaaat gagttaatac
      301 acgcagacaa gttccaggac agagtcagca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtggcctg acatttgagg acacggccgt gtattactgt gcgacccacg
      421 gaggttatag cgacatctgg aactccctat ataacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002790             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22693:15267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002790
VERSION     KCXD01002790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22693:15267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61272.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          121 c          156 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcacaaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt attactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggtg ttaatagtgg
      301 tggggaaagc acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactatatc ttcaaatgga cagcctgaga actgaggaca cggctgtcta
      421 ttactgtgtg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01002791             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19019:4215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002791
VERSION     KCXD01002791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19019:4215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61273.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..451
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          123 c          148 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgct
      121 gctattttaa gaggtgtcca gtgtgaggtc cacctggtgg aatctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttccttt
      241 ggcatgcact gggtccgcca ggcaccgggg aaggggctgg agtgggtggc agttttatcg
      301 tctgatggaa ctaacaaata ctacgcagac tctttgaaag accgattcac catatccaga
      361 gacaactcca agaacatact atatcttcaa ctgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtgtatggc tcggggcttg actactgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01002792             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22578:10210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002792
VERSION     KCXD01002792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22578:10210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..450
     V_segment       84..376
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61274.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       382..398
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..450
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT          105 a          119 c          137 g           91 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccag tctgaggtcc agctggtgca gtctggggct gaggtgaaga
      121 agcctgggac ctcagtgaag gtctcctgca aggtttccgg atacaccttc accgaattat
      181 ccgttcattg ggtgcgacag gcccctggaa aagggcttga gtggatggga agtattgatc
      241 ctctatatgg tgaaatgata cacacagaga agttccaggg cagagtcacc atgaccgagg
      301 acacgtctac agatacagcc tacatggagc tgaggagcct gagatctgac gacacggccg
      361 tgtattactg tgcgaggtcg gatagcggca gttggaacgg ctggtacctc gatctctggg
      421 gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01002793             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17454:3311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002793
VERSION     KCXD01002793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17454:3311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61275.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           95 a          147 c          147 g          109 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtcgcc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01002794             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20966:6259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002794
VERSION     KCXD01002794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20966:6259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61276.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       441..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          111 c          153 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgaagcc tctggattca ccttcagtag ttatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtatgat
      301 gtaagtaaga aatactacgc agacgctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca ccctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtggga gagatgataa tggggtgctt atcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002795             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:26630:7719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002795
VERSION     KCXD01002795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:26630:7719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61277.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       441..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          107 c          155 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gtttcagtaa ttatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggaatggg tggcagttat gtcatctgat
      301 ggaactaaga aattctacgc agactctgtg aaggtccgat tcaccatctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaac agcctgaaat cggaggacac ggccgtatat
      421 tattgtggga gagatgataa tggggtgatt atcgactact ggggccaggg agtcctggtc
      481 accgtcacct cagcc
//
LOCUS       KCXD01002796             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21013:17236
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002796
VERSION     KCXD01002796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21013:17236"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61278.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           84 a          136 c          139 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 tttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tcaccaggga aggggctgga
      241 gtggattggg tttttcggtg gtagtggtgg gaacacctac tacaagtcgt ccctccagag
      301 tcgagtcacc atttcaaccg acacgtccaa gaaccagttc tccctgacac tgacctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat
      421 tgattactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002797             325 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:27749:14421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002797
VERSION     KCXD01002797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 325)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 325)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:27749:14421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..323
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..323
     V_segment       4..253
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <245..>292
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61279.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       256..271
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..323
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        324..>325
                     /gene="IGHG"
BASE COUNT           69 a           89 c           93 g           74 t
ORIGIN      
        1 acatggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
       61 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ccattagtgt
      121 tggtggtagt acatactacg cagactccgt gaggggccga ttcaccatct ccagagacaa
      181 ctcagagagc acgctctccc tgcaaatgaa cagcctgagt actgaggaca cggccgtgta
      241 ttactgtgcc aaaggggata cagctacagt ttattacggt ttggattcct ggggccaagg
      301 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002798             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18571:10163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002798
VERSION     KCXD01002798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18571:10163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61280.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       422..433
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          139 c          141 g          108 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tgatgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctttgcca tcaattgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttgggat aacaaactac
      301 gtgcagaagt tccagggcag agtcaccatt accgcggaca cgtccacaag tatagcctac
      361 atggagctgg gcggcctaag atctgaggac acggccgtgt attactgttc gagagggtca
      421 aattacgagg atgcttccga ttacttttcc gcctttgact cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01002799             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:3929:12954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002799
VERSION     KCXD01002799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:3929:12954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61281.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       428..434
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          112 a          140 c          152 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg cgacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgcaagtga tgaagtaata
      301 cacgcagatg gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 aggttcggta gtagcgtctg gtccaatctc gtctatggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002800             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10255:15546
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002800
VERSION     KCXD01002800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10255:15546"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61282.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       410..416
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           99 a          134 c          130 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtcc agctgcagga
      121 gtcgggccca ggagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcggttact actggaactg gatccgccaa ccaccaggga aggggctgga
      241 gtggattggg tatatcgctg gtagtagtgg gagcatcgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccaattc tccctgaagc tgaactctgt
      361 gaccgccgcg gacacggcca tctattactg tgcgagaaat aggtttatgg gtataagagt
      421 tcttgcctac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002801             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21196:3783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002801
VERSION     KCXD01002801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21196:3783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61283.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       421..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          146 c          139 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctccag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag ctttccggat ccaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaag gggcttgaat ggatgggagg tgttggtcct ctttatggtg aaatgatgca
      301 cgcagacaac ttccagggca gagtcacctt gaccgaggac ccgtctacag acacagccta
      361 catggagctg agcagcctga catctgacga cacggccgtg tattactgtg cgcgtgggcc
      421 tattacaatt tttggcgtac ttattacggg ccttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002802             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11284:10335
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002802
VERSION     KCXD01002802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11284:10335"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..520
     V_segment       142..435
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61284.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       447..460
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..520
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          113 a          143 c          159 g          107 t
ORIGIN      
        1 acatggggtc aacgcagagt acatggggat cacacaacaa ccacatccct cccctacaga
       61 agccccagag cacagcacct caccatggac tggacctgga ggatcctcct cttggtggca
      121 gcagctacag gcgccctctc tgaggtccaa ctggtgcagt ctggggctga ggtgaggaag
      181 cctggggcct cagtgaaggt ctcctgcaag gtttccggag acaccttcac cgatttatcc
      241 atgcactggg tgcgacaggc ccctggaaaa gggcttgagt ggttgggagg tgttgatcct
      301 gcaaatggtg aggtaataca cgcagatagt tttcagggca gagtcaccat gaccgaggac
      361 acgtctacac tcacagccta catggagctg agcggcctga gatctgagga cacggccgtg
      421 tattactgtg cgagagggcg gttcggtagc agcgtctggt ccaatctcgt ctatggtttg
      481 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002803             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21997:12324
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002803
VERSION     KCXD01002803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21997:12324"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..516
     V_segment       141..434
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61285.1"
                     /translation="CTRIWCPRDLTSGCNWFDVW"
     D_segment       458..466
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..516
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          106 a          130 c          157 g          125 t
ORIGIN      
        1 acatggggga gctctgagac aggagcctta gccctggatt ccaagaactt ccactttggg
       61 atcagctctg aacacagagg accatggagt tggggctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagtgt gaggagcacc tcgtggagtc tgggggaggc ctggtccagc
      181 ctggggggtc cctgagactc tcctgtgcag gctctggatt catctttggt gattatggca
      241 tgcactgggt ccgccaggct ccgggaaggg gactggaatg ggtctcgtcc attagtaaca
      301 ctggtaaaac tatatactac actgactccg tgaagggccg attcaccatc tccagagaca
      361 acgcccagaa ctcggtgtct ctgcagatga acagcctgag agccgaggac acggccgtgt
      421 attactgtac tagaatttgg tgtccccgcg atttaaccag cggctgtaat tggttcgatg
      481 tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002804             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:8985:20285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002804
VERSION     KCXD01002804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:8985:20285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61286.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          140 c          134 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatgcactg ggtgcgacag
      241 gcccctggag aagggcttga gtggatggga agtgttgatc ctaaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagtct gagatctgag gacacggccg tatattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01002805             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20302:16727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002805
VERSION     KCXD01002805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20302:16727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61287.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           95 a          146 c          146 g          111 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtccttc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtctcc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01002806             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10351:14362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002806
VERSION     KCXD01002806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10351:14362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61288.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       447..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          111 c          156 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtggcca gtgtgaggtg aagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgc gcagcttccg gattcacctt cagtttctat
      241 ggcatgcact gggtccgcct ggctccaggg aaggggctgg agtgggtggc agttacatcg
      301 aatgatgaaa gtaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatagt atatcttcaa atgaacaacc tgaaattgaa ggacacggcc
      421 gtgtactact gtgggagaga tgataatggg gtgattatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002807             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5982:11171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002807
VERSION     KCXD01002807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5982:11171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..331
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..331
     V_segment       9..270
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <262..>300
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61289.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       277..289
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..331
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        332..>333
                     /gene="IGHG"
BASE COUNT           78 a           76 c          101 g           78 t
ORIGIN      
        1 acatgggggg ttcagccggg ggggtccctg agactctcct gtgcagcctc tggattcacc
       61 ttcagtagca acggcatgca ctgggtccgc caggctccag ggaaggggct ggagtgggtg
      121 gcagtgatat cgtttgatga aagtaagaaa tactatgcag actctgtgaa ggaccgattc
      181 accgtctcca gagacaattc caagaacatg gtatatcttc aaatgaacaa cttgaaattg
      241 gaggacacgg ccgtgtatta ctgtgtgaga gactcttatg gaagtggttt ggattcctgg
      301 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002808             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8582:11134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002808
VERSION     KCXD01002808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8582:11134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61290.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          119 c          150 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt acagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002809             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12855:16518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002809
VERSION     KCXD01002809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12855:16518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61291.1"
                     /translation="CARGLTPDVFGFLGLGYW"
     D_segment       423..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          140 c          141 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct gacatctgag gacacggccg tttattactg tgcgagaggt
      421 ttaacaccag acgtcttcgg tttcctcggg cttggctact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002810             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8407:4209
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002810
VERSION     KCXD01002810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8407:4209"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    23..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        23..318
     V_segment       23..247
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61292.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       254..263
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..318
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           79 a           79 c           93 g           69 t
ORIGIN      
        1 acatggggga gagaggagcc ttagcctctg gattcagctt cagaagttac gaaatgagtt
       61 gggtccgcca ggctccggga aagggactgg agtgggtctc atatattagt cacactggtg
      121 aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga gacaacgcca
      181 agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc gtatattact
      241 gtactagaaa ccggaatact gtaatgattg ggtggttcga tgtctggggc ccgggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002811             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:28285:11399
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002811
VERSION     KCXD01002811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:28285:11399"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..494
     V_segment       128..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61293.1"
                     /translation="CATSSSGTWLYWYFDLW"
     D_segment       433..439
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..494
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          123 a          144 c          134 g           95 t
ORIGIN      
        1 acatggggga gagcatcaca caacaaccac atccctcccc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc
      121 ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaaggtctcc tgcaaggttt ccggatacat cttaaccgaa ttatccatac actgggtgcg
      241 acaggcccct ggaaaagggc ttgagtggat gggaagtgtt gatcctcaat atggtgaaat
      301 gatagacgcc gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac
      361 agcctacatg gaactgagca gtctgagatc cgaggacacg gccgtatatt actgtgcgac
      421 atcatccagc ggcacctggc tatactggta cttcgatctc tggggccctg gctccccaat
      481 caccatctcc tcagcc
//
LOCUS       KCXD01002812             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14813:17880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002812
VERSION     KCXD01002812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14813:17880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..283
     V_segment       8..195
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61294.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       204..226
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       236..283
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           63 a           83 c           71 g           68 t
ORIGIN      
        1 acatggggga tccgccagcc cccagggaaa gggctcgagt ggattgggta tatcagtggt
       61 agtagtggta acacctacta caacccctcc ctcaagagtc gagtcaccat ttcaacagac
      121 acgtccaaca accagttctc cctgaagctg agctctgtga ccgccgcgga cacggccttt
      181 tattattgtg cgagatccca atcatattgt agtgggcttt actgcttcgg ctactactac
      241 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002813             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23855:9798
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002813
VERSION     KCXD01002813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23855:9798"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61295.1"
                     /translation="CARYDEDDYGYYYLDYW"
     D_segment       402..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          140 c          129 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc accagtagct tctggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tctatctatg gtgctactgg gagcaccacc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tatattactg tgcgagatat gacgaggatg attacggtta
      421 ctattacctt gactactggg gccagggagt cctggtcccc gtctcatcag cc
//
LOCUS       KCXD01002814             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19429:12173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002814
VERSION     KCXD01002814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19429:12173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..436
     V_segment       75..365
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61296.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       366..372
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..436
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>440
                     /gene="IGHG"
BASE COUNT           99 a          122 c          123 g           96 t
ORIGIN      
        1 acatggggca cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta
       61 caggcgccca ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg
      121 cctcagtgaa ggtctcctgc aaggtttccg gctacacctt cgccgaattg cccatacact
      181 gggtgcgaca ggcccctgga aaagggcttg agtggatggg aggttttgct tctatatatg
      241 gtgaaataat acatacagag agattccagg gcagagtcac catgacagcg gacacgtcta
      301 tagacacagc ctacatggaa ctcagcagcc tgacatctga ggacacggcc gtgtattact
      361 gtgcggcagc tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc
      421 caatcaccat ctcctccgcc
//
LOCUS       KCXD01002815             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15334:7304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002815
VERSION     KCXD01002815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15334:7304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..495
     V_segment       135..428
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61297.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       435..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          119 c          153 g          120 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggtg aagcctgggg
      181 ggtccctgag actctcctgc gcagcctctg gattcagctt cagttatttc tacatgagct
      241 gggtccgtca ggctccagga aaggggctgg agtggatctc aagtattgac aatggtggga
      301 ctaccacaaa ttttgcagac tccgtgaggg gcaggttcac catctccaga gagaacgcca
      361 agaacacact gtatcttcaa atggacagcc tgagagctga ggacacggct gtctattatt
      421 gtgcgagagc gcgcggggtg atcattacat actttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002816             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12940:19835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002816
VERSION     KCXD01002816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12940:19835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61298.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       432..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           97 a          147 c          132 g          114 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga aaccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggttact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg catatcagtg ggagtagtgg gagcaccgac tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaacag acacgtccaa gagccacttc tccctgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag ctttccccct acgactattt
      421 ttggagtgat ttttactctt actactttga ctacttgggc cagggactcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002817             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:11967:4410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002817
VERSION     KCXD01002817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:11967:4410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..444
     V_segment       90..386
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <378..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61299.1"
                     /translation="CARWEAASFDYW"
     D_segment       392..396
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT           83 a          129 c          133 g          101 t
ORIGIN      
        1 acatgggagt cacggacatc ctgtgtaaga acatgaagca cctgtggttc ttcctcctcc
       61 tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg ggcccagcag
      121 tggtgaagcc tttggagacc ctgtccctca cctgcgctgt ctctggtggc tccgtcagcg
      181 gtggttatgg ctggagctgg atccgccagg ccccagggaa gggactggag tggattggga
      241 gtatctatgg tcatagtggt agcacccgct acaatccctc cctcaagagt cgagtcacca
      301 tttcaaaaga cacgtccaag aaccagttct ccctgaagct gacctctgtg accgccgcgg
      361 acacggccgt gtatttctgt gcgagatggg aagctgcctc ttttgactac tggggtcagg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002818             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23334:14042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002818
VERSION     KCXD01002818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23334:14042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61300.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..432
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          114 a          142 c          139 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac cggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atacaccttc accgaaatat ccatgcactg ggtgcgacag
      241 gcccccggaa aaggacttga gtggatggga agtgttgatc ctgtttatag tgaagaaata
      301 ctcgcagata atttccacga cagagtcacc atgaccgagg acacgtctac aggcacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tatatttctg tgcggcgggc
      421 cttggggggt atctagtgct tactgaatac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01002819             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6208:5395
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002819
VERSION     KCXD01002819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6208:5395"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61301.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       420..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          146 c          139 g           94 t
ORIGIN      
        1 acatgggaga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagca acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccggatt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggcgttga tcctgcatat ggtgaattta
      301 cacccggaga gaagttccag ggcagagtca ccatgaccga ggacacgtct atagacacag
      361 cctacatgga gctgagcagc ctgaactctg aggacacggc cgtctattac tgtgcagccg
      421 ggtatagcgg cagctggaac cactggtact tcgatctctg gggccctggc acccctatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01002820             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14605:8721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002820
VERSION     KCXD01002820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14605:8721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..450
     V_segment       99..391
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <384..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61302.1"
                     /translation="CASLLNPSSDSW"
     D_segment       397..402
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           82 a          134 c          135 g          101 t
ORIGIN      
        1 acatgggggc tctgagagtc acggacctcc tgtgcaagaa catgaagcac ctgtggttct
       61 tcctcctcct ggtggtagct cccagatggg tcctgtccca ggtgcagctg caggagtcgg
      121 gcccaggact ggtgaagtct tcggagaccc tgtccctcac ctgcgctgtt tctggtggct
      181 ccatcagggg ttactggtgg ggctggatcc ggcagtcccc agggaagggt ctggagtgga
      241 ttggctatat cggtggcagt agtgggagca cctactacaa cccctccctc aagagtcgag
      301 tcaccatttc aacagacacg tccaagaacc agatttccct gaagctgacc tctgtgaccg
      361 ccgcggacac ggccgtgtat tcctgtgcga gtcttctaaa cccttcgagt gactcctggg
      421 gccagggagt cctggtcacc gtctcgtcag cc
//
LOCUS       KCXD01002821             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10959:7824
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002821
VERSION     KCXD01002821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10959:7824"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61303.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          138 c          127 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaattgggt ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgagag caccagctac aacccctccc tcacgggtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccagttttcc ctgaggctga gttctatgac
      361 cgccgcggac accgccgtat attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002822             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:10387:18021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002822
VERSION     KCXD01002822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:10387:18021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61304.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          149 c          140 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgagcaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gtcaatggtg aactcataca
      301 cgcagacaag ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggacttg agcagcctga catctgagga cacggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag cc
//
LOCUS       KCXD01002823             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9258:9596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002823
VERSION     KCXD01002823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9258:9596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61305.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          143 c          139 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggttaaga agcctggggc ctcagtgagg
      181 gtctcctgcc aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgatc ctgtaaatgg tgaaataata
      301 cacgcagaca acttccaggg cagagtcacc atgaccgaag acacgtctat agacacagcc
      361 tacatggaac tgagcagcct gagatctgag gatacggccg tatattactg tgcgacccac
      421 ggaggctata gtgacatctg gaactccctg tactacggtt tggattcctg gggccaaggg
      481 gtcttcgtca ccgtctcctc agcc
//
LOCUS       KCXD01002824             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20619:15958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002824
VERSION     KCXD01002824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20619:15958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61306.1"
                     /translation="CVKGETAAAYYGLDSW"
     D_segment       441..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          124 c          152 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 aacctggggg atccctgaga ctctcctgta cagcctctgg attcaccttc aatacttatt
      241 ctatgcattg ggtccgccag gctccaggga aggggctgga gtgggtctca gctgttagta
      301 gtagtgggag cacatactac gcagactccg tgaggggccg atgcaccatc tccagagaca
      361 actcaaagaa cataatctcc ctgcaaatga acagcctgag aactgaggac acggccctat
      421 attactgtgt gaaaggagaa acagctgcag catactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01002825             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18997:13175
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002825
VERSION     KCXD01002825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18997:13175"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..459
     V_segment       84..383
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61307.1"
                     /translation="CARVQGGSYYYGGGYFEFW"
     D_segment       388..404
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..459
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT          100 a          137 c          118 g          106 t
ORIGIN      
        1 acatgggggg actcctgtgc cccaccatgg acacgctttg ctacacactc ctgctactga
       61 ccgtcccgtc ctgggtcttg tcccaggtga ccttgaagga gtctggtcct gcgctggtga
      121 aacccacaca gaccctcacg ctgacctgca ctttctctgg gttctcattc agttcttctg
      181 gaacaggtgt gggctggatc cgtcagcccc cagggaaggc cctggaatgg cttgcaagca
      241 tttattggaa tgatactaaa ttccacagca caacgctgaa gttcaggctc accatctcca
      301 aggacacctc caaaaaccag gtggttctaa caataaccaa cgtggaccct gtggacacag
      361 ccacatatta ctgtgcacgg gtacaaggtg gtagttatta ctacggtggg ggatacttcg
      421 agttctgggg ccagggcgcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002826             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14059:8908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002826
VERSION     KCXD01002826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14059:8908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61308.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          113 c          156 g          119 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agtctctgga ttcaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tgacatcgta
      301 tgatggaagt tggaagtact acggagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagggg aatacagtaa ctctgttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002827             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:10197:9576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002827
VERSION     KCXD01002827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:10197:9576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61309.1"
                     /translation="CTRADRGSSIDFW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          116 c          146 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcttgcactg ggtccgccag ggtccaggga aggggctgga atgggtggcg gttatatctt
      301 atgatgatga taagaaatac tacacagact ctttgaagga ccgattcacc atatccagag
      361 acaattccaa gaacactctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tacgagagcg gatcgcggca gttcaattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002828             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11531:7410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002828
VERSION     KCXD01002828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11531:7410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61310.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       416..427
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          138 c          137 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa gaaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gaatatggtg aaatgatgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggagctgag
      361 cagcctgaga tctgaggaca cggccgtcta ttactgtgcg attggcccta gtggcagctg
      421 gaacgactgg tccttcgaca tttggggacc tggcacccca atcaccgtct cctcagcc
//
LOCUS       KCXD01002829             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20167:14841
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002829
VERSION     KCXD01002829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20167:14841"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61311.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          111 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggttc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcat
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002830             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11754:18293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002830
VERSION     KCXD01002830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11754:18293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..470
     V_segment       89..381
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61312.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       391..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          102 a          129 c          142 g           99 t
ORIGIN      
        1 acatggggcc ctgggaacac agctcatcac catggacttg acctggaggc tcctctttgt
       61 ggtggcagca gctacaggtg cccagtccca ggtccagttg gtgcagtccg gggctgaggt
      121 gaagaggcct ggggcctcag tgaagctctc ctgcaaggct cctggataca tcttcagcat
      181 atctgccatc agttgggtgc gacaggcccc tggacaaggg cttgagtgga tgggagggat
      241 catccctctt gttggtgtaa caacctacgc acagaacttc caggacagag tcacgattac
      301 cgcggacacg tccacaagca cagcctacat ggagctgagc agcctgagat ctgaggacac
      361 ggccgtgtat ttctgtgcga gtggcggctt cgaggatgat aacggtcact attatacgac
      421 actaacattt cacgagtggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002831             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9239:9976
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002831
VERSION     KCXD01002831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9239:9976"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..460
     V_segment       91..382
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61313.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       401..410
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           93 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggag tcacggacat cctgtgcaag aacatgaagc acctgtggct cttcctcctg
       61 ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc gggcccagga
      121 ctggtgaagt cctcagagac cctgtccctc acctgcgctg tctctggtgc ctccatcggt
      181 agttactggt ggacctggat ccgccagccc ccagggaagg gactggagtg gattggggag
      241 atcaatggaa atagcggtag tacctactac agcccctccc tcaagagtcg agtcaccatt
      301 tcaaaagacg cgtccaagaa ccaccactcc ctgaagctga actctgtgac caccgcggac
      361 acggccgtgt atttctgtgc gaacgtctta ggcccctggg gcagctggtc acactacttt
      421 gagtactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002832             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13215:7047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002832
VERSION     KCXD01002832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13215:7047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..328
     V_segment       7..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61314.1"
                     /translation="CARDEGDVSGYRFGYW"
     D_segment       258..263
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           77 a           78 c           99 g           76 t
ORIGIN      
        1 acatgggggg ggtccctgaa actctcctgt gcagcctctg gattcacctt cagtagctat
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      121 tttgatggaa gtaagaaata ctacgcagac tctatgaagg accgattcac catctctaga
      181 gacaattcca agaacatgct atatcttcaa ctgaacaacc tgagattgga ggacacggcc
      241 atgtattact gtgcgaggga tgagggggac gttagcgggt accgatttgg ctactggggc
      301 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002833             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13283:14299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002833
VERSION     KCXD01002833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13283:14299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61315.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          118 c          153 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtg
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cggcctgggg ggtccctgag actctcctgt gcagtctctg gattcacctt cagtaatttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttatatcg
      301 tctgatgaaa gtaagaaata ctatgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaacttgga ggacacggcc
      421 gtctattact gtgcgaggga cgcatttggc agcggctgtg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002834             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16848:7845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002834
VERSION     KCXD01002834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16848:7845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61316.1"
                     /translation="CAFGPTGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          144 c          136 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca ggctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg acacaccttc accgaattgt ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgaag
      301 ttccaggcca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgtg tattactgtg cgtttggccc taccggcagg
      421 tggaacgact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002835             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:18228:19694
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002835
VERSION     KCXD01002835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:18228:19694"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61317.1"
                     /translation="CARVDTSTLDATAADYW"
     D_segment       432..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          118 c          151 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacccag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcat cttcagtacc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcacttata tcgtttgatg
      301 gaagtaagca atattacgca gactctgtga aggaccgatt caccatctct agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag agtggataca tctacacttg atgcaacagc agctgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002836             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27674:17787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002836
VERSION     KCXD01002836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27674:17787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61318.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          130 c          149 g          115 t
ORIGIN      
        1 acatgggtgg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagcctctcc tgtgtagcct ctggattcac cttcagtacc tattccatac
      241 actgggtccg ccagactcca gggaaggggc tggagtgggt ctccgctatt agtactgctg
      301 gtagcacata ctacacagac tccgtgaagg gccgattcac catctccaga gacaactcac
      361 agaacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc ctgtattact
      421 gtgcgaaagg ggagacagct tcagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002837             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12490:10496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002837
VERSION     KCXD01002837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12490:10496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61319.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          122 c          155 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccaatg tgaggtgaaa ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaggttcaa ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tgttaatact
      301 ggtggggaaa gcccatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga atacactata tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tatttctgtg tgagagatcg gcgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002838             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12710:3997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002838
VERSION     KCXD01002838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12710:3997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61320.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          133 c          137 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggctat atatatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtggaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt atttttgtgc gagttcgggt atagaagtgg ttgcgtacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002839             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23292:10332
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002839
VERSION     KCXD01002839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23292:10332"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61321.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          109 c          152 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggtagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac actatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002840             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:23854:8914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002840
VERSION     KCXD01002840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:23854:8914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..336
     V_segment       6..277
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61322.1"
                     /translation="CANALTGGLDYW"
     D_segment       283..291
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       295..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           78 a           89 c          103 g           68 t
ORIGIN      
        1 acatgggggg cggcttggca aaacctgggg ggtccctgag actctcctgt gcagcctctg
       61 gattcacctt cagtagatac tggatgaact gggtccgcca ggctccagag aaggggctgg
      121 agtgggtctc aggtattaat agtggtgggg atagcacaca ctacgcagac tccgtgaagg
      181 gtcgattcac catctccaga gacaactcaa agaacacgct ctccctgcaa atgaacagcc
      241 ttagagcgga ggacacggcc atatattact gtgcgaacgc gttaactggg gggcttgact
      301 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002841             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11110:19495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002841
VERSION     KCXD01002841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11110:19495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61323.1"
                     /translation="CARWSDEDDSGYYYLDFW"
     D_segment       405..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           90 a          142 c          135 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcccccatc agcaatagct tctggcactg gatccgccag cccccaggga aggggctgga
      241 atggattggg tatatctatg gtgctactgg gagcgccagc taccacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccag gaaccagttt tccctgaagc tgagttctgt
      361 gaccggcgcg gacaccgccg tttattactg tgcgagatgg agcgacgagg atgattccgg
      421 ttactattac cttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002842             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23309:11682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002842
VERSION     KCXD01002842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23309:11682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61324.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       411..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          138 c          127 g          111 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagctt ttggatctgg atccgccagc ccccagggaa gggcctggag
      241 tggatagggt ctatctatgg tgctactggg agcacctttt acgacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccaatttt ccctgaagct ggactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatata gcgatactga tagttattac
      421 tactttgact actggggcca gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002843             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11345:6728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002843
VERSION     KCXD01002843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11345:6728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61325.1"
                     /translation="CASGPSGTWNDWHFGIW"
     D_segment       430..442
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          121 a          141 c          140 g           91 t
ORIGIN      
        1 acatggggga catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt cagcgattta tccatacact ggatacgaca
      241 ggcccctgga aaagggcttc agtggatggg aagtgttgat cctgaatatg gtgaaatgat
      301 aaacggagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagtgg
      421 ccctagcggc acctggaacg actggcactt cggtatctgg ggccctggca cgccaatcac
      481 cgtctcctca acc
//
LOCUS       KCXD01002844             352 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13317:20804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002844
VERSION     KCXD01002844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 352)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 352)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13317:20804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..350
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..350
     V_segment       33..275
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>319
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61326.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       283..291
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       305..350
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        351..>352
                     /gene="IGHG"
BASE COUNT           88 a           99 c           90 g           75 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatcccc cccctcagtg agggtctcct gcaaggtttc
       61 cggacacacc tacaccgaag tatccattca ctgggtgcga caggcccctg gaaaagggct
      121 tgagtggatg ggaggtgttg ctcctatata tggtgaaata ctaaacacag acaagttcca
      181 gggcagagtc accatgaccg aggacacgtc tgcagacaca gcctacatgg agttgagcag
      241 cctgagatct gaggacacgg ccgtatatta ctgtgtggcg gctgatagtg gttacccttt
      301 ttactacttc gatatctggg gccctggcac cccaatcagc atctcctcag cc
//
LOCUS       KCXD01002845             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5729:14885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002845
VERSION     KCXD01002845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5729:14885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61327.1"
                     /translation="CTRGIDNYHFSNTDFDFW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          119 c          146 g          133 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga atctggggga ggcttggtac
      181 aacctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtagctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtttcc ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 acgccaagaa ctccttgtat cttctaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtac aagggggata gataactacc actttagtaa tacggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002846             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18712:14632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002846
VERSION     KCXD01002846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18712:14632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61328.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          119 c          153 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctgggggag gcttggttcg
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca atagttttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtgtcag ttatatcgtc
      301 tgatgaaagt aagaaatatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaagt gaacaacctg aagctggagg acacggccct
      421 ctattactgt gcgagagacg catatggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002847             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12484:11312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002847
VERSION     KCXD01002847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12484:11312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61329.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           81 a          141 c          136 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt cgccagggaa ggggctggag
      241 tggattgggt ttttcggtgg ttatggtggg aacacctact acaacccctc cctccaaagt
      301 cgagtcacca tttcaaccga cacgtccaag acccagttct ccctgattct gacctctgtg
      361 accgccgcgg acacggccct ctatttctgt gcgaggggga acatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002848             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16982:20845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002848
VERSION     KCXD01002848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16982:20845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..494
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61330.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          112 a          119 c          153 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatgaaac taggaaatac tacgcagact ctgttaggga ccgattcacc gtctccagag
      361 acaattccaa caacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tacgagagac gcatttggca gcggctgtga ctactggggc ctgggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01002849             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18625:12238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002849
VERSION     KCXD01002849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18625:12238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61331.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          116 c          150 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 cttccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tttctagaga
      361 caattccatg aacatgctat ttcttcaaat gaacaacctg aacttggacg acacggccgt
      421 ctattactgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002850             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9310:4289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002850
VERSION     KCXD01002850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9310:4289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61332.1"
                     /translation="CARRPLPYEDDYSYYLGIFDYW"
     D_segment       410..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           99 a          134 c          139 g          115 t
ORIGIN      
        1 acatgggggt tctcttagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtgattatg gctggaactg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtatttatg gtagtagtgg taacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagaaga ccgcttccct acgaggatga
      421 ttacagttat tatttgggga tctttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01002851             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13195:11972
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002851
VERSION     KCXD01002851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13195:11972"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61333.1"
                     /translation="CANALTGGLDYW"
     D_segment       436..444
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          104 a          121 c          158 g          108 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg tactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcagctatt gcaagtggtg
      301 gagaaagcac atactatgca gactccgtga agggccgatt caccgtctcc agagacaact
      361 caaagaacac agtctccctg caaatgaaca gtcttagcgc ggaggacacg gccgtgtatt
      421 actgtgcgaa tgcgttaact gggggtcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01002852             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19725:15292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002852
VERSION     KCXD01002852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19725:15292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61334.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          113 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatatctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002853             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13086:3294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002853
VERSION     KCXD01002853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13086:3294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61335.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       408..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           92 a          144 c          126 g          109 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacgtgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca aagattacca ctggagctgg atccgccagc cccctgggaa gggactggag
      241 tggattggac atatctctca tagtcgtgga agcaccgact acaacccctc cctcaagagt
      301 cgcgtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gagctctgtg
      361 acccccgcgg acacggccgt ctattactgt gcgagagatc aggattctta cgtttactat
      421 cgcttctttg acttctgggg ccagggagtc ctggtcgccg tctcctcagc c
//
LOCUS       KCXD01002854             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23809:13946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002854
VERSION     KCXD01002854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23809:13946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..359
     V_segment       7..298
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <290..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61336.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       307..311
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       318..359
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           81 a           89 c          108 g           83 t
ORIGIN      
        1 acatggggtc cacctggtgg aatctggagg aggcttggtt cagccggggg ggtccctgag
       61 actctcctgt gcagcctctg gattcacctt cagtaccttt ggcatgcact gggtccgcca
      121 ggctccaggg aaggggctgg agtgggtggc agttatatcg tctgatggaa gtaagaaata
      181 ctacgcagac tctttgaaag accgattcac catatccaga gacaactcca agaacatagt
      241 atatcttcaa ctgaacagcc tgaaattgga ggacacggcc gtgtattact gtgcgagaga
      301 tgtgtatggc tcggggcttg actactgggg ccagggagtc ctgctcaccg tctcctcagc
      361 c
//
LOCUS       KCXD01002855             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22328:17060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002855
VERSION     KCXD01002855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22328:17060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..490
     V_segment       106..402
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <394..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61337.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       412..433
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT           99 a          142 c          135 g          116 t
ORIGIN      
        1 acatggggga aatgttctct gagagtcacg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacatg cgctgtctct
      181 ggtggctcta tcagcagtac taaatggtgg agctggatcc gccagccccc agggaaaggg
      241 ctggagtgga ttgggtatat cagtggtagt agtggtaaca cctactacaa cccctccctc
      301 aagagtcgag tcaccatttc aacggacacg tccaacaacc agttctccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtttat tattgtgcga gatcccaatc ctattgtagt
      421 gggctttact gcttcggcta ctactacttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002856             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17645:10391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002856
VERSION     KCXD01002856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17645:10391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..485
     V_segment       125..418
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61338.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       428..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          100 a          145 c          133 g          109 t
ORIGIN      
        1 acatgggggg agtccccctc accgcacagc tgggatctca gtgcttcctt ttctgtcctc
       61 caccacgatg gggtcaactg ccatcctcac cctcctactg gctgttctcc aaggagtctg
      121 tgccgaggtg cagctggtgc agtctggagc agaggtgaaa aggcccgggg agtctctgaa
      181 gatctcctgt aagacttctg gatacagctt taccagttac tggatcacct gggtgcgcca
      241 gatgcccggg aaaggcctgg agtggatggg ggcgattgat cctagtgatt ctgctaccaa
      301 atacagcccg tccttccaag gccaggtcac catttcagcc gacaagtcca tcaccaccgc
      361 ctacctagaa tggagcagcc tgaaggcctc ggacaccgcc acgtattttt gtgcgaaagg
      421 tcccggagtg attattaact actttgacta ctggggccag ggagccctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01002857             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6826:6443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002857
VERSION     KCXD01002857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6826:6443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61339.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          113 c          153 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcacgatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tcgggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca ctacctatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaaca aagaaatact acgcagactc tctgaaggac cgcttcatca tctccagaga
      361 caattccaag aatatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgagagatg ttaggggaac ggggtttgac ttctggggcc agggtgtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002858             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12795:5698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002858
VERSION     KCXD01002858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12795:5698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61340.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       420..426
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          139 c          147 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat actgtatctg gtggagagat
      301 atacgcagag aacttccagg gcagagtcac catgaccgag gacacggcca aagacacagc
      361 ctacatggag ctgaccagcc tgagatctga ggacacggcc gtttattact gtgcgagagg
      421 tgtgacggca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002859             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21495:11019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002859
VERSION     KCXD01002859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21495:11019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..509
     V_segment       134..427
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61341.1"
                     /translation="CARERFGGIGVIIYSWVDFW"
     D_segment       445..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..509
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          107 a          124 c          161 g          119 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtatt tctgttcggc gatcagcact
       61 aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttcttg ctcttttgaa
      121 aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa agccgggggg
      181 gtccctgaga ctctcctgcg cagcctccgg attcaccttc agtgacttct acatggactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtctca cgtattaatc atgacggtgg
      301 taacacatgg tacgcagact ccgtgagggg cagattcacc atctccagag agaacgccaa
      361 gaacacactg tatcttcaaa tagacaggct gagacctgag gacacagccg tgtatttctg
      421 tgcgagagag cggtttgggg gaattggggt gattatctac agctgggtcg atttctgggg
      481 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002860             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11159:14371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002860
VERSION     KCXD01002860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11159:14371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61342.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          114 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc catttggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtcg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaaactttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggct gttatctcgt
      301 atgatgaaaa taccaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tgtattattg tgtgcgagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002861             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19209:13230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002861
VERSION     KCXD01002861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19209:13230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61343.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       430..436
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          112 a          118 c          144 g          116 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaggtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcatgttc aatacctatg ccatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc atgatggaac
      301 taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag acaattccaa
      361 gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca tatactactg
      421 tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01002862             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21229:8804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002862
VERSION     KCXD01002862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21229:8804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61344.1"
                     /translation="CARPRSIGVRYLGYW"
     D_segment       418..423
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           93 a          138 c          136 g           97 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg gctggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cggttactac tggaactgga tccgccaacc tccagggaag gggctggagt
      241 ggattggata tatcggtggg agtagtggga tcacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgagactg acctctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgagaccaag gagcataggg gtgcgatacc
      421 tgggctactg gtgccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002863             355 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7151:14250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002863
VERSION     KCXD01002863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 355)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 355)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7151:14250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..353
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..353
     V_segment       8..279
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>322
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61345.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       292..300
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..353
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        354..>355
                     /gene="IGHG"
BASE COUNT           82 a           76 c          116 g           81 t
ORIGIN      
        1 acatgggggg gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggtttc
       61 cggatacagt gtcaccgaat tatcgattca ctgggtgcga caggccccgg gaaaagggct
      121 tgagtggatg ggaggtgttg atcctgtaaa aggtgaagaa attcacggag aggagttcca
      181 ggacagagtc accatgaccg aggacccgtc tacagacaca gcctacatgg agttgagcaa
      241 cctgagatct gaggacacgg ccgtgtatta ttgtgcgagt gggtttagta tctggttatt
      301 ttacgacgtt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01002864             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14521:18818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002864
VERSION     KCXD01002864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14521:18818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61346.1"
                     /translation="CARDLNTALSYNSLDVW"
     D_segment       400..406
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..466
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          144 c          123 g          108 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagca ataactactg gacctggatc cgccaatccc cagggaaggg actggagtgg
      241 attggacgta tctctggtta tggtgacttc accgcctaca acccctccct cgagagtcga
      301 gtctccattt caaaagactc gtccaagagc caattctccc tgaaactgaa ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagatctca atacagccct ttcgtacaac
      421 tcattggatg tctggggccg gggacttctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002865             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10878:5700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002865
VERSION     KCXD01002865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10878:5700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61347.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       419..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          143 c          138 g          100 t
ORIGIN      
        1 acatggggga tcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagctg caggtctcca
      121 gtcccaggtc cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgac
      181 ggtttcctgc ggggcctctg gattcacctt cgacacccat ggaatcaact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg agtgatcatc ccccttattg gtatcacaaa
      301 ctacgcaaag aactctcagg gcagagtcac aataaccgcg aacacgtcca caaacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc atctattatt gtgcgagaga
      421 atactgtact tctagtagtt gcgccgggtt ccttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002866             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15481:9526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002866
VERSION     KCXD01002866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15481:9526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..486
     V_segment       121..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61348.1"
                     /translation="CAGGPSGIWNGWYFDIW"
     D_segment       420..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>489
                     /gene="IGHG"
BASE COUNT          115 a          142 c          136 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gacttatcca ttcactgggt gcgactggcc
      241 cctggaaaag ggcttcagtg gatcggaagt gttgatcctg catatggtga aatgataaac
      301 gcagagaatt tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagttaa gcagcctgag atctgaggac acggccgtgt attactgtgc gggtggccct
      421 agcggcatct ggaacggctg gtacttcgat atctggggcc ctggcacccc aatcaccgtc
      481 tcctcaacc
//
LOCUS       KCXD01002867             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19805:17156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002867
VERSION     KCXD01002867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19805:17156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61349.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           81 a          136 c          145 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg gacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaag aaccagttct ccctgaggct gagttctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc ggcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002868             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:21554:16680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002868
VERSION     KCXD01002868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:21554:16680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..495
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61350.1"
                     /translation="CARVVYYDSSYSTSPYNRFDVW"
     D_segment       424..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..495
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          139 c          142 g          107 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg gtacaccttc agcatctatg ccatcagttg ggtgcgacag gcccctgggc
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg tataacaaat tacgcacaga
      301 ggttccaggg cagagtcacc attaccgcgg acacgtccac aagcacagcc tacatagacc
      361 tgagtagcct gagatctgag gacacggccg tgtattactg tgcgagagtt gtatactatg
      421 atagtagtta ttccacgagt ccctacaacc ggttcgatgt ctggggcccg ggagtcctag
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002869             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4859:14647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002869
VERSION     KCXD01002869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4859:14647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61351.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       260..272
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           79 a           78 c           86 g           76 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaaactatgg
       61 catgcactgg gtccgccagg ccccagggaa ggggctggat tgggtggcag ttatgtcgtt
      121 tgatgaaaat gtgaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      181 caattccaag aatatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      241 gtattactgt gcgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002870             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6918:12387
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002870
VERSION     KCXD01002870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6918:12387"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61352.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       402..416
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           95 a          136 c          133 g          106 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggcg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg atatattagt attagtggga ggaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaagttg acctctgtga
      361 ccgtcgcgga cacggccgtg tattactgtg cgagatatcc atatagtggg agctacttca
      421 ggtactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002871             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19630:8630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002871
VERSION     KCXD01002871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19630:8630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61353.1"
                     /translation="CARAVGGAAGYFDFW"
     D_segment       437..444
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          126 c          153 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccattg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgaactggg tccgccagac tccaggcaag gggctggaat ggatctcagg tattaacact
      301 ggtggcatta acacatacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 gacgccaaga acacactgtt tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagcagt gggtggtgcc gcaggatact tcgatttctg gggcctgggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002872             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17347:9941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002872
VERSION     KCXD01002872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17347:9941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61354.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          114 c          155 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcattcact gggtccgcca gactccgggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagacata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt gtattttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgtgcgaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002873             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14825:16665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002873
VERSION     KCXD01002873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14825:16665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61355.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       412..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          113 a          134 c          133 g          106 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacttg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggcgca gtctggggct gacgtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccttc accgaattat ccctgcactg ggtgcgacag
      241 ggccctggaa aaggacttga gtggatggga ggttttgctt ctatatatgg tgaattaatc
      301 catgaaaggt tccagggaag agtcagtttg accgaggaca cgtccacaga cacagcctat
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc ggcagctgat
      421 agtggttacc cattttacta cttcgatatc tggggccctg gcaccccaat caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01002874             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:22741:8583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002874
VERSION     KCXD01002874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:22741:8583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61356.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          112 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gatacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002875             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:19615:10881
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002875
VERSION     KCXD01002875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:19615:10881"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61357.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       441..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          152 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttaaa tcgtttgatg
      301 gaaccaagat atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcctac gggagcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002876             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16583:14555
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002876
VERSION     KCXD01002876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16583:14555"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..519
     V_segment       144..443
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <435..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61358.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       446..452
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..519
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          116 a          126 c          158 g          121 t
ORIGIN      
        1 acatggggct ctgggagagg agacccagcc ttgggattcc caggcgtctc cacttggtga
       61 tcagcactga acacaagaga ctcaccatgg agtttgcact gagctgggtt ttcgttgttg
      121 ctactttaaa aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtcc
      181 agcctggcgg gtccctgaga ctctcctgtg caggctctgg attcaccttc agtgactatg
      241 ccatgagctg ggtccgccag gcttctggga aaggactgga gtgggttggc tatattagaa
      301 gcaaatctta caattacgcg acagaatacg ccgcatcggt gaaaggcagg ttcaccatct
      361 ccagagatga ttcaaagtac acgctacatc tgcaaatgag cagcctgaaa accgaggaca
      421 cggccgtgta ttactgtgct agaggggata taccggctat agaggcctac tacggtttgg
      481 attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01002877             545 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21491:11382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002877
VERSION     KCXD01002877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 545)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 545)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21491:11382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    171..543
                     /note="immunoglobulin heavy chain variable region"
     V_region        171..543
     V_segment       171..461
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <456..>512
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61359.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       470..484
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       502..543
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        544..>545
                     /gene="IGHG"
BASE COUNT          122 a          153 c          156 g          114 t
ORIGIN      
        1 acatgggggc actggtgtct gccgaggtaa atacagatct gtccttgtcc agagagcatc
       61 acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc accatggact
      121 ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct gaggtccagc
      181 tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc tcctgcaagg
      241 tttccggatc caccttcacc gaattatcca tacacggggt gcgacaggcc cctggaaaag
      301 ggcttgagtg gatgggaggt gttgctcctc tatatggtga aatgatgcac gcagacaact
      361 tccagggcag agtcaccttg accgaggaca cgtctacaga cacagcctac atggagctga
      421 gcagcctgag atctgacgac acggccgtgt attactgtgc gcgtgggcct attacaattt
      481 ttggcgtact tattacgggg cttgactatt ggggccaggg agtcctggtc accgtctcct
      541 cagcc
//
LOCUS       KCXD01002878             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10979:8350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002878
VERSION     KCXD01002878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10979:8350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61360.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          111 a          116 c          154 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagtctctgg attcaccttc aggaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ttgatggaat taagagttat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa gaacatgcta aatcttcaaa tgaacgacct gaaattggag gacacggccg
      421 tgtattactg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01002879             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12164:17759
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002879
VERSION     KCXD01002879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12164:17759"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61361.1"
                     /translation="CATADYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          111 a          121 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag tatgaaatac tacgcagact ctatgaagga ccgcttcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaagaccct gaaattggag gacactgccg
      421 tttattactg tgcgacagcc gactacggta acagccttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01002880             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5427:19416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002880
VERSION     KCXD01002880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5427:19416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61362.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          112 c          148 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtcggg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtctt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatacgaa atactacgca gactctgtga agggccgatt caccatctcc agagacaatt
      361 ccaagaacat gttatatctt caaatgaata acctgcaatt ggaggacacg gccctgtatt
      421 actgtgcgag aggagaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002881             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9646:22503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002881
VERSION     KCXD01002881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9646:22503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61363.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       444..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          113 c          155 g          125 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtcctgtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctcgggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atgtcgtctg
      301 atggaagtag catatactac gcagcctctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgttatat cttcaaatga acaacctgaa gtttgaggac acggccgtgt
      421 attactgtgc gagagatgtg tacggtagtg ggttagacta ctggggcctg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002882             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:3220:9252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002882
VERSION     KCXD01002882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:3220:9252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61364.1"
                     /translation="CARWGTPFDYW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           91 a          133 c          131 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtag
      181 ctccatcaac agtggttatg cctggagctg gatccgccag cccccagaga aggggctgga
      241 gtggattggg catatctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgagatctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagatgg gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002883             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24852:10897
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002883
VERSION     KCXD01002883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24852:10897"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61365.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          112 a          116 c          159 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctccgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa gggactggag tgggtggcac tgatttcgta
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcaccc tctccagaga
      361 caattccgag aacatcctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttttgt gcgagagttg gagagggtac tggtggtgcg gaggactttg acttctgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002884             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:22697:10291
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002884
VERSION     KCXD01002884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:22697:10291"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..321
     V_segment       8..256
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <249..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61366.1"
                     /translation="CSRGNIAATGIDYW"
     D_segment       263..272
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           63 a           94 c           95 g           71 t
ORIGIN      
        1 acatgggggg gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc agcggttact
       61 ggtggggctg gatccgccag cccccagaga aggggctgga gtggattggg tatatcggtg
      121 gtagtaatgg gaacaccttc tacaacccct ccctcaagag tcgagtcacc atttcaacag
      181 acacgtccaa gaaccagttc tccctgaatc tgatctctgt gtccgccgcg gacacggccg
      241 tgtattactg ttcgaggggg aatatagcag cgactggcat tgactactgg ggccagggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002885             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19323:12027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002885
VERSION     KCXD01002885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19323:12027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61367.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       451..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          118 a          114 c          151 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctgttttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatgcaa gtaagacata ctacgcaaac tctgtgaagg accgattcac catattaaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga cgatatggga agtggctttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002886             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10669:11441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002886
VERSION     KCXD01002886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10669:11441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61368.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       426..431
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          109 c          144 g          116 t
ORIGIN      
        1 acatgggggc ctggaagtcc acagtgttcc attcggtgat cagcacagaa cacagaggac
       61 tcaccatgaa gtttgggctg agctgggttt tccttgttgc tattttaaga ggtgtccagt
      121 gtgaggtaca gctggtggag tctggaggag acttggttca ccctgggggg tccctgagac
      181 tctcctgtgc agcctctgga ttcaccttca gtaactttgg catacactgg gtccgccagg
      241 gtccagggaa ggggctggag tgggtggcag ttatatcgta tgatgaaact aggacatact
      301 acgcagactc tgtgaaggac cgattcacca tctccagaga caattccaag aacatgatat
      361 ttcttcaaat gaacaacctg aaattggagg acacggccgt gtattactgt gcgagagatg
      421 tcaggggaac ggggtttgac tactggggcc agggagtcct ggtccccgtc tcctcagcc
//
LOCUS       KCXD01002887             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21930:17794
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002887
VERSION     KCXD01002887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21930:17794"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..489
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61369.1"
                     /translation="CANGVAGLDFW"
     D_segment       434..440
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          103 a          122 c          156 g          110 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatatg
      241 caatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattagca
      301 gtggtggtaa cacatactac gcagactccg tgaagggccg attcaccatc tccagagacg
      361 actcaaagag cacactctcc ctgcaaatga acagcctgag acctgaggac acggcctttt
      421 attactgtgc gaatggggtg gcaggtttag acttctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01002888             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8052:20301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002888
VERSION     KCXD01002888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8052:20301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..345
     V_segment       9..270
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61370.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       279..290
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..345
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           85 a           91 c           95 g           76 t
ORIGIN      
        1 acatgggggt gaagaagcct ggggcctcag tgaaggtctc ctgcaaagtt tccggataca
       61 tcttcaccga attatcgttc cactgggtgc gccaggcccc tggaaaaggg cttgagtggg
      121 tgggaagtgt tgatcctgca tttggtgaaa tgatacacac agagaaattc cagggcagaa
      181 tcaccatgac cgaggacacg tccacagaca cagcctacat ggaactaagc agcctgagat
      241 ctgaggacac ggccgtgtat ttctgtgcga tatcatccag cggcagctgg ctattctggt
      301 atttcgacat ctggggccct ggcactccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01002889             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16881:10598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002889
VERSION     KCXD01002889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16881:10598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..325
     V_segment       7..255
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <247..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61371.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       258..273
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..325
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           69 a           89 c           95 g           74 t
ORIGIN      
        1 acatgggggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
       61 gctatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtctc agccattagt
      121 gttggtggta gtacatacta cgcagactcc gtgaggggcc gattcaccat ctccagagac
      181 aactcagaga gcacgctctc cctgcaaatg aacagcctga gtactgagga cacggccgtg
      241 tattactgtg ccaaagggga tacagctaca gtttattacg gtttggattc ctggggccaa
      301 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002890             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23234:11648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002890
VERSION     KCXD01002890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23234:11648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61372.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       360..369
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       370..410
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           88 a           97 c          127 g          100 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctattttt agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt ccagcctggg ggctccctga gactctcctg
      121 tgcagcctct ggattcacct tcaataccta tggcatgcac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cagttatatc acatgatgaa actaagagat actacgcaga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatgc tatatcttca
      301 aatgagcaac ctgaaattgg aggacacggc cgtgtattac tgtgtgagag acgcatttgg
      361 cagcggctgt gactactggg gccggggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002891             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10051:11459
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002891
VERSION     KCXD01002891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10051:11459"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..501
     V_segment       143..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61373.1"
                     /translation="CARARGVIITYFDYW"
     D_segment       443..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>505
                     /gene="IGHG"
BASE COUNT          103 a          124 c          160 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgacctgg gtccgccagg ctccagggaa ggggctggaa tggatctcag gtattagcag
      301 tggtggggat agcacatcct atgcagactc cgtgaagggc agattcacca tctcccgaga
      361 ggacgccaag aacacactgt atcttcagat ggacagtctg agagttgagg acacggctgt
      421 ctattactgt gcgagggcgc gcggggtgat tattacatac tttgactact ggggccaggg
      481 agtcctggcc accgtctcct cggcc
//
LOCUS       KCXD01002892             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22910:8762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002892
VERSION     KCXD01002892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22910:8762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61374.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       436..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          112 c          154 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt atatctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtcagtt atatcgtctg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attcaaaaaa catggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgt gagagatgcc ttcgggggcg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002893             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15118:18810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002893
VERSION     KCXD01002893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15118:18810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61375.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          111 a          144 c          139 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat ccaccttcac cgagttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcatatggtg aaatgataaa
      301 cgcagagaag ttccagggca gagtcaccct gaccgaggac acgtctacat acacagccta
      361 catggagctg agcagcctgt catctgagga cacggccgtg tatttctgtg cgagtggccc
      421 tagcggcagc tggaacggct ggtacttcga tttctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01002894             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18937:16381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002894
VERSION     KCXD01002894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18937:16381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..499
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61376.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       442..448
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          118 c          149 g          117 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgca
      121 attttaagag gtgtccagtg tgaggtacag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttatggc
      241 atacactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgttt
      301 gatggagaaa agaaaatcta cgcagactct gtgaaggacc gaatcaccat ttccagagac
      361 gattccaaga acacgctata tcttcaaata aacaacctga aattggagga cacggccgtg
      421 tattactgtg cgagacgccc ttggaacgct gactactttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002895             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12101:19398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002895
VERSION     KCXD01002895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12101:19398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..518
     V_segment       143..435
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <434..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61377.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       449..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          119 a          125 c          151 g          125 t
ORIGIN      
        1 acatggggtc tgggagagga gacccagcct tgggatttcc agctgtctcc agttggcgat
       61 cagcactgaa cacaggagac tcgccatgga gtttgtactg agctgggttt tccttgttgc
      121 tatattaaaa ggtgtccggt gtgaggtgca gctggtggag tctgggggag gcttggtcca
      181 gcctggcggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactttgc
      241 catgagctgg gtccgccagg cttctgggaa aggactggag tgggttggct atattagaac
      301 caaatataac aattacgcgg cagaatacgc cgcatcggtg aaaggcaggt tcaccatctc
      361 cagagatgat tcaaagaaca cgatatatct gcaaatgagt agcctgaaaa ccgaggacac
      421 ggccgtgtat tactgcacca catggagata ttactatagt actggttacc ccacctttga
      481 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002896             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11675:6131
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002896
VERSION     KCXD01002896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11675:6131"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..523
     V_segment       145..443
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61378.1"
                     /translation="CASLGGIVVFPARLRFDVW"
     D_segment       455..461
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       479..523
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          110 a          120 c          164 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga agagaccccg cctgggattc ccaggagttt ccacttggtg
       61 atcagcactg aacacaaacc accagccatg gagtttgggc tgagctgggt tttccttgtt
      121 gctatttgga aaggtgtcca gtgtgaggtg cagttggtgg agtccggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gtagcctctg gattcagctt cagtgattat
      241 gctatggact gggtccgcca ggctccagga aaggggctgg agtgggtagg tttcattaga
      301 agtagatctt atggtgggac agcagaatac tccgcgtctg tgaaaggcag attcaccatc
      361 tccagagatg attcaaagaa tacgacgtat ctgcaaatga ctagcctaaa aaccgaggac
      421 acggccgtgt attactgtgc tagtctaggg gggatagtag tttttcctgc tcgccttagg
      481 ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002897             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22924:15962
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002897
VERSION     KCXD01002897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22924:15962"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61379.1"
                     /translation="CARWEAADFDYW"
     D_segment       408..414
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           89 a          130 c          139 g          103 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg ccatcctgtg taagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc agcagtggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgggtccat cagcggtggt tatggctgga gttggatccg ccaggcccca gggaagggac
      241 tggagtggat tgggactatg tatggtcata gtggcagcac ccactacaat ccctccctca
      301 agagtcgagt caccatttca aaagacatgt ccaagaacca gttttccctg acgttgagct
      361 ctctgaccgc cgcggacacg gccgtgtatt actgtgcgag atgggaggca gcggactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002898             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16227:17984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002898
VERSION     KCXD01002898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16227:17984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..429
     V_segment       63..354
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61380.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       368..374
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       378..429
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT          100 a          113 c          129 g           89 t
ORIGIN      
        1 acatggggga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
       61 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      121 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      181 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      241 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      301 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      361 ccagcggcac ctggctatac tggtgcttcg atatctgggg ccctggcacc ccgatcacca
      421 tctcctcagc c
//
LOCUS       KCXD01002899             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21563:14862
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002899
VERSION     KCXD01002899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21563:14862"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61381.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          121 a          138 c          135 g           93 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaagtc caaggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcgtccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 gtcagcc
//
LOCUS       KCXD01002900             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20187:8878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002900
VERSION     KCXD01002900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20187:8878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61382.1"
                     /translation="CVRYEDESIDYHFDYW"
     D_segment       414..422
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcttggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcatca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttccgtg
      361 accgccgcgg acaccgccat gtattactgt gtgagatatg aggatgaatc cattgactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002901             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12120:20668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002901
VERSION     KCXD01002901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12120:20668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..493
     V_segment       115..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61383.1"
                     /translation="CASGGYEDDSGYYFPDFFDSW"
     D_segment       414..434
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          107 a          134 c          145 g          109 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggctgctg gatacatttt cagcatctct gccatcagtt gggtgcgaca ggcccctgga
      241 cagggacttg agtggatggg agggatcatc cctcttgttg gtataacaaa ctacgcacag
      301 aacttccagg gcagagtcac gattaccgcg gacaggtcca caagcacagc ctacatggat
      361 ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagcgg tggttacgag
      421 gatgattccg gttattattt tccagacttc tttgactcct ggggccaggg agtcctggtc
      481 aaagtctcct cagcc
//
LOCUS       KCXD01002902             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:5672:12576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002902
VERSION     KCXD01002902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:5672:12576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61384.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          112 a          120 c          154 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cacaaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcaattat tactacatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaagtatt aatagtggtg
      301 gggaaagcac atactctgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actatatctt caaatggaca gcctgagaac tgaggacacg gctgtctatt
      421 actgtgtgag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002903             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12699:16577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002903
VERSION     KCXD01002903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12699:16577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61385.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          116 c          151 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtttctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtctgtaatt tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacat actatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002904             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10128:15325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002904
VERSION     KCXD01002904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10128:15325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61386.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          141 c          136 g          100 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccttacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaac ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcaat tggctttttt ggtacttcga tttttggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01002905             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20313:5137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002905
VERSION     KCXD01002905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20313:5137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..488
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61387.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>494
                     /gene="IGHG"
BASE COUNT          109 a          115 c          156 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagc agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgaa tcgcacgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatacctt caaatgaaca acctgaaatt ggtggatacg gccatgtact
      421 attgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcccc agcc
//
LOCUS       KCXD01002906             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14860:9511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002906
VERSION     KCXD01002906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14860:9511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61388.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       445..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          117 c          148 g          117 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag aagtccaatg tgaggtgcac ctggtggaat ctggaggagg ttcggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tacctttggc
      241 attcactggg tccgccaggc tccggggaag gggctggagt gggtggcagt tatatcgtat
      301 gatgaaacta agacatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaca acatggtata tcttcaaatg aacaacctga aattagagga cacggccgtg
      421 tattactgtg cgagagatgt caggggaacg gggtttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01002907             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19488:16996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002907
VERSION     KCXD01002907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19488:16996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61389.1"
                     /translation="CARGVDNHHYSETEFDFW"
     D_segment       453..459
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          121 c          153 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga gtctggggga ggcttggtac
      181 agccgggggc gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtggatatca ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg gttcaccatc tccagagaca
      361 atgccaagaa ctccttgtat cttcaaatga acagcctgag agctgaggac actgctgtgt
      421 attattgtgc aagaggcgta gataaccacc actacagtga gacggagttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002908             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24374:15222
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002908
VERSION     KCXD01002908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24374:15222"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61390.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       425..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          114 a          141 c          140 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagagg cctggggcct cagttaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaaatatcc atgcactggg tgcgacaggc
      241 ccccggaaaa ggacttgagt ggatgggaag tgttgatcct gtgtatagtg aagaaatact
      301 cgcagataat ttccacgaca gagtcaccat gaccgaggac acgtctacag gcacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgta tatttctgtg cggcgggcct
      421 tggggggtat ctagtgctta ctgaatacct cgaattctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01002909             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17250:16082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002909
VERSION     KCXD01002909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17250:16082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..413
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61391.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       425..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          120 a          140 c          138 g          102 t
ORIGIN      
        1 acatgggact caacaactgc atccaacctc aagagaagcc cctgagagca cagtttctca
       61 ccatggactt gacctggaag atcctcctct tggtgacagc agccacaggt gcccactccc
      121 aggtgcaact ggtgcagtct gggggtgaga ttaagcagcc tggggcctca gtgaagctct
      181 cctgtcaggc ttctggatat tccctcactc actacttcat gcactgggtg agacaggccc
      241 ctggacaggg ccttgagtgg ataggactga tcacccctca caatgatcat aaagtctacg
      301 cacagaactt ccagggcaga gtcaccataa ctacggacac gtccacgagc acagtgtcca
      361 tggagctgag cagcctgaga tccgaagaca cagccgtata ctactgtgcg agaggggggg
      421 acatagaata ttgtactggt agtggttgtg gggagcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002910             423 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17285:23477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002910
VERSION     KCXD01002910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 423)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 423)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17285:23477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    61..421
                     /note="immunoglobulin heavy chain variable region"
     V_region        61..421
     V_segment       61..354
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>390
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61392.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       363..370
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       376..421
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        422..>423
                     /gene="IGHG"
BASE COUNT           81 a           99 c          139 g          104 t
ORIGIN      
        1 acatgggagt ttgtgctgag ctgggttttc cttgttgctc ttttgaaagg tgtccagtgt
       61 gaggtgcagc tggtggagtc tgggggcgac ttggcaaagc ctggggggtc cctgagactc
      121 tcctgcgctg cctctggatt cagcttcagt tactactaca tgagctgggt ccgccaggct
      181 ccagggaagg ggctggagtg gatctcgggt attgacagtg gtgggggtac cacatactat
      241 gcagactccg tgaagggcag attcaccatc tccagagaga acgccgagaa cacactgtat
      301 cttcaaatgg acagcctgac agctgaggac acggctgtct attactgtgc gagagtcgtg
      361 ggtggtagtg ctggatactt tgactactgg ggccagggag tcctggtcac cgtctcctca
      421 gcc
//
LOCUS       KCXD01002911             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11618:14100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002911
VERSION     KCXD01002911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11618:14100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..451
     V_segment       100..390
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61393.1"
                     /translation="CAGGSRRQPENW"
     D_segment       402..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           83 a          130 c          139 g          101 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctatgcaaga gcatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagact ctgtccctca cctgtgttgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggtata tcggtggtac tagtgggagt acctactaca acccctccct cgagagtcga
      301 gtcaccattt caacagacac gtccaagaat cacttctccc tgaagatgag ttctttaacc
      361 gccgcggaca cggccatgta tttctgtgcg ggcggaagtc ggcggcagcc ggagaactgg
      421 ggccagggag tcctggtcac cgtctcttca gcc
//
LOCUS       KCXD01002912             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12864:3818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002912
VERSION     KCXD01002912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12864:3818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61394.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          118 a          120 c          144 g          130 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga gacttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtgcctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggaattaaca
      301 ttggcggtga cccatactac ccagactctg ttaagggtcg attcaccatc tccagagaca
      361 atgccaagaa ctccttgtat cttcagatga acaatctgag agctgaggac actgctgtgt
      421 attattgtgt gaggggaatg gataactacc actacagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002913             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12715:16986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002913
VERSION     KCXD01002913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12715:16986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..465
     V_segment       108..401
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61395.1"
                     /translation="CTRRPWNADYFDYW"
     D_segment       408..414
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          111 a          107 c          140 g          109 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagtgt ccagtgtgag gtacaattgg
      121 tggagtctgg aggaggtttg ggtcagcctg gggggtccct gagactctcc tgtgaagctt
      181 ctggattcat cttcagtaat tatggcatgc actgggtccg ccaggctcca gggaaggggc
      241 tggagtgggt ggcagttata tcgtatgatg taagtaagac atactacgca gactctgtga
      301 aggaccgatt caccatctcc agagacaatt ctaagaacat gctatatctt caaatgagca
      361 acctgaaatt ggaggacacg gccgtgtatt tctgtacgag acgcccttgg aacgctgact
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002914             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15177:8260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002914
VERSION     KCXD01002914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15177:8260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61396.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       408..415
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           84 a          143 c          138 g          102 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acatcctgtg caagaacatg aagcgcctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tcctggagct ggatccgcca gcccccaggc aagggtctgg
      241 agtggattgg acatgtcagt ggtagtagtg ggagcaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agcgccagtt ctccctgagg ctgatttctg
      361 tgaccgccgc ggacacggcc gtctatcatt gtgcgagagt ccggggcgtg actatctatt
      421 actttgacta ctggggccag ggagccctgg tcaccgtcgc ctcagcc
//
LOCUS       KCXD01002915             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20099:18097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002915
VERSION     KCXD01002915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20099:18097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61397.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       402..413
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           95 a          138 c          137 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cagtaactac tggagctgga tccgccagtc cccaggaaag ggactggagt
      241 ggattggacg tatttctggg agtggtggga gcaccgtcta caacccctcc ctcaagagtc
      301 gagtcacctt ttcaacagac acgtccaaga acgagatctc cctgaaagtg acctctgtga
      361 ccgccgcgga cacggccgta tattattgtg cgacagccgg atatagcagc agcgaaagct
      421 tctacggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002916             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21700:18305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002916
VERSION     KCXD01002916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21700:18305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61398.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          135 c          136 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccttcagc ggttactatt ggagctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggtat atcagtgcta gtagtgggag taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaatta ccatttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagagagaag tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtccaggtc accgtctcct cagcc
//
LOCUS       KCXD01002917             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11619:15538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002917
VERSION     KCXD01002917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11619:15538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61399.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       442..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          104 a          125 c          161 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcgca
      181 gcctgggggg tccctgaaac tcccctgcgc agcctctgga ttcagcttca gctacttcta
      241 catgagctgg gtccgccagg ctccaggaaa ggggctggag tggatctcag ggattgacag
      301 tggtgggggt gacacattct atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aggacactgt atcttcaaat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gcgaggtcta ctgggagcta caggggatac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01002918             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22732:6909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002918
VERSION     KCXD01002918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22732:6909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61400.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       444..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          117 c          151 g          119 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcaact ggtggagtct ggaggaggct tggttcggcc
      181 gggggggtcc ctgagactct cctgtacagc ctctggattc accttcagta attttggcat
      241 ccactgggtc cgccaggctc cagggaaggg cctggagtgg gtggcagtta tatcgtctga
      301 tgaaagtaag aaatactatg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atggtttatc ttcagatgaa caacctgaag ttggacgaca cggccgtcta
      421 ttactgtgcg agagacgcat ttggcagcgg ctgtgacttc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002919             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10853:9171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002919
VERSION     KCXD01002919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10853:9171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61401.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       443..448
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          115 c          151 g          118 t
ORIGIN      
        1 acatggggtg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgaac tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg acgtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta cctttggcat
      241 acactgggtc cgccaggctc cagggaaggg gctggactgg gtggcagtta tttcgtatga
      301 tgaaactaag aaatacttcg cagactctgt gagggaccgg ttcaccatct ccagagacaa
      361 ttccaaaaac atggtatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtata
      421 ttactgtgcg agagatgtca ggggaacggg gtttgacttc tggggccagg gagccctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01002920             419 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7776:17721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002920
VERSION     KCXD01002920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 419)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 419)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7776:17721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    39..417
                     /note="immunoglobulin heavy chain variable region"
     V_region        39..417
     V_segment       39..332
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <324..>386
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61402.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       336..346
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..417
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        418..>419
                     /gene="IGHG"
BASE COUNT           86 a          111 c          132 g           90 t
ORIGIN      
        1 acatgggggt ggtggcagca gctacaggtg cccagtctca ggtccagctg gtgcagtccg
       61 gggctgagat ggagaagcct ggggcctcag tgaagctctc ctgtaaggct tctggataca
      121 gcttcagcat ctatgtcatc agttgggtgc gacaggcccc tggacaaggg cttgagtgga
      181 tgggaggcat cttccctctt gttggtacaa caaactacgc acagaagttc cagggcagag
      241 tcacgattac cgcggacacg gccacaagca cagcctacat ggacctgagc agcctgggat
      301 ctggggacac ggccgtgtat tattgtgcga gaggttactg tactggcaat ggttgtaacc
      361 ttactttcaa ccggctcgat gtctggggcc cgggagtccc ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002921             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:8712:16839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002921
VERSION     KCXD01002921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:8712:16839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61403.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           83 a          140 c          136 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tagtggtggg agcacctact acaactcctc cctccagagt
      301 cgcgtcacca tttcaaccga cacgtccaag aaccagttct ccctaatact gacctctgtg
      361 accgccgcgg acacggccct ctattactgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002922             314 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12003:20582
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002922
VERSION     KCXD01002922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 314)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 314)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12003:20582"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..312
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..312
     V_segment       153..248
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>281
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61404.1"
                     /translation="CARYEEGGTAFEYW"
     D_segment       261..265
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       269..312
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        313..>314
                     /gene="IGHG"
BASE COUNT           63 a           90 c           93 g           68 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggccctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggcgaagc cttcggagac cccgagtcac catttcaaca gacacgtcca
      181 agaatcagtt tttcctgaac ctgagttctg tgaaggccgc ggacaccgcc gtgtattatt
      241 gtgccagata tgaagagggc ggaaccgcct ttgagtactg gggccaggga gtcctggtca
      301 ccgtctcgtc agcc
//
LOCUS       KCXD01002923             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:22974:20781
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002923
VERSION     KCXD01002923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:22974:20781"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61405.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       414..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           97 a          138 c          123 g          108 t
ORIGIN      
        1 acatggggtc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggctat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 aatcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gctctgtgac
      361 cgccgcggac accgccgtat attactgtgt cagatatgaa gatgaatcca ttaactacca
      421 ctttgactat tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002924             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:11986:17341
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002924
VERSION     KCXD01002924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:11986:17341"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..423
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61406.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       439..446
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          121 c          143 g          127 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggga ttcccaggtg ttttcattca gagatcagga
       61 ctgaacacac aggactcacc atggagttta tgctgagctg ggttttcctt gtttctatat
      121 taaaaggtgt ccagtgtgtg gagcatctgg tggagtctgg gggaggcttg gtacagcctg
      181 gggcgtccct gagactctcc tgtgcagcct ctgaattcac cttcagtggc tatgacatgc
      241 actgggttcg ccaggctcca gggaagggtc tagaatggct atcaggtatt aacattggcg
      301 gtgacccata ctacccagac tctgtgaagg gtcgattcac catctccaga gacaacgcca
      361 agaactcctt gtatcttcaa atgaacaacc tgagacctga ggacactgct gtgtattatt
      421 gtgtgagggg gatggataac taccacttca gtaatacgga ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002925             360 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:21103:7262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002925
VERSION     KCXD01002925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 360)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:21103:7262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..358
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..358
     V_segment       8..282
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <274..>327
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61407.1"
                     /translation="CARDAGVGAIALYYYDYW"
     D_segment       291..296
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       311..358
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        359..>360
                     /gene="IGHG"
BASE COUNT           75 a          104 c          103 g           78 t
ORIGIN      
        1 acatgggcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcac ctgcactgtc
       61 tctggtggct ccttcagcgg ttactactgg atctggatcc gccagccccc agggaaggga
      121 ctggagtgga ttgcgggtgt cggtggtggt agtgggatca ccgaatacaa tcccaccctc
      181 aaaagtcgag tcactatttc aagagacacg tccaagaacc aattctccct gaaactgacc
      241 tctatgaccg ccgcggacac ggccatttat tactgtgcga gagatgcggg agtgggggcc
      301 atagcccttt actactatga ctactggggc cagggagtct tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002926             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17651:9887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002926
VERSION     KCXD01002926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17651:9887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61408.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       448..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          114 c          153 g          123 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgtt
      301 tgatgatagt aagaaatact acgtagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cttacggtag tggctgggac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002927             310 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17845:6408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002927
VERSION     KCXD01002927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 310)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 310)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17845:6408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..308
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..308
     V_segment       8..237
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <230..>277
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61409.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       250..258
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       267..308
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        309..>310
                     /gene="IGHG"
BASE COUNT           64 a           83 c           93 g           70 t
ORIGIN      
        1 acatgggtgc gctgtctctg gtggctctat cagcagtagt tactgcagct ggatccgcca
       61 gaccccaggg aagggactgg agtggattgg gtatatctat gggagtgata gtagtaccaa
      121 ctacaacccc tccctcaaga gtcgagtcac cctgtcagtg gacacgtccg agaaccagtg
      181 ctccctgaag ctgagctctg tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc
      241 gggtatagaa gtggttgcct acagcattga ctactggggc cagggagtcc tggtcaccgt
      301 ctcctcagcc
//
LOCUS       KCXD01002928             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10161:3973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002928
VERSION     KCXD01002928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10161:3973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61410.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          111 c          159 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcagctt cagtatcttt
      241 ggcatgcatt gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa gtaagaaata ctacacagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaaaatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattatt gcgcgagaga cgattttggc agcggcttag ggtactgggg ccagggagcc
      481 ctggtgaccg tctcctcagc c
//
LOCUS       KCXD01002929             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9074:16917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002929
VERSION     KCXD01002929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9074:16917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61411.1"
                     /translation="CAKGETATPYYGLDSW"
     D_segment       438..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          111 a          128 c          152 g          112 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag atgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatgcta
      241 tacactgggt ccgccaggct ccagggaagg gactggagtg ggtctcagct attagcactg
      301 gtggtaggac attctacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgagagc tgaggacacg gccatgtatt
      421 actgtgcgaa aggggaaaca gctacacctt actacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002930             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20626:10691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002930
VERSION     KCXD01002930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20626:10691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61412.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          115 c          152 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaggggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atattatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaagtt ggacgacacg gccgtgtatt
      421 tctgtgcgag agacgcattt ggcagcggct gtgactactg gggccggggc gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002931             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22564:9802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002931
VERSION     KCXD01002931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22564:9802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..490
     V_segment       139..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61413.1"
                     /translation="CTGGAYANLDYW"
     D_segment       439..443
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          108 a          123 c          155 g          106 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct ggactgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagatg gtggagtctg ggggcggctt ggcaaaacct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctactggatg
      241 aactgggtcc gccagactcc aggaaagggg ctggagtggg tctcagctat taattatgat
      301 gggggtagcg catactacgc agactccgtg aagggccgat tcaccatttc cagagacaac
      361 tcaaagagta cgctctccct gcaaatgagc agcctgagag cggaggacac ggccgtatat
      421 tactgtacgg gcggggcata cgctaacctc gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002932             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:10436:7991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002932
VERSION     KCXD01002932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:10436:7991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61414.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       443..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..512
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          118 a          122 c          152 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagt ctccagggga ggggctggaa tgggtggcgc ttatatcgta
      301 tgatggaact aagaaatact acgcagactc tatgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagtaa gcggtataac tgaaagttcc gttgaatact tcgagttctg
      481 gggccagggc gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002933             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17412:10699
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002933
VERSION     KCXD01002933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17412:10699"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61415.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       412..419
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          103 a          136 c          150 g          105 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctataga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgagga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacacgttc agcatctatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tgtaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgagggga gattgtactg
      421 atactgactg ctcttccgcg gggggcgcct ttgatttctg gggccaagga ctcagggtca
      481 ccgtctcttc agcc
//
LOCUS       KCXD01002934             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16161:19126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002934
VERSION     KCXD01002934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16161:19126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61416.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          118 c          151 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gagatgtcca ctgtgaggtg cacctggtgg aatctggagg aggttcggct
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
      241 ggcattcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagacata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002935             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20374:9659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002935
VERSION     KCXD01002935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20374:9659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61417.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          146 c          146 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 cccctgtaag gtttccggat acaccgtcag cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agcgcctggt ccaacctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002936             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21421:14113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002936
VERSION     KCXD01002936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21421:14113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61418.1"
                     /translation="CVRDAFGSGFDVW"
     D_segment       443..448
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          111 c          159 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      301 atgatgaaaa taagaagtac tacgcagact ctgtgaaggg ccgattcacc gtctccagag
      361 acaattccaa gaatatgata tatgttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gcatttgggt cggggttcga tgtctggggc ccgggagtcc
      481 tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01002937             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:10503:19881
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002937
VERSION     KCXD01002937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:10503:19881"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61419.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       410..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          131 c          138 g          105 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc agggctggtg aagcctccgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctctat cagcagtagt tactggagct ggatccgcca gaccccaggg aagggactgg
      241 agtggattgg gtatatccat gggagtgata gtagtaccaa gtacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaatcaatg ctccctgaag ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc gggtatagaa gtggttgcct
      421 acagtattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002938             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23045:7566
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002938
VERSION     KCXD01002938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23045:7566"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61420.1"
                     /translation="CAREYCTTHDCAGFFDYW"
     D_segment       415..426
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          134 c          139 g          107 t
ORIGIN      
        1 acatggggac aaaacaaccg catccctcct ctaaagaagc ccctgggagc acagctcatc
       61 accatggact ggacctggag gctcctcttt gtggtggcag cagctacagg tgtccagtcc
      121 caggtccagt tggtgcagtc cggggctgag gtcaagaagc ctggggccgc agtgaaggtt
      181 tcctgcaagg cttctggatt caccctcgac aactatggta tcaactgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggagtg atcatccccc atgttggtat aataaattac
      301 ggtgagcggt tccaggacag agtcacgatt agcgcggaca cgtccatgaa tatagcctac
      361 atggacctga ccagcctgaa atccgacgac acggccatct atttctgtgc gagagaatac
      421 tgtactactc atgattgcgc cggcttcttt gactactggg gccagggagt cctggtcacc
      481 gtctcttcag cc
//
LOCUS       KCXD01002939             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12675:18946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002939
VERSION     KCXD01002939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12675:18946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61421.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       454..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          124 c          157 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtcttgccag
      301 tggtggggat agcacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagttgaag acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcattatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002940             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24323:5692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002940
VERSION     KCXD01002940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24323:5692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61422.1"
                     /translation="CARDPQWQLELLYFDSW"
     D_segment       417..423
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           95 a          144 c          131 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctcgttca gcaattccta ctggagctgg atccgccagc ccccagggaa ggggctggaa
      241 tggattggat atatcagtgg tgatagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gaactctgtg
      361 accaccgcgg acacggccgt gtattactgt gcgagagacc cccagtggca gttggagctc
      421 ctctactttg actcctggag ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002941             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9126:5133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002941
VERSION     KCXD01002941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9126:5133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61423.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       266..278
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..320
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           77 a           73 c           95 g           77 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgaagcctct ggattcacct tcagtagtaa
       61 tggcatgcac tgggtccgcc aggttccagg gaaggggctg gagtgggtgg cagttatatc
      121 gtatgatgta agtaagaaat actacgcaga ctctgtgaag gaccgattca ccatctccag
      181 agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtgttctac tgtgtgagag actcttatgg gagtggtttg gatgcctggg gccaaggggt
      301 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01002942             276 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:26110:16369
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002942
VERSION     KCXD01002942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 276)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 276)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:26110:16369"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..274
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..274
     V_segment       8..194
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <193..>243
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61424.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       209..223
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       227..274
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        275..>276
                     /gene="IGHG"
BASE COUNT           73 a           67 c           70 g           66 t
ORIGIN      
        1 acatgggggg tccgccaggc ttctgggaaa ggactggagt ggattggcta tattagaagc
       61 caatataaca atttcgcgac agaatacgcc ccatcggtga aaggcagatt caccatctcc
      121 agagatgatt caaagaacac gctatttctg caaatgagta gcctgaaaac cgaggacacg
      181 gccgtgtatt actgcaccac ccattttggt ggtaattatt acttggacta ctttgtctac
      241 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002943             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18344:3023
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002943
VERSION     KCXD01002943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18344:3023"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..474
     V_segment       111..404
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61425.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       408..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           98 a          134 c          134 g          110 t
ORIGIN      
        1 acatggggga tgggaaatgc tctctgagag tcatggacct cctgtgcaag aacatgaagc
       61 acctgtggtt cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc
      121 tgcaggagtc gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcggtg
      181 tctctggtga ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg
      241 gactggagtg gattgggtat atctctggtg cttatgggag caccagctac aacccctccc
      301 tcaagagtcg agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga
      361 gttctgtgac cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca
      421 ttaactacca ctttgactgc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002944             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:25209:7969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002944
VERSION     KCXD01002944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:25209:7969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61426.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtaca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc cgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002945             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18427:8968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002945
VERSION     KCXD01002945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18427:8968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61427.1"
                     /translation="CTRGIDNYHFSNTEFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          119 a          112 c          147 g          129 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagttg gtggaatctg ggggaggatt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaatgcc
      361 aagaactccg tatatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtacaaggg ggatagataa ctaccacttt agtaatacgg agtttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002946             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15085:19441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002946
VERSION     KCXD01002946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15085:19441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..293
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..293
     V_segment       8..219
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <212..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61428.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       226..241
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       243..293
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        294..>295
                     /gene="IGHG"
BASE COUNT           74 a           79 c           82 g           60 t
ORIGIN      
        1 acatgggacc ttcaccgaat tatccataca ctgggtgcga caggcccctg gaaaagggct
       61 tgagtggatg ggaagtgttg atcctttata tggtgaaatg atacacacag aacagttcca
      121 gggcagagtc accctgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag
      181 cctgagatct gaggacatgg ccgtgtatta ctgtgcgagt ggccctagcg gcagctggaa
      241 cgactggtac ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01002947             528 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16759:12723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002947
VERSION     KCXD01002947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16759:12723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..526
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..526
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>495
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61429.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       452..471
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       484..526
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        527..>528
                     /gene="IGHG"
BASE COUNT          113 a          132 c          156 g          127 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg caactggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttac
      241 gacatgacct gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 tacactggta aaaccatata ctactctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaactctct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattatt gttctagagc ggcttacgaa catgatgacg gttactatta cgtcggcagg
      481 ttttttgact gctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002948             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17340:19186
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002948
VERSION     KCXD01002948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17340:19186"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61430.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       411..420
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          144 c          136 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggct
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cctcagagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcggt agttactggt ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggaa atagcggtag tacctactac agcccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccacctctcc ctgaagctga actccgtgac
      361 caccgcggac acggtcgtgt atttctgtgc gaacgtctta ggcccctggg gcagctggtc
      421 acactacttt gagtactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002949             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8091:10359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002949
VERSION     KCXD01002949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8091:10359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..348
     V_segment       8..257
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61431.1"
                     /translation="CARELSPYDYVWSDFYSYYFDYL"
     D_segment       273..279
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           70 a          106 c           91 g           83 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ctgtctctgg tggctccttc agcggttact
       61 actggagctg gatccgccag cccccaggga agggactgga gtggattggg catatcagtg
      121 ggactagtgg gagcaccgac tacaacccct ccctcaaaag tcgagtcacc atttcaacag
      181 acacgtccaa gagtcacttc tccctgaaac tgagctctgt gaccgccgcg gacacggccg
      241 tgtattactg tgcgagagag ctttccccct acgactatgt ttggagtgat ttttactctt
      301 actactttga ctacttgggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002950             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16066:3443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002950
VERSION     KCXD01002950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16066:3443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61432.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          117 a          112 c          149 g          129 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagttg gtggaatctg ggggaggatt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaatgcc
      361 aagaactccg tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtgcaaggg ggatagataa ctaccacttt agtaatacgg agtttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002951             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12679:18257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002951
VERSION     KCXD01002951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12679:18257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61433.1"
                     /translation="CARDGIAAAGVDYW"
     D_segment       403..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          139 c          137 g           97 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggccctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcatctgcac tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatcggtgg tcataatggg aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagtt gacctctgtg
      361 accgccgcgg acacggccat atattactgt gcgcgcgatg gcatagcagc ggcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002952             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12874:6204
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002952
VERSION     KCXD01002952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12874:6204"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..279
     V_segment       7..194
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <186..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61434.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       218..226
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       232..279
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           67 a           78 c           83 g           53 t
ORIGIN      
        1 acatgggggt gcgacaggcc cctggacaag ggcttgagtg gatgggaggg atcatccctc
       61 ttgttgattt aacacactac gcacagaagt tccagggcag agtcacgatt accgcggaca
      121 cgcccacaag cacagcctac atggagctga gcagcctgag atctgaggac acggcctttt
      181 attactgtgc gagagggaca acccacctcg agatggcaac tggaatcgga gactactttg
      241 actcctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002953             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9409:22739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002953
VERSION     KCXD01002953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9409:22739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61435.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       419..425
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          138 c          142 g          100 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaaa acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattattg tgcgagaggt
      421 gtgacagcag acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01002954             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:17975:10383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002954
VERSION     KCXD01002954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:17975:10383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61436.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          109 a          124 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttgggac tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gacatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtctattact gcactaggaa ccggaatact gttatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002955             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11117:6972
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002955
VERSION     KCXD01002955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11117:6972"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61437.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          121 c          153 g          127 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggtgac tactggatgt
      241 actgggttcg ccagacacct gaacaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtcctagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaag cacattatat cttcagatgg acagcctgaa aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 ggggagtcct agtcaccgtc tcctcagcc
//
LOCUS       KCXD01002956             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20289:4419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002956
VERSION     KCXD01002956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20289:4419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..483
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61438.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       425..435
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..483
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>490
                     /gene="IGHG"
BASE COUNT          112 a          137 c          140 g          101 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctcct ggtggcggca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaagt gaagaagcct ggggcctcag tgagggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatg cactggctgc gacaggcccc
      241 tggaaaaggg cttgagtggt tgggatgtgt tgattataaa tatgatgaag aaatatacgc
      301 agacaatttc cagggcagag tcaccatgac cgaggacacg tccacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat ttctgtgcgg cgggccttgg
      421 gggatattta ctgcttactg aatatttcca gttctggggc cagggcgccc tggtcaccgt
      481 ctcttccgcc
//
LOCUS       KCXD01002957             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13636:11116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002957
VERSION     KCXD01002957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13636:11116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61439.1"
                     /translation="CVQGEIFGVDLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          111 a          117 c          158 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgtcag gctccaggaa aggggctaga gtgggtctca actattaata
      301 gtggtgggga taacacatat tacgcaaact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattattg tgttcaaggg gaaatttttg gagtggattt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01002958             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16696:3815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002958
VERSION     KCXD01002958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16696:3815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61440.1"
                     /translation="CARYDDDDYGYYYLDYW"
     D_segment       407..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          135 c          131 g          113 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tggctccatc agcaatagtt actggttctg gatccgccag cccccaggga aggggctgga
      241 gtggattggc tatatctatg gttctactgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcagc atttcaacag acacgtccga ggaccagttc tccctgaagt tgagttctgt
      361 gaccgccacg gacaccgccg tgtattattg tgcgagatat gacgacgatg attacggtta
      421 ctattacctt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002959             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12819:12930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002959
VERSION     KCXD01002959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12819:12930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..441
     V_segment       78..371
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61441.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       385..390
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..441
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           89 a          107 c          137 g          110 t
ORIGIN      
        1 acatggggac agaacaaacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
       61 tgaaaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcaaagcctg
      121 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagtttc tactacatga
      181 gctgggtccg ccagcctcca gggaagggtc tggagtggat ctcaggtatt aacgctggtg
      241 gggatggcac atactctaca gactccgtga agggcagatt caccatctcc agagagaacg
      301 ccaagaacac actgcatctt caaatggaca gcctgagaac tgaggacacg gctgtctatt
      361 tctgtgtgag agatcgacgt gttcagtcgt tatcctggtt cgatgtctgg ggcccgggag
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002960             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:25362:7476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002960
VERSION     KCXD01002960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:25362:7476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61442.1"
                     /translation="CARGRSGGVWPNSFDYW"
     D_segment       427..436
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          132 c          145 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 ccccaggaaa agggcttgag tggatgggaa gtgttgatcc tgtatatggt gaaataattg
      301 tcgcagagaa tttccaggac agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggaact gagcagcctg gaatctgagg acacggccgt gtattactgt gcgagaggga
      421 ggagtggtgg tgtctggccg aactcctttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01002961             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9797:13340
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002961
VERSION     KCXD01002961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9797:13340"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61443.1"
                     /translation="CVRDAYGGGWDSW"
     D_segment       450..458
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          117 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga gtgggtggcg gttatatcgt
      301 ttgatgatag taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaga tgaacaacct gaaattggag gacacggccc
      421 tttattactg tgtgagagat gcttacggtg gtggctggga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002962             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10952:10381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002962
VERSION     KCXD01002962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10952:10381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61444.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       448..456
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          115 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cacacggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgagg ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcgttcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaaa taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaccatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gtcagaggcg gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002963             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17158:11878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002963
VERSION     KCXD01002963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17158:11878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61445.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          142 c          135 g           95 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggac ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01002964             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:25987:11088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002964
VERSION     KCXD01002964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:25987:11088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61446.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          109 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagttgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      301 ttgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002965             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14903:19452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002965
VERSION     KCXD01002965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14903:19452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61447.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          117 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01002966             308 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17417:11393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002966
VERSION     KCXD01002966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 308)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 308)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17417:11393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    159..306
                     /note="immunoglobulin heavy chain variable region"
     V_region        159..306
     V_segment       159..241
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <234..>275
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61448.1"
                     /translation="CAREGISASGVDYW"
     D_segment       245..251
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       267..306
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        307..>308
                     /gene="IGHG"
BASE COUNT           55 a           92 c           98 g           63 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc accagacacg tccaaagagc
      181 agttctccct gaggctgagg tctgtgaccg ccgcggacac ggccgtgtat tactgtgcga
      241 gggaggggat atcagcgtcg ggggtcgact actggggcca gggagtcctg gtcaccgtct
      301 cctcagcc
//
LOCUS       KCXD01002967             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10977:21984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002967
VERSION     KCXD01002967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10977:21984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61449.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          118 c          150 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 cttccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatctcgaa
      301 cgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tttctagaga
      361 caattccatg aacatgctat ttcttcaaat gaacaacctg aacttggacg acacggccgt
      421 ctattactgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002968             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19305:12650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002968
VERSION     KCXD01002968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19305:12650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61450.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       412..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           99 a          136 c          136 g          110 t
ORIGIN      
        1 acatgggggc tccctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcgatg tctctggtta
      181 ctccatcagc agtggttact actactgggg ctggatccgt cagcccccag ggaagggtct
      241 ggagtggatt gggtatatag gtggtagtac tgggacctcc tactacaacc ccgccctcaa
      301 gagtcgagtt accatttcaa aagacacgtc caagaaccag ttttccctga aggtgagctc
      361 tgtgaccgcc gcggacacgg ccgtttatca ctgtgcgaga catggaggtt tctatagtgc
      421 gactgacaag tcaacatttg acaactgggg ccaggcagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01002969             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18360:13981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002969
VERSION     KCXD01002969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18360:13981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61451.1"
                     /translation="CTAHYSGSYYIDYFAYW"
     D_segment       441..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          119 a          121 c          151 g          123 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggactc accttcagtg actatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg gttggctata ttagaagcac
      301 atatagaaat tacgcgacag aatacgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aggaacacgc tatatctgca aatgagcagc ctggaaatag aggacacggc
      421 cgtgtattat tgcactgccc actatagtgg tagttattac atagactact ttgcctactg
      481 gggccaggga gacctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002970             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20904:4756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002970
VERSION     KCXD01002970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20904:4756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61452.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          117 c          149 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtcactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01002971             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12167:11148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002971
VERSION     KCXD01002971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12167:11148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61453.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          142 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggacc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatgtctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01002972             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9381:15401
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002972
VERSION     KCXD01002972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9381:15401"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61454.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          124 c          159 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaatt ggacagcctg agagctgagg acacggctgt
      421 ctactattgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01002973             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14392:12311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002973
VERSION     KCXD01002973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14392:12311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61455.1"
                     /translation="CASGPSGYWNDWYFDIW"
     D_segment       431..441
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          120 a          141 c          135 g           96 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctagtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaactat ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttca gtggatggga agtgttgatc ctgcatttgg tgaaatgata
      301 aacgcagaga agttccagga cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tatatggagc tgagcagcct gagatctgag gacacggccg tgtattattg tgcgagtggc
      421 cctagcggct actggaacga ctggtatttc gatatctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01002974             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23380:6016
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002974
VERSION     KCXD01002974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23380:6016"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61456.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       443..455
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          111 c          156 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagtaacgg
      241 catgcactgg gtccgccagg ttccagggaa ggggctggag tgggtggcag tgacatcgtt
      301 tgatgaaagt aagaaatact acgcagactc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagact cttatggaag tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01002975             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21021:4605
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002975
VERSION     KCXD01002975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21021:4605"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61457.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          112 c          155 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc atttggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtcgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcgtctgga ttcaccttca gtaactttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgca
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcaccc tttccagaga
      361 caactccaag aaaatgctat atcttcaaat gaacgacctg aaattggggg acacggccgt
      421 gtattattgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01002976             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20050:20559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002976
VERSION     KCXD01002976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20050:20559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61458.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          112 a          119 c          155 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcaa ttattactat
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaatagt
      301 ggtggggaaa gcacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga aaacagtata tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgtacag tccttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002977             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18394:11025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002977
VERSION     KCXD01002977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18394:11025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61459.1"
                     /translation="CARYDDDDYGYYYLDYW"
     D_segment       406..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           92 a          135 c          131 g          113 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 ggctccatca gcaatagtta ctggttctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatctatgg ttctactggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcagca tttcaacaga cacgtccgag gaccagttct ccctgaagtt gagttctgtg
      361 accgccacgg acaccgccgt gtattattgt gcgagatatg acgacgatga ttacggttac
      421 tattaccttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01002978             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16060:8710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002978
VERSION     KCXD01002978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16060:8710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61460.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       414..425
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..483
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          101 a          141 c          137 g          106 t
ORIGIN      
        1 acatggggtc acatgggaaa tgttctctga gagtcacgga catcctgtgc aagaacatga
       61 agcacctgtg gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc
      121 agctgcagga gtcgggccca ggactgctga agcctttgga gaccctgtcc ctcacctgcg
      181 ctgtttctgg tggctccatc agcagtaact actggagctg gatccgccag tccccaggga
      241 agggactgga gtggattgga cgtatctctg gtagtggtgg gaacaccgtc tacaacccct
      301 ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccagatc tccatgaaag
      361 tgacctctgt gaccgccgcg gacacggccg tgtattattg tgcgacagcc ggatatagca
      421 gcagcgaaag cttctacggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01002979             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:26668:6860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002979
VERSION     KCXD01002979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:26668:6860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..452
     V_segment       95..388
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61461.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       397..403
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           90 a          141 c          129 g           94 t
ORIGIN      
        1 acatggggtg agagtcacgg acctcctgtg caagaacatg aggcacctgt ggttcttcct
       61 cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctacagg agtcgggccc
      121 aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtgactccat
      181 cagcagtaac ttctggagct ggatccgcca gcccccaggg aagggactgg agtggattgg
      241 acgtatctat ggtagtactg atagcaccag ctacaacccc tccctcacga gtcgagtcac
      301 catttcaaca gacacgtcca agaaccagtt ctccctgaag ctgacctctg tgaccgccgc
      361 ggacacggcc gtgtattact gtgcgagaga tgcgggaact gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01002980             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12887:18759
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002980
VERSION     KCXD01002980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12887:18759"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61462.1"
                     /translation="CVRDRRVESLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          101 a          127 c          158 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtgggggc aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaactccaag accacactgt atcttcacat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gtcagagatc gacgtgtaga gtcgttatcg tggttcgatg tttggggccc
      481 gggagtcctg gtcgccgtct cctcagcc
//
LOCUS       KCXD01002981             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16280:20126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002981
VERSION     KCXD01002981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16280:20126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61463.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       446..452
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          120 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgccgact ctttgaaaga ccgattcacc atatccagag
      361 acgactccag gaacatgcta tatcttcaac tgaacaacct gaaattggac gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct gggggcttga ctactggggc cagggagtcc
      481 tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01002982             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:23409:10406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002982
VERSION     KCXD01002982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:23409:10406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61464.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          113 c          153 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagcacc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggctgttata tcgtatgatg
      301 aaactaagaa atactacgga gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agacgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002983             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18406:12221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002983
VERSION     KCXD01002983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18406:12221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61465.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       433..445
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          142 c          151 g           98 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagta
      181 aaggtctcct gccaggtttc cggatacacc ttcagtgaaa tgtccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggatgtgttg ctcctggaaa tggtgaaata
      301 atacacgcag agaacttcca gggcagagtc accatggccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagtag cctgagatct gacgacacgg ccgtatatta ctgtgcgaca
      421 gggaggttcg ggagcagcgt ctggtccagc ctcttctacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01002984             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20989:14313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002984
VERSION     KCXD01002984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20989:14313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61466.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          139 c          139 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctggccctc acctgcgctg tctctggtgg
      181 ctccatcagt ggttactggt ggggctggat ccgccagtcc ccagggaggg ggctggaatg
      241 gattggattt ttcggtggta gtggtgggaa cacctactac aagtcctccc tccagagtcg
      301 agtcaccatt tcagccgacc cgtccaagaa ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gcgggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01002985             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19978:8672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002985
VERSION     KCXD01002985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19978:8672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61467.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          119 a          145 c          133 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgaatt atcattgcac tgggtgcgcc
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga ccctgcatat ggtgaaatga
      301 tacacacaga gatattccag ggcagaatca ccatgaccga ggacacgtca acagacacag
      361 cctacatgga gctaagcagc ctgagatctg aggacacggc cgtttattac tgtgcgatat
      421 catccagcgg cacctggcta ttctggtact tcgatgtctg gggccctggc tccccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01002986             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8556:19540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002986
VERSION     KCXD01002986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8556:19540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61468.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          114 c          154 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtttctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtctgtaatt tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacat actatatctt cagatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002987             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17326:18466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002987
VERSION     KCXD01002987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17326:18466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..496
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61469.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       448..456
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          112 a          115 c          151 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcatc tggaggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgtaa cctctggatt caccttcagt agctatggca
      241 tgcactgggc ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      301 atggaagtaa gatttactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctctat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagaggag aaatttggct acagttttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcggcc
//
LOCUS       KCXD01002988             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14973:9528
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002988
VERSION     KCXD01002988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14973:9528"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61470.1"
                     /translation="CVRESYSGNYYFNRFDVW"
     D_segment       402..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          135 c          135 g          110 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccagtag caataattac tggagctgga tccgccagtc cccagggaag ggactggagt
      241 ggattggaca tatctctggt agtggtggga ggaccgacta caacccctcc ctccagagtc
      301 gagtcaccat ttcaactgac acgtccaaga gccagttctc cctgaagttg agctctgtga
      361 ccgccgcgga cacggccgtc tattactgtg taagagagtc atatagtggt aattattact
      421 tcaaccggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01002989             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6538:18656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002989
VERSION     KCXD01002989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6538:18656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61471.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          118 c          148 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcggc
      181 ctggggggtc cctgagactc tcctgttcag cctctggatt caccttcagt aattttggca
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa gaaatactat gcagactctg tgaaggaccg attcaccctc tccagagaca
      361 attccaagaa tatactatat cttcaaatga acaacctgaa gttggaggac acggccgtct
      421 attactgtgc gagagacgca tatggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002990             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12946:10635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002990
VERSION     KCXD01002990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12946:10635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..456
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61472.1"
                     /translation="CASGSRRQPDKW"
     D_segment       407..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..456
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           86 a          137 c          142 g           93 t
ORIGIN      
        1 acatgggggg atgctctctg agagtcacgg acctcctgtg caagagcatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg atatatcggt ggaactagtg ggagcaccta ctacaacccc tccctcaaga
      301 gccgagtcac catttcaaca gacacgtcca agaaccaggt ctccctgaag ttgatcactg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagtgg aagtcggcgg cagccggata
      421 aatggggcca gggcctcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002991             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18561:3845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002991
VERSION     KCXD01002991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18561:3845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61473.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          138 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcttggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atctctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01002992             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24680:21312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002992
VERSION     KCXD01002992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24680:21312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61474.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          110 c          159 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
      241 gcatgcactg ggtccgccag gcgccaggga aggggctgga gtgggtggca gtgatatcgt
      301 ttgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01002993             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17845:11609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002993
VERSION     KCXD01002993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17845:11609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61475.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       440..444
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          121 c          146 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gctgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttcc tttggcatgc
      241 actgggtccg ccaggcaccg gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaactaacaa atactacgca gactctttga aagaccgatt caccatatcc agagacaact
      361 ccaagaacat actatatctt caactgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtgtat ggctcggggc ttgactactg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01002994             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6989:8731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002994
VERSION     KCXD01002994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6989:8731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61476.1"
                     /translation="CARERCTASSCAGFLDSW"
     D_segment       413..418
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          142 c          138 g           96 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtaca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa gtttcctgca
      181 aggcttctgg attcaccctc gacaactatg gcatcaactg ggtgcgccag gcccctggac
      241 aggggcttga gtggatggga gtgatcatcc ccctcattgg aataataaac tacgcacaga
      301 acgtccaggc cagagtcgcg atttccgcgg acacgtccac aaatacagcc tacatggaag
      361 tgcgcagcct aagatctgag gacacggcca tctattactg tgcgcgagaa cgttgtaccg
      421 ctagcagttg cgccggattc ctagactcct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01002995             402 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:25235:8137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002995
VERSION     KCXD01002995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 402)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 402)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:25235:8137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    46..400
                     /note="immunoglobulin heavy chain variable region"
     V_region        46..400
     V_segment       46..339
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <331..>369
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61477.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       342..347
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       358..400
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        401..>402
                     /gene="IGHG"
BASE COUNT           86 a           88 c          126 g          102 t
ORIGIN      
        1 acatgggggt ttttccttgt tgctatttta agaggtgtcc agtgtgaggt gcagctggtg
       61 gagtctggag gagacttggt tcagccgggg gggtccctga gactctcctg tggagcctct
      121 ggattcacct tcagtacttt tggcatgcac tgggtccgcc aggctccagg gaaggggctg
      181 gagtgggtgg cagttacatc gtctgatgaa agtaataaat actacgcaga ctctgtgaag
      241 gcccgattca ccgtctccag agacaattcc aagaacatgt tatatcttca aatggacaac
      301 ctgaaattgg aagacacggc cgtgtattac tgcgcgagag atgtctgggg gaggggattt
      361 gactattggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01002996             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16264:9795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002996
VERSION     KCXD01002996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16264:9795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61478.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       444..449
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          113 c          155 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagagca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt atttctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt aaatcgtttg
      301 atggaactaa gatatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgttt
      421 attactgtgt gagagatgcc tacgggagcg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01002997             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13485:13890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002997
VERSION     KCXD01002997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13485:13890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61479.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtac atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 aatcaccatt tcaacagaca cgtccaagaa ccagttttcc ctggggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaattacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01002998             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10587:7993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002998
VERSION     KCXD01002998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10587:7993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61480.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       414..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          143 c          137 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtct ttctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccctc accgaagtgt ccactcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtccacag acacagccta catggaattg
      361 agcagcctaa gatctgagga cacggccgtg tattactgtg cgattggacc taccggcagg
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01002999             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20018:14542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01002999
VERSION     KCXD01002999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20018:14542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..298
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..298
     V_segment       8..237
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61481.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       243..249
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..298
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        299..>300
                     /gene="IGHG"
BASE COUNT           73 a           76 c           81 g           70 t
ORIGIN      
        1 acatggggtg cagcctctgg attcaccttc agttcctctg gcatgcactg ggtccgccag
       61 gctccaggga aggggctgga gtggctgaca gttatatcgt atgatgaaac taagaaatac
      121 tacgcagact ctgtgaagga ccgattcacc atctccagag acaattccaa gaacatggta
      181 tatcttcaaa tgaacaacct gaaattggag gacgcggccg tttattactg tgcgagagat
      241 tcttacggtc gaggctttga ctcctggggc cagggagtcc cggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003000             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21846:8750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003000
VERSION     KCXD01003000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21846:8750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61482.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       442..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          117 a          113 c          158 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgttatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtcac tgagactctc ctgtgcagcc tctggattca ccttcaataa ctctggcatg
      241 cactgggtcc gccaggctcc agggaaggga ctggagtggg tggcacttat atctcatgat
      301 ggagataaga aatactacgc agactccgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctgtatct tcaaatgaac aacctaaaat tggatgacac ggccgtgtat
      421 tactgtgcga gagttggaga gggtagtggt ggtgcggagg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003001             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11468:7386
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003001
VERSION     KCXD01003001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11468:7386"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61483.1"
                     /translation="CVRDSSGSGFDYW"
     D_segment       443..448
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          113 c          149 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttctgg
      241 catacactgg gtccgcctgg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact atacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcacat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatt caagcggttc gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003002             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18107:13556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003002
VERSION     KCXD01003002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18107:13556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61484.1"
                     /translation="CAGGSRRQPENW"
     D_segment       403..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           82 a          132 c          140 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctatgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atcggtggta ctagtgggag tacctactac aatccctccc tcgagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa tctcttctcc ctgaagatga gttctttaac
      361 cgccgcggac acggccatgt atttctgtgc gggcggaagt cggcggcagc cggagaactg
      421 gggccaggga gtcctggtca ccgtctcttc agcc
//
LOCUS       KCXD01003003             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16333:15572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003003
VERSION     KCXD01003003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16333:15572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61485.1"
                     /translation="CARADIEAATSFDFW"
     D_segment       418..424
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          122 a          132 c          129 g          100 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtgcagtc tggggctgag attaagcagc ctggggcctc agtgaaactc
      181 tcctgcaagg cttctggata tatctacatg gactactaca tgcactgggt gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt ataatggtta caaagggtac
      301 gcacagaact tccaggacag agtcaccata attgcggaca cgtccacgag cacaggctac
      361 atggagctga gaagcctgag atatgaggac acaggcattt actactgtgc gagagcagat
      421 attgaagcgg ctacctcctt tgacttctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01003004             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:9031:18174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003004
VERSION     KCXD01003004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:9031:18174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61486.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          143 c          126 g          100 t
ORIGIN      
        1 acatggggtc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat ccctgcactg ggttcgacag
      241 gcccctggaa aagggcttga gtggatggga agttttaatc ctatatatgg tgaaatttta
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01003005             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:19617:11305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003005
VERSION     KCXD01003005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:19617:11305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61487.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           81 a          142 c          136 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga tgggactgga
      241 gtggattggc tttttcggtg gttatggtgg gaacacctac tacaacccct ccctccagag
      301 tcgagtcacc atttcaaccg acacgtccaa gacccagttc tccctgatac tggcctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat
      421 tgactactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003006             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21197:17283
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003006
VERSION     KCXD01003006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21197:17283"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61488.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       419..427
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          112 a          142 c          132 g          102 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggccg aagtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga cacaccttca gcgaattatc cattcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggag gttttgctcc tatatatggt gaaatcctac
      301 acacagacaa gttccagggc agagtcacct tgaccgagga cacgtctaca gacaccgcct
      361 atatggagtt gagcagcctg agatctgagg acacggccgt atattactgt gtggcggctg
      421 atagtggtta ccctttttac tacttcgata tctggggccc tggcacccca atcatcatct
      481 cctcagcc
//
LOCUS       KCXD01003007             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4781:13439
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003007
VERSION     KCXD01003007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4781:13439"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61489.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       408..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          106 a          144 c          134 g           93 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgag gtgatgcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gaattgtcca tgcactgggt gcgacaggcc
      241 ccaggaagag gccttgagtg ggtgggaagt gttgatcctg catatggtga aatgacgttc
      301 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagc
      361 agcctgagat ctgaggacac ggccgtatat tactgtgcga tcggccctag cggcagttgg
      421 aacgcctggt ccttcgatat ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01003008             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:3713:13663
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003008
VERSION     KCXD01003008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:3713:13663"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61490.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          141 c          130 g           91 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaggct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatggtaaag tagactacac
      301 acagaagttc cgagacagag tcaccatcac cgcggacatg tcgacagaga cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgactact ggggccaggg agccctggtc accgtttcct cagcc
//
LOCUS       KCXD01003009             552 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23678:6510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003009
VERSION     KCXD01003009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23678:6510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    190..550
                     /note="immunoglobulin heavy chain variable region"
     V_region        190..550
     V_segment       190..483
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <475..>519
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61491.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       493..502
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       503..550
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        551..>552
                     /gene="IGHG"
BASE COUNT          117 a          166 c          145 g          124 t
ORIGIN      
        1 acatggggag ggtgataact atgcaaattc aactggcggc ctccccactt aaacccaggg
       61 ctccccttca cagtgagtct ccctcaccgc acagctggga tctcagtgct tccttttctg
      121 tcctccacca cgatggggtc aactgccatc ctcaccctcc tactggctgt tctccaagga
      181 gtctgtgccg aggtgcagct ggtgcagtct ggagcagagg tgaaaaggcc cggggagtct
      241 ctgaagatct cctgtaagac ttctggatac agctttacca gttactggat cacctgggtg
      301 cgccagatgc ccgggaaagg cctggagtgg atgggggcga ttgatcctag tgattctgct
      361 accaaataca gcccgtcctt ccaaggccag gtcaccattt cagccgacaa gtccatcacc
      421 accgcctacc tagaatggag cagcctgaag gcctcggaca ccgccacgta tttttgtgcg
      481 aaaggtcccg gagtgattat taactacttt gactactggg gccagggagc cctggtcacc
      541 gtctcctcag cc
//
LOCUS       KCXD01003010             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19579:3724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003010
VERSION     KCXD01003010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19579:3724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..488
     V_segment       121..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61492.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       424..430
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>492
                     /gene="IGHG"
BASE COUNT          111 a          140 c          139 g          102 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccacc tggtgcagtc tggggctgaa gtgaagaggc ctggggcctc agttaaggtc
      181 tcctgcaagg tttccggata ctccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctg tgtatggtga agaaatacac
      301 gcagagaatt tccaggacag attcaccatg accgaggaca cgtctacaga cacagccttc
      361 atggagctga gcagcctgag acctgaggac acggccgtgt atttctgtgc ggcgggcctt
      421 gggggatatt tagttcttac tgaatacctc gaattctggg gccagggcgc cctggtcacc
      481 gtctcctccg cc
//
LOCUS       KCXD01003011             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21791:6295
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003011
VERSION     KCXD01003011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21791:6295"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61493.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       440..447
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          121 a          143 c          140 g          102 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggttaa gaagcctggg gcctcagtga
      181 gggtctcctg ccaggtttcc ggatacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgttga tcctgtaaat ggtgaaataa
      301 tacacgcaga caacttccag ggcagagtca ccatgaccga agacacgtct atagacacag
      361 cctacatgga actgagcagc ctgagatctg aggatacggc cgtatattac tgtgcgaccc
      421 acggaggcta tagtgacatc tggaactccc tgtactacgg tttggattcc tggggccaag
      481 gggtcttcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003012             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19667:15299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003012
VERSION     KCXD01003012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19667:15299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61494.1"
                     /translation="CARVLGYNNKYEVTRGRLDYW"
     D_segment       434..441
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          140 c          140 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaac ctctcctgca
      181 aggcttctgg ataccccttc aacatctatg ccatcaattg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg catgacaaac tacgcacaga
      301 agttccaggg cagagtcacc attaccgcgg acacgtccac aagtacagcc tacatagaac
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagagtc ttagggtaca
      421 ataacaagta cgaagttacc aggggccgtc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003013             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13748:17977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003013
VERSION     KCXD01003013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13748:17977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61495.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       426..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           99 a          148 c          131 g          107 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgca actggtacag tctggaccag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga taccgcttta ccagctactg gatcacctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatggggg cgattgatcc cggtgattct gctaccaaat
      301 acagcccgtc cttccaaggc caggtcacca tttcagccga caagtccatc accaccgcct
      361 acctggagtg gagcagcctg aaggcctcgg acaccgccac gtattactgt gcgaaaggtc
      421 ccggagtgat tattaactac tttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003014             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13867:3867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003014
VERSION     KCXD01003014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13867:3867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61496.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       443..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          110 c          153 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcga
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cttctggatt caccttcagt agttatggca
      241 tgcactgggt ccgcctggct ccggggaagg ggctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa gaaatactac ggagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catactatat cttcaaatga acaacctgaa attgaaggac acggccgtat
      421 actactgtgg gagagatgat aatggggtga ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003015             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:8853:8831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003015
VERSION     KCXD01003015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:8853:8831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..430
     V_segment       76..369
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61497.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       380..388
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..430
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT           94 a           92 c          139 g          107 t
ORIGIN      
        1 acatgggggg gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
       61 agaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt tcagcctggg
      121 gggtccctga gactctcctg tgcagcctct ggattcagct tcagtatctt tggcatgcac
      181 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatgtc gaatgatgga
      241 agtaagaaat actacacaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      301 aagaaaatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattat
      361 tgcgcgagag acgattttgg cagcggctta gggtactggg gccagggagc cctggtgacc
      421 gtctcttcag cc
//
LOCUS       KCXD01003016             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17995:10445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003016
VERSION     KCXD01003016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17995:10445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61498.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          116 c          149 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg aggcttggtg
      181 caacctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa ataacaaata ctacgcaacc tctgtgaaga gccgattcac catctccaga
      361 gacaattcca agagcatact atttcttcaa atgaacaact tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatattggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003017             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21287:12038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003017
VERSION     KCXD01003017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21287:12038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    82..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        82..457
     V_segment       82..381
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61499.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       386..402
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..457
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           99 a          140 c          116 g          104 t
ORIGIN      
        1 acatggggac tcctgtgccc caccatggac acgctttgct acacactcct gctactgacc
       61 gtcccgtcct gggtcttgtc ccaggtgacc ttgaaggagt ctggtcctgc gctggtgaaa
      121 cccacacaga ccctcacgct gacctgcacc ttctctgggt tctcaatcag tacttctgca
      181 acaggtgtgg gctggatccg tcagccccca gggaaggccc tggaatggct tgcaagcatt
      241 tattggaatg atactaaatt cttcagcact tcgctgaaga gcagactcac cgtctccaag
      301 gacacctcca aaacccaggt ggttctaaca atagccaaca tggaccctgt ggacacagcc
      361 acatattact gtgcacggat acagggtggt agttactact acggtggggg atacttcgag
      421 ttctggggcc agggcgccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003018             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14754:21329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003018
VERSION     KCXD01003018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14754:21329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..453
     V_segment       84..377
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61500.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       392..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT          100 a          123 c          136 g           96 t
ORIGIN      
        1 acatgggggg atcacagctc cttgccatgg actggacctg gaggatcctc ttcttggtgg
       61 cagcagcaac aggtgcccac tcccaggtgc agctggtgca gtcgggggct gaggtgaagc
      121 agccggggac atcagtggag gtctcctgca aggcttctgg ctacaccttc actagctatg
      181 gtatgaactg ggtgcgacag gcccagggac aacggcttga gtggatggga tggctcaaca
      241 ccgacactgg gaacccaacg tatgcccagg gcttcaaaga acgatttaca ttctccatgg
      301 acacctctat gaccacggca tatctgcata tcagcagcct aaagactgag gacacggccg
      361 tatacttctg tgcaagaagt ttgggctggc atgattataa tgacgtcgcc cttgacttct
      421 ggggccaggg agtcctggtc gccgtctcct cagcc
//
LOCUS       KCXD01003019             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17297:13598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003019
VERSION     KCXD01003019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17297:13598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61501.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       416..421
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          142 c          132 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcaggg
      121 gtcgggccca gggctggtga agccttcgga gaccctgtcc ctcacctgcg ctgtttctgg
      181 tgactccatc aacagtggct actactggag ttggatccgc caacccccag ggagggggct
      241 ggagtggatt gggtctatcg gtggtagtag tggcagcacc tactacaacc cctccctcaa
      301 gagtcgagtc accctttcaa aagacacgtc caggaaccag ttctccctga aactgagctc
      361 tgtgaccgcc gcagacacgg ccgtttatta ctgtgcgaga aaacttccag gtctccaact
      421 aaccggtttc gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003020             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15432:8691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003020
VERSION     KCXD01003020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15432:8691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61502.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          116 a          110 c          158 g          115 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttattatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaagt aagaaatact acggagactc tgtgaaggac cgattcagca tcgccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaaatggagg acacggcagt
      421 gtattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01003021             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12947:19374
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003021
VERSION     KCXD01003021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12947:19374"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61503.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       413..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          145 c          137 g           89 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccctca ccgaagtgtc cactcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtccacaga cacagcctac atggaactga
      361 gcagcctaag atctgaggac acggccgtgt attactgtgc gattggccct accggcaggt
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003022             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11542:5689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003022
VERSION     KCXD01003022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11542:5689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61504.1"
                     /translation="CAREYCTTRDCAGFLDSW"
     D_segment       408..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          110 a          136 c          140 g           99 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa gtctcctgca
      181 aggcttctgg attcaccttc gacaactatg gtatcaactg ggtgcgacag gcccctggac
      241 aggggcttga gtggatggga gtgatcatcc cccttattgg tataataaac tacgaagaga
      301 acgtccagga cagagtcacg atttccgcgg acacgtccac aaacacagcc tacatggagg
      361 tgcgcagcct gagatctgag gacacggcca tctattactg tgcgcgagaa tactgtacca
      421 ctagggattg cgccggattc cttgactcct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003023             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:8840:2946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003023
VERSION     KCXD01003023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:8840:2946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61505.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          112 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tattttcaaa tgaacaacct gaaattggaa gacacggccg
      421 tgtattactg tgcgagagat gtctatggca ggggacttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003024             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8024:4002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003024
VERSION     KCXD01003024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8024:4002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61506.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       443..455
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          110 c          158 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gctgggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagcaacgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tgatatcgtt
      301 tgatgaaagt aagaaatact atgcagactc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 gtattactgt gtgagagact cttatggaag tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003025             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17008:9720
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003025
VERSION     KCXD01003025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17008:9720"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61507.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..450
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          105 a          121 c          155 g          122 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cgctaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagttaa tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttac tactatatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt aacgctggtg
      301 gggataccac atactatgta gattccgtga agggcagatc caccatctcc agagagaacg
      361 ccaagaacac actgcatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgtgag agatcgacgt gttcagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003026             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14106:12505
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003026
VERSION     KCXD01003026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14106:12505"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61508.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           80 a          142 c          138 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg ttatggtggg agcacctact acaacccctc cctccagagt
      301 cgagtcacca tttcagccga cacgtccaag caccagttct ccctgatact gacctctgtg
      361 accgccgcgg acacggccct ctactactgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003027             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11636:17363
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003027
VERSION     KCXD01003027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11636:17363"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..279
     V_segment       8..218
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <210..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61509.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       222..234
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..279
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           70 a           68 c           82 g           61 t
ORIGIN      
        1 acatgggctt cagcagcctc ggcatgcact gggtccgccg ggctccaggg aaggggctgg
       61 agtgggtggc agttatctcg tctgatggaa gtcagaaata ttatgcagac tctatgaagg
      121 accgattcac catctccaga gacaatgcca agaacatgct gtatcttcaa atgaacaacc
      181 tgaaattgga ggacacggcc gtgtattact gtgcgagagg ggaatacagt aactctattg
      241 actactgggg ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003028             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24384:5094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003028
VERSION     KCXD01003028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24384:5094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61510.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       421..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           98 a          142 c          135 g          114 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa tgctctctga gagtcatgga cctcctgtgc
       61 aagaacatga agcacctgtg gttcttcctt ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc agctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 ctcacctgcg ctgtctctgg tgactccatc accagtagct actggaactg gatccgccag
      241 ccccccggga agggactgga gtgggttggc tatatttctg gtgcttatgg gagcaccagc
      301 tacaacccct ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccagttt
      361 tccctgaggc tgagttctgt gaccgccgcg gacaccgccg tgtattattg tgtgagatat
      421 gaggatgaat ccattaacta ccactttgac ttctggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01003029             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22329:3002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003029
VERSION     KCXD01003029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22329:3002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..493
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61511.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       438..444
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          110 a          113 c          153 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagtct ctggattcac cttcaggaat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgtttgatg
      301 gaattaagag ttattacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 caaagaacat gctaaatctt caaatgaacg acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag acgcccttgg aacgctgact actttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctccgcc
//
LOCUS       KCXD01003030             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20351:16461
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003030
VERSION     KCXD01003030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20351:16461"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61512.1"
                     /translation="CTAHYSGSYYVDYFAYW"
     D_segment       443..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          119 a          119 c          153 g          123 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcggc ctctggattc accttcagtg actatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg gttggctata ttagaagcga
      301 atatagaagt tacgcgacag aatacgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aggaacacgc tatatctgca aatgaacagc ctgaaaaaag aggacacggc
      421 cgtgtattat tgcaccgccc attatagtgg tagttattac gtagactact ttgcctactg
      481 gggccaggga gacctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003031             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:4438:14365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003031
VERSION     KCXD01003031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:4438:14365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61513.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       454..466
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          116 a          115 c          154 g          126 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtggctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcac tgatatcgta
      301 tgatggaagt aaggaatact atgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt attttcaact gcacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagtgg ggacatatga tagtggttat tatacctttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003032             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:21637:18614
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003032
VERSION     KCXD01003032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:21637:18614"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61514.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          118 a          145 c          133 g           97 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgac cctgcatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatctga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01003033             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20005:14411
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003033
VERSION     KCXD01003033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20005:14411"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61515.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       435..445
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          120 a          144 c          142 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctccccaac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg acttgttgat cctgtaaatg gtgaactaat
      301 acacgcagac aagttccagg gcagagtcac catgaccgaa gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgacatctga ggacacggcc atttattact gtgcgacagg
      421 gaggatcggt accagtggct ggtccaacct cttcaatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01003034             409 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20215:9592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003034
VERSION     KCXD01003034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 409)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 409)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20215:9592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    32..407
                     /note="immunoglobulin heavy chain variable region"
     V_region        32..407
     V_segment       32..323
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <317..>376
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61516.1"
                     /translation="CVRERFGGIGVIIFNWIDVW"
     D_segment       359..365
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       366..407
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        408..>409
                     /gene="IGHG"
BASE COUNT           86 a           97 c          131 g           95 t
ORIGIN      
        1 acatggggct cttttgaaag gtgtccagtg tgaggtgcac ctggtgcagt ctgggggcgg
       61 cctgacaaag cctggggggt ccctgagact ctcctgtgca gcctccggat tcaccttcag
      121 tgactactat atggactggg tccgccaggc tccagggaag gggctggagt gggtctcacg
      181 aatcggtcat gatggtggtt tcacatggta cgcagactcc gtgaagggca gatttaccat
      241 ttccagagag agtgccaaga acacactgtt tcttcaaatg gacagcctga gaagtgacga
      301 cacagccgta tattactgtg tgagagagcg gtttggggga attggggtaa taatcttcaa
      361 ctggatcgat gtctggggcc cgggagtcct ggtcaccgtc ccctcagcc
//
LOCUS       KCXD01003035             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14038:19098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003035
VERSION     KCXD01003035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14038:19098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61517.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          145 c          135 g           92 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gcaacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatt cactgggtgc gacaggcccc
      241 cggaaaagga cttgagtgga tgggaggcgt tgatcctgca tatggtgagt ttacacccgg
      301 agagaagttc cagggcagag tcaccatgac cgaagacacg tctataggca cagcctacat
      361 ggacctgagc agcctgaaat ttgaggacac ggccgtctat tactgtgcag ccggctatag
      421 cggcagctgg aaccactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01003036             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12042:9820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003036
VERSION     KCXD01003036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12042:9820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61518.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          114 a          112 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtgcgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaac taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaactacct gaaattggag gacacggcag
      421 tgtattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01003037             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17431:12050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003037
VERSION     KCXD01003037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17431:12050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61519.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          107 c          154 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag tttcagtaat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttatg tcatctgatg
      301 gaactaagaa attctacgca gactctgtga aggtccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca gcctgaaatc ggaggacacg gccgtatatt
      421 attgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtcacctc agcc
//
LOCUS       KCXD01003038             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18841:11402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003038
VERSION     KCXD01003038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18841:11402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61520.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          106 a          125 c          155 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttaatggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacgct
      301 ggtggggata ccacatacta tgtagactcc gtgaagggca gatccaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003039             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7821:17438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003039
VERSION     KCXD01003039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7821:17438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61521.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       436..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          103 a          128 c          159 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca ggtggtggag tctgggggcg gcttggcaaa
      181 gcccggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ccattagtgt
      301 tggtggtagt acatactacg cagactccgt gaggggccga ttcaccatct ccagagacaa
      361 ctcagagaac acgctctccc tgcacatgaa cagcctgaca gctgaggaca cggccgtgta
      421 ttactgtgcg aaaggggata cagctacagt ttattacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003040             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7185:14820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003040
VERSION     KCXD01003040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7185:14820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61522.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       413..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          118 a          140 c          132 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaaggag cctggggcct cagcgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atgcactggg tgctacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaaaca
      301 cacagagttc catgccagat tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttgagc agcctaagat ctgaggacac ggccctgtat tattgtgcag tcgggtatag
      421 cggccgatgg aacaactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01003041             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:16345:6801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003041
VERSION     KCXD01003041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:16345:6801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61523.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          115 a          119 c          158 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcc cttatatcgt
      301 ttgatggaac taagcaatac tacgcagact ctgtgaggga ccgattcacc atttcaagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tgcattactg tgcgagagtg agtggtcata cagagggtac agttgaatac tttgactact
      481 ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01003042             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15879:11774
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003042
VERSION     KCXD01003042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15879:11774"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61524.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          113 c          154 g          118 t
ORIGIN      
        1 acatgggggc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatggca
      241 ttcactgggt ccgccagact ccggggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaactaa gacatactac gcagactctg tgagggaccg attcaccatc tccagagaca
      361 attccaaaaa catggtgtat tttcaaatga acaacctgaa attggaggac acggccgtat
      421 attactgtgt gcgagatgtc aggggaacgg ggtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003043             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:3548:11874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003043
VERSION     KCXD01003043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:3548:11874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..397
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61525.1"
                     /translation="CASGRRQLDLDYW"
     D_segment       409..415
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           88 a          142 c          129 g          102 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagcta cacctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc tgtcacctgc gctgtctctg
      181 gtggctctat cagcacttac tactggaact ggatccgcca ggccccaggg aggggacttg
      241 actggattgg acatatctat ggtagtggtg atggcaccaa ctacaacccc tccctccaga
      301 gtcgagtcac cctgtcagtt gacacgtcca agaaccattt ctccctgacc ctgaggtctg
      361 tgaccgccgc ggacacggcc gtctattact gtgcgagcgg tcggcggcaa ctggaccttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003044             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16308:10995
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003044
VERSION     KCXD01003044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16308:10995"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..466
     V_segment       94..390
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <382..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61526.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       402..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           90 a          136 c          142 g          100 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcggga gtcgggccca
      121 gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 accagtagta attggtggag ctggatccgc cagtccccag ggaagggact ggaatggatt
      241 gggggtgtct atggtagtgg tgggaatacc gaatacaacc cctccctcaa gagtcgagtc
      301 accatttcaa aggacacgtc caagaaccag ttctccctga agctgaactc tgtgaccgcc
      361 gcggacaccg ccgtgtatta ctgtacgaga gaatggggcg ctatagcggc agttgggcct
      421 gtccttgcct cctggggcca gggtgtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003045             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15285:15880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003045
VERSION     KCXD01003045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15285:15880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61527.1"
                     /translation="CARYEEGGTAFEYW"
     D_segment       409..413
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           93 a          134 c          135 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggccctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggcgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 gactccatca ccagtagcta ctggagctgg atccgccggc ccccagggaa ggggctggag
      241 tggattggat atatctatgg tggtagcggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aatcagtttt tcctgaacct gagttctgtg
      361 aaggccgcgg acaccgccgt gtattattgt gccagatatg aagagggcgg aaccgccttt
      421 gagtactggg gccagggagt cctggtcacc gtctcgtcag cc
//
LOCUS       KCXD01003046             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15183:3349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003046
VERSION     KCXD01003046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15183:3349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61528.1"
                     /translation="CAAGYSGRWNQWYFDLW"
     D_segment       419..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          145 c          141 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcaa caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aaacctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattg tccattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggcgttgat cctgcatatg gtgaatttac
      301 acccggagag gagttccagg gcagagtcac catgaccgag gacacgtcta tagacacagc
      361 ctacatggag ctgagcagcc tgaactctga ggacacggcc gtctattact gtgcagccgg
      421 gtatagcggc cgctggaacc agtggtactt cgatctctgg ggccctggca ccccaatcac
      481 catctcgtca gcc
//
LOCUS       KCXD01003047             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22807:15726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003047
VERSION     KCXD01003047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22807:15726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..397
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61529.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       404..415
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           93 a          136 c          130 g          102 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagcta caattgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc tgtcacctgc gctgtctctg
      181 gtggctctat caacatttac tactggaatt ggatccgcca ggccccaggg aagggactgg
      241 actggattgg acatatctat ggtagcggtg gtagcaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagtg gacacgtcca agaaccactt ctccctgaac ctgaggtctg
      361 tgaccgccgc ggacacggcc gtatattact gtgcgagcgg tcggcggcag ctggactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003048             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9845:7801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003048
VERSION     KCXD01003048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9845:7801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61530.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          143 c          142 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggta aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtccacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggcttg gattcttggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003049             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:5943:13410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003049
VERSION     KCXD01003049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:5943:13410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61531.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       412..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          137 c          130 g          112 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg caactcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc ggcaatagct actggatctg gatccgccag cccccaggga aggggctgga
      241 gtggataggg tctatctatg gtagtactgg gagcaccttt tacgacccct ccctcaaggg
      301 tcgagtcacc gtttcaacag acacgtccaa gaacctattt tccctgactc tggactctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat agcgatactg atagttatta
      421 cttctttgac tactggggcc agggagtccg ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003050             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19530:9080
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003050
VERSION     KCXD01003050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19530:9080"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61532.1"
                     /translation="CARRGIAAGWSFDYW"
     D_segment       444..454
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          122 c          161 g          112 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtac agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttcctact
      241 acatgaactg ggtccgccag gctccaggaa aggggctgga gtggatctca ggtgttaaca
      301 gcggtgggga gagtacatac tatgcagact ccgtggaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagacctgag gacacggctg
      421 tctattactg tgcgagaaga gggatagcag ctggatggag ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003051             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21356:13733
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003051
VERSION     KCXD01003051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21356:13733"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61533.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       428..437
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          132 c          148 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc agcgatttat ccatgcactg ggtgcgacag
      241 gccccaggaa aagggcttga gtggatggga agtgttgatc ctgtatatgg tgaaataatt
      301 gtcgcagaga atttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatagagc tgagcagcct ggaatctgag gacacggccg tgtattactg tgcgaaaggg
      421 aggagtggtg gtgtctggcc gagctccttc gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003052             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11077:2965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003052
VERSION     KCXD01003052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11077:2965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61534.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          136 c          144 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga ccagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003053             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21156:12181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003053
VERSION     KCXD01003053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21156:12181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..508
     V_segment       133..425
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61535.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       428..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..508
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          104 a          126 c          156 g          124 t
ORIGIN      
        1 acatggggag acaggagcct tagccctgga ttccaagaac ttccactttg ggatcagctc
       61 tgaacacaga ggaccatgga gttggggctg agctgggttt tccttgttgc tattttaaaa
      121 ggtgtccagt ctgaggtgca gctggtggag tctgggggag gcttggtcca gcctgggggg
      181 tccctgagac tctcctgtgc agcctctgga ttcagctttg gcgatcatgg catgcactgg
      241 gtccgccagg ctccgggaaa gggactggag tgggtctcat ctatcagtaa tactggtaaa
      301 gccgtacact acgctgactc cgtgaagggc cgattcacca tctccagaga caacgccaag
      361 aactcgctgt ctctgcaaat gagcagcctg agagccgagg acacggccgt gtattactgt
      421 tctagcgatt actatagtgg tagttattac tattggggct acggcttgga ttcctggggc
      481 caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003054             374 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22184:13507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003054
VERSION     KCXD01003054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 374)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 374)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22184:13507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..371
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..371
     V_segment       8..298
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>341
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61536.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       305..320
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       323..371
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        372..>374
                     /gene="IGHG"
BASE COUNT           81 a           99 c          116 g           78 t
ORIGIN      
        1 acatgggggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
       61 aggtctcctg caaggtttcc ggatccacct tcaccgagtt atccatgcac tgggtgcgac
      121 aggcccctgg aaaagggctt cagtggatgg gaagtgttga tcctgcatat ggtgaaatga
      181 taaacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      241 cctacttgga gctgagcagc ctgtcatctg aggacacggc cgtgtatttc tgtgcgagtg
      301 gccctagcgg cagctggaac ggctggtact tcgatttctg gggccctggc accccaatca
      361 ccgtctcctc aacc
//
LOCUS       KCXD01003055             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14356:16454
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003055
VERSION     KCXD01003055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14356:16454"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..505
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61537.1"
                     /translation="CARVLYYDSGYSTNPYNRFDVW"
     D_segment       424..442
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          117 a          144 c          140 g          106 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacaccttc accatctatg ccatcacttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga ggaatcatcc ctcttgttgg tataacaaac
      301 gacgcacaga agttccaggg cagagtcacg atgaccgcgg acacgtccac aagcacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagagtt
      421 ttatactatg atagtggtta ttccacgaac ccctacaacc ggttcgatgt ctggggtccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003056             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17006:7764
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003056
VERSION     KCXD01003056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17006:7764"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61538.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          115 a          119 c          146 g          128 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgtttctat
      121 attaaaaggt gtccagtgtg tggagcatct ggtggagtct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc acctttagtg gctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctagaatgg gtatcaggta ttaacattgg
      301 cggtgaccca tactacccag actctgtgaa gggtcgattc accatctcca gagacaacgc
      361 caagaactcc ttgtatcttc aaatgaacaa cctgagacct gaggacactg ctgtgtatta
      421 ttgtgtgagg gggatggata actaccactt cagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003057             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16813:15993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003057
VERSION     KCXD01003057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16813:15993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61539.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       427..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          133 c          149 g          105 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgga gtccggggct gaggtgaaga agcctggggc ctcagcgaag ctctcctgca
      181 aggccgctgg atacattttc agtacctctg ccatcagttg gctgcgacag gcccctggac
      241 aagggcttga gtggatgggg gggatcatgc ctcttgttgg tagaacaaac tacgcacaga
      301 ggttccaggg cagagtcacg attaccgcgg acacgtccac aaggacagcc aacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattattg tgcgagcggt ggtttccagg
      421 atgagaacgg ttactatttt ccagactatt ttgacttttg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003058             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19032:20601
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003058
VERSION     KCXD01003058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19032:20601"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61540.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       443..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          109 c          158 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gcttcagtat ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat gtcgaatgat
      301 ggaagtaaga aatactacat agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaaa tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tattgcgcga gagacgattt tggcagcggc ttagggtact ggggccaggg agccctggtg
      481 accgtctcct cagcc
//
LOCUS       KCXD01003059             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12290:10965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003059
VERSION     KCXD01003059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12290:10965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..505
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61541.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       421..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          137 c          146 g          111 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctctgcca tcagttgggt gcgacaggcc
      241 cctggacaag gacttgggtg gatgggaggg atcatccctc ttgttggtat gacaaactac
      301 gaacagaagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      361 atggaactga gcagcctgag atctgaggac acggccgtct actattgtgc gacaggggta
      421 tattaccagg atgaatacgg ttatttttat gtcggcggtg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003060             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11481:9165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003060
VERSION     KCXD01003060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11481:9165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61542.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           99 a          140 c          142 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac agccacttcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc gtcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgtatatgg tgaaatggtg
      301 ttccagggcg gggtcaccat gaccgaggac acgtctacag acacagccta cttggagctg
      361 aacagcctga ggtctgaaga cacggccgtg tattactgtg cgattggccc tagcggcatc
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003061             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14787:16752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003061
VERSION     KCXD01003061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14787:16752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61543.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       433..439
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          120 a          141 c          141 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaaat gaagaagcct gggacctcag ttagggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt cgatcctgca caaggtgaaa taatacacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagccttcat
      361 ggagttgagc agcctgagat ctgaggacac ggccgtatat ttctgtgcga aaggggggtt
      421 cggaaccagc gtctggtcca acctcttcta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003062             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21083:12453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003062
VERSION     KCXD01003062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21083:12453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61544.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          121 c          144 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggc tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003063             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15272:8362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003063
VERSION     KCXD01003063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15272:8362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61545.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       431..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          123 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagtacata ctacgcagac tccgtgaggg gccgattcac catctccaga gacaactcag
      361 agaacacgct ctccctacaa atgaacagcc tgagagctga ggacacggcc gtgtattact
      421 gtgcgaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003064             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18554:15819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003064
VERSION     KCXD01003064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18554:15819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61546.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          142 c          131 g          100 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actaccaccc ctccctcaag
      301 agccgagcca ccatttcaaa agacacgtcc agcaatcaac tctccctgaa gctgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggcgt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003065             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9584:10597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003065
VERSION     KCXD01003065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9584:10597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..504
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61547.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       424..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>510
                     /gene="IGHG"
BASE COUNT          114 a          139 c          146 g          111 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca agacttctgg atacaccttc agcatctctg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttgg gtggatggga gggatcatcc ctcttgttgg tgtgacaaac
      301 tacgaacaga agttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc
      361 ttcatggaac tgagcagcct gagatctgag gacacggccg tctactattg tgcgacaggg
      421 gtatattacc aggatgaata cggttatttt tatgtcggcg gtgactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctccccagcc
//
LOCUS       KCXD01003066             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19275:9297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003066
VERSION     KCXD01003066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19275:9297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..485
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61548.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       402..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          101 a          135 c          138 g          113 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc gagaacatga agtatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agttgcagga
      121 gtcgggccca ggactgatga agccttcaga gaccctgtcc ctcagctgcg ctgtctctgg
      181 tggctccata agtggtaact ggtggagctg gatccgccag cccccaggga agggactgga
      241 ctggattgga cgtatctctg gtactagtgg ggacaccaat tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttc tccctgaagc tgaactctgt
      361 gaccgccgcg gacgcggccg tgtattattg tgcaagagcg gattacgagg atgattacgg
      421 ttatcattta ggatacaact ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003067             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5961:13285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003067
VERSION     KCXD01003067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5961:13285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61549.1"
                     /translation="CATADYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          149 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgccag ggtccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag tttcaaatac tacgcagact ctgtgaaggg ccgattcacc atttccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacactgccc
      421 tttattactg tgcgacagcc gactacggta acagccttga ctactggggt cagggagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01003068             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:9314:13047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003068
VERSION     KCXD01003068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:9314:13047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61550.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       439..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          115 c          152 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg gggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttctttca
      301 tctgatggaa gtaagaaata ctacgcaaac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatagt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatatgggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003069             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14282:6721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003069
VERSION     KCXD01003069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14282:6721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61551.1"
                     /translation="CARRGIAAGWSFDYW"
     D_segment       443..453
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          122 c          160 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtaca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttcctacta
      241 catgaactgg gtccgccagg ctccaggaaa ggggctggag tggatctcag gtgttaacag
      301 cggtggggag agtacatact atgcagactc cgtggagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gcgagaagag ggatagcagc tggatggagc tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003070             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6590:13181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003070
VERSION     KCXD01003070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6590:13181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61552.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          115 c          151 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcattc
      241 actgggtccg ccagactcca gggaaggggc tggagtgggt ggccgttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaccat ggtgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtatttt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gtgccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003071             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19334:20158
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003071
VERSION     KCXD01003071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19334:20158"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..483
     V_segment       126..413
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61553.1"
                     /translation="CTYRSSYYYGVESW"
     D_segment       416..420
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..483
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          100 a          140 c          136 g          109 t
ORIGIN      
        1 acatggggga gagtctccct caccgcacag ctgggatctc agtgcttcct tttctgtcct
       61 ccaccacgat ggggtcaact gccatcctca ccctcctact ggctgttctc caaggagtct
      121 gtgccgaggt gcagctggtg cagtctggag cagaggtgaa aaggcccggg gagtctctga
      181 agatctcctg taggacttct ggatacaagt tcagcagcta ctggatcaac tgggtgcgcc
      241 agatgcccgg aaaaggcctg gagtggatgg gggcgattga tcctagtgat tctgagacca
      301 gatacagacc gtccttccaa ggccaggtca ccatctcagc cgacaagtcc atcagtaccg
      361 cctacctgca gtggagcagc ctgaaggcct cggactccgc cacgtattat tgtacatacc
      421 ggtcttcata ttattacggt gtagagtcct ggggccaagg ggtcgtcgtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003072             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:9981:7137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003072
VERSION     KCXD01003072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:9981:7137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61554.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          147 c          141 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc gtatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caacttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgacatctg aggacacggc catctactac tgtgcgacag
      421 ggaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01003073             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15373:17893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003073
VERSION     KCXD01003073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15373:17893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61555.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       418..426
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          142 c          131 g          102 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggccga agtgaagaag cctggggcct cagtgagggt
      181 ctcctgcaag gtttccggac acaccttcag cgaattatcc attcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggagg ttttgctcct atatatggtg aaatcctaca
      301 cacagacaag ttccagggca gagtcacctt gaccgaggac acgtctacag acaccgccta
      361 tatggagttg agcagcctga gatctgagga cacggccgta tattactgtg tggcggctga
      421 tagtggttac cctttttact acttcgatat ctggggccct ggcaccccaa tcatcatctc
      481 ctcagcc
//
LOCUS       KCXD01003074             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12206:6339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003074
VERSION     KCXD01003074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12206:6339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61556.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          138 c          138 g           98 t
ORIGIN      
        1 acatggggga tccaacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa aggacttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatggtgt
      301 tccagggcag agtcaccatg accgaggata cgtctataga cacagcctac atggagttga
      361 gcagcctgag atctgaggac acggccgttt attactgcgc gattggccct agcggcaact
      421 ggaacggctg gtccttcgat atctgggggc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003075             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24912:11422
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003075
VERSION     KCXD01003075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24912:11422"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61557.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       402..415
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          133 c          141 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acttgcgttg tctctggcca
      181 ctccatcagc agtggctacc actggggctg gatccgtcag cccccaggga agggactgga
      241 ctatattggc tatatcagtg gtagtagtgg gagcacctac tacaagccct ccctcatgag
      301 tcgagtcatc atttcaagag acacgtcccg gaatgagttc tccctgaggc tgaggtctgt
      361 gactgtcgcg gacacggccg tgtattattg tgcgagacga gatagctgga acaacggggg
      421 gagccttgac tactggggcc agggattcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003076             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19201:15754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003076
VERSION     KCXD01003076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19201:15754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61558.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          126 c          156 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactacttt
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaccagt
      301 ggtggggcta acacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga ccacactgta tcttcacatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg taagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003077             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5899:16606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003077
VERSION     KCXD01003077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5899:16606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61559.1"
                     /translation="CATGRFGSSVWSTLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          143 c          149 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgagatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg acatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccaccctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003078             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11163:7489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003078
VERSION     KCXD01003078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11163:7489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61560.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          121 a          143 c          141 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctgggacc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt atatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003079             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8194:8989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003079
VERSION     KCXD01003079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8194:8989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61561.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       441..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          131 c          156 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatacactg ggtccgccag gctcccggga aggggctgga gtgggtctca gccattagta
      301 gtggtggtag cacatactac gcagactcca tgaagggccg agccaccatc tccagagaca
      361 actcaaagaa cacggtctcc ctgcaagtga acagcctgac ttctgaggac acggccgtgt
      421 tttactgtgc gagaggggag acagcttcag tttactacgc tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003080             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18798:19628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003080
VERSION     KCXD01003080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18798:19628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61562.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       422..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          142 c          133 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgaattatcg tttcactggg tgcgccaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcgtatggtg aaatgataca
      301 cacagagaac ttccagggca gaatcaccat gaccgaggac acgtctacag acacagccta
      361 catggagcta agcagcctga gatctgagga cacggccgtg tattactgtg cgatatcatc
      421 cagcggcagt tggctattct ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003081             415 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14021:16739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003081
VERSION     KCXD01003081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 415)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 415)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14021:16739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..413
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..413
     V_segment       56..348
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>382
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61563.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       354..359
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..413
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        414..>415
                     /gene="IGHG"
BASE COUNT           93 a           94 c          123 g          105 t
ORIGIN      
        1 acatgggggg ctgaactggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtaacta tggcatgcac tgggtccgcc aggctccagg
      181 gaagggcctg gagtgggtgg cagttatatc gtacgatgaa aataagaaat actacgcaga
      241 ctctctgaag gaccgattca ccatctccag agacaattcc aagaacatgc tttatcttca
      301 aatgaacaac ctgaaattgg aggacacggc cgtttattac tgtgcgagga ggccctggag
      361 tgcagatgct tttgatttct ggggccaagg actcagggtc accgtctctt cagcc
//
LOCUS       KCXD01003082             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10157:4079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003082
VERSION     KCXD01003082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10157:4079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61564.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       431..437
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          141 c          143 g           96 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccaactggt gcagtctggg gctgaaatga agaagcctgg ggcctcagtt agggtctcct
      181 gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga caggcccctg
      241 gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata atacacgcag
      301 agaaattcca gggcagagtc accatgaccg aggacacgtc cacagacaca gccttcatgg
      361 agttgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgaaa ggggggttcg
      421 gaaccagcgt ctggtccaac ctcttctacg gcttggattc ttggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003083             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18376:14130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003083
VERSION     KCXD01003083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18376:14130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..475
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61565.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       414..421
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>481
                     /gene="IGHG"
BASE COUNT           86 a          144 c          139 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agtaccaact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtgt atctttggtg gtggtatctt tggtggtgga agtaacacct actacagccc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagacccagc tctccctgaa
      361 actgacgtct gtaaccgccg cggacacggc cgtgtatttc tgtgcgagcg ctgatagcgg
      421 ttatcctccc tacttctttg acatctgggg ccagggagtc ctggtcaccg tctccccagc
      481 c
//
LOCUS       KCXD01003084             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13816:3168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003084
VERSION     KCXD01003084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13816:3168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61566.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          121 c          153 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggaa tctgggggcg gcttggtaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtcagg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tgatgggact ccctcaaatt atgcagactc cgtgaggggc aggttcacca tctccagaga
      361 gaacgccaag aatatactgt ttcttcaaat ggacagcctg aatcctgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat cattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003085             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11633:12986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003085
VERSION     KCXD01003085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11633:12986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61567.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       441..448
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          122 a          143 c          140 g          102 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtta agaagcctgg ggcctcagtg
      181 agggtctcct gccaggtttc cggatacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggatgtgttg atcctgtaaa tggtgaaata
      301 atacacgcag acaacttcca gggcagagtc accatgaccg aagacacgtc tatagacaca
      361 gcctacatgg aactgagcag cctgagatct gaggatacgg ccgtatatta ctgtgcgacc
      421 cacggaggct atagtgacat ctggaactcc ctgtactacg gtttggattc ctggggccaa
      481 ggggtcttcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003086             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13674:12107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003086
VERSION     KCXD01003086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13674:12107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61568.1"
                     /translation="CVRVHDYAMYYFDYW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          117 a          115 c          150 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctcttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaatataata tatcttcaaa tgaataccct gaaattggag gacacggccg
      421 tgtattactg tgtgagagtc catgactacg ccatgtacta ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003087             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20056:6317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003087
VERSION     KCXD01003087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20056:6317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61569.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          115 a          142 c          129 g           89 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaggct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatgggaaag tagactacac
      301 acagaagttc caagacagag tcaccatcac cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccacttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgactact ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01003088             418 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16143:5770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003088
VERSION     KCXD01003088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16143:5770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..416
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..416
     V_segment       56..349
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>385
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61570.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       350..354
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       370..416
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        417..>418
                     /gene="IGHG"
BASE COUNT           83 a          101 c          136 g           98 t
ORIGIN      
        1 acatggggtg ctgagctggg ttttccttgt tgctcttttg aaaggtgtcc agtgtgaggt
       61 gcagttggtg gagtctgggg gcggcttggc aaagcctggg gggtccctga gactctcctg
      121 cgcagcctct ggattcaact tcaattacta ctacatgaac tgggtccgcc aggctccagg
      181 gaaggggctg gagtggatct caggtattaa cagtggtggg gatagcacat actatgcgga
      241 ctccgtgaag ggcagattca ccatctccag agagaacgcc aagaacacac tgtctcttca
      301 aatggacagc ctgagagctg aggacacggc tgtctattac tgtgcgagag tggtgggtgg
      361 tgccgcagga tacttcgact tctggggcca gggcgccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003089             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20436:10540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003089
VERSION     KCXD01003089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20436:10540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..342
     V_segment       6..278
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61571.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       288..293
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..342
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           78 a           85 c          106 g           75 t
ORIGIN      
        1 acatgggggg cggcttggca aagcctgggg ggtccctgag actctcctgt gcagcctctg
       61 gattcacctt cagtaggcac tggatgaact gggtccgcca ggctccagga aaggggctag
      121 agtgggtctc aactattaat agtggtgggg ataacacata ttacgcagac tccgtgaagg
      181 gccgattcac catctccaga gacaactcaa agaacacgct cctcctgcaa atgaacagcc
      241 tgagagtgga ggacacggcc gtgtattact gtgttcaagg ggaaattttt ggagtgggtt
      301 tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003090             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20566:4297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003090
VERSION     KCXD01003090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20566:4297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..494
     V_segment       146..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61572.1"
                     /translation="CARADRGSSIDYW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagttgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtggggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaacctatg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga gtgggtggcg gttatatctt
      301 atgatgatga caagaaatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttttattg tgcgagagcg gatcgcggca gttcaattga ctactggggt cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01003091             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15269:20739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003091
VERSION     KCXD01003091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15269:20739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61573.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          115 a          143 c          130 g           92 t
ORIGIN      
        1 acatgggagc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg taaagtagac
      301 tacacacaga agttccgaga cagagtcacc atcaccgcgg acatgtcgac agagacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga ctactggggc cagggagccc tggtcaccgt ttcctcagcc
//
LOCUS       KCXD01003092             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:8793:4760
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003092
VERSION     KCXD01003092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:8793:4760"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    149..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        149..463
     V_segment       149..377
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61574.1"
                     /translation="CTAEITVEIVATPRSYDYW"
     D_segment       390..415
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          114 a          112 c          128 g          111 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagcctctg gattcacctt cagtgactat
      181 gccatgggct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      241 agcaactata accattacgc gacagaatac gccgcatcgg tgaaaggcag attcaccatc
      301 tccagagatg attcaaagaa cacgctatat ttgcaaatga gcagcctgaa aaccgaggac
      361 acggccgtgt attactgcac cgcagaaatc actgtagaga tagtggctac tcctcgttct
      421 tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003093             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18106:12444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003093
VERSION     KCXD01003093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18106:12444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61575.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       428..435
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          112 a          140 c          144 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atactccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtgtatgg tgaagaaata
      301 cacgcagaga atttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct gagacctgag gacacggccg tgtatttctg tgcggcgggc
      421 cttggggggt atttagtgct tactgaatac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01003094             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14622:16371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003094
VERSION     KCXD01003094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14622:16371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61576.1"
                     /translation="CARVWGRWELFEPGSEDFW"
     D_segment       412..419
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           85 a          139 c          144 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gcccccggga agggactgga
      241 gtggattggt tttatctatg gtactggtgg tagcacctac tacacaccct ccctcaagag
      301 tcgactcacc atttcagcgg acacgtccaa gaaccagttc tccctgcatc tgacctctgt
      361 aaccgccgcg gacacggccg tgtattactg tgcgagagtt tggggcaggt gggaactatt
      421 tgagcctggg tcagaggact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003095             318 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:8431:8680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003095
VERSION     KCXD01003095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 318)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 318)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:8431:8680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..316
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..316
     V_segment       5..255
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <247..>285
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61577.1"
                     /translation="CTRADRGSSIDFW"
     D_segment       263..269
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..316
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        317..>318
                     /gene="IGHG"
BASE COUNT           79 a           79 c           83 g           77 t
ORIGIN      
        1 acatgggggt ccctaagact ctcctgtgca gcctctggat tcaccttcag tacctatggc
       61 ttgcactggg tccgccaggg tccagggaag gggctggaat gggtggcggt tatatcttat
      121 gatgatgata agaaatacta cacagactct ttgaaggacc gattcaccat atccagagac
      181 aattccaaga acactcttta tcttcaaatg aacaacctga aattggagga cacggccgtg
      241 tattactgta cgagagcgga tcgcggcagt tcaattgact tctggggcca gggagtcctg
      301 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003096             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19006:12447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003096
VERSION     KCXD01003096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19006:12447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61578.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       449..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          114 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcgt
      301 ttgatgatag taagaaatac tactcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcttacggta gtggctggga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003097             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16126:12469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003097
VERSION     KCXD01003097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16126:12469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61579.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       417..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          117 a          137 c          139 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccagtctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct gggacctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccgtt cattgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtat tgatcctcta tatggtgaaa tgatacacac
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagata cagcctacat
      361 ggagctgagg agcctgagat ctgacgacac ggccgtgtat tactgtgcga ggtcggatag
      421 cggcagttgg aacggctggt acctcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01003098             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21684:12842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003098
VERSION     KCXD01003098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21684:12842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61580.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       441..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          116 a          111 c          158 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gaagcctctg gattcacctt cagttactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa gtaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacaggct atatcttcaa atgaacaacc tgaaattgga ggacacggca
      421 gtgtattact gtgcgagaga tgatagtggg gtgatcatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01003099             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14066:17393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003099
VERSION     KCXD01003099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14066:17393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..472
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61581.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       415..421
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           87 a          139 c          142 g          106 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gttcccagat gggtcctgtc ccaggtgcgg
      121 ctgcaggagt cgggcccagg acttgtgaag ccttcggaga ccctgtccct cacctgcgct
      181 gtctctggtg gctccttcag cggttactac tggggctgga tccgccggcc cccaggggag
      241 ggtctggagt ggattgggta tatcagtggg agtggtggga gttccgacta caagtcctcc
      301 ctcaagagtc gagtcaccat ttcaacagac acgtccaaga accacttctc cctgaagctg
      361 acctctgtga ccgccgcgga cacggccgtg tattactgtg cgagagtccg gggcgtaact
      421 atccactact ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003100             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18346:18233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003100
VERSION     KCXD01003100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18346:18233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61582.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       438..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          114 c          151 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggaacccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttatt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt acagcctctg gattcacctt cagtagttat
      241 ggcttgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tctgatgaaa gtaggaaata ctacgcagac tctctgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgaggga tgataatggg gtgcttatcg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003101             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:10179:8520
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003101
VERSION     KCXD01003101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:10179:8520"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61583.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       407..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           95 a          138 c          139 g          107 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gaggctctgt cagcagtagc acctggtgga actggatccg ccagccccca gggaaaggac
      241 tggaatggat tggctatatc agtggtgata gtggtaggaa ctcctacaac ccctccctca
      301 agagtcgaat caccatttca acagacacgt ccaagaacca gttctccctg aggctggggt
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag aggttcctat agtggcagtt
      421 attacttcaa ccggttcgat gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003102             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23788:12457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003102
VERSION     KCXD01003102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23788:12457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..516
     V_segment       153..444
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61584.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       454..471
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          103 a          157 c          136 g          122 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg gcgaggtgca gctggtgcag tctggagcag
      181 aggtgaaaag gcccggggaa tctctgagga tctcctgtaa gacttctgga tacagcttta
      241 ccacttactg gatcaattgg gtgcgccaga tgcccgggaa aggcctggag tggatgggaa
      301 tgatctatcc tagtgattct gatcccagat acagcccgtc cttccaaggc caggtcacca
      361 tctcagccga caagtccatc agcaccgcct acctgcagtg gagcagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagagctg gacgatacac ctacagttac ccctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003103             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19469:15329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003103
VERSION     KCXD01003103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19469:15329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..485
     V_segment       116..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61585.1"
                     /translation="CAREYCTSSACAGFFDSW"
     D_segment       410..421
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          107 a          141 c          138 g          101 t
ORIGIN      
        1 acatggggac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc tcatcaccat
       61 ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc agtcccaggt
      121 ccgcctggtg cagtccgggg ctgatgtgaa gaagcctggg gcctcagtga aggtttcctg
      181 cggggcttct ggattcaccc tcgactccta tggaatcaac tggatacgac aggcccctgg
      241 acaagggctt gagtggatgg gagtgaccat cccccttatt ggtatcacga actacgcaag
      301 gacgtctcag ggcagagtca caataaccgc gaacacgtcc acaaacacag cctacatgga
      361 gctgagcagc ctgaaatctg aggacacggc catctattac tgtgcgagag aatactgtac
      421 ttccagtgct tgcgccgggt tctttgattc ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003104             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:1969:13684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003104
VERSION     KCXD01003104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:1969:13684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61586.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       442..454
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          118 c          158 g          125 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgcttttt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggaatctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cctcagtaac tactggatgt
      241 attgggttcg ccaggcgcca gggaaggggc tggagtggat ctcaggtata aatagtgttg
      301 ggagtagtac atactatgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 cccagaacac actgtttctt caaatggaca gcctgagacc tgaggacacg gctgtctatt
      421 actgtgcgag agttccgggc ctagtggtgt ttaccggttc gcttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003105             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13997:3318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003105
VERSION     KCXD01003105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13997:3318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..400
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61587.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       406..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           93 a          142 c          132 g          110 t
ORIGIN      
        1 acatggggat gctgtctgag agtcagggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc aggtcccaga tgggtcctgt cccagccgca gctgcagctg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcgc ctgcgttgtc
      181 tctggtggct ccatcagcga ttactcctgg agctggatcc gccagccccc agggaaggga
      241 ctggagtgga ttgggaatat tgatgttcat cttgcgggcc ccaactacaa cccctccctc
      301 aagagtcgag tcgccatttc aaaagacacg tccaagaatc agttctccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtatat ttctgtgcga aacaatatag tggtagttat
      421 tactactccc actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003106             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16450:9666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003106
VERSION     KCXD01003106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16450:9666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61588.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          153 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003107             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:23725:12011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003107
VERSION     KCXD01003107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:23725:12011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..497
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61589.1"
                     /translation="CSRGSNYEDAYDYFSAFDSW"
     D_segment       423..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          138 c          139 g          108 t
ORIGIN      
        1 acatgggaca cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag gcttctggat acaccttcag catctatgcc atcaattggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gatcatccct cttgttggta taacaaacta
      301 cgtacagaag ttccagggca gagtcacgat taccgcggac acgtccacaa gcatagccta
      361 catggagctg agcggcctaa gatctgagga cacggccgtg tattactgtt cgagagggtc
      421 aaattacgag gatgcttacg attacttttc tgcctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003108             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20005:17150
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003108
VERSION     KCXD01003108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20005:17150"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..482
     V_segment       122..415
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61590.1"
                     /translation="CTRSPITAAGVFDFW"
     D_segment       426..435
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          119 a          136 c          127 g          102 t
ORIGIN      
        1 acatggggga ctcaacaact gcatccaacc tcaagagaag cccctgagag cacagtttct
       61 caccatggac ttgacctgga agatcctcct cttggtgaca gcagccacag gtgcccactc
      121 ccaggtgcag ctggtgcagt ctgggggtga gattaagcag cctggggcct caatgaagct
      181 ctcctgcaag gcttctggat ataccttcac tgactattac atacactggg tgagacaggc
      241 ccctggacaa ggccttgact gggtaggact gttctcccct tacaatgatt acaaagacta
      301 cgctcagaac ttccgggaca gagtcaccat aactgtggac atgtccacga gcacaggcta
      361 catggaactg agcagcctga gatctgagga cacagccgtg tattactgta cgagaagccc
      421 cataacagcg gctggagttt ttgacttctg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01003109             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7434:17323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003109
VERSION     KCXD01003109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7434:17323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61591.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          115 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttgaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01003110             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14748:15162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003110
VERSION     KCXD01003110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14748:15162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61592.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       421..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          141 c          147 g          107 t
ORIGIN      
        1 acagggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tctcaggtcc agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag
      181 ctctcctgta aggcttctgg atacagcttc agcatctatg tcatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc
      361 tacatggacc tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt
      421 tactgtactg gcaatggttg taaccttact ttcaaccggc tcgatgtctg gggcccggga
      481 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01003111             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24405:8000
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003111
VERSION     KCXD01003111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24405:8000"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61593.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       397..404
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           95 a          134 c          127 g          109 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcacct gcaggagtcg
      121 ggcccaggac tggtgaagtc ttcggagacc ctgtccctca cctgcggtgt ctctggtgac
      181 tccatcagca atagctactg gaactggatc cgccagcccc cagggaaggg actggagtgg
      241 attgggtata tctctggtgc ttatgggagc accagctaca atccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cagttttccc tgaggctgag ttctgtgacc
      361 gccgcggaca ccgccgtgta ttattgtgtg agatatgagg atgaatccat taactaccac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003112             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23609:4319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003112
VERSION     KCXD01003112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23609:4319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61594.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          101 a          125 c          162 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag tcactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg gattaacagt
      301 ggtggggata ctacatacca cgcagactcc gtgaagggca gattcaccat gtccagagag
      361 aacgccagga acacactgtc tcttcaaatg gacggcctga gagctgagga ctcggctgtc
      421 tattactgtg cgagagatcg acgtgtacag tcgttatctt ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003113             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19540:8899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003113
VERSION     KCXD01003113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19540:8899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..494
     V_segment       134..427
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61595.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       434..441
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          105 a          119 c          153 g          119 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc gatcagcact
       61 aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggtaa agcctggggg
      181 gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttatttct acatgagctg
      241 ggtccgtcag gctccaggga aggggctgga gtggatctca agtattgaca gtggtgggac
      301 taccacaaat tatgcagact ccgtgagggg cagcttcacc atctccagag agaacgccaa
      361 gaacagactg tatcttcaaa tggacagcct gagagctgag gacacggctg tctattattg
      421 tgcgagagcg cgcggggtga tcattacata ctttgactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01003114             434 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13232:3957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003114
VERSION     KCXD01003114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13232:3957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..432
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..432
     V_segment       78..371
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>401
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61596.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       375..387
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       391..432
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        433..>434
                     /gene="IGHG"
BASE COUNT           97 a           98 c          134 g          105 t
ORIGIN      
        1 acatgggcag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttactattt
       61 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      121 gggggtccct gagactctcc tgtgcagtct ctggattcac cttcagtagc tttggcatgc
      181 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtgaca tcctatgatg
      241 gaagttggaa gtactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      301 ccaagaacct gctatatctt caaatgaaca gcctgaaatt ggaggacacg gccacatact
      361 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      421 gcgtctcctc agcc
//
LOCUS       KCXD01003115             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16678:14932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003115
VERSION     KCXD01003115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16678:14932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61597.1"
                     /translation="CAAGHSGTWIHWYFDLW"
     D_segment       427..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          145 c          137 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagcttcac cgagttatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cgttgatcct gcatatggtg aatttacacc
      301 cggagagaag ttccagggca gagtaacaat gaccgaggac acgtctatag acacagccta
      361 catggaactg agcagcctga actctgagga cacggccgtc tattactgtg cagccgggca
      421 cagcggcacc tggatccact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003116             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5113:21914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003116
VERSION     KCXD01003116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5113:21914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..420
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <412..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61598.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       421..426
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          117 a          144 c          132 g           90 t
ORIGIN      
        1 acatgggggg agcatcacac aaccaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggctc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactccgagg tccagctggt acagtctggg gctgaggtga agaagcctgg ggcctccgtg
      181 aaaatctcct gccaggcttc tggatacacc ttaaccgacc actacctgca ctgggtgcga
      241 caggctcctg gaaaaggact tgagtggatg ggaggtgttc atcctgaata tgggaaagta
      301 gactacacac agaagttcca agacagagtc accatcaccg cggacatgtc gacagagaca
      361 gtctacatgg agctgagcag cctgagatct gaggacacgg ccacttatta ctgtgtgaca
      421 gtgggtccct accattactt tgactactgg ggccagggag ccctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01003117             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23737:9850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003117
VERSION     KCXD01003117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23737:9850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..331
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..331
     V_segment       7..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>300
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61599.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       270..276
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..331
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        332..>333
                     /gene="IGHG"
BASE COUNT           85 a           87 c           91 g           70 t
ORIGIN      
        1 acatgggggg cctcagtgaa ggtctcctgc aaggtttccg gatacatctt aaccgaatta
       61 tccatgcact gggtgcgaca ggcccctgga gaagggcttg agtggatggg aagtgttgat
      121 cctcaatatg gtgaaatgat agacgcagag aaattccagg gcagagtcac catgaccgag
      181 gacacgtcta cagacacagc ctacatggaa ctgagcagtc tgagatctga ggacacggcc
      241 gtatattact gtgcgacatc atccagcggc acctggctat actggtactt cgatatctgg
      301 ggccctggca ccccaatcac catctcctca gcc
//
LOCUS       KCXD01003118             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21336:21725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003118
VERSION     KCXD01003118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21336:21725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61600.1"
                     /translation="CATGRIGSSAWSSLFTGLDSW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          146 c          145 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgtaaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tgggaaaggg cctgagtgga tgggagttgt tgatcctgtc aatggtgaag aaatacacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tcgacagaca cagcctacat
      361 ggacttgacc agtctcagat ctgaggacac ggccatctat tactgtgcga cagggagaat
      421 cggtagcagc gcctggtcca gcctcttcac cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003119             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10457:11907
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003119
VERSION     KCXD01003119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10457:11907"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..489
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61601.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       438..444
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          113 a          143 c          138 g           97 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggagggtc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccaactggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctcccct
      181 gcaaggcttc tggatacacc ctcagcatct ctaccatcag ttgggtacga caggcccctg
      241 gacaagggct tgagtggatg ggggagatct tccctcttgt tggtaaaaca aaatacgcac
      301 agaagttcca cggcagagtc acgattaccg cggacacgtc cgcaagtaca gcctacatgg
      361 agctgagcgg cctgaaatct gaggacacgg ccgtctatta ctgtgcgaaa agaggtggcc
      421 acggtaccac caccacgttg tacttctttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01003120             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19110:11249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003120
VERSION     KCXD01003120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19110:11249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    147..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        147..495
     V_segment       147..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61602.1"
                     /translation="CARADRGSSIDYW"
     D_segment       446..452
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>501
                     /gene="IGHG"
BASE COUNT          114 a          116 c          152 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagaag actcaccatg aagtttgggc tgagttgggt tttccttgtt
      121 gcaattttaa gaggtgtcca gtgtggggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gtagcctctg gattcacctt cagaacctat
      241 ggcatgcact gggtccgcca ggccccaggg aaggggctgg agtgggtggc ggttatatca
      301 tatgatgatg acaagaaata ttacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacattct ttatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgttttatt gtgcgagagc ggatcgcggc agttcaattg actactgggg ccagggagtc
      481 ctggtcaccg tctccccagc c
//
LOCUS       KCXD01003121             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:8754:14513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003121
VERSION     KCXD01003121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:8754:14513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61603.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       435..445
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          103 a          123 c          159 g          113 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc gcagcctggg
      181 gggtccctga aactcccctg cgcagcctct ggattcagct tcagctactt ctacatgagc
      241 tgggtccgcc aggctccagg aaaggggctg gagtggatct cagggattga cagtggtggg
      301 ggtgacacat tctatgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaggacac tgtatcttca aatggacagc ctgagacctg aggacacggc tgtctattac
      421 tgtgcgaggt ctactgggag ctacagggga tactttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003122             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22337:14059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003122
VERSION     KCXD01003122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22337:14059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61604.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          109 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggtcca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggca agggactgga
      241 gtggattgga tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcgacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003123             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21644:2944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003123
VERSION     KCXD01003123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21644:2944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61605.1"
                     /translation="CSRRPWNADYFDFW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          111 a          120 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gacctgggtt ttccttgttg
      121 ctattttgag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgagg ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatatcgt
      301 atgatggaat taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acgattccaa gaacattgta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtattactg ctcgagacgc ccttggaacg ctgactactt tgacttctgg ggccagggag
      481 tcctggtcac cgccttctca gcc
//
LOCUS       KCXD01003124             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22728:7558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003124
VERSION     KCXD01003124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22728:7558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61606.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       423..432
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..496
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          109 a          149 c          138 g          102 t
ORIGIN      
        1 acatggggac atagcaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtacagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata caccttcaac atctatgcca tcaattgggt gcgacaggcc
      241 cctggacagg ggcttgagtg gatgggaggg atcatccctc ttgttgatat gacaaactac
      301 gcacagaggt tccagggcag agtcacgatt accgcggaca cgtccacagc cacagccttc
      361 ttggaactga gcagcctgag atctgacgac acggccattt attactgtgc gagagcccgg
      421 gcctacggta gcggctaccg ctcagactgg ttcttcgatg tctggggccc tggcacccca
      481 atcaccatct cctcagcc
//
LOCUS       KCXD01003125             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12405:20622
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003125
VERSION     KCXD01003125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12405:20622"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61607.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          118 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tgtattactg tgcgagagga gactacggta acagccttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01003126             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13312:5835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003126
VERSION     KCXD01003126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13312:5835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    65..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        65..428
     V_segment       65..353
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <350..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61608.1"
                     /translation="CVAADSGYPFYYFDVW"
     D_segment       361..369
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..428
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT          100 a          109 c          128 g           93 t
ORIGIN      
        1 acatgggggg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
       61 ctctgaggtc caactggtgc agtctggggc tgaagtaaag gggcctgggg cctcagtgaa
      121 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatacact gggtgcgaca
      181 ggcccctgga aaaggccttg agtggatggg aggttttggt cctgtatatg gtgaaataat
      241 agacacagag aagttccagg gcagagtcac tatgaccgag gacacgtcaa cagacacagc
      301 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtctattact gtgtggcagc
      361 tgatagtggt tacccatttt actacttcga tgtttggggc cctggaaccc caatcaccat
      421 ctcctcagcc
//
LOCUS       KCXD01003127             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16331:17518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003127
VERSION     KCXD01003127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16331:17518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61609.1"
                     /translation="CARVVGGAAGFFDFW"
     D_segment       443..451
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          115 c          154 g          124 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaaactggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcatg ttcagttatt actacatgaa
      241 ctgggtccgc caggctccag ggaagggcct ggaatggatc tcaggtatta acagtggtgg
      301 ggataccaca tactatgaag actccgtgaa gggcagattc accttgtcca gagacaacgc
      361 caggaacaca ctgtattttc aaatggacag cctgcgatct gaggacacgg ctgtctatta
      421 ctgtgcgaga gttgttgggg gggcagctgg tttctttgac ttctggggtc aaggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003128             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20183:7895
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003128
VERSION     KCXD01003128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20183:7895"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61610.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       447..457
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          110 a          130 c          151 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggtcc
      181 agcctggggg gtccctgaga ctctcctgta cagccactgg attcaccttt agtagttttg
      241 gcatgagctg ggtccgccag cctccaggga aggggctgga gtgggtctca tacattagta
      301 atagtggtag tagcacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct gacagctgag gacacggccg
      421 tgtatcactg tgcgaaacat cgtttcagca gctggtcgta tttccttgac ttctggggcc
      481 agggaatcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01003129             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23413:13031
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003129
VERSION     KCXD01003129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23413:13031"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..448
     V_segment       94..390
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61611.1"
                     /translation="CARWSAANFDSW"
     D_segment       395..401
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           86 a          134 c          135 g           95 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgggc aagaacatga agcatctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 aacagtggtt atggctggag ctgggtccgc cagcccccag ggaaggggct ggagtggatt
      241 gggtgtctct atgatagtag tgggaacacg tactacaacc cctccctcaa gagtcgcgtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga gcctgaggtc tatgaccgcc
      361 gcggacacgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga ctcctggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003130             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22520:15903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003130
VERSION     KCXD01003130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22520:15903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61612.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          113 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gtatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccat ctcctcagcc
//
LOCUS       KCXD01003131             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5106:19551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003131
VERSION     KCXD01003131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5106:19551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61613.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       444..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..513
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          119 a          122 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag tctccagggg aggggctgga atgggtggcg cttatatcgt
      301 atgatggaac taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagta agcggtataa ctgaaagttc cgttgaatac ttcgagttct
      481 ggggccaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01003132             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:10937:10942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003132
VERSION     KCXD01003132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:10937:10942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..450
     V_segment       81..374
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <366..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61614.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       375..386
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           96 a          124 c          132 g          100 t
ORIGIN      
        1 acatgggggc acagctcatc accatggact ggacctggag gctcctcttt gtggtggcag
       61 cagctgcagg tgtccagtcc caggtccgcc tggtgcagtc cggggctgag gtgaagaagc
      121 ctggggcctc agtgaaggtt tcctgcgggg cttctggatt caccctcgac acctatggta
      181 tcaactgggt gcgacaggcc cctggacaag ggcttgagtg gatgggagtg gtcatccccc
      241 ttattggtat cataaactac gcaaagaact ctcagggcag actcacaata accgcgaaca
      301 cgtccacaaa tacagcctat ttggaactga gcagtctgag atctgaggac acggccatct
      361 attactgtgc gagagaatac tgtacttcta gttcttgcgc cgggttcctt gactactggg
      421 gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003133             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17299:3756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003133
VERSION     KCXD01003133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17299:3756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61615.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       445..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          121 c          148 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgaa ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acttttggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      301 atggaaataa cctatactac gcagactctc tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catggtgtat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagattca tatggcagcg gctccgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003134             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12485:11815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003134
VERSION     KCXD01003134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12485:11815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61616.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       406..413
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           83 a          143 c          137 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttactc ctggagctgg atccgccagc ccccaggcaa gggtctggag
      241 tggattggac atgtcagtgg tagtagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag cgccagttct ccctgaggct gatttctgtg
      361 accgccgcgg acacggccgt ctatcattgt gcgagagtcc ggggcgtgac tatctattac
      421 tttgactact ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01003135             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14566:4726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003135
VERSION     KCXD01003135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14566:4726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61617.1"
                     /translation="CARGRGVIIVFFDYW"
     D_segment       442..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          104 a          124 c          155 g          121 t
ORIGIN      
        1 acatgggggc agctctgaga caggagcctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccaatg tgaggtgcag ctggtggagt ctgggggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcagttttgg taaatatgac
      241 atgcattggg tccgccaggc tccgggaaag ggcctggagt gggtctcatc cattagtaac
      301 gctggtgaaa ccgtcaaata cgctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga actcgctgtc tctacaaatg agcagcctga gagccgagga cacggccgtc
      421 tattactgtg ctagaggtcg aggggtgatt atcgtcttct ttgactactg gggccgggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003136             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20790:17551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003136
VERSION     KCXD01003136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20790:17551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..470
     V_segment       117..408
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61618.1"
                     /translation="CATADYGNSLDFW"
     D_segment       414..425
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>473
                     /gene="IGHG"
BASE COUNT          106 a          114 c          138 g          115 t
ORIGIN      
        1 acatggggaa gtccacagtg ttccattcgg tgatcagcac agaacacaga ggactcacca
       61 tgaagtttgg gctgagctgg gttttccttg ttgctatttt aagaggtgtc cagtgtgagg
      121 tgcagctggt ggagtcgggg ggaggcttga ttcagcctgg ggggtccctg agactctcct
      181 gtgcagcctc tggattcacc ttcagtagct ttggcatgca ctgggtccgc caggctccag
      241 ggaaggggct ggagtgggtg gcagttacat cgtctgatgg aagtatgaca tactacgcag
      301 actctatgaa ggaccgattc accatctcca gagacaattc caagaacatg ctatatcttc
      361 aagtgaacaa cctgaaattg gaggacactg ccgtttatta ctgtgcgaca gccgactacg
      421 gtaacagcct tgacttctgg ggccagggag tcctggtcac cgtctcctca acc
//
LOCUS       KCXD01003137             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8602:16975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003137
VERSION     KCXD01003137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8602:16975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61619.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          134 c          135 g          103 t
ORIGIN      
        1 acatgggaaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc aggtgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattgga tacatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003138             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14590:10902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003138
VERSION     KCXD01003138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14590:10902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61620.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       439..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          116 c          152 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tatttttaga ggtgtccagt gtgaagtcca actggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgcgac tctcctgtgc agcctctgga ttcaccttca ctacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatggaagt aagaaatatt acgcagactc tgtgaaggac cgattcacct tgtccagaga
      361 caataccaag aacatgctat atattcaaat gaacaacctg aaattggagg acacggccat
      421 gtattactgt gtgagagatg actacggtag cggcctcggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003139             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:8340:13264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003139
VERSION     KCXD01003139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:8340:13264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..343
     V_segment       8..276
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <268..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61621.1"
                     /translation="CARVAGVIIIYFDYW"
     D_segment       281..296
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..343
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           65 a          101 c          103 g           76 t
ORIGIN      
        1 acatgggcag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
       61 ggctccttcc gcggtcgcca ctggggctgg atccgccagc ccccagggaa gggactggag
      121 tggattggac gtatcgatgg tagtggtggg agcaccgact acaacccctc cctcaagagt
      181 cgagtcacca tttcaacaga cacgtccaag aatcagttct ccctgaacct gaggtctgtg
      241 accgccgcgg acacggccgt gtattactgt gcgagagtcg ctggggtgat aattatctac
      301 tttgattatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003140             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5497:16800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003140
VERSION     KCXD01003140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5497:16800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..457
     V_segment       79..370
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61622.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       389..399
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..457
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT          103 a          123 c          137 g           96 t
ORIGIN      
        1 acatggggac agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca
       61 gctacaggcg cccactctga ggtccacctg gtgcagtctg gggctgaggt gaagaagcct
      121 ggggcctcag tgaaggtctc ctgcaaggtt tccggataca ccgtcaccga attatccatg
      181 cactgggtgc gacaggcccc tggacaaggg cttgagtgga tgggacttgt tgatcctgta
      241 aatggtgaac taatacacgc agacaagttc cagggcagag tcaccatgac cgaagacacg
      301 tctacagaca cagcctacat ggagttgagc agcctgacat ctgaggacac ggccatttat
      361 tactgtgcga cagggaggat cggtaccagt ggctggtcca acctcttcaa tggtttggat
      421 tcctggggcc aaggggtcgt cgtcaccgtc tcttcagcc
//
LOCUS       KCXD01003141             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22833:8064
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003141
VERSION     KCXD01003141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22833:8064"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61623.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          106 a          125 c          159 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatactac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa cacgctctcc ctacaaatga acagcctgag agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003142             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19112:3302
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003142
VERSION     KCXD01003142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19112:3302"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61624.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       452..466
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          115 a          126 c          147 g          131 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattt ccagctgtct ccacttggtg
       61 atcagcactg aacacaggag actcgccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgactat
      241 gccctgagct gggtccgcca ggcttctggg aaaggactgg agtggattgg ctatattaga
      301 agccaatata acaatttcgc gacagaatac gccccatcgg tgaaaggcag attcaccatc
      361 tccagagatg attcaaagaa cacgctattt ctgcaaatga gtagcctgaa aaccgaggac
      421 acggccgtgt attactgcac cacccatttt ggtggtaatt attacttgga ctactttgtc
      481 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003143             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:27250:9164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003143
VERSION     KCXD01003143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:27250:9164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    70..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        70..439
     V_segment       70..363
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <355..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61625.1"
                     /translation="CAREYCTTADCAGFFDSW"
     D_segment       364..374
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           93 a          109 c          136 g          103 t
ORIGIN      
        1 acatggggga ccatggactg gacctggagg ctcctctttg tggtggcagc agctacaggt
       61 gtccagtccc aggtccagct ggtgcagtcc ggggctgagg tgaagaagcc tggggcctca
      121 gtgaaggttt cctgcaaggc ttctggattt accttcgaca actatggaat caactgggtg
      181 cggcaggccc ctggacaagg gcttgagtgg atgggagtgg tcatccccct tcttggtatt
      241 attaattatg cagagaactt ccagggcaga gtaacgatta acgcggacac gtccataagc
      301 acagccttca tggagttcag gagcctgaga tctgacgaca cggccattta tttctgtgcg
      361 agagaatact gtacaactgc ggattgcgcc gggttctttg actcctgggg ccagggagtc
      421 atggtcaccg tctcctcagc c
//
LOCUS       KCXD01003144             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24355:8652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003144
VERSION     KCXD01003144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24355:8652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61626.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       416..422
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          139 c          142 g           99 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctccagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccacc tggtgcagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaaag tttccggata caccttcacc gatttatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgatactg tatctgatgg agtgatatac
      301 gcagagaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgc gagaggtgtg
      421 acagcagacg tcttcggttt cctcgggctt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003145             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15344:10258
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003145
VERSION     KCXD01003145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15344:10258"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61627.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       435..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          106 a          127 c          158 g          126 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtctg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agctttggcg atcatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagtaatac
      301 tggtaaagcc gtacactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtata
      421 ttactgttgt agcgattact atagtggtag ttattactat tggggctacg gcttggattc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003146             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:16532:6013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003146
VERSION     KCXD01003146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:16532:6013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..488
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61628.1"
                     /translation="CAREYCTSDSCAGFLDSW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>495
                     /gene="IGHG"
BASE COUNT          117 a          138 c          137 g          103 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc acttggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccctt gacaattatg gaatcaactg ggtgcgacag
      241 gcccctggac acgggcttga gtggatggga gtgatcatcc cccttgtcgg aatagtgaac
      301 tacgtagaga acctccaggg cagaggcacg attaccgcgg acacgtcaac aaacacagtc
      361 tacatggaac tgaacagcct gagatctgac gacacggcca tctattactg tgcgagagaa
      421 tactgtactt ctgattcatg cgccggattc cttgactcct ggggccaggg agtcctggtc
      481 accgtctctc cagcc
//
LOCUS       KCXD01003147             417 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23758:4511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003147
VERSION     KCXD01003147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 417)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 417)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23758:4511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    61..415
                     /note="immunoglobulin heavy chain variable region"
     V_region        61..415
     V_segment       61..354
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>384
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61629.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       367..373
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       374..415
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        416..>417
                     /gene="IGHG"
BASE COUNT           95 a           91 c          126 g          105 t
ORIGIN      
        1 acatgggagt ttgggctgag ctgggttttc cttgttgctg ttttaagagg tgtccagtgt
       61 gaggtgcagc tggtggagtc tggaggagac ttggttcagc ctggggggtc cctgagactc
      121 tcctgtgcag cctctggatt caccttcagt aactatggca tacactgggt ccgccaggct
      181 ccagggaagg ggctggagtg ggtggcagtt atatcgtctg atgcaagtaa gacatactac
      241 gcaaactctg tgaaggaccg attcaccata ttaagagaca attccaagaa catgctatat
      301 cttcaaatga acaacctgaa attggaggac acggccgtct attactgtgc gagagacgat
      361 atgggaagtg gctttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003148             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:10672:8475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003148
VERSION     KCXD01003148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:10672:8475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61630.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       404..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           97 a          135 c          138 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tggctccttc agcggtttct attggagctg gatccgccag tccccaggga agggactgga
      241 gtggattggg tatatcagtg ctagtagtgg gagtaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa taaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag aaatactata gtggtagtta
      421 taaacacaac tggttcgatg tctggggccc gggagtccag gtcaccgtct cctcagcc
//
LOCUS       KCXD01003149             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13950:16795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003149
VERSION     KCXD01003149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13950:16795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61631.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          139 c          128 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcggc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc cccgggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gtactgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctagt caccgtctcc tcagcc
//
LOCUS       KCXD01003150             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17170:9217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003150
VERSION     KCXD01003150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17170:9217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61632.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          104 a          113 c          156 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggtttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtatct ctggcatgca
      241 ctgggtccgc caggctccag ggcaggggct ggattgggtg gcagttgaat cgtttgatgg
      301 aggtaagaaa tactacgctg actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgagcaa cctgaaattg gaggacacgg ccgtgtatta
      421 ctgtgtgaga gatgcctacg ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003151             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8221:10647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003151
VERSION     KCXD01003151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8221:10647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61633.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       417..423
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          139 c          141 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctccata agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca acagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatact gtatctgatg gagtgatata
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg cgagaggtgt
      421 gacagcagac gtcttcggtt tcctcgggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003152             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:7199:12089
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003152
VERSION     KCXD01003152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:7199:12089"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    29..408
                     /note="immunoglobulin heavy chain variable region"
     V_region        29..408
     V_segment       29..318
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <314..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61634.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       330..355
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..408
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        409..>412
                     /gene="IGHG"
BASE COUNT           97 a          110 c          121 g           84 t
ORIGIN      
        1 acatggggca gctacaggtg cccagtccca ggtccaactg gtgcagtccg gggctgaggt
       61 gaagaagcct ggggcctcag tgaagctctc ctgcaaggct tctgggttca cctttagcac
      121 cgaagccatc aattgggtgc gacaggcccc tggacaagga cttgactgga tgggaggggt
      181 catccctctt atgggtacaa caaactacgc acagaagttc cagggcagag tcacgtttac
      241 cgcggacacg tccataagca cagcctacat ggagctgagc agcctgagat ctgaggacac
      301 ggccgtgtat tattgtgcca aatccgtgaa ttacgaggaa gataacggtt actatatacc
      361 gacgcagttt gactactggg gccagggagt cctggtcacc gtctcctctg cc
//
LOCUS       KCXD01003153             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:7249:19644
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003153
VERSION     KCXD01003153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:7249:19644"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61635.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       444..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          117 a          108 c          155 g          118 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga actgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ttggtggagt ctggaggagg cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgca gcctctggat tcagtttcag tagttatggc
      241 atgcactggg tccgcctggc tccagggaag gggctggagt gggtggcagt tacatcgtct
      301 gatgaaagta agaaatacta cggagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acaaactata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tactactgtg ggagagatga taatggggtg attatcgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003154             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5189:16028
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003154
VERSION     KCXD01003154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5189:16028"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61636.1"
                     /translation="CARDPQWQLELLYFDSW"
     D_segment       407..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           95 a          145 c          131 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctcgttca gcaattccta ctggagctgg atccgccagc ccccagggaa ggggctggaa
      241 tggattggat atatcagtgg tgatagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gaactctgtg
      361 accaccgcgg acacggccgt gtattactgt gcgagagacc cccagtggca gctggagctc
      421 ctctactttg actcctggag ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003155             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17703:14254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003155
VERSION     KCXD01003155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17703:14254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61637.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       424..432
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          113 a          122 c          148 g          104 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg gccactctga
      121 ggtccagttg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca gtgtcaccga attatcgatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgta aaaggtgaag aaattcacgg
      301 agaggagttc caggacagag tcaccatgac cgaggacccg tctacagaca cagcctacat
      361 ggagttgagc aacctgagat ctgaggacac ggccgtgtat tattgtgcga gtgggtttag
      421 tgtctggtta tttaacgacg ttttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003156             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:10716:8722
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003156
VERSION     KCXD01003156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:10716:8722"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..271
     V_segment       8..194
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61638.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       198..211
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       225..271
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           68 a           63 c           86 g           56 t
ORIGIN      
        1 acatgggggg tccgccaggc tccagggaag gggctggagt gggtggcagc catatcgttt
       61 gatggaagta agaagaacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      121 aactccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      181 tactactgtt cgagggagtg gatacagtgg gcgcagttag tgagcggttt ggattcctgg
      241 ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003157             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18535:5993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003157
VERSION     KCXD01003157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18535:5993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..473
     V_segment       122..396
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61639.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       405..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          114 a          135 c          134 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cagagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctgatgcagt ccggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gttaccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa ggacttgggt ggatgggaag tgttgatcct gtatatggtg aaatgaaaga
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagtag
      361 cctgagatct gaggatacgg ccgtctatta ttgtgcagtc ggcaatagcg gcagctggat
      421 ctcctggtcc ttcgatgtct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01003158             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15568:17510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003158
VERSION     KCXD01003158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15568:17510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61640.1"
                     /translation="CARDAYGRGFDSW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          114 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcccggggg gtccctgaga ctctcctgtg cagcctctgg atacaccttc agtaattttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatatcgt
      301 atgatgaaga taagaattac cacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggcct
      421 tctattattg tgcgagagat gcttacggta gggggtttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003159             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11142:7299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003159
VERSION     KCXD01003159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11142:7299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61641.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          119 c          146 g          133 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagttcctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtttc cggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgta caagggggat agataactac cactttagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003160             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:11428:9692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003160
VERSION     KCXD01003160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:11428:9692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..491
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61642.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          117 a          113 c          147 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagggttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcaatacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgaatgatg
      301 aaactaaaaa atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatatctt caaatggaca acctgaaatt ggaggactcg gccgtgtatt
      421 actgtgttag agacgcattt ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01003161             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10852:19466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003161
VERSION     KCXD01003161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10852:19466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61643.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..433
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          111 a          141 c          141 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atactccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtgtatgg tgaagaaata
      301 cacgcagaga atttccagga cagattcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagc tgagcagcct gagacctgag gacacggccg tgtatttctg tgcggcgggc
      421 cttgggggat atttagttct tactgaatac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01003162             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:10755:13421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003162
VERSION     KCXD01003162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:10755:13421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61644.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       403..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           92 a          139 c          136 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccatcagc agtcactact ggagctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt atctatggtg gtgatgggta caccacctcc aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga ggtctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatccg cgttacgagg atgatcacgg
      421 ttactattct gtggaaattg actactgggg ccagggagtc ctggtcaccc tctcctcagc
      481 c
//
LOCUS       KCXD01003163             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11945:12573
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003163
VERSION     KCXD01003163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11945:12573"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61645.1"
                     /translation="CVRGVDNHHYTNTEFDFW"
     D_segment       443..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          123 c          147 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtag agtctggggg aggcttggta
      181 cagccggggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtacctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtggatatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc ggttcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gagctgagga cactgctgtg
      421 tattattgtg taagaggcgt agataaccac cactacacta atacggagtt tgacttctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003164             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15040:8801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003164
VERSION     KCXD01003164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15040:8801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..489
     V_segment       141..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61646.1"
                     /translation="CARADRGSSIDYW"
     D_segment       440..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>495
                     /gene="IGHG"
BASE COUNT          113 a          114 c          151 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaagactcac catgaagttt gggctgagtt gggttttcct tgttgcaatt
      121 ttaagaggtg tccagtgtgg ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca ccttcagaac ctatggcatg
      241 cactgggtcc gccaggcccc agggaagggg ctggagtggg tggcggttat atcatatgat
      301 gatgacaaga aatattacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca ttctttatct tcaaatgaac aacctgaaat tggaggacac ggccgtgttt
      421 tattgtgcga gagcggatcg cggcagttca attgactact ggggccaggg agtcctggtc
      481 accgtctccc cagcc
//
LOCUS       KCXD01003165             433 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14970:7474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003165
VERSION     KCXD01003165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 433)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 433)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14970:7474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    77..431
                     /note="immunoglobulin heavy chain variable region"
     V_region        77..431
     V_segment       77..370
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <362..>400
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61647.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       380..385
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..431
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        432..>433
                     /gene="IGHG"
BASE COUNT           97 a           93 c          133 g          110 t
ORIGIN      
        1 acatgggaga ggactcacca tgaagtttgg gctgagctgg gttttccttg tcgctatttt
       61 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      121 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagaaact ttggcatcca
      181 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gctgttatat cgtatgatga
      241 aaataacaga tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      301 caataatatg atatatcttc aaatgaacaa cctgaaattg ggggacacgg ccgtgtatta
      361 ttgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      421 cgtctcctca gcc
//
LOCUS       KCXD01003166             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15518:16893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003166
VERSION     KCXD01003166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15518:16893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61648.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          114 c          157 g          114 t
ORIGIN      
        1 acatgggggg aaaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg ttcagctggt ggagtctgga ggaggcttgg gtcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcagc ttcagtacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttaagt cgcatgatgg
      301 aactaagaaa tactacgcag actctgtgaa ggaccgattc accgtctcca gagacaattc
      361 caagaacatg ctatatcttg aaatgaacag cctgaaattg gaggacacgg ccgtgtatta
      421 ctgtgtgaga gatgcctacg ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003167             413 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10600:4034
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003167
VERSION     KCXD01003167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 413)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 413)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10600:4034"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    57..411
                     /note="immunoglobulin heavy chain variable region"
     V_region        57..411
     V_segment       57..350
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <342..>380
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61649.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       357..364
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..411
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        412..>413
                     /gene="IGHG"
BASE COUNT           88 a           91 c          127 g          107 t
ORIGIN      
        1 acatgggtgg gctgagctgg gttttccttg ttgctatttt aagaggtgtc cagtgtgagg
       61 tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg ggggtccctg agactctcct
      121 gtgcagcctc tggattcagc ttcagtaact ctggcattca ctgggtccgc caggctccag
      181 gggaggggct ggagtgggtg tcagttatat cgtatgatga aagtaagaca tactacgcag
      241 actctgtgaa ggaccgattc accatttcca gagacaattc caagaacatg gtacatcttc
      301 aaatgaacac cctgaatttg gaggacacgg ccgtatatta ctgtgtgaga gattcttacg
      361 gtagaggctt tgaccagtgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003168             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:23267:22119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003168
VERSION     KCXD01003168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:23267:22119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61650.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          121 a          138 c          136 g           93 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac atcttaaccg aattatccat acactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaagtg ttgatcctca atatggtgaa atgatagacg
      301 cagagaaagt ccaaggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagtctgaga tctgaggaca cggccgtgta ttactgtgcg acatcgtcca
      421 gcggcacctg gctatactgg tacttcgata tctggggccc tggcacccca atcaccatct
      481 cgtcagcc
//
LOCUS       KCXD01003169             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8147:15819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003169
VERSION     KCXD01003169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8147:15819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..469
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61651.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       409..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>472
                     /gene="IGHG"
BASE COUNT           96 a          140 c          128 g          108 t
ORIGIN      
        1 acatggggaa tggtctctga gagtcatggg cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accaatacct actggaactg gatccgccag cccccaggga aggggctgga
      241 atggattgga tttatctatg gtgctactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc atctcaacag acacgtccaa gaaccaattt tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat gatcagtggg atgattacct
      421 gtactacttt gactactggg gccagggagt cctggtcacc gtctcctcat cc
//
LOCUS       KCXD01003170             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18532:12710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003170
VERSION     KCXD01003170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18532:12710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..481
     V_segment       103..410
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61652.1"
                     /translation="CASADSGYPPYFFDFW"
     D_segment       417..426
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           83 a          143 c          141 g          116 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggag
      241 tggattgggt gtttctttgg tggtggtatc tttggtggtg gtactgacac ccagtacagc
      301 ccctccctca agagtcgagt caccctgtca gtagacgcgt ccaagaacca attctccctg
      361 caactgacgt ctgtgaccgc cgcggacacg gccgtgtatt tctgtgcgag cgctgatagt
      421 ggttatcccc cctacttctt tgacttctgg ggccagggag tcccggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01003171             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11122:15207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003171
VERSION     KCXD01003171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11122:15207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61653.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       293..298
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           76 a           83 c          113 g           78 t
ORIGIN      
        1 acatggggga gtctggagga ggcttgggtc agcctggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcagcttc agtacctctg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttaagtcgc atgatggaac taagaaatac tacgcagact
      181 ctgtgaagga ccgattcacc gtctccagag acaattccaa gaacatgcta tatcttgaaa
      241 tgaacagcct gaaattggag gacacggccg tgtattactg tgtgagagat gcctacgggg
      301 gcggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagct
//
LOCUS       KCXD01003172             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14725:7876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003172
VERSION     KCXD01003172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14725:7876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61654.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          111 a          120 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacgctat atcttgaaat ggacagcctg agaactgagg acacggctgt
      421 ctattattgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003173             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22179:10148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003173
VERSION     KCXD01003173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22179:10148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61655.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       442..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          122 c          154 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtggc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc gacctctgga ttcaccttca gtcgctttgg
      241 catgcactgg gtccgccagg ctccagggga ggggctggag tgggtggcag tcatatcgtc
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaac gacatgttat atcttcacat gaacgacctg aaattggagg acacggccgt
      421 gtattactgt gcgcgagacg tctacggtag cggacttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003174             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21961:13427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003174
VERSION     KCXD01003174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21961:13427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..486
     V_segment       117..410
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61656.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       425..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          113 a          142 c          137 g           96 t
ORIGIN      
        1 acatggggac ccaacaacaa cacccctcca cagaagcccc tggatcacag ctccttgcca
       61 tggactggac ctggaggatc ctcttcttgg tggcagcagc aacaggtgcc cactcccagg
      121 tgcagctggt gcagtcgggg gctgaggtga agcagccggg gacatcagtg aaggtctcct
      181 gcaaggcttc tggctacacc ttcactagct atggtatgaa ctgggtgcga caggcccagg
      241 gacaacggct tgagtggatg ggctggctca acaccgacac tgggaaccca acgtatgccc
      301 agggcttcaa agaacgattt acattctcca tggacacctc tatgaccacg gcatatctgc
      361 agatcaccag cctaaagact gaggacacgg ccgtatacta ctgtgcaaga agtttgggct
      421 ggcatgatta taatgacgtc gcccttgact tctggggcca gggagtcctg gtcgccgtct
      481 cctcagcc
//
LOCUS       KCXD01003175             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24953:16240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003175
VERSION     KCXD01003175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24953:16240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..343
     V_segment       7..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61657.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       265..285
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..343
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           83 a           91 c          100 g           71 t
ORIGIN      
        1 acatgggggg cctcagtgat ggtctcctgc caggtttccg gatacaccgt caccgaaatt
       61 tccatgcact gggtgcgaca ggcccctgga aaagggcttg agtggatggg aagtgttgct
      121 cctgaaaaaa atgagttaat acacgcagac aagttccagg acagagtcac catgaccgag
      181 gacacgtcta cagacacagc ctacatggag ctgagtggcc tgacatctga ggacacggcc
      241 gtgtattact gtgcgaccca cggagggtat agcgacatct ggaactccct atatcacggt
      301 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003176             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24216:17192
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003176
VERSION     KCXD01003176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24216:17192"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..496
     V_segment       145..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61658.1"
                     /translation="CANALTGGLDYW"
     D_segment       443..451
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          107 a          122 c          160 g          109 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcaccactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggca
      181 aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaggtac
      241 tggatgaact gggtccgcca ggctccagga aaggggctgg agtgggtctc agctattgca
      301 agtggtggag aaaacacata ctatgcagac tccgtgaagg gccgattcac cgtctccaga
      361 gacaactcaa agagcacagt ctccctgcaa atgaacagtc ttagaacgga ggacacggcc
      421 gtgtattact gtgcgaatgc gttaactggg gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003177             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:5462:9647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003177
VERSION     KCXD01003177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:5462:9647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61659.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       421..427
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          138 c          143 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagtccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggta cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaggtgttga tactgtatct gatggaatga
      301 tatacgcaga aaacttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgcgagag
      421 gtgtgacagc agacgtcttc ggtttcctcg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003178             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13560:8042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003178
VERSION     KCXD01003178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13560:8042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61660.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          110 a          118 c          156 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcaattatt actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atagtggtgg
      301 ggaaagcaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacacg ctatatcttg aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ttgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003179             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21268:5070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003179
VERSION     KCXD01003179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21268:5070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..488
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61661.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       430..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>495
                     /gene="IGHG"
BASE COUNT          113 a          139 c          141 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcctggtgg cggcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg gctgcgacag
      241 gcccctggaa aagggcttga gtggttggga tgtgttgatt ataaatatga tgaagaaata
      301 tacgcagaca atttccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtatttctg tgcggcgggc
      421 cttgggggat atttactgct tactgaatat ttccagttct ggggccaggg cgccctggtc
      481 accgtctctt ccgcc
//
LOCUS       KCXD01003180             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:10034:15187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003180
VERSION     KCXD01003180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:10034:15187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61662.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          112 c          155 g          117 t
ORIGIN      
        1 acatggggga ggtctgggag aggagcccag ccctggaagt ccacagtgtt ccaatcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaatt ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgtgagaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003181             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13588:12692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003181
VERSION     KCXD01003181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13588:12692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61663.1"
                     /translation="CATGYSGSWNHWYFDVW"
     D_segment       412..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          117 a          141 c          134 g           91 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgact tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg accctgcata tggtgaaatg
      301 aaacacgtag acagggtctc catgaccgag gacacgtcta cagacacagc ctacatggaa
      361 ctgagcagcc tgacatctga ggacacggcc gtgtattact gtgcaaccgg atatagtggc
      421 agctggaacc actggtactt cgatgtctgg ggccctggca ccccagtcac catctcctca
      481 gcc
//
LOCUS       KCXD01003182             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5672:12498
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003182
VERSION     KCXD01003182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5672:12498"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61664.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       415..419
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          146 c          135 g           99 t
ORIGIN      
        1 acatggggac aaaacaacca catccctcct ctaaagaagc ccctgggagc acagctcatc
       61 accatggact ggacctggag gctcctcttt gtggtggcag cagctgcagg tgtccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaaaatt
      181 tcctgcgggg cttctggatt caccttcgac acccatggta tcaactgggt gcgacaggcc
      241 cctggacaag gacttcagtg gatgggagtg atcatccccc ttattggtat caccaactac
      301 gcaaagaact ctcagggcag agtcacacta accgcggaca cgtccacaaa cacagcctac
      361 atggagctga acagcctgag atttgaggac acggccatct actactgtgc gagagaacgc
      421 tgcacttcta gtgtttgcgc cgggttcctt gactcctggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003183             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11758:13760
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003183
VERSION     KCXD01003183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11758:13760"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61665.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          123 a          140 c          136 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata ttccttcact cactacttca ttcactgggt gaggcaggcc
      241 cctggacaag gccttgagtg gataggactg atcacccctc acaatgatca caaaacctac
      301 gcacagaact tccagggcag agtcaccatg actacggaca cgtccacgag cacagtctac
      361 atggagctga acagcctgag atccgaggac acagccgtat attactgtgc gagagggggg
      421 gatatagaat actgtactgg tagtggttgt ggggaacttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003184             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25659:15270
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003184
VERSION     KCXD01003184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25659:15270"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61666.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       445..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          110 c          154 g          123 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttattgct
      121 attttaagag gtgtccagtg tgaggtgcac ctggtggagt ctgggggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcatgttcag taactatggc
      241 atccactggg tccgccaggc tccagggaag gggctggagt gggtgtcagt tatatcgtat
      301 gatgtaactg tgaaatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga atacggtata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattattgtg tgagagatgt caggggaacg gggtttgact tctggggcca gggagtcctg
      481 gtcaccgtct cgtcagcc
//
LOCUS       KCXD01003185             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:22158:12160
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003185
VERSION     KCXD01003185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:22158:12160"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61667.1"
                     /translation="CATGRLGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          138 c          151 g           99 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gagatgtcca tgcattgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gacagggagg
      421 ttggggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01003186             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15006:11481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003186
VERSION     KCXD01003186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15006:11481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61668.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          114 a          144 c          133 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgag gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tggatacggc
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggcca tttattactg tgcgactggc cctagcggca
      421 cctggaacgc ctggtacctc gaaatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01003187             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17621:8205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003187
VERSION     KCXD01003187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17621:8205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61669.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       426..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT           95 a          147 c          145 g          110 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggagcag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga gacacctcta cctactattg gatcagctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatggggg cgattgatcc tggtgattct gataccaaat
      301 atagtccgtc cttccaaggc caggtctcca tctcagccga caagtccatc agcaccgcct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtattactgt gcgaaagggg
      421 ggtggtgggg tgattatcca ccctcagact ggctcgatgt ctggggcccg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003188             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20346:12127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003188
VERSION     KCXD01003188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20346:12127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61670.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 accctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag ggtccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taggacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgata tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtccccgt ctcctcagcc
//
LOCUS       KCXD01003189             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:7063:7730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003189
VERSION     KCXD01003189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:7063:7730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..469
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61671.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       403..410
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           97 a          138 c          130 g          106 t
ORIGIN      
        1 acatggggga aacgctctct gagagtcatg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc ttctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct
      181 ggtgactcca tcagcagtag ctactggaac tggatccgcc agcccccagg gaagggactg
      241 gagtggattg ggtacatctc tggtgcttat gggagcacca gctacaaccc ctccctcaag
      301 agtcgaatca ccatttcaac agacacgtcc aagaaccagt tttccctggg gctgagttct
      361 gtgaccgccg cggacaccgc cgtgtattac tgtgtgagat atgaggatga atccattaat
      421 taccactttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003190             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24960:7954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003190
VERSION     KCXD01003190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24960:7954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61672.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          140 c          136 g           96 t
ORIGIN      
        1 acatgggggg atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003191             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21807:13747
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003191
VERSION     KCXD01003191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21807:13747"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61673.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          109 a          141 c          134 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactactg gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggtaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgcgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01003192             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11416:12132
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003192
VERSION     KCXD01003192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11416:12132"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61674.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          125 c          160 g          116 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatactac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003193             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12393:12579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003193
VERSION     KCXD01003193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12393:12579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61675.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          141 c          151 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgaaatg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gtgaaataat
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgagatctga ggacacggcc gtgtattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccagcct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003194             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13479:13490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003194
VERSION     KCXD01003194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13479:13490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61676.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       406..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          105 a          150 c          131 g           89 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagccc ggggcctcag tgaaggtctc
      181 ctgcaaggtc tccggaaaca ccttcaccga attgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcccgca tatggtgaaa tgacgttcca
      301 gggcagagtc atcatgaccg aggacacgtc tacagacaca gcctacatgg agctgaccag
      361 cctgacatct gacgacacgg ccgtctatta ctgtgcggtt ggccctagcg gcacttggaa
      421 ccactggccc ttcgatatct ggggccccgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01003195             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:5632:9471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003195
VERSION     KCXD01003195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:5632:9471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61677.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       308..319
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           86 a           81 c          111 g           84 t
ORIGIN      
        1 acatgggggt gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga
       61 gactctcctg tgcagcttct ggattcacct tcagtagtta tggcatgcac tgggtccgcc
      121 tggctccggg gaaggggctg gagtgggtgg cagttacatc gtctgatgaa agtaagaaat
      181 actacggaga ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatac
      241 tatatcttca aatgaacaac ctgaaattga aggacacggc cgtatactac tgtgggagag
      301 atgataatgg ggtgattatc gactactggg gccagggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01003196             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:27899:17756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003196
VERSION     KCXD01003196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:27899:17756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61678.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       264..276
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..318
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           77 a           72 c           94 g           77 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
       61 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      121 ttgatgaaag taagaaatac tacgtagatt ctgtgaagga ccgattcacc gtctccagag
      181 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      241 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      301 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003197             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12628:7834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003197
VERSION     KCXD01003197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12628:7834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61679.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       420..428
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          112 a          143 c          132 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggcc gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg acacaccttc agcgaattat ccattcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga ggttttgctc ctatatatgg tgaaatccta
      301 cacacagaca agttccaggg cagagtcacc ttgaccgagg acacgtctac agacaccgcc
      361 tatatggagt tgagcagcct gagatctgag gacacggccg tatattactg tgtggcggct
      421 gatagtggtt acccttttta ctacttcgat atctggggcc ctggcacccc aatcatcatc
      481 tcctcagcc
//
LOCUS       KCXD01003198             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:4440:13923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003198
VERSION     KCXD01003198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:4440:13923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61680.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       442..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          122 c          153 g          122 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggtaaat
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttatttctac
      241 atgagctggg tccgtcaggc tccagggaag gggctggagt ggatctcaag tattgacagt
      301 ggtgggacta ccacaaatta tgcagactcc gtgagggaca gcttcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagccgagga cacggctgtc
      421 tattattgtg cgagagcgcg cggggtgatt attacatact ttgactcctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003199             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9294:15598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003199
VERSION     KCXD01003199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9294:15598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61681.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          134 c          150 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcga
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc aatacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattagta
      301 gtggtggtac cacatactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgac aactgaggac acggccgtat
      421 attactgtgc gaagggaggt agcagctctt tctactggta cttcgatatc cggggccctg
      481 gcaccccagt caccatctcc tcagcc
//
LOCUS       KCXD01003200             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11072:7963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003200
VERSION     KCXD01003200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11072:7963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61682.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       438..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          113 c          156 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatatctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatatcgtc
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcaaaa aacatggttt atcttcaaat gaacaacctg aagttggagg acacggccgt
      421 gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003201             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21479:6410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003201
VERSION     KCXD01003201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21479:6410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61683.1"
                     /translation="CARDLNTALSYNSLDVW"
     D_segment       401..407
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..467
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          144 c          124 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc aataactact ggacctggat ccgccaatcc ccagggaagg gactggagtg
      241 gattggacgt atctctggtt atggtgactt caccgcctac aacccctccc tcgagagtcg
      301 agtctccatt tcaaaagact cgtccaagag ccaattctcc ctgaaactga actctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagatctc aatacagccc tttcgtacaa
      421 ctcattggat gtctggggcc ggggacttct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003202             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15917:17932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003202
VERSION     KCXD01003202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15917:17932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61684.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       442..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          112 a          115 c          153 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgca
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctctagaga
      361 caattccaag aatacggttt ttctgcaaat gaattccctg aaaatggagg acacggccgt
      421 gtattactgt gtgagagtcc atgactacgc tatgtactac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003203             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:4421:6909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003203
VERSION     KCXD01003203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:4421:6909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..500
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61685.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       422..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          117 a          141 c          145 g          101 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaacc ctggtgcctc agtgaagctc
      181 tcctgcaagg gttctggatt caccctcagc accgaggcca tcagttgggt gcgacaggcc
      241 cctggacaag gacctgactg gatgggaggg atcatccctc tcgtgggtgc aacaaactac
      301 gcacagaagt tccagggcag agtcaagttt accgcggaca cgtccataaa cacagcctac
      361 atggaactga gcggcctgag atctgaggac acggccgtgt attattgtgc gaaatccgtg
      421 aattacgagg aagataacgg ttactattta ccgacggggt ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01003204             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11240:9306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003204
VERSION     KCXD01003204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11240:9306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61686.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          115 a          144 c          130 g           92 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctacact gggtgcgaca
      241 ggctcctgga aaaggacctg agtggatggg aggtattcac cctgagtatg gtaaagtaga
      301 ctacacacag aagttccgag acagagtcac catcatcgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01003205             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21163:13020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003205
VERSION     KCXD01003205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21163:13020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..448
     V_segment       85..384
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61687.1"
                     /translation="CARRIRGGWPYFDFW"
     D_segment       394..398
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           97 a          138 c          114 g          101 t
ORIGIN      
        1 acatgggggt gactcctgtg ccccaccatg gacacgcttt gctccacgct cctgctgctg
       61 accgtcccgt cctgggtctt gtcccaggtg accttgaagg agtctggtcc tgcgctggtg
      121 aaacccacac agaccctcac gctgacctgc gccgtctctg ggttctcact caacaatatt
      181 ggtatggggg tgggctggat ccgtcagccc tcaggaaaaa ccctggagtg gcttgcacac
      241 atttactggg atgataacaa gctctacagc acatctctaa agaacagact caccatctcc
      301 agggacacct ccaaaaacct ggtacttctg acaatgacca acatggaccc tgcggacaca
      361 gccacatatt tctgtgcacg aagaattagg ggcggttggc cgtattttga cttctggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003206             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:6879:4048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003206
VERSION     KCXD01003206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:6879:4048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61688.1"
                     /translation="CARGYCSGSFCSSAFDYW"
     D_segment       427..437
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          118 a          129 c          146 g          103 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtcaggggc tgagatgaag aagcctgggg cctcagtgaa
      181 ggtctcttgc aaggtttccg gaaacacctt cagcgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aggtgttgaa cctggatatg gtgaaataat
      301 atatgcagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgagatctga ggatacggcc gtttattact gtgcgagggg
      421 atactgtagt ggtagtttct gttcgtcagc ctttgattac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01003207             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9703:3258
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003207
VERSION     KCXD01003207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9703:3258"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61689.1"
                     /translation="CVRGSYSGSYYFNRFDVW"
     D_segment       403..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           91 a          137 c          137 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctccatcagc agtagtacct ggtggaactg ggtccgccag cccccaggga aaggcctgga
      241 gtggatagga tatatcaatg gtgagagtgg tagcacctac tacaatccct ccctcgagag
      301 tcgaatcacc atttcaacag acacgtccac gaaccagttt tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgtgagaggt tcctatagtg gtagttatta
      421 cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003208             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16155:6925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003208
VERSION     KCXD01003208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16155:6925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61690.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          115 c          147 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01003209             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11737:11877
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003209
VERSION     KCXD01003209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11737:11877"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61691.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       437..442
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          114 c          156 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acttttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa gaaatactac gcagactctg tgaaggcccg attcaccgtc tccagagaca
      361 aatccaagaa catgttatat cttcaaatgg acaacctgaa attggaagac acggccgtct
      421 attactgcgc gagagatgtc tgggggaggg gatttgacta ttggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003210             367 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17289:3127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003210
VERSION     KCXD01003210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 367)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 367)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17289:3127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..363
     V_segment       7..286
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <281..>334
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61692.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       302..312
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..363
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>367
                     /gene="IGHG"
BASE COUNT           83 a           93 c          115 g           76 t
ORIGIN      
        1 acatggggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg
       61 caaggtttcc ggacacacct tcaccgaatt atccatgcac tgggtgcgac aggcccctgg
      121 aaaagggctt gagtggctgg gaggtgttga tcttgtatat gatgaaataa tacacgcaga
      181 gaagttccaa ggcagagtca ccatgaccga ggacacgtcg acagacacag cctacatgga
      241 actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcggcgg gccttggggg
      301 atatttactg ctcactgaat acctcgagtt ctggggccag ggcgccctgg tcaccgtctc
      361 ctccgcc
//
LOCUS       KCXD01003211             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19714:18836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003211
VERSION     KCXD01003211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19714:18836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61693.1"
                     /translation="CVKGDTAAVYYGLDFW"
     D_segment       431..440
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          102 a          127 c          155 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactggc agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcagagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctgttc
      241 actgggtccg ccaggctcca gaaaaggggc tggagtgggt ctcagctgtt agtaccggtg
      301 gtaccacata ctactcagac tccgtgaagg gccgattcac catctccaga gacaactcaa
      361 agaacacgtt ctcccttcaa atgagcagcc tgagagctga ggacacggcc gtgtattact
      421 gtgtgaaggg ggatacagct gcagtctact acggtttgga tttctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003212             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4902:8397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003212
VERSION     KCXD01003212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4902:8397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..473
     V_segment       110..405
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61694.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       411..425
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           97 a          137 c          130 g          111 t
ORIGIN      
        1 acatggggat gggaaatgtt ctctgagagt cacggacctc ctgtgcaaga acatgaagca
       61 cctgtggttc ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct
      121 gcaggagtcg ggcccaggac tggtgaagcc ttcggagacc ctgtccctca catgcgctgt
      181 ctctggtgac tctatcagca gtagtcactg gtggagctgg atccgccagc ccccagggaa
      241 aggcctggag tggattggct atatcagtgg tagtggtgat aacacctact acaacccctc
      301 cctcaagaat cgagtcacct tttcaacagt cacgtccaag aaccagttct cccttaagct
      361 gagctctgtg accgccgcgg acacggccat gtattactgt tcgagggtgc gtggatacaa
      421 ctacatttta tttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003213             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21173:18922
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003213
VERSION     KCXD01003213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21173:18922"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..469
     V_segment       100..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61695.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       400..411
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           95 a          138 c          135 g          103 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc tttggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagca gtaactactg gagctggatc cgccagtccc caggaaaggg actggagtgg
      241 attggacgta tttctgggag tggtgggagc accgtctaca acccctccct caagagtcga
      301 gtcacctttt caacagacac gtccaagaac gagatctccc tgaaagtgac ctctgtgacc
      361 gccgcggaca cggccgtata ttattgtgcg acagccggat atagcagcag cgaaagcttc
      421 tacggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01003214             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17337:14310
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003214
VERSION     KCXD01003214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17337:14310"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61696.1"
                     /translation="CARSPSGNWLYWFFDFW"
     D_segment       422..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          147 c          129 g          100 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattttc catccactgg ctacgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgtttttggt gaaataattc
      301 acgcagagat attccagaac agagtcaccc tgaccgagga cacgtctaca gacacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattactgt gcgcgatcac
      421 ccagcggcaa ctggctatac tggttcttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01003215             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12131:11960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003215
VERSION     KCXD01003215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12131:11960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61697.1"
                     /translation="CATSSTGTWLYWYFDVW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          143 c          139 g           94 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccga cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaggt acaggcgccc
      121 actctgaggt ccagctggtg cagtcggggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctgtgtat ggtgaaataa
      301 taaattcaga gaagttccag ggcagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtattac tgcgcgacat
      421 catccaccgg cacctggcta tactggtact tcgatgtctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01003216             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9308:2830
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003216
VERSION     KCXD01003216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9308:2830"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61698.1"
                     /translation="CVRDEYGSGLGFW"
     D_segment       447..456
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatggaag taaaaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gagtacggta gtggtttagg cttctggggc cagggagacc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003217             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:25296:16948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003217
VERSION     KCXD01003217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:25296:16948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..511
     V_segment       136..427
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61699.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       447..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          111 a          121 c          159 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggta tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcacctggtg cagtctgggg gcggcttgac aaagcctggg
      181 gggtccctga gactctcctg tgcggcctcc ggattcacct tcagtgacta ctatatggac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtct cacgaatcag tcatgatggt
      301 gatagcacat ggtacgcaga ctccgtgaag ggcagattta ccatttccag agagaatgcc
      361 aagaacacac tgtttcttca aatggacagc ctgagaagtg aggacacagc cgtatattac
      421 tgtgcgagag agcgttttgg gggaattggg gtgattatct tcaactggat cgatgtctgg
      481 ggcccgggag tcctggtcac cgtcccctca gcc
//
LOCUS       KCXD01003218             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8327:20002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003218
VERSION     KCXD01003218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8327:20002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61700.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       442..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          112 c          161 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgttatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcagccc
      181 ggggggtcac tgagactgtc ctgtgcagcc tctggattca ccttcagtag ctctggcatg
      241 cactgggtcc gccaggctcc agggaaggga ctggagtggg aggcacttat atctaatgat
      301 ggaagtaaga aatattacgc agactccgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctgtatct tcaaatgaac aacctgaaat tggatgacac ggccgtgtat
      421 tactgtgcgc gagttggaga gggtagtggt ggtgcggagg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003219             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21307:6719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003219
VERSION     KCXD01003219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21307:6719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61701.1"
                     /translation="CARDVYGGGLDYW"
     D_segment       439..444
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          115 c          151 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtccacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggtgggtccc tgagactctc ctgttcagcc tcaggattca ccttcaacac ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggaatggg tggcagttat atcgtctgat
      301 ggaagtaaga aatactacgc agactctttg agagaccgat tcaccatatc cagagacagc
      361 tccaagaaca tggtatatct tctactgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttctgtgcga gagatgttta tggtgggggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003220             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9831:18083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003220
VERSION     KCXD01003220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9831:18083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61702.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 gcccgggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttttgtcgt
      301 ctgatggagg ttacaaatac cacgcagact ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003221             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11742:2995
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003221
VERSION     KCXD01003221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11742:2995"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61703.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          115 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatagcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaactaagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01003222             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12679:14761
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003222
VERSION     KCXD01003222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12679:14761"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61704.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          152 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatggaaa taagaaatac tacgcagact ctgtgaagga ccgattcatc atctccagag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003223             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:25751:11187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003223
VERSION     KCXD01003223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:25751:11187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..472
     V_segment       100..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61705.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       402..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          138 c          137 g          106 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca catgcgctgt ctctggaggc
      181 tctgtcagca gtagcacctg gtggaactgg atccgccagc ccccagggaa aggactggaa
      241 tggattggct atatcagtgg tgatagtggt aggaactcct acaacccctc cctcaagagt
      301 cgaatcacca tttcaacaga cacgtccaag aaccagttct ccctgaggct ggggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagaggtt cctatagtgg cagttattac
      421 ttcaaccggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003224             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16245:16391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003224
VERSION     KCXD01003224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16245:16391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..473
     V_segment       109..402
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61706.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       414..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>477
                     /gene="IGHG"
BASE COUNT           91 a          141 c          138 g          107 t
ORIGIN      
        1 acatgggggg ggaaatggtc tctgagagtc atgggcctcc tgtgcaagaa catggagcac
       61 ctgtggttct tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcagctg
      121 caggagtcgg gcccaggact ggtgaggcct tcggagaccc tgtccctcac ctgcgctgtc
      181 tctggtgact ccatcaccag tacctactgg aactggatcc gccagccccc agggaagggg
      241 ctggagtgga ttggatttat ctatggtgct actgggagca ccggctacaa cccctccctc
      301 aagagtcgag tcaccatctc aacagacacg tccaagaacc agttttccct gaagctgagc
      361 tctgtgaccg ccgcggacac cgccgtgtat tactgtgcga gatatgatca gtgggatgat
      421 tacctgtact actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcgtcc
//
LOCUS       KCXD01003225             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:21444:8986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003225
VERSION     KCXD01003225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:21444:8986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..330
     V_segment       6..257
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61707.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       268..280
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           73 a           86 c           98 g           75 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccctc agtaactact
       61 ggatgtattg ggttcgccag gcaccaggga aggggctgga gtggatctca ggcataaata
      121 gtgttgggag tagtacatac catgcagact ccgagaaggg cagattcacc atctccagag
      181 agaacgccca gaacacactg tttcttcaaa tggacagcct gagacctgag gacacggctg
      241 tctattactg tgcgagagtt ccgggcctag tggtgtttac cggttcgctt gactactggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003226             394 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14253:11494
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003226
VERSION     KCXD01003226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 394)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 394)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14253:11494"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    222..392
                     /note="immunoglobulin heavy chain variable region"
     V_region        222..392
     V_segment       222..331
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <323..>361
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61708.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       335..347
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       351..392
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        393..>394
                     /gene="IGHG"
BASE COUNT           91 a           95 c          111 g           97 t
ORIGIN      
        1 acatgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc aactctgtga aggaccgatt
      241 caccatctcc agagacaatt ccaagaacat gctatatctt caaatgaaca acctgaaatt
      301 ggaggacacg gccctgtatt actgtgcgag aggggaatac agtaactcta ttgacttctg
      361 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003227             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22317:16942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003227
VERSION     KCXD01003227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22317:16942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61709.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       412..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          113 a          135 c          133 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacttg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggcgca gtctggggct gacgtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccttc accgaattat ccctgcactg ggtgcgacag
      241 ggccctggaa aaggacttga gtggatggga ggttttgctc ctatatatgg tgaattaatc
      301 catgaaaggt tccagggaag agtcagtttg accgaggaca cgtccacaga cacagcctat
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc ggcagctgat
      421 agtggttacc cattttacta cttcgatatc tggggccctg gcaccccaat caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01003228             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:23127:4090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003228
VERSION     KCXD01003228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:23127:4090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..363
     V_segment       6..276
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61710.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       292..303
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       317..363
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           81 a           96 c          114 g           74 t
ORIGIN      
        1 acatgggggc tgaggtgaag cagcctgggg cctcagtgaa ggtctcctgt caggtttccg
       61 gatacaccgt caccgaatta tccatgcact gggtgcgaca ggcccctggg aaagggcttg
      121 agtggatggg agttgttgat cctgtcaatg gtgaagaaat tcacgcagag aacttccagg
      181 gcagagtcac catgaccgag gacacgtcga cagacacagc ctacatggac ttgaccagtc
      241 tcagatctga ggacacggcc atctattact gtgcgacagg gaggatcggt ggcagcggct
      301 ggtccaacct cttcaccggt ttggaatcct ggggccaagg ggtcgtcgtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01003229             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14309:4593
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003229
VERSION     KCXD01003229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14309:4593"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61711.1"
                     /translation="CATSSSGTWLYWYFDLW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          143 c          131 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgccgagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagtctga gatccgagga cacggccgta tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tctctggggc cctggctccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003230             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17822:5226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003230
VERSION     KCXD01003230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17822:5226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..316
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..316
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61712.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       260..266
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..316
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        317..>319
                     /gene="IGHG"
BASE COUNT           78 a           78 c           85 g           78 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaattttgg
       61 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      121 tgatggaagt aacaaatact acgccaactc tgtgaagagc cgattcacca tctccagaga
      181 caattccaag agcatactat atcttcaaat gaacaacttg aaattggagg acacggccgt
      241 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      301 ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01003231             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17967:4654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003231
VERSION     KCXD01003231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17967:4654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61713.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          102 a          126 c          158 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 tcatgagttg ggtccgccag gctccaggga aggggctgga gtggatctca ggtatttcca
      301 gtggtgggga tagcacatac tctgcagact ccgtgaaggg cagattcacc atttccagag
      361 agaacgccaa gaccacactg tatcttcaca tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcaagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003232             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22458:7070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003232
VERSION     KCXD01003232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22458:7070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61714.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          114 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagagatgt ccagtgtgag gtgcacctgg tggaatctgg aggaggttcg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcattc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003233             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:28216:15051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003233
VERSION     KCXD01003233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:28216:15051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61715.1"
                     /translation="CTRSPITAAGVFDFW"
     D_segment       425..434
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          119 a          136 c          125 g          103 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtgcagtc tgggggtgag attaagcagc ctggggcctc aattaagctc
      181 tcctgcaagg cttctggata taccttcact gactattaca tacactgggt gagacaggcc
      241 cctggacaag gccttgactg ggtaggactg ttctcccctt acaatgatta caaagactac
      301 gctcagaact tccgggacag agtcaccata actgtggaca tgtccacgag cacaggctac
      361 atggaactga gcagcctgag atctgaggac acagccgtgt attactgtac gagaagcccc
      421 ataacagcgg ctggagtttt tgacttctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01003234             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:28607:12202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003234
VERSION     KCXD01003234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:28607:12202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61716.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          144 c          134 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggtcca actgatacag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acgcagaaag attccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagtctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcac ctggctatat tggtacttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01003235             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22894:7755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003235
VERSION     KCXD01003235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22894:7755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61717.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          124 c          150 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cggcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtgtct ggttatttaa cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003236             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14078:4956
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003236
VERSION     KCXD01003236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14078:4956"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61718.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          115 a          121 c          145 g          129 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggtggagt ctgggggagg cttggtacag
      181 cctggggcgt ccctgagact ctcctgtgca gcctctgaat tcaccttcag tggctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctagaat gggtatcagg tattaacatt
      301 ggcggtgacc catactaccc agactctgtg aagggtcgat tcaccatctc cagagacaac
      361 gccaagaact ccttgtatct tcaaatgaac aacctgagac ctgaggacac tgctgtgtat
      421 tattgtgtga gggggatgga taactaccac ttcagtaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003237             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9330:11217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003237
VERSION     KCXD01003237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9330:11217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..493
     V_segment       138..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61719.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       434..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          111 c          155 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtata tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtcagttata tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 caaaaaaaca tggtttatct tcaaatgaac aacctgaagt tggaggacac ggccgtgtat
      421 ttctgtgtga gagatgcctt cgggggcggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003238             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15356:9828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003238
VERSION     KCXD01003238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15356:9828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61720.1"
                     /translation="CASGGYEDDSGFYFPDFFDSW"
     D_segment       421..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          135 c          146 g          115 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgtccagtc
      121 ccaggtccag ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag gctgctggat acatctttag tatctctgcc atcagttggg tgcgacaggc
      241 ccctggacag ggacttgagt ggatgggagg gatcatccct cttgttggtg taacaaataa
      301 cgcacggaag ttccagggca gagtcacgat taccgcggac acgtccacaa gcacagcctt
      361 catggatctg agcagcctga gatctgagga cacggccgtc tattattgtg cgagcggtgg
      421 ttacgaggat gattccggtt tttattttcc agacttcttt gactcctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003239             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11307:11014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003239
VERSION     KCXD01003239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11307:11014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61721.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          111 c          153 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tatgatgtaa ctaagaaata ttacgcagac gctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaataacc tgaaaatgga ggacacggcc
      421 gtgtattact gtgggagaga tgataatggg gtgcttatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003240             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17263:7638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003240
VERSION     KCXD01003240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17263:7638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61722.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          112 c          155 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt cctgtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctc
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgtctgatg
      301 gaagtagcat atactacgca gcctctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gttatatctt caaatgaaca acctgaagtt tgaggacacg gccgtgtatt
      421 actgtgcgag agatgtgtac ggtagtgggt tagactactg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003241             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19861:15325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003241
VERSION     KCXD01003241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19861:15325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61723.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       441..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          120 a          144 c          146 g           97 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaactggt gcagtctggg gctgaaatga agaagcctgg ggcctcagtt
      181 agggtctcct gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata
      301 atacacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc cacagacaca
      361 gccttcatgg agttgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgaaa
      421 ggggggttcg gaaccagcgt ctggtccaac ctcttctacg gcttggattc ttggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003242             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23494:2052
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003242
VERSION     KCXD01003242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23494:2052"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..486
     V_segment       117..413
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61724.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       424..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          104 a          114 c          144 g          126 t
ORIGIN      
        1 acatggggga ttcccaggtg ttttcatttg tgatcagcac tgaacacaga agactcatca
       61 tggagtttgg cctgagctgg gttttccttg ttgctatttt aaaaggtgtc cagggtgagg
      121 tgcagttggt ggagtctggg ggcggcttgg caaagcctgg ggggtccctg agactctcct
      181 gtgcagcctc tggattcacc ttcagtgact actggatgta ctgggttcgc cagacacctg
      241 agcaggggct ggaatggatc tcagctattg atagtgctgg tactagtacc acatactatg
      301 cagactccgt gaagggcaga ttcaccatct ccagagagaa cgccaaaaac acactgtatc
      361 ttcagatgga cagcctgaga actgaggaca cggctgtcta ttactgtgcg agagttccgg
      421 gcctagtggt atttactggt tcgcttgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01003243             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13273:9512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003243
VERSION     KCXD01003243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13273:9512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61725.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          119 c          157 g          118 t
ORIGIN      
        1 acaggggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgt caggctccag ggaaggggct ggagtggatc tcaagtattg acagtggtgg
      301 gactaccaca aattatgcag actccgtgag gggcagcttc accatctcca gagagaacgc
      361 caagaacaga ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcgcgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003244             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14228:18841
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003244
VERSION     KCXD01003244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14228:18841"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61726.1"
                     /translation="CARDRIHYGLDSW"
     D_segment       441..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          120 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgacctgg gtccgccagg ctccagggaa gggtctggag tggatttcag gtgttaacag
      301 tggtggggat gacacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccagg aacacactgt atcttcaaat ggacagcctg agagttgaag acacggctgt
      421 ctattactgt gcgagagatc gaatacacta cggtttggat tcttggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003245             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12714:10860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003245
VERSION     KCXD01003245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12714:10860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..491
     V_segment       128..421
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61727.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       430..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          107 a          141 c          146 g           99 t
ORIGIN      
        1 acatggggga gcatcacata acaaccacct ccctcctcta aagaagcccc tgggaacaca
       61 gctcatcacc atggacctga cctggaggct cctctttgtg gtggcagcag ctacaggtgc
      121 ccagtcccag gtccagctgg tgcagtccgg ggctgatgtg aagaagcctg gggcctcagt
      181 gaaactctcc tgcaaggctt ctggattcgc cttcagaatg tatgccctca gttgggtgcg
      241 acaggcccct ggacaagggc ttgagtggat gggagggatc gtcccgcttg ttggaacaac
      301 aaactccgca cagaagttcc agggcagagt cacgattacc gcggacacgt ccataagcac
      361 agtctacatg gaactgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag
      421 aggcctgggt agcagcgccc actttggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003246             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18597:3549
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003246
VERSION     KCXD01003246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18597:3549"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61728.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           85 a          140 c          138 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggacgt atctctggcg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca tgtccaggaa ccagttctcc ctgcagctgg attatgtggc
      361 cgccgcggac acggccgtgt attactgtgc gagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003247             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18086:12488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003247
VERSION     KCXD01003247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18086:12488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..475
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61729.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       404..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          139 c          139 g          104 t
ORIGIN      
        1 acatggggga aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctctg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tgagcagtca ctactgcagc tggatccgcc agtccccagg gaagggactg
      241 gagtggattg gacggatctc tggtagtggt gggagcaccg actacaaccc ctccctcaag
      301 agtcgagtca ccctctcaac agacacgtcc aagaaggaga tctccctgaa gctgaactct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgcgag aagactatgg tggtaattat
      421 tactttaacc ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003248             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:27706:16560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003248
VERSION     KCXD01003248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:27706:16560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61730.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          115 c          154 g          125 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 catgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctctaga
      361 gacaattcca agaatacggt ttttctgcaa atgaattccc tgaaaatgga ggacacggcc
      421 gtgtattact gtgtgagagt ccatgactac gctatgtact actttgactc ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003249             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23274:5278
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003249
VERSION     KCXD01003249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23274:5278"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61731.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          108 a          124 c          154 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagttgg gtccgccagg ctccaggaaa ggggctggag tggatctcag gtattgccgc
      301 tgatggggat agcacatact atgcagactc catgaaggcc agattcacta tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagcagagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg atcaccgtct cctcagcc
//
LOCUS       KCXD01003250             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12783:9220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003250
VERSION     KCXD01003250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12783:9220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61732.1"
                     /translation="CAIGPSGTWNGWSFDVW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           99 a          145 c          140 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgtatatgg tgaaatggtg
      301 ttccagggcg gggtcaccat gaccgaggac acgtctacag acacagccta cttggagctc
      361 aacagcctga gctctgaaga cacggccgtg tactactgtg cgattggccc tagcggcacc
      421 tggaacggct ggtccttcga tgtctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003251             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8105:9927
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003251
VERSION     KCXD01003251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8105:9927"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61733.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          153 g          120 t
ORIGIN      
        1 acatggggag ggctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaac aaagaaattc tacgcagact ctctgaagga ccgcttcatc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaataacct gaaattagag gacacggccg
      421 tatatttctg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggtgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003252             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11183:14851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003252
VERSION     KCXD01003252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11183:14851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61734.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       418..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          141 c          131 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtaaagg agcctggggc ctcagtaaag
      181 gtctcctgca aggtttccgg attcaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagagt tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagttga gcagcctaag atctgaggac acggccctgt attactgtgc agtcggctat
      421 agcggcagat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01003253             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13775:12102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003253
VERSION     KCXD01003253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13775:12102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61735.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       422..435
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          137 c          152 g          103 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc ctctctgagg
      121 tccaactggt gcagtctggg gctgaggtga ggaagcctgg ggcctcagtg aaggtctcct
      181 gcaaggtttc cggagacacc ttcaccgatt tatccatgca ctgggtgcga caggcccctg
      241 gaaaagggct tgagtggttg ggaggtgttg atcctgcaaa tggtgaggta atacacgcag
      301 atagttttca gggcagagtc accatgaccg aggacacgtc tacactcaca gcctacatgg
      361 agctgagcgg cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga gggcggttcg
      421 gtagcagcgt ctggtccaat ctcgtctatg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003254             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21844:21021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003254
VERSION     KCXD01003254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21844:21021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61736.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          113 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgcttt ttcttcaaat ggacaacctg aaattggagg acacggccgt
      421 ctattattgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003255             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17016:5834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003255
VERSION     KCXD01003255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17016:5834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61737.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       423..432
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..496
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          149 c          137 g          102 t
ORIGIN      
        1 acatggggac atagcaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtacagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata caccttcaac atctatgcca tcaattgggt gcgacaggcc
      241 cctggacagg ggcttgagtg gatgggaggg atcatccctc ttgttgatat gacaaactac
      301 gcacagaggt tccagggcag agtcacgatt accgcggaca cgtccacaac cacagccttc
      361 ttggaactga gcagcctgag atctgacgac acggccattt attactgtgc gagagcccgg
      421 gcctacggta gcggctaccg ctcagactgg ttcttcgatg tctggggccc tggcacccca
      481 atcaccatct cctcagcc
//
LOCUS       KCXD01003256             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13145:8241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003256
VERSION     KCXD01003256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13145:8241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    72..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        72..426
     V_segment       72..365
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61738.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       371..377
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           92 a          101 c          127 g          108 t
ORIGIN      
        1 acatgggact caccatgaag tttgggctga gctgggtttt ccttgttgct attttaagag
       61 gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag cctggggggt
      121 ccctgagact ctcctgtgca gcctctggat tcaccttcag tacctctggc atgcactggg
      181 tccgccaggc tccagggaag gggctggagt ggctgacagt tatatcgtat gatgagacta
      241 agaaatacta cgcagactct gtgaagggcc gattcaccat ctccagagac aattccaaaa
      301 acatgctata tcttcaaatg aacaacctga aattggagga cgcggccgtg tattactgtg
      361 cgagagattc ttacggtcga ggctttgact cctggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01003257             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12073:7188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003257
VERSION     KCXD01003257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12073:7188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..491
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61739.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          111 a          119 c          152 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agctttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtgacagtt atatcgcatg
      301 atgaaactag gaaatactac gcagactctg ttagggaccg attcaccgtc tccagagaca
      361 attccaacaa catggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtac gagagacgca tttggcagcg gctgtgacta ctggggcctg ggagtcctgg
      481 tcaccgtctc cccagcc
//
LOCUS       KCXD01003258             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19072:7459
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003258
VERSION     KCXD01003258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19072:7459"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61740.1"
                     /translation="CARAHSGSWTNWSFDLW"
     D_segment       422..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          141 c          143 g           90 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gagggtcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agccaggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atatacggtc accgaaatat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggg ggtgttgatc ctctatatgg tgaaataata
      301 gaaggagaga agttcccggg cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagagcc
      421 catagcggca gctggaccaa ctggtccttc gatctctggg gccctggcac tccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003259             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:20125:8536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003259
VERSION     KCXD01003259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:20125:8536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61741.1"
                     /translation="CAKTYYSGTLEFW"
     D_segment       420..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..477
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           94 a          146 c          131 g          108 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggggcag aggtgagaag gcccggggag tctctgagga
      181 tctcctgtaa gacttctgga tacagcttta ccaccagctg ggtcagttgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccctc cttccaaggc cacgtcacta tctcagtcga caactccatc agtaccacct
      361 acctgcattg gagcagcctg aaggcctcgg acaccgccac atatttctgt gcgaaaacct
      421 actatagtgg tactttggag ttctggggcc agggagccct ggtcaccgtc gcctcagcc
//
LOCUS       KCXD01003260             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21447:7161
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003260
VERSION     KCXD01003260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21447:7161"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61742.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       441..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          116 c          150 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcgacctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagtt ttggcgtcca
      241 ctgggtccgc caggctccag ggaagggcct ggagtgggtg gcagttatat cgtctgatga
      301 aagtaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaagttg gaggacacgg ccgtctatta
      421 ctgtgcgaga gacgtatatg gcagcggctg tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003261             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24542:11526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003261
VERSION     KCXD01003261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24542:11526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..491
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61743.1"
                     /translation="CASGRTHWMELAALMGGLDSW"
     D_segment       412..417
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>499
                     /gene="IGHG"
BASE COUNT          111 a          135 c          151 g          102 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgagat gaagaagcct ggggcctctg tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga gttttccatg cactgggtgc gactggcccc
      241 tggaaaagga cttgagtgga tgggaggtgt tgatcctcta tctggtgaca taatacacgc
      301 agaaaagttc cagggcagag tcaccatgac cgaggacacg tctgcagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtctat tactgtgcga gtgggaggac
      421 acattggatg gagttggcgg ccttaatggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc ttgtcagcc
//
LOCUS       KCXD01003262             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17982:9792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003262
VERSION     KCXD01003262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17982:9792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61744.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          115 c          149 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaaactatgg
      241 catgcactgg gtccgccagg ccccagggaa ggggctggat tgggtggcag ttatgtcgtt
      301 tgatgaaaat gtgaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtatttctgt gcgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003263             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18262:15581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003263
VERSION     KCXD01003263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18262:15581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61745.1"
                     /translation="CVRYEDEYSDYHFDYW"
     D_segment       426..441
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           96 a          143 c          142 g          108 t
ORIGIN      
        1 acagggggag ggtccagctt acatgggaga tgctctctga gagtcatgga cctcctgtgc
       61 aagaacatga agcacctgtg gttcttcctt ctcctggtgg ctgctcccag atgggtcctg
      121 tcccagctgc atctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 ctcacctgcg ctgtctctgg tggctccatc agcaatagct actggaactg gatccgccag
      241 cccccaggga aggggctgga gtggattggg tctatctatg gtggtactgg gagcgccggc
      301 tacaacccct ccctcaagag tcgagtcacc gtttcaacag acacgtccaa gaaccagttt
      361 tccctgaagc tgacgtctgc gaccgccgcg gacaccgccg tgtattactg tgtgagatat
      421 gaggatgaat acagtgacta ccactttgac tactggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01003264             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:24674:11864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003264
VERSION     KCXD01003264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:24674:11864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61746.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       420..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          114 a          142 c          134 g           93 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaactggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 agggtctcct gcaaggtttc cggatacacc ttcaccgaat tatccataca ctgggtgcgg
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctctata tggtgaaatg
      301 aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc ctacatggaa
      361 ctgagtagtc tgacatttga ggacacggcc gtgtattact gtgcgactgg ccctagcggc
      421 acctggaacg cctggtacct cgatatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01003265             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17709:18525
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003265
VERSION     KCXD01003265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17709:18525"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..472
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61747.1"
                     /translation="CARAEYGSNLLPEYFDFW"
     D_segment       405..417
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..472
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>476
                     /gene="IGHG"
BASE COUNT           94 a          143 c          132 g          107 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aggccttcgg agaccctgtc cctcagttgc gctgtttctg
      181 gaggctccat cagcagtcac ttctggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg acgtatctct ggtattgttg ggaacaccga ctacaacccc tccctcaaga
      301 gtcgagtctc catttcaaaa gacacgtcca agaaccagtt cttcctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtatattact gtgcgagagc ggagtacggt agcaacttgc
      421 tccctgaata cttcgatttc tggggccagg gcgccctggt caccgtctcc tccgcc
//
LOCUS       KCXD01003266             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22435:5874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003266
VERSION     KCXD01003266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22435:5874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..478
     V_segment       118..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61748.1"
                     /translation="CARGHGLWSSPFDSW"
     D_segment       417..423
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          110 a          136 c          141 g           93 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccgcctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtcccc
      181 tgcaaggttt ccggatacat cgtcaccgat ttaaccatgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggaggtgtt gatcccagaa atggtgaaga aatgtacgga
      301 gacaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac agcctttttg
      361 gagctgacca gcctgagatc tgaggacacg gccgtctatt attgtgcgag aggacatgga
      421 ctgtggtcgt ccccttttga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003267             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16288:17925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003267
VERSION     KCXD01003267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16288:17925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61749.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          108 c          154 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagctt cggggttcat cttcagtagt tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagtaaca tcgtctgatg
      301 aaagtaagaa attctacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 cccagaacat actatatctt caaatgaaca acctgaaatt gaaggacacg gccgtctact
      421 attgtgggag agatgataat ggggtgatta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003268             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14076:11336
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003268
VERSION     KCXD01003268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14076:11336"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61750.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       406..414
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          136 c          137 g          107 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctctcctgca ctgtctctgg
      181 tggctccttc agtggttact actggacctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttatcggtg gtggtagtgg gagcaccgaa tacaacccct ccctcaaaag
      301 tcgagtcacc atgtcaagag acacgtccaa gaatcaattc tccctgaaga tgacctctat
      361 gaccgccgcg gacacggccg tttatttctg tgccagagat gcgggagtgg gagccacaat
      421 cctttactac tatgactact ggggccaggg agtccgggtc accgtctcct cagcc
//
LOCUS       KCXD01003269             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24709:7841
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003269
VERSION     KCXD01003269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24709:7841"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61751.1"
                     /translation="CARDVWGRGFDFW"
     D_segment       437..442
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          106 a          111 c          158 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcggc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acttttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt acatcgtctg
      301 atgaaactaa gaagtattat gcagactctg tgaaggcccg attcaccgtc tccagagaca
      361 attccaagaa catgttatat cttcaaatgg acaacctgaa attggaagac acggccgtgt
      421 attattgcgc gagagatgtc tgggggaggg gatttgactt ttggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003270             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:5301:14401
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003270
VERSION     KCXD01003270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:5301:14401"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61752.1"
                     /translation="CGNGARRTLGDYW"
     D_segment       392..396
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           80 a          137 c          139 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca cgaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccagatgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt atatcggtgg tactagtggg agcaccttct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgatgct gacctctgtg
      361 accgccgcgg acacggccgt ctatttttgt ggtaacgggg cccgacgtac tttgggggac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003271             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17425:16939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003271
VERSION     KCXD01003271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17425:16939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61753.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          140 c          148 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga gacaccttca gtgaaatgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggg gaaataatac
      301 acgcagataa cttccagggc agagtcacca tgaccgagga cacgtctata gacacagcct
      361 acatggagct gagtagcctg agatctgagg acacggccgt atattactgt gcgagcggga
      421 catttgggac cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcag cgtctcctca gcc
//
LOCUS       KCXD01003272             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15479:6914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003272
VERSION     KCXD01003272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15479:6914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..411
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61754.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       417..424
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          136 c          150 g          107 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct atagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccagctg gtgcagtccg gggctgaggt gaggaagcct ggggcctcag tgaagctctc
      181 ctgcaaggct tctggatata cgttcagcat ctatgccatc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagggat catccctctt gttgatgtaa caaactacgc
      301 acagaagttc cagggcagag tcacgattac cgcggacacg tccacaagca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat ttctgtgcga ggggagattg
      421 tactgatact gactgctctt ccgcgggggg cgcctttgat ttctggggcc aaggactcag
      481 ggtcaccgtc tcttcagcc
//
LOCUS       KCXD01003273             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10383:15409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003273
VERSION     KCXD01003273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10383:15409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61755.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       409..431
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          100 a          142 c          130 g          118 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga taccctgtcc ctcacatgcg ctgtctctgg
      181 tggctctatc agcagtacta aatggtggaa ctggatccgc cagcccccag ggaaagggct
      241 cgagtggatt gggtatatca gtggtagtag tggtaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa cagacacgtc caacaaccag ttctccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccttttatta ttgtgcgaga tcccaatcat attgtagtgg
      421 gctttactgc ttcggctact actactttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003274             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16488:22012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003274
VERSION     KCXD01003274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16488:22012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61756.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       443..448
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          112 a          123 c          152 g          117 t
ORIGIN      
        1 acatggggga gctctgggac aggagcccag ccctggaaga ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgaactgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcccctt cagtagctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtcatttcg
      301 tacgacgaaa ctaagaaata ctacgcagac tctctggagg accgattcac catctccaga
      361 gacaattcca agaacatgct ttatcttcag atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgcgcggag gccctggagt gcagatgcct ttgatttctg gggccaagga
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01003275             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16132:20364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003275
VERSION     KCXD01003275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16132:20364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61757.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       426..434
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..487
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          113 a          128 c          144 g          104 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc atagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccacc tggtgcagtc tggggctgag gtgaagatgc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata cagcgtcacc gaattatcca ttcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgatcctg taaaaggtga aataattcac
      301 ggagaggggt tccaggacag agtcaccatg accgaggacc cgtctacaga cacagcctac
      361 atggagttga gcaacctgag atcagaggac acggccgttt attattgtgc gagtgggttt
      421 agtatctggt tattttacga cgttctggat tcgtggggcc aaggggtcgt cgtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01003276             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11525:4594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003276
VERSION     KCXD01003276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11525:4594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61758.1"
                     /translation="CARDAGYGDTISLVDINMFPHFDYW"
     D_segment       414..437
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          101 a          137 c          139 g          118 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ctcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctggaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtgc tgtctccggt
      181 gcctccatca gcagttactg gtggagttgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg taatagtggt agtttttact acaacccttc cctcatcagt
      301 cgagtctcca tttcaaaaga cgcgtccaag aatcacttct ccctgaagct aagctctgtg
      361 accgccgcgg acacggccgt atattattgt gcgagagatg ccgggtatgg ggatacgata
      421 tcactagtcg atattaatat gttcccccac tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003277             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22482:9368
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003277
VERSION     KCXD01003277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22482:9368"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61759.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       432..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           95 a          149 c          133 g          113 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca cgactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggctact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg catatcagtg ggagtagtgg gagcaccgac tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaacag acacgtccaa gagccacttc tccctgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag ttttccccct acgactattc
      421 ttggagtgat ttttactctt actactttga ctacttgggc cagggactcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003278             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19799:11367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003278
VERSION     KCXD01003278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19799:11367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61760.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          115 a          144 c          138 g           95 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga accctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagaatcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct gtcatctgag gacacggccg tgtatttctg tgcgagtggc
      421 cctagcggca gttggaacgg ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01003279             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5399:19509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003279
VERSION     KCXD01003279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5399:19509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61761.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       448..453
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          118 c          154 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag agcacagagg actcaccatg aactttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttaaatcg
      301 tttgatggaa ccaagatata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgtgagaga tgcctacggg agcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01003280             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21562:3302
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003280
VERSION     KCXD01003280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21562:3302"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61762.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          127 c          155 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggaat ctgggggcgg cttggcacag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacaat
      301 ggtggggata ctaccttcta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgtc tcttcaaatg gacggcctca gagctgagga ctcggctgtc
      421 tattactgtg cgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003281             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19100:18281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003281
VERSION     KCXD01003281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19100:18281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61763.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          115 a          145 c          138 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gacgtgaaga agcctggggc ctctgtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatatctggg gccctggcac ccctatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01003282             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11094:13533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003282
VERSION     KCXD01003282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11094:13533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61764.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          145 c          134 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcag gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctgtatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac ttggaactga
      361 gcggcctgac ttctgaggac acggccgtgt attactgtgc gactggccct accggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003283             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12671:4356
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003283
VERSION     KCXD01003283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12671:4356"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61765.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       445..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          112 c          152 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcga
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cggaggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt ttctatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcgaatg
      301 atgaaactaa gaaatactac gcagactctg tgaaggaccg attcaccatt tccagagaca
      361 attccaagaa catgctattt cttcaaatgg acaacctgaa attggaggac acggccgtct
      421 attattgtgt gagagatgat ttaggcagcg gcttagggtc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003284             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18454:20044
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003284
VERSION     KCXD01003284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18454:20044"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61766.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          138 c          129 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtggctt ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattggct atatctatgg tagtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcaaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtatttctgt gcgagatatg gagatgatag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003285             364 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:9475:5864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003285
VERSION     KCXD01003285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 364)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 364)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:9475:5864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..360
     V_segment       7..298
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <290..>331
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61767.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       312..320
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>364
                     /gene="IGHG"
BASE COUNT           82 a           86 c          109 g           87 t
ORIGIN      
        1 acatggggtg catctggagg agtctggagg aggcttggtt cagcctgggg ggtccctgag
       61 actctcctgt gtaacctctg gattcacctt cagtagctat ggcatgcact gggcccgcca
      121 ggctccaggg aaggggctgg agtgggtggc agttatatcg tctgatggaa gtaagattta
      181 ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca agaacatgct
      241 ctatcttcaa atgaacaacc tgaaattgga ggacacggcc gtctattact gtgcgagaga
      301 ggagaaattt ggctacagtt ttgacttctg gggccaggga gtcctggtca ccgtctcctc
      361 ggcc
//
LOCUS       KCXD01003286             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:18183:2988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003286
VERSION     KCXD01003286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:18183:2988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61768.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       419..425
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          139 c          143 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaaa acttccaggg cagagtcacc atgaccgagg ccacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattattg tgcgagaggt
      421 gtgacagcag acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003287             308 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:28878:17707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003287
VERSION     KCXD01003287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 308)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 308)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:28878:17707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..306
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..306
     V_segment       8..231
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <225..>275
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61769.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       242..254
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       257..306
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        307..>308
                     /gene="IGHG"
BASE COUNT           70 a           88 c           90 g           60 t
ORIGIN      
        1 acatgggggt ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg
       61 tgcgacaggc ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg
      121 aaatgaagtt ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca
      181 tggaactgag cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggcccta
      241 ccggcaggtg gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct
      301 cctcagcc
//
LOCUS       KCXD01003288             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10911:20749
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003288
VERSION     KCXD01003288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10911:20749"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61770.1"
                     /translation="CARWSAANFDYW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          133 c          138 g           99 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga ggcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg atgtctcggg
      181 gggctccatc agtagtggtt atggctggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtgtctct acgatagtag tggaaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga agctgaggtc
      361 tatgaccgcc gcggacgcgg ccgtgtattt ctgtgcgaga tggtcggcag ccaactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003289             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18194:20589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003289
VERSION     KCXD01003289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18194:20589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..441
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <433..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61771.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       452..466
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          110 a          122 c          155 g          129 t
ORIGIN      
        1 acatggggga gctctaggag aggagcccag ccctgggatt cccaggtgtt ttcatttgtg
       61 atcagcactg aacacagaag actcatcatg gagtttggcc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gggtgaggtg cagttggtgg agtctggggg cggcttggca
      181 aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgactac
      241 tggatgtact gggttcgcca gacacctgag caggggctgg aatggatctc agctattgat
      301 agtgctggta ctagtaccac atactatgca gactccgtga agggcagatt caccatctcc
      361 agagagaacg ccaaaaacac actgtatctt cagatggaca gcctgagaac tgaggacacg
      421 gctgtctatt actgtgcgag agttccgggc ctagtggtat ttactggttc gcttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003290             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:6721:4589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003290
VERSION     KCXD01003290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:6721:4589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..431
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61772.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          117 a          121 c          147 g          129 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 ttctatatta aaaggtgtcc agtgtgtgga gcatctggtg gagtctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct gaattcacct tcagtgccta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtcta gaatgggtat caggtattaa
      301 cattggcggt gacccatact acccagactc tgtgaagggt cgattcacca tctccagaga
      361 caatgccaag aactccttgt atcttcaaat gaacaacctg agagctgagg acactgctgt
      421 gtattattgt gtgaggggga tggataacta ccactacagt aatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003291             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:22388:11765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003291
VERSION     KCXD01003291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:22388:11765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61773.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          114 c          148 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacattg ggtccgccag gctccaggga aggggctggg gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgctaact ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003292             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14191:14685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003292
VERSION     KCXD01003292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14191:14685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..469
     V_segment       107..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61774.1"
                     /translation="CARWAEDDYGYFRFDYW"
     D_segment       402..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          136 c          136 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa ccacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaagtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtagttt ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatgtatgg gggtagtggg agcaccacct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gagttctgtg
      361 accgccgcgg acaccgccgt ctattactgt gcgagatggg ccgaggacga ttacggttac
      421 tttagatttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003293             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10225:14443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003293
VERSION     KCXD01003293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10225:14443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61775.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          110 a          144 c          135 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgatttat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctgcag acacagccta catggaactg
      361 agtagcctga catctgagga cacggccgtg tattactgtg cgactggccc tagcggcacc
      421 tggaacgcct ggtacctcga aatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003294             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9168:5405
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003294
VERSION     KCXD01003294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9168:5405"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61776.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       444..448
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          138 c          143 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt cagcgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaaggacttg agtggatggg aggtgttgat actgtatctg atggagtgat
      301 atacgcagag aacctccagg gcagagtcgc catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ttgagcagcc tgagatctga ggacacggcc gtttattact gtgcgagagg
      421 tttatcacca gacgtcttcg gtttcctcgg gcttggctac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01003295             277 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16651:3903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003295
VERSION     KCXD01003295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 277)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 277)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16651:3903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..275
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..275
     V_segment       8..187
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <179..>244
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61777.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       201..220
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       233..275
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        276..>277
                     /gene="IGHG"
BASE COUNT           65 a           70 c           76 g           66 t
ORIGIN      
        1 acatgggcag gctccgggaa aggggctgga gtgggtctca tatattagtt acactggtaa
       61 aaccatatac tactctgact ccgtgaaggg ccgattcacc atctccagag acaacgtcaa
      121 gaactctctg tctctgcaaa tgagcagcct gagagccgag gacacggccg tgtattattg
      181 ttctagagcg gcttacgaac atgatgacgg ttactattac gtcggcaggt tttttgactg
      241 ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003296             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15835:10085
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003296
VERSION     KCXD01003296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15835:10085"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61778.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          112 c          155 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagtg caactggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcagctt cagtggcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata ttacgcagac tctgtgaagg accgattcac cgtctccaga
      361 gacaattcca agaacatgct atattttcaa atgaacaacc tgaaattgga agacacggcc
      421 gtgtattact gtgcgagaga tgtctatggc aggggacttg actactgggg cctgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003297             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17985:7772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003297
VERSION     KCXD01003297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17985:7772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61779.1"
                     /translation="CVRRPFGSDAFDFW"
     D_segment       447..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          114 c          150 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga aatttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatgaaaa taagaaatac tacgtagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gcaattggag gacacggccg
      421 tgtattattg tgtgagacga ccgttcggta gtgatgcttt tgatttctgg ggccaagggc
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01003298             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19593:5202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003298
VERSION     KCXD01003298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19593:5202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61780.1"
                     /translation="CAREYCTTDDCAGFFDYW"
     D_segment       418..425
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          133 c          140 g          105 t
ORIGIN      
        1 acatggggat cacaaaacaa ccgcatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agttgatcca gtccggggct gaggtcaaga agcctggggc cgcagtgaag
      181 gtttcctgta aggcctctgg attcaccctc gacaactatg gtatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccaagttgg tataataaat
      301 tacggtgaga gattccagga cagagtcacg attagcgcgg acacgtccat gaatatggcc
      361 tacatggagg tgaccagcct gaaatccgac gacacggcca tctatttctg tgcgagagaa
      421 tactgcacca ctgatgattg cgccggattc tttgactact ggggccaggg agtcctggtc
      481 accgtctctt cagcc
//
LOCUS       KCXD01003299             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:2544:15820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003299
VERSION     KCXD01003299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:2544:15820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61781.1"
                     /translation="CARYEAGTTLIDYW"
     D_segment       402..413
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           92 a          140 c          130 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccgtca ccagcaccta ctggagctgg atccgccagc ccccagggaa aggactggag
      241 tggattggct atatctatgg tggtagtggg agtaccggct acaacccctc cctcaggagt
      301 cgagtcgaca tttcgacaga cacgtccaac aaccagtttt ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt ctactactgt gcgagatatg aagctggaac aaccctaatt
      421 gactactggg gccagggagt cctggtcatc gtctcctcag cc
//
LOCUS       KCXD01003300             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11787:11631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003300
VERSION     KCXD01003300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11787:11631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..480
     V_segment       102..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61782.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       413..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT           98 a          136 c          142 g          106 t
ORIGIN      
        1 acatgggggg ctccctgaga gtcatggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag tcttcggaga ccctgtccct cacctgcgct gtctctggtt
      181 actccatcaa cagtggttac tactactggg gctggatccg tcagccccca gggaaggggc
      241 tggagtggat tgggtatata ggtggtagta ctgggagcgc ctactacaac cccgccctca
      301 agagtcgagt tgccatttca aaagacacgt ccaagaacca gttctccctg aagctgaggt
      361 ctgtgaccgc cgcggacacg gccgtgtatc actgtgcgag acatggaggt ttctatagtg
      421 cgactgacaa gtcaacattt gacaactggg gccagggagt cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01003301             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11975:5232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003301
VERSION     KCXD01003301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11975:5232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61783.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       451..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          107 a          126 c          156 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttaatgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaacg
      301 ctggtgggga taccacatac tatgcagact ccgtgaaggg cagatccacc atctccagag
      361 agaacgccaa gaacacactg catcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003302             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5611:6120
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003302
VERSION     KCXD01003302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5611:6120"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61784.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       445..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          110 c          157 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cagcttcagt atctttggca
      241 tgcattgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atgtcgaatg
      301 atggaagtaa gaaatactac acagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa aatgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgcgc gagagacgat tttggcagcg gcttagggta ctggggccag ggagccctgg
      481 tgaccgtctc ctcagcc
//
LOCUS       KCXD01003303             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8546:7822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003303
VERSION     KCXD01003303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8546:7822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61785.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       423..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          142 c          142 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctctatatgg tgaaatgatg
      301 cacgcagaca acttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgac gacacggccg tgtattactg tgcgcgtggg
      421 cctattacaa tttttggcgt acttattacg gggcttgact attggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003304             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14690:7490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003304
VERSION     KCXD01003304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14690:7490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61786.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       433..439
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          141 c          143 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaaat gaagaagcct ggggcctcag ttagggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt cgatcctgca caaggtgaaa taatacacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagccttcat
      361 ggagttgagc agcctgagat ctgaggacac ggccgtgtat ttctgtgcga aaggggggtt
      421 cggaaccagc gtctggtcca acctcttcta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003305             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:11801:4469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003305
VERSION     KCXD01003305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:11801:4469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..336
     V_segment       8..261
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61787.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       269..277
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..336
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           76 a           90 c           93 g           79 t
ORIGIN      
        1 acatggggaa gcctggggcc tcagtgaggg tctcctgcaa ggtttccgga cacaccttca
       61 gcgaattatc cattcactgg gtgcgacagg cccccggaaa agggcttgag tgggtgggag
      121 gttttgctcc tatatatggt gaaatcctac acacagacaa gttccagggc agagtcacct
      181 tgaccgagga cacgtctaca gacaccgcct atatggagtt gagcagcctg agatctgagg
      241 acacggccgt atattactgt gtggcggctg atagtggtta ccctttttac tacttcgata
      301 tctggggccc tggcacccca atcatcatct cctcagcc
//
LOCUS       KCXD01003306             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11309:15446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003306
VERSION     KCXD01003306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11309:15446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..504
     V_segment       128..421
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61788.1"
                     /translation="CARGGFGTSVWSNLFYGLDSW"
     D_segment       442..448
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>508
                     /gene="IGHG"
BASE COUNT          117 a          141 c          152 g           98 t
ORIGIN      
        1 acatggggga gagcaccaca caacaaccac atccctcgcc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc
      121 ccactctgaa gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaaggtcgcc tgcaaggttt ccggaaacac cttcaccgaa ttattcatgc actgggtgcg
      241 acaggcccct ggaaaagggc ttgagtggat gggaggtgtc gatcctgctc aaggtgaaat
      301 aatatacgca gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac
      361 agccttcatg gagttgagca gcctgagatc tgaggacacg gccgtgtatt tctgtgcgag
      421 aggggggttc ggaaccagcg tctggtccaa cctcttctac ggtttggatt cctggggcca
      481 aggggtcgtc gtcaccgtct cctctgcc
//
LOCUS       KCXD01003307             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23061:18583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003307
VERSION     KCXD01003307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23061:18583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61789.1"
                     /translation="CATGTIGSSVWSNLFTGLDSW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          144 c          144 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgtaaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tgggaaaggg cttgagtgga tgggagttgt tgatcctgtc aatggtgaag aaatacacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tcgacagaca cagcctacat
      361 ggacttgacc agtctcagat ctgaggacac ggccatctat tattgtgcga cagggacgat
      421 cggtagcagc gtctggtcca acctcttcac cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003308             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21702:7563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003308
VERSION     KCXD01003308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21702:7563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61790.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          142 c          137 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact gggcctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccaggtctcc ctgaaagtga cttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcatc gtctcctcag cc
//
LOCUS       KCXD01003309             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:21060:2252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003309
VERSION     KCXD01003309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:21060:2252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..430
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61791.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       437..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          112 a          119 c          154 g          118 t
ORIGIN      
        1 acatggggag agaggagcct tagccctgga tttcaaggca cttccacctg gggatcagca
       61 ctgaacacag aggacccacc atggagttgg ggctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggaggcttg gtccagcctg
      181 gagggtctct gagactctcc tgtgtagcct ctggattcag cttcagaagt tacgaaatga
      241 gttgggtccg ccaggctccg ggaaagggac tggagtgggt ctcatatatt agtcacactg
      301 gtgaaaccat ataccacgct gactccgtga agggccgatt caccatctcc agagacaacg
      361 ccaagaattc gctgtctctg caaatgagca gcctgagagc cgaggacacg gccgtatatt
      421 actgtactag aaaccggaat actgtaatga ttgggtggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003310             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:19099:6470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003310
VERSION     KCXD01003310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:19099:6470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61792.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          117 a          144 c          128 g           90 t
ORIGIN      
        1 acatggagca tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggg aaagtagact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccac ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003311             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18736:6809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003311
VERSION     KCXD01003311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18736:6809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61793.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          133 c          131 g          109 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag tcttcggaga ccctgtctct cacctgcggt gtctctggtg
      181 actccatcag caatagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgactg ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003312             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12266:12892
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003312
VERSION     KCXD01003312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12266:12892"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61794.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgagcaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003313             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21472:10114
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003313
VERSION     KCXD01003313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21472:10114"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61795.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       438..443
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          117 c          144 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctcccggga agggtctgga gtgggtagca gttatctccc
      301 atgatgaaaa taatatatat tacgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaacgta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttttactg tgtgagagat acattcggtt caggatttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003314             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16459:19410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003314
VERSION     KCXD01003314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16459:19410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61796.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       431..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          139 c          149 g           99 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagac cggggctgcg gtgaagaagc ctggggcctc agttaagctc
      181 tcctgcaagg cttctggata caccttcagc atctatgtca tcaattgggt gcgccaggcc
      241 cctggacaag ggctagagtg gatgggaggg atcatccctc ttgttggtac aacaaactac
      301 gcacagaggt tccagggcag agtcacgatt attgcggaca cgtccacaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcccc
      421 cctactgaag ggggtgatta ttctgggggg gctttgagcc gatggggcca gggagtccag
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003315             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20590:14673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003315
VERSION     KCXD01003315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20590:14673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61797.1"
                     /translation="CAREKYYSGSYKHNWFDVG"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          135 c          138 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccttcagc ggtttctatt ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggtat atcagtgcta gtagtgggag taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaataa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtcg ggggcccggg agtccaggtc accgtctcct cagcc
//
LOCUS       KCXD01003316             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15362:10005
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003316
VERSION     KCXD01003316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15362:10005"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61798.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          144 c          148 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg ggctggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggagc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgactta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg agttgttgat cctgtaaatg gtgaaatgat
      301 acacgcagag atgttccagg ccagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcggt agcagcgtct ggtccagcct cttcaacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003317             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8280:16716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003317
VERSION     KCXD01003317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8280:16716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..515
     V_segment       152..443
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61799.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       453..470
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          103 a          157 c          135 g          122 t
ORIGIN      
        1 acatggggag tctccctcac cacccagctg gggatctcag tgcttcattt tctgtccttc
       61 atttctcagt gcttcatttc tgtcctccac cacgatgggg tcaactgcca tcctcgccct
      121 cctcctggct gttctccaag gagtctgtgg cgaggtgcag ctggtgcagt ctggagcaga
      181 ggtgaaaagg cccggggaat ctctgaggat ctcctgtaag acttctggat acagctttac
      241 cacttactgg atcaattggg tgcgccagat gcccgggaaa ggcctggagt ggatgggaat
      301 gatctatcct agtgattctg atcccagata cagcccgtcc ttccaaggcc aggtcaccat
      361 ctcagccgac aagtccatca gcaccgccta cctgcagtgg agcagcctga aggcctcgga
      421 caccgccacg tattactgtg cgagagctgg acgatacacc tacagttacc cctttgacta
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003318             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11005:7823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003318
VERSION     KCXD01003318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11005:7823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61800.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          134 c          137 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcggc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003319             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16503:16913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003319
VERSION     KCXD01003319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16503:16913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61801.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          145 c          145 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtttg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgtaaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tgggaaaggg cttgagtgga tgggagttgt tgatcctgcc aatggtgaag aaatacacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tcgacagaca cagcctacat
      361 ggacttgacc agtctcagat ctgaggacac ggccatctat tactgtgcga cagggaggat
      421 cggtagcagc gcctggtcca acctcttcac cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003320             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18353:4713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003320
VERSION     KCXD01003320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18353:4713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61802.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       350..355
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..410
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           89 a           93 c          122 g          108 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc ggtgtgaggt
       61 gcaattggtg gagtctggag gaggcttggt tcaacctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtaactt tggcatacac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cagttatttc gtctgatgga agtaacaaat actacacaaa
      241 ctctgtgaag agccgattca ccgtctccag agacaattcc cagaacatac tttatcttca
      301 aatgaacaac ttgaaattgg aggacacggc cgtctattac tgtgcgagag atgatcttgg
      361 gaccggtttt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003321             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15478:14608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003321
VERSION     KCXD01003321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15478:14608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61803.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          113 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggaggg ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcat
      301 ctgatggaag taagaaatac tacgcaaact ctgtgaagga ccgattcatc atctccagag
      361 acaattccaa gaacatagta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatatgggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003322             310 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11013:10970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003322
VERSION     KCXD01003322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 310)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 310)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11013:10970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..308
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..308
     V_segment       8..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>277
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61804.1"
                     /translation="CARVGEATGGAEDFDFW"
     D_segment       247..253
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       264..308
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        309..>310
                     /gene="IGHG"
BASE COUNT           74 a           74 c           91 g           71 t
ORIGIN      
        1 acatggggca gcctccggat tcaccttcag tagctttggc atgcactggg tccgccaggc
       61 tccagggaag ggactggagt gggtggcact gatatcgtat gatggaaata agaaatacta
      121 cgcagactct gtgaaggacc gattcaccct ctccagagac aattccgaga acatcctata
      181 tcttcaaatg aacaacctga aattggagga cacggccgtg tatttttgtg cgagagttgg
      241 agaggctact ggtggtgcgg aggactttga cttctggggc cagggagtcc tggtcaccgt
      301 ctcctcagcc
//
LOCUS       KCXD01003323             395 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11186:11393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003323
VERSION     KCXD01003323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 395)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 395)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11186:11393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..393
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..393
     V_segment       33..326
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <318..>362
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61805.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       336..343
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       346..393
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        394..>395
                     /gene="IGHG"
BASE COUNT           69 a          117 c          124 g           85 t
ORIGIN      
        1 acatgggggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag tcgggccctg
       61 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt ggctccttca
      121 gcggttacta ctggggctgg atccgccggc ccccagggaa ggggctggag tggattgggt
      181 atatcagtgg gagtagtggg agcaccgact acaagtcctc cctccagagt cgagtcacca
      241 tttcaacaga cacgtccaag aaccagttct ccctggagtt gagttctgtg accgccgcgg
      301 acacggccgt gtattactgt gcgagagtcc ggggcgttac tatccactac tttgactact
      361 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003324             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22952:10589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003324
VERSION     KCXD01003324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22952:10589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..436
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61806.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       382..387
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..436
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           91 a          129 c          121 g           97 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccaggt ccagttgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacctg cgctgtctct ggtgactcca tcagcggtta ctactggaac
      181 tggatccgcc aaccaccagg gaaggggctg gagtggattg ggtttatcgc tggtagtagt
      241 gggaccacca actacaaccc ctccctcaag agtcgagtca ccatctcaac agacacgtcc
      301 aagaaccagt tctccctgaa cctgaactct gtgaccgccg cggacacggc catgtattac
      361 tgtgcgagaa atagatttat gggtattaga gttcttgcct actggggcca gggagtcctg
      421 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003325             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21951:20307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003325
VERSION     KCXD01003325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21951:20307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61807.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       438..446
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          113 c          147 g          120 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg cgattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agccggaggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg gcttgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gtaatttcga atgatgaaaa
      301 taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag acaattccat
      361 gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg tctattactg
      421 tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003326             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10210:7885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003326
VERSION     KCXD01003326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10210:7885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61808.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          101 a          128 c          156 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaccagt
      301 ggtggggcta acacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga ccacactgta tcttcacatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg ttagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003327             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:9161:19138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003327
VERSION     KCXD01003327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:9161:19138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..435
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61809.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       452..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          107 a          125 c          158 g          126 t
ORIGIN      
        1 acatgggggc agctctgaga caggagtctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtggag ctggtggagt ctgggggagg cttggtccag
      181 ccgggggggt ccctgagact ctcctgtgta gcctctggat tcacctttgg tgattatggc
      241 atgcactggg tccgccaggc tccgggaaag ggactggagt gggtctcatc catcagaaac
      301 actggtaaaa tcgtatacta cgctgactcc gtgaagggcc gattcatcat ctccagagac
      361 aacgccaaga attcgctgtc tctgcaaatg agcagcctga gagtcgagga ctcggccgtc
      421 tattactgta ctagaattgg cgtcggatct ctagcaccgg ctggtgaata ctttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003328             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:17830:11637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003328
VERSION     KCXD01003328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:17830:11637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61810.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       425..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          139 c          151 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag taaaggtctc
      181 ctgccaggtt tccggataca ccttcagtga aatgtccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt tgctcctgga aatggtgaaa taatacacgc
      301 agagagcttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagt agcctgagat ctgaggacac ggccgtgtat tactgtgcga cagggaggtt
      421 cgggagcagc gtctggtcca gcctcttcta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003329             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7280:11214
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003329
VERSION     KCXD01003329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7280:11214"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..496
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61811.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       432..438
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          118 a          141 c          142 g           97 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccaactgg tgcagtctgg ggctgaaatg aagaagcctg gggcctcagt tagggtctcc
      181 tgcaaggttt ccggaaacac cttcaccgaa ttatccatgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggatgtgtc gatcctgcac aaggtgaaat aatacacgca
      301 gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac agccttcatg
      361 gagttgagca gcctgagatc tgaggacacg gccgtgtatt tctgtgcgaa aggggggttc
      421 ggaaccagcg tctggtccaa cctcttctac ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003330             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13474:16952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003330
VERSION     KCXD01003330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13474:16952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61812.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          143 c          138 g           99 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag ggtcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 ccctgcaagg cttctggata caccctcagc atctctacca tcagttgggt acgacaggcc
      241 cctggacaag ggcttgagtg gatgggggag atcttccctc ttgttggtaa aacaaaatac
      301 gcacagaagt tccacggcag agtcacgatt accgcggaca cgtccgcaag tacagcctac
      361 atggagctga gtggcctgaa atctgaggac acggccgtct attactgtgc gaaaagaggt
      421 ggccacggta ccaccaccac gttgtacttc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003331             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6233:8508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003331
VERSION     KCXD01003331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6233:8508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61813.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatccactg ggtccgccag gctccgggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaac aaagaaattc tacgcaggct ctctgaagga ccgcttcatc atctccagag
      361 acaactccaa gaacatggta tatcttcaaa tgaatagcct gcaattggag gacacggcca
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggtgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003332             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13589:6513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003332
VERSION     KCXD01003332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13589:6513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..493
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61814.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       432..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          116 a          142 c          143 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggctgg gaggtgttga tcttgcatat gatgaaataa
      301 tacacgcaga gaagttccaa ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcggcgg
      421 gccttggggg atatttactg ctcactgaat acctcgagtt ctggggccag ggcgccctgg
      481 tcaccgtctc ctccgcc
//
LOCUS       KCXD01003333             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23138:14301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003333
VERSION     KCXD01003333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23138:14301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..495
     V_segment       142..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61815.1"
                     /translation="CATADYGNSLDYW"
     D_segment       439..450
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>498
                     /gene="IGHG"
BASE COUNT          110 a          117 c          149 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taactttggc
      241 atgcactggg tccgccaggg tccagggaag gggctggagt gggtggcagt tatatcgtct
      301 gatggaagtt tcaaatacta cgcagactct gtgaagggcc gattcaccat ttccagagac
      361 aattccaaga acatggtata tcttcaaatg aacaacctga aattggagga cactgccctt
      421 tattactgtg cgacagccga ctacggtaac agccttgact actggggtca gggagtcctg
      481 gtcaccgtct cctcaacc
//
LOCUS       KCXD01003334             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22378:15925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003334
VERSION     KCXD01003334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22378:15925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..279
     V_segment       8..202
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61816.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       207..227
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       229..279
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           65 a           78 c           82 g           56 t
ORIGIN      
        1 acatgggatc cattcactgg gtgcgacagg cccctggaaa agggcttgag tggatgggag
       61 gcgttgatcc tgcatatggt gaatttacac ccggagagaa gttccagggc agagtcacca
      121 tgaccgagga cacgtctata gacacagcct acatggagct gagcagcctg aactctgagg
      181 acacggccgt ctattactgt gcagccgggt atagcggcag ctggaaccac tggtacttcg
      241 atctctgggg ccctggcacc cctatcacca tctcctcagc c
//
LOCUS       KCXD01003335             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:3758:15750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003335
VERSION     KCXD01003335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:3758:15750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..439
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61817.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       450..464
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          108 a          122 c          156 g          128 t
ORIGIN      
        1 acatgggggc tctaggagag gagcccagcc ctgggattcc caggtgtttt catttgtgat
       61 cagcactgaa cacagaagac tcatcatgga gtttggcctg agctgggttt tccttgttgc
      121 tattttaaaa ggtgtccagg gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactactg
      241 gatgtactgg gttcgccaga cacctgagca ggggctggag tggatctcag ctattgatag
      301 tgctggtagt agtaccacat actatgcaga ctccgtgaag ggcagattca ccatctccag
      361 agagaacgcc aaaaacacac tgtatcttca gatggacagc ctgagaactg aggacacggc
      421 tgtctattac tgtgcgagag ttccgggcct agtggtattt actggttcgc ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003336             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18659:9413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003336
VERSION     KCXD01003336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18659:9413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61818.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          122 a          141 c          134 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003337             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17364:8168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003337
VERSION     KCXD01003337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17364:8168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61819.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       404..415
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          141 c          137 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctttgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtaact actgggcctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctctg gtagtggtgg gagcaccgtc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaactg acacgtccaa gaaccaggtc tccctgaaag tgacttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgacagcc ggatatagca gcagcgaaag
      421 cttctacggt ttggattcct ggggccaagg ggtcgtcgtc atcgtctcct cagcc
//
LOCUS       KCXD01003338             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20854:8135
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003338
VERSION     KCXD01003338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20854:8135"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61820.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          101 a          125 c          156 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actacttcat
      241 gagttgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta tttccagtgg
      301 tggggatagc acatactctg cagactccgt gaagggcaga ttcaccattt ccagagagaa
      361 cgccaagacc acactgtatc ttcacatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgca agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003339             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20851:16957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003339
VERSION     KCXD01003339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20851:16957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..445
     V_segment       91..384
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61821.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       394..399
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..445
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          104 a          100 c          133 g          110 t
ORIGIN      
        1 acatgggtca gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc
       61 cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc
      121 ttggttcagc cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt
      181 acctatggca tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtgacagtt
      241 atatcgtatg atgaaacaaa gaaatactac gcagactctc tgaaggaccg cttcatcatc
      301 tccagagaca attccaagaa catggtatat cttcaaatga ataacctgaa attggatgac
      361 acggccgtat attactgtgt gagagatgtc aggggaacgg ggtttgactt ctggggccag
      421 ggtgtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003340             402 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19048:13614
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003340
VERSION     KCXD01003340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 402)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 402)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19048:13614"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    46..400
                     /note="immunoglobulin heavy chain variable region"
     V_region        46..400
     V_segment       46..339
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <331..>369
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61822.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       348..359
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       361..400
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        401..>402
                     /gene="IGHG"
BASE COUNT           87 a           88 c          126 g          101 t
ORIGIN      
        1 acatgggggg ttttccttgt tgttatttta agaggtgtcc agtgtgaggt gcagctggtg
       61 gagtctggag gaggcttggt tcagccgggg gggtccctga gactctcctg tgcagcctct
      121 ggattcacct tcagtaatta tggcatgcac tgggtccgcc aggctccagg gaaggggctg
      181 gaatgggtgg cagttatgtc gtctgatgga actaagacat tctacgcaga ctctgtgaag
      241 gtccgattca ccatctccag agacaattcc aagaacatgc tatatcttca aatgaacagc
      301 ctgaaatcgg aggacacggc cgtgtattac tgtgggagag atgataatgg ggtgattatc
      361 gactactggg gccagggagt cctggtcacc gtcgcctcag cc
//
LOCUS       KCXD01003341             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9372:7111
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003341
VERSION     KCXD01003341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9372:7111"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61823.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           95 a          137 c          130 g          108 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003342             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12215:7518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003342
VERSION     KCXD01003342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12215:7518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61824.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           99 a          139 c          134 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccctcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atcagtgcta gtagtggaaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgcccaagaa ccagttctcc ctgatgctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003343             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17263:14393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003343
VERSION     KCXD01003343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17263:14393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..484
     V_segment       100..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61825.1"
                     /translation="CARSQSYCGGLYCFGYYYFDYW"
     D_segment       419..427
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           92 a          144 c          132 g          118 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgcagcc ttcggagacc ctgtccctca catgcgctgt ctctggtggc
      181 tctttcagca gtactaaatg gtggagttgg atccgccagc ccccagggaa agggctggag
      241 tggattgggt atatcagtgg tagtagtggt aacaccttct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacgga cacgtccaac aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt ttattattgt gcgagatccc aatcctattg tggtggcctt
      421 tactgcttcg gctactacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01003344             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23558:13482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003344
VERSION     KCXD01003344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23558:13482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..464
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61826.1"
                     /translation="CARYEDDSGHYYFDSW"
     D_segment       405..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>468
                     /gene="IGHG"
BASE COUNT           89 a          134 c          130 g          115 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacttgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gttgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcatctgcgc tgtctctggt
      181 ggctccatca ccagtagctt ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatatatgg tagtactggg agttccagtt ccaacccctc cctcaagagt
      301 cgagtcacca tttcaacgga cacgtccaag aaccagtttt ccctgaaact gagctctgtg
      361 accgccgcgg acaccgcctt ttatttctgt gcgagatatg aagatgatag tggtcattac
      421 tactttgact cctggggcca gggagtcctg gtcaccgtct cctcggcc
//
LOCUS       KCXD01003345             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19657:17319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003345
VERSION     KCXD01003345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19657:17319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61827.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       451..455
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          104 a          123 c          156 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt actactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggtc ttgccagtgg
      301 tggggatagc acatactatg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgcatc ttcaaatgga cagcctgaga gttgaagaca cggctgtcta
      421 ttactgtgtg agagatcgac gtgttcagtc attatcctgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003346             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23385:10334
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003346
VERSION     KCXD01003346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23385:10334"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61828.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctgtcctgtg cagcctctgg attcaccttc attaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tgtattactg tgcgagagga gactacggta acagccttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01003347             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13669:19551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003347
VERSION     KCXD01003347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13669:19551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..502
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61829.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       438..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          111 a          120 c          155 g          118 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcagttg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtctc tgagactctc ctgtgtagcc tctggattca gcttcagaag ttacgaaatg
      241 agttgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagtcacact
      301 ggtgaaacca tataccacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccctatat
      421 tactgtacta gaaaccggaa tactgtaatg attgggtggt tcgatgtctg gggcccggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003348             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22254:13879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003348
VERSION     KCXD01003348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22254:13879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61830.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgcacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003349             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13763:20819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003349
VERSION     KCXD01003349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13763:20819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61831.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          139 c          134 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcactg tctccggtgg
      181 ctccttcagt ggttactact ggacctggat ccgccagccc ccaggaaagg ggctggagtg
      241 gattgggttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa tcaattctcc ctgaagctga cctctatgac
      361 cgccgcggac acggccgttt atttctgtgc cagagatgcg ggagtgggag ccacaatcct
      421 ttactactat gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003350             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22320:15436
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003350
VERSION     KCXD01003350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22320:15436"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61832.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       438..444
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          115 c          144 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccggtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcaac
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtgacagtt atttcgtctg
      301 atggaactaa caaatactac gcaaactctg tgaagagccg attcaccatc tccagagaca
      361 attccaagaa catactatat cttcaaatga acaacttgaa attggaggac acggccgtct
      421 attactgtgc gagagatgat attgggaccg gttttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003351             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11680:22253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003351
VERSION     KCXD01003351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11680:22253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..447
     V_segment       93..386
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61833.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       388..392
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..447
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           97 a          103 c          136 g          113 t
ORIGIN      
        1 acatggggat cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt
       61 tccttgtttc tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag
      121 gcttggttca gcctggggag tccctgagac tctcctgtgc agcctctgga ttctccttca
      181 gtagctctgg catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtgtctg
      241 taatttcgtc tgatggaagt aacaaatact acggagactc tgtgaaggac cgattcacca
      301 tctccagaga caactccagg aacatactat atcttcaaat gaacaacctg aaattggagg
      361 acacggccgt gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc
      421 aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003352             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12646:4181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003352
VERSION     KCXD01003352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12646:4181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61834.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          111 a          121 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaggttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg atatctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003353             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:24055:17652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003353
VERSION     KCXD01003353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:24055:17652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..456
     V_segment       105..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61835.1"
                     /translation="CASNSITSGPDYW"
     D_segment       400..406
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           90 a          140 c          125 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgagg cacctgtggt
       61 tcttcctcct cctggcggca gctcccagat gggtcctgtc ccgcctgcag ctgcaggcgt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctct cacctgcgct gtctctggtg
      181 cctctatcag cggtaactac tggagctgga tccgccaggc cccagggaag ggactggagt
      241 ggattggata tatctatggt agtgatatta gtaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagttctc cctgaacctg gcctctgtga
      361 ccgccgcgga cacggccatc tatttctgtg ccagtaacag tataacatct ggtccagact
      421 attggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003354             356 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17942:12562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003354
VERSION     KCXD01003354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 356)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 356)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17942:12562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..354
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..354
     V_segment       8..287
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>323
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61836.1"
                     /translation="CARTSGGWSPYFDFW"
     D_segment       290..305
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       308..354
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        355..>356
                     /gene="IGHG"
BASE COUNT           70 a          107 c          103 g           76 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg
       61 ctgtctctgg tgactccatc agcagtacct attggagctg gatccgccag cccccaggga
      121 agggactgga gtggattgga cgtatctctg gtggtggtgg gaacaccgac tacaacccct
      181 ccctcaagag tcaagtcacc atttcaagag acacgtccag gaaccagttc tccctgcagc
      241 tgaattatgt gaccgccgcg gacacggccg tatattactg tgcgagaact agcggtggct
      301 ggtcccccta ctttgacttt tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003355             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24106:16999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003355
VERSION     KCXD01003355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24106:16999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..490
     V_segment       137..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61837.1"
                     /translation="CATADYGNSLDFW"
     D_segment       434..445
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          113 a          118 c          144 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtcgggg ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagct ttggcttgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtctgatgg
      301 aaatatgaaa tactacgcag actctatgaa ggaccgattc accatctcca gagacaattc
      361 caagaacata ctatatcttc aagtgaacaa cctgaaattg gaagacactg ccgtttatta
      421 ctgtgcgaca gccgactacg gtaacagcct tgacttctgg ggccagggag tcctggtcac
      481 cgtctcctca acc
//
LOCUS       KCXD01003356             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13113:8038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003356
VERSION     KCXD01003356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13113:8038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61838.1"
                     /translation="CASNSITSGPDYW"
     D_segment       399..405
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          141 c          128 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag gcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cgcctgcagc tgcaggcggc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgg
      181 ctctatcagc ggtaactact ggagctggat ccgccgggcc ccagggaatg gactggagtg
      241 gattggatat atctacggta gtgattttac caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagcagata cgtccaagaa ccagctctcc ctgaacctgg cctctgtgac
      361 cgccgcggac acggccgtct atttctgtgc cagtaatagt ataacatctg gtccagatta
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003357             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24490:12065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003357
VERSION     KCXD01003357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24490:12065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61839.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          110 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gtcgtctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003358             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22248:13108
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003358
VERSION     KCXD01003358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22248:13108"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61840.1"
                     /translation="CVTSSSGTWLYWYFDVW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          141 c          133 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag atttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggtg aaattataaa
      301 ttcagagagg ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgaaga cacggccgtg tattattgtg tgacctcatc
      421 cagcggcacc tggctatact ggtacttcga tgtctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003359             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:3814:10358
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003359
VERSION     KCXD01003359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:3814:10358"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61841.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       447..453
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          110 c          152 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctg
      121 ttttaagagg tgtccagtgc gaggtgcagc tggtggagtc tggaggagac ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aaatatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      301 atggaagtaa gacatactac gcaaactctg tgaaggaccg attcaccata ttaagagaca
      361 attccaagaa tatggtatat cttcaagtga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagacgat ttgggaagtg gctttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003360             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:5847:9381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003360
VERSION     KCXD01003360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:5847:9381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61842.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       436..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          112 c          150 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgcaatt
      121 ttaagaggtg tccagtgtga ggtgcagttg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagaaa ctatggcatg
      241 cactgggtcc gccaggcccc agggaagggg ctggattggg tggcagttat gtcgtttgat
      301 gaaaatgtga aattctacgc agactctgtg aaggaccgat tcagcatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccctgtat
      421 tactgtgcga gaggggaata cagtaactct attgacttct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003361             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15275:19074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003361
VERSION     KCXD01003361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15275:19074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61843.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          109 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agtaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatgtcat
      301 ctgatggaac taagaaattc tacgcagact ctgtgaaggt ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacagcct gaaatcggag gacacggccg
      421 tatattattg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003362             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9052:6588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003362
VERSION     KCXD01003362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9052:6588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61844.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          143 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccaa ctgatacagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaga ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagtctga gatctgaaga cacggccatg tattactgtg cgacatcacc
      421 cagcggcacc tggctatatt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003363             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15661:5033
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003363
VERSION     KCXD01003363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15661:5033"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61845.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       289..295
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           84 a           78 c          103 g           78 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgaagcctc
       61 tggattcacc ttcagtagtt atggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggagtgggtg gcagttatat cgtatgatgt aagtaagaaa tactacgcag acgctgtgaa
      181 ggaccgattc accatctcca gagacaattc caagaacaca ctatatcttc aaatgaacaa
      241 cctgaaattg gaggacacgg ccgtgtatta ctgtgggaga gatgataatg gggtgcttat
      301 cgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003364             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:16768:9667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003364
VERSION     KCXD01003364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:16768:9667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61846.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       449..457
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          114 c          158 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttcggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag gctctcctgt gcagcctctg gattcacctt cagtcactat
      241 ggcgttcact gggtccgcca ggctccaggg aaggggctgg actgggtggc agttatatcg
      301 tatgatgaaa ataagaaata ttacgcggac tttgtgaggg accgattcac cgtctccaga
      361 gacaattcca agaccatggt atatcttcag atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga tgtcagaggc ggtggctttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003365             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11097:20139
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003365
VERSION     KCXD01003365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11097:20139"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..359
     V_segment       142..298
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <290..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61847.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       301..306
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       317..359
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           90 a           81 c          105 g           85 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgggtggc agttacatcg tctgatgaaa gtaagaaata
      181 ctacgcagac tctgtgaagg cccgattcac cgtctccaga gacaattcca agaacatgtt
      241 atatcttcaa acggacaacc tgaaattgga agacacggcc gtgtattact gcgcgagaga
      301 tgtctggggg aggggatttg actattgggg ccagggagtc ctggtcaccg tctcctcagc
      361 c
//
LOCUS       KCXD01003366             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4704:6000
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003366
VERSION     KCXD01003366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4704:6000"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61848.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          102 a          126 c          157 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac aaaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta
      241 catgagctgg gtccgccagc ctccagggaa gggtctgggg tggatctcag gtattaacgc
      301 tggtggggat ggcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003367             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10597:9797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003367
VERSION     KCXD01003367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10597:9797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..477
     V_segment       108..401
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61849.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       416..428
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          136 c          137 g           96 t
ORIGIN      
        1 acatgggaca acacccctcc acagaagccc ctggatcaca gctccttgcc atggactgga
       61 cctggaggat cctcttcttg gtggcagcag caacaggtgc ccactcccag gtgcagctgg
      121 tgcagtcggg ggctgaggtg aagcagccgg ggacatcagt gaaggtctcc tgcaaggctt
      181 ctggctacac cttcactagc tatggtatga actgggtgcg acaggcccag ggacaacggc
      241 ttgagtggat gggatggctc aacaccgaca ctgggaaccc aacgtatgcc cagggcttca
      301 aagaacgatt tacattctcc atggacacct ctatgaccac ggcatatctg cagatcagca
      361 gcctaaagac tgaggacacg gccgtatact actgtgcaag aagtttgggc tggcatgatt
      421 ataatgacgt cgcccttgac ttctggggcc agggagtcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01003368             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23223:16823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003368
VERSION     KCXD01003368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23223:16823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61850.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          115 c          153 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaatacggtt tttctgcaaa tgaattccct gaaaatggag gacacggccg
      421 tgtattactg tgtgagagtc catgactacg ctatgtacta ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003369             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11489:17948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003369
VERSION     KCXD01003369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11489:17948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61851.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       263..269
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           74 a           82 c           88 g           76 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
       61 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      121 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatggtg tatcttcaaa tgaacaacct gacatttgag gacgcggccg
      241 tgtattactg tgcgagagat tcttacggtc gaggctttga ttcctggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003370             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23410:11772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003370
VERSION     KCXD01003370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23410:11772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61852.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          137 c          131 g          108 t
ORIGIN      
        1 acatgggggg atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003371             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17194:11607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003371
VERSION     KCXD01003371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17194:11607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61853.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          118 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccatt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catgcactgg gtccgccagg ctccagggaa gggtctggag tgggtggcag ttatgtcgca
      301 tgatggaact aagaaattct acgcagactc tgtgaaggac cgattcacca tctccaggga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg agattggagg acgcggccgt
      421 ctattattgt gcgagaggag actacggtaa cagccttgac ttctggggcc agggagtcct
      481 gctcaccgtc tcctcagcc
//
LOCUS       KCXD01003372             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:26691:8148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003372
VERSION     KCXD01003372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:26691:8148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61854.1"
                     /translation="CATSSSGTWLYWSFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          124 a          142 c          135 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacatct taaccgaatt atccatacac tgggtgcgac
      241 aggccgctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 aagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagt ctgagatctg acgacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtcct tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01003373             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10940:10036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003373
VERSION     KCXD01003373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10940:10036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61855.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          112 c          156 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaactaagaa atactacgca gactctgtga aggcccgatt caccgtctcc aaagacaatt
      361 ccaagaacat gttatatctt caaatggaca acctgaaatt ggaagacacg gccgtgtatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003374             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22817:7519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003374
VERSION     KCXD01003374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22817:7519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..472
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61856.1"
                     /translation="CARGRIHLQFMDSW"
     D_segment       421..428
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          108 a          131 c          138 g           97 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagcg catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgt
      181 aaggcttctg gatacacctt caacatgttt gccatcaatt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agggaacatc cctcttgttg atataacaaa gtacgcacag
      301 aagttccagg acagagtcac atttaccgcg gacacgtcca ctagcacagc ctacatggag
      361 ctgagcagcc tgagatctga ggacacggcc gtttattact gtgcgagagg gaggattcac
      421 ctacagttca tggactcctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003375             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18571:15522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003375
VERSION     KCXD01003375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18571:15522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61857.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          126 c          157 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac aaaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta
      241 catgagctgg gtccgccagc ctccagggaa gggtctggag tggatcgcag gtattaacgc
      301 tggtggggat ggcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003376             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24936:5880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003376
VERSION     KCXD01003376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24936:5880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..452
     V_segment       100..377
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61858.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       391..397
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..452
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT          115 a          127 c          124 g           88 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagtctgggg ctgaggtgaa
      121 gaagcctggg gcctcagtga aggtctcctg caaggtttcc ggatacatct taaccgaatt
      181 atccatacac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaagtgttga
      241 tcctcaatat ggtgaaatga tagacgcaga gaaagtccaa ggcagagtca ccatgaccga
      301 ggacacgtct acagacacag cctacatgga gctgagcagt ctgagatctg aggacacggc
      361 cgtgtattac tgtgcgacat cgtccagcgg cacctggcta tactggtact tcgatatctg
      421 gggccctggc accccaatca ccatctcgtc agcc
//
LOCUS       KCXD01003377             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18596:11549
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003377
VERSION     KCXD01003377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18596:11549"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61859.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          111 c          155 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gaagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgtaa gtaagaaata ctacgcagac gctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgggagaga tgataatggg gtgcttatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003378             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9009:4676
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003378
VERSION     KCXD01003378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9009:4676"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61860.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          138 c          152 g          103 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg ccctctctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaggaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga tttatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggt tgggaggtgt tgatcctgca aatggtgagg taatacacgc
      301 agatagtttt cagggcagag tcaccatgac cgaggacacg tctacactca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gagggcggtt
      421 cggtagcagc gtctggtcca atctcgtcta tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003379             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14195:7674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003379
VERSION     KCXD01003379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14195:7674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..482
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61861.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       406..431
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           95 a          141 c          132 g          116 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agttgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgtctccatc agcagtcact actggagctg gatccgccag tccccaggga aggggctgga
      241 ttggattggc tttatctatg gtggtgatgg gtacaccacc tccaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tccctaaacc tgaggtctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat ccgcgttacg aggatgatca
      421 cggttactat tctgtggaaa ttgactactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01003380             305 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11148:2687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003380
VERSION     KCXD01003380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 305)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 305)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11148:2687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    31..303
                     /note="immunoglobulin heavy chain variable region"
     V_region        31..303
     V_segment       31..228
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <222..>272
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61862.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       239..251
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       254..303
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        304..>305
                     /gene="IGHG"
BASE COUNT           76 a           86 c           86 g           57 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctcaccga agtgtccact cactgggtgc
       61 gacaggctcc cggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa
      121 tgaagttcca gggcagagtc accatgaccg aggacacgtc cacagacaca gcctacatgg
      181 aattgagcag cctaagatct gaggacacgg ccgtgtatta ctgtgcgatt ggacctaccg
      241 gcaggtggaa cggctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct
      301 cagcc
//
LOCUS       KCXD01003381             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17739:20557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003381
VERSION     KCXD01003381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17739:20557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61863.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          105 a          128 c          154 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttaatggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacgct
      301 ggtggggata ccacatactc tgcagactcc gtgaagggca gatccaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gacctgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003382             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:26150:9786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003382
VERSION     KCXD01003382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:26150:9786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61864.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          142 c          136 g          101 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccaggaaagg ggctggagtg
      241 gattgggttt ttcggtggtt atggtgggag cacctactac aacccctccc tccagagtcg
      301 agtcaccatt tcagccgaca cgtccaaaca ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctcc actattgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003383             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15794:13529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003383
VERSION     KCXD01003383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15794:13529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61865.1"
                     /translation="CATGRIGSSGWSNLFTGLESW"
     D_segment       428..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          147 c          143 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggat ttgttgatcc tgtcaatggt gaagaaattc
      301 acgcagagaa attccagggc agagtcacct tgaccgagga cacgtccaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtag cagcggctgg tccaacctct tcaccggttt ggaatcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003384             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:3116:11902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003384
VERSION     KCXD01003384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:3116:11902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61866.1"
                     /translation="CARGIDNYHFSDTDFDYW"
     D_segment       451..458
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          117 a          113 c          149 g          129 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg tggagcagtt ggtggaatct gggggaggat tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagta gctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctggagtgg gtatcaggta ttaacattgg
      301 cggtgacaca tactacccag actctgtgaa gggtcgattc actatctcca gagacaatgc
      361 caagaactcc gtgtatcttc aaataaacag cctgagagtt gaggacactg ctgtgtattt
      421 ttgtgcaagg gggatagata actaccactt tagtgatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003385             359 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:7876:10782
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003385
VERSION     KCXD01003385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 359)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:7876:10782"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..357
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..357
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>326
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61867.1"
                     /translation="CARTDCTGGVCYFDYW"
     D_segment       301..314
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..357
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        358..>359
                     /gene="IGHG"
BASE COUNT           81 a           84 c          108 g           86 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agccgggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agtagttatg gcatggactg ggtccgccag gctccaggga
      121 aggggctgga atgggtggca gttatatcgt ttgatggaag taagaaatac tacgcagact
      181 ctatgaagga ccgattcacc ctctccagag acaattccaa gaacatgcta tatcttcaaa
      241 tgagcaacct gaaattggag gacacggccg tctattactg tgcgagaacg gattgtactg
      301 gtggtgtctg ctactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003386             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8940:10960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003386
VERSION     KCXD01003386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8940:10960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61868.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          147 c          147 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtttgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg gaaagggctt gagtggatgg gagttgttga tcctgccaat ggtgaagaaa
      301 tacacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga cttgaccagt ctcagatctg aggacacggc catctattac tgtgcgacag
      421 ggaggatcgg tagcagcgcc tggtccaacc tcttcaccgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003387             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12497:9101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003387
VERSION     KCXD01003387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12497:9101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61869.1"
                     /translation="CARDRLGGGWFDYW"
     D_segment       408..419
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           92 a          134 c          136 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tacaggagtc
      121 gggcccagga gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc gatagttaca ggtggagctg gatccgtcag cccccaggga aggaactgga
      241 gtggataggg tacatctatg gtggtaatac gggcaccaac tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaaaag acacgtccac gaaccagttc tccttgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattcctg tgcgagagat cggcttggcg gtggctggtt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003388             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19514:6823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003388
VERSION     KCXD01003388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19514:6823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..476
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61870.1"
                     /translation="CATGPSGTWNAWYLDMW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>480
                     /gene="IGHG"
BASE COUNT          111 a          144 c          133 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 actagcctga catctgagga cacggccgtg tattactgtg cgactggccc tagcggcacc
      421 tggaacgcct ggtacctcga tatgtggggc cctggcaccc caatcaccat ctcctctgcc
//
LOCUS       KCXD01003389             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23272:12248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003389
VERSION     KCXD01003389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23272:12248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..504
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61871.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       450..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>508
                     /gene="IGHG"
BASE COUNT          104 a          128 c          157 g          119 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagga acactggtaa
      301 aatcgtatac tacgctgact ccgtgaaggg ccgattcacc atttccagag acaacaccaa
      361 gaactcgctg tctctgcgaa tgagcagcct gagagccgag gacacggccg tgtactactg
      421 tactagaatt ggcgtcggat ctctggcaac ggctggtgac tactttgacc actggggcca
      481 gggagtcctg gtcaccgtct cctccgcc
//
LOCUS       KCXD01003390             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20514:19236
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003390
VERSION     KCXD01003390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20514:19236"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61872.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       427..433
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..487
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          106 a          117 c          149 g          117 t
ORIGIN      
        1 acatggggag ccccagaatt cccaggtgtt tctgttcggc gatcagcaca aaacacagaa
       61 cataccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa aggtgtccag
      121 tgtgaggtga agctggtgga gtctgggggc ggcttggcaa agcctggggg gtccctgaga
      181 ctctcctgcg cagcctctgg attcagcttc agttattact acatgagctg ggtccgccag
      241 gctccaggga aggggctgga gtggatctca ggtgttaata gtggtgggga aagcacatac
      301 tctgcagact ccgtgaaggg cagattcacc atctccagag agaacgccaa gaacacacta
      361 tatcttcaaa tggacagcct gagaactgag gacacggctg tctattactg tgtgagagat
      421 cgacgtgtac agtcgttatc ctggttcgat gtctggggcc cgggagccct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01003391             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10986:13939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003391
VERSION     KCXD01003391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10986:13939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61873.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       437..448
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          111 a          116 c          152 g          117 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccattgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactgt cctgtgcagc ctctggattc accttcatta actatggcat
      241 gcactgggtc cgccaggctc cagggaaggg tctggagtgg gtggcagtta tgtcgcatga
      301 tggaactaag aaattctacg cagactctgt gaaggaccga ttcaccatct ccagggacaa
      361 ttccaagaac atggtatatc ttcaaatgaa caacctgaga ttggaggacg cggccgtgta
      421 ttactgtgcg agaggagact acggtaacag ccttgactac tggggccagg gagtcctgct
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01003392             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15693:5948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003392
VERSION     KCXD01003392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15693:5948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61874.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          133 c          135 g          103 t
ORIGIN      
        1 acatggaggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagg tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003393             359 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23320:17430
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003393
VERSION     KCXD01003393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 359)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23320:17430"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..357
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..357
     V_segment       8..279
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <273..>326
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61875.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       288..298
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       308..357
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        358..>359
                     /gene="IGHG"
BASE COUNT           75 a          106 c          103 g           75 t
ORIGIN      
        1 acatgggggg cccaggactg ctgaagcctt tggagaccct gtccctcacc tgcgctgtct
       61 ctggtggctc catcagcagt aactactgga gctggatccg ccagtcccca gggaagggac
      121 tggagtggat tggacgtatc tctggtagtg gtgggaacac cgtctacaac ccctccctca
      181 agagtcgagt caccatttca acagacacgt ccaagaacca gatctccctg aaagtgacct
      241 ctgtgaccgc cgcggacacg gccgtgtatt attgtgcgac agccggatat agcagcaggg
      301 aaagcttcta cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003394             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:7847:11505
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003394
VERSION     KCXD01003394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:7847:11505"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61876.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       415..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          137 c          139 g          108 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctgatgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctttg ccatcaattg ggtgcgacag gcccctggac
      241 aagggcttga ttggatggga gggatcatcc ctcttgttgg gataacaaac tacgtgcaga
      301 agttccaggg cagagtcacc attaccgcgg acacgtccac aagtatagcc tacatggagc
      361 tgagcggcct aagatctgag gacacggccg tgtattactg ttcgagaggg tcaaattacg
      421 aggatgcttc cgattacttt tccgcctttg actcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01003395             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8571:6406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003395
VERSION     KCXD01003395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8571:6406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61877.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       451..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          105 a          127 c          157 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttaatgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctggc gtggatctca ggtattaacg
      301 ctggtgggga taccacatac tatgcagact ccgtgaaggg cagatccacc atctccagag
      361 agaacgccag gaacacactg catcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003396             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:11632:12042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003396
VERSION     KCXD01003396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:11632:12042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61878.1"
                     /translation="CARELYNSGWADAFDFW"
     D_segment       438..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          108 a          110 c          167 g          122 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggagggtt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca tcttcagtag ctttggcatg
      241 cactgggtcc gccaggctcc agggaggggg ctggagtggg tggcgggtat gtcgtatgat
      301 gggagtgaga aagactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga gagagttgta taacagcggc tgggctgatg cttttgattt ctggggccga
      481 gggctcaggg tcaccgtctc ttcagcc
//
LOCUS       KCXD01003397             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10195:4210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003397
VERSION     KCXD01003397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10195:4210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61879.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       438..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          120 c          151 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttcc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctggggag tccctgagac tctcctgtgt agcctctgga ttcacgttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgtctg tactttcgtc
      301 tgatggaagt aacaaatact acgcagactc tatgaaggac cgattcacca tctccagaga
      361 caactccaag aacacactat atcttcaaat gaataacctg aaactggagg acacggccgt
      421 gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003398             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:10501:15123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003398
VERSION     KCXD01003398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:10501:15123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..494
     V_segment       137..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61880.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       435..440
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..494
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          116 a          112 c          150 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gaccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacg ttcagtaact atggaatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtacgatga
      301 agataagaaa tactacgcag actctctgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctttatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtttatta
      421 ctgtgcgagg aggccctgga gtgcagatgc ttttgatttc tggggccaag gactcagggt
      481 caccgtctct tcagcc
//
LOCUS       KCXD01003399             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7762:14747
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003399
VERSION     KCXD01003399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7762:14747"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61881.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          111 c          153 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatttctt caaatggaca acctgaagtt ggaggacacg gccgtctatt
      421 attgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003400             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22943:2112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003400
VERSION     KCXD01003400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22943:2112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61882.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          122 a          140 c          137 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agggttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aagtccaagg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatcg
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcgtcag cc
//
LOCUS       KCXD01003401             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13149:3418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003401
VERSION     KCXD01003401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13149:3418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..446
     V_segment       83..382
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61883.1"
                     /translation="CARRIRGGWPYFDFW"
     D_segment       392..396
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           97 a          138 c          113 g          100 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tccacgctcc tgctgctgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcgc cgtctctggg ttctcactca acaatattgg
      181 tatgggggtg ggctggatcc gtcagccctc aggaaagacc ctggagtggc ttgcacacat
      241 ttactgggat gataacaagc tctacagcac atctctaaag aacagactca ccatctccag
      301 ggacacctcc aaaaacctgg tacttctgac aatgaccaac atggaccctg cggacacagc
      361 cacatatttc tgtgcacgaa gaattagggg cggttggccg tattttgact tctggggcca
      421 gggagtcctg gtcaccatct cctcagcc
//
LOCUS       KCXD01003402             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20816:3197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003402
VERSION     KCXD01003402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20816:3197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61884.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          102 a          123 c          161 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagccgg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag tttcagtcac tacttcatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcagggatt aacagtggtg
      301 gggatactac ataccacgca gactccgtga agggcagatt caccatgtcc agagagaacg
      361 ccaagaacac actgtctctt caaatggacg gcctgagagc tgaggactcg gctgtctatt
      421 actgtgcgag agatcgacgt gtacagtcgt tatcttggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003403             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:7055:12791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003403
VERSION     KCXD01003403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:7055:12791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..438
     V_segment       84..363
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61885.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       371..386
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..438
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           92 a          119 c          136 g           93 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaggtcc ttctggtgca gtctggggct gaggtgatgc
      121 agcctggggc ctcagtgaag gtctcctgca aggtttccgg atacaccttc accgaattgt
      181 ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtgggtggga agtgttgatc
      241 ctgcatatgg tgaaatggtg ttccagggca gagtcaccat gaccgaggac acgtctatag
      301 acacagccta catggagttg agcagcctga gatctgagga catggccgtg tattactgcg
      361 cgattggccc tagcggcaac tggaacggct ggtccttcga tatctgggga cctggcaccc
      421 caatcaccat ctcctcagcc
//
LOCUS       KCXD01003404             382 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9775:11057
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003404
VERSION     KCXD01003404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 382)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 382)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9775:11057"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..380
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..380
     V_segment       20..313
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>349
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61886.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       314..318
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       334..380
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        381..>382
                     /gene="IGHG"
BASE COUNT           78 a           95 c          127 g           82 t
ORIGIN      
        1 acatgggggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
       61 tggggggtcc ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat
      121 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttgacagtgg
      181 tggggatagc acatactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa
      241 cgccaagaac acactgtatc ttcaattgga cagcctgaga gctgaggaca cggctgtcta
      301 ttactgtgcg agagtggtgg gtggtgccgc aggatacttc gacttctggg gccagggcgc
      361 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003405             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15067:7574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003405
VERSION     KCXD01003405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15067:7574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61887.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       422..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          113 a          140 c          137 g          101 t
ORIGIN      
        1 acatggggca tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggttca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acgcagaaaa gttccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagcctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcaa ttggcttttt tggtacttcg atttttgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01003406             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16617:20570
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003406
VERSION     KCXD01003406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16617:20570"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61888.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       432..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          114 a          141 c          153 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtaa
      181 aggtctcctg ccaggtttcc ggatacacct tcagtgaaat gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgttgc tcctggaaat ggtgaaataa
      301 tacacgcaga gagcttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtagc ctgagatctg aggacacggc cgtgtattac tgtgcgacag
      421 ggaggttcgg gagcagcgtc tggtccagcc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003407             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15563:17816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003407
VERSION     KCXD01003407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15563:17816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61889.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcct
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcccc atctccagag
      361 acaattccaa aaacatgata tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattattg tgtgagagat gtcaggggaa cggggtttga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003408             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21594:16874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003408
VERSION     KCXD01003408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21594:16874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61890.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          140 c          154 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggggttgatc ctgcaaatgg tgaggtaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 cggttcggta gcagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003409             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:27320:16411
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003409
VERSION     KCXD01003409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:27320:16411"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..481
     V_segment       100..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61891.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       398..402
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           97 a          144 c          135 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag aacagacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccttcagca cttcctactg gagctggatc cgccaggccc cagggaaggg actggagtgg
      241 attggatata tctatgctga tagtgggacc accagctaca acccgtccct caagagtcga
      301 gtcaccattt caatagacac gtccaagaat ctgtactccc tgaaactgag ctctgtgacc
      361 gccgcggaca cggcctttta ttactgtgcg agacgtccta ctcgcacgcg ggttctatat
      421 gaggcgacag gggaagactt tgactcctgg ggccagggac tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01003410             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:27494:13181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003410
VERSION     KCXD01003410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:27494:13181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..460
     V_segment       106..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61892.1"
                     /translation="CGNGARRTLGDYW"
     D_segment       395..399
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          138 c          140 g          102 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcacg gacctcctgt gcacgaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggtagctccc agatgggtcc tgtcccagat gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg cggtgtctct
      181 ggtggctcca tcagcggtta ctggtggggc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtatatcgg tggtactagt gggagcacct tctacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccagt tctccctgat gctgacctct
      361 gtgaccgccg cggacacggc cgtctatttt tgtggtaacg gggcccgacg tactttgggg
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003411             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5425:16665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003411
VERSION     KCXD01003411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5425:16665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61893.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       419..427
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          118 a          141 c          133 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ccccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaactaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggccg aagtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga cacacctaca ccgaagtatc cattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgctcc tatatatggt gaaatactaa
      301 acacagacaa gttccagggc agagtcacca tgaccgagga cacgtctgca gacacagcct
      361 acatggagtt gagcagcctg agatctgagg acacggccgt atattactgt gtggcggctg
      421 atagtggtta ccctttttac tacttcgata tctggggccc tggcacccca atcagcatct
      481 cctcagcc
//
LOCUS       KCXD01003412             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16649:10228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003412
VERSION     KCXD01003412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16649:10228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..458
     V_segment       92..383
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61894.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       396..405
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT          104 a          117 c          145 g           94 t
ORIGIN      
        1 acatgggaga agccccagag catagcacct caccatggac tggacctgga ggatcctcct
       61 cttggtggca gcagctacag gcgcccactc tgaggtccag ttggtgcagt ctggggctga
      121 ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag gtttccggat acaccttcac
      181 cgatttatcc atgcactggg tgcgacaggc cccaggaaaa gggcttgagt ggatgggaag
      241 tgttgatcct gtatatggtg aaataattgt cgcagagaat ttccaggaca gagtcaccat
      301 gaccgaggac acgtctacag acacagccta catggagctg agcagcctgg aatctgagga
      361 cacggccgtg tattactgtg cgaaagggag gagtggtggt gtctggccga gctccttcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003413             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13352:10562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003413
VERSION     KCXD01003413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13352:10562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61895.1"
                     /translation="CVRRPFGSDAFDFW"
     D_segment       441..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          112 c          149 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaaatttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgcatgatg
      301 aaaataagaa atactacgta gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgcaatt ggaggacacg gccgtgtatt
      421 attgtgtgag acgaccgttc ggtagtgatg cttttgattt ctggggccaa gggctcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01003414             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17877:18425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003414
VERSION     KCXD01003414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17877:18425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61896.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          117 c          151 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttcctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtctgtaatt tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacac actatatttt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003415             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13674:4736
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003415
VERSION     KCXD01003415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13674:4736"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..488
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61897.1"
                     /translation="CANGMSGLDYW"
     D_segment       433..437
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          100 a          124 c          154 g          112 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtcgctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag gtattactag
      301 tggtggtaac acatacttcg cagactccgt gaagggccga ttcaccctct ccagagacga
      361 ctcaaagaac acagtctcct tgcaaatgaa cagtctgaga cctgaggaca cggccgtgta
      421 ttactgtgcg aatgggatgt cagggcttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003416             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15702:10227
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003416
VERSION     KCXD01003416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15702:10227"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61898.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       419..434
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          102 a          143 c          127 g          106 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt tcttcatttc tgtcctccac
       61 cacgatgggg tcaactgcca tcctcgccct cctcctggct gttctccaag gagtctgtgc
      121 cgaggtgaaa ctggtgcagt ctggggcaga ggtgagaagg cccggggagt ctctgaagat
      181 ctcctgtaag acttctggat acagctttac caccaactgg atcagttggg tgcgccagac
      241 gcccggaaaa ggcctggaat ggatggggac catctatcct gctgattctg aggccaaata
      301 caacccgtcc ttccaaggcc acgtcactat ctcagccgac aagtccatca gtaccaccta
      361 cctgcagtgg agcagcctga aggcctcgga caccgccacg tatttctgtg cgaaaaccta
      421 ctatagtggt agtttggaaa tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003417             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:21765:17197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003417
VERSION     KCXD01003417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:21765:17197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..328
     V_segment       5..255
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <247..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61899.1"
                     /translation="CARDRDTRSGYYGLDSW"
     D_segment       269..277
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..328
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           80 a           83 c           93 g           74 t
ORIGIN      
        1 acatgggggt ccctgagact ctcctgtgca gcctctggac tcaccttcag tacctctggc
       61 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtat
      121 gatggaagta agaaatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      181 aattccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccgta
      241 tattactgtg cgagagatag ggatacacgc agcggctatt acggtttgga ttcctggggc
      301 cgaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003418             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:23608:12680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003418
VERSION     KCXD01003418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:23608:12680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    149..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        149..512
     V_segment       149..440
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <434..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61900.1"
                     /translation="CARAGRYTHSYPFDYW"
     D_segment       452..462
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          104 a          158 c          133 g          119 t
ORIGIN      
        1 acatggggct ccctcaccac ccagctgggg atctcagtgc ttcattttct gtccttcatt
       61 tctcagtgct tgatttctgt cctccaccac gatggggtca actgccatcc tcgccctcct
      121 cctggctgtt ctccaaggag tctgtgccga ggtgcaactg gtgcagtctg gagcagaggt
      181 gaaaaggccc ggggaatctc tgaggatctc ctgtaagact tctggataca gcttcaccaa
      241 ttactggatc agttgggtgc gccagatgcc cgggaaaggc ctggagtgga tgggaatgat
      301 ctatcctagt gattctgatc ccagatacag cccgtccttc caaggccagg tcaccatctc
      361 agccgacaag tccatcagca ccgcctacct gcagtggagc agcctaaagg cctcggacac
      421 cgccacgtat tactgtgcga gagctggacg atacacccac agttacccct ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003419             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13524:13663
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003419
VERSION     KCXD01003419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13524:13663"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61901.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          114 a          143 c          130 g           92 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca agcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggt aaagtagact
      301 acacacagaa gttccgagac agagtcacca tcaccgcgga catgtcgaca gagacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac ttctggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003420             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6841:11408
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003420
VERSION     KCXD01003420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6841:11408"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61902.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          115 c          150 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaagtttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaagct ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatctgcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatcttggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003421             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5940:10185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003421
VERSION     KCXD01003421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5940:10185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61903.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          114 c          156 g          125 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggttcctg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaag tagcatatac tacgcagcct ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaagtttgag gacacggccg
      421 tgtattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003422             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12651:21675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003422
VERSION     KCXD01003422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12651:21675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..280
     V_segment       8..206
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61904.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       209..222
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..280
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>284
                     /gene="IGHG"
BASE COUNT           65 a           68 c           89 g           62 t
ORIGIN      
        1 acatgggatc catgcattgg gtgcgacagg cccctggaaa agggcttgag tggatgggag
       61 gtgttgatcc tgcatctggt gaaatcatat acgcagagaa gttccagggc agagtcacca
      121 tgaccgagga cacgcctaca gacacagcct acatggagtt gagcagcctg agatctgagg
      181 acacggccgt gtattactgt gcgagaggat attgtagtgg tagtcactgc tcctccggat
      241 ttgactactg gggccaggga gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01003423             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:6441:17253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003423
VERSION     KCXD01003423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:6441:17253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..498
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61905.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>504
                     /gene="IGHG"
BASE COUNT          118 a          145 c          144 g           97 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgatttat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga gttgttaatc ctgtaaatgg agaaatgata
      301 cacgcagaga agttccaggc cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tggtcagcct gacatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcgtctg gtccagcctc ttcaacggct tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctccgc agcc
//
LOCUS       KCXD01003424             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7131:4611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003424
VERSION     KCXD01003424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7131:4611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..336
     V_segment       8..260
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <252..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61906.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       272..282
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           69 a           97 c           99 g           73 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc accagtagta
       61 attggtggag ctggatccgc cagtccccag ggaagggact ggaatggatt gggggtatct
      121 atggtagtgg tgggaatacc gaatacaacc cctccctcaa gagtcgagtc accatttcaa
      181 aggacacgtc caagaaccag ttctccctga agctgaactc tgtgaccgcc gcggacaccg
      241 ccgtgtatta ctgtacgaga gaatggggcg ctatagcggc agttgggcct gtccttgcct
      301 cctggggcca gggtgtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003425             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15084:12838
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003425
VERSION     KCXD01003425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15084:12838"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..451
     V_segment       94..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61907.1"
                     /translation="CAREGISASGVDYW"
     D_segment       390..396
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           81 a          133 c          143 g           96 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg tagctcccag atgggtcctg tcccaggtgc aacttcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga gtggattggg
      241 tttttcggtg gtcgcaatgg gaacacctac tacaacccct ccctcaagag tcgagtcacc
      301 atttcaccag acacgtccaa agaccagttc tccctgaggc tgaggtctgt gaccgccgcg
      361 gacacggccg tgtattactg tgcgagggag gggatatcag cgtcgggggt cgactactgg
      421 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003426             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5822:7064
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003426
VERSION     KCXD01003426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5822:7064"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    86..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        86..466
     V_segment       86..377
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61908.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       386..410
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>472
                     /gene="IGHG"
BASE COUNT          104 a          124 c          142 g          102 t
ORIGIN      
        1 acatgggggg ggaacacagc tcatcaccat ggacttgacc tggaggctcc tctttgtggt
       61 ggcagcagct acaggtgccc agtcccaggt ccacctggtg cagtccgggg ctgaggtgaa
      121 gaagcctggg gcctcagtga agctctcctg caaggcttct ggatacacct tcagcatctc
      181 ttccatcagt tgggtgcgac aggcccctgg acaagggctt gggtggatag gagggatcat
      241 ccctcttgtt ggtatgacaa actacgaaca gaagttccag ggcagagtca cgattaccgc
      301 ggacacgtcc acgaaaacag tcttcatgga actgagcagc ctgagatctg aggacacggc
      361 cgtctactat tgtgcgacag gggtatatta ccaggatgaa aacggttact tttatgtcgg
      421 cggtgacttt gactactggg gccagggagt cctggtcacc gtctccccag cc
//
LOCUS       KCXD01003427             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:10912:7333
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003427
VERSION     KCXD01003427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:10912:7333"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..348
     V_segment       8..285
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61909.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       292..304
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           67 a          104 c          102 g           77 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg
       61 ctgtctctgg tgactcaatc agcagttact tctggaactg gatccgccag gccccaggga
      121 agggactgga gtggattggg tttctctatg gtagtgatag tacctccaac tacaatccct
      181 ccctcaagag tcgagtcacc ctgtctgtgg acacgtccaa caaccaggtc tccctgatgc
      241 tgaactctgt gaccgccgcg gacacggccg tctattactg tgcgaccggg aagcggcagc
      301 tggatcttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003428             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10990:7994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003428
VERSION     KCXD01003428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10990:7994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61910.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          155 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaac taagaagtac tacggagact ctgtgaaaga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tatattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01003429             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6273:15011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003429
VERSION     KCXD01003429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6273:15011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61911.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       426..441
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           98 a          143 c          135 g          113 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa tgctctctga gagtcatgga cctcctgtgc
       61 aagaacatga agcacctgtg gttcttcctt ctcctggtga cagctcccag atgggtcctg
      121 tcccaggtgc agctgcagga gtcgggccca ggactggtga agccttcgga aaccctgtcc
      181 ctcacctgcg ctgtctctgg tggctccatc agtagtagct tctggacctg gatccgtcag
      241 cccccaggga agggcctgga atggattggc tttatctatg gtgccactgg gagcaccggc
      301 tacagcccct ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccagttt
      361 tccctgaggc tgacctctgt gaccgccgcg gacaccgccg tttattattg tgcgagatat
      421 gaggatgaat acagtgacta ctactttgac tactggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01003430             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24601:14482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003430
VERSION     KCXD01003430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24601:14482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61912.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          140 c          151 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagagc ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003431             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12453:8815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003431
VERSION     KCXD01003431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12453:8815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61913.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          111 c          154 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcattc
      241 actgggtccg ccagactcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01003432             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11581:7301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003432
VERSION     KCXD01003432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11581:7301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61914.1"
                     /translation="CAKRGGHGTTTTLFFFDYW"
     D_segment       429..434
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          143 c          139 g          104 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgatgaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccctcagc atctctgcca tcagttgggt tcgacaggcc
      241 cctggacaag gacttgagtg gatgggagag atcttccctc ttgttggtat gacaaaatac
      301 gcacagaact tccagggcag agtcacgatt accgcggaca cgtccacagg tacagcctac
      361 atggagctga gcggcctgag ttctgaggac acggccgtat attactgtgc gaaaagaggt
      421 ggccacggta ccaccaccac gttgttcttc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003433             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:24491:11045
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003433
VERSION     KCXD01003433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:24491:11045"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61915.1"
                     /translation="CARGDCSGGVCFFDYW"
     D_segment       444..462
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          113 a          113 c          155 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga atctggagga ggcctggttc
      181 agcctggggg gtccttgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
      241 gcatgaactg ggtccgccag gctccaggga agggactgga ttgggtgtca attatatcgt
      301 ttgatggaac taagaaatac tacgcagact ctgtgaagga ccggttcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gactgtagtg gtggtgtctg cttttttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003434             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:23775:9463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003434
VERSION     KCXD01003434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:23775:9463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61916.1"
                     /translation="CTTWTTGYNYYFAYFDSW"
     D_segment       417..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           96 a          142 c          132 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gagcggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatca gcgacactaa caggtggagt tggatccgcc agtccccagg gaagggactg
      241 gagtggattg gatacatcga tggcacttct acgcgcaccg actacacccc ctccctcaaa
      301 ggtcgagtca ccatttcaaa agacacgtcc aggaaccagt tctccttgag gctgaattct
      361 gtgagcgccg cagacacggc cgtgtattac tgtacgactt ggacgactgg gtataattat
      421 tacttcgcct actttgacag ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003435             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12194:18314
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003435
VERSION     KCXD01003435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12194:18314"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..256
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <248..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61917.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       262..269
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..326
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           73 a           92 c           87 g           76 t
ORIGIN      
        1 acatgggggg ggatccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
       61 tgctatgcat tgggtccgcc aggctccagg gaaggggctg aaatgggtct catctattag
      121 tagtggtggt ctcacatact acgcagactc cgtgaagggc cgatttgcca tctccagaga
      181 caactcaaag aacacgctct ccctgcaaat gaacagcctg agcgctgagg acacggccgt
      241 atattactgt gcgaaaggag gtagcagctc tttctattgg tacttcgata tctggggccc
      301 tggcacccca gtgaccatct cctcagcc
//
LOCUS       KCXD01003436             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10450:20486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003436
VERSION     KCXD01003436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10450:20486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61918.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       439..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          115 c          145 g          122 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccggtg tgaggtgcaa ctggtggagt ctggaggagg cttggttcaa
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taactttggc
      241 atacactggg tccgccaggc tccagggaag gggctggagt gggtgacagt tatttcgtct
      301 gatggaacta acaaatacta cgcaaactct gtgaagagcc gattcaccat ctccagagac
      361 aattccaaga acatactata tcttcaaatg aacaacttga aattggagga cacggccgtc
      421 tattactgtg cgagagatga tattgggacc ggttttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003437             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12330:10121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003437
VERSION     KCXD01003437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12330:10121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61919.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       438..443
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          122 c          161 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcacagcctc tggattcagt ttcagatact actacatgac
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcagggatta acagtggtgg
      301 ggataacaca gaccatgcag actccgtgaa gggcagattc accatctcca gagaggacgc
      361 cgagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gttgtgggtg gtgccgcagg gtacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003438             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15426:15507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003438
VERSION     KCXD01003438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15426:15507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..282
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..282
     V_segment       8..217
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <210..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61920.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       224..233
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       241..282
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        283..>284
                     /gene="IGHG"
BASE COUNT           56 a           83 c           84 g           61 t
ORIGIN      
        1 acatgggcat cagcggttac tggtggggct ggatccgcca gtccccaggg aaggggctgg
       61 agtggattgg gtttttcggt ggtagtggtg ggagcaccta ctacaaatcc tccctccaga
      121 gtcgcgtcac catttcaacc gacacgtcca agaaccagtt ctccctaata ctgacctctg
      181 tgaccgccgc ggacacggcc ctctattact gtgcgagggg gaatatagca gcgactggca
      241 ttgactactg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003439             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24114:3927
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003439
VERSION     KCXD01003439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24114:3927"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61921.1"
                     /translation="CAKTDYSGSLVYW"
     D_segment       422..431
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          101 a          142 c          131 g          106 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gtgcttcatt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcgcc ctcctcctgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggacca gaattgaaaa ggcccgggga gtctctgagg
      181 atatcctgtg agacttctgg atacagcttt accagcaggt ggatcagctg ggtgcgccag
      241 atgcccggga aagacctgga gtggatgggg accatctatc ctggtgattc tgagaccaaa
      301 tacaacccgt ccttccaagg ccacgtcact atctctgccg acaagtccat cagcaccacc
      361 tatctacagt ggagcagtct caaggcctcg gacaccgcca cgtacttctg tgcgaaaacc
      421 gactatagtg gaagtttggt ctactgggga cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003440             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22469:20024
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003440
VERSION     KCXD01003440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22469:20024"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61922.1"
                     /translation="CTRGIDNYHFSNTDFDFW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          117 c          145 g          131 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggaatctg ggggaggctt ggtacaacct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tttccggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaacgcc
      361 aagaactcct tgtatcttct aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtacaaggg ggatagataa ctaccacttt agtaatacgg actttgactt ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003441             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:25243:5754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003441
VERSION     KCXD01003441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:25243:5754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61923.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          134 c          147 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacgtactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaagg gcagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003442             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15413:11140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003442
VERSION     KCXD01003442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15413:11140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61924.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          140 c          134 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgagggc acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003443             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17114:16191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003443
VERSION     KCXD01003443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17114:16191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61925.1"
                     /translation="CARYEADGTSYYFDYW"
     D_segment       408..413
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           86 a          139 c          129 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggtcct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccgtcgtc aatagcttct ggagctggtt ccgcctgcct ctagggaagg gactggagtg
      241 gattggctat atctatggtg cgactgggag caccacctac aacccctccc tcaagagtcg
      301 agccaccatt tccatagaca cgtccaagaa tcagttttcc ctgaagctga cctctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgaa gctgatggta cttcttacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003444             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:25783:8843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003444
VERSION     KCXD01003444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:25783:8843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61926.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          144 c          149 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat gggctggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggag cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgactt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gagttgttga tcctgtaaat ggtgaaatga
      301 tacacgcaga gatgttccag gccagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgagatctg aggacacggc catctattac tgtgcgacag
      421 ggaggatcgg tagcagcgtc tggtccagcc tcttcaacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003445             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:3358:15216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003445
VERSION     KCXD01003445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:3358:15216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..438
     V_segment       78..368
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <360..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61927.1"
                     /translation="CAKGETAAVYYGLDSW"
     D_segment       375..386
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       387..438
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           93 a          116 c          132 g           99 t
ORIGIN      
        1 acatggggag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
       61 taagaggtgt ccggtgtgag gtgcagctgg tcgagtccgg gggcggcttg gcgaagcctg
      121 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tacgccattc
      181 actgggtccg ccaggctcca gggaagggac tggagtgggt ctcagccatt agtagtggtg
      241 gcagcacatt ctacgcagcc tccgtgaagg gccgattcac catctccaga gacaattcaa
      301 agaacacgct ctccctacaa atgaacagcc taacaactga ggacacggcc atgtattact
      361 gtgcgaaagg agaaacagct gcagtttact acggtttgga ttcctggggc caaggggtcg
      421 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003446             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22797:18390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003446
VERSION     KCXD01003446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22797:18390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61928.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          114 a          141 c          129 g           93 t
ORIGIN      
        1 acatggggac acacaaccat cacatccctc ccctacagaa gccccagagc acatcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt gttcatcctg aatatggtaa agtagactac
      301 acacagaagt tccgagacag agtcaccatc accgcggaca tgtcgacaga gacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtttc ctcagcc
//
LOCUS       KCXD01003447             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19722:10386
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003447
VERSION     KCXD01003447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19722:10386"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61929.1"
                     /translation="CVRYEDEAINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          137 c          129 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tgactccatc accagtagct actggaactg gatccgccag ccccccggga agggactgga
      241 atggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcagc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaag ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003448             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11925:16450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003448
VERSION     KCXD01003448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11925:16450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61930.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..432
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          114 a          142 c          141 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atacaccttc accgaaatat ccatgcactg ggtgcgacag
      241 gcccccggaa aaggacttga gtggatggga agtgttgatc ctgtgtatag tgaagaaata
      301 ctcgcagata atttccacga cagagtcacc atgaccgagg acacgtctac aggcacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tatatttctg tgcggcgggc
      421 cttggggggt atctagtgct tactgaatac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01003449             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16787:11143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003449
VERSION     KCXD01003449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16787:11143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61931.1"
                     /translation="CARDVYGCGLDYW"
     D_segment       440..445
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          114 c          152 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcgc cttcagtagg tttggcatgc
      241 actgggtccg ccagactcca ggaaaggggc tggagtgggt ggcagttatg tcgtctgatg
      301 gaagtaggat atactacgca gactctttga aagaccgatt caccatatcc agagacaatt
      361 ccaagaacat gctatatctt caactgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agatgtctat ggctgtgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003450             290 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19580:2452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003450
VERSION     KCXD01003450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 290)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 290)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19580:2452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..288
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..288
     V_segment       8..211
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <207..>257
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61932.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       216..236
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..288
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        289..>290
                     /gene="IGHG"
BASE COUNT           68 a           82 c           82 g           58 t
ORIGIN      
        1 acatgggcac cgaattatcc attcactggg tgcgacaggc ccctggaaaa gggcttgagt
       61 ggatgggagg cgttgatcct gcatatggtg agtttacacc cggagagaag ctccagggca
      121 gagtcaccat gaccgaagac acgtctatag acacagccta catggagctg agcagcctga
      181 attctgacga cacggccgtc tattactgtg ctgccgggta tagcggcagc tggaaccact
      241 ggtacttcga tctctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003451             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12977:11151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003451
VERSION     KCXD01003451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12977:11151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61933.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       439..451
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          108 c          158 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctg ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag caacggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagtgat atcgtttgat
      301 gaaagtaaga aatactatgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacttgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagactctta tggaagtggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003452             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10765:10481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003452
VERSION     KCXD01003452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10765:10481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61934.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          123 c          147 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttcctttg
      241 gcatgcactg ggtccgccag gcaccgggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaac taacaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag
      361 acaactccaa gaacatacta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01003453             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7167:19756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003453
VERSION     KCXD01003453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7167:19756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..466
     V_segment       88..380
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61935.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       386..393
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          125 c          147 g          100 t
ORIGIN      
        1 acatggggcc tgggaacaca gctcatcacc atggacttga cctggaggct cctctttgtg
       61 gtggcagcag ctacaggtgc ccagtcccag gtccagctgg tgcagtccgg ggctgaggtg
      121 aagaagcctg gggcctcagt gaagctctcc tgcaaggctt ctggatacac gttcagcatc
      181 tatgccatca gttgggtgcg acaggcccct ggacaagggc ttgagtggat gggagggatc
      241 atccctcttg ttgatataac aaactacgca cagaggttcc agggcagagt cacgatttcc
      301 gcggacacgt ccacaagcac agcctacatg gagctgagca gcctgagatc tgaggacacg
      361 gccgtgtatt actgtgcgag gggagattgt actgatactg actgctcttc cgcggggggc
      421 gcctttgatt tctggggcca agggctcagg gtcaccgtct cttcagcc
//
LOCUS       KCXD01003454             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12253:8434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003454
VERSION     KCXD01003454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12253:8434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..459
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61936.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           92 a          138 c          130 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc aacaatcaac tctccctgaa ggtgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc tctcctcagc c
//
LOCUS       KCXD01003455             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19543:7607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003455
VERSION     KCXD01003455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19543:7607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61937.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       439..443
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          119 c          151 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca tctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctttgg
      241 catgcactgg gtccgccagg ctccaggaaa ggggctggac tgggtggcag ttatgtcgtc
      301 tgatggaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagatg tctttggcgg ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003456             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18045:16973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003456
VERSION     KCXD01003456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18045:16973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..494
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61938.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       442..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          150 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aactttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagaaacttt
      241 ggcatgcact gggtccgcca ggccccaggg aaggggctgg attgggtggc agttatgtcg
      301 tttgatgaaa atgtgaaatt ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 ctgtattact gtgcgagagg ggaatacagt aattctattg acttctgggg ccagggagtc
      481 ctggtcaccg tctctcagcc
//
LOCUS       KCXD01003457             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7425:12794
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003457
VERSION     KCXD01003457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7425:12794"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61939.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          114 a          112 c          158 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tgtattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01003458             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19124:3818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003458
VERSION     KCXD01003458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19124:3818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..471
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61940.1"
                     /translation="CARYDDDDYGYYYLDYW"
     D_segment       408..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           94 a          135 c          131 g          113 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gttgtctctg
      181 gtggctccat cagcaatagt tactggttct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg ctatatctat ggttctactg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcag catttcaaca gacacgtccg aggaccagtt ctccctgaag ttgagttctg
      361 tgaccgccac ggacaccgcc gtgtattatt gtgcgagata tgacgacgat gattacggtt
      421 actattacct tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003459             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22230:4316
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003459
VERSION     KCXD01003459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22230:4316"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..478
     V_segment       118..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61941.1"
                     /translation="CARGSNVWVPDFDYW"
     D_segment       423..430
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          116 a          131 c          142 g           91 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccagctgg tgcagtctgg ggctgaagtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacag cgtcaccgaa ttatgcatac actgggtgcg acaggcccct
      241 ggaaaaggcc ttgagtggat gggaagtgtt gatcctgtaa atgaggcaat aatagacgct
      301 gagaacttcc agggcagact caccatgacc gaggacacgt ctactgacac agcctacatg
      361 gagctgagga gcctgagatc tgaggacacg gccgtgtatt attgtgccag agggagcaac
      421 gtgtgggtac cggactttga ctactggggc cagggagtcc tggtcaccgt ctcttcagcc
//
LOCUS       KCXD01003460             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:27443:6591
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003460
VERSION     KCXD01003460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:27443:6591"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..279
     V_segment       8..204
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61942.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       218..224
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       228..279
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           73 a           74 c           78 g           56 t
ORIGIN      
        1 acatgggatc catacactgg gtgcgacagg cccctggaaa agggcttgag tggatgggaa
       61 gtgttgatcc tcaatatggt gaaatgatag acgcagagaa attccagggc agagtcacca
      121 tgaccgagga cacgtctaca gacacagcct acatggagct gagcagtctg agatctgagg
      181 acacggccgt gtattactgt gcgacatcat ccagcggcac ctggctatac tggtacttcg
      241 atatctgggg ccctggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01003461             388 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8073:5963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003461
VERSION     KCXD01003461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 388)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 388)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8073:5963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    32..386
                     /note="immunoglobulin heavy chain variable region"
     V_region        32..386
     V_segment       32..311
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>355
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61943.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       325..335
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       337..386
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        387..>388
                     /gene="IGHG"
BASE COUNT           84 a          110 c          116 g           78 t
ORIGIN      
        1 acatggggca gcagctacag gcgcccactc tgaagtccag ctggtgcagt ctggggctga
       61 ggtgaagaag cctggggcct cagtgagggt ctcctgcagg atttccggat acaccttcac
      121 cgaattatcc atacactggg tgcggcaggc ccctggaaaa gggcttgagt ggatgggaag
      181 tgttgatcct ctgtatggtg aaatgaagtt ccagggcaga gtcaccatga ccgaggacac
      241 gtctacagac acagcctact tggaactgag cggcctgact tctgaggaca cggccgtgta
      301 ttactgtgcg actggcccta ccggcacctg gaacgcctgg tacctcgata tctggggccc
      361 tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01003462             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:26227:10836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003462
VERSION     KCXD01003462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:26227:10836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61944.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          139 c          134 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgagttatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003463             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9457:4498
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003463
VERSION     KCXD01003463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9457:4498"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61945.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       411..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           90 a          137 c          129 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc aactcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatcg gcaatagcta ctggatctgg atccgccagc ccccagggaa ggggctggag
      241 tggatagggt ctatctatgg tagtactggg agcacctttt acgacccctc cctcaagggt
      301 cgagtcaccg tttcaacaga cacgtccaag aacctatttt ccctgactct ggactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatata gcgatactga tagttattac
      421 ttctttgact actggggcca gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003464             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21258:19771
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003464
VERSION     KCXD01003464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21258:19771"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61946.1"
                     /translation="CARELCSSSVCAGAFDYW"
     D_segment       425..430
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          138 c          141 g          105 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccccatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccacctggtg cagtccggga ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg taaggcttct ggattcaccc tggacaacta tggtgtcaac tgggtgagac
      241 agacccctgg acaaggactt gagtggatgg gggtgatcat cccccttgtt ggtataatta
      301 attacgcaga gaagttccag ggcacagtca ccattaccgc ggacacgtcc acagacacag
      361 cctacatgga gttcagcagc ctgagatctg aggacacggc catctactat tgcgcgagag
      421 aactttgtag ctctagtgta tgtgccgggg cctttgatta ctggggccag ggagccctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003465             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9428:12684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003465
VERSION     KCXD01003465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9428:12684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61947.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          112 a          141 c          138 g           99 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataga
      301 cgcagaaaag ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcaat tggctttttt ggtacttcga tttttggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003466             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:10399:10662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003466
VERSION     KCXD01003466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:10399:10662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61948.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          115 c          151 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcggccgg
      181 gggggtccct gagactctcc tgtgcagtct ctggattcac cttcaatacc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgaatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtacgag agacgcattt ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003467             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:27470:14219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003467
VERSION     KCXD01003467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:27470:14219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61949.1"
                     /translation="CARDAFGSGLDYW"
     D_segment       448..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          118 c          151 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctctcttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatatg
      241 gcatacactg ggtccgccag gctccaggga aggggctggg gtgggtgaca gttatttcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgcttcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct taaattggag gacacggccg
      421 tgtattactg tgcgagagat gctttcggca gcgggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003468             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15485:11005
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003468
VERSION     KCXD01003468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15485:11005"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..463
     V_segment       115..406
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61950.1"
                     /translation="CARADRGSSIDYW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>469
                     /gene="IGHG"
BASE COUNT          108 a          113 c          143 g          105 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaagac tcaccatgaa gtttgggctg agtgtccagt gtggggtgca
      121 gctggtggag tctggaggag gcttggttca gcctgggggg tccctgagac tctcctgtgt
      181 agcctctgga ttcaccttca gaacctatgg catgcactgg gtccgccagg ccccagggaa
      241 ggggctggag tgggtggcgg ttatatcata tgatgatgac aagaaatatt acgcagactc
      301 tgtgaaggac cgattcacca tctccagaga caattccaag aacattcttt atcttcaaat
      361 gaacaacctg aaattggagg acacggccgt gttttattgt gcgagagcgg atcgcggcag
      421 ttcaattgac tactggggcc agggagtcct ggtcaccgtc tccccagcc
//
LOCUS       KCXD01003469             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18038:17606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003469
VERSION     KCXD01003469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18038:17606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61951.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       401..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           89 a          136 c          133 g          100 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagccgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct gtctctggtg
      181 actctatcag caattactac tggaactgga tccgccaggc cccagggaag agactggagt
      241 ggattggctt tatctatggt agtgctagta gtaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccagga accaggtctc cctgaacctg gactctgtga
      361 ccgccgcgga cacggccgtc tattactgtg cgagcgggag gcggcagctg gattttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003470             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:27988:14979
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003470
VERSION     KCXD01003470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:27988:14979"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61952.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       437..442
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          112 c          158 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cgggggggtc cctgagactc tcctgtggag cctctggatt caccttcagt acttttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa aaaatactac gcagactctg tgaaggcccg attcaccgtc tccagagaca
      361 attccaagaa cgtgttatat cttcaaatgg acaacctgaa attggaagac acggccgtgt
      421 attactgcgc gagagatgtc tgggggaggg gatttgacta ttggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003471             291 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14314:9325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003471
VERSION     KCXD01003471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 291)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14314:9325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..289
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..289
     V_segment       8..201
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <193..>258
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61953.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       206..227
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       239..289
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        290..>291
                     /gene="IGHG"
BASE COUNT           66 a           80 c           81 g           64 t
ORIGIN      
        1 acatggggga gctggatccg ccagccccca gggaagggac tggactggat tggacgtatc
       61 tctggtacta gtggggacac caattacaat ccctccctca agagtcgagt caccatttca
      121 acagacacgt ccaagaacca cttctccctg aagctgaact ctgtgaccgc cgcggacgcg
      181 gccgtgtatt attgtgcaag agcggattac gaggatgatt acggttatca tttaggatac
      241 aactggttcg atgtctgggg cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003472             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13753:17174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003472
VERSION     KCXD01003472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13753:17174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61954.1"
                     /translation="CARWSAANFDYW"
     D_segment       403..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           88 a          137 c          135 g           98 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgggcaa gaacatgaag catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccctcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcaa cagtggttat ggctggagct gggtccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtgtctctat gatagtagtg ggaacacgta ctacaacccc tccctcaaga
      301 gtcgcgtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaac ctgaggtcta
      361 tgaccgccgc ggacacggcc gtctattact gtgcgagatg gtcggcagcc aactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003473             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24397:9912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003473
VERSION     KCXD01003473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24397:9912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61955.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          142 c          142 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctggggcc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggaatt gagcagcctg acatctgagg acacggccgt gtatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaatctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003474             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:15018:16558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003474
VERSION     KCXD01003474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:15018:16558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61956.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          111 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggcaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003475             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:23010:22594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003475
VERSION     KCXD01003475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:23010:22594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61957.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          123 c          149 g          104 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagtgtcac cgaattatcg attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct ggaaaaggtg aagaaattca
      301 cggagaggag ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagttg agcaacctga gatctgagga cacggccgtg tattattgtg cgagtgggtt
      421 tagtgtctgg ttatttaacg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003476             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9422:7846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003476
VERSION     KCXD01003476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9422:7846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61958.1"
                     /translation="CATGRFGSSVWSTLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          143 c          150 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgagatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gacatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccaccctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003477             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16099:18146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003477
VERSION     KCXD01003477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16099:18146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61959.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          120 c          151 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca ctgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cggcctgggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtaatttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttatatcg
      301 tctgatgaaa gtaagaaata ctatgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatact atatcttcaa atgaacaacc tgaagttgga cgacacggcc
      421 gtctattact gtgcgagaga cgcatttggc agcggctgtg actactgggg ccggggcgtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003478             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9726:14415
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003478
VERSION     KCXD01003478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9726:14415"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..486
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61960.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>490
                     /gene="IGHG"
BASE COUNT          121 a          140 c          134 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcggcc
//
LOCUS       KCXD01003479             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14096:4811
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003479
VERSION     KCXD01003479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14096:4811"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..451
     V_segment       100..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61961.1"
                     /translation="CASGSRRQPDKW"
     D_segment       402..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..451
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           85 a          137 c          139 g           92 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga gcatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagcccc cagggaaggg gctggagtgg
      241 attggatata tcggtggaac tagtgggagc acctactaca acccctccct caagagccga
      301 gtcaccattt caacagacac gtccaagaac caggtctccc tgaagttgat cactgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agtggaagtc ggcggcagcc ggataaatgg
      421 ggccagggcc tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003480             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10330:20100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003480
VERSION     KCXD01003480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10330:20100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61962.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          111 c          156 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagt agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgaa tcgcatgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaact ggtggatatg gccatgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003481             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:2798:17690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003481
VERSION     KCXD01003481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:2798:17690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..491
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61963.1"
                     /translation="CARDAGYGDSISLVDINMFPHFDYW"
     D_segment       423..435
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT           98 a          136 c          140 g          119 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tggaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgctg tctctggtgc
      181 ctccatcagt agttactggt ggacttggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggta atagtggtag tgtttactcc aacccttccc tcatcagtcg
      301 agtctccatt tcaaaagacg cgtccaagaa tcagttctcc ctgaagctaa gctctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagagatgcc gggtatgggg attcgatatc
      421 actagtcgat attaatatgt tcccccactt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003482             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4769:10493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003482
VERSION     KCXD01003482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4769:10493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61964.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       432..445
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          117 a          144 c          150 g           96 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccacctggt gcagtctggg gctgaggtga agcagcctgg ggcctcagtg
      181 aaggtctcct gtaaggtttc cggatacacc gtcagcgaat tgtccatgca ctgggtacga
      241 caggcccctg ggaaagggct tgagtggatg ggagttgttg atcctgtcaa tggtgaagaa
      301 atacacgcag agaagttcca gggcagagtc accatgaccg aggacacgtg gacagacaca
      361 gcctacatgg acttgaccag tctcagatct gaggacacgg ccatctatta ctgtgcgaca
      421 gggaggatcg gtagcagcgg ctggtccaac ctcttcaccg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003483             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6292:19101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003483
VERSION     KCXD01003483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6292:19101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61965.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          124 c          160 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tcggggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agcctctggt ttcagattca gttactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat aatacatact atgcagactc cgtgaagggc cgattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcacat ggacagcctg agaggtgagg acacggctgt
      421 ctattactgt gcgagagacc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003484             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:8496:3818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003484
VERSION     KCXD01003484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:8496:3818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61966.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       439..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          110 c          150 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgacctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggagccttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcttc tggattcacc ttcagtagtt atggcatgca
      241 ctgggtccgc ctggctccag ggaaggggct ggagtgggtg gcagttacat cgtctgatga
      301 aagtaagaaa tactacggag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacata ctatatcttc aaatgaacaa cctgaaattg aaggacacgg ccgtgtacta
      421 ctgtgggaga gatgataatg gggtgattat cgactactgg ggccagggag tcctggtcac
      481 cgtgtcctca gcc
//
LOCUS       KCXD01003485             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11448:6274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003485
VERSION     KCXD01003485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11448:6274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61967.1"
                     /translation="CARNRFMGVRVLAYW"
     D_segment       402..406
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           95 a          137 c          131 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtcca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcggttacta ctggaactgg atccgccaac caccagggaa gggcctggag
      241 tggattgggt atatcgctgg tagtagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag agccaattct ccctgaagct gaactctgtg
      361 accgccgcgg acacggccat ctattactgt gcgagaaata gatttatggg tgtaagggtt
      421 cttgcctact ggggccaggg agtcctggtc gccgtctcct cagcc
//
LOCUS       KCXD01003486             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24855:4779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003486
VERSION     KCXD01003486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24855:4779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61968.1"
                     /translation="CVRDVYGTGFDYW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          116 c          150 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ctccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 ctgatgaaaa taacatatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgggcaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtctacggta ccggatttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003487             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11384:15692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003487
VERSION     KCXD01003487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11384:15692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61969.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          138 c          128 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagcttt ccctgagact gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003488             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:3967:8272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003488
VERSION     KCXD01003488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:3967:8272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61970.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          137 c          128 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctatccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccacc ccccagggaa ggggctggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003489             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11269:9226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003489
VERSION     KCXD01003489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11269:9226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..328
     V_segment       8..252
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <244..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61971.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       254..260
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           75 a           82 c          100 g           73 t
ORIGIN      
        1 acatgggcag tgaaggtctc ctgcaaagtt tccggataca ccttcaccga tttatccatg
       61 cactgggtgc gacaggcccc tggaaaaggg cttgagtgga tgggaggtgt tgatactgta
      121 tctgatggag tgatatacgc agagaacttc cagggcagag tcaccatgac cgaggacacg
      181 tctacagaca cagcctacat ggagctgagc agcctgagat ctgaggacac ggccgtttat
      241 tactgtgcga gaggtgtgac agcagacgtc ttcggtttcc tcgggcttga ctactggggc
      301 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003490             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:9638:5503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003490
VERSION     KCXD01003490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:9638:5503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..464
     V_segment       83..380
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <371..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61972.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       386..403
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          106 a          138 c          117 g          105 t
ORIGIN      
        1 acatggggga atcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggccttgt cccaggtcac cttgaaggag tctggtcctg cgctcgtgaa
      121 acccacacag accctcacgt tgacctgcac cttctctggg ttctcaatca gctctactgg
      181 aagaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccat
      241 ttattggaat gatagtaaat actacagcac atcgctgaag agcaggctca ccgtctccaa
      301 ggacacctcc aaaaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc
      361 caaatattac tgtgcacggg attactgtag tgggatttac tgcgatgtaa atgggcacta
      421 ctttgacctc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003491             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19752:10662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003491
VERSION     KCXD01003491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19752:10662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61973.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          113 a          117 c          148 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc aatcactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01003492             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24823:7076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003492
VERSION     KCXD01003492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24823:7076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..491
     V_segment       144..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61974.1"
                     /translation="CTGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          109 a          131 c          152 g          105 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agatggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga atgggtctca gctattaata
      301 ctgatgggga gaacacatac tacgcagact ccgtgaaggg ccgattctcc atctccagag
      361 acaactcaaa gaccacactc tccctgcaaa tgaacagcct gagaccggag gacacggccg
      421 tatattactg tacgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc cacagcc
//
LOCUS       KCXD01003493             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14789:3853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003493
VERSION     KCXD01003493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14789:3853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61975.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          114 c          151 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtacagc tggtggagtc tggaggagac ttggttcacc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca
      241 tacactgggt ccgccagggt ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaactag gacatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgatattt cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagagatgtc aggggaacgg ggtttgacta ctggggccag ggagtcctgg
      481 tccccgtctc ctcagcc
//
LOCUS       KCXD01003494             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14662:6018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003494
VERSION     KCXD01003494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14662:6018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..472
     V_segment       119..412
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61976.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       416..431
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>475
                     /gene="IGHG"
BASE COUNT          101 a          147 c          123 g          104 t
ORIGIN      
        1 acatggggct ccctcaccgc acagctggga tctcagtgct tcatttctgt cctccaccac
       61 gatggggtca actgccatcc tcgccctcct cctggctgtt ctccaaggag tctgtgccga
      121 ggtgcagctg gtgcagtctg gaacagaggt gaaaaggccc ggggagtctc tgaggatctc
      181 ctgtcagacc tctggataca actttcccag cagctggatc acctgggtgc gccagatgcc
      241 cgggaaaggc ctggagtgga tggggaccat ctatcctgct gattctaatg ccaaatacaa
      301 cccgtccttc caaggccacg tcactatctc agtcgacaag tccatcagca ccacctactt
      361 gcagtggagc aacctgaagg cctcggacac cgccacgtat tactgtgcca aaacctacta
      421 tagtggtagt ttggaatact ggggccaggg agtcctggtc accgtctcct caacc
//
LOCUS       KCXD01003495             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7615:12503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003495
VERSION     KCXD01003495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7615:12503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..453
     V_segment       69..360
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61977.1"
                     /translation="CATGVYYQDEYGSFYIGGDFDYW"
     D_segment       369..390
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           93 a          120 c          139 g          103 t
ORIGIN      
        1 acatggggac catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg
       61 cccagtccca ggtccacctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag
      121 tgaagctctc ctgcaaggcc tctggataca ccttcagcgt ctctgccatc agttgggtgc
      181 gacaggcccc tggacaaggg cttgggtgga tgggagggat catccctctt gttggtatga
      241 cagactacga acagaaattc cagggcagag tcacgattac cgcggacacg tccacgaata
      301 cagtcttcct ggacctgagc agcctgagat ctgaggacac ggccgtctat tattgtgcga
      361 caggggtata ttaccaggat gaatacggtt ctttttatat cggcggtgac tttgactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003496             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23103:10282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003496
VERSION     KCXD01003496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23103:10282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61978.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           95 a          147 c          146 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtctcc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003497             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:6517:9905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003497
VERSION     KCXD01003497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:6517:9905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61979.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccaatcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa attctacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003498             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:13323:17857
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003498
VERSION     KCXD01003498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:13323:17857"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..329
     V_segment       7..268
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <260..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61980.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       277..282
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       288..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           77 a           80 c           97 g           77 t
ORIGIN      
        1 acatggggtt cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt
       61 cggaacctat ggcattcact gggtccgcca ggctccaggg aagggcctgg agtgggtgac
      121 ggttatatcg aatgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcag
      181 catctccaga gacaattcca agaacatgct atatcttcaa atgaacaacg tgaaattgga
      241 ggacacggcc gtttattact gtgtgagaga tgcgtttggt agcgggcttg actcctgggg
      301 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003499             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23590:21558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003499
VERSION     KCXD01003499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23590:21558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61981.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          121 c          146 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtgcctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacaacctga gagctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cactacagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003500             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23784:6219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003500
VERSION     KCXD01003500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23784:6219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61982.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          111 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcgccttc agtaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcgt
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagaggg gaatatagta actctattga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003501             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:27695:13785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003501
VERSION     KCXD01003501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:27695:13785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..476
     V_segment       111..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61983.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       410..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>479
                     /gene="IGHG"
BASE COUNT          110 a          139 c          132 g           98 t
ORIGIN      
        1 acatgggaac cacatccctc ccctacagaa gccccagagc gcagcacctc accatggact
       61 ggacctggag gatcctcctc ttagtggcag cagctacagg cgcccactct gaggtccagc
      121 tggtgcaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc tcctgcaagg
      181 tttccggata caccttcagc gatttatcca tacactggat acgacaggcc cctggaaaag
      241 ggcttcagtg gatgggaagt gttgatcctg cttttggtga aatgataaac gcagagaagt
      301 tccagggcag agtcaccatg accgaggaca cgtcttcaga cacagccttc atggaattga
      361 gcagcctgaa atctgacgac acggccgtgt atttctgtgc gagtggccct agcggcacct
      421 ggatcgactg gtccttcgat gtctggggcc ctggcacccc aatcaccgtc tcctcaacc
//
LOCUS       KCXD01003502             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8368:4827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003502
VERSION     KCXD01003502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8368:4827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..328
     V_segment       8..258
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61984.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       262..269
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           71 a           98 c           87 g           74 t
ORIGIN      
        1 acatgggcgg agaccctgtc cctcacctgc gctgtctctg gtgactccat cagcagtagc
       61 tactggaact ggatccgcca gcccccaggg aagggactgg agtggattgg gtacatctct
      121 ggtgcttatg ggagcaccag ctacaacccc tccctcaaga gtcgaatcac catttcaaca
      181 gacacgtcca agaaccagtt ttccctgggg ctgagttctg tgaccgccgc ggacaccgcc
      241 gtgtattact gtgtgagata tgaggatgaa tccattaatt accactttga ctactggggc
      301 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003503             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14223:15272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003503
VERSION     KCXD01003503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14223:15272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..493
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61985.1"
                     /translation="CARADRGSSIDYW"
     D_segment       444..450
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          112 a          115 c          151 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaagac tcaccatgaa gtttgggctg agttgggttt tccttgttgc
      121 aattttaaga ggtgtccagt gtggggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gaacctatgg
      241 catgcactgg gtccgccagg ccccagggaa ggggctggag tgggtggcgg ttatatctta
      301 tgatgatgac aagaaatatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacattcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gttttattgt gcgagagcgg atcgcggcag ttcaattgac tactggggtc agggagtcct
      481 ggtcaccgtc tccccagcc
//
LOCUS       KCXD01003504             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24820:12574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003504
VERSION     KCXD01003504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24820:12574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61986.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          114 a          117 c          146 g          131 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg tggagcagct ggtggaatct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagtt cctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctggagtgg gtttccggta ttaacattgg
      301 cggtgacaca tactacccag actctgtgaa gggtcgattc actatctcca gagacaatgc
      361 caagaactcc ttgtatcttc aaatgaacag cctgagagtt gaggacactg ctgtgtattt
      421 ttgtacaagg gggatagata actaccactt tagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003505             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:2945:8490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003505
VERSION     KCXD01003505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:2945:8490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..467
     V_segment       113..406
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61987.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       410..422
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT          105 a          109 c          142 g          113 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agtgtccagt gtgaggtgca
      121 gttggtggag tctggaggag gcttggttca gcctgggggg tccctgagac tctcctgtgc
      181 agcctctgga ttcaccttca gtaactttgg catgcactgg gtccgccagg ctccagggaa
      241 ggggctggat tgggtggcag ttatgtcgtt tgatgaaaat gtgaaattct acgcagactc
      301 tgtgaaggac cgattcacca tctccagaga cagttccaag aacatgcttt ttcttcaaat
      361 gaacaacctg aaattggagg acacggccct gtattactgt gcgagagggg aatatagtaa
      421 ctctattgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003506             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10389:17223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003506
VERSION     KCXD01003506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10389:17223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61988.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       449..454
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          117 a          112 c          156 g          117 t
ORIGIN      
        1 acatgggggg aggtctggga gaggagccca gccctggaag tccacagtgt tccaatcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tgctatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt
      181 tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
      241 tggcatacac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc
      301 gtatgatgaa actaagaaat tctacgcaga ctctgtgagg gaccgattca ccatctccag
      361 agacaattcc aaaaacatgg tatatcttca aatgaacaac ctgaaattgg aggacacggc
      421 cgtatattac tgtgtgagag atgtcagggg aacggggttt gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003507             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19325:8650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003507
VERSION     KCXD01003507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19325:8650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61989.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           99 a          138 c          134 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccctcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atcagtgcta gtagtggaaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgcccaagaa ccagttctcc ctgatgctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtcttct cagcc
//
LOCUS       KCXD01003508             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15028:13122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003508
VERSION     KCXD01003508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15028:13122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61990.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          112 a          141 c          133 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagttggta cagtctgggg ttgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg agaaggactt gagtggatgg gaggtgttca tcctgaattt ggtaaagtag
      301 actacgcaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01003509             539 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17537:9878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003509
VERSION     KCXD01003509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 539)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 539)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17537:9878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    171..537
                     /note="immunoglobulin heavy chain variable region"
     V_region        171..537
     V_segment       171..462
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <456..>506
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61991.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       476..482
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       489..537
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        538..>539
                     /gene="IGHG"
BASE COUNT          124 a          150 c          152 g          113 t
ORIGIN      
        1 acatgggggc cctggtgtct gccgaggtaa atacagatct gtccttgtcc agagagcatc
       61 acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc accatggact
      121 ggacctggag gatcctcctc ttggtggcag caggtacagg cgcccactct gaggtccagc
      181 tggtgcagtc gggggctgag gtgaagaagc ctggggcctc agtgaaggtc tcctgtaagg
      241 tttccggata caccttcacc gaattatcca tgcactgggt gcgacaggcc cctggaaaag
      301 ggcttgagtg gatgggaagt gttgatcctg tttttggtga aataatgaat tcagagaagt
      361 tccagggcag agtcgccttg accgaggaca cgtctacaga cacagcctac atggagttga
      421 gcagcctgag atctgaggac acggccgtgt attactgtgc gacatcatcc agcggcacct
      481 ggctatattg gtacttcgat gtctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003510             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8900:5522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003510
VERSION     KCXD01003510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8900:5522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61992.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       416..431
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          100 a          144 c          125 g          106 t
ORIGIN      
        1 acatggggtc tccctcaccg cacagctggg atctcagttc ttcatttctg tcctccacca
       61 cgatggggtc aactgccatc ctcgccctcc tcctggctgt tctccaagcg tctgtgccga
      121 ggtgaaactg gtgcagtctg gggcagaggt gagaaggccc ggggagtctc tgaagatctc
      181 ctgtaagact tctggataca gctttaccac caactggatc agttgggtgc gccagacgcc
      241 cggaaaaggc ctggaatgga tggggaccat ctatcctgct gattctgagg ccaaatacaa
      301 cccgtccttc caaggccacg tcactatctc agccgacaag tccatcagta ccacctacct
      361 gcagtggagc agcctgaagg cctcggacac cgccacgtat ttctgtgcga aaacctacta
      421 tagtggtagt ttggaaatct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003511             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13811:9088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003511
VERSION     KCXD01003511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13811:9088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61993.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          116 a          120 c          145 g          127 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgaac tgggttttcc ttgtttctat
      121 attaaaaggt gtccagtgtg tggagcatct ggtggagtct gggggaggct tggtacagcc
      181 tggggcgtcc ctgaagctct cctgtgcagc ctctgagttc accttcagtg actatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctagaatgg gtatcaggta ttaacattgg
      301 cggtgaccca tactacccag actctgtgaa gggtcgattc accatctcca gagacaacgc
      361 caagaactcc ttgtatcttc aaatgaacaa cctgagacct gaggacactg ctgtgtatta
      421 ttgtgtgagg gggatggata actaccactt cagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003512             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21049:15275
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003512
VERSION     KCXD01003512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21049:15275"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61994.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       441..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          132 c          151 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgagc ctctcctgtg tagcctctgg attcaccttc agtacctatt
      241 ccatacactg ggtccgccag actccaggga aggggctgga gtgggtctcc gctattagta
      301 ctgctggtag cacatactac acagactccg tgaagggccg attcaccatc tccagagaca
      361 actcacagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccctgt
      421 attactgtgc gaaaggggag acagcttcag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003513             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21320:13656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003513
VERSION     KCXD01003513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21320:13656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61995.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          110 c          153 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacaca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaagtt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003514             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4895:20799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003514
VERSION     KCXD01003514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4895:20799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61996.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          138 c          132 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgag gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcaatagcta ctggaactgg atccgccagc cccctgggaa ggggctggag
      241 tggattgggt ctatctacgg tggtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt gtattattgt gcgagatatg aggatgaata cagtgactac
      421 tactttgact actggggcca gggaatcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003515             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24174:8587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003515
VERSION     KCXD01003515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24174:8587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61997.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       404..412
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           91 a          137 c          138 g          107 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct ctcctgcact gtctctggtg
      181 gctccttcag tggttactac tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattgggtt tatcggtggt ggtagtggga gcaccgaata caacccctcc ctcaaaagtc
      301 gagtcaccat ttcaagagac acgtccaaga atcaattctc cctgaagctg acctctatgg
      361 ccgccgcgga cacggccgtt tatttctgtg ccagagatgc gggagtggga gccacaatcc
      421 tttactacta tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003516             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15984:10450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003516
VERSION     KCXD01003516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15984:10450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..486
     V_segment       117..410
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61998.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       425..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          112 a          140 c          138 g           98 t
ORIGIN      
        1 acatggggac ccaacaacaa cacccctcca cagaagcccc tggatcacag ctccttgcca
       61 tggactggac ctggaggatc ctcttcttgg tggcagcagc aacaggtgcc cactcccagg
      121 tgcagctggt gcagtcgggg gctgaggtga agcagccggg gacatcagtg gaggtctcct
      181 gcaaggcttc tggctacacc ttcactagct atggtatgaa ctgggtgcga caggcccagg
      241 gacaacggct tgagtggatg ggatggctca acaccgacac tgggaaccca acgtatgccc
      301 agggcttcaa agaacgattt acattctcca tggacacctc tatgaccacg gcatatctgc
      361 atatcagcag cctaaagact gaggacacgg ccgtatactt ctgtgcaaga agtttgggct
      421 ggcatgatta taatgacgtc gcccttgact tctggggcca gggagtcctg gtcgccgtct
      481 cctcagcc
//
LOCUS       KCXD01003517             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12978:11123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003517
VERSION     KCXD01003517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12978:11123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX61999.1"
                     /translation="CARDVYDSGLDYW"
     D_segment       444..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          121 c          147 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agttcctttg
      241 gcatgcactg ggtccgccag gcaccgggga aggggctgga gtgggtggca gttttatcgt
      301 ctgatggaac taagaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag
      361 acaactccaa gaacatacta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtgtatgact cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01003518             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20149:17627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003518
VERSION     KCXD01003518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20149:17627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62000.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          143 c          147 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatgggc tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggagcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgacttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagt tgttgatcct gtaaatggtg aaatgataca
      301 cgcagagatg ttccaggcca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctga gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agcgtctggt ccagcctctt caacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003519             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7059:12924
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003519
VERSION     KCXD01003519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7059:12924"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..378
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62001.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       391..397
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT          106 a           98 c          131 g          106 t
ORIGIN      
        1 acatgggcag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctgttttaa gaggtgtcca gtgtgaggtc cagctggtgg agtctggagg agacttggtt
      121 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      181 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      241 tctgatggaa gtaagacata ctacgcaaaa tctgtgaagg accgattcac catattaaga
      301 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      361 ctctattact gtgcgagaga cgatatggga agtggctttg actactgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003520             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:24589:16047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003520
VERSION     KCXD01003520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:24589:16047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62002.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       414..424
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          108 a          145 c          132 g           92 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaagtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc
      181 tcctgcagga tttccggata caccttcacc gaattatcca tacactgggt gcggcaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc tgtatggtga aatgaagttc
      301 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctactt ggaactgagc
      361 ggcctgactt ctgaggacac ggccgtgtat tactgtgcga ctggccctac cggcacctgg
      421 aacgcctggt acctcgatat ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01003521             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11254:12205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003521
VERSION     KCXD01003521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11254:12205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..479
     V_segment       104..400
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62003.1"
                     /translation="CARVSGRWELFEPGSEDLW"
     D_segment       415..422
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           91 a          136 c          145 g          109 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtggtga agccttcgga gaccctgtcc ctctcctgcg ctgtctccgg
      181 tggctccatc agcggaggtt atggctggag ctggatccgc caggccccag ggaagggtct
      241 ggagtggatt ggttatatct atggtagtag tggaagcacc ttctacaacc cctccctcaa
      301 gagtcgagtc accttttcaa gagacacgtc caagaaccag ttctccctga aactgacctc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gtttcgggca ggtgggaact
      421 atttgagcct gggtcagagg acctctgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01003522             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21010:18740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003522
VERSION     KCXD01003522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21010:18740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62004.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          115 a          111 c          157 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 gtattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01003523             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19312:13950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003523
VERSION     KCXD01003523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19312:13950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62005.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          115 a          143 c          129 g           89 t
ORIGIN      
        1 acatggggca cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttctggatac accttaaccg accactacct gcactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggtg ttcatcctga atatgggaaa gtagactaca
      301 cacagaagtt ccaagacaga gtcaccatca ccgcggacat gtcgacagag acagtctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccactta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgactac tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003524             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5133:8132
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003524
VERSION     KCXD01003524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5133:8132"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62006.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       406..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          141 c          131 g          108 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtgtc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccagtagctt ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ctatctatgg tgctactggg agcaccacct acaaccccgc cctcaagagt
      301 cgagtcacca tttcaacaga gacgtccaag aaccagtttt ccctgagact gagctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgacgatga ttacggttcc
      421 tattaccttg actactgggg ccagggagtc ctggtccccg tctcgtcagc c
//
LOCUS       KCXD01003525             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:24077:4098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003525
VERSION     KCXD01003525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:24077:4098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    151..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        151..523
     V_segment       151..443
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <442..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62007.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       458..472
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          115 a          130 c          149 g          131 t
ORIGIN      
        1 acatggggcc tgcagctctg ggagaggaga cccagccttg ggatttccag ctgtctccac
       61 ttggtgatca gcactgaaca caggagactc gccatggagt ttgtactgag ctgggttttc
      121 cttgttgcta tattaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc
      181 ttggtccagc ctggcgggtc cctgagactc tcctgtgcag cctctggatt cacctccagt
      241 gactatgccc tgagctgggt ccgccaggct tctgggaaag gactggagtg gattggctat
      301 attagaagcc aatataacaa tttcgcgaca gaatacgccc catcggtgaa aggcagattc
      361 gccatctcca gagatgattc aaagaacacg ctatttctgc aaatgagtag cctgaaaacc
      421 gaggacacgg ccgtgtatta ctgcaccacc cattttggtg gtaattatta cttggactac
      481 tttgtctact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003526             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7619:17687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003526
VERSION     KCXD01003526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7619:17687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..508
     V_segment       127..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62008.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       429..452
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          116 a          142 c          146 g          106 t
ORIGIN      
        1 acatggggag catcacataa caaccacgtc cctcctctaa agaagcccct gggaacacag
       61 ctcatcacca tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc
      121 cagtcccagg tccagttggt gcagtccggg gctgaggtga agaggcctgg ggcctcagtg
      181 aagctctcct gcaaggctcc tggatacatc ttcagcatat ctgccatcag ttgggtgcga
      241 caggcccctg gacaagggct tgagtggatg ggagggatca tccctcttgt tggtgtaaca
      301 acctacgcac agaagttcca ggacagagtc acgattaccg cggacacgtc cacaagcaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgagt
      421 ggcggcttcg aggatgataa cggtcactat tatacgacac taacatttca cgattggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003527             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13927:5589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003527
VERSION     KCXD01003527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13927:5589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62009.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       406..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          144 c          126 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acgtgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaac gattaccact ggagctggat ccgccagccc cctgggaagg gactggagtg
      241 gattggacat atctctcata gtcgtggaag caccgactac aacccctccc tcaagagtcg
      301 cgtcaccatt tcaacagaca tgtccaagaa ccagttctcc ctgaagctga gctctgtgac
      361 ccccgcggac acggccgtct attactgtgc gagagatcag gattcttacg tttactatcg
      421 cttctttgac ttctggggcc agggagtcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01003528             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:7083:9385
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003528
VERSION     KCXD01003528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:7083:9385"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..493
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62010.1"
                     /translation="CARADRGSSIDYW"
     D_segment       444..450
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          113 a          116 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaagac tcaccatgaa gtttgggctg agttgggttt tccttgttgc
      121 aattttaaga ggtgtccagt gtggggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gaacctatgg
      241 catgcactgg gtccgccagg ccccagggaa ggggctggag tgggtggcgg ttatatcata
      301 tgatgatgac aagaaatatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacattcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gttttattgt gcgagagcgg atcgcggcag ttcaattgac tactggggcc agggagtcct
      481 ggtcaccgtc tccccagcc
//
LOCUS       KCXD01003529             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10267:5634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003529
VERSION     KCXD01003529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10267:5634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62011.1"
                     /translation="CARDVYGTGLDYW"
     D_segment       410..415
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          104 a          101 c          144 g          118 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgctt ttttaagagg tgtccagtgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc cctgagactc tcctgtgtag
      181 cctctggatt cagtttcagt ggctttggca tgcactgggt ccgccaggct ccagggaagg
      241 ggctggagtg ggtggcagtt atctcgtatg atgaaactaa gaaatattac gcagactttg
      301 tgaaggaccg attcaccgtc tccagagaca atgccaagaa catgctatat attcaaatga
      361 acaacctgaa attggaagac acggccgtgt attactgtgc gagagatgtc tatggcacgg
      421 gacttgacta ctggggcctg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003530             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18899:13221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003530
VERSION     KCXD01003530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18899:13221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62012.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           91 a          133 c          137 g           98 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgag gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggg
      181 ggctccatca gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggatgg ggtgtatcta tgatagtagt ggaaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgaggtct
      361 atgaccgccg cggacacggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003531             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8681:2378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003531
VERSION     KCXD01003531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8681:2378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62013.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          144 c          132 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgac cctgtatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatctga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01003532             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:13520:6625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003532
VERSION     KCXD01003532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:13520:6625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62014.1"
                     /translation="CVRYEDEYSDYYFDHW"
     D_segment       407..422
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          134 c          131 g          108 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtggctccat caccaatagt tattggaact ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtctatctat ggtggtactg ggagcaccgg ctacaatccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgaag ctgacctctg
      361 tgaccgccgc ggacaccgcc gtatattatt gtgtgagata tgaggatgaa tacagtgact
      421 actactttga ccactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003533             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:26464:11580
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003533
VERSION     KCXD01003533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:26464:11580"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62015.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           95 a          131 c          127 g          106 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga gtcgggccca
      121 ggactggtga agtcttcgga gaccctgtcc ctcacctgcg gtgtctctgg tgactccatc
      181 agcaatagct actggaactg gatccgccag cccccaggga agggactgga gtggattggg
      241 tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt gaccgccgcg
      361 gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta ccactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003534             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2593:13653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003534
VERSION     KCXD01003534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2593:13653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62016.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          102 a          125 c          155 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttac tacttcatga
      241 gttgggtccg ccaggctcca gggaaggtgc tggagtggat ctcaggtatt accagtggtg
      301 gggctaacac atactctgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaccac actgtatctt cacatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgtaag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003535             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19082:12418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003535
VERSION     KCXD01003535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19082:12418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62017.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       433..445
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          110 c          144 g          120 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccaatcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcaattggtg gagtctggag gaggcttggt tcagcctggg
      181 gggaccctga ggctctcctg tgcagcctct ggattcacct tcagtaatta tggcttgcac
      241 tgggtccgcc aggctccagt gaaggggctg gagtgggttg cagttatatc gtatgatgaa
      301 aatgtgaaat tctacgcaga ctctgtaaag gaccgattca ccatctccag agacaattcc
      361 aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattac
      421 tgtgcgagag gggaatacag taactctatt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003536             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23695:18831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003536
VERSION     KCXD01003536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23695:18831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62018.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          113 a          143 c          129 g           93 t
ORIGIN      
        1 acatggggtt cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccaa gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtagacta
      301 cacacagaag ttccgagaca gagtcaccat caccgcggac atgtcgacag agacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003537             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20583:13107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003537
VERSION     KCXD01003537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20583:13107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62019.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       417..428
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          138 c          138 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga agaaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgaatatggt gaaatgatgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 gcagcctgag atctgaggac acggccgtct attactgtgc gattggccct agtggcagct
      421 ggaacgactg gtccttcgac atttggggac ctggcacccc aatcaccgtc tcctcagcc
//
LOCUS       KCXD01003538             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17392:14661
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003538
VERSION     KCXD01003538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17392:14661"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62020.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          116 a          143 c          130 g           90 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggg aaagtagact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccac ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003539             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:4496:15579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003539
VERSION     KCXD01003539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:4496:15579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62021.1"
                     /translation="CAREYCTTTDCAGFFDFW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          131 c          142 g          107 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccttc gacaactatg gaatcaactg ggtgcgtcag
      241 gcccctggac aagggcttga gtggatggga gtgaccatcc cccttgttgg tattgtaaat
      301 tatgcagaga agttccaggg cagagtcacg attaacgcgg acacgtccac aaacacagcc
      361 ttcatggagg tgaggagcct gagatctgag gacacggcca tttatttctg tgcgagagaa
      421 tactgtacaa ctacagattg cgccggcttc tttgacttct ggggccaggg agccatggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003540             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20751:12780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003540
VERSION     KCXD01003540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20751:12780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62022.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       412..419
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          102 a          136 c          151 g          105 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctataga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgagga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacacgttc agcatctatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tgtaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacggcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgagggga gattgtactg
      421 atactgactg ctcttccgcg gggggcgcct ttgatttctg gggccaagga ctcagggtca
      481 ccgtctcttc agcc
//
LOCUS       KCXD01003541             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23116:8360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003541
VERSION     KCXD01003541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23116:8360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62023.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           83 a          139 c          138 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga
      241 gtggattggc tttttcggtg gtagtggtgg gagcacctac tacaagtcct ccctccagag
      301 tcgagtcacc atttcaaccg acacgtccaa gaaccagttc tccctgatac tgacctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat
      421 tgactactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003542             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15420:4205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003542
VERSION     KCXD01003542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15420:4205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62024.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          115 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgagaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctctagag
      361 acaattccaa gaacatgctt tatcttgaaa tgaacaacct gacattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01003543             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4503:6412
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003543
VERSION     KCXD01003543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4503:6412"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62025.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       420..428
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          116 a          141 c          132 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggcc gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg acacagctac accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctatatatgg tgaaatacta
      301 cacacagaca agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gagatctgaa gacacggccg tttatttctg tgtggcggct
      421 gatagtggtt acccttttta ctacttcgat atctggggcc ctggcacccc aatcagcatc
      481 tcctcagcc
//
LOCUS       KCXD01003544             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13855:16864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003544
VERSION     KCXD01003544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13855:16864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..467
     V_segment       98..394
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62026.1"
                     /translation="CVRVVETATIYPSFDYW"
     D_segment       398..412
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          137 c          134 g          106 t
ORIGIN      
        1 acatggggct ctgagagtca cggacctcct gtgcaagaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcagctgc aggagtcggg
      121 cccagcagtg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct ctggtggctc
      181 caccagcatt aataactggt ggagttggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggggt gtctatagta ttggtggggt caccgaatac aacccctccc tcaagagtcg
      301 agtcaccatc tcaaaagaca cgtccaagag ccagttctcc ctgaatctga gctctgtgac
      361 cgccgcggat accgccatat attactgtgt gagagtcgtg gagacagcta caatttaccc
      421 ctcctttgac tactggggcc ggggagtcct ggtcatcgtc tcctcagcc
//
LOCUS       KCXD01003545             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22121:19708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003545
VERSION     KCXD01003545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22121:19708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    82..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        82..460
     V_segment       82..373
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <367..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62027.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       396..402
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..460
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT          107 a          123 c          138 g           94 t
ORIGIN      
        1 acatggggag cacagcacct caccatggac tggacctgga ggatcctcct cttggtggca
       61 gcagctacag gcgcccactc tgaggtccaa ctggtgcagt ctggggctga aatgaagaag
      121 cctgggacct cagttagggt ctcctgcaag gtttccggaa acaccttcac cgaattatcc
      181 atgcactggg tgcgacaggc ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct
      241 gcacaaggtg aaataataca cgcagagaaa ttccagggca gagtcaccat gaccgaggac
      301 acgtctacag acacagcctt catggagttg agcagcctga gatctgagga cacggccgta
      361 tatttctgtg cgaaaggggg gttcggaacc agcgtctggt ccaacctctt ctacggtttg
      421 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003546             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18282:2690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003546
VERSION     KCXD01003546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18282:2690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..449
     V_segment       95..391
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62028.1"
                     /translation="CARWSAANFDSW"
     D_segment       396..402
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..449
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           86 a          133 c          136 g           96 t
ORIGIN      
        1 acatgggggg agagtcacgg acctcctggg caagaacatg aagcatctgt ggttcttcct
       61 cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg agtcgggccc
      121 aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtggctccat
      181 caacagtggt tatggctgga gctgggtccg ccagccccca gggaaggggc tggagtggat
      241 tgggtgtctc tatgatagta gtgggaacac gtactacaac ccctccttca agagtcgcgt
      301 caccatttca aaagacacgt ccaagaacca gttctccctg agcctgaggt ctatgaccgc
      361 cgcggacacg gccgtgtatt actgtgcgag atggtcggca gccaactttg actcctgggg
      421 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003547             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:9633:2384
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003547
VERSION     KCXD01003547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:9633:2384"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62029.1"
                     /translation="CARWEAANFDYW"
     D_segment       398..403
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          130 c          138 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggccat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 gtccatcagc ggtggttatg gctggagttg gatccgccag gccccaggga agggactgga
      241 gtggattggg actatgtatg gtcatagtgg cagcacccac tacaatccct ccctcaagag
      301 tcgagtcacc atttcaaaag acatgtccaa gaaccagttt tccctgacgt tgagctctct
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gaggcagcga actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003548             420 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12016:19356
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003548
VERSION     KCXD01003548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 420)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 420)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12016:19356"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    52..418
                     /note="immunoglobulin heavy chain variable region"
     V_region        52..418
     V_segment       52..343
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <337..>387
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62030.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       357..363
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       370..418
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        419..>420
                     /gene="IGHG"
BASE COUNT           99 a          109 c          125 g           87 t
ORIGIN      
        1 acatggggga ggatcctcct cttggtggca gcagcgacag gcgcccactc tgaggtccag
       61 ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag
      121 gtttccggat acatcttaac cgaattatcc atgcactggg tgcgacaggc ccctggaaaa
      181 gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga cgcagagaaa
      241 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      301 agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc cagcggcacc
      361 tggctatatt ggtacttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003549             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:2677:15335
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003549
VERSION     KCXD01003549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:2677:15335"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62031.1"
                     /translation="CSTGHSGRWINWNFEIW"
     D_segment       422..431
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          126 a          138 c          131 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggttgtgca gtctggggct gaagtgaaga agcctgggtc ctcagtgaag
      181 gtctcctgca agatttccgg atacaccttc accgatttat ccatacactg ggtgcgacag
      241 gcccctggaa aaggacttga gtggatggga agtgttgatc ctgcttatgg tgaaatgata
      301 aacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggaat tgggcagcct gaaatctgag gacacggccg tgtattactg ttcaacaggc
      421 catagcggca ggtggattaa ctggaacttc gaaatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003550             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13676:11366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003550
VERSION     KCXD01003550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13676:11366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62032.1"
                     /translation="CARDSDSREFSFDYW"
     D_segment       451..455
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          122 c          145 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggttca cctgctggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggac tgggtggcag ttatatcgta
      301 tgatggaagt aagaaatact acgcagactc tgtgaatgac cgattcacca tctccagaga
      361 caattccaac aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatt ccgactcccg agaattcagt tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003551             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:6154:16757
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003551
VERSION     KCXD01003551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:6154:16757"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..439
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <431..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62033.1"
                     /translation="CTRVKYYYDSGYYVGPFDYW"
     D_segment       446..469
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       479..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          111 a          128 c          151 g          133 t
ORIGIN      
        1 acatggggag ctcggggaga ggagccacag ccccgggatt cccagctgtc tccacttggt
       61 catgaacact gaactcagaa gacgcaccat ggagtttgtg ctgagtttgg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 aaagcctggg gggtccctga gactctcttg tgtagcctct gggttctcct tcagtaccta
      241 tcctttacac tgggtccgcc aggctcccgg gaagggtctg gagtgggtct cagttattag
      301 tgaaactggt ggaaccacat actacgcaga ctctgtgaag ggccgcttca ccatctccag
      361 agacaacgcc aagaactcac tgtttctgca aatgaacagc ctgagagccg aggacacggc
      421 cgtctattat tgtactagag tcaaatatta ctatgatagt ggttattacg tcgggccatt
      481 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003552             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19899:15265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003552
VERSION     KCXD01003552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19899:15265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62034.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          138 c          136 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagtcc ccaggaaagg gactggagtg
      241 gattggacgt atttctggga gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccttt tcaacagaca cgtccaagaa cgagatctcc ctgaaagtga cctctgtgac
      361 cgccgcggac acggccgtat attattgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003553             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20353:6813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003553
VERSION     KCXD01003553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20353:6813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..442
     V_segment       85..381
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62035.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       392..396
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           86 a          135 c          126 g           97 t
ORIGIN      
        1 acatgggggg acatcctgtg caagaacatg aagcacctgt ggttcttcct cctcctggtg
       61 gcagctccca gatgggtcct gtcccaggtg cagctgcagg agtcgggccc aggactggtg
      121 aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtggcgccat cagcagtggt
      181 ttctactgga cctggatccg ccaaccccca gggaaggggc tggagtggat tgggtgtatc
      241 ggtggtaata gtgggaccac ctactacaac ccctccctca agagtcgagc cgccatttca
      301 aaagacacgt ccaacaatca attctccctg aggttgactt ctctgaccgc cgcggacacg
      361 gccgtgtatt actgtgcgag agatgaagac ccctccattt ttgactactg gggccaggga
      421 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003554             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19325:16482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003554
VERSION     KCXD01003554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19325:16482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..286
     V_segment       8..210
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <202..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62036.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       215..235
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..286
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           62 a           80 c           85 g           61 t
ORIGIN      
        1 acatggggtc actactgcag ctggatccgc cagtccccag ggaagggact ggagtggatt
       61 ggacggatct ctggtagtgg tgggagcacc gactacaacc cctccctcaa gagtcgagtc
      121 accctctcaa cagacacgtc caagaaggag atctccctga agctgagctc tgtgaccgcc
      181 gcggacacgg ccgtgtatta ttgtgcgaga gaagactatg gtggtaatta ttactttaac
      241 cggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003555             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15095:7684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003555
VERSION     KCXD01003555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15095:7684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..395
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62037.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       401..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           94 a          141 c          130 g          107 t
ORIGIN      
        1 acatgggggt ctgagagtca gggacctcct gtgcaagaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcaggtc ccagatgggt cctgtcccag ccgcagctgc agctgcagga
      121 gtcgggccca ggactggtga aaccttcgga gaccctgtcc ctcgcctgcg ttgtctctgg
      181 tggctccatc agcgattact cctggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg aatattgatg ttcatctagc gggccccaac tacaacccct ccctcaagag
      301 tcgagtcgcc atttcaaaag acacgtccaa gaatcagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tatatttctg tgcgaaacaa tatagtggta gttattacta
      421 ctcccacttt gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003556             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8029:14903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003556
VERSION     KCXD01003556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8029:14903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62038.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          115 c          153 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg actgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata cttcgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagaga tgtcagggga acggggtttg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003557             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18839:12955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003557
VERSION     KCXD01003557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18839:12955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62039.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          108 c          152 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaaa taagaaatac tactcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccag gaacatcgta tatcttcaaa tgaataacat gaatttggag gacacggccg
      421 tttatttctg tgtgagagat gtcaggggaa cgggatttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003558             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:26071:12357
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003558
VERSION     KCXD01003558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:26071:12357"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62040.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       267..272
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           78 a           73 c           93 g           76 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
       61 gcatacactg ggtccgccag ggtccaggga aggggctgga gtgggtggca gttatatcgt
      121 atgatgaaac taggacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaatttcaa gaacatgata tttcttcaaa tgaacaacct gaaattggag gacacggccg
      241 tgtattattg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003559             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19434:6391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003559
VERSION     KCXD01003559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19434:6391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..488
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62041.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>492
                     /gene="IGHG"
BASE COUNT          120 a          143 c          133 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga atggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctccg cc
//
LOCUS       KCXD01003560             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:3837:7646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003560
VERSION     KCXD01003560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:3837:7646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62042.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          103 a          142 c          128 g          106 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggcaaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctcagccga caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003561             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9307:12125
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003561
VERSION     KCXD01003561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9307:12125"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62043.1"
                     /translation="CARRPWDADAFDFW"
     D_segment       436..440
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>497
                     /gene="IGHG"
BASE COUNT          113 a          114 c          151 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccagcctcca gggaaggggc tgcagtgggt ggcagttata tcgtacgatg
      301 aagataagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaatat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag gaggccctgg gatgcagatg cttttgattt ctggggccaa gggctcaggg
      481 tcaccgtctc tttagcc
//
LOCUS       KCXD01003562             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12892:4924
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003562
VERSION     KCXD01003562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12892:4924"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62044.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           94 a          149 c          132 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggctactact ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actattcttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003563             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:28582:15530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003563
VERSION     KCXD01003563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:28582:15530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..493
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62045.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       432..440
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          143 c          144 g           97 t
ORIGIN      
        1 acatggggaa accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcggcta caggtgccca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggcttctg gatacacctt cagcatccat ggcatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agggatcatc cctcttgttg atttaacaca ctacgcacag
      301 aagttccagg gcagagtcac gattaccgcg gacacgccca caagcacagc ctacatggag
      361 ctgagcagcc tgagatctga ggacacggcc ttttattact gtgcgagagg gacaacccac
      421 ctcgagatgg caactggaat cggagactac tttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003564             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12853:13348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003564
VERSION     KCXD01003564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12853:13348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62046.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          132 c          137 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgatg tctctggggg
      181 ctccatcagc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtatctacg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaaga tgaggtctat
      361 gaccgccgcg gacgcggccg tgtattattg tgcgcgatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003565             371 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:7704:11248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003565
VERSION     KCXD01003565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 371)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 371)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:7704:11248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..369
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..369
     V_segment       8..299
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>338
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62047.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       309..315
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       325..369
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        370..>371
                     /gene="IGHG"
BASE COUNT           80 a           90 c          118 g           83 t
ORIGIN      
        1 acatgggggt gaagctggtg gagtctgggg gcggcttggc aaagcctggg gggtccctga
       61 gactctcctg cgcagcctct ggattcaggt tcaattatta ctacatgagc tgggtccgcc
      121 aggctccagg gaaggggctg gagtggatct caggtattag tagtggtggg gaaagcacat
      181 actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc aagaacacac
      241 tatatcttca aatggacagc ctgagaactg aggacacggc tgtctatttc tgtgtgagag
      301 atcgacgtgt acagtcgtta tcctggttcg atgtctgggg cccgggagcc ctggtcaccg
      361 tctcctcagc c
//
LOCUS       KCXD01003566             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9202:18215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003566
VERSION     KCXD01003566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9202:18215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62048.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       438..444
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          126 c          155 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctggattt tccttgttgc
      121 tcttttgaaa ggtgtccggt gtgaggtgca actggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca cttactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtgggcat agcacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agaattgagg acacggctgt
      421 ctattactgt gcgagagtag tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01003567             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:25661:15285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003567
VERSION     KCXD01003567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:25661:15285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..513
     V_segment       141..433
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62049.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       444..453
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          122 a          115 c          152 g          126 t
ORIGIN      
        1 acatggggtg ggagaggaga cccagccttg ggatttccag ctgtctccac ttggtgatca
       61 gcactgaaca caggagactc gccatggagt ttgtactgag ctgggttttc cttgttgcta
      121 tattaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggcgggtc cctgagactc tcctgtgcag cctctggatt caccttcaat gagtatgcca
      241 tgagctgggt ccgccaggct tctgggaaag gactggagtg gattggctat attagaagca
      301 aatataacga ttacgcgaca gaatatgccg catcggtgaa aggcagattc accatctcca
      361 gagatgattc aaagaacaca ctatatctgc agatgagcag cctgaaaacc gaggagacgg
      421 ccgtgtatta ctgcacccgt ctctatagtg ggaactatag aattatgatg tttgactact
      481 ggggccaggg agtcctggtc agtgtctcct cagcc
//
LOCUS       KCXD01003568             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23153:11704
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003568
VERSION     KCXD01003568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23153:11704"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62050.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          109 c          155 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag tttcagtaat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttatg tcgtctgatg
      301 gaactaagaa attctacgca gactctgtga aggtccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca gcctgaaatc ggaggacacg gccgtgtatt
      421 attgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtcacctc agcc
//
LOCUS       KCXD01003569             411 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17347:4150
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003569
VERSION     KCXD01003569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 411)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 411)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17347:4150"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    55..409
                     /note="immunoglobulin heavy chain variable region"
     V_region        55..409
     V_segment       55..347
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <340..>378
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62051.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       348..354
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       370..409
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        410..>411
                     /gene="IGHG"
BASE COUNT           91 a           91 c          124 g          105 t
ORIGIN      
        1 acatgggggc tgagctgggt tttccttatt gctattttaa gaggtgtcca gtgtgaggtg
       61 cagctggtgg agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt
      121 acagcctctg gattcacctt cagtagctat ggcttacact gggtccgcca ggctccaggg
      181 aaggggctgg agtgggtgac agttatatcg tctgatgaaa gtaggaaata ctacgcagac
      241 tctctgaagg accgattcac catttccaga gacaattcca agaacacgct atatcttcaa
      301 atgaacaacc tgaaattgga ggacacggcc gtgtattatt gtgcgaggga tgataatggg
      361 gtgcttatcg acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003570             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16037:3177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003570
VERSION     KCXD01003570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16037:3177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62052.1"
                     /translation="CASGSRRQPDKW"
     D_segment       406..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..455
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          137 c          141 g           93 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagagcatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tatatcggtg gaactagtgg gagcacctac tacaacccct ccctcaagag
      301 ccgagtcacc atttcaacag acacgtccaa gaaccaggtc tccctgaagt tgatcactgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagtgga agtcggcggc agccggataa
      421 atggggccag ggcctcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003571             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11526:14610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003571
VERSION     KCXD01003571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11526:14610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62053.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       405..418
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          133 c          141 g          106 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacttgcg ttgtctctgg
      181 ccactccatc agcagtggct accactgggg ctggatccgt cagcccccag ggaagggact
      241 ggactatatt ggctatatca gtggtagtag tgggagcacc tactacaagc cctccctcat
      301 gagtcgagtc atcatttcaa gagacacgtc ccggaatgag ttctccctga ggctgaggtc
      361 tgtgactgtc gcggacacgg ccgtgtatta ttgtgcgaga cgagatagct ggaacaacgg
      421 ggggagcctt gactactggg gccagggatt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003572             528 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11843:13752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003572
VERSION     KCXD01003572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11843:13752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..526
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..526
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>495
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62054.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       452..471
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       484..526
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        527..>528
                     /gene="IGHG"
BASE COUNT          114 a          132 c          155 g          127 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg caactggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttac
      241 gacatgacct gggtccgcca ggctccggga aaggggctgg aatgggtctc atatattagt
      301 tacactggta aaaccatata ctactctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaactctct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattatt gttctagagc ggcttacgaa catgatgacg gttactatta cgtcggcagg
      481 ttttttgact gctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003573             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24325:4487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003573
VERSION     KCXD01003573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24325:4487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62055.1"
                     /translation="CARKLPGLQLTGLDSW"
     D_segment       412..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          139 c          132 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tttctggtga
      181 ctccatcacc agtgcctact actggagttg gatccgccaa cccccaggaa aggggcttga
      241 gtggattggg tgtatcggtg gtagtagtgg taacacctac tacaactcct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tctattactg tgcgagaaag cttccggggc tgcaactaac
      421 cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcgtcagcc
//
LOCUS       KCXD01003574             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:26934:13414
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003574
VERSION     KCXD01003574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:26934:13414"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62056.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          109 a          125 c          153 g          128 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgacc aggggctgga gtggatctca gctattgata
      301 gtgctggtac tactaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003575             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22165:9598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003575
VERSION     KCXD01003575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22165:9598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62057.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           88 a          142 c          133 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgcagctga attatgtaac
      361 cgccgcggac acggccgtgt attactgtgc cagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccggggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003576             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14955:12900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003576
VERSION     KCXD01003576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14955:12900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..472
     V_segment       92..383
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62058.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       392..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>478
                     /gene="IGHG"
BASE COUNT          102 a          127 c          144 g          105 t
ORIGIN      
        1 acatggggag cccctgggaa cacagctcat caccatggac ttgacctgga ggctcctctt
       61 tgtggtggca gcagctacag gtgcccagtc ccaggtccac ctggtgcagt ccggggctga
      121 ggtgaagaag cctggggcct cagtgaagct ctcctgcaag acttctggat acaccttcag
      181 catctctgcc atcagttggg tgcgacaggc ccctggacaa gggcttgggt ggatgggagg
      241 gatcatccct cttgttggtg tgacaaacta cgaacagaag ttccagggca gagtcacgat
      301 taccgcggac acgtccacga atacagtctt catggaactg agcagcctga gatctgagga
      361 cacggccgtc tactattgtg cgacaggggt atattaccag gatgaatacg gttattttta
      421 tgtcggcggt gactttgact actggggcca gggagtcctg gtcaccgtct ccccagcc
//
LOCUS       KCXD01003577             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19805:18673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003577
VERSION     KCXD01003577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19805:18673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62059.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       441..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          101 a          127 c          157 g          113 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca caccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccattg tgaggcgcac ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctaagact ctcctgtgaa gcctccgggt tcaccttcag tgaccactgc
      241 atgcactggg tccgccaggc ttcagggagg gggctggagt gggtctcagg tattacttat
      301 actggtgtta ccacatggta cgcagactcc gtgaggggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg tgggaggaag gcggcacgtg gaccttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003578             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:12964:15991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003578
VERSION     KCXD01003578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:12964:15991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62060.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       446..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          119 c          148 g          119 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctggaggagg cttggttcgg
      181 cctggggggt ccctgagact ctcctgttca gcctctggat tcaccttcag taattttggc
      241 atccactggg tccgccaggc tccagggaag ggcctggagt gggtggcagt tacatcgtct
      301 gatgaaagta agaaatacta tgcagactct gtgaaggacc gattcaccct ctccagagac
      361 aattccaaga atatactata tcttcaaatg aacaacctga agttggagga cacggccgtc
      421 tattactgtg cgagagacgc atatggcagc ggctgtgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003579             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19152:13578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003579
VERSION     KCXD01003579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19152:13578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62061.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          113 a          144 c          130 g           90 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt gttcatcctg aatatggtaa agtggactac
      301 acacagaagt tccgagacag actcaccatc accgcggaca tgtcgacaga gacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003580             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16997:7165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003580
VERSION     KCXD01003580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16997:7165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62062.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       453..466
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          115 a          128 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt tcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcagct tcagtgacta
      241 tggcatgagc tgggtccgcc aggcctctgg gaaaggactg gagtgggttg gctacattag
      301 aagcacacat aggaattacg cgacggaata cgccgcatcg gtgaaaggca gatgcaccat
      361 ctccagagat gactcaaaga acacactata tctgcaaatg agcagcctga gaaccgagga
      421 cacggccgtg tattactgca ccaccctcta tggtggtagt tattacgtgg actactttga
      481 ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003581             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13187:12377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003581
VERSION     KCXD01003581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13187:12377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62063.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          123 a          140 c          135 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaggtggtg cagtctgggg ctgaggtgaa gaggcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga caaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatttcctc aacc
//
LOCUS       KCXD01003582             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24331:10276
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003582
VERSION     KCXD01003582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24331:10276"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62064.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       433..439
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          138 c          148 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag taaaggtctc
      181 ctgccaggtt tccggagaca ccttcagtga aatgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt tgctcctgga aatggggaaa taatacacgc
      301 agataacttc cagggcagag tcaccatgac cgaggacacg tctatagaca cagcctacat
      361 ggagctgagt agcctgagat ctgaggacac ggccgtatat tactgtgcga gcgggacatt
      421 tgggaccagc gtctggtcca gcctcttcta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcagcgtc tcctcagcc
//
LOCUS       KCXD01003583             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15664:19272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003583
VERSION     KCXD01003583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15664:19272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62065.1"
                     /translation="CARDAGVGATILYYYDFW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          134 c          137 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcagtg tctctggtgg
      181 ctccttcagt ggttactact ggaactggat ctgccagccc ccagggaagg gactggagtg
      241 gattgggttt atcggcggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa tcaattctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgttt attactgtgc gagagatgcg ggagtgggag ccacaatcct
      421 ttattactat gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003584             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9867:8277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003584
VERSION     KCXD01003584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9867:8277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..432
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62066.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       443..448
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          103 a          126 c          156 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cacaccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccat tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctaaga ctctcctgtg aagcctccgg gttcaccttc agtgaccact
      241 gcatacactg ggtccgccag gcttcaggga aggggctgga gtgggtctca ggtattactt
      301 atactggtgt taccacatgg tacgcagact ccgtgagggg cagattcacc atctccagag
      361 agaacaccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctatttctg tgtggcagga aggcggcacg tggaccttga ctactggggc cagggagtcc
      481 tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01003585             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11787:12583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003585
VERSION     KCXD01003585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11787:12583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..339
     V_segment       8..268
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62067.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       281..289
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..339
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           70 a           95 c          100 g           76 t
ORIGIN      
        1 acatgggggt gaagcctccg gagaccctgt ccctcacctg cgctgtctct ggtggctcta
       61 tcagcagtag ttactgcagc tggatccgcc agaccccagg gaagggactg gagtggattg
      121 gctatatata tgggagtgat agtagtacca actacaaccc ctccctcaag agtcgagtca
      181 ccctgtcagt ggacacgtcc aagaaccagt gctccctgaa gctgagctct gtgaccgccg
      241 cggacacggc cgtgtatttt tgtgcgagtt cgggtataga agtggttgcg tacagcattg
      301 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003586             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:12965:7578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003586
VERSION     KCXD01003586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:12965:7578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..464
     V_segment       98..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62068.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       401..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          141 c          130 g          105 t
ORIGIN      
        1 acatggggct ctgagagtca tggacctcct gtgcaagaac atgaagcacc tgtggttctt
       61 ccttctcctg gtgtcagctc ccagatgggt cctgtcccag gtgcagctgc aggagtcggg
      121 cccaggactg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct ctggtggctc
      181 catcaccagt agcttctgga actggatccg ccagccccca gggaagggac tggagtggat
      241 tgggtctatc tatggtgcta ctgggagcac cacctacaac cccgccctca agagtcgagt
      301 caccatttca acagagacgt ccaagaacca gttttccctg agactgagct ctgtgaccgc
      361 cgcggacacc gccgtgtatt actgtgcgag atatgacgac gatgattacg gttcctatta
      421 ccttgactac tggggccagg gagtcctggt ccccgtctcg tcagcc
//
LOCUS       KCXD01003587             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11575:10542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003587
VERSION     KCXD01003587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11575:10542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62069.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       427..432
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          114 a          146 c          137 g           90 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccgctctga
      121 ggtccagctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attctccacg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgca tatggtgaaa tgacacacgc
      301 agaaaacttc cagggcagac tcaccatgac cgaggacacg tctacagaca cggcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat tattgtgcga gatcatccag
      421 cggtacgtgg ctatactggt acttcgatac ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01003588             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21305:11082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003588
VERSION     KCXD01003588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21305:11082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62070.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       423..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          141 c          143 g          104 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagt tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tcctgcaagg ctcctggata catcttcagc atatctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttgacat aacaacctac
      301 gcacagaagt tccaggacag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagtggcggc
      421 ttcgaggatg ataacggtca ctattatacg acactaacat ttcacgattg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003589             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15445:4976
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003589
VERSION     KCXD01003589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15445:4976"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62071.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          110 a          141 c          144 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg cagtgaagag gcctggggcc tcagttaagg
      181 tctcctgcaa ggtttccgga tactccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtgtatggt gaagaaatac
      301 acgcagagaa tttccaggac agagtcacca tgaccgagga cacgtccaca gacacagcct
      361 acatggagct gagcagcctg agacgtgagg acacggccgt gtatttctgt gcggcgggcc
      421 ttggggggta tttagttctt actgaatacc tcgaattctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01003590             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4414:14567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003590
VERSION     KCXD01003590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4414:14567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..498
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62072.1"
                     /translation="CARGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>502
                     /gene="IGHG"
BASE COUNT          114 a          140 c          149 g           99 t
ORIGIN      
        1 acatggggac cacacaacaa ccacatccct cgcctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaagtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 cgcctgcaag gtttccggaa acaccttcac cgaattattc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgtcgatcct gctcaaggtg aattaatata
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgagaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctctg cc
//
LOCUS       KCXD01003591             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22194:14885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003591
VERSION     KCXD01003591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22194:14885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62073.1"
                     /translation="CVRDAYGGGWDSW"
     D_segment       300..308
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           74 a           85 c          107 g           84 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agtacctctg gcatgcactg ggtccgccag gctccagggc
      121 aggggctgga gtgggtggcg gttatatcgt ttgatgatag taagaaatac tacgcagact
      181 ctgtgaagga ccgattcacc atttccagag acaattccaa gaacatgcta tatcttcaga
      241 tgaacaacct gaaattggag gacacggccc tttattactg tgtgagagat gcttacggtg
      301 gtggctggga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003592             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20559:16075
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003592
VERSION     KCXD01003592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20559:16075"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62074.1"
                     /translation="CAKGETAAVYYGLDSW"
     D_segment       434..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          132 c          149 g          109 t
ORIGIN      
        1 acatgggggg agaggagccc agcactggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cggtgtgagg tgcagctggt cgagtccggg ggcggcttgg cgaagcctgg
      181 gggatccctg agactctcct gtgcagcctc tggattcacc ttcagtacct acgccattca
      241 ctgggtccgc caggctccag ggaagggact ggagtgggtc tcagccatta gtagtggtgg
      301 cagcacattc tacgcagcct ccgtgaaggg ccgattcacc atctccagag acaattcaaa
      361 gaacacgctc tccctacaaa tgaacagcct aacaactgag gacacggcca tgtattactg
      421 tgcgaaagga gaaacagctg cagtttacta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003593             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18116:7397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003593
VERSION     KCXD01003593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18116:7397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62075.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          131 c          148 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctggctt ttccttgtta
      121 cttttttgag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgaa atgggtctca tctattagta
      301 gtggtggtct cacatactac gcagactccg tgaagggccg atttgccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag cgctgaggac acggccgtat
      421 attactgtgc gaaaggaggt agcagctctt tctattggta cttcgatatc tggggccctg
      481 gcaccccagt gatcatctcc tcagcc
//
LOCUS       KCXD01003594             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11288:13050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003594
VERSION     KCXD01003594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11288:13050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62076.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       443..448
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          112 c          155 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaaga ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gaagcctctg gattcgcctt cagtagtttt
      241 ggctttcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tacgatgaaa ataagaaata ttacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt ttatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgcgaggag gccctggagt gcagatgctt ttgatttctg gggccgagga
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01003595             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14411:4685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003595
VERSION     KCXD01003595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14411:4685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62077.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          134 c          137 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagccgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatatttgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagtgct ccctgaggct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003596             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:23590:8770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003596
VERSION     KCXD01003596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:23590:8770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62078.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       239..251
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           75 a           72 c           86 g           65 t
ORIGIN      
        1 acatggggca gtctctggat tcaccttcag tagctttggc atgcactggg tccgccaggc
       61 tccagggaag gggctggagt gggtggcagt gacatcctat gatggaagtt ggaagtacta
      121 cggagactct gtgaaggacc gattcaccat ctccagagac aattccaaga acctgctata
      181 tcttcaaatg aacagcctga aattggagga cacggccaca tactactgtg cgagagggga
      241 atacagtaac tctattgact actggggcca gggagtcctg gtcagcgtct cctcagcc
//
LOCUS       KCXD01003597             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18757:14147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003597
VERSION     KCXD01003597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18757:14147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62079.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       411..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           92 a          139 c          142 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcgggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagtaa ttggtggagc tggatccgcc agtccccagg gaagggactg
      241 gaatggattg ggggtgtcta tggtagtggt gggaataccg aatacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa ggacacgtcc aagaaccaat tctccctgaa gctgaactct
      361 gtgaccgccg cggacaccgc cgtgtattac tgtacgagag aatggggcgc tatagcggca
      421 gttgggcctg tccttgcctc ctggggccag ggtgtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003598             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19838:11074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003598
VERSION     KCXD01003598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19838:11074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62080.1"
                     /translation="CARTSGGWSPYFDFW"
     D_segment       399..414
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           89 a          142 c          131 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtaccta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tggtggtggg aacaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga cacgtccagg aaccactttt ccctgcagct gaattatgta
      361 accgccgcgg acacggccgt gtattactgt gccagaacta gcggtggctg gtccccctac
      421 tttgactttt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003599             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11064:4923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003599
VERSION     KCXD01003599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11064:4923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62081.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          110 a          117 c          156 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgacac tctcctgtgt agcctctgga ttcaccttca gtagctatgg
      241 catgggctgg gtccgccagg ctccagggaa ggggctggag tgggtgggaa ttgtttcgtt
      301 tgatggaact aagagatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaag aatatcctat atcttcaaat gaacaacctg aaatccgaag acacggccgt
      421 gctttatagt acgagagtag actgtagtgg tggtgtctgc tactttgacc actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003600             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22935:6816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003600
VERSION     KCXD01003600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22935:6816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62082.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          141 c          138 g           98 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctgggactga ggtgaggaag cctggggccg cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaag ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcaat tggctttttt ggtacttcga tttttggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003601             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:19965:18049
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003601
VERSION     KCXD01003601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:19965:18049"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62083.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          102 a          123 c          160 g          118 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagccgg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag tttcagtcac tacttcatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcagggatt aacagtggtg
      301 gggatactac ataccacgca gactccgtga agggcagatt caccatgtcc agagagaacg
      361 ccaagaacac actgtctctt caaatggacg gcctgagagc tgaggactcg gctgtctatt
      421 actgtgcgag agatcgacgt gtacagtcgt tatcttggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003602             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12259:7320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003602
VERSION     KCXD01003602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12259:7320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62084.1"
                     /translation="CARYEEGGPTFDFW"
     D_segment       409..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          136 c          134 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctt acctgcgctg tctcaggtga
      181 ctccatcacc agcagttact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gatcggatat atttatggtg gaagtgggag caccggctac aatccctccc tcaagagtcg
      301 agtcaccatt tcagtagaca cgtccaagaa ccagttttcc ctgaagctga cgtctgtgac
      361 cgccgcggac accgccgtat atttctgcgc gcgatatgaa gagggcggac ccacctttga
      421 cttctggggc cagggagtcc tggtcagcgt ctcctcagcc
//
LOCUS       KCXD01003603             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20163:2359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003603
VERSION     KCXD01003603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20163:2359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62085.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          116 c          147 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aattggtgga gtctggagga ggtttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtttctgg attcaccttc agtaactatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagact ctgttaagga ccgattcacc atctccagag
      361 acaattctaa caacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgaggcgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003604             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21490:13618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003604
VERSION     KCXD01003604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21490:13618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62086.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          112 c          147 g          123 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc gttcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtgca attggtggag tctggaggag gcttgattca
      181 gcctgggggg tccctgaggc tctcctgtgc agcctctgga ttcaccttca gtaattatgg
      241 cttgcactgg gtccgccagg ctccagtgaa ggggctggag tgggttgcag ttatatcgta
      301 tgatgaaaat gtgaaatact acgcagactc tgtaaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagggg aatacagtaa ctctattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003605             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13870:17237
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003605
VERSION     KCXD01003605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13870:17237"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62087.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          116 c          147 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aattggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacacaaact ctgtgaagag ccgattcacc gtctccagag
      361 acaattccca gaacatactt tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatcttggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003606             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21163:11334
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003606
VERSION     KCXD01003606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21163:11334"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62088.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       258..263
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           77 a           80 c           86 g           77 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaaactttg
       61 gcatacactg ggtccgccag gctccaggga agggcctgga gtgggtggca gtcatttcgt
      121 ctgatggaac taagatatac tacgcaaact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatacta tatcttcaaa tgagtaacct gaaattggag gacacggccg
      241 tctattactg tgcgagagat gatcttggga ccggttttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003607             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13175:8676
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003607
VERSION     KCXD01003607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13175:8676"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..454
     V_segment       100..392
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62089.1"
                     /translation="CASGRRQLDLDYW"
     D_segment       404..410
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           86 a          142 c          128 g          100 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctacacct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtctgtca cctgcgctgt ctctggtggc
      181 tctatcagca cttactactg gaactggatc cgccaggccc cagggagggg acttgactgg
      241 attggacata tctatggtag tggtgatggc accaactaca acccctccct ccagagtcga
      301 gtcaccctgt cagttgacac gaccaagaac catttctccc tgaccctgag gtctgtgacc
      361 gccgcggaca cggccgtcta ttactgtgcg agcggtcggc ggcaactgga ccttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003608             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20073:13440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003608
VERSION     KCXD01003608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20073:13440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62090.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          139 c          133 g           95 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagg tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01003609             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20871:16870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003609
VERSION     KCXD01003609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20871:16870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..483
     V_segment       117..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62091.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       415..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          124 a          141 c          130 g           90 t
ORIGIN      
        1 atggggacac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccagctggt gcagtctggg gctgaagtga ggaagcctgg ggcctcagtg aaggtctcct
      181 gcaaggtttc cggatacaga ttcaccgaat catccataca ctgggtgcga caggcccctg
      241 gaaaagggct tgaatggatg ggaagtgttg atcctgaata tggtgaaatg ataaacacag
      301 agaaattcca gggcagagtc accctgaccg aggacacgtc tacagacaca gcctacatgg
      361 atctgaacac cctgagatct gacgacacgg ccatctatta ctgtgcgaga gcccatagcg
      421 gcagctggaa taactggtac ttcgatctct ggggccctgg caccccaatc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003610             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14837:4804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003610
VERSION     KCXD01003610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14837:4804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62092.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          117 a          112 c          150 g          129 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg tggagcagtt ggtggaatct gggggaggat tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagta gctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctggagtgg gtatcaggta ttaacattgg
      301 cggtgacaca tactacccag actctgtgaa gggtcgattc actatctcca gagacaatgc
      361 caagaactcc gtgtatcttc aaatgaacag cctgagagtt gaggacactg ctgtgtattt
      421 ttgtgcaagg gggatagata actaccactt tagtaatacg gagtttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003611             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18085:8042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003611
VERSION     KCXD01003611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18085:8042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62093.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       443..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          112 c          152 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcacc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt agttatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgtaagtaa gaaatactac gcagacgctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa caccctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgg gagagatgat aatggggtgc ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003612             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10759:6592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003612
VERSION     KCXD01003612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10759:6592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62094.1"
                     /translation="CARDVRGTGFDFW"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          115 c          154 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 ccgcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 atatattact gtgcgagaga tgtcaggggc acggggtttg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003613             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:25286:5957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003613
VERSION     KCXD01003613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:25286:5957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..454
     V_segment       100..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62095.1"
                     /translation="CARWSAANFDYW"
     D_segment       401..407
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           87 a          137 c          134 g           98 t
ORIGIN      
        1 catgggggtt ctctgagagt cacggacctc ctgggcaaga acatgaagca tctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcaact gcaggagtcg
      121 ggcccaggac tggtgaagcc ctcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcaaca gtggttatgg ctggagctgg gtccgccagc ccccagggaa ggggctggag
      241 tggattgggt gtctctatga tagtagtggg aacacgtact acaacccctc cctcaagagt
      301 cgcgtcacca tttcaaaaga cacgtccaag aaccagttct ccctgaacct gaggtctatg
      361 accgccgcgg acacggccgt ctattactgt gcgagatggt cggcagccaa ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003614             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8901:13510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003614
VERSION     KCXD01003614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8901:13510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62096.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       419..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          141 c          134 g           94 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag gagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctggg aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 acacacagag ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctaa gatcagagga cacggccctg tattactgtg cagtcggata
      421 tagcggcaga tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003615             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7667:14827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003615
VERSION     KCXD01003615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7667:14827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..452
     V_segment       98..394
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62097.1"
                     /translation="CARWSAANFDLW"
     D_segment       399..405
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       408..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           88 a          133 c          134 g           99 t
ORIGIN      
        1 atgggggttc tctgagagtc acggacctcc tgggcagaac atgaggcatc tgtggttctt
       61 cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcaactgc aggagtcggg
      121 cccaggactg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct ctgggggctc
      181 catcaacagt ggttatggct ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtgt atctatgata gtagtggaaa cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaaaagaca cgtccaagaa ccagttctcc ctgaatctga ggtctatgac
      361 cgccgcggac acggccgtgt attactgtgc gagatggtcg gcagccaact ttgacctctg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003616             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12725:13513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003616
VERSION     KCXD01003616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12725:13513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62098.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       447..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttctttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatttctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggca gttaaatcgt
      301 ttgatggaac taagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagac gcctacggga gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003617             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14068:14689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003617
VERSION     KCXD01003617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14068:14689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62099.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          105 a          118 c          162 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctcc ggtattaata
      301 gtggtgggga tactacatac tacgcagact ccgtgaaggg ccgattcacc atgtccagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003618             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17059:2960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003618
VERSION     KCXD01003618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17059:2960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..482
     V_segment       107..400
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62100.1"
                     /translation="CARDPIVAAGTGRYWYFDLW"
     D_segment       406..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           93 a          139 c          145 g          107 t
ORIGIN      
        1 acatggggag atgtgagtgt ctcggggatg cagatatgac gacatgggag gttgtctctg
       61 atcccagggc tcactgtggg tctctctgtt cacaggggtc ctgtcccagg tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc
      181 tggtggctcc atcagcagaa actactggaa ctggatccgc cagcccccag ggaaggagct
      241 ggagtggatt ggacgcatct atggtagtgg tgggggctcc gactacaacc cctccctcaa
      301 gagtcgactc accatttcaa cagacgcgtc caagaaccag tttttcctga ggctgagctc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ttgtgcgaga gatcctatag tggcagctgg
      421 aactggtcgc tactggtact tcgatctctg gggccctggc accccaatca ccatctcctc
      481 agcc
//
LOCUS       KCXD01003619             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4640:8448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003619
VERSION     KCXD01003619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4640:8448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62101.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       445..451
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          146 c          141 g          101 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgatga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacaccctc agcatctctg ccatcagttg ggtacgacag
      241 gcccctggac aagggcttga gtggatggga gagatcttcc ctcttgttgg tgtgacaaaa
      301 tacgcacaga acttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc
      361 tacatggagc tgcgcggcct gagatctgag gacacggccg tatattactg tgcgagaaga
      421 ggtggccacg gtaccaccac cacgttgtac ttctttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003620             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13525:13849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003620
VERSION     KCXD01003620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13525:13849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62102.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       404..417
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           90 a          134 c          141 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacttgcgt tgtctctggc
      181 cactccatca gcagtggcta ccactggggc tggatccgtc agcccccagg gaagggactg
      241 gactatattg gctatatcag tggtagtagt gggagcacct actccaagcc ctccctcatg
      301 agtcgagtca tcatttcaag agacacgtcc cggaatgagt tctccctgag gctgaggtct
      361 gtgactgtcg cggacacggc cgtgtattat tgtgcgagac gagatagctg gaacaacggg
      421 gggagccttg actactgggg ccagggattc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003621             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14144:16154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003621
VERSION     KCXD01003621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14144:16154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62103.1"
                     /translation="CVRGMDNYRYINTDFDYW"
     D_segment       443..449
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          121 c          148 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggtccgcca ggctccaggg aagggtctgg agtgggtttc aggtattaac
      301 attggcgatg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacaacctga gagctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cgctacatta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003622             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:19404:9729
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003622
VERSION     KCXD01003622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:19404:9729"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62104.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       442..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          113 c          154 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg tcgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtggagcctc tggattcacc ttcagtacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcggttatat cgtttgatga
      301 tagtaagaaa tactactcag actctgtgaa ggaccgattc accatttcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ctgtgtgaga gatgcttacg gtagtggctg ggactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003623             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9397:6671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003623
VERSION     KCXD01003623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9397:6671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62105.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       440..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          113 c          156 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcggcct ctggattcac cttcagaacc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcggttata tcgaatgatg
      301 aaactaacaa atactacgga gactctgtga agggccgatt cagcatctcc agagacaatt
      361 cgaagaacat gctatatctt caaatgaaca ccctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgac agatgcgttt ggtagtggga ttgaccactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003624             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12173:6708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003624
VERSION     KCXD01003624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12173:6708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..494
     V_segment       128..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62106.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       433..439
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..494
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          123 a          140 c          138 g           95 t
ORIGIN      
        1 acatggggga gagcatcaca caacaaccac atccctcccc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag cgacaggcgc
      121 ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaaggtctcc tgcaaggttt ccggatacat cttaaccgaa ttatccatgc actgggtgcg
      241 acaggcccct ggaaaagggc ttgagtggat gggaagtgtt gatcctcaat atggtgaaat
      301 gatagacgca gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac
      361 agcctacatg gagctgagca gtctgagatc tgaggacacg gccgtgtatt actgtgcgac
      421 atcatccagc ggcacctggc tatattggta cttcgatatc tggggccctg gcaccccaat
      481 caccatctcc tcagcc
//
LOCUS       KCXD01003625             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19559:7640
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003625
VERSION     KCXD01003625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19559:7640"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62107.1"
                     /translation="CARDVWGRGFDFW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          110 c          158 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcggctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaactaagaa gtattatgca gactctgtga aggcccgatt caccgtctcc agagacaatt
      361 ccaagaacat gttatatctt caaatggaca acctgaaatt ggaagacacg gccgtgtatt
      421 attgcgcgag agatgtctgg gggaggggat ttgacttttg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003626             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16505:14005
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003626
VERSION     KCXD01003626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16505:14005"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62108.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       414..419
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..468
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           91 a          142 c          133 g          104 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggggt
      121 cgggcccagg gctggtgaag ccttcggaga ccctgtccct cacctgcgct gtttctggtg
      181 actccatcaa cagtggctac tactggagtt ggatccgcca acccccaggg agggggctgg
      241 agtggattgg gtctatcggt ggtagtagtg gcagcaccta ctacaacccc tccctcaaga
      301 gtcgagtcac cctttcaaaa gacacgtcca ggaaccagtt ctccctgaaa ctgagctctg
      361 tgaccgccgc agacacggcc gtttattact gtgcgagaaa acttccaggt ctccaactaa
      421 ccggtttcga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003627             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13219:14259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003627
VERSION     KCXD01003627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13219:14259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62109.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       406..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           98 a          134 c          129 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctatg gtagtactgg gagcaccggc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagt tgaactctgt
      361 gatcgccgcg gacaccgccg tgtattactg tgcgagatat ggagatgata gtgttcatta
      421 caactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003628             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9962:16816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003628
VERSION     KCXD01003628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9962:16816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..439
     V_segment       76..368
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62110.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       381..389
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           87 a          126 c          131 g           97 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccagct gcagctgcag gagtcgggcc caggactggt gaagcctccg
      121 gagaccctgt ccctcacctg cgctgtctct ggtggctcta tcagcagtag ttactgcagc
      181 tggatccgcc agaccccagg gaagggactg gagtggattg ggtatatatt tgggagtgat
      241 agtagtacca actacaaccc ctccctcaag agtcgagtca ccctgtcagt agacacgtcc
      301 aagaaccagt gctccctgag gctgagctct gtgaccgccg cggacacggc cgtgtattat
      361 tgtgcgagtt cgggtataga agtggttgcc tacagcattg actactgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003629             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12592:13217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003629
VERSION     KCXD01003629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12592:13217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62111.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       404..408
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          100 a          108 c          140 g          117 t
ORIGIN      
        1 acatgggcag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgtttctatt ttaagaggtg tccagtgtga ggtgcagctg
      121 gtggagtctg gaggaggctt ggttcagcct ggggagtccc tgagactctc ctgtgcagcc
      181 tctggattca ccttcagtag ctctggcatg cactgggtcc gccaggctcc agggaagggg
      241 ccggagtggg tgtctgtaat ttcgtctgat ggaagtaaga aatactacgc agactctgtg
      301 aaggaccgat tcaccatctc cagagacaac tccaagaaca tactatatct tcaaatgaac
      361 aacctgaaat tggaggacac ggccgtgtat ttctgtgtga gagatgcctt cgggggcggt
      421 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003630             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19878:12856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003630
VERSION     KCXD01003630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19878:12856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62112.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       434..441
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          122 a          141 c          140 g           97 t
ORIGIN      
        1 atggggatca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agccacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgaag ttaagaagcc tggggcctca gtgatggtct
      181 cctgccaggt ttccggatac accgtcaccg aaatatccat gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaagtg ttgctcctga aaaaaatgag ttaatacacg
      301 cagacaagtt ccaggacaga gtcagcatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag tggcctgaca tttgaggaca cggccgtgta ttactgtgcg acccacggag
      421 gttatagcga catctggaac tccctatata acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003631             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:7671:15906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003631
VERSION     KCXD01003631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:7671:15906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..462
     V_segment       81..379
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62113.1"
                     /translation="CVRSVPFFEDDYGYFPYFDFW"
     D_segment       392..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           93 a          139 c          117 g          115 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tccacgctcc tgctgcaccg
       61 tcccgtcctg ggtcttgtcc caggtgacct tgaaggagtc tggtcctgcg ctggtgaaac
      121 ccacacagac cctcacgctg acctgcgcct tctctgggtt ctcactcagc actagtggtt
      181 tgggtgtggc ctggatccgt cagccctcac ggaagaccct ggagtggctt gcacacatta
      241 attggaatga tgatgagcgc tacaatacat ctctaaagag taggctcacc atctccaagg
      301 acaccgccat aaaccaggtg gttctgacaa tgaccaacat ggaccctgtg gacacagcca
      361 catattactg tgtacggagt gtcccgtttt tcgaggatga ttacggttac tttccttact
      421 ttgacttctg gggccaggga gtcctggtca ctgtctcctc agcc
//
LOCUS       KCXD01003632             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9494:15684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003632
VERSION     KCXD01003632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9494:15684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62114.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       452..463
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          120 a          126 c          152 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccagttggc
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc ggtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgactt
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aaccaaatat aacaattacg cggcagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaaga acacgatata tctgcaaatg agtagcctga aaaccgagga
      421 cacggccgtg tattactgca ccacatggag atattactat agtactggtt accccacctt
      481 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003633             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9789:11039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003633
VERSION     KCXD01003633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9789:11039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62115.1"
                     /translation="CARGVDNHHYSDTEFDLW"
     D_segment       451..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          120 c          149 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggagtctg ggggaggctt ggtacagccg
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtgga tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcggttca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacagc ctgagagctg aggacactgc tgtatattat
      421 tgtgcaagag gcgtagataa ccaccactac agtgatacgg agtttgacct ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003634             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19952:13712
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003634
VERSION     KCXD01003634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19952:13712"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62116.1"
                     /translation="CARRKYSGYTYGGANFDFW"
     D_segment       404..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           98 a          133 c          148 g          100 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg agggcttcgg aggccctgtc cctcacctgc actgtctctg
      181 gtggctccat gagcggttac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gggtatcggt ggtggtagtg ggagcaccga ttacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaga gacacgtaca agaaccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcaagaag gaaatacagc gggtacacgt
      421 acggaggggc gaactttgac ttttggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003635             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:25975:15057
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003635
VERSION     KCXD01003635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:25975:15057"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62117.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          118 c          161 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctcc ggtattaata
      301 gtggtgggga cactacatac tacgcagact ccgtgaagag ccgattcacc atgtccagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggatttctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003636             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:26924:8238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003636
VERSION     KCXD01003636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:26924:8238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62118.1"
                     /translation="CAREDYGNYEGSEFFEVW"
     D_segment       398..412
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..470
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          141 c          136 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atttctggta ttggtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagttga ggtctctgac
      361 agccgcggac acggccgtgt attactgtgc gagagaagac tacggtaact acgaagggtc
      421 agaattcttc gaggtctggg gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003637             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:28289:14603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003637
VERSION     KCXD01003637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:28289:14603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..469
     V_segment       91..384
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62119.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       388..407
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           96 a          129 c          143 g          103 t
ORIGIN      
        1 acatgggggc ccctgggaac acagctcatc accatggact tgacctggag gctcctcttt
       61 gtggtggcag cagctacagg tgcccagtct caggtccagc tggtgcagtc cggggctgag
      121 atggagaagc ctggggcctc agtgaagctc tcctgtaagg cttctggata caccttcagc
      181 atctatgtca tcagttgggt gcgacaggcc cctggacaag ggcttgagtg gatgggaggc
      241 atcttccctc ttgttggtac aacaaactac gcacagaagt tccagggcag agtcacgatt
      301 accgcggaca cgtccacaag cacagcctac atggacctga gcagcctggg atctggggac
      361 acggccgtgt attattgtgc gagaggttac tgtactggta gtggttgtaa ccttacattc
      421 aaccggctcg atgtctgggg cccgggagtc ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01003638             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9412:10900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003638
VERSION     KCXD01003638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9412:10900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62120.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          113 c          150 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg agggggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttctt tcatctgatg
      301 gaagtaagaa atactacgca aactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat agtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatg gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003639             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12481:16164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003639
VERSION     KCXD01003639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12481:16164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62121.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..410
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           85 a          134 c          140 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga cttgtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttattact ggggctggat ccgccagccc ccaggggagg ggctggagtg
      241 gattgggtat atcagtggga gtggtgggag taccgactac aagtcttccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga ggtctctgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003640             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:17592:6518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003640
VERSION     KCXD01003640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:17592:6518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62122.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccca gaacatggta tatcttcaaa tgaacaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003641             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15310:2858
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003641
VERSION     KCXD01003641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15310:2858"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..469
     V_segment       100..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62123.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       400..410
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           95 a          140 c          134 g          102 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tgctgaagcc tttggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagca gtaactactg gagctggatc cgccagtccc cagggaaggg actggagtgg
      241 attggacgta tctctggtag tggtgggaac accgtctaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cagatctccc tgaaagtgac ctctgtgacc
      361 gccgcggaca cggccgtgta ttattgtgcg acagccggat atagcagcag ggaaagcttc
      421 tacggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01003642             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:26530:15409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003642
VERSION     KCXD01003642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:26530:15409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62124.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          109 c          152 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgcgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaaa tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaatat ggtatatctt caagtgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatttg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003643             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24355:20571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003643
VERSION     KCXD01003643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24355:20571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62125.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          116 a          113 c          154 g          116 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaact aagaagtact acggagactc tgtgaaagac cgattcacca tctccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 atattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01003644             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17731:13273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003644
VERSION     KCXD01003644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17731:13273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62126.1"
                     /translation="CARSQSYCRGLYCYGYYYFDFW"
     D_segment       406..429
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           97 a          145 c          133 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcaa ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctatcacc agtactaagt ggtggagctg gatccgccag ccaccaggga aagggctgga
      241 gtggatcggg tatattagtg gtagcagtgg taccacctac taccacccct ccctcaagag
      301 tcgagtcagc atttcaacag acacgtccaa gaaccacttc tccctggagc tgaactctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatcc caatcatatt gtcgtggtct
      421 ttactgctac ggctactact actttgactt ctggggccag ggagtccagg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003645             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:11458:8364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003645
VERSION     KCXD01003645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:11458:8364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62127.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       437..442
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          112 c          147 g          118 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agccgggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg gcatccactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt atgatgaaac
      301 aaagaaatac tacgcagact ctctgaagga ccgcttcatc atctccagag acaattccaa
      361 gaacatggta tatcttcaaa tgaataacct gaaattggat gacacggccg tatattactg
      421 tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggtgtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003646             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11499:22495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003646
VERSION     KCXD01003646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11499:22495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62128.1"
                     /translation="CAGGSRRQPENW"
     D_segment       405..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           84 a          132 c          139 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctatgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatcggtgg tactagtggg agtacctact acaatccctc cctcgagagt
      301 cgagtcacca tttcaacaga cacgtccaag aatctcttct ccctgaagat gagttcttta
      361 accgccgcgg acacggccat gtatttctgt gcgggcggaa gtcggcggca gccggagaac
      421 tggggccagg gagtcctggt caccgtctct tcagcc
//
LOCUS       KCXD01003647             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:11528:6448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003647
VERSION     KCXD01003647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:11528:6448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..264
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <256..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62129.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       270..275
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..325
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           77 a           77 c           96 g           77 t
ORIGIN      
        1 acatgggagc cgggggggtc cctgagactc tcctgtgcag cctctggatt cagcttcagt
       61 ggctttggca tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt
      121 atatcgtatg atgaaactaa gaaatattac gcagactctg tgaaggaccg attcaccgtc
      181 tccagagaca attccaagaa catgctatat tttcaaatga acaacctgaa attggaagac
      241 acggccgtat attactgtgc gagagatgtc tatggcaggg gacttgactt ctggggcctg
      301 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003648             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:13612:15725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003648
VERSION     KCXD01003648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:13612:15725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62130.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       424..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           94 a          147 c          144 g          110 t
ORIGIN      
        1 acatggggtc tccctcaccg cacagctggg atctcagtgc ttccttttct gtcctccacc
       61 acgatggggt caactgccat cctcaccctc ctactggctg ttctccaagg agtctgtgcc
      121 gaggtgcagc tggtgcagtc tggagcagag gtgaaaaggc ccggggagtc tctgaagatc
      181 tcctgtaaga cttctggaga cacctctacc tactattgga tcagctgggt gcgccagatg
      241 cccgggaaag gcctggagtg gatgggggcg attgatcctg gtgattctga taccaaatat
      301 agtccgtcct tccaaggcca ggtctccatc tcagccgaca agtccatcag caccgcctac
      361 ctgcagtgga gcagcctgaa ggcctcggac accgccacgt attactgtgc gaaagggggg
      421 tggtggggtg attatccacc ctcagactgg ctcgatgtct ggggcccggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003649             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5975:15547
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003649
VERSION     KCXD01003649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5975:15547"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62131.1"
                     /translation="CASGPSGTWNDWYFDIW"
     D_segment       429..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          146 c          136 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaactgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga ctggatggga agtgttgatc ctctatatgg tgaaatgata
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaccagcct gagatctgag gacacggccg tgtattattg tgcgagtggc
      421 cctagcggca cctggaacga ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003650             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:2907:7893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003650
VERSION     KCXD01003650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:2907:7893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62132.1"
                     /translation="CVRDTFGSGFDYW"
     D_segment       432..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          115 c          145 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctccc gggaagggtc tggagtgggt agcagttatc tcccatgatg
      301 agaataatat atattacgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacaa cgtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtttt
      421 actgtgtgag agatacattc ggttcagggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003651             374 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16790:3976
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003651
VERSION     KCXD01003651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 374)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 374)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16790:3976"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..372
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..372
     V_segment       1..284
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <276..>341
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62133.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       289..293
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       328..372
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        373..>374
                     /gene="IGHG"
BASE COUNT           75 a          113 c          104 g           82 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg
       61 tctctggtgg ctccttcagc acttcctact ggagctggat ccgccaggcc ccagggaagg
      121 gactggagtg gattggatat atctatgctg atagtgggac caccagctac aacccgtccc
      181 tcaagagtcg agtcaccatt tcaatagaca cgtccaagaa tctgtactcc ctgaaactga
      241 gctctgtgac cgccgcggac acggcctttt attactgtgc gagacgtcct actcgcacgc
      301 gggttctata tgaggcgaca ggggaagact ttgactcctg gggccaggga ctcctggtca
      361 ccgtctcctc agcc
//
LOCUS       KCXD01003652             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18585:10468
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003652
VERSION     KCXD01003652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18585:10468"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62134.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       424..431
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          105 a          139 c          145 g           98 t
ORIGIN      
        1 acatggggga cataacaacc acctccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ctgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga tgtgaagaag cctggggcct cagtgaaact
      181 ctcctgcaag gcttctggat tcgccttcag aatgtatgcc ctcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gatcgtcccg cttgttggaa caacaaactc
      301 cgcacagaag ttccagggca gagtcacgat taccgcggac acgtccataa gcacagtcta
      361 catggaactg agcagcctga gatctgagga cacggccgtg tattactgtg cgagaggcct
      421 gggtagcagc gcccactttg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003653             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18697:13761
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003653
VERSION     KCXD01003653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18697:13761"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62135.1"
                     /translation="CARGTGAILVYFDHW"
     D_segment       434..440
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          123 c          151 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgaga tacaactggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ctcagatact actatatgac
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtgatgg
      301 gagtagcaca tactatgcag actccgtgaa ggacagattc accatctcca gagacaacgc
      361 caagaacaca ctgtctcttc aaatggacag cctgacagct gaggacacgg ctgtctatta
      421 ttgtgcgagg gggactgggg cgattcttgt gtactttgac cactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003654             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:17464:18138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003654
VERSION     KCXD01003654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:17464:18138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62136.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       435..440
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          110 c          151 g          119 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaagt gcagctggtg gagtctggag gaggcttggt tcagccgggg
      181 gggtccctga gactctcctg tgcagcctct ggattcagct tcagtggctt tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtatgatgaa
      301 actaagaaat attacgcaga ctctgtgaag gaccgattca ccgtctccag agacaattcc
      361 aagaacatgc tatattttca aatgaacaac ctgaaattgg aagacacggc cgtatattac
      421 tgtgcgagag atgtctatgg caggggactt gacttctggg gcctgggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003655             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18952:8183
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003655
VERSION     KCXD01003655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18952:8183"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..475
     V_segment       106..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62137.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       406..417
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          100 a          139 c          134 g          104 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactgct gaagcctttg gagaccctgt ccctcacctg cgctgtttct
      181 ggtggctcca tcagcagtaa ctactggagc tggatccgcc agtccccagg gaagggactg
      241 gagtggattg gacgtatctc tggtagtggt gggaacaccg tctacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccaga tctccatgaa agtgacctct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgacag ccggatatag cagcagcgaa
      421 agcttctacg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003656             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14598:10843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003656
VERSION     KCXD01003656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14598:10843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..520
     V_segment       145..438
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62138.1"
                     /translation="CARNSYYYDIGYYYYGLDSW"
     D_segment       445..467
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..520
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          112 a          124 c          156 g          130 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg caactggagg agtcaggggg aggcttggtc
      181 cagcctggag ggtccctgag actctcctgt gtagcctcag gattcacctt cagtaattac
      241 gacatgagct gggtccgcca ggctccggga aaggggctgg agtgggtctc atatgtcagt
      301 tacactggtg gaaccatata ctacgctgac tccgtgaagg gccggttcac cgtctctaga
      361 gacgacgcca agaactcgct gtctctgcaa atgtgcagcc taagagccga ggacacggcc
      421 gtgtattact gtgctagaaa ttcctattac tatgatattg gttattatta ttatggtttg
      481 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003657             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23568:6252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003657
VERSION     KCXD01003657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23568:6252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..505
     V_segment       133..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62139.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       443..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          107 a          121 c          153 g          126 t
ORIGIN      
        1 acatggggag acaggagtct tagccctgga ttccaagaac ttccactttg ggatcagctc
       61 tgaacacaga ggaccatgga gttggggctg agctgggttt tccttgttgc tattttaaaa
      121 ggtgtccagt gtgaggtgga gctggtggag tctgggggag gcttggtcca gcctgggggg
      181 tccctgagac tctcctgtgt agcctctgga ttcacctttg gtgattatgg catgcactgg
      241 gtccgccagg ctccgggaaa gggactggag tgggtctcat ccattagaaa cactggtaaa
      301 atcgtatact acgctgactc cgtgaagggc cgattcatca tctccagaga caacgccaag
      361 aattcgctgt ctctgcaaat gaacagcctg agagtcgagg actcggccgt ctattactgt
      421 actagaattg gcgtcggatc tctagcaccg gctggtgaat actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003658             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:21890:11199
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003658
VERSION     KCXD01003658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:21890:11199"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62140.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          115 c          157 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtggt
       61 cagcacagaa cacagaggac tcaccatgaa atttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc ggcctctgga ttcaccttca gtacctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgaa
      301 tgatgaaact aagaaatact acggagactc tgtgaagggc cgattcagca tctccagaga
      361 caattcgaag aacatgctat atcttcaaat gaacaccctg aaattggagg acacggccgt
      421 gtattactgt gcgacagatg cgtttggtag cgggattgac cactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003659             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11694:19154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003659
VERSION     KCXD01003659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11694:19154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..432
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62141.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       439..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          120 c          156 g          118 t
ORIGIN      
        1 acatgggggg agagaggagc cttagccctg gatttcaagg cacttccacc tggggatcag
       61 cactgaacac agaggaccca ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggaggct tggtccagcc
      181 tggagggtct ctgagactct cctgtgtagc ctctggattc agcttcagaa gttacgaaat
      241 gagttgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagtcacac
      301 tggtgaaacc atataccacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccctata
      421 ttactgtact agaaaccgga atactgtaat gattgggtgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003660             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20528:5446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003660
VERSION     KCXD01003660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20528:5446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62142.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          138 c          139 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaggta caggcgccca
      121 ctctgaggtc cagctggtgc agtcgggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtttttg gtgaaataat
      301 gaattcagag aagttccagg gcagagtcgc cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat attggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01003661             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15162:8755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003661
VERSION     KCXD01003661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15162:8755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62143.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       418..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          140 c          141 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agccaggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtgggg ggtgttgatc ctgtatatgg tgaaatgata
      301 cacgtagaga agttccaggg cagagtctcc ttgaccgagg acacgtctac agccacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtttctctg tgcagccggg
      421 tatagtggca gctggaactc ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003662             279 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13904:14479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003662
VERSION     KCXD01003662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 279)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 279)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13904:14479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..277
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..277
     V_segment       12..199
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <193..>246
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62144.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       208..219
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       228..277
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        278..>279
                     /gene="IGHG"
BASE COUNT           58 a           81 c           83 g           57 t
ORIGIN      
        1 acatgggggg cctggatccg ccagccccca gggaagggac tggagtggat tggacgtatc
       61 tctggtagtg gtgggagcac cgtctacaac ccctccctca agagtcgagt caccatttca
      121 actgacacgt ccaagaacca ggtctccctg aaagtgactt ctgtgaccgc cgcggacacg
      181 gccgtgtatt actgtgcgac agccggatat agcagcagcg aaagcttcta cggtttggat
      241 tcctggggcc aaggggtcgt cgtcatcgtc tcctcagcc
//
LOCUS       KCXD01003663             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22203:7109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003663
VERSION     KCXD01003663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22203:7109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62145.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01003664             435 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18518:8410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003664
VERSION     KCXD01003664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 435)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18518:8410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..433
     V_segment       79..358
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <352..>402
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62146.1"
                     /translation="CAIGPSGNWNGWSFDVW"
     D_segment       366..381
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       384..433
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>435
                     /gene="IGHG"
BASE COUNT           89 a          119 c          135 g           92 t
ORIGIN      
        1 acatggggac agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca
       61 gctacaggcg cccactctga ggtccttctg gtgcagtctg gggctgaggt gatgcagcct
      121 ggggcctcag tgaaggtctc ctgcaaggtt tccggataca ccttcaccga actgtccatg
      181 cactgggtgc gacaggcccc tggaaaaggg cttgagtggg tgggaagtgt tgatcctgca
      241 tatggtgaaa tggtgttcca gggcagagtc accatgaccg aggacacgtc tatagacaca
      301 gcctatatgg agttgagcag cctgagatct gaggacacgg ccgtgtatta ctgcgcgatt
      361 ggccctagcg gcaactggaa cggctggtcc ttcgatgtct ggggacctgg caccccaatc
      421 accatctcct cagcc
//
LOCUS       KCXD01003665             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:25107:18126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003665
VERSION     KCXD01003665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:25107:18126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62147.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          113 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003666             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21226:16163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003666
VERSION     KCXD01003666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21226:16163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62148.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          141 c          130 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagttggta cagtctgggg ttgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccagtcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01003667             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12195:13687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003667
VERSION     KCXD01003667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12195:13687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62149.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       267..272
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           79 a           77 c           92 g           72 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
       61 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      121 atgatgaaac taagaaatac tacgcagact ccgtgaggga ccgattcacc atctccagag
      181 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      241 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003668             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15514:16184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003668
VERSION     KCXD01003668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15514:16184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62150.1"
                     /translation="CARVRGVNIHYFDYW"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           82 a          148 c          137 g           98 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttactc ctggagctgg atccgccagc ccccaggcaa gggtctggag
      241 tggattggac atgtcagtgg tagtagtggg agcaccgact accacccctc cctcaagagt
      301 cgagtcaccg tttcaacaga cacgtccaag cgccagttct ccctgaggct gatctctgtg
      361 accgccgcgg acacggccgt ctatcactgt gcgagagtcc ggggcgttaa catccactac
      421 tttgactact ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01003669             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7013:18499
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003669
VERSION     KCXD01003669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7013:18499"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62151.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          113 c          153 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003670             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15823:10607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003670
VERSION     KCXD01003670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15823:10607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62152.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       415..422
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          137 c          150 g          105 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctat agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacg ttcagcatct atgccatcag ttgggtgcga caggcccctg
      241 gacaagggct tgagtggatg ggagggatca tccctcttgt tgatataaca aactacgcac
      301 agaggttcca gggcagagtc acgatttccg cggacacgtc cacaagcaca gcctacatgg
      361 agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgagg ggagattgta
      421 ctgatactga ctgctcttcc gcggggggcg cctttgattt ctggggccaa gggctcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01003671             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:21598:18432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003671
VERSION     KCXD01003671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:21598:18432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62153.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          141 c          137 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccaggaaa ggggctggag
      241 tggattgggt ttttcggtgg ttatggtggg agcacctact acaacccctc ccgccagagt
      301 cgagtcacca tttcagccga cacgtccaaa caccagttct ccctgatact gacctctgtg
      361 accgccgcgg acacggccct ctactattgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003672             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:7424:16204
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003672
VERSION     KCXD01003672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:7424:16204"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..472
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62154.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       419..424
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          110 a          135 c          137 g           92 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata cagcttcaac atcgatgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgtcggtat aacaaactac
      301 gcacagaagt tccagggcag agtctcgatt accgcggaca cgtccacaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gatccaaggg
      421 aacagccagt ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003673             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:23103:13554
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003673
VERSION     KCXD01003673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:23103:13554"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62155.1"
                     /translation="CVKGETAAAYYGLDSW"
     D_segment       435..440
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          122 c          151 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaaacctg
      181 ggggatccct gagactctcc tgtacagcct ctggattcac cttcaatact tattctatgc
      241 attgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctgtt agtagtagtg
      301 ggagcacata ctacgcagac tccgtgaggg gccgatgcac catctccaga gacaactcaa
      361 agaacataat ctccctgcaa atgaacagcc tgagaactga ggacacggcc ctatattact
      421 gtgtgaaagg agaaacagct gcagcatact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003674             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13068:18171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003674
VERSION     KCXD01003674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13068:18171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62156.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          128 a          144 c          131 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgag gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacagat tcaccgaatc atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gaatggatgg gaagtgttga tcctgaatat ggtgaaatga
      301 taaacacaga gaaattccag gacagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga tctgaacacc ctgagatctg acgacacggc catctattac tgtgcgagag
      421 cccatagcgg cagctggaat aactggtact tcgatctctg gggccctggc accccaatca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003675             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7250:13562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003675
VERSION     KCXD01003675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7250:13562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62157.1"
                     /translation="CAAQIHSGGWSGRFDVW"
     D_segment       431..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          135 c          146 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcctggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atatgccttc acagaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggca ggtgttgatt ctgaatatgg tgaaatgatt
      301 gacgcggaga cgttccagga cagagtcacc atgaccgacg acacgtctac agatacagcc
      361 tacatggagt tgagtagcct gagatctgag gacacggccg tgtattactg tgctgcccaa
      421 attcatagtg gcggctggtc tgggcggttc gatgtctggg gcccgggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003676             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10979:8073
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003676
VERSION     KCXD01003676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10979:8073"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62158.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          118 a          139 c          130 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagctcct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga agtaaagggg cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggagg ttttggtcct gtatatggtg aaataataca
      301 cacagagaag ttccagggca gagtcagtat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtc tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01003677             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14378:10710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003677
VERSION     KCXD01003677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14378:10710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62159.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          114 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga agacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctactttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 atgatgaaac taagaaattt tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tgtatttctg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003678             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:10760:9550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003678
VERSION     KCXD01003678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:10760:9550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..510
     V_segment       135..428
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62160.1"
                     /translation="CTRVKYYYDSGYYVGPFDYW"
     D_segment       435..458
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          109 a          126 c          145 g          132 t
ORIGIN      
        1 acatggggag gagccacagc cccgggattc ccagctgtct ccacttggtc atgaacactg
       61 aactcagaag acgcaccatg gagtttgtgc tgagtttggt tttccttgtt gctattttaa
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggta aagcctgggg
      181 ggtccctgag actctcttgt gtagcctctg ggttctcctt cagtacctat cctttacact
      241 gggtccgcca ggctcccggg aagggtctgg agtgggtctc agttattagt gaaactggtg
      301 gaaccacata ctacgcagac tctgtgaagg gccgcttcac catctccaga gacaacgcca
      361 agaactcact gtttctgcaa atgaacagcc tgagagccga ggacacggcc gtctattatt
      421 gtactagagt caaatattac tatgatagtg gttattacgt cgggccattt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003679             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15076:19772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003679
VERSION     KCXD01003679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15076:19772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62161.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          121 c          145 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgcag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003680             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19681:18701
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003680
VERSION     KCXD01003680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19681:18701"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62162.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          131 c          138 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 gggtctatca gaagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatctatgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagtgct ccctgaagtt gagcgctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003681             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5812:5198
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003681
VERSION     KCXD01003681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5812:5198"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62163.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          119 c          153 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003682             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4871:16258
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003682
VERSION     KCXD01003682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4871:16258"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..329
     V_segment       8..250
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <242..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62164.1"
                     /translation="CARARYYHDSGYHWYFDIW"
     D_segment       257..276
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..329
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           83 a           94 c           82 g           72 t
ORIGIN      
        1 acatggggtg aagctctcct gcaaggcttc tggatacacc ttcaacatct atgccatcag
       61 ttgggtgcga caggcccctg gacaagggct tcagtggatg ggaggaatca tccctcttgt
      121 tgatctaaca aactacgcac aagaattcca gggcagagtc acgattaccg cggacacgtc
      181 cacaaccact gcctacatgg agctgagcag cctgagatct gaggacacgg ccatatatta
      241 ctgtgcgaga gcgcgatatt accatgatag tggttaccac tggtacttcg atatctgggg
      301 ccctggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01003683             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15363:13537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003683
VERSION     KCXD01003683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15363:13537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..477
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62165.1"
                     /translation="CAIGPSGNWIHWSFDVW"
     D_segment       412..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>481
                     /gene="IGHG"
BASE COUNT          106 a          148 c          134 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcccgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaactg tccatgcact gggtgcgaca
      241 ggcccctgga aaaggacttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgat
      301 gttccagggc agagtcacaa tgaccgagga cacgtctaca gacacagcct acatggagct
      361 gagcagcctg acacctgacg acacggccgt ctattactgt gcgattggcc ctagcggcaa
      421 ctggatccac tggtccttcg atgtctgggg ccctggcacc ccaatcacca tctcctcggc
      481 c
//
LOCUS       KCXD01003684             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21014:13539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003684
VERSION     KCXD01003684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21014:13539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62166.1"
                     /translation="CASPLLPATGNW"
     D_segment       412..419
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          132 c          132 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgatg tctctggtca
      181 ttccatcaat agtggttact cctggggctg gatccgtcag cccccaggga agggactgga
      241 gtggattggg tttatcggtg gtcgtagtgg gtacccctac tacaacccct ccctcaggag
      301 tcgagtcagt atctcaaaag acacgtccaa gaaccagttc tccctggaag tgagttctct
      361 gagcgccgcg gacacggccg tgtattattg tgcgagtcct ctccttccgg caactggaaa
      421 ctggggccag ggagtcctgg tcatcgtctc ctcagcc
//
LOCUS       KCXD01003685             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:26574:9039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003685
VERSION     KCXD01003685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:26574:9039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..456
     V_segment       92..385
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62167.1"
                     /translation="CAREYCTSDSCAGFLDSW"
     D_segment       386..393
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>463
                     /gene="IGHG"
BASE COUNT          103 a          128 c          136 g           96 t
ORIGIN      
        1 acatggggag cccctgggag cacagctcat caccatggac tggacctgga ggctcctctt
       61 tgtggtggca gcagctacag gtgtccagtc ccaggtccat ttggtgcagt ccggggctga
      121 ggtgaagaag cctggggcct cagtgaaggt ttcctgcaag gcttctggat tcaccctcga
      181 caactatgga atcaactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggagt
      241 gatcatcccc cttgtcggta tagtgaacta cgtagagaac ctccagggca gaggcacgat
      301 aaccgcggac acgtcaacaa acacagtcta catggaactg aacagcctga gatctgacga
      361 cacggccatc tattactgtg cgagagaata ctgcacttct gattcttgcg ccggattcct
      421 tgactcctgg ggccagggag tcccggtcac cgtctctcca gcc
//
LOCUS       KCXD01003686             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21002:16238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003686
VERSION     KCXD01003686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21002:16238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62168.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          144 c          137 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccat
      121 tctgaggtcc agctggtgca atctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctttatatgg tgaaatgata
      301 cacacagaac agttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgggcagcct gagatctgag gacacggccg tgtattactg tgcgagtggc
      421 cctagcggca gctggaacga ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003687             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:20973:11026
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003687
VERSION     KCXD01003687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:20973:11026"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62169.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          129 c          138 g          106 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccg tcacctgcgg tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatctatgg gagggatagt agtaccaact acaacccctt tctcaagagt
      301 cgagtcatcc tgtcagtaga cacgtccaag aaccagtgct ccctgaagat gacctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003688             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:25227:13870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003688
VERSION     KCXD01003688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:25227:13870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62170.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          121 a          141 c          129 g           98 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat gcctgcactg ggttcgacag
      241 gcccctggaa aagggcttga gtggatggga agttttaatc ctatatatgg tgaaatttta
      301 caaacagaga agtgccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01003689             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12465:9966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003689
VERSION     KCXD01003689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12465:9966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62171.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       434..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          109 a          122 c          143 g          117 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcccctt cactacctct ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctcg agtggctgac agttatatcg tttgatgaaa
      301 ctaaggaata ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      361 agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacgcggcc gtgtattact
      421 gtgcgagaga ttcttacggc cgaggctttg actcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01003690             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12079:15384
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003690
VERSION     KCXD01003690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12079:15384"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..428
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62172.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       377..382
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..428
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT           91 a           97 c          131 g          111 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttctttgttg ctattttaag
       61 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatttctg gcatgcactg
      181 ggtccgccag gctccaggga aggggctgga gtggctggca gttaaatcgt ttgatggaac
      241 taagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag acaattccaa
      301 gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg tttattactg
      361 tgtgagagac gcctacggga gcggtttgga ttcctggggc caaggggtcg tcgtcaccgt
      421 ctcctcagcc
//
LOCUS       KCXD01003691             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9002:10894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003691
VERSION     KCXD01003691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9002:10894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62173.1"
                     /translation="CANGHWGNGFDYL"
     D_segment       436..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          105 a          118 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cggaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt ggcagttctt tcgtctgatg
      301 gaagtaggaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtctatctt cacatgaaca accttaaatt ggaggacacg gccatgtatt
      421 tctgtgcgaa cgggcactgg gggaacggct ttgactactt gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003692             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:10581:20541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003692
VERSION     KCXD01003692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:10581:20541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62174.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       437..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          108 c          156 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggctggg ttcagccggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagca acggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagtgatat cgtttgatga
      301 aagtaagaaa tactatgcag actctgtgaa ggaccgattc accgtctcca gagacaattc
      361 caagaacatg gtatatcttc aaatgaacaa cttgaaattg gaggacacgg ccgtgtatta
      421 ctgtgtgaga gactcttatg gaagtggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003693             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12847:17357
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003693
VERSION     KCXD01003693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12847:17357"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62175.1"
                     /translation="CTKGRSGGVWPNSFDYW"
     D_segment       426..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          133 c          143 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggct acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 cccaggaaaa gggcttgagt ggatgggaag tgttgatcct gtctatggtg aaataattgt
      301 cgcagagaat ttccaggaca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctgg aatctgagga cacggccatg tattactgta cgaaagggag
      421 gagtggtggt gtctggccga actcctttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003694             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12573:15144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003694
VERSION     KCXD01003694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12573:15144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62176.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          116 a          119 c          156 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcc cttatatcgt
      301 ttgatggaac taagcaatac tacgcagact ctgtgaagga ccgattcacc atttcaagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tgcattactg tgcgagagtt agtggtcata cagagggtac agttgaatac tttgactact
      481 ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01003695             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21931:15737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003695
VERSION     KCXD01003695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21931:15737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    11..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        11..280
     V_segment       11..212
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <205..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62177.1"
                     /translation="CARGTGAILVYFDHW"
     D_segment       217..223
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       235..280
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>282
                     /gene="IGHG"
BASE COUNT           68 a           70 c           83 g           61 t
ORIGIN      
        1 acatggggat actactatat gacctgggtc cgccaggctc cagggaaggg gctggagtgg
       61 atctcaggta ttaacagtga tgggagtagc acatactatg cagactccgt gaaggacaga
      121 ttcaccatct ccagagacaa cgccaagaac acactgtctc ttcaaatgga cagcctgaca
      181 gctgaggaca cggctgtcta ttattgtgcg agggggactg gggcgattct tgtgtacttt
      241 gaccactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003696             303 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21684:10409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003696
VERSION     KCXD01003696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 303)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 303)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21684:10409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..301
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..301
     V_segment       8..236
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>270
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62178.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       242..247
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       253..301
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        302..>303
                     /gene="IGHG"
BASE COUNT           77 a           72 c           81 g           73 t
ORIGIN      
        1 acatggggtg cagcctctgg attcaccttc agtagttata gcatgcactg ggtccgccag
       61 gctccaggga aggggctgga gtgggtggca gttatatcgt acgatgaaac taagaaatac
      121 tacgtagact ctctgaagga ccgattcacc atctccagag acaattccaa gaacatgctt
      181 tatcttcaaa tcaacaacct gaaattggag gacacggccg tttattactg tgcgaggagg
      241 ccctggagtg cagatgcttt tgatttctgg ggccaaggac tcagggtcac cgtctcttca
      301 gcc
//
LOCUS       KCXD01003697             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15649:6956
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003697
VERSION     KCXD01003697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15649:6956"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62179.1"
                     /translation="CAAGHSGSWNYWYFDFW"
     D_segment       426..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          110 a          140 c          143 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctgcag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggcgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtggggg gtgttgatcc tgcatttggt gaaatgatac
      301 acgtagagag gttccagggc agagtcaccc tgaccgagga cacgtctaca gatacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtttttctgt gcagccggac
      421 atagtggcag ctggaactac tggtacttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01003698             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14548:2879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003698
VERSION     KCXD01003698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14548:2879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..488
     V_segment       140..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62180.1"
                     /translation="CARADRGSSIDYW"
     D_segment       439..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>494
                     /gene="IGHG"
BASE COUNT          113 a          114 c          148 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aagactcacc atgaagtttg ggctgagttg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtggg gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagaacc tatggcttac
      241 actgggtccg ccaggcccca gggaaggggc ttgagtgggt ggcggttata tcatatgatg
      301 atgacaagaa atattacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat tctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtttt
      421 attgtgcgag agcggatcgc ggcagttcaa ttgactactg gggccaggga gtcctggtca
      481 ccgtctcccc agcc
//
LOCUS       KCXD01003699             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4963:10560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003699
VERSION     KCXD01003699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4963:10560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62181.1"
                     /translation="CARWEAASFDYW"
     D_segment       404..408
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           84 a          131 c          137 g          106 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgtaa gaacatcaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagc agtggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccgtcag cggtggttat ggctggagct ggatccgcca ggccccaggg aagggactgg
      241 agtggattgg gagtatctat ggtcatagtg gtagcacccg ctacaatccc tccctcaaga
      301 gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaag ctgatctctg
      361 tgaccgccgc ggacacggcc gtgtatttct gtgcgagatg ggaagctgcc tcttttgact
      421 actggggtca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003700             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23582:17788
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003700
VERSION     KCXD01003700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23582:17788"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62182.1"
                     /translation="CARSPSGSWLYWYFDFW"
     D_segment       427..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          149 c          132 g           98 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaagtttc cggatacacc ttcaccgaat tttccatgca ctggctacga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg atcctgcttt tggtgaaatg
      301 atacacgcag agaaattcca gaacagagtc accctgaccg aggacacctc tacagacaca
      361 gcctacatgg agctgactag cctgagatct gaggactcgg ccgtgtatta ctgtgcgcgc
      421 tcacccagcg gcagctggct atactggtac ttcgatttct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01003701             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17123:7038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003701
VERSION     KCXD01003701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17123:7038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..497
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62183.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       424..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..497
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          149 c          139 g          102 t
ORIGIN      
        1 acatggggga catagcaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtacagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgtaag gcttctggat acaccttcaa catctatgcc atcaattggg tgcgacaggc
      241 ccctggacag gggcttgagt ggatgggagg gatcatccct cttgttgata tgacaaacta
      301 cgcacagagg ttccagggca gagtcacgat taccgcggac acgtccacag ccacagcctt
      361 cttggaactg agcagcctga gatctgacga cacggccatt tattactgtg cgagagcccg
      421 ggcctacggt agcggctacc gctcagactg gttcttcgat gtctggggcc ctggcacccc
      481 aatcaccatc tcctcagcc
//
LOCUS       KCXD01003702             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13529:18303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003702
VERSION     KCXD01003702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13529:18303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62184.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       454..466
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          116 a          115 c          153 g          127 t
ORIGIN      
        1 acatggcggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc atttggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtggctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcac tgatatcgta
      301 tgatggaagt aaggaatact atgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt attttcaact gcacaacctg aaattggagg acacggccat
      421 gtattactgt gcgagagtgg ggacatatga tagtggttat tatacctttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003703             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23585:8781
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003703
VERSION     KCXD01003703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23585:8781"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62185.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       405..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          143 c          135 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag ccacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccaaatg cgtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc aacttctact ggaactggat ccgccagacc ccagggaagg ggctggagtg
      241 gattgggtgt atcagtggtg atagtgggag caccgactac aacccctccc tcaagagtcg
      301 agtccacatt tcgacagaca cgtccaagaa acagttctcc ctgaagatga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagacccc cggtggcagc tggaactcct
      421 cttctttgac tattggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003704             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:26670:11397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003704
VERSION     KCXD01003704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:26670:11397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62186.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          117 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggga tggggctgga gtgggtggca gttctatctt
      301 ccgatggaaa taagatatac tacgcagact ctttgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgcgagat gtcaggggaa cggggtttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003705             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16069:8375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003705
VERSION     KCXD01003705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16069:8375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62187.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       441..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          112 c          160 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgttattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcccg
      181 gggggtcact gagactgtcc tgtgcagcct ctggattcac cttcagtagc tctggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtggga ggcacttata tctaatgatg
      301 gaagtaagaa atattacgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctgtatctt caaatgaaca acctgaaatt ggatgacacg gccgtgtatt
      421 actgtgcgcg agttggagag ggtagtggtg gtgcggagga ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003706             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8094:14391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003706
VERSION     KCXD01003706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8094:14391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62188.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       416..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          143 c          126 g          100 t
ORIGIN      
        1 acatggggat caacacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaccacctt caccgaatta tccctgcact gggttcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagttttaat cctatatatg gtgaaatttt
      301 acacacagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgacatctga ggacacggcc gtgtattact gtgcggcagc
      421 tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003707             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:24266:4157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003707
VERSION     KCXD01003707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:24266:4157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..468
     V_segment       114..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62189.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       410..416
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          112 a          115 c          138 g          105 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggact gagtgtccag tgtgaggtag
      121 agctggtgga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
      181 cagcctctgg attcatcttc aatacctatg ccatgcactg ggtccgccag gctccaggga
      241 aggggctgga gtgggtggca gttatttcgc atgatggaaa caagaaatac tacacagact
      301 ctgtgaagga ccgattcacc atctccagag acaattccaa gaacattcaa tatcttcaca
      361 tgaacaacct gaaattggag gatacggcca tatactactg tgcggcctcc tacttggggt
      421 acggatttga gtactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003708             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13663:13672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003708
VERSION     KCXD01003708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13663:13672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62190.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       443..452
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          122 c          154 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtgg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cgacctctgg attcaccttc agtcgctttg
      241 gcatgcactg ggtccgccag gctccagggg aggggctgga gtgggtggca gtcatatcgt
      301 ctgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa cgacatgtta tatcttcaca tgaacgacct gaaattggag gacacggccg
      421 tgtattactg tgcgcgagac gtctacggta gcggacttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003709             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:27331:10595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003709
VERSION     KCXD01003709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:27331:10595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62191.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          113 a          146 c          138 g           95 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgacttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac atacacagcc
      361 tacatggagc tgagcagcct gtcatctgag gacacggccg tgtatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01003710             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20371:6064
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003710
VERSION     KCXD01003710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20371:6064"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62192.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          140 c          150 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctgggac tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgaaatg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gtgaaataat
      301 acacgcagag agcttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgagatctga ggacacggcc gtgtattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccagcct cttctacggt ttggattcct ggggtcaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003711             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10135:20404
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003711
VERSION     KCXD01003711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10135:20404"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..491
     V_segment       146..444
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62193.1"
                     /translation="CTSRSYYW"
     J_segment       453..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          121 c          143 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga cactctcctg tgcagcctct ggattcacct tcagtgacta
      241 tgccatgaac tgggtccgcc aggcttctgg gaaaagactg gagtgggtcg gctatataag
      301 aagcaaatat aataattacg cgacagaata cgccccatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaagg acacggtata tctgcaaatg agcagcctga aaaccgaaga
      421 cacggccgtg tattactgca ccagtcgaag ctactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003712             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13875:5083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003712
VERSION     KCXD01003712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13875:5083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62194.1"
                     /translation="CGRDDSGVIIDYW"
     D_segment       439..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          114 c          153 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtacc tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactacgca gactctgcga aggaccgatt taccatctcc agagacaatc
      361 ccaagaacct gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgattct ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003713             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20459:17658
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003713
VERSION     KCXD01003713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20459:17658"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..316
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..316
     V_segment       8..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62195.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       268..273
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..316
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        317..>322
                     /gene="IGHG"
BASE COUNT           76 a           81 c           94 g           71 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgactc
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gaatgggtgg cggttatatc
      121 caatgatgga agtaagaaat actacgcaga ctctctgaag gaccgattca gcatttccag
      181 ggacaacccc aagaacatac tatatcttca aatgaacaac ctgaaattgg atgacacggc
      241 cgtctattac tgtgcgacag atgcgtttgg tagcgggatt gactactggg gccggggagt
      301 cctggtcacc gtctccgcag cc
//
LOCUS       KCXD01003714             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7048:13643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003714
VERSION     KCXD01003714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7048:13643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..327
     V_segment       8..257
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62196.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       261..268
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           71 a           96 c           87 g           75 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc agcaatagct
       61 actggaactg gatccgccag cccccaggga agggactgga gtggattggg tatatctctg
      121 gtgcttatgg gagcaccagc tacaaccccg ccctcaagag tcgagtcacc atttcaacag
      181 acacgtccaa gaaccagttt tccctgaggc tgagttctgt gaccgccgcg gacaccgccg
      241 tgtattattg tgtgagatat gaggatgaat ccattaacta ccactttgac ttctggggcc
      301 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003715             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16516:10815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003715
VERSION     KCXD01003715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16516:10815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62197.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          115 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttgag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc attaactatg
      241 gcattcactg ggtccgccag gctccagtga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgcacagcct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtccggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003716             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23947:2498
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003716
VERSION     KCXD01003716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23947:2498"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..279
     V_segment       8..204
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62198.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       217..226
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..279
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           67 a           66 c           91 g           57 t
ORIGIN      
        1 acatgggatc catgcactgg gtgcgacagg ccccaggaaa agggcttgag tggatgggaa
       61 gtgttgatcc tgtatatggt gaaataattg tcgcagagaa tttccaggac agagtcacca
      121 tgaccgagga cacgtctaca gacacagcct acatggagct gagcagcctg gaatctgagg
      181 acacggccgt gtattactgt gcgaaaggga ggagtggtgg tgtctggccg agctccttcg
      241 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003717             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21286:16948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003717
VERSION     KCXD01003717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21286:16948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62199.1"
                     /translation="CARWESADFDYW"
     D_segment       400..405
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           94 a          127 c          134 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 gcctccatca gcggtggtta tggctggagc tggatccgtc aggccccaga gaaaggactg
      241 gagtggattg ggaatatcta tggatatagt ggtagcacaa actacaaccc ctccctcagg
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gatgagctct
      361 gtgaccgccg cggactcggc cgtgtattat tgtgcgagat gggagtcagc ggactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003718             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19408:16427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003718
VERSION     KCXD01003718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19408:16427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62200.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       443..448
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          114 c          152 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaaga ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacgtt cagtaactat
      241 ggaatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tacgatgaaa ataagaaata ctacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct ttatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgcgaggag gccctggagt gcagatgctt ttgatttctg gggccaagga
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01003719             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12878:11953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003719
VERSION     KCXD01003719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12878:11953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..493
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62201.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       437..443
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>496
                     /gene="IGHG"
BASE COUNT          114 a          114 c          146 g          122 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccggtgtg aggtgcaact ggtggagtct ggaggaggct tggttcaacc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta attttggcat
      241 acactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tttcgtctga
      301 tggaagtaac aaatactacg ccaactctgt gaagagccga ttcaccatct ccagagacaa
      361 ttccaagagc atactatatc ttcaaatgaa caacttgaaa ttggaggaca cggccgtcta
      421 ttactgtgcg agagatgata ttgggaccgg ttttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcaacc
//
LOCUS       KCXD01003720             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:21243:13501
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003720
VERSION     KCXD01003720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:21243:13501"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..443
     V_segment       102..356
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <350..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62202.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       372..383
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..443
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          102 a          131 c          126 g           86 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcctgggg cctcagtgaa
      121 ggtctcctgt caggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      181 ggcccctggg aaagggcttg agtggatggg agttgttgat cctgtcaatg gtgaagaaat
      241 tcacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      301 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattact gtgcgacagg
      361 gaggatcggt ggcagcggct ggtccaacct cttcaccggt ttggaatcct ggggccaagg
      421 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003721             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12075:10967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003721
VERSION     KCXD01003721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12075:10967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62203.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       409..413
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           91 a          138 c          131 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gcgccatcag cagtggtttc tactggacct ggatccgcca acccccaggg aaggggctgg
      241 agtggattgg gtgtatcggt ggtaatagtg gtaccaccta ctacaacccc tccctcaaga
      301 gtcgagccac catttcaaaa gacacgtcca acaatcaact ctccctgaag gtgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga tgaagacccc tccatttttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003722             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11019:16135
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003722
VERSION     KCXD01003722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11019:16135"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62204.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       408..414
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           85 a          138 c          139 g          105 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagttccca gatgggtcct gtcccaggtg cggctgcagg
      121 agtcgggccc aggacttgtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggggct ggatccgccg gcccccaggg gagggtctgg
      241 agtggattgg gtatatcagt gggagtggtg ggagttccga ctacaagtcc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccactt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagagt ccggggcgta actatccact
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003723             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12004:19041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003723
VERSION     KCXD01003723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12004:19041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62205.1"
                     /translation="CASVRYSGYKYGPFDYW"
     D_segment       422..429
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          119 a          131 c          147 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct ggggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg acacacgttc agcgaactag ccatgcactg ggtgcgacaa
      241 gaccctggaa aagggcttga gtgggtgggc ggtgttgatc caataaatgg tgagatcgtg
      301 tatgcagaga agttccaggg cagaattacc atgaccgaag agacgtccac agacacagtc
      361 tacatggaat tgagcagcct gagatctgag gacacggccg tgcattactg tgcgagtgtc
      421 cgatacagcg gatacaaata cggcccgttt gactactggg gccagggagt cctggtcatc
      481 gtctcctcag cc
//
LOCUS       KCXD01003724             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:10117:6913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003724
VERSION     KCXD01003724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:10117:6913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62206.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          116 a          143 c          131 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccagacttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccga gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gactactggg gccagggagc cctggtcacc gtttcctcag
      481 cc
//
LOCUS       KCXD01003725             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:8528:18541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003725
VERSION     KCXD01003725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:8528:18541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62207.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          121 a          142 c          142 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgata ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggaat tgagcagcct gacatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaatctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003726             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23426:8610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003726
VERSION     KCXD01003726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23426:8610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62208.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       453..460
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          106 a          123 c          158 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggggata gcacctacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagctgacga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatatt tcgacttctg gggccagggc
      481 gcactggtca ccgtctcctc agcc
//
LOCUS       KCXD01003727             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13461:19036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003727
VERSION     KCXD01003727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13461:19036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..491
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62209.1"
                     /translation="CATADYGNSLDFW"
     D_segment       435..446
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          111 a          115 c          151 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccaaagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggtattcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtatgga attctatgga gactctatga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caagtgaaca acctgaaatt ggaggacact gccgtttatt
      421 actgtgcgac agccgactac ggtaacagcc ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01003728             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12706:14932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003728
VERSION     KCXD01003728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12706:14932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..492
     V_segment       141..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62210.1"
                     /translation="CTGGAYANLDYW"
     D_segment       441..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          124 c          154 g          108 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctggactgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaga tggtggagtc tgggggcggc ttggcaaaac
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactactgga
      241 tgaactgggt ccgccagact ccaggaaagg ggctggagtg ggtctcagct attaattatg
      301 atgggggtag cgcatactac gcagactccg tgaagggccg attcaccatt tccagagaca
      361 actcaaagag tacgctctcc ctgcaaatga gcagcctgag agcggaggac acggccgtat
      421 attactgtac gggcggggca tacgctaacc tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003729             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10359:18811
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003729
VERSION     KCXD01003729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10359:18811"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..494
     V_segment       128..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62211.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       427..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..494
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          143 c          139 g           99 t
ORIGIN      
        1 acatggggga gagcatcaca caacagccac atccctcccc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag ctgcaggcgc
      121 ccgctctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaaggtctcc tgcgaggttt ccggatacac cttcaccgaa ctgtccatcc actgggtgcg
      241 acaggcccct ggaaaaggcc ttgagtggat gggaagtgtt gatcctgaat atggtgaaat
      301 gataaacgca gaaaacttcc agggcagagt caccttgacc gaggacacgt ctacaggaac
      361 ggcctacatg gagctgatca gcctgagatc tgaagacacg gccgtgtatt actgtgcgac
      421 atcacccagc ggcaattggc ttttttggta cttcgatttt tggggccctg gcaccccaat
      481 caccatctcc tcagcc
//
LOCUS       KCXD01003730             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18832:4958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003730
VERSION     KCXD01003730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18832:4958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..520
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62212.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       451..462
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..520
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          119 a          126 c          151 g          126 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattt ccagctgtct ccagttggcg
       61 atcagcactg aacacaggag actcgccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgacttt
      241 gccatgagct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      301 accaaatata acaattacgc ggcagaatac gccgcatcgg tgaaaggcag gttcaccatc
      361 tccagagatg attcaaagaa cacgatatat ctgcaaatga gtagcctgaa aaccgaggac
      421 acggccgtgt atttctgcac cacatggaga tattactata gtactggtta ccccaccttt
      481 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003731             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:16042:3572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003731
VERSION     KCXD01003731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:16042:3572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62213.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          111 c          157 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagt agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgaa tcgcatgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgagca acctgaaatt ggtggatacg gccatgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003732             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22489:9854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003732
VERSION     KCXD01003732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22489:9854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..471
     V_segment       87..380
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62214.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       415..420
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           92 a          145 c          128 g          108 t
ORIGIN      
        1 acatggggac ggacatcctg tgcaagaaca tgaagcacct gtggttcttc ctcctcctgg
       61 tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc ccacgactgg
      121 tgaagccttc ggagaccctg tccctcacct gcgctgtctc tggtggctcc ttcagcggct
      181 actactggag ctggatccgc cagcccccag ggaagggact ggagtggatt gggcatatca
      241 gtgggagtag tgggagcacc gactacaacc cctccctcaa aagtcgagtc accatttcaa
      301 cagacacgtc caagagccac ttctccctga aactgagctc tgtgaccgcc gcggacacgg
      361 ccgtgtatta ctgtgcgaga gagttttccc cctacgacta ttcttggagt gatttttact
      421 cttactactt tgactacttg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003733             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21017:9616
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003733
VERSION     KCXD01003733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21017:9616"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    147..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        147..437
     V_segment       147..376
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62215.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       386..393
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT          101 a           97 c          132 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac agctggtgga ttcaccttca gtagttttgg
      181 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgtc
      241 tgatggaagt agcatatact atgcagcctc tgtgaaggac cgattcacca tctccagaga
      301 caattccaag aacatgctat atcttcaaat gaacaacctg aaatttgagg acacggccgt
      361 gtattactgt gcgagagatg tgtacggtag tgggttagac tactggggcc tgggagtcct
      421 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003734             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:10277:11306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003734
VERSION     KCXD01003734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:10277:11306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62216.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..457
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          112 a          122 c          151 g          124 t
ORIGIN      
        1 acatggggtc taggagagga gcccagccct gggattccca ggtgttttca tttgtgatca
       61 gcactgaaca cagaagactc atcatggagt ttggcctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagggt gaggtacaac tggtggaatc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccctcagt aactactgga
      241 tgtactgggt tcgccaggca ccagggaagg ggctggagtg gatctcagct attaacagtg
      301 ttggtgatac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaagaa cacactgtat cttcaaatgg acagcctgag agctgaggac acggctatct
      421 attactgtgc gagagttccg ggcctagtgg tatttaccgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003735             378 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13118:17714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003735
VERSION     KCXD01003735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 378)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 378)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13118:17714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    22..376
                     /note="immunoglobulin heavy chain variable region"
     V_region        22..376
     V_segment       22..315
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <307..>345
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62217.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       326..334
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       337..376
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        377..>378
                     /gene="IGHG"
BASE COUNT           82 a           94 c          115 g           87 t
ORIGIN      
        1 acatggggag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
       61 ccgggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tacttttggc
      121 atccactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtct
      181 gatggaaata acctatacta cgcagactct ctgaaggacc gattcaccat ctccagagac
      241 aattccaaga acatggtgta tcttcaaatg aacaacctga aattggagga cacggccgtc
      301 tattactgtg cgagagattc atatggcagc ggctccgact actggggcca gggagtcctg
      361 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003736             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17327:10462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003736
VERSION     KCXD01003736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17327:10462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62218.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       451..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          119 c          150 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggcgc agctggtgga atctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cggcctctga attcaccttc agcagctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtatca ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 atgccaagaa ctccttgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtgc aagggggata gataactacc actatagtga tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003737             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18757:14320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003737
VERSION     KCXD01003737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18757:14320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62219.1"
                     /translation="CARVGEDSGGAEDLDFW"
     D_segment       447..454
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          116 c          157 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaggacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgagatac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga atgggtggca cttatatcgt
      301 atgatggaga taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgtacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagtt ggagaggata gtggtggtgc ggaggacctt gacttctggg
      481 gccaaggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003738             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:17979:10981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003738
VERSION     KCXD01003738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:17979:10981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62220.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          116 a          112 c          155 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaac taagaagtac tacggagact ctgtgaaaga ccgattcacc atttccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tatattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01003739             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6493:6569
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003739
VERSION     KCXD01003739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6493:6569"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62221.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          115 c          151 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003740             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10926:3785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003740
VERSION     KCXD01003740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10926:3785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62222.1"
                     /translation="CAREYFTSDACAGFFDYW"
     D_segment       420..426
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          118 a          137 c          138 g          104 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc
      121 agtcccaggt ccacttggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg caaggcttct ggattcaccc tcgacaacta tggaatcaac tgggtgcgac
      241 aggcccctgg acaagggctg gagtggatgg gagtgatcat cccccttgtc ggtatagtga
      301 actacgtaga gaacctccag ggcagagcca cgataaccgc ggacacgtca acaaacacag
      361 tctacatgga attgaacagc ctgagatctg acgacacggc catctattat tgtgcgagag
      421 aatactttac ttctgatgct tgcgccggat tctttgacta ctggggccag ggagtcccgg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01003741             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18551:10206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003741
VERSION     KCXD01003741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18551:10206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..493
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62223.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          109 a          117 c          157 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagcagtgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctggctg ttgaatcgca
      301 cgatggaaat aagaaatact atgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat accttcaaat gaacaacctg aaattggtgg atacggccat
      421 gtactattgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tccccagcc
//
LOCUS       KCXD01003742             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14354:3434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003742
VERSION     KCXD01003742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14354:3434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62224.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       406..412
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          135 c          135 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacagaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg gctggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag agagtactat tggagctgga tccgccaggc cccagggaag ggactggagt
      241 ggattggcta catctatggt aacattggga gcaccagcta taacccgtcc ctccagagtc
      301 gagtcaccgt ttcaatagac acgtccaaga atcacttctc cctgaagttg acgtctgtga
      361 ccgccgcgga cacggccgta tatcactgtg cgagacatct ctattcctgg aaagggaagt
      421 ggatcgatgt ctggggcccg ggagtcctga tcaccgtctc ctcagcc
//
LOCUS       KCXD01003743             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:9536:20477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003743
VERSION     KCXD01003743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:9536:20477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    54..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        54..426
     V_segment       54..346
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <345..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62225.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       361..374
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       379..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           94 a          104 c          129 g          101 t
ORIGIN      
        1 atggggtact gagctgggtt ttccttgttg ctatattaaa aggtgtccag tgtgaggttc
       61 agctggtgga gtctggggga ggcttggtcc agcctggcgg gtccctgaga ctctcctgtg
      121 cagcctctgg attcagcttc agtgactatg gcatgagctg ggtccgccag gcctctggga
      181 aaggactgga gtgggttggc tacattagaa gcacacatag gaattacgcg acggaatacg
      241 ccgcatcggt gaaaggcaga tgcaccatct ccagagatga ctcaaagaac acactatatc
      301 tgcaaatgag cagcctgaga accgaggaca cggccgtgta ttactgcacc accctctatg
      361 gtggtagtta ttacgtggac tactttgact cctggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01003744             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:28327:11634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003744
VERSION     KCXD01003744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:28327:11634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62226.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          117 c          151 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgtggcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcggc
      181 ctggggggtc cctgagactc tcctgtgcag tctctggatt caccttcagt aattttggca
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt atatcgtctg
      301 atgaaagtaa gaaatactat gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa cttggaggac acggccgtct
      421 attactgtgc gagggacgca tttggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003745             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5411:7925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003745
VERSION     KCXD01003745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5411:7925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62227.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       404..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          142 c          127 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctgctga
      181 ctccatcacc agtagcttct ggaactggat ccgccagccc ccagggaggg ggctggagtg
      241 gattggctat atctctggtt ctactgggag ttccagctac aacccctccc tcaagagtcg
      301 agtctccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gacgatgatt acggttctta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003746             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16198:8972
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003746
VERSION     KCXD01003746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16198:8972"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62228.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       431..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          135 c          149 g          101 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctatgtca tcaattgggt gcgacaggcc
      241 cctggacaag ggctagagtg gatgggaggg atcatccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt tttgcggaca cgtccacaag cacagcctac
      361 atggaattga gaagcctgag atctgaggac acggccgtgt attactgtgc gagaggcccc
      421 cctactgaag ggggtgatta ttctgggggg gctttgagcc gatggggcca gggagtccag
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003747             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17923:8453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003747
VERSION     KCXD01003747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17923:8453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62229.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          112 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg tagcctctgg attcagcttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ttgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatgctg tattttcaat tgaacaacct gaaattggaa gacacggccg
      421 tgtatttctg tgcgagagat gtctatggca ggggacttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003748             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11727:16907
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003748
VERSION     KCXD01003748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11727:16907"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62230.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       445..451
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          112 a          118 c          152 g          120 t
ORIGIN      
        1 acatgggggg agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tgctatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt
      181 tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtacctc
      241 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtggctga cagttatatc
      301 gtatgatgaa actaagaaat attacgcaga ctctgtgaag gaccgattca ccatctccag
      361 agacaattcc aagaacatgg tatatcttca aatgaacaac ctgaaattgg aggacgcggc
      421 cgtgtattac tgtgcgagag attcttacgg tcgaggcttt gactcctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003749             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14952:17180
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003749
VERSION     KCXD01003749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14952:17180"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62231.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          152 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgttattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggcttcac cttcaattcc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcggttata tcgcatgatg
      301 aaactaagaa atactacgca gactctgtga aagaccgatt cagcatctcc agagacaatt
      361 ccaagaacat ggtctatctt caaatgaaca acctgagatt ggaggacacg gccgtctatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003750             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8294:9801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003750
VERSION     KCXD01003750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8294:9801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    150..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        150..513
     V_segment       150..441
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <435..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62232.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       458..468
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT           99 a          156 c          137 g          123 t
ORIGIN      
        1 acatggggtc tccctcacca cccagctggg gatctcagtg cttcattttc tgtccttcat
       61 ttctcagtgc ttcatttctg tcctccacca cgatggggtc aactgccatc ctcgccctcc
      121 tcctggctgt tctccaagga gtctgtgccg aggtgcagct ggtgcagtct ggagcagagg
      181 tgaaaaggcc cggggaatct ctgaggatct cctgtaagac ttctggatac agttttacca
      241 attactggat cagttgggtg cgccagatgc ccgggaaagg cctggagtgg atgggaatga
      301 tctatcctag tgattctgat cccagataca gcccgtcctt ccaaggccag gtcaccatct
      361 cagccgacag gtccatcagc accgcctacc tggagtgggg cagcctgaag gcctcggaca
      421 ccgccacgta ttactgtgcg agagctggac gctacaccta cagttacccc tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003751             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22102:15455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003751
VERSION     KCXD01003751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22102:15455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62233.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       440..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          116 a          121 c          160 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggtct gacctgggtt ttccttgttg
      121 gtattttgaa aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggctc
      181 agccgggggg gtccctgaga ctctcctgtg cagcgtctgg gttcaccttc agtagctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggct gccatatcat
      301 ttgatggaag taagaaaaac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa caacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatactactg ttcgagggag tggatacagt gggcacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003752             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:25778:7210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003752
VERSION     KCXD01003752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:25778:7210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62234.1"
                     /translation="CARDGPDGVAVTLFSLDVW"
     D_segment       457..464
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..516
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          107 a          124 c          156 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttc
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca attatatcgt
      301 atgatggaac taagaaatac ctcgcagatt ctgtgaaaga ccgattcacc gtctctagag
      361 acaattccca gaacatgcta tttcttcacc tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgcgagat gggcctgacg gtgtcgcggt aactctgttt tcattggatg
      481 tctggggccg gggagttctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003753             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6660:18994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003753
VERSION     KCXD01003753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6660:18994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62235.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       265..270
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..320
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           75 a           75 c           97 g           75 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgtagcctct ggattcacct tcagtagtag
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtggctgg ctgttgaatc
      121 gcatgatgga aataagaaat actatgcaga ctccgtgaag gaccgattca ccatctccag
      181 agacaattcc aagaacatgg tatatcttca aatgaacaac ctgaaattgg tggatacggc
      241 catgtattac tgtgtgagag atgcctacgg gggcggtttg gattcctggg gccaaggggt
      301 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003754             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23934:8928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003754
VERSION     KCXD01003754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23934:8928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62236.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       417..426
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          137 c          144 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggag gtgttgatcc tctatatggt gaaaaaagac
      301 acgcagagaa gttccagggc agagtctcca tgaccgagga cacgtctaca aacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtactattgt gcgagaggat
      421 attgtagcgg tagtcactgc tcgtccggat ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003755             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16580:4054
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003755
VERSION     KCXD01003755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16580:4054"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62237.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       297..302
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           86 a           82 c          102 g           80 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agcacctttg gcatacactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttatatcat atgatgaaac taagaaatac tacacagact
      181 ctgtgaggga ccgattcacc atctccagag acaattccaa aaacatggta tattttcaaa
      241 tgaacaacct gaaattggag gacacggcca tatattactg tgcgagagat gtcaggggaa
      301 cggggtttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003756             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23059:4271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003756
VERSION     KCXD01003756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23059:4271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62238.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcggggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003757             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10526:20298
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003757
VERSION     KCXD01003757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10526:20298"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62239.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          111 c          157 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaaataagaa atactacgaa gactctctga aggcccgatt caccgtctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatggaca acctgaaatt ggaagacacg gccgtgtatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003758             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14937:5572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003758
VERSION     KCXD01003758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14937:5572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62240.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       415..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          110 a          143 c          137 g           91 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc tttctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccct caccgaagtg tccactcact gggtgcgaca
      241 ggcccccgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtccaca gacacagcct acatggaatt
      361 gagcagccta agatctgagg acacggccgt gtattactgt gcgattggac ctaccggcag
      421 gtggaacggc tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01003759             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6844:9077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003759
VERSION     KCXD01003759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6844:9077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..459
     V_segment       106..396
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62241.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       403..415
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           88 a          137 c          132 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtccgagctg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc tgtcacctgc gctgtctctg
      181 gtgactcaat cagcagttac ttctggaact ggatccgcca ggccccaggg aagggactgg
      241 agtggattgg gtttctctat ggtagtgata gtacctccca ctacaatccc tccctcaaga
      301 gtcgagtcac cctgtctgtg gacacgtcca acaaccaggt ctccctgatg ctgaactctg
      361 tgaccgccgc ggacacggcc gtctattact gtgcgaccgg gaagcggcag ctggatcttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003760             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17323:7098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003760
VERSION     KCXD01003760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17323:7098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62242.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          115 c          151 g          117 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tgttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003761             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11248:17595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003761
VERSION     KCXD01003761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11248:17595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62243.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          118 c          150 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagtctctgg attcaccttc aatacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 gtgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tttattactg tacgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003762             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17553:9584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003762
VERSION     KCXD01003762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17553:9584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62244.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       422..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          142 c          142 g          104 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tccaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa atggcttgag tggatgggag gtgttgctcc tctatatggt gaaatgatgc
      301 tcgcagacaa cttccagggc agagtcacct tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgacg acacggccgt gtattactgt gcgcgtgggc
      421 ctattacaat ttttggcgta cttattacgg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003763             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15284:19898
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003763
VERSION     KCXD01003763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15284:19898"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62245.1"
                     /translation="CVRERFGGIGVIIFNWIDVW"
     D_segment       464..470
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          110 a          122 c          160 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcctga caaagcctgg
      181 ggggtccctg agactctcct gtgcagcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgaatcg gtcatgatgg
      301 tggtttcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagagtgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gacgacacag ccgtatatta
      421 ctgtgtgaga gagcggtttg ggggaattgg ggtaataatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01003764             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10575:20380
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003764
VERSION     KCXD01003764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10575:20380"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62246.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          114 c          151 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag cagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatga
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgaa
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat ttcttcaaat ggacaacctg aaattggagg acacggccgt
      421 ctattattgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003765             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12897:12526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003765
VERSION     KCXD01003765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12897:12526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62247.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          108 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaaa taagaaatat tacgcagact ctgtgaagga ccgattcacc atgtccagag
      361 acaattccag gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttatttctg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003766             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5625:15575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003766
VERSION     KCXD01003766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5625:15575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62248.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       430..439
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          116 a          136 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaaaaccttc actgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ttgcatatga tgaaataatg
      301 gacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgca tactgaatac ttcgagttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01003767             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22402:14631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003767
VERSION     KCXD01003767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22402:14631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..445
     V_segment       91..384
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62249.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       395..403
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..445
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          100 a          102 c          132 g          113 t
ORIGIN      
        1 acatgggtca gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc
       61 cttgttgcga ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc
      121 ttggttcagc cggaggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt
      181 ttctatggct tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt
      241 atttcgaatg atgaaaataa caaatactac gcagactctg tgaaggaccg attcaccatt
      301 tctagagaca attccatgaa catgctattt cttcaaatga acaacctgaa cttggacgac
      361 acggccgtct attactgtgt gagagatgat ttaggcagcg gcttagggtc ctggggccag
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003768             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5346:13673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003768
VERSION     KCXD01003768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5346:13673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..392
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62250.1"
                     /translation="CAKKYSGSYFYGHYDYW"
     D_segment       398..413
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           99 a          134 c          132 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagt gattactggt ggaactggat ccgccagcca ccagggaagg gactggagtg
      241 gattgcggag atcaatgttg atagtggtac cacctactac aacccctccc ccaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgaaggtga cttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gaaaaagtat agtggcagtt atttctacgg
      421 acactatgac tactggggcc agggagtctt ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003769             442 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14769:6988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003769
VERSION     KCXD01003769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14769:6988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..440
     V_segment       74..359
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <356..>409
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62251.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       375..382
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>442
                     /gene="IGHG"
BASE COUNT           99 a          104 c          124 g          115 t
ORIGIN      
        1 acatggggga ctcaccatgg agtttatgct gaactgggtt ttccttgttt ctatattaaa
       61 aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac agcctggggc
      121 gtccctgaag ctctcctgtg cagcctctga gttcaccttc agtgactatg acatgcactg
      181 ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca ttggcggtga
      241 cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca acgccaagaa
      301 ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt attattgtgt
      361 gagggggatg gataactacc acttcagtaa tacggacttt gactactggg gccagggagt
      421 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003770             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9347:16643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003770
VERSION     KCXD01003770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9347:16643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62252.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          134 c          130 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcgg tgtctctggt
      181 gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact gctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003771             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:7818:19923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003771
VERSION     KCXD01003771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:7818:19923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62253.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       442..453
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          105 a          131 c          157 g          114 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggggg cggcttggca
      181 aagcctgggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 gctatacact gggtccgcca ggctcccggg aaggggctgg agtgggtctc agccattagt
      301 agtggtggta gcacatacta cgcagactcc atgaagggcc gagccaccat ctccagagac
      361 aactcaaaga acacggtctc cctgcaagtg aacagcctga cttctgagga cacggccgtg
      421 ttttactgtg cgagagggga gacagcttca gtttactacg ctttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003772             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:23379:7990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003772
VERSION     KCXD01003772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:23379:7990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..478
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62254.1"
                     /translation="CARGLPTVFGVVITDVW"
     D_segment       426..437
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..478
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           96 a          138 c          139 g          107 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagac gggtcctgtc ccaggtgcag
      121 ctgcaggagt cgggcccagg actggtgaag ccctcggaga ccctgtccct cacctgcact
      181 gtctctggtg actccttcag cggttactac tggagctgga tccgccagcc cccagggaag
      241 gggctggagt ggattgggca tatcagtgtt agtcttggga agaccgacta caacccgtcc
      301 ctcaagagtc gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaaggtg
      361 aactctgtga ccgccgcgga cacggccgta tattactgtg cgagaggact tcctacagtt
      421 tttggagtgg ttattacgga tgtctggggc ccgggagtcc tggtcatcgt ctcctcagcc
//
LOCUS       KCXD01003773             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21893:12233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003773
VERSION     KCXD01003773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21893:12233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62255.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       428..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          116 a          135 c          145 g           97 t
ORIGIN      
        1 acatggggga cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa aaaccttcac tgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatctt gcatatgatg aaataatgga
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cggcgggcct
      421 tgggggatat ttactgcata ctgaatactt cgagttctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01003774             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19839:15975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003774
VERSION     KCXD01003774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19839:15975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62256.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       441..445
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          137 c          142 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcag cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa ggacttgagt ggatgggagg tgttgatact gtatctgatg gagtgatata
      301 cgcagagaac ctccagggca gagtcgccat gaccgaggac acgtctacag acacagccta
      361 catggaattg agcagcctga gatctgagga cacggccgtt tattactgtg cgagaggttt
      421 atcaccagac gtcttcggtt tcctcgggct tggctactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01003775             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23383:21808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003775
VERSION     KCXD01003775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23383:21808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62257.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       442..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          112 c          147 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctgtttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gagacttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaacta tggcatacac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtctgatgca
      301 agtaagacat actacgcaaa ctctgtgaag gaccgattca ccatattaag agacaattcc
      361 aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtctattac
      421 tgtgcgagag acgatatggg aagtggcttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003776             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22801:12668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003776
VERSION     KCXD01003776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22801:12668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..293
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..293
     V_segment       9..218
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <212..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62258.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       232..242
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       244..293
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        294..>295
                     /gene="IGHG"
BASE COUNT           67 a           85 c           81 g           62 t
ORIGIN      
        1 acatgggatt tccggataca ccttcaccga attatccata cactgggtgc ggcaggcccc
       61 tggaaaaggg cttgagtgga tgggaagtgt tgatcctctg tatggtgaaa tgaagttcca
      121 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacttgg aactgagcgg
      181 cctgacttct gaggacacgg ccgtgtatta ctgtgcgact ggccctaccg gcacctggaa
      241 cgcctggtac ctcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01003777             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21136:7837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003777
VERSION     KCXD01003777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21136:7837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..264
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <256..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62259.1"
                     /translation="CARMWYWPTPDVW"
     D_segment       270..276
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       285..325
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           60 a           95 c           98 g           74 t
ORIGIN      
        1 acatgggctt cggagaccct gtccctcacc tgcgttgtct ctggtggctc catcagcggt
       61 ggttatggct ggaactggat ccgccaggcc ccagggaagg gactggagtg gattgggagt
      121 ctctttggct gtagtggaag aacctactac aatccgtccc tcaagagtcg agtcgctatt
      181 tcaaaagaca cgtccaagaa ccagttctcc ctgatcctga ggtctgtgac cgccgcggac
      241 acggccgtgt attactgtgc gagaatgtgg tactggccga cccccgatgt ctggggcccg
      301 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003778             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13997:8519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003778
VERSION     KCXD01003778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13997:8519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..436
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <435..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62260.1"
                     /translation="CTSHYSGSYYLDYFDSW"
     D_segment       445..465
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          115 a          120 c          152 g          131 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattc cagctgtctc cacttggtga
       61 tcagcactga acacaggaga ctcgccatgg agtttgtact gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtcc
      181 agcctggcgg gtccctgaga ctctcctgtg ctgcctctgg atttagtttc ggagactttg
      241 ccatgagttg ggtccgccag gcttctggga aaggactgga gtgggttggc tatattagaa
      301 gcgtacatag gaattacgcg acagaatacg ccgcgtcggt aaaaggcaga tttaccatct
      361 ccagagatga ttcaaagaac acgctatatt tacaaatgag cagcctgaaa accgaggaca
      421 cggccgtcta tttctgcacc agccactata gtggtagtta ttacttagac tactttgact
      481 cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003779             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19103:18108
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003779
VERSION     KCXD01003779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19103:18108"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62261.1"
                     /translation="CARRPLPYEDDYSYYLGIFDYW"
     D_segment       413..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          101 a          134 c          140 g          115 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggtgatt atggctggaa ctggatccgc caggccccag ggaagggact
      241 ggagtggatt gggagtattt atggtagtag tggtaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga ggctgagctc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ttgtgcgaga agaccgcttc cctacgagga
      421 tgattacagt tattatttgg ggatctttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003780             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21088:5175
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003780
VERSION     KCXD01003780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21088:5175"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..485
     V_segment       113..406
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62262.1"
                     /translation="CAQGGWWGDYPPSDWLDVW"
     D_segment       416..427
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           95 a          141 c          144 g          107 t
ORIGIN      
        1 acatggggac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca ccacgatggg
       61 gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg ccgaggtgca
      121 gctggtgcag tctggagcag aagtgaaaag gcccggggag tctctgaaga tctcctgtaa
      181 gacttctgga gacacctcta cctactattg gatcagctgg gtgcgccaga tgcccgggaa
      241 aggcctggag tggatggggg cgattgatcc tggtgatttt gataccaaat atagtccgtc
      301 cttccaaggc caggtcacca tctcagccga caagtccatc agcaccgcct acctgcagtg
      361 gagcaggctg aaggcctcgg acaccgccac gtattactgt gcgcaagggg ggtggtgggg
      421 tgattatcca ccctcagact ggctcgatgt ctggggcccg ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003781             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:17605:19600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003781
VERSION     KCXD01003781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:17605:19600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62263.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       437..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          108 a          129 c          148 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctggcttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagg tggaggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatgcta
      241 tgcattgggt ccgccaggct ccagggaagg ggctgaaatg ggtctcatct attagtagtg
      301 gtggtctcac atactacgca gactccgtga agggccgatt tgccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgagcgc tgaggacacg gccgtatatt
      421 actgtgcgaa aggaggtagc agctctttct attggtactt cgatatctgg ggccctggca
      481 ccccagtgac catctcctca gcc
//
LOCUS       KCXD01003782             337 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16033:6307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003782
VERSION     KCXD01003782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16033:6307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..333
     V_segment       5..256
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>304
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62264.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       279..286
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       288..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>337
                     /gene="IGHG"
BASE COUNT           70 a           92 c           99 g           76 t
ORIGIN      
        1 atgggggggg tccctgagac tctcctgtgc agcctctgga ttcacctttg gtgattatgg
       61 catgcactgg gtccgccagg ctccgggaaa gggactggag tggatctcat ccattaggaa
      121 cactggtaaa atcgtatact acgctgactc cgtgaagggc cgattcacca tctccagaga
      181 caacgccaag aactcgctgt ctctgcgaat gagcagcctg agagccgagg acacggccgt
      241 gtattactgt actagaattg gcgtcggatc tctggcaacg gctggtgact attttgacca
      301 ctggggccag ggagtcctgg tcaccgtctc ctccgcc
//
LOCUS       KCXD01003783             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9792:8719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003783
VERSION     KCXD01003783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9792:8719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62265.1"
                     /translation="CATGFGGSWTRFDYW"
     D_segment       411..416
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           90 a          135 c          135 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gtagtaacta ctggagttgg atccgccagg ccccagggaa gggactggaa
      241 tggattggat atatctttgg tagtggcagt gacaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaac aaccagctct ccctggagct gagctctgtg
      361 accgccgcgg acacggccct gtattactgt gcgaccgggt ttggtggcag ttggaccaga
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003784             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8608:7637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003784
VERSION     KCXD01003784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8608:7637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62266.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       421..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          145 c          139 g          104 t
ORIGIN      
        1 acatggggtt cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag ctttccggat ccaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaag gggcttgaat ggatgggagg tgttgctcct ctttatggtg aaatgatgca
      301 cgcagacaac ttccagggca gagtcacctt gaccgaggac ccgtctacag acacagccta
      361 catggagctg agcagcctga catctgacga cacggccgtg tattactgtg cgcgtgggcc
      421 tattacaatt tttggcgtac ttattacggg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01003785             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24168:14820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003785
VERSION     KCXD01003785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24168:14820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62267.1"
                     /translation="CARDSSWYNWNQDFDYW"
     D_segment       408..421
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          102 a          137 c          132 g          101 t
ORIGIN      
        1 acatggggaa tgttctctga gactcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg acccagctgc agcttcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcaaatgcg ctgtctctgg
      181 tggctccatc accggtaact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtagcactg atagtggtgg gagtactgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat agtagttggt ataactggaa
      421 ccaagacttt gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003786             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20354:15654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003786
VERSION     KCXD01003786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20354:15654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62268.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          145 c          136 g           89 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaactgag
      361 cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggcccta ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01003787             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14160:17719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003787
VERSION     KCXD01003787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14160:17719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62269.1"
                     /translation="CARWGDSQSIYYFDFW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           93 a          137 c          132 g          109 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacatgcgc tgtctctggt
      181 gactctatta ccagtagtag ctggtggaac tggatccgcc agcccccagg gaaagggctg
      241 gaatggattg gttatatcag tggtactagt gggagcaccg actatcaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccagt ttaccctgac gttgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagat ggggcgactc ccagtccatt
      421 tactactttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003788             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9679:14225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003788
VERSION     KCXD01003788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9679:14225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62270.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          143 c          135 g           91 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aggccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga tacagcttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaat
      301 tccagggcag agtcaccatg accgaggaca cgtctgcaga cacagcctac atggaactga
      361 gtagcctgac atctgaggac acggccgtgt attactgtgc gactggccct agcggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003789             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20660:11560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003789
VERSION     KCXD01003789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20660:11560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62271.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           92 a          135 c          134 g          100 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctggg caagaacatg aagcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat caacagtggt tatggctgga actgggtccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtctc tatgatagta gtgggaacac gtactacaac ccctccctca
      301 agagtcgcgt caccatttca aaagacacgt ccaaaaacca gttctccctg aacctgaggt
      361 ctatgaccgc cgcggacacg gccgtgtatt actgtgcgag atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003790             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:19311:17884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003790
VERSION     KCXD01003790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:19311:17884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62272.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          106 a          140 c          154 g          104 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggtgttgatc ctgcaaatgg tgaggtaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacggcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 cggttcggta gcagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003791             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7464:5410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003791
VERSION     KCXD01003791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7464:5410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62273.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          112 a          115 c          156 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaca ctctcctgtg tagcctctgg attcaccttc agtagctatg
      241 gcatgggctg ggtccgccag gctccaggga aggggctgga gtgggtggga attgtttcgt
      301 ttgatggaac taagagatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaatatccta tatcttcaaa tgaacaacct gaaattcgaa gacacggccg
      421 tgtattatag tacgagagta gactgtagtg gtggtgtctg ctactttgac cactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003792             420 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15316:6493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003792
VERSION     KCXD01003792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 420)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 420)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15316:6493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    55..418
                     /note="immunoglobulin heavy chain variable region"
     V_region        55..418
     V_segment       55..347
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <340..>387
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62274.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       354..362
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       374..418
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        419..>420
                     /gene="IGHG"
BASE COUNT           87 a           97 c          132 g          104 t
ORIGIN      
        1 acatgggggc tgagctgggt tttccttgtt gctattttaa aaggtgtcca gtgtgaggtg
       61 cagttggtgg agtctggggg aggcttggtc cagcctggag ggtctctgag actctcctgt
      121 gtaggctctg gattcagctt cagaagttac gaaatgagtt gggtccgcca ggctccggga
      181 aaggggctgg agtgggtctc atatattagt cacactggtg aaaccatata ccacgctgac
      241 tccgtgaagg gccgattcac catctccaga gacaacgcca agaattcgct gtctctgcaa
      301 atgagcagcc tgagagccga ggacacggcc gtgtattact gtactagaaa ccggaatact
      361 gtcatgattg ggtggttcga tgtctggggc ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003793             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16189:10489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003793
VERSION     KCXD01003793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16189:10489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62275.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       435..446
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          119 c          150 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccattgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcactaac tatggcatgc
      241 actgggtccg ccaggctcca gggaagggtc tggagtgggt ggcagttatg tcgcatgatg
      301 gaactaagaa attctacgca gactctgtga aggaccgatt caccatctcc agggacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgagact ggaggacgcg gccgtctatt
      421 actgtgcgag aggagactac ggtaacagcc ttgactactg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003794             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13165:6450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003794
VERSION     KCXD01003794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13165:6450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62276.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          146 c          141 g           99 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgatgaagc ctggggcccc agtgaagctc
      181 tcctgcaagg cttctggata caccctcagc atctctgcca tcagttgggt acgacaggcc
      241 cctggacaag ggcttgagtg gatgggagag atcttccctc ttgttggtgt gacaaaatac
      301 gcacagaact tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctgc gcggcctgag atctgaggac acggccgtat attactgtgc gagaagaggt
      421 ggccacggta ccaccaccac gttgtacttc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003795             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17296:15111
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003795
VERSION     KCXD01003795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17296:15111"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62277.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          138 c          135 g           95 t
ORIGIN      
        1 acatggggga cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003796             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22211:6906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003796
VERSION     KCXD01003796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22211:6906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    16..291
                     /note="immunoglobulin heavy chain variable region"
     V_region        16..291
     V_segment       16..217
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <209..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62278.1"
                     /translation="CARTSYGGSYYFFYFDYW"
     D_segment       228..242
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       247..291
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        292..>295
                     /gene="IGHG"
BASE COUNT           78 a           71 c           75 g           71 t
ORIGIN      
        1 acatggggac tatgccatga gctgggtccg ccagacttct gggaaaggac tggagtgggt
       61 tggctatatt agaagcaaat ctaataatta cgcgacagaa tacgccgcat cggtgaaagg
      121 caggttcacc atctccagag atgattcaaa gaacacgcta tatctacaaa tgaccagcct
      181 gaaaaccgag gacacggccg tgtattactg tgctagaact tcctatggtg gtagttatta
      241 cttcttctac tttgactact ggggccaggg agtcctggtc accgtctcct ccgcc
//
LOCUS       KCXD01003797             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16817:7128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003797
VERSION     KCXD01003797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16817:7128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..456
     V_segment       87..378
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62279.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       397..406
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           91 a          141 c          130 g           96 t
ORIGIN      
        1 acatggggac ggacatcctg tgcaagaaca tgaagcacct gtggctcttc ctcctgctgg
       61 tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc ccaggactgg
      121 tgaagccctc agagaccctg tccctcacct gcgctgtctc tggtgcctcc atcggtagtt
      181 actggtggac ctggatccgc cagcccccag ggaagggact ggagtggatt ggggagatca
      241 atggaaatag tggtagtacc tactatagcc cctccctcaa gagtcgagtc accatttcaa
      301 aagacgcgtc caagaaccac ctctccctga agctgaactc tgtgaccacc gcggacacgg
      361 ccgtgtattt ctgtgcgaac gtcttaggcc cctggggcag ctggtcacac tactttgact
      421 actggggcca ggcagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003798             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:9763:10416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003798
VERSION     KCXD01003798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:9763:10416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..451
     V_segment       76..375
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62280.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       380..396
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..451
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           98 a          137 c          116 g          102 t
ORIGIN      
        1 acatgggggt gccccaccat ggacacgctt tgctacacac tcctgctact gaccgtcccg
       61 tcctgggtct tgtcccaggt gaccttgaag gagtctggtc ctgcgctggt gaaacccaca
      121 cagaccctca cgctgacctg caccttctct gggttctcaa tcagtacttc tgcaacaggt
      181 gtgggctgga tccgtcagcc cccagggaag gccctggaat ggcttgcaag catttattgg
      241 aatgatacta aattcttcag cacttcgctg aagagcagac tcaccgtctc caaggacacc
      301 tccaaaaccc aggtggttct aacaatagcc aacatggacc ctgtggacac agccacatat
      361 tactgtgcac ggatacaggg tggtagttac tactacggtg ggggatactt cgagttctgg
      421 ggccagggcg ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003799             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:8977:11482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003799
VERSION     KCXD01003799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:8977:11482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62281.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          138 c          149 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggactga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagagc ttccagggca gagtcaccat gaccgaggac acgtctacag acacagctta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gtcaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003800             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6343:10177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003800
VERSION     KCXD01003800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6343:10177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62282.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          118 c          159 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcacagcctg
      181 gggggtccct gagactctcc tgttcagcct ctggattcac cttcagtaga cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctccggtatt aatagtggtg
      301 gggatactac atactacgca gactccgtga agggccgatt caccatgtcc agagacaact
      361 caaagaacac tctctccctg caaatgaaca gcctgagagc ggaggacacg gccgtgtatt
      421 attgtgtcca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003801             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17078:19116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003801
VERSION     KCXD01003801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17078:19116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62283.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          110 c          154 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaatacggta tatcttcaaa tgaacaacct gaaattggag gacacgtccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01003802             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15051:4484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003802
VERSION     KCXD01003802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15051:4484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62284.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       412..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           92 a          139 c          143 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcggga
      121 gtcgggccca gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtagta attggtggag ctggatccgc cagtccccag ggaagggact
      241 ggaatggatt gggggtatct atggtagtgg tgggaatacc gaatacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aggacacgtc caagaaccag ttctccctga agctgaactc
      361 tgtgaccgcc gcggacaccg ccgtgtatta ctgtacgaga gaatggggcg ctatagcggc
      421 agttgggcct gtccttgcct cctggggcca gggtgtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003803             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23180:4021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003803
VERSION     KCXD01003803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23180:4021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..484
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62285.1"
                     /translation="CARHRTSDYYSGSYPNPFRSFDFW"
     D_segment       408..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>490
                     /gene="IGHG"
BASE COUNT           94 a          152 c          140 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggagaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gactgggtac atcaatggcg ctagtgggag caccacctac aacccgtccc tccagagtcg
      301 agtcaccatt tccattgaca cgtccaagaa ccagttctcc ctgaggctga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagacatagg acgtcggatt actatagtgg
      421 cagttaccca aaccccttcc gctcctttga cttctggggc cagggagtcc tggtcaccgt
      481 ctccgcagcc
//
LOCUS       KCXD01003804             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5148:17063
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003804
VERSION     KCXD01003804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5148:17063"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62286.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       411..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          151 c          131 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtctccgg aaacaccttc accgaattgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ccgcatatgg tgaaatgacg
      301 ttccagggca gagtcatcat gaccgaggac acgtctacag acacagccta catggacctg
      361 accagcctga catctgacga cacggccgtc tattactgtg cggttggccc tagcggcact
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003805             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23607:13487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003805
VERSION     KCXD01003805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23607:13487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62287.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          134 c          132 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagt agtagctact ggaactggat ccgccagccc ccggggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgagtcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003806             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8366:11230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003806
VERSION     KCXD01003806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8366:11230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62288.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          111 c          155 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc cgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtacag cctctggatt catgttcagt aactatggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtcagtt atatcgtatg
      301 atgtaactgt gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cacgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgtgt gagggatgtc aggggaacgg ggtttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc gtcagcc
//
LOCUS       KCXD01003807             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:26066:16815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003807
VERSION     KCXD01003807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:26066:16815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62289.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          144 c          137 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cgttgatcct gcatatggtg aatttacacc
      301 cggagagaag ttccagggca gagtcaccat gaccgaggac tcgtctgtag acacagccta
      361 catggagctg agcagcctga attctgagga cacggccgtc tattactgtg cagccgggta
      421 tagcggcagc tggaaccact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01003808             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9317:9836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003808
VERSION     KCXD01003808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9317:9836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62290.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       425..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          117 a          144 c          134 g           99 t
ORIGIN      
        1 acatggggga acatcacaca acaaccacat ccctccccta cagaagcccc agagcgcagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttagt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg caatctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcagcgattt atccatacac tggatacgac
      241 aggcccctgg aaaagggctt cagtggatgg gaagtgttga tcctgctttt ggtgaaatga
      301 taaacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtct tcagacacag
      361 ccttcatgga attgagcagc ctgaaatctg acgacacggc cgtgtatttc tgtgcgagtg
      421 gccctagcgg cacctggatc gactggtcct tcgatgtctg gggccctggc accccaatca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01003809             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14854:9893
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003809
VERSION     KCXD01003809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14854:9893"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62291.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          104 a          128 c          159 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcccggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatactac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa cacgctctcc ctgcacatga acagcctgac agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01003810             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19847:19682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003810
VERSION     KCXD01003810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19847:19682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..341
     V_segment       7..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62292.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       290..295
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..341
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           77 a           81 c          103 g           82 t
ORIGIN      
        1 acatggtggg ggaggcttgg ttcagccggg ggggtccctg agactctcct gtgaagcctc
       61 tggattcacc ttcagtattt ctggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggagtgggtg gcagttaaat cgtttgatgg aactaagata tactacgcag actctgtgaa
      181 ggaccgattc accatctcca gagacaattc caagaacatg ctatatcttc aaatgaacaa
      241 cctgaaattg gaggacacgg ccgtttatta ctgtgtgaga gatgcctacg ggagcggttt
      301 ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01003811             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15730:16222
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003811
VERSION     KCXD01003811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15730:16222"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62293.1"
                     /translation="CARVGEDTGGAEDFDFW"
     D_segment       443..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          116 c          158 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggctcg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ccggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcactgata tcgtatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tttgtgcgag agttggagag gatactggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003812             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:27549:16457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003812
VERSION     KCXD01003812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:27549:16457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62294.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       440..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          105 a          120 c          155 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggtgaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt atttctacat
      241 gagctgggtc cgtcaggctc caggaaaggg gctggagtgg atctcaagta ttgacaatgg
      301 tgggactacc acaaattttg cagactccgt gaggggcagg ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttattgtgcg agagcgcgcg gggtgatcat tacatacttt gactcctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003813             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9376:17285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003813
VERSION     KCXD01003813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9376:17285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..500
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62295.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          118 a          141 c          143 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctgtggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcact atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgttgtca ccgtctcctc tgcc
//
LOCUS       KCXD01003814             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19826:11365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003814
VERSION     KCXD01003814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19826:11365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62296.1"
                     /translation="CARADRGSSIDFW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          117 c          146 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga gtgggtggcg gttatatctt
      301 atgatgatga taagaaatac tacacagact ctttgaagga ccgattcacc atatccagag
      361 acaattccaa gaacactctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagagcg gatcgcggca gttcaattga cttctggggc catggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003815             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24622:7476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003815
VERSION     KCXD01003815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24622:7476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62297.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          125 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 cattaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat accacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01003816             292 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12906:11842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003816
VERSION     KCXD01003816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 292)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 292)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12906:11842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..290
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..290
     V_segment       9..212
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <206..>259
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62298.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       217..231
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       243..290
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        291..>292
                     /gene="IGHG"
BASE COUNT           60 a           92 c           83 g           57 t
ORIGIN      
        1 acatggggcc aactactgga tcgcctgggt gcgccagatg cccgggaaag gcctggagtg
       61 gatggggatc atctatcctg gtgattctga caccaagtac ggcccgtcct tcgaaggcca
      121 ggtcaccatc tcagccgaca agtccaccag caccgcctac ctgcagtgga gcagcctgaa
      181 ggcctcggac accgccacgt attactgtgc gagactctgg ggtgattatt acgcactcca
      241 gtactacttc gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003817             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16069:11561
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003817
VERSION     KCXD01003817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16069:11561"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62299.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          116 a          143 c          129 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttccgg atacacctta accgaccact acctacactg ggtgcgacag
      241 actcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg taaagtagac
      301 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggagc tgaggagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga cttctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003818             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21473:20344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003818
VERSION     KCXD01003818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21473:20344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62300.1"
                     /translation="CAREYCTASSCAGFFDSW"
     D_segment       408..417
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          110 a          135 c          139 g          101 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa gtttcctgca
      181 aggcttctgg attcaccctc gacaactatg gtatcaactg ggtgcgacag gcccctggac
      241 aggggcttga gtggatggga gtgatcatcc cccttattgg aataataaac tacgaagaga
      301 acgtccagga cagagtcacg atttccgcgg acacgtccac aaacacagcc tacatggagg
      361 tgcgcagcct gacatctgag gacacggcca tctattactg tgcgcgagaa tattgtactg
      421 ctagcagttg cgccggattc tttgactcct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003819             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21179:12163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003819
VERSION     KCXD01003819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21179:12163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62301.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       459..466
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          107 a          139 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag taagaggttc aactggtgga gtctggagga gacttggtcc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttcctatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggtggtgg taccacatcc tacgcagact ccgtgaaggg ccgattcacc gtctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacagcct gagacctgac gacacggccg
      421 tgtattactg tgcgtcgaat ctacgtggta acacctacac ttactggcgg tcctttgact
      481 cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003820             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23763:12773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003820
VERSION     KCXD01003820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23763:12773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62302.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       412..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           98 a          136 c          141 g          106 t
ORIGIN      
        1 acatgggggc tccctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcgctg tctctggtta
      181 ctccatcaac agtggttact actactgggg ctggatccgt cagcccccag ggaaggggct
      241 ggagtggatt gggtatatag gtggtagtac tgggagcgcc tactacaacc ccgccctcaa
      301 gagtcgagtt gccatttcaa aagacacgtc caagaaccag ttctccctga agctgaggtc
      361 tgtgaccgcc gcggacacgg ccgtgtatca ctgtgcgaga catggaggtt tctatagtgc
      421 gactgacaag tcaacatttg acaactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01003821             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17196:19787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003821
VERSION     KCXD01003821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17196:19787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62303.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       431..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          112 c          148 g          119 t
ORIGIN      
        1 acatgggggg gagaggaacc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt attgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtagc tatggcttac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtctgatg
      301 aaagtaggaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag ggatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003822             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11013:16245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003822
VERSION     KCXD01003822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11013:16245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..468
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62304.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       409..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>472
                     /gene="IGHG"
BASE COUNT           92 a          141 c          131 g          108 t
ORIGIN      
        1 acatggggga tggtctctga gagtcatggg cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accaatacct actggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattgga tttatctatg gtgctactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc atctcaacag acacgtccaa gaaccagttt tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgcgagatat gatcagtggg atgattacct
      421 gtactacttt gactactggg gccagggagt cctggtcacc gtctcctcgt cc
//
LOCUS       KCXD01003823             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:11884:18105
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003823
VERSION     KCXD01003823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:11884:18105"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62305.1"
                     /translation="CARHGGSYYSNW"
     D_segment       401..415
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           93 a          131 c          129 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca tcagtaacta ctggagctgg atccgtcagc ccccagggaa gggactggag
      241 tggattgggt atacctatgg aagtggtagt aacactaact ataatccctc cctcaagagc
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagttct ccctgaagtt gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagacatg gtggtagtta ttactcgaac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003824             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6727:3163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003824
VERSION     KCXD01003824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6727:3163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62306.1"
                     /translation="CARNDYGNYDPLPHYW"
     D_segment       399..413
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           95 a          145 c          128 g           99 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccattag cagtaactac tggaactgga tccgccaacc accagggaag gggctggagt
      241 ggattgggta tatcggtggt actactggga tcacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaggctg agctctgtga
      361 ccgccgcgga cacggccgtt tattactgtg cgagaaacga ctacggtaac tacgaccctc
      421 ttcctcacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003825             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11193:21093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003825
VERSION     KCXD01003825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11193:21093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62307.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       430..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          114 a          132 c          148 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggccccagg aaaagggctt gagtggatgg gaagtgttga tcctgtatat ggtgaaataa
      301 ttgtcgcaga gaatttccag gacagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctggaatctg aggacacggc cgtgtattac tgtgcgaaag
      421 ggaggagtgg tggtgtctgg ccgagctcct tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctg cc
//
LOCUS       KCXD01003826             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:27366:6268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003826
VERSION     KCXD01003826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:27366:6268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62308.1"
                     /translation="CARDGPDGVAVTLFSLDVW"
     D_segment       457..464
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..516
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          110 a          120 c          156 g          132 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca attatatcgt
      301 atgatggaac taagaaatac ttcgcagatt ctgtgaaaga ccgattcacc gtctctagag
      361 acaattccaa gaacatgcta tttcttcacc tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagat gggcctgacg gtgtcgcagt aactctgttt tcattggatg
      481 tctggggccg gggagttctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003827             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20792:7510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003827
VERSION     KCXD01003827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20792:7510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..449
     V_segment       96..389
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62309.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       393..399
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       408..449
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>452
                     /gene="IGHG"
BASE COUNT          107 a          100 c          131 g          114 t
ORIGIN      
        1 acatgggggt gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg
       61 ttttccttgt tgctatttta agaggtgtcc ggtgtgaggt acaactggtg gagtctggag
      121 gaggcttggt tcaacctggg gggtccctga gactctcctg tgcagcctct ggattcacct
      181 tcagaaattt tggcatacac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
      241 cagttatttc gtctgatgga agtaacaaat actacgccaa ctctgtgaag agccgattca
      301 ccatttccag agacaattcc aagagcatac tatatcttca aatgaacaac ttgaaattgg
      361 aggacacggc cgtctattac tgtgcgagag atgatattgg gaccggtttt gactactggg
      421 gccagggagt cctggtcacc gtctcctcaa cc
//
LOCUS       KCXD01003828             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20796:15018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003828
VERSION     KCXD01003828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20796:15018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62310.1"
                     /translation="CARWESADFDYW"
     D_segment       398..403
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           93 a          127 c          134 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtgc
      181 ctccatcagc ggtggttatg gctggagctg gatccgtcag gccccagaga aaggactgga
      241 gtggattggg aatatctatg gatatagtgg tagcacaaac tacaacccct ccctcaggag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaaga tgagctctgt
      361 gaccgccgcg gactcggccg tgtattattg tgcgagatgg gagtcagcgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003829             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21321:6925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003829
VERSION     KCXD01003829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21321:6925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62311.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          136 c          137 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcac tgtctctggt
      181 ggctccttca gtggttacta ctggacctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttatcggtgg tggtagtggg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tgtcaagaga cacgtccaag aatcaattct ccctgaagat gacctctatg
      361 accgccgcgg acacggccgt ttatttctgt gccagagatg cgggagtggg agccacaatc
      421 ctttactact atgactactg gggccaggga gtccgggtca ccgtctcctc agcc
//
LOCUS       KCXD01003830             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12671:12606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003830
VERSION     KCXD01003830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12671:12606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62312.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          122 a          142 c          133 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca acgtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003831             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12049:15364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003831
VERSION     KCXD01003831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12049:15364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..457
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62313.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       374..395
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..457
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           94 a          127 c          132 g          106 t
ORIGIN      
        1 acatgggggt gcgagaacat gaagtatctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccagct gcagttgcag gagtcgggcc caggactgat gaagccttca
      121 gagaccctgt ccctcagctg cgctgtctct ggtggctcca taagtggtaa ctggtggagc
      181 tggatccgcc agcccccagg gaagggactg gactggattg gacgtatctc tggtactagt
      241 ggggacacca attacaatcc ctccctcaag agtcgagtca ccatttcaac agacacgtcc
      301 aagaaccact tctccctgaa gctgaactct gtgaccgccg cggacgcggc cgtgtattat
      361 tgtgcaagag cggattacga ggatgattac ggttatcatt taggatacaa ctggttcgat
      421 gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003832             530 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11022:18181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003832
VERSION     KCXD01003832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 530)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 530)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11022:18181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    147..528
                     /note="immunoglobulin heavy chain variable region"
     V_region        147..528
     V_segment       147..440
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <432..>497
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62314.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       450..456
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..528
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        529..>530
                     /gene="IGHG"
BASE COUNT          112 a          119 c          162 g          137 t
ORIGIN      
        1 acatggggga gctctgggag aggagccaca gccccgggat tcccagctgt ctccacttgg
       61 tcatgaacac tgaactcaga agacgcacca tggagtttgt gctgagtttg cttttccttg
      121 ttgctttttt aaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg
      181 taaagcctgg ggggtccctg agactctctt gtgtagtctc tggattctcc ttcagtaact
      241 atgttatgca ttgggtccgc caggctccag gaaagggtct ggagtgggtc tcacttatta
      301 gtggaagtgg tggtaccaca gactacgcag actctgtgaa gggccgattc accctctcca
      361 gagacaacgc caaggaatcg ctttttctgc aaatgaacag cctaagagcc gaggacacgg
      421 ccgtgtatta ctgtgctaga ggcggggaaa tagtggattc agagattatt gaggattact
      481 acggtttgga tttctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003833             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21027:12364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003833
VERSION     KCXD01003833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21027:12364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62315.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       405..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          138 c          136 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag ccacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc aacttctact ggaactggat ccgccagacc ccagggaagg ggctggagtg
      241 gattgggtgt atcagtggtg atagtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaacatt tcgacagaca ggtccaagaa acagttctcc ctgaagatga gttctatgac
      361 cgccgcggac acggccgtat attactgtgc gagagacccc cggtggcagc tggaacttct
      421 cttctttgac tattggggcc cgggagtcct ggttaccgtc tcctcagcc
//
LOCUS       KCXD01003834             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:24494:14461
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003834
VERSION     KCXD01003834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:24494:14461"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62316.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT          117 a          141 c          135 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagagt tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagttga gcagcctaag atctgaggac acggccctgt attattgtgc agtcgggtat
      421 agcggccgat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcggcc
//
LOCUS       KCXD01003835             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:12536:14637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003835
VERSION     KCXD01003835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:12536:14637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..498
     V_segment       135..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62317.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       442..447
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          122 c          152 g          120 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actctcctgc gcagcctctg gattcagctt cagttactac tacatgagtt
      241 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattgcc gctgatgggg
      301 atagcacata ctatgcagac tccatgaagg ccagattcac tatctccaga gagaacgcca
      361 agaacacact gcatcttcaa atggacagcc tgagagcaga ggacacggct gtctattact
      421 gtgtgagaga tcgacgtgtt cagtcgttat cctggttcga tgtctggggc ccgggagtcc
      481 tgatcaccgt ctcctcagcc
//
LOCUS       KCXD01003836             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:19007:12313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003836
VERSION     KCXD01003836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:19007:12313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62318.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          117 a          144 c          130 g           90 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg ggaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc acttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01003837             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21325:14578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003837
VERSION     KCXD01003837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21325:14578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62319.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          138 c          126 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctttgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003838             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11020:13932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003838
VERSION     KCXD01003838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11020:13932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62320.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       446..451
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatgttaag aggtgtccag tgtgaggtgc agatggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcat
      301 atgatgaaat tacgaaatac tacgcagact ctgcgaagga ccgattcacc atctccagag
      361 acaattccaa gaatgtggta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtatttctg tgcgagaggg gattttggta atggcgtcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01003839             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19817:5532
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003839
VERSION     KCXD01003839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19817:5532"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..483
     V_segment       102..394
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62321.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       409..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          103 a          119 c          145 g          118 t
ORIGIN      
        1 acatggggga cctggggatc agcactgaac acagaggacc caccatggag ttggggctga
       61 gctgggtttt ccttgttgct attttaaaag gtgtccagtg tgaggtgcaa ctggtggagt
      121 ctgggggagg cttggtccag cctggagggt ccctgagact ctcctgtgca gcctctggat
      181 tcaccttcag tagttacgac atgacctggg tccgccaggc tccgggaaag gggctggagt
      241 gggtctcata tattagttac actggtaaaa ccatatacta ctctgactcc gtgaagggcc
      301 gattcaccat ctccagagac aacgtcaaga actctctgtc tctgcaaatg agcagcctga
      361 gagccgagga cacggccgtg tattattgtt ctagagcggc ttacgaacat gatgacggtt
      421 actattacgt cggcaggttt tttgactgct ggggccaggg agccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003840             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21775:4722
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003840
VERSION     KCXD01003840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21775:4722"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62322.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       438..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          110 a          121 c          144 g          117 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgc tgctatttta
      121 agaggtgtcc agtgtgaggt ccacctggtg gaatctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagttcctt tggcatgcac
      241 tgggtccgcc aggcaccggg gaaggggctg gagtgggtgg cagttttatc gtctgatgga
      301 actaacaaat actacgcaga ctctttgaaa gaccgattca ccatatccag agacaactcc
      361 aagaacatac tatatcttca actgaacaac ctgaaattgg aggacacggc cgtgtattac
      421 tgtgcgagag atgtgtatgg ctcggggctt gactactggg gccagggagt cctgctcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003841             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12399:18911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003841
VERSION     KCXD01003841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12399:18911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..345
     V_segment       8..275
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <267..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62323.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       279..286
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..345
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           75 a           99 c           93 g           80 t
ORIGIN      
        1 acatgggagg acaggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
       61 actccatcag cagtagctac tggaattgga tccgccagcc cccagggaag ggactggagt
      121 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      181 gagtcaccat ttcaacagac atgtccaaga accagttttc cctgaggctg agttctgtga
      241 ccgccgcgga caccgccgtg tattactgtg tgagatatga ggatgaatcc attaactacc
      301 actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003842             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15956:3938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003842
VERSION     KCXD01003842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15956:3938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62324.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          121 a          141 c          127 g           99 t
ORIGIN      
        1 acatggggca acacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga accaccttca ccgaattatg cctgcactgg gttcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gttttaatcc tatatatggt gaaattttac
      301 aaacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta cccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01003843             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:25110:5300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003843
VERSION     KCXD01003843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:25110:5300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..336
     V_segment       6..274
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62325.1"
                     /translation="CAGGAYANLDYW"
     D_segment       285..289
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           74 a           93 c          102 g           69 t
ORIGIN      
        1 acatgggggg cggcttggca aagcctgggg ggtccctgag actctcctgt gcagcctctg
       61 gattcacctt cagtagatac tggatgaact gggtccgcca ggctccagga aaggggctgg
      121 agtgggtctc agctcttaat tatgatgggg atagtacata ctacgcagac tccgtgaagg
      181 gccgattcac catctccaga gacaactcaa agaacacgct ctccctgcaa atgcacagcc
      241 tgagagagga tgacacggcc gtatatttct gtgcgggcgg ggcgtacgct aacctcgact
      301 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003844             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:25563:6179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003844
VERSION     KCXD01003844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:25563:6179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62326.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          137 c          130 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acagtccctc cctcaagagt
      301 cgagtcacca tttcaactga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccat gtattactgt gtgagatatg aggatgagtc catcaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003845             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19560:14389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003845
VERSION     KCXD01003845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19560:14389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62327.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       404..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          141 c          131 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtgtcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtagcttct ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtct atctatggtg ctactgggag caccacctac aaccccgccc tcaagagtcg
      301 agtcaccatt tcaacagaga cgtccaagaa ccagttttcc ctgagactga gctctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gacgatgatt acggttccta
      421 ttaccttgac tactggggcc agggagtcct ggtccccgtc tcgtcagcc
//
LOCUS       KCXD01003846             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21096:16891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003846
VERSION     KCXD01003846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21096:16891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..286
     V_segment       7..225
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62328.1"
                     /translation="CARDVYGRGFDYW"
     D_segment       232..239
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       244..286
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           71 a           66 c           85 g           66 t
ORIGIN      
        1 acatggggat tcaccgtcag taactttggc gttcactggg tccgccaggc tccagggaag
       61 gggctggact gggtgacagt gatatcgtat gatggaaata agaaatacta cgcagagtct
      121 gtgaagggcc gattcaccat ctccagcgac acttccaaga acgtggtata tcttcaaatg
      181 aacaacctga aattggcgga cacggccgtg tattactgtg cgagagatgt ttacggtagg
      241 ggatttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003847             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5064:5438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003847
VERSION     KCXD01003847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5064:5438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62329.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          116 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaga caagagatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01003848             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6851:15540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003848
VERSION     KCXD01003848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6851:15540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62330.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaga agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggaact gagcagtctg agatctgagg acacggccgt atattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01003849             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18283:2279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003849
VERSION     KCXD01003849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18283:2279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..476
     V_segment       125..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62331.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       408..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          115 a          135 c          136 g           92 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcagagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctgatgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggttaccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaaggacttg agtggatggg aagtgttgat cctgtatatg gtgaaatgaa
      301 agagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 tagcctgaga tctgaggata cggccgtgta ttattgtgca gtcggcaata gcggcagctg
      421 gatctcctgg tccttcgatg tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01003850             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14401:11878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003850
VERSION     KCXD01003850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14401:11878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62332.1"
                     /translation="CAIGPSGTWNNWSFDIW"
     D_segment       414..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          105 a          141 c          137 g          100 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccttcttat gcagtctggg gctgaggtga tgcagcctgg ggcctcagtg
      181 aaggtctcct gcaagatttc cggatacacc ttcaccgagt tgtccattca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtgggtg gggagtgttg atcctgtata tggtgaaatg
      301 atgttccagg gcagagtcac catgaccgag gacacgtcta cagacacggc cttcatggag
      361 ctgagcagtc tgagctctga ggacacggcc gtgtattact gtgcgattgg ccctagcggc
      421 acctggaaca actggtcctt cgatatctgg ggccgtggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01003851             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8760:7230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003851
VERSION     KCXD01003851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8760:7230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62333.1"
                     /translation="CARGTRVWGYFPLDVW"
     D_segment       431..437
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..485
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          113 a          131 c          144 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctgttgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcctcac cgaattttcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ggatatggtg aaatgataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaattg agcagcctga gatctgagga cacggccgtc tattactgtg cgagaggcac
      421 aagggtgtgg ggttatttcc cgttggatgt ctggggccgg ggagttctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003852             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12327:16277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003852
VERSION     KCXD01003852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12327:16277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62334.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       452..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          117 c          153 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatgttaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg actgggtatc aggtattaac
      301 agtggcggtg acacatacta cccagactct gtgaagggtc gattcactat gtccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatagtg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003853             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18162:4661
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003853
VERSION     KCXD01003853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18162:4661"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62335.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          112 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggct ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg actccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaga tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003854             335 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:8450:4095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003854
VERSION     KCXD01003854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 335)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 335)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:8450:4095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..333
     V_segment       8..263
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <255..>302
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62336.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       267..274
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>335
                     /gene="IGHG"
BASE COUNT           71 a           99 c           88 g           77 t
ORIGIN      
        1 acatggggcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac tccatcagca
       61 atagctactg gaactggatc cgccagcccc cagggaaggg actggagtgg attgggtata
      121 tctctggtgc ttatgggagc accagctaca accccgccct caagagtcga gtcaccattt
      181 caacagacac gtccaagaac cagttttccc tgaggctgag ttctgtgacc gccgcggaca
      241 ccgccgtgta ttattgtgtg agatatgagg atgaatccat taactaccac tttgacttct
      301 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003855             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15970:20581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003855
VERSION     KCXD01003855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15970:20581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62337.1"
                     /translation="CASGPSGSWNDWYLDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          145 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccat
      121 tctgaggtcc agctggtgca atctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctttatatgg tgaaatgata
      301 cacacagaac agttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgatcagcct gagatctgag gacacggccg tgtattactg tgcgagtggc
      421 cctagcggca gctggaacga ctggtacctc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003856             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6759:8649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003856
VERSION     KCXD01003856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6759:8649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62338.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          144 c          134 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgtatatggt gaaatgatgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 gcagcctgac atctgacgac acggccgtct attactgtgc gattggccct agcggcagtt
      421 ggaaccactg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003857             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:19756:9360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003857
VERSION     KCXD01003857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:19756:9360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62339.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       415..421
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           82 a          138 c          144 g          100 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgaag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 tctccatcag cactcactcc tggagctggg tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtggtgggc gcacggacta caatccctcc ctcaagagtc
      301 gagtcacctt ttcaacagac acgtccagga accagttgtc cctgaggctg acgtctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagttga aagcgcctgg tccgtggggt
      421 gggattactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003858             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12289:9919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003858
VERSION     KCXD01003858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12289:9919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62340.1"
                     /translation="CARERFGGTGVIIYSWVDFW"
     D_segment       446..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          126 c          162 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttc ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcaacctc cggattcacc ttcagtgact tctacatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgtatta atcatgatgg
      301 tggtagcaca tggtacgcag actccgtgag gggcagattc accatctcca gagacaacgc
      361 caagaacaca ctgtatcttc aaatagacag cctgagacct gaggacacag ccgtgtattt
      421 ctgtgcgaga gagcggtttg ggggaactgg ggtgattatc tacagctggg tcgatttctg
      481 gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003859             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21529:18580
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003859
VERSION     KCXD01003859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21529:18580"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62341.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       445..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          100 a          125 c          162 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca cctggtggag tctgggggcg acttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcgg gtattgacag
      301 tggtgggggt accacatact atgccgactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccgag aacacgctgt atcttcagct ggacagcctg acagctgagg acacggctgt
      421 ctattactgt gcgagagtcg tgggtggtag tgctggatac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003860             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6527:14413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003860
VERSION     KCXD01003860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6527:14413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..278
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62342.1"
                     /translation="CATDAFGSGIDSW"
     D_segment       289..294
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           76 a           87 c          103 g           77 t
ORIGIN      
        1 acatggggga ggggccttgg ttcagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtacct atggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggagtgggtg gcggttatat cgaatgatga aagtaagaaa tactacgcag actctgtgaa
      181 ggaccgattc accatctcca gagacaattc gcagaacatg ctatatcttc aaatgaacac
      241 cctgaaattg gaggacacgg ccgtctactt ctgtgcgaca gatgcgtttg gtagcgggat
      301 tgactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003861             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23068:17177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003861
VERSION     KCXD01003861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23068:17177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62343.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          141 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagcccctg agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca acgtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01003862             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15622:17012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003862
VERSION     KCXD01003862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15622:17012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..450
     V_segment       87..379
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62344.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       386..395
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..450
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           98 a          104 c          141 g          109 t
ORIGIN      
        1 acatggggac tgaacacaga ggacccacca tggagttggg gctgagctgg gttttccttg
       61 ttgctatttt aaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggaggcttgg
      121 tccagcctgg agggtctctg agactctcct gtgtagcctc tggattcagc ttcagaagtt
      181 acgaaatgag ttgggtccgc caggctccgg gaaaggggct ggagtgggtc tcatatatta
      241 gtcacactgg tgaaaccata taccacgctg actccgtgaa gggccgattc accatctcca
      301 gagacaacgc caagaattcg ctgtctctgc aaatgagcag tctgagagcc gaggacacgg
      361 ccgtgtatta ctgtactaga aaccggaata ctgtaatgat tgggtggttc gatgtctggg
      421 gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003863             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18347:6219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003863
VERSION     KCXD01003863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18347:6219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62345.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       407..414
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..467
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          148 c          125 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtacaag aacatgcagt ttctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatt ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagt cgtaactggt ggagttgggt ccgccagccc ccaggcaagg gactggagtg
      241 gattggacgt atctctggta gtcttggaag caccagttac aatccctccc tcgagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt atttctgtgc gagacattca gaccccgcaa ctactagctg
      421 gtacttcgat ctctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01003864             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11847:18916
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003864
VERSION     KCXD01003864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11847:18916"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..480
     V_segment       117..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62346.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       413..421
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          110 a          140 c          131 g          101 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag cacctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccagctggt gcagtctggg gccgaagtga agaagcctgg ggcctcagtg agggtctcct
      181 gcaaggtttc cggacacacc ttcagcgaat tatccattca ctgggtgcga caggcccccg
      241 gaaaagggct tgagtgggtg ggaggttttg ctcctatata tggtgaaatc ctacacacag
      301 acaagttcca gggcagagtc accttgaccg aggacacgtc tacagacacc gcctatatgg
      361 agttgagcag cctgagatct gaggacacgg ccgtatatta ctgtgtggcg gctgatagtg
      421 gttacccttt ttactacttc gatatctggg gccctggcac cccaatcatc atctcctcag
      481 cc
//
LOCUS       KCXD01003865             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4112:9864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003865
VERSION     KCXD01003865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4112:9864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62347.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          139 c          135 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcactg tctctggtgg
      181 ctccttcagt ggttactact ggacctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggcttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa tcagttctcc ctgaagctga cctctatgac
      361 cgccgcggac acggccgttt atttctgtgc cagagatgcg ggagtgggag ccacaatcct
      421 ttactactat gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003866             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16509:7601
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003866
VERSION     KCXD01003866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16509:7601"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62348.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          118 a          146 c          141 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgagcaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gtaaatggtg aactaataca
      301 cgcagacaag ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga cacggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag cc
//
LOCUS       KCXD01003867             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:10324:16010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003867
VERSION     KCXD01003867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:10324:16010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..469
     V_segment       109..402
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62349.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       411..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           95 a          111 c          149 g          116 t
ORIGIN      
        1 acatggggag gtgtttctgt tcggcgatca gcactcgaca cagaacatac catggagttt
       61 gtgctgagct gggttttcct tgttgctctt ttgaaaggtg tccaatgtga ggtgcagctg
      121 gtggagtctg ggggcggctt ggcaaagcct ggggggtccc tgagactctc ctgcacagcc
      181 tctggattca gcttcagtta ctattacatg acctgggtcc gccagcctcc agggaagggg
      241 ctggagtgga tctcgggtat tgacagtggg gggggtagtg catactatcc agactccgtg
      301 aagggcagat tcaccatctc cagagagaac gccaagaaca cactgtttct tcaaatggac
      361 agcctgagac ctgaagacac ggctgtctat tactgtgcga gagtcgtggg tggtagtgct
      421 ggatactttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003868             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16502:18487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003868
VERSION     KCXD01003868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16502:18487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62350.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          116 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 aaactaagaa atattacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003869             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8708:12863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003869
VERSION     KCXD01003869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8708:12863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62351.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       406..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          136 c          139 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccagg tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgag gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 gactccttca gcggttacta ctggagctgg atccgccagt ccccagggac ggggctggag
      241 tggattgggt atatcagtgc tagtagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagaga aatattatag tggtagttat
      421 aaacacaact ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003870             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20708:3883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003870
VERSION     KCXD01003870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20708:3883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62352.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          112 a          122 c          146 g          130 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagctt ctggtggagt ctgggggagg cttggtacag
      181 cctggggcgt ccctgagact ctcctgtgca gcctctgaat tcaccttcag tggctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctagaat gggtatcagg tattaacatt
      301 ggcggtgacc catactaccc agactctgtg aagggtcgat tcaccatctc cagagacaac
      361 gccgagaact ccttgttcct tcaaatgaac aacctgagac ctgaggacac tgctgtgtat
      421 tattgtgtga gggggatgga taactaccac ttcagtaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003871             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10258:17086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003871
VERSION     KCXD01003871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10258:17086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62353.1"
                     /translation="CAGAHSGSWTNWSFDLW"
     D_segment       423..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          141 c          146 g           91 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggagggtcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagccagggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatattcggt caccgaagtg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctctatatg gtgaaataat
      301 agaaggagag aagttcccgg gcagagtcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgggagc
      421 ccatagcggc agctggacca actggtcctt cgatctctgg ggccctggca ctccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01003872             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16061:4987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003872
VERSION     KCXD01003872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16061:4987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62354.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       438..450
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          116 c          150 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg agtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag tctctggatt caccttcagt agctttggca
      241 tgcattgggt ccgccagact ccagggaagg ggctggagtg ggtggcagtt atgtcgtctg
      301 atggaagtta caactactac gcagactcta tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa caccctatat cttcaaatga acaacctgaa gttggaggac acggccgtgt
      421 attactgtgc gagaggggaa tacagtaact ctattgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003873             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21396:20010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003873
VERSION     KCXD01003873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21396:20010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..363
     V_segment       1..287
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <279..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62355.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       293..312
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       314..363
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           72 a          105 c          105 g           83 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg
       61 tctctggtgg ctccatcagc agtagtacct ggtggaactg ggtccgccag cccccaggga
      121 aaggcctgga gtggatagga tatatcaatg gtgagagtgg tagcacctac tacaatccct
      181 ccctcgagag tcgaatcacc atttcaacag acacgtccac gaaccagttt tccctgaggc
      241 tgagctctgt gaccgccgcg gacacggccg tgtatttctg tgcgagaggt tcctatagtg
      301 gtagttatta cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01003874             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22871:5684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003874
VERSION     KCXD01003874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22871:5684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62356.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          122 c          147 g          129 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003875             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13684:14770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003875
VERSION     KCXD01003875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13684:14770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62357.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       397..404
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           92 a          136 c          127 g          110 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagt tcccagatgg gtcctgtccc aggtgcagct gctggagtcg
      121 ggcccgggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagca ctagttactg gaactggatc cgccagcccc cagggaaggg actggagtgg
      241 attgggtata tctctggtgc ttatgggagc accagctaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cacttttccc tgaggctgag ttctgtgacc
      361 gccgcggaca ccgccgtgta ttattgtgtg agatatgagg atgaatccat taactaccac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003876             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16579:9359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003876
VERSION     KCXD01003876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16579:9359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62358.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       446..450
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          153 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatctcat
      301 ttgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaca tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggga cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003877             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24603:18199
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003877
VERSION     KCXD01003877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24603:18199"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62359.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          139 c          150 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcact gtctcctcag cc
//
LOCUS       KCXD01003878             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:27340:8601
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003878
VERSION     KCXD01003878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:27340:8601"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62360.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       409..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          136 c          129 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtaacttct ggatctggat ccgccagccc ccagggaagg ggctggagtg
      241 gatagggtct atctatggta gtactgggag caccttttac gacccctccc tcaagggtcg
      301 agtcaccatt tcaacagaca cgtccaagaa cctattttcc ctgaagctgg actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatagc gatactgata gttattactt
      421 ctttgactac tggggccagg gagtccgggt caccgtctcc tcagcc
//
LOCUS       KCXD01003879             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25474:19981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003879
VERSION     KCXD01003879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25474:19981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62361.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          119 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatccactg ggtccgccag gctccagtga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003880             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16363:6428
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003880
VERSION     KCXD01003880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16363:6428"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62362.1"
                     /translation="CSRDPVDCSGSDCYAFDSW"
     D_segment       425..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          120 a          142 c          132 g          101 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaat tggtgcagtc tggggctgag actaagcagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata tagtttcact aactaccaca tgcactgggt gagacaggcc
      241 cctggacaag gcctagagtg gataggactg atctcccctt acaatggtta caaagcctac
      301 gcacagaact tccagggcag agtcaccata actgcggaca cgtccacgag cacaggctac
      361 atggagctga gcagcctgag atctgaggac acagccgtgt attactgttc gagagaccca
      421 gtagactgtt ctgggagtga ttgctacgcc tttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003881             442 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:11238:14329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003881
VERSION     KCXD01003881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:11238:14329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..440
     V_segment       89..378
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>409
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62363.1"
                     /translation="CASNSITSGPDYW"
     D_segment       384..390
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>442
                     /gene="IGHG"
BASE COUNT           84 a          138 c          123 g           97 t
ORIGIN      
        1 acatgggacg gacatcctgt gcaagaacat gaggcacctg tggttcttcc tcctcctggt
       61 ggcagctccc agatgggtcc tgtcccgcct gcagctgcag gcggcgggcc caggactggt
      121 gaagccttcg gagaccctgt ctctcacctg cgctgtctct ggtggctcta tcagcggtaa
      181 ctactggagc tggatccgcc gggccccagg gaagggactg gagtggattg gatatatcta
      241 cggtagtgat tttaccacca actacaaccc ctccctcaag agtcgagtca ccctgtcagc
      301 agatacgtcc aagaaccagc tctccctgaa cctggcctct gtgaccgccg cggacacggc
      361 cgtctatttc tgtgccagta atagtataac atctggtcca gattactggg gccggggagt
      421 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003882             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7088:17552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003882
VERSION     KCXD01003882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7088:17552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62364.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           98 a          143 c          134 g          111 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt tccagttact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tactaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagtcg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaagggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01003883             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23165:14212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003883
VERSION     KCXD01003883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23165:14212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..510
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62365.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       445..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          118 a          110 c          157 g          127 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgctgc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cagtttcagt ggctttggca
      241 tacactgggt ccgccaggct cctgggaagg ggctggagtg ggtgtcactt atatcgtatg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcatcatg tccagagaca
      361 attccaagaa caaggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagagttagt ggtcatacag agggtacagt tgaaaacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003884             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20710:5418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003884
VERSION     KCXD01003884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20710:5418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..484
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62366.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       423..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          121 a          137 c          133 g           95 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccaggtgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacat cttaaccgaa ttatccatac actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggaagtgtt gatcctcaat atggtgaaat gatagacgca
      301 gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac agcctacatg
      361 gagctgagta gtctgagatc tgaggacacg gccgtgtatt actgtgcgac atcatccagc
      421 ggcacctggc tatactggta cttcgatatc tggggccctg gcaccccaat caccatctcc
      481 tcagcc
//
LOCUS       KCXD01003885             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16846:19282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003885
VERSION     KCXD01003885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16846:19282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..394
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62367.1"
                     /translation="CAKKYSGSYFYGHYDYW"
     D_segment       400..415
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          100 a          133 c          131 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatca gtgattactg gtggaactgg atccgccagc caccagggaa gggactggag
      241 tggattgcgg agatcaatgt tgatagtggt accacctact acaacccctc cctcaatagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccagttct ccctgaaggt gacttctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgaaaaagt atagtggcag ttatttctac
      421 ggacactatg actactgggg ccagggagtc ttggtcaccg tctcctcagc c
//
LOCUS       KCXD01003886             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:5428:9179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003886
VERSION     KCXD01003886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:5428:9179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..445
     V_segment       79..370
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62368.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       384..390
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..445
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          106 a          121 c          128 g           92 t
ORIGIN      
        1 acatggggac agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca
       61 gctacaggcg cccactctga ggtccacctg gtgcagtctg gggctgaggt gaagaagcct
      121 ggggcctcag tgaaggtctc ctgcaaggtt tccggataca tcttaaccga attatccatc
      181 cactgggtgc gacaggcccc tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa
      241 tatggtgaaa tgatagacgc agagaaattc cagggcagag tcaccatgac cgaggacacg
      301 tctacagaca cagcctacat ggagctgagt agtctgagat ctgaggacac ggccgtgtat
      361 tactgtgcga catcatccag cggcacctgg ctatactggt acttcgatat ctggggccct
      421 ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01003887             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6232:5603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003887
VERSION     KCXD01003887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6232:5603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62369.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       407..419
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           91 a          145 c          124 g          110 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacgtgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 tctccatcaa cgattaccat tggagctgga tccgccagcc ccctgggaag ggactggagt
      241 ggattggaca tatctctcat agtcgtggaa gcaccgacta caacccctcc ctcaagagtc
      301 gcgtcaccat ttcaacagac acgtccaaga accagttctc cctgaagctg agctctatga
      361 cccccgcgga cacggccgtc tattactgtg cgagagatca ggattcttac gtttactatc
      421 gcttctttga cttctggggc cagggagtcc tgctcgccgt ctcctcagcc
//
LOCUS       KCXD01003888             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22929:6609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003888
VERSION     KCXD01003888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22929:6609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62370.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          147 c          143 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cactgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc attcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agcgcctggt ccaacctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003889             390 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22259:19230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003889
VERSION     KCXD01003889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 390)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 390)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22259:19230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    16..388
                     /note="immunoglobulin heavy chain variable region"
     V_region        16..388
     V_segment       16..308
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <307..>357
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62371.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       319..328
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       346..388
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        389..>390
                     /gene="IGHG"
BASE COUNT           95 a           89 c          116 g           90 t
ORIGIN      
        1 acatggggcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt ccagcctggc
       61 gggtccctga gactctcctg tgcagcctct ggattcacct tcaatgagta tgccatgagc
      121 tgggtccgcc aggcttctgg gaaaggactg gagtggattg gctatattag aagcaaatat
      181 aacgattacg cgacagaata tgccgcatcg gtgaaaggca gattcaccat ctccagagat
      241 gattcaaaga acacactata tctgcagatg agcagcctga aaaccgagga gacggccgtg
      301 tattactgca cccgtctcta tagtgggaac tatagaatta tgatgtttga ctactggggc
      361 cagggagtcc tggtcagtgt ctcctcagcc
//
LOCUS       KCXD01003890             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21140:12135
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003890
VERSION     KCXD01003890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21140:12135"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62372.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       431..439
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          142 c          144 g           98 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcggctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttt agcatccatg gcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tttaacacac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgcccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggcct tttattactg tgcgagaggg acaacccacc
      421 tcgagatggc aactggaatc ggagactact ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003891             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:25613:17264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003891
VERSION     KCXD01003891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:25613:17264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62373.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          127 a          144 c          130 g           91 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagattc accgaatcat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga atggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacacagaga aattccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggatc tgaacaccct gagatctgac gacacggcca tctattactg tgcgagagcc
      421 catagcggca gctggaataa ctggtacttc gatctctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01003892             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:20762:10330
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003892
VERSION     KCXD01003892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:20762:10330"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62374.1"
                     /translation="CTRADRGSSIDFW"
     D_segment       439..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          114 c          145 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aagactcacc atgaagtttg ggctgagctg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct aagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcttgc
      241 actgggtccg ccagggtcca gggaaggggc tggaatgggt ggcggttata tcttatgatg
      301 atgataagaa atactacaca gactctttga aggaccgatt caccatatcc agagacaatt
      361 ccaagaacac tctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtacgag agcggatcgc ggcagttcaa ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003893             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:22462:4733
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003893
VERSION     KCXD01003893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:22462:4733"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62375.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       409..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          149 c          130 g           94 t
ORIGIN      
        1 acatgggcat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacatt
      301 ccagggcaga gtcttcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      361 cagcctgaca tctgacgacg cggccgtcta ttactgtgcg gttggcccta gcggcacttg
      421 gaaccactgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01003894             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21632:11233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003894
VERSION     KCXD01003894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21632:11233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62376.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          143 c          137 g          100 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtctccag
      121 tcccaggtcc acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgacg
      181 gtttcctgcg gggcctctgg attcaccttc gacacccatg gaatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccttattgg tatcacaaac
      301 tacgcaaaga actctcaggg cagagtcaca ataaccgcga acacgtccac aaacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggcca tctattattg tgcgagagaa
      421 tactgtactt ctagtagttg cgccgggttc cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01003895             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14053:2238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003895
VERSION     KCXD01003895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14053:2238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62377.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          143 c          143 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg gctgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc atgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003896             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:22202:5349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003896
VERSION     KCXD01003896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:22202:5349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..345
     V_segment       8..290
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62378.1"
                     /translation="CARWGTPFDFW"
     D_segment       291..295
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..345
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           66 a          105 c          101 g           75 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcacctgcg
       61 ctgtctctgg tagctccatc aacagtggtt atgcctggag ttggatccgc cagcccccag
      121 ggaaggggct ggagtgggtt gggcatttct atgatagtag tgggaacacc tactacaacc
      181 cctccctcaa gagtcgagtc accatttcaa aggacacgtc caagaaccaa ttctccctga
      241 agctgacctc tgtgaccgcc gcggacacgg ccgtctattt ctgtgcgaga tgggggaccc
      301 cctttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003897             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10407:9266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003897
VERSION     KCXD01003897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10407:9266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62379.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          121 c          145 g          128 t
ORIGIN      
        1 acatgggggg gagaagagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcttctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 gagaactcct tgttccttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003898             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9012:9344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003898
VERSION     KCXD01003898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9012:9344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62380.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          113 a          141 c          132 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagttggta cagtctgggg ttgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg agaaggactt gagtggatgg gaggtgttca tcctgaattt ggtaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01003899             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12055:7884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003899
VERSION     KCXD01003899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12055:7884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62381.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       262..274
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           76 a           76 c           96 g           73 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagtctctg gattcacctt cagtagcttt
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgacatcg
      121 tatgatggaa gttggaagta ctacggagac tctgtgaggg accgattcac catctccaga
      181 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtatattact gtgcgagagg ggaatacagt aactctgttg actactgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003900             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:19735:13874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003900
VERSION     KCXD01003900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:19735:13874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..440
     V_segment       87..378
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62382.1"
                     /translation="CATADYGNSLDYW"
     D_segment       384..395
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>443
                     /gene="IGHG"
BASE COUNT           99 a          106 c          129 g          109 t
ORIGIN      
        1 acatgggcac agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg
       61 ttgctatttt aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg
      121 ttcagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagct
      181 ttggcatgca ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt
      241 cgtctgatgg aagtatgaaa tactacgcag actctatgaa ggaccgcttc accatctcca
      301 gagacaattc caagaacata ctatatcttc aaatgaagac cctgaaattg gaggacactg
      361 ccgtttatta ctgtgcgaca gccgactacg gtaacagcct tgactactgg ggccagggag
      421 tcctggtcac cgtctcctca acc
//
LOCUS       KCXD01003901             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19180:3448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003901
VERSION     KCXD01003901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19180:3448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62383.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          147 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacacagact ctgtgaagag ccgattcacc atctccagag
      361 acaattccca gaacatactt tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003902             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15673:6981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003902
VERSION     KCXD01003902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15673:6981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62384.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          114 c          151 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaaca aagaaatact acgcagactc tctgaaggac cgcttcatca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaataacctg aaattggatg acacggccgt
      421 atattactgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggtgtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003903             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:27356:6790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003903
VERSION     KCXD01003903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:27356:6790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62385.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          134 c          137 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccttcagc ggtttctatt ggagctggat ccgccagtcc ctagggaagg gactggagtg
      241 gattgggtat atcagtgcta gtagtgggag taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaataa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtccaggtc accgtctcct cagcc
//
LOCUS       KCXD01003904             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20295:13381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003904
VERSION     KCXD01003904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20295:13381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62386.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          116 c          149 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 caacctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaatttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa gtcacaaata ctacgccaac tctgtgaaga gccgattcgc catctccaga
      361 gacaattcca agaacatact atatcttcaa atgaacaact tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatattggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003905             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20411:7473
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003905
VERSION     KCXD01003905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20411:7473"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62387.1"
                     /translation="CARVDTSTLDATAADYW"
     D_segment       437..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          116 a          119 c          152 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatcttca gtacctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatatcgtt
      301 tgatggaagt aagcaatatt acgcagactc tgtgaaggac cgattcacca tctctagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gcgagagtgg atacatctac acttgatgca acagcagctg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003906             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21034:13852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003906
VERSION     KCXD01003906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21034:13852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62388.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       430..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          108 a          113 c          154 g          115 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agccgggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt ctgatgaaag
      301 taagaaatac tacgcagact ctgtgaaggc ccgattcacc gtctccagag acaactccaa
      361 gaacatgtta tatcttcaaa tggacaacct gaaattggaa gacacggccg tgtattactg
      421 cgcgagagat gtctggggga ggggatttga ctattggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003907             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22372:5808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003907
VERSION     KCXD01003907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22372:5808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..498
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62389.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       425..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          143 c          144 g          103 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatccacct tcaccgaatt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttgc tcctctatat ggtgaaatga
      301 tgctcgcaga caacttccag ggcagagtca ccttgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg acgacacggc cgtgtattac tgtgcgcgtg
      421 ggcctattac aatttttggc gtacttatta cggggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003908             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21953:10620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003908
VERSION     KCXD01003908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21953:10620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..442
     V_segment       88..381
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62390.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       384..388
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           95 a          101 c          139 g          109 t
ORIGIN      
        1 acatggggca cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt
       61 gctgttattt taagaggtgt ccagtgtgac gtgcagctgg tggagtctgg aggaggcttg
      121 gttcagcctg gggggtccct gagactctcc tgtgcaggtt ctggattcac cttcagtaac
      181 tttggcatgc actgggtccg ccaggctcca gggaaggggc tggactgggt ggctgttatg
      241 tcgtctgatg gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc
      301 agagacaatt ccaagaacat ggtatatctt caagtgaaca ccctgaaatt ggaggacacg
      361 gccgtgtatt actgtgcgag agatgtcttt ggcgggggac ttgactactg gggccaggga
      421 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01003909             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4925:4927
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003909
VERSION     KCXD01003909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4925:4927"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    52..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        52..430
     V_segment       52..343
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <337..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62391.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       366..372
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       381..430
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT           97 a          113 c          133 g           89 t
ORIGIN      
        1 acatggggga ggatcctcct cttggtggca gcagctacag gcgcccactc tgaggtccaa
       61 ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt ctcctgcaag
      121 gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc ccctggaaaa
      181 gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca cgcagagaaa
      241 ttccagggca gagtcaccat gaccgaggac acgtccacag acacagcctt catggagttg
      301 agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg gttcggaacc
      361 agcgtctggt ccaacctctt ctacggcttg gattcttggg gccaaggggt cgtcgtcacc
      421 gtctcctcag cc
//
LOCUS       KCXD01003910             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19997:15911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003910
VERSION     KCXD01003910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19997:15911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62392.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          134 c          130 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactgc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003911             360 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17867:15765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003911
VERSION     KCXD01003911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 360)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17867:15765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..358
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..358
     V_segment       8..283
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <277..>327
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62393.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       297..303
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..358
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        359..>360
                     /gene="IGHG"
BASE COUNT           91 a           91 c          103 g           75 t
ORIGIN      
        1 acatgggagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag
       61 gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc ccctggaaaa
      121 gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga cgcagagaaa
      181 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      241 agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc cagcggcacc
      301 tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003912             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10065:3775
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003912
VERSION     KCXD01003912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10065:3775"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..493
     V_segment       113..404
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62394.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       413..435
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          109 a          136 c          145 g          109 t
ORIGIN      
        1 acatgggaac cacgtccctc ctctaaagaa gcccctggga acacagctca tcaccatgga
       61 cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt cccaggtcca
      121 cctggtgcag tccggggctg aggtgaagag gcctggggcc tcagtgaagc tctcctgcaa
      181 ggcttctgga tacaccttca gcatctctgc catcagttgg gtgcgacagg cccctggaca
      241 aggacttggg tggatgggag ggatcatccc tcttgttggt atgacaaact acgaacagaa
      301 gttccagggc agagtcacga ttaccgcgga cacgtccacg aatacagtct tcatggaact
      361 gagcagcctg agatctgagg acacggccgt ctactattgt gcgacagggg tatattacca
      421 ggatgaatac ggttattttt atgtcggcgg tgactttgac tactggggcc agggagtcct
      481 ggtcaccgtc tccccagcc
//
LOCUS       KCXD01003913             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:8911:10022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003913
VERSION     KCXD01003913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:8911:10022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62395.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       398..406
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           97 a          133 c          130 g          115 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgttc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccaa atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agaagtaact actggagctg gatccgccag tccccaggga agggactgga
      241 gtggataggt tatgtctatg gtgatagtgg gaacaccgaa tacaacccct ccctcaagag
      301 tcgagtcacc atttcaagag actcgtccaa gaatcagttt tccctgaagc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtatcactg tgcgagatac agttacggtt ccaactactt
      421 ctttgggttc tttgactatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003914             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21187:3089
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003914
VERSION     KCXD01003914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21187:3089"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62396.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       440..444
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          114 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccatccg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttatc tcatttgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt cacatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg gggacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003915             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22075:15981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003915
VERSION     KCXD01003915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22075:15981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..450
     V_segment       96..389
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62397.1"
                     /translation="CVRDASGSGLDSW"
     D_segment       396..402
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..450
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT          107 a           94 c          138 g          113 t
ORIGIN      
        1 acatgggggt gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg
       61 ttttccttgt tactatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag
      121 gaggattggt tcagcctggg gggtccctga gactctcctg tgtagcctct ggattcacct
      181 tcagcagtag tggcatgcac tgggtccgtc aggctccagg gaaggggctg gagtgggtga
      241 cagttatatc gtatgatgaa aataagaaat actacgcaga ctctgtgaag gaccgattca
      301 ccatctccag agacaattcc aagaacatgg tatttcttca aatgaacaac ctgaaaatgg
      361 aagacacggc cgtgtattat tgtgtgagag atgcgagtgg ttccggtttg gattcctggg
      421 gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01003916             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10780:12297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003916
VERSION     KCXD01003916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10780:12297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62398.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          144 c          134 g           95 t
ORIGIN      
        1 acatggggga cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gtatatggtg aaatgatgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggagctgag
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg attggcccta gcggcagttg
      421 gaaccactgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01003917             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11748:5900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003917
VERSION     KCXD01003917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11748:5900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62399.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          117 c          161 g          111 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gtggctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctcaactagt aatagtggtg
      301 gggataacac atattacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctcctcctg caaatgaaca gcctgagagt ggaggacacg gccgtgtatt
      421 actgtgttca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003918             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15174:7190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003918
VERSION     KCXD01003918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15174:7190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62400.1"
                     /translation="CAREFSPYDYFWSDFYSYYFDYL"
     D_segment       432..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           97 a          145 c          133 g          115 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tgactccttc agcggttact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg catatcagtg ggagtagtgg gagcaccgac tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaacag acacgtccaa gagccacttc tccctgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag ttttccccct acgactattt
      421 ttggagtgat ttttactctt actactttga ctacttgggc cagggactcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01003919             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:12981:11170
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003919
VERSION     KCXD01003919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:12981:11170"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..454
     V_segment       91..383
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62401.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       396..404
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           93 a          129 c          135 g           99 t
ORIGIN      
        1 acatggggag tcacggacat cctgtgcaag aacatgaagc acctgtggtt cttcctcctc
       61 ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc gggcccagga
      121 ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg gtctatcaga
      181 agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg gattgggtat
      241 atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg agtcaccctg
      301 tcagtagaca cgtccaagaa ccagtgctcc ctgaagttga gcgctgtgac cgccgcggac
      361 acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag cattgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003920             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16971:16243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003920
VERSION     KCXD01003920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16971:16243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62402.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          117 c          148 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003921             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14809:9707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003921
VERSION     KCXD01003921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14809:9707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62403.1"
                     /translation="CARKWAGYGLDSW"
     J_segment       407..455
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           93 a          132 c          132 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggagcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccctcagc ggttactact ggaattggat ccgccaacca ccagggaagg ggctggagtg
      241 gattggttat atcgctggta gtagtggaag taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaggaa ccagttctcc ctgaaactga cctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc aagaaaatgg gccggatacg gtttggattc
      421 ctggggccaa ggggtcgtcg ttacagtctc ctcagcc
//
LOCUS       KCXD01003922             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:25362:7770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003922
VERSION     KCXD01003922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:25362:7770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..420
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62404.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       446..450
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          138 c          144 g          102 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaagtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaagtttc cggatacacc ttcaccgatt tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg atactgtatc tgatggagtg
      301 atatacgcag agaacttcca gggcagagtc gccatgaccg aggacacgtc tacagacaca
      361 gcctacatgg aattgagcag cctgagatct gaggacacgg ccgtttatta ctgtgcgaga
      421 ggtttatcac cagacgtctt cggtttcctc gggcttggct actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003923             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13317:7241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003923
VERSION     KCXD01003923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13317:7241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62405.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          107 a          140 c          147 g          107 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata cagcttcagc atctatgtca tcagttgggt gcgacgggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggca atggttgtaa ccttactttc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01003924             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17485:4804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003924
VERSION     KCXD01003924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17485:4804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..378
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62406.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       382..394
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT          100 a           98 c          130 g          113 t
ORIGIN      
        1 acatgggcag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtcgggagg aggcttggtt
      121 cagcctgggg ggtccctgag actctcctgt gtagcctctg gattcacctt cagtcttttt
      181 ggcatgcact gggtccgcca ggctccaggg aaggggctgg attgggtggc agttatgtcg
      241 tttgatgaaa atacgaaata ctacgcagac tctgtgaagg gccgattcac catctccaga
      301 gacaattcca agaacatgtt atatcttcaa atgaataacc tgcaattgga ggacacggcc
      361 ctgtattact gtgcgagagg agaatacagt aactctattg actactgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003925             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:15156:2610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003925
VERSION     KCXD01003925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:15156:2610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62407.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       443..448
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          110 a          113 c          153 g          120 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaagac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctac
      121 tttaagaggt gtccagtgtg acgtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gttttggcat
      241 acactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tttcgtatga
      301 tgaaactaag aaattttacg cagactctgt gaaggaccga ttcaccctct ccagagacaa
      361 ttccaagaat atgctatatc ttcaaatgaa caacctgaaa ctggaggaca cggccgtgta
      421 tttctgtgcg agagatgtca ggggaacggg gtttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01003926             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20076:8048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003926
VERSION     KCXD01003926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20076:8048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62408.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          139 c          149 g           98 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tgggactgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gaaatgtcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagagct tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gacagggagg
      421 ttcgggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg tcaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01003927             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16582:5699
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003927
VERSION     KCXD01003927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16582:5699"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62409.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          119 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggact gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003928             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22995:11257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003928
VERSION     KCXD01003928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22995:11257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62410.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          148 c          146 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc acccaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggatggga cttgttgatc ctgtcaatgg tgaagaaata
      301 cacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcggctg gtccagcctc ttcaccggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01003929             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17484:15677
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003929
VERSION     KCXD01003929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17484:15677"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62411.1"
                     /translation="CARYEGAAAGTWYFDNW"
     D_segment       404..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           88 a          140 c          137 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccgtcagc aattccttct ggaactggat ccgccagccc ccagggaagg gcctggagtg
      241 gattggatat atctatggta gtagtgggag caccggctac aacccctccc tccagggtcg
      301 agtcaccatt tcaacagaca cgtccaacaa ccaggtttcc ctgaagctga gctctgtgac
      361 cgccgcggac accgccgtgt ttttttgtgc gagatatgag ggggcggcag ctggaacctg
      421 gtactttgac aactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003930             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10133:2934
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003930
VERSION     KCXD01003930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10133:2934"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <435..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62412.1"
                     /translation="CTTSSWNDDFW"
     D_segment       447..458
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          121 a          121 c          144 g          114 t
ORIGIN      
        1 acatggggct ctgggagagg agacccagcc ttgggatttc cagctgtctc cacttggtga
       61 tcagcactga acacaggaga ctcgccatgg agtgtgtact gagctgggtt ttccttgttg
      121 ctataataaa aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtcc
      181 agcctggcgg gtccctgaga atctcctgtg cagcctctgg attcctcttc agtgactatg
      241 ccatgaactg ggtccgccag gcttctggga aaggactgga gtggattggc tatattagaa
      301 acaagtataa caattacgcg acagaatacg ccgcatcggt gaaaggcaga ttcaccatct
      361 ccagagatga ttcaaagaac acggtatatc tgcaaatgag tagcctgaaa accgaggaca
      421 cggccatata ttactgcacc acatccagct ggaacgacga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003931             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7204:7515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003931
VERSION     KCXD01003931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7204:7515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..378
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62413.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       381..386
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           98 a           97 c          138 g          108 t
ORIGIN      
        1 acatgggcag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      121 cagccggggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtactttt
      181 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttacatcg
      241 tctgatgaaa gtaataaata ctacgcagac tctgtgaagg cccgattcac cgtctccaga
      301 gacaattcca agaacatgtt atatcttcaa atggacaacc tgaaattgga agacacggcc
      361 gtgtattact gcgcgagaga tgtctggggg aggggatttg actattgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003932             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19234:8469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003932
VERSION     KCXD01003932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19234:8469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62414.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003933             315 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24429:15329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003933
VERSION     KCXD01003933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 315)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 315)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24429:15329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..313
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..313
     V_segment       8..237
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>282
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62415.1"
                     /translation="CARERCSTSSCAGFLDSW"
     D_segment       252..257
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..313
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        314..>315
                     /gene="IGHG"
BASE COUNT           70 a           89 c           91 g           65 t
ORIGIN      
        1 acatggggca aggcttctgg attcaccctc gacaactatg gcatcaactg ggtgcgccag
       61 gcccctggac aggggcttga gtggatggga gtgatcatcc cccttattgg aataataaac
      121 tacgcagaga acgtccaggg cagagtcgcg atttccgcgg acacgtccat acatacagcc
      181 tacatggagg tgcgcagcct gagatctgag gacacggcca tctattactg tgcgcgagaa
      241 cgttgttcca ctagcagttg cgccggattc ctagactcct ggggccaggg agtcctggtc
      301 accgtctcct cagcc
//
LOCUS       KCXD01003934             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:19061:17390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003934
VERSION     KCXD01003934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:19061:17390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..492
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62416.1"
                     /translation="CSRGSNYEDAYDYFSAFDSW"
     D_segment       418..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          136 c          140 g          107 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacc ttcagcatct atgccatcaa ttgggtgcga caggcccctg
      241 gacaagggct tgagtggatg ggagggatca tccctcttgt tggtataaca aactacgtac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacaagcata gcctacatgg
      361 agctgagcgg cctaagatct gaggacacgg ccgtgtatta ctgttcgaga gggtcaaatt
      421 acgaggatgc ttacgattac ttttctgcct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003935             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14980:6445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003935
VERSION     KCXD01003935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14980:6445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62417.1"
                     /translation="CATSSSGSWLYWYFDVW"
     D_segment       425..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          142 c          138 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt cagcgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgagatgat
      301 tgacgcagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggtc ctgagcagcc tgagatctga ggacacggcc gtctattact gtgcgacatc
      421 atccagcggc agttggctat actggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01003936             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15745:17547
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003936
VERSION     KCXD01003936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15745:17547"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..510
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62418.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          113 c          159 g          126 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgctgc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cagcttcagt ggctttggca
      241 tacactgggt ccgccaggct cctgggaagg ggctggagtg ggtgtcactt atatcgtatg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccttg tccagagaca
      361 attccaagaa catggtatat cttcacatga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgc gagagttagt gggcatacag aggggacagt tgaaaacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003937             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:28109:12620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003937
VERSION     KCXD01003937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:28109:12620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..461
     V_segment       95..386
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62419.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       400..406
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..461
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT          113 a          125 c          134 g           91 t
ORIGIN      
        1 acatggggac agaagcccca gagcacagca cctcaccatg gactggacct ggaggatcct
       61 cctcttggtg gcagcagcta caggcgccca ctctgaggtc caggtggtgc agtctggggc
      121 tgaggtgaag aagcctgggg cctcagtgaa ggtctcctgc aaggtttccg gatacatctt
      181 aaccgaatta tccatacact gggtgcgaca ggcccctgga aaagggcttg agtggatggg
      241 aagtgttgat cctcaatatg gtgaaatgat agacgcagag aaattccagg gcagagtcac
      301 catgaccgag gacacgtcta cagacacagc ctacatggag ctgagcagtc tgagatctga
      361 ggacacggcc gtgtattact gtgcgacatc atccagcggc acctggctat actggtactt
      421 cgatatctgg ggccctggca ccccaatcac catctcctca gcc
//
LOCUS       KCXD01003938             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13749:13288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003938
VERSION     KCXD01003938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13749:13288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62420.1"
                     /translation="CSRGLGSSAHFGLDSW"
     D_segment       416..423
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           99 a          138 c          143 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggctggga gggatcgtcc ctcttgttgg aacaacaaac tccgcacaga
      301 agttccagga cagagtcacg attaccgcgg acacgtccac aagcacagtc tacatggagc
      361 tgagcagcct gagatctgac gacacggccg tgtattactg ttcgagaggc ctgggtagca
      421 gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01003939             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:6977:7964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003939
VERSION     KCXD01003939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:6977:7964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62421.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          120 a          141 c          144 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctgggg cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 atacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 cttcatggag ttgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaacct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01003940             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:12501:7802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003940
VERSION     KCXD01003940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:12501:7802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62422.1"
                     /translation="CARYDDDDYGYYYLDYW"
     D_segment       406..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           92 a          135 c          132 g          112 t
ORIGIN      
        1 acagggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 ggctccatca gcaatagtta ctggttctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatctatgg ttctactggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcagca tttcaacaga cacgtccgag gaccagttct ccctgaagtt gagttctgtg
      361 accgccacgg acaccgccgt gtattattgt gcgagatatg acgacgatga ttacggttac
      421 tattaccttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003941             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6283:17904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003941
VERSION     KCXD01003941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6283:17904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62423.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          108 a          140 c          138 g           99 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtctccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgacg gtttcctgcg
      181 gggcctctgg attcaccttc gacacccatg gaatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttattgg tatcacaaac tacgcaaaga
      301 actctcaggg cagagtcaca ataaccgcga acacgtccac aaacacggcc tacatggagc
      361 tgagcagcct gagatctgag gacacggcca tctattattg tgcgagagaa tactgtactt
      421 ctagtagttg cgccgggttc cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01003942             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4764:12973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003942
VERSION     KCXD01003942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4764:12973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..395
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62424.1"
                     /translation="CVTGRRQLDLDYW"
     D_segment       404..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           89 a          134 c          131 g          106 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctacagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg ctgtctctgg
      181 tgactctatc agcagttact tcttgacctg gatccgccag gccccaggga agggactgga
      241 gtggattggg tttctctatg gaagtgatag tacctccaat tacaacccct ccctcaagag
      301 tcgagtcgcc ctgtcagtag acacgtccaa gaaccagttc tccctgaacc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattattg tgtgaccggg agacggcagc tggatcttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003943             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14027:11639
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003943
VERSION     KCXD01003943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14027:11639"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62425.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          110 c          154 g          123 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttattgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatgttca gtaactatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatatcgta
      301 tgatgtaact gtgaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aatacggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01003944             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:9793:15724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003944
VERSION     KCXD01003944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:9793:15724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62426.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       399..414
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           90 a          138 c          134 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctc tcacctgcgc tgtctctggt
      181 gactccatca gcagtaccta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tggtggtggg aacaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga cacgtccagg aaccagttct ccctgcagct gagttatgta
      361 agtgccgcgg acacggccat gtattactgt gcgagaacta gcggtggctg gtccccctac
      421 tttgactatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003945             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21754:14112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003945
VERSION     KCXD01003945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21754:14112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62427.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       411..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          139 c          145 g          106 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttg agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tctattattg tgcgagaggc tactgtactg
      421 gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003946             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:27311:8287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003946
VERSION     KCXD01003946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:27311:8287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..445
     V_segment       91..384
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62428.1"
                     /translation="CARSWFGYGLDSW"
     D_segment       387..392
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..445
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           82 a          132 c          138 g           95 t
ORIGIN      
        1 acatggggag tcatggacat cctgtgcaag aacatgaagc acctgtggtt cttcctcctc
       61 ctggtggcag ctcccagatg ggccctgtcc caggtgcagc tgcaggagtc gggcccagga
      121 ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtgg ctccctcagt
      181 ggttacaact ggaactgggt ccgccagccc ccagggaagg gactggagtg gatggggggt
      241 atcggtggtg gtagtgggag caccgagtac aacccctccc tcaaaagtcg agtcaccatt
      301 tcaagagaca cgtccaggaa ccacttctcc ctgaggctga cctctgtgac cgccgcagac
      361 acggccgtgt attactgtgc gagatcctgg tttggctacg gtttggattc ctggggccaa
      421 ggggtcgtcg tcaccgtctc gtcagcc
//
LOCUS       KCXD01003947             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14146:17209
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003947
VERSION     KCXD01003947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14146:17209"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62429.1"
                     /translation="CAIWSWRAATLRGALDYW"
     D_segment       410..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           89 a          137 c          145 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggaccagg actggtgaag ccttcggaga ccctgtcact cacctgcgct gtctctggtg
      181 gctccctcag cagtcactgg tggagctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatggt aatagtgggg gcaccaatta taacccctcc ctcaagagtc
      301 gagtcaccat ttcaagagac gcgtccaaga accacttctc cctgaaggtg acctctgtga
      361 ccgccgcgga cacggccgtg tatttctgtg cgatatggtc ctggagggca gcaactttgc
      421 gtggggccct tgattactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003948             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:15456:13093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003948
VERSION     KCXD01003948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:15456:13093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..298
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..298
     V_segment       8..236
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62430.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       237..243
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..298
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        299..>300
                     /gene="IGHG"
BASE COUNT           76 a           71 c           83 g           70 t
ORIGIN      
        1 acatggggta cagcctctgg attcaccttc agtagctatg gcttgcactg ggtccgccag
       61 gctccaggga aggggctgga gtgggtgaca gttatatcgt ctgatgaaag taggaaatac
      121 tacgcagact ctctgaagga ccgattcacc atttccagag acaattccaa gaacacgcta
      181 tatcttcaaa tgaacaacct gaaattggag gacacggccg tatattactg tgcgagggat
      241 gataatgggg tgcttatcga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003949             382 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14688:20538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003949
VERSION     KCXD01003949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 382)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 382)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14688:20538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..380
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..380
     V_segment       20..313
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>349
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62431.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       314..318
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       334..380
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        381..>382
                     /gene="IGHG"
BASE COUNT           80 a           95 c          127 g           80 t
ORIGIN      
        1 acatgggggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
       61 tggggggtcc ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat
      121 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      181 tggggagagc acatactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa
      241 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      301 ttactgtgcg agagtggtgg gtggtgccgc aggatacttc gacttctggg gccagggcgc
      361 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003950             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9125:20473
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003950
VERSION     KCXD01003950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9125:20473"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62432.1"
                     /translation="CAREYCTSDACAGFFDYW"
     D_segment       419..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          118 a          136 c          139 g          103 t
ORIGIN      
        1 acatggggga tcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagcta caggtgtcca
      121 gtcccaggtc cacttggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtttcctgc aaggcttctg gattcaccct cgacaactat ggaatcaact gggtgcgaca
      241 ggcccctgga caagggctgg agtggatggg agtgatcatc ccccttgtcg gtatagtgaa
      301 ctacgtagag aacctccagg gcagagccac gataaccgcg gacacgtcaa caaacacagt
      361 ctacatggaa ttgaacagcc tgagatctga cgacacggcc atctattatt gtgcgagaga
      421 atactgtact tctgatgctt gcgccggatt ctttgactac tggggccagg gagtcccggt
      481 caccgtctct tcagcc
//
LOCUS       KCXD01003951             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19174:13690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003951
VERSION     KCXD01003951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19174:13690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..480
     V_segment       114..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62433.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       419..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          137 c          135 g           99 t
ORIGIN      
        1 acatggggac agccacatcc ctcccctaca gaagccccag agcacagcac ctcaccatgg
       61 actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc tctgaggtcc
      121 agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag gtctcctgcg
      181 aggtttccgg atataccttc accgaactgt ccattcattg ggtgcgacag gcccctggaa
      241 aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata aacgcagaaa
      301 aattccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc tacatggacc
      361 tgatcagtct gagatctgaa gacacggtcg tgtattactg tgcgacatca cccagcggca
      421 cctggctata ttggtacttc gatttctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01003952             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7794:12905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003952
VERSION     KCXD01003952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7794:12905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62434.1"
                     /translation="CATGRFGSSVWSTLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          143 c          150 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgagatg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctggaaatg gtgaaataat
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgacatctga ggacacggcc gtgtattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccaccct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003953             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7527:19506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003953
VERSION     KCXD01003953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7527:19506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62435.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          141 c          138 g          106 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccgcctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg cggggcttct ggattcaccc tcgacaccta tggtatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtggtcat cccccttatt ggtatcataa
      301 actacgcaaa gaactctcag ggcagactca caataaccgc gaacacgtcc acaaatacag
      361 cctatttgga actgagcagt ctgagatctg aggacacggc catctattac tgtgcgagag
      421 aatactgtac ttctagttct tgcgccgggt tccttgacta ctggggccag ggagccctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003954             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22652:3822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003954
VERSION     KCXD01003954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22652:3822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62436.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       450..458
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          114 c          156 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcgatg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ggttatatcg
      301 tttgatgata gtaagaaata ctactcagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga tgcttacggt agtggctggg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003955             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17975:11946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003955
VERSION     KCXD01003955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17975:11946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62437.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       411..417
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..468
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           95 a          141 c          129 g          105 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ttgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtttctggtg
      181 actccatcac cagtgcctac tactggagct ggatccgcca acccccagga agggggcttg
      241 agtggattgg gtgtatcggt ggtagtagtg gtaacaccta ctacaactcc tccctcaaga
      301 gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaag ctgacctctg
      361 tgaccgtcgc ggacacggcc gcctattact gtgcgagaaa acttccggga ctacaactaa
      421 ccggtttcga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01003956             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13533:19441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003956
VERSION     KCXD01003956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13533:19441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..436
     V_segment       76..369
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62438.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       370..374
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..436
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           89 a          105 c          141 g          103 t
ORIGIN      
        1 acatgggcag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
       61 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      121 gggtccctga gactctcctg cgcagcctct ggattcaact tcaattacta ctacatgaac
      181 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattga cagtggtggg
      241 gatagcacat actatgcgga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      301 aagaacacac tgtatcttca attggacagc ctgagagctg aggacacggc tgtctattac
      361 tgtgcgagag tggtgggtgg tgccgcagga tacttcgact tctggggcca gggcgccctg
      421 gtcaccgtct cctcagcc
//
LOCUS       KCXD01003957             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16730:18008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003957
VERSION     KCXD01003957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16730:18008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62439.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          111 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctttg
      241 gcatgcattg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg cgcgagagac gattttggca gcggcttagg gtactggggc cagggagccc
      481 tggtgaccgt ctcctcagcc
//
LOCUS       KCXD01003958             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:21591:15891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003958
VERSION     KCXD01003958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:21591:15891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62440.1"
                     /translation="CARWSAANFDYW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           91 a          133 c          138 g           98 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga cctcctgggc aagaacatga ggcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 gggctccatc agcagtggtt atggctggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatg gggtgtatct atgatagtag tggaaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga agctgaggtc
      361 tatgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003959             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9381:10626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003959
VERSION     KCXD01003959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9381:10626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..485
     V_segment       104..397
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62441.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       402..406
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           98 a          145 c          135 g          109 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacaga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcacttcct actggagctg gatccgccag gccccaggga agggactgga
      241 gtggattgga tatatctatg ctgatagtgg gaccaccagc tacaacccgt ccctcaagag
      301 tcgagtcacc atttcaatag acacgtccaa gaatctgtac tccctgaaac tgagctctgt
      361 gaccgccgcg gacacggcct tttattactg tgcgagacgt cctactcgca cgcgggttct
      421 atatgaggcg acaggggaag actttgactc ctggggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01003960             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14526:9894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003960
VERSION     KCXD01003960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14526:9894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..499
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62442.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       454..461
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..499
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>505
                     /gene="IGHG"
BASE COUNT          108 a          123 c          158 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacctact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgacg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatat ttcgacttct ggggccaggg
      481 cgcactggtc accgtctcca cagcc
//
LOCUS       KCXD01003961             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10150:2540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003961
VERSION     KCXD01003961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10150:2540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62443.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          123 c          147 g          130 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc ttctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccgagaa ctccttgttc cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003962             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:7698:4272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003962
VERSION     KCXD01003962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:7698:4272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..459
     V_segment       84..383
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62444.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       388..404
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..459
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           99 a          139 c          118 g          105 t
ORIGIN      
        1 acatgggggg actcctgtgc cccaccatgg acacgctttg ctacacactc ctgctactga
       61 ccgtcccgtc ctgggtcttg tcccaggtga ccttgaagga gtctggtcct gcgctggtga
      121 aacccacaca gaccctcacg ctgacctgca ccttctctgg gttctcaatc agtacttctg
      181 caacaggtgt gggctggatc cgtcagcccc cagggaaggc cctggaatgg cttgcaagca
      241 tttattggaa tgatactaaa ttcttcagca cttcgctgaa gagcagactc accgtctcca
      301 aggacacctc caaaacccag gtggttttaa caatagccaa catggaccct gtggacacag
      361 ccacatatta ctgtgcacgg atacagggtg gtagttacta ctacggtggg ggatacttcg
      421 agttctgggg ccagggcgcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003963             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11904:16484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003963
VERSION     KCXD01003963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11904:16484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..520
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62445.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       446..465
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..520
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          113 a          129 c          154 g          126 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggttcc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttacgacatg
      241 acctgggtcc gccaggctcc gggaaagggg ctggaatggg tctcatatat tagttacact
      301 ggtaaaacca tatactactc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaact ctctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgttcta gagcggctta cgaacatgat gacggttact attacgtcgg caggtttttt
      481 gactgctggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003964             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20712:4285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003964
VERSION     KCXD01003964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20712:4285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..472
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62446.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       411..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           95 a          144 c          124 g          111 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacgtg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctttg gagaccctgt ccctcacctg cgctgtctct
      181 ggtgtctcca tcaacgatta ccattggagc tggatccgcc agccccctgg gaagggactg
      241 gagtggattg gacatatctc tcatagtcgt ggaagcaccg actacaaccc ctccctcaag
      301 agtcgcgtca ccatttcaac agacacgtcc aagaaccagt tctccctgaa gctgagctct
      361 atgacccccg cggacacggc cgtctattac tgtgcgagag atcaggattc ttacgtttac
      421 tatcgcttct ttgacttctg gggccaggga gtcctggtcg ccgtctcctc agcc
//
LOCUS       KCXD01003965             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14845:2710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003965
VERSION     KCXD01003965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14845:2710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..445
     V_segment       76..367
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62447.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       386..395
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..445
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT           88 a          136 c          129 g           94 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggctcttcc tcctgctggt ggcagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagccctca
      121 gagaccctgt ccctcacctg cgctgtctct ggtgcctcca tcggtagtta ctggtggacc
      181 tggatccgcc agcccccagg gaagggactg gagtggattg gggagatcaa tggaaatagt
      241 ggtagtacct actatagccc ctccctcaag agtcgagtca ccatttcaaa agacgcgtcc
      301 aagaaccacc tctccctgaa gctgaactct gtgaccaccg cggacacggc cgtgtatttc
      361 tgtgcgaacg tcttaggccc ctggggcagc tggtcacact actttgacta ctggggccag
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003966             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10413:13364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003966
VERSION     KCXD01003966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10413:13364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..469
     V_segment       118..407
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62448.1"
                     /translation="CAGGAYANLDYW"
     D_segment       418..422
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          102 a          118 c          144 g          107 t
ORIGIN      
        1 acatggggga agtccacagt gttccattcg gtgatcagca ctgaacacag aggactcacc
       61 atggagtctg ggctgagctg ggttttcctt gttgctattt taagaggtgt ccagtgtgag
      121 gtgcaaatgg tggagtctgg gggcggcttg gcaaagcctg gggggtccct gagactctcc
      181 tgtgcagcct ctggattcac cttcagtaga tactggatga actgggtccg ccaggctcca
      241 ggaaaggggc tggagtgggt ctcagctctt aattatgatg gggatagtac atactacgca
      301 gactccgtga agggccgatt caccatctcc agagacaact caaagaacac gctctccctg
      361 caaatgcaca gcctgagaga agatgacacg gccgtttatt tctgtgcggg cggggcgtac
      421 gctaacctcg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01003967             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21394:2650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003967
VERSION     KCXD01003967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21394:2650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..484
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62449.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       409..420
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          109 a          137 c          136 g          104 t
ORIGIN      
        1 acatggggga accacatccc tcctctaaag aagcccctgg gagcacagct catcaccatg
       61 gactggacct ggaggctcct ctttgtggtg gcagcagctg caggtgtcca gtcccaggtc
      121 cgcctggtgc agtccgggac tgaggtgaag aagcctgggg cctcagtgaa gatttcctgc
      181 ggggcttctg gattcaccct cgacacctat ggtatcaact gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agtgatcatc ccccttattg gtatcatcaa ctacgcagag
      301 aactctcagg gcagactcac aataaccgcg aacacgtcca caaatacagc ctatatggaa
      361 ctgagcagtc tgagatctga ggacacggcc atctattact gtgcgagaga atactgtact
      421 tctagtactt gcgccgggtt ccttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01003968             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20972:7272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003968
VERSION     KCXD01003968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20972:7272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62450.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       412..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          105 a          150 c          132 g           94 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcccgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgct cccgcatatg gtgaaatgac
      301 attccagggc agagtcttca tgaccgagga cacgtctaca gacacagcct acatggagct
      361 gaccagcctg acatctgacg acgcggccgt ctattactgt gcggttggcc ctagcggcac
      421 ttggaaccac tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01003969             383 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5096:4609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003969
VERSION     KCXD01003969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 383)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 383)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5096:4609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    27..381
                     /note="immunoglobulin heavy chain variable region"
     V_region        27..381
     V_segment       27..306
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <300..>350
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62451.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       324..332
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       333..381
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        382..>383
                     /gene="IGHG"
BASE COUNT           85 a          105 c          115 g           78 t
ORIGIN      
        1 acatgggaac tacaggcgcc cactctgagg tccttctggt gcagtctggg gctgaggtga
       61 tgcagcctgg ggcctcagtg aaggtctcct gcaaggtttc cggaaacacc ttcaccgaat
      121 tgtccatgca ctgggtgcga caggcccctg gaaaagggct tgagtgggtg ggaagtgttg
      181 atcctgcata tggtgaaatg acgttccagg gtagagtcac catgaccgag gacacgccta
      241 cagacacagc ctacatggaa ctgagcagcc tgacatctga ggacacggcc gtgtattact
      301 gcgcgattgg ccctagtggc agatggaacg actggtcctt cgacatctgg ggacctggca
      361 ccccaatcac catctcctca gcc
//
LOCUS       KCXD01003970             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16065:19382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003970
VERSION     KCXD01003970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16065:19382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62452.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       452..460
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          117 a          117 c          149 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttatt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatgaaa ttaagaaata ctacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgaggga ggagagattt ggctacagtt ttgacttctg gggccaggga
      481 atcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003971             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12070:18985
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003971
VERSION     KCXD01003971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12070:18985"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..450
     V_segment       93..385
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62453.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       392..401
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           81 a          138 c          134 g           99 t
ORIGIN      
        1 acatggggag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg ttcttcctcc
       61 tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt ggctccatca
      181 gcggttactg gtggggctgg atccgccagt ccccaggaaa ggggctggag tggattgggt
      241 ttttcggtgg ttatggtggg agcacctact acaacccctc cctccagagt cgagtcacca
      301 tttcagccga cacgtccaaa caccagttct ccctgatact gacctctgtg accgccgcgg
      361 acacggccct ctactattgt gcgaggggga atatagcagc gactggcatt gactactggg
      421 gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01003972             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16394:15771
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003972
VERSION     KCXD01003972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16394:15771"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62454.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          144 c          149 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacaccgt cagcgaattg tccatgcact gggtacgaca
      241 ggcccctggg aaagggcttg agtggatggg agttgttgat cctgtcaatg gtgaagaaat
      301 acacgcagag aagttccagg gcagagtcac catgaccgag gacacgtgga cagacacagc
      361 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcggt agcagcggct ggtccaacct cttcaccggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003973             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5317:14398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003973
VERSION     KCXD01003973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5317:14398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62455.1"
                     /translation="CAIGPSGRWNAWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          144 c          137 g           93 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagcttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa gaggccttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgta tattactgtg cgatcggccc tagcggcagg
      421 tggaacgcct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01003974             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2801:12765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003974
VERSION     KCXD01003974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2801:12765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62456.1"
                     /translation="CAGGSRRQPENW"
     D_segment       404..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           82 a          132 c          141 g          100 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctatgcaa gagcatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagcc cccagggaag gggctggagt
      241 ggattgggta tatcggtggt actagtggga gtacctacta caatccctcc ctcgagagtc
      301 gagtcaccat ttcaacagac acgtccaaga atctcttctc cctgaagatg agttctttaa
      361 ccgccgcgga cacggccatg tatttctgtg cgggcggaag tcggcggcag ccggagaact
      421 ggggccaggg agtcctggtc accgtctctt cagcc
//
LOCUS       KCXD01003975             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:15637:14225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003975
VERSION     KCXD01003975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:15637:14225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62457.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          139 c          136 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctaaatatgg tgaaatgata
      301 gacgcagaga aagtccaagg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatcg
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcgtcag cc
//
LOCUS       KCXD01003976             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:22979:14564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003976
VERSION     KCXD01003976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:22979:14564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62458.1"
                     /translation="CARDESALSYPFDYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           87 a          143 c          132 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc agtaactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggacgt atctatggtg ttcgtgggac taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgcccaagaa ccagttttcc ctgaagctga cctctgtgac
      361 cgtcgcggac acggccgtgt attactgtgc gcgagacgag agcgccttgt cttacccctt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003977             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10286:17559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003977
VERSION     KCXD01003977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10286:17559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62459.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          151 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaac aaagaaatac tacgcagact ctctgaagga ccgcttcatc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaataacct gaaattggat gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggtgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003978             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10591:7012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003978
VERSION     KCXD01003978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10591:7012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62460.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          124 a          140 c          136 g           95 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaggtggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      301 atagacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag tctgagatct gaggacacgg ccgtgtatta ctgtgcgaca
      421 tcatccagcg gcacctggct atactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01003979             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24749:11530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003979
VERSION     KCXD01003979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24749:11530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62461.1"
                     /translation="CATGFGGSWTRFDYW"
     D_segment       409..414
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           88 a          133 c          134 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagt agtaactact ggagttggat ccgccaggcc ccagggaagg gactggaatg
      241 gattggatat atctttggta gtggctgtga caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaacaa tcagctctcc ctggagctga gctctgtgac
      361 cgccgcggac acggcccttt attattgtgc gaccgggttt ggtggcagtt ggaccagatt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01003980             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:16969:13272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003980
VERSION     KCXD01003980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:16969:13272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62462.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       443..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          117 c          155 g          115 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaagtgcagc tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt ggctctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcggtt atagccaatg
      301 atggaactaa gaaatactac gcagactctg tgaaggaccg attcagcatt tccagagaca
      361 actccaagaa catactgtat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 actactgtgc gacagatgcg tttggtagcg ggattgacta ctggggccgg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01003981             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22618:17208
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003981
VERSION     KCXD01003981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22618:17208"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..401
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62463.1"
                     /translation="CARMWYWPTPDVW"
     D_segment       407..413
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..462
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           87 a          132 c          141 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg taagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc agcagtggtg aggccttcgg agaccctgtc cctcacctgc gttgtctctg
      181 gtggctccat cagcggtggt tatggctgga actggatccg ccaggcccca gggaagggac
      241 tggagtggat tgggagtctc tttggcagta gtggaagaac ctactacaat ccgtccctca
      301 agagtcgagt cgctatttca aaagacacgt ccaagaacca gttctccctg atcctgaggt
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag aatgtggtac tggccgaccc
      421 ccgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01003982             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17343:15221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003982
VERSION     KCXD01003982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17343:15221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62464.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           93 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac atcttaaccg aattatccat acactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaagtg ttgatcctca atatggtgaa atgatagacg
      301 cagagaaagt ccaaggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagtctgaga tctgaggaca cggccgtgta ttactgtgcg acatcgtcca
      421 gcggcacctg gctatactgg tacttcgata tctggggccc tggcacccca atcaccatct
      481 cgtcagcc
//
LOCUS       KCXD01003983             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11568:13860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003983
VERSION     KCXD01003983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11568:13860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62465.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       449..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          114 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcgt
      301 ttgatgatag taagaaatac tacgtagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcttacggta gtggctggga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003984             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:23426:13856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003984
VERSION     KCXD01003984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:23426:13856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62466.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       420..428
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          118 a          142 c          133 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc cccccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggcc gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg acacacctac accgaagtat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctatatatgg tgaaatacta
      301 aacacagaca agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc
      361 tacatggagt tgagcagcct gagatctgag gacacggccg tatattactg tgtggcggct
      421 gatagtggtt acccttttta ctacttcgat atctggggcc ctggcacccc aatcagcatc
      481 tcctcagcc
//
LOCUS       KCXD01003985             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6048:7989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003985
VERSION     KCXD01003985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6048:7989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62467.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       449..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          154 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcgt
      301 ttgatgatag taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcttacggta gtggctggga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003986             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21347:12508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003986
VERSION     KCXD01003986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21347:12508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62468.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       435..447
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          112 a          108 c          154 g          117 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggctgggtt cagccggggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcaac ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgatatcg tttgatgaaa
      301 gtaagaaata ctatgcagac tctgtgaagg accgattcac cgtctccaga gacaattcca
      361 agaacatggt atatcttcaa atgaacaact tgaaattgga ggacacggcc gtgtattact
      421 gtgtgagaga ctcttatgga agtggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01003987             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:27600:12870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003987
VERSION     KCXD01003987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:27600:12870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62469.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       443..450
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          112 a          117 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattatg
      241 gcatgcactg ggtccgccag gctccgggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaat taagaagtac cacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa caacatacta tatcttcaaa tgaacaacct gagattggac gacacggccg
      421 tgtattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg ggccaagggc
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01003988             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11220:15259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003988
VERSION     KCXD01003988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11220:15259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62470.1"
                     /translation="CTRHVGAYIAPTGLRYFDYW"
     D_segment       428..435
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           96 a          137 c          139 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag gacatgaagc gcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctaatta
      181 ctccaccagc aaaggttact actggggctg gatccgtcag tccccaggga agggactgga
      241 gtatattggg tatatcagtg gtagtagtgg gagcacctac tacaagccct ccctcatgag
      301 tcgagtcacc atctcaaaag acacgtccag gaagcagttc tccctgaagc tgagctctgt
      361 gacggccgcg gacacggccg tgtattactg tactagacat gtgggggcgt atattgcacc
      421 gactggtcta cggtactttg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01003989             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22933:16042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003989
VERSION     KCXD01003989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22933:16042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62471.1"
                     /translation="CAKGETATPYYGLDSW"
     D_segment       440..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          111 a          129 c          153 g          112 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agatgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatacactgg gtccgccagg ctccagggaa gggactggag tgggtctcag ctattagcac
      301 tggtggtagg acattctacg cagactccgt gaagggccga ttcaccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagcctgaga gctgaggaca cggccatgta
      421 ttactgtgcg aaaggggaaa cagctacacc ttactacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01003990             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12182:10959
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003990
VERSION     KCXD01003990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12182:10959"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..513
     V_segment       138..429
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62472.1"
                     /translation="CVRERFGGIGVIIFNWIDVW"
     D_segment       465..471
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          110 a          122 c          161 g          122 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tatttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcacctgg tgcagtctgg gggcggcctg acaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ccggattcac cttcagtgac tactatatgg
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcacgaatc ggtcatgatg
      301 gtggtttcac atggtacgca gactccgtga agggcagatt taccatttcc agagagagtg
      361 ccaagaacac actgtttctt caaatggaca gcctgagaag tgacgacaca gccgtatatt
      421 actgtgtgag agagcggttt gggggaattg gggtaataat cttcaactgg atcgatgtct
      481 ggggcccggg agtcctggtc accgtcccct cagcc
//
LOCUS       KCXD01003991             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5908:8594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003991
VERSION     KCXD01003991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5908:8594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62473.1"
                     /translation="CATGFGGSWTRFDYW"
     D_segment       411..416
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           90 a          137 c          133 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 ggctctatca gtagtaacta ctggagttgg atccgccagg ccccagggaa gggactggaa
      241 tggattggat atatctttgg tagtggcagt gacaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaac aaccagctct ccctggagct gacctctgtg
      361 accgccgcgg acacggccct gtattactgt gcgaccgggt ttggtggcag ttggaccaga
      421 tttgactact ggggccaggg actcctggtc accgtctcct cagcc
//
LOCUS       KCXD01003992             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8171:14294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003992
VERSION     KCXD01003992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8171:14294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62474.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          136 c          126 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactactgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatttctgg tgcttatggg agcaccagtt acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcccag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggagcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01003993             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7577:9231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003993
VERSION     KCXD01003993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7577:9231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62475.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          114 c          147 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgtgag gtccagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct cagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccctctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01003994             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:7624:17123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003994
VERSION     KCXD01003994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:7624:17123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62476.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       410..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          130 c          136 g          107 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagcctccgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctctat cagcagtagt tactgcagct ggatccgcca gaccccaggg aagggactgg
      241 agtggattgg gtatatttat gggagtgata gtagtaccaa atacaacccc tccttcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccggtg ttccctgaag ctgaactctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc gggtatagaa gtggttgcct
      421 acagcattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01003995             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11341:20251
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003995
VERSION     KCXD01003995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11341:20251"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62477.1"
                     /translation="CARDGRGSGTDVW"
     D_segment       444..448
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          111 c          160 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccgtca gtagttttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatggaaat acgagattct acgcagactc tgtgaaggac cgattcacca tctccagcga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgagagatg ggcggggttc aggcacggat gtctggggtc ggggagttct
      481 agtcaccgtc tcctcagcc
//
LOCUS       KCXD01003996             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:5970:6119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003996
VERSION     KCXD01003996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:5970:6119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62478.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           91 a          131 c          137 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgatg tctctggggg
      181 ctccatcagc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtatctacg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaaga tgaggtctat
      361 gaccgccgcg gacgcggccg tgtattattg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01003997             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19944:16079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003997
VERSION     KCXD01003997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19944:16079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..435
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62479.1"
                     /translation="CTRIGVGSLATTGQYFDYW"
     D_segment       459..465
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          111 a          124 c          154 g          127 t
ORIGIN      
        1 acatgggggc agctctgaga caggagcctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttgg tgattatggc
      241 atgcactgga tccgccaggc tccgggaaag ggactggagt gggtctcatc cattagaaac
      301 actggtaaaa ctatatatta tgctgactcc gtgaagggcc gattcaccat ttccagagac
      361 aacgccaaga actcgttgtc tctgcaaatg gacagcctga gagccgagga cacggccgtg
      421 tattattgta ctagaattgg cgtcggatct ctagcaacga ctggtcagta ctttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01003998             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:4560:13936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003998
VERSION     KCXD01003998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:4560:13936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62480.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          133 c          137 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatatttg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01003999             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14066:16342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01003999
VERSION     KCXD01003999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14066:16342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62481.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       418..426
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          118 a          141 c          132 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatcccc cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggccga agtgaagaag cctggggcct cagtgagggt
      181 ctcctgcaag gtttccggac acacctacac cgaagtatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgctcct atatatggtg aaatactaaa
      301 cacagacaag ttccagggca gagtcaccat gaccgaggac acgtctgcag acacagccta
      361 catggagttg agcagcctga gatctgagga cacggccgta tattactgtg tggcggctga
      421 tagtggttac cctttttact acttcgatat ctggggccct ggcaccccaa tcagcatctc
      481 ctcagcc
//
LOCUS       KCXD01004000             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18612:9265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004000
VERSION     KCXD01004000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18612:9265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62482.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       443..455
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          121 c          153 g          124 t
ORIGIN      
        1 acatggggta ggagaggagc ccagccctgg gattcccagg tgttttcatt tgtgatcagc
       61 actgaataca gaagactcat catggagttt ggcctgagct gggttttcct tgctgctatt
      121 ttaaaaggtg tccagggtga ggtgcagctg gtggaatctg ggggcggctt ggcaaagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccctcagtaa ctactggatg
      241 tactgggttc gccaggcacc agggaagggg ctggagtgga tctcagctat taacagtgtt
      301 ggtgatacca catactatgc agactccgtg aagggcagat tcaccatctc cagagagaac
      361 gccaagaaca ctctgtatct tcaaatggac agcctgagag ctgaggacac ggctatctat
      421 tactgtgcga gagttccggg cctagtggta tttaccggtt cgcttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004001             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:18033:12500
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004001
VERSION     KCXD01004001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:18033:12500"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62483.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       445..451
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          118 c          153 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgctggaagt aagaaatact acgcagactc tttgaaagac cgattcacca tatccagaga
      361 cgactccagg aacatgctat atcttcaact gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctg ggggcttgac tactggggcc agggagtcct
      481 agtcaccgtc tcctcagcc
//
LOCUS       KCXD01004002             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10442:9719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004002
VERSION     KCXD01004002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10442:9719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62484.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          148 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtaattttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag tcacaaatac tacgccaact ctgtgaagag ccgattcgcc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004003             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14106:9368
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004003
VERSION     KCXD01004003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14106:9368"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62485.1"
                     /translation="CARKWAGYGLDSW"
     J_segment       410..458
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           95 a          132 c          132 g          101 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggagc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccctc agcggttact actggaattg gatccgccaa ccaccaggga aggggctgga
      241 gtggattggt tatatcgctg gtagtagtgg aagtaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccag gaaccagttc tccctgaaac tgacctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcaagaaaa tgggccggat acggtttgga
      421 ttcctggggc caaggggtcg tcgttacagt ctcctcagcc
//
LOCUS       KCXD01004004             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25031:13925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004004
VERSION     KCXD01004004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25031:13925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62486.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          118 a          118 c          144 g          128 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgtttctat
      121 attaaaaggt gtccagtgtg tggagcatct ggtggagtct gggggagact tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagtg cctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctagaatgg gtatcaggaa ttaacattgg
      301 cggtgaccca tactacccag actctgttaa gggtcgattc accatctcca gagacaatgc
      361 caagaactcc ttgtatcttc agatgaacaa tctgagagct gaggacactg ctgtgtatta
      421 ttgtgtgagg ggaatggata actaccacta cagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004005             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13063:9903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004005
VERSION     KCXD01004005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13063:9903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62487.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       440..444
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          113 c          152 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttatc tcatttgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt cacatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg gggacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004006             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24821:6315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004006
VERSION     KCXD01004006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24821:6315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62488.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          147 c          141 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaata
      301 cacgcagaca acttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01004007             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16301:21082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004007
VERSION     KCXD01004007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16301:21082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..397
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62489.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       404..415
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           94 a          135 c          129 g          103 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca aatgggtcct gtcccagcta caattgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc tgtcacctgc gctgtctctg
      181 gtggctctat cagcatttac tactggaatt ggatccgcca ggccccaggg aagggactgg
      241 actggattgg acatatctat ggtagcggtg atagcaccaa cttcaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtt ctccctgaac ctgaggtctg
      361 tgaccgccgc ggacacggcc gtatattact gtgcgagcgg tcggcggcag ctggactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004008             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14652:6364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004008
VERSION     KCXD01004008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14652:6364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62490.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          118 c          147 g          133 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttcgttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga atctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agttcctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtttcc ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 atgccaagaa ctccttgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtac aagggggata gataactacc actttagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004009             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19095:9833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004009
VERSION     KCXD01004009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19095:9833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..426
     V_segment       63..362
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <351..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62491.1"
                     /translation="CARRIRGGWPYFDFW"
     D_segment       372..376
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       384..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           93 a          129 c          110 g           96 t
ORIGIN      
        1 acatggggga cacgctttgc tccacgctcc tgctgctgac cgtcccgtcc tgggtcttgt
       61 cccaggtgac cttgaaggag tctggtcctg cgctggtgaa acccacacag accctcacgc
      121 tgacctgcgc cgtctctggg ttctcactca acaatattgg tatgggggtg ggctggatcc
      181 gtcagccctc aggaaagacc ctggagtggc ttgcacacat ttactgggat gataacaagc
      241 tctacagcac atctctaaag aacagactca ccatctccag ggacacctcc aaaaacctgg
      301 tacttctgac aatgaccaac atggaccctg cggacacagc cacatatttc tgtgcacgaa
      361 gaattagggg cggttggccg tattttgact tctggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01004010             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21065:12148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004010
VERSION     KCXD01004010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21065:12148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62492.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       406..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          134 c          130 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtggct tctggaactg gatccgccag accccaggga aggggctgga
      241 gtggattggg tacatttatg gtagtactgg gaacaccggc tataacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtcaaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgcgagatat ggagatgata gtgttcatta
      421 caactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004011             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22651:13142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004011
VERSION     KCXD01004011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22651:13142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..494
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62493.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          110 a          117 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctctg
      241 gcatgcactg ggtccgccag tctccaggga aggggctgga atgggtggcg gttatatcga
      301 atgatggaac taagaaatac tacgcggact ctgtgaagga ccgattcagc atttccagag
      361 acaactccaa gaacatgctg tatcttcaaa tgaacaacct gaaagtggag gacacggccg
      421 tctacttctg tgcgacagat gcgtttggta gcgggattga ctactggggc cggggagtcc
      481 tggtcaccgt ctccacagcc
//
LOCUS       KCXD01004012             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23258:12815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004012
VERSION     KCXD01004012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23258:12815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62494.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       406..412
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           91 a          144 c          131 g           97 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga ggcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctacagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtaact tctggagctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctatg gtagtactga tagcaccagc tacaacccct ccctcacgag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat gcgggaactg ggaccccctt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004013             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12092:8668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004013
VERSION     KCXD01004013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12092:8668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..436
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62495.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       379..386
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       391..436
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           77 a          135 c          131 g           95 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcgcctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacctg cgctgtctct ggtggctcct tcagcggtta ctcctggagc
      181 tggatccgcc agcccccagg caagggtctg gagtggattg gacatgtcag tggtagtagt
      241 gggagcaccg actacaaccc ctccctcaag agtcgagtca ccatttcaac agacacgtcc
      301 aagcgccagt tctccctgag gctgatttct gtgaccgccg cggacacggc cgtctatcat
      361 tgtgcgagag tccggggcgt gactatctat tactttgact actggggcca gggagccctg
      421 gtcaccgtcg cctcagcc
//
LOCUS       KCXD01004014             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19521:6867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004014
VERSION     KCXD01004014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19521:6867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62496.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          110 a          122 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccaat gtgaggtgaa actggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaggttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtgttaatac
      301 tggtggggaa agcccatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aatacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc ggcgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004015             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18303:9184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004015
VERSION     KCXD01004015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18303:9184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62497.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       443..457
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          111 a          122 c          155 g          119 t
ORIGIN      
        1 acatggggga ggagaggagc ccagccctgg gattcccagg tgttttcatt tgtgatcagc
       61 actgaacaca gaagactcat catggagttt ggcctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagggtga ggtgcagctg gtggagtctg ggggcggctt ggcaaagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccatcagtaa ctactggatg
      241 tactgggttc gccaggcacc agggaagggg ctggagtgga tctcagccat taatagtgct
      301 gaaagtacca catactatgc agacgccgtg aagggcagat tcaccatctc cagagacaac
      361 gccaagaaca cactgtatct tcaaatggac agcctgagag ctgaggacac ggctgtctat
      421 tactgtgcga gagtaccggg cctagtggtg tttactggtt cccttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004016             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14979:12117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004016
VERSION     KCXD01004016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14979:12117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62498.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          120 a          140 c          139 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgtcagg cttctggata ttccctcact cactacttca tgcactgggt gagacaggcc
      241 cctggacagg gccttgagtg gataggactg atcacccctc acaatgatca taaagtctac
      301 gcacagaact tccagggcag agtcaccata actacggaca cgtccacgag cacagtgtcc
      361 atggagctga gcagcctgag atccgaagac acagccgtat actactgtgc gagagggggg
      421 gacatagaat attgtactgg tagtggttgt ggggagcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004017             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17171:6139
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004017
VERSION     KCXD01004017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17171:6139"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62499.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          136 c          128 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga caggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgtcagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtt cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004018             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17318:8740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004018
VERSION     KCXD01004018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17318:8740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..429
     V_segment       75..368
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62500.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       374..380
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       386..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           91 a          101 c          131 g          108 t
ORIGIN      
        1 acatgggggg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
       61 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      121 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct ggcatgcact
      181 gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg tatgatgaga
      241 ctaagaaata ctacgcagac tctgtgaagg accgattcag catctccaga gacaactcca
      301 agaatatgct atatcttcaa ctgaacaacc tgaaattgga ggacgcggcc gtgtattact
      361 gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01004019             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:12497:15262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004019
VERSION     KCXD01004019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:12497:15262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62501.1"
                     /translation="CASNSITSGPDYW"
     D_segment       399..405
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          141 c          128 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag gcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cgcctgcagc tgcaggcggc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgg
      181 ctctatcagc ggtaactact ggagctggat ccgccgggcc ccagggaagg gactggagtg
      241 gattggatat atctacggta gtgattttac caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagcagata cgtccaagaa ccagctctcc ctgaacctgg cctctgtgac
      361 caccgcggac acggccgtct atttctgtgc cagtaatagt ataacatctg gtccagatta
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004020             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12069:5032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004020
VERSION     KCXD01004020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12069:5032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62502.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           87 a          141 c          132 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagttggat ccgccagccc ccagggaagg gactggagtg
      241 gattggtcgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgcagctga attatgtaac
      361 cgccgcggac acggccgtgt attactgtgc cagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004021             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11869:21646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004021
VERSION     KCXD01004021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11869:21646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62503.1"
                     /translation="CASGPTTIFGMLVTGLDFW"
     D_segment       426..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          143 c          135 g          104 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc agctggtgca gtctgggtct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattct ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gttgttgatc ctttggataa tgaaataata
      301 tacgcagaca acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct gacctctgac gacacggcca tctattactg tgcgagtggg
      421 cctactacaa tttttggaat gcttgttacg gggcttgact tctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004022             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6269:4474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004022
VERSION     KCXD01004022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6269:4474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62504.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT          118 a          143 c          130 g           98 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccga ctacaccttc gccgaattac ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggttttgcta gtatatatgg tgaaataata
      301 catacagaga gattccaggg cagagtcacc atgacagcgg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc gatcaccatc
      481 tcctccgcc
//
LOCUS       KCXD01004023             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19379:3620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004023
VERSION     KCXD01004023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19379:3620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..484
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62505.1"
                     /translation="CARADYDDDYGYHLGYNWFDVW"
     D_segment       401..422
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..484
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          135 c          137 g          114 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgcg agaacatgaa gtatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gttgcaggag
      121 tcgggcccag gactgatgaa gccttcagag accctgtccc tcagctgcgc tgtctctggt
      181 ggctccataa gtggtaactg gtggagctgg atccgccagc ccccagggaa gggactggac
      241 tggattggac gtatctctgg tactagtggg gacaccaatt acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccacttct ccctgaagct gaactctgtg
      361 accgccgcgg acgcggccgt gtattattgt gcaagagcgg attacgatga tgattacggt
      421 tatcatttag gatacaactg gttcgatgtc tggggcccgg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01004024             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20117:11608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004024
VERSION     KCXD01004024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20117:11608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62506.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          138 c          150 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgagatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccaggaca gagtcaccat gaccgaggac acgtctatag acatagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004025             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21809:20252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004025
VERSION     KCXD01004025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21809:20252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..483
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62507.1"
                     /translation="CANGVAGLDFW"
     D_segment       429..434
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          101 a          117 c          159 g          108 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtgta tatactatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ctcaggaatt agtggtggtg
      301 gtaacacata ctacgcagac tccgtgaagg gccgattcac cgtctccaga gacgactcaa
      361 agagtacggt ctccctgcaa atgaacagcc tgagagctga ggacacggcc gtgtattact
      421 gtgcgaacgg ggtggcaggc ttagacttct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004026             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16046:16919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004026
VERSION     KCXD01004026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16046:16919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..494
     V_segment       116..407
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62508.1"
                     /translation="CATHGGYSDIWTSLYNGLDSW"
     D_segment       416..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          119 a          143 c          139 g           95 t
ORIGIN      
        1 acatggggaa acaaccacat ccctccccta cagaagcccc agagcacagc acctcaccat
       61 ggactggacc tggaggatcc tcctcttggt ggcagcagcc acaggcgccc actctgaggt
      121 ccacctggtg cagtctgggg ctgaagttaa gaggcctggg gcctcagtga tggtctcctg
      181 ccaggtttcc gggtacaccg tcaccgaaat atccatgcac tgggtgcgac aggcccctgg
      241 aaaagggctt gagtggatgg gaagtgttgc tcctgaaaaa aatgaattaa tacacgcaga
      301 caagttccag gacagagtca ccatgaccga ggacacgtct acagacacag cctacatgga
      361 gctgagtggc cttacatctg aggacacggc cgtgtattac tgtgcgaccc acggagggta
      421 tagcgacatc tggacctccc tatataacgg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004027             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9710:9350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004027
VERSION     KCXD01004027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9710:9350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..445
     V_segment       79..372
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62509.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       387..392
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..445
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          100 a          127 c          133 g           87 t
ORIGIN      
        1 acatggggac agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca
       61 gctacaggcg cccgctctga ggtccagctg gtgcagtccg gggctgaggt gaagaagcct
      121 ggggcctcag tgaaggtctc ctgcaaggtt tccggataca ccttcaccga attctccacg
      181 cactgggtgc gacaggcccc tggaaaaggg cttgagtgga tgggaggtgt tgatcctgca
      241 tatggtgaaa tgacacacgc agaaaacttc cagggcagac tcaccatgac cgaggacacg
      301 tctacagaca cggcctacat ggagctgagc agcctgagat ctgaggacac ggccgtgtat
      361 tattgtgcga gatcatccag cggtacgtgg ctatactggt acttcgatac ctggggccct
      421 ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01004028             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10571:20263
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004028
VERSION     KCXD01004028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10571:20263"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62510.1"
                     /translation="CVRESYSGNYYFNRFDVW"
     D_segment       401..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          135 c          133 g          111 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctttggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccagtagc aataattact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacat atctctggta gtggtgggag gaccgactac aacccctccc tccagagtcg
      301 agtcaccatt tcaactgaca cgtccaagag ccagttctcc ctgaagttga gctctgtgac
      361 cgccgcggac acggccgtct attactgtgt aagagagtca tatagtggta attattactt
      421 caaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004029             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17205:10700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004029
VERSION     KCXD01004029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17205:10700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62511.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       430..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          124 c          157 g          115 t
ORIGIN      
        1 acatgggggg agaggagccc agcactggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaggtggt ggagtctggg ggcggcttgg caaagcctgg
      181 gggatccctg agactctcct gtgcagcctc tggattcacc ttcagtacct atgctatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcagccatta gtgttggtgg
      301 tagtacatac tacgcagact ccgtgagggg ccgattcacc atctccagag acaactcaga
      361 gagcacgctc tccctgcaaa tgaacagcct gagtactgag gacacggccg tgtattactg
      421 tgccaaaggg gatacagcta cagtttatta cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004030             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12061:14602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004030
VERSION     KCXD01004030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12061:14602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62512.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       430..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          124 c          149 g          107 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcggcca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacagtgt caccgaatta tcgcttcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgtaaaag gtgaagaaat
      301 tcacggagag gagttccagg acagagtcac catgaccgag gacccgtcta cagacacagc
      361 ctacatggag ttgagcaacc tgagatctga ggacacggcc gtgtattatt gtgcgagtgg
      421 gtttagtatc tggttatttt atgacgtttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004031             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19942:10895
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004031
VERSION     KCXD01004031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19942:10895"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62513.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       422..433
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          139 c          140 g          108 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tgatgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctttgcca tcaattgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttgggat aacaaactac
      301 gtgcagaagt tccagggcag agtcaccatt accgcggaca cgtccacaag tatagcctac
      361 atggagctga gcggcctaag atctgaggac acggccgtgt attactgttc gagagggtca
      421 aattacgagg atgcttccga ttacttttcc gcctttgact cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004032             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11948:4048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004032
VERSION     KCXD01004032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11948:4048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62514.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          139 c          137 g          101 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggttcag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaag ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcaat tggctttttt ggtacttcga tttttggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004033             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16768:19665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004033
VERSION     KCXD01004033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16768:19665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62515.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       441..454
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          112 a          121 c          165 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag gcctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttggtc tgacctgggt tttccttgtt
      121 ggtcttttga aaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agccttggct
      181 cagcctgggg ggtccctgag actctcctgt gcagcgtctg ggttcacctt cagtagctat
      241 gccatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agccatatcg
      301 tttgatggaa gtaagaagaa ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaactcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtactact gttcgaggga gtggatacag tgggcgcagt tagtgagcgg tttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004034             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19930:11107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004034
VERSION     KCXD01004034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19930:11107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62516.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       435..446
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          151 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccattgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcactaac tatggcatgc
      241 actgggtccg ccaggctcca gggaagggtc tggagtgggt ggcagttatg tcgcatgatg
      301 gaactaagaa attctacgca gactctgtga aggaccgatt caccatttcc agggacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgagatt ggaggacgcg gccgtctatt
      421 actgtgcgag gggagactac ggtaacagcc ttgactactg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004035             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10496:17029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004035
VERSION     KCXD01004035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10496:17029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62517.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          141 c          136 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcgac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aactccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ttggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004036             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6267:10606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004036
VERSION     KCXD01004036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6267:10606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62518.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          116 c          150 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat aaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcctagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004037             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13503:18392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004037
VERSION     KCXD01004037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13503:18392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62519.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          117 c          159 g          116 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacgtttgg
      241 cgtccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatggaagt aaaaagtacc acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccgag gccaagctat atcttcaaat gaacaagctg aaagtggagg acgcggccgt
      421 gtactactgt gtgagagacg cgtatggttc cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004038             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14155:15280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004038
VERSION     KCXD01004038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14155:15280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62520.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       438..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          124 c          157 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tgggggcggc ttggcgaagc
      181 ctgggggatc cctgagactc ttctgtgcag cctctggatt taccttcaat acctattcta
      241 tacactgggt ccgccaggct cccgggaagg ggctggagtg ggtctcagcc attagtagtg
      301 gtggtagaac atactacgca gactccgtga agggccgagt caccatctcc agagacaact
      361 caaagaacac agtctccctg caaatgaaca gcctgggagc tgaggacacg gccgtgtttt
      421 actgtgcgag aggggagaca gcttcagttt actacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01004039             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22070:12600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004039
VERSION     KCXD01004039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22070:12600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62521.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          113 a          145 c          132 g           91 t
ORIGIN      
        1 acatgggggg catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtgga
      301 ctacacacag aagttccgag acagactcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01004040             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12644:8365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004040
VERSION     KCXD01004040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12644:8365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62522.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          143 c          142 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggaat tgagcagcct gacatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaatctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004041             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14750:3858
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004041
VERSION     KCXD01004041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14750:3858"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..485
     V_segment       120..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62523.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       419..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>488
                     /gene="IGHG"
BASE COUNT          114 a          142 c          133 g           99 t
ORIGIN      
        1 atggggatca cacaacaacc acatccctcc cctacagaag ccccagagcg cagcacctca
       61 ccatggactg gacctggagg atcctcctct tagtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcaatct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac accttcagcg atttatccat acactggata cgacaggccc
      241 ctggaaaagg gcttcagtgg atgggaagtg ttgatcctgc ttttggtgaa atgataaacg
      301 cagagaagtt ccagggcaga gtcaccatga ccgaggacac gtcttcagac acagccttca
      361 tggaattgag cagcctgaaa tctgacgaca cggccgtgta tttctgtgcg agtggcccta
      421 gcggcacctg gatcgactgg tccttcgatg tctggggccc tggcacccca atcaccgtct
      481 cctcaacc
//
LOCUS       KCXD01004042             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12433:8185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004042
VERSION     KCXD01004042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12433:8185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..344
     V_segment       8..259
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62524.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       268..275
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..344
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           76 a           84 c          112 g           74 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caaggtttcc ggagacacct tcaccgaatt
       61 atccatgcac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaggtgttga
      121 ccctggaaat ggtgaaataa tacacgcaga tagtttccag ggcagagtca ccatgaccga
      181 ggacacgtct acagacacag cctacatgga gctgagcggc ctgagatctg aggacacggc
      241 cgtgtattac tgtgcgagag gggggttcgg tagcagtgtc tggtccaatc tcgtttatgg
      301 tttggattcc tggggccaag gggtcgccgt caccgtctcc tcagcc
//
LOCUS       KCXD01004043             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12861:13714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004043
VERSION     KCXD01004043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12861:13714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62525.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          109 a          145 c          132 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaagtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt
      181 ctcctgcagg atttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctgtatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctact tggaactgag
      361 cggcctgact tctgaggaca cggccgtgta ttactgtgcg actggcccta ccggcacctg
      421 gaacgcctgg tacctcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01004044             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18720:20421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004044
VERSION     KCXD01004044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18720:20421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62526.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          119 c          154 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggggg aggcttggtt
      181 cggccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt caatagtttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtgtc agttatatcg
      301 tctgatgaaa gtaagaaata ttacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa gtgaacaacc tgaagctgga ggacacggcc
      421 ctctattact gtgcgagaga cgcatatggc agcggctgtg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004045             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:17805:10925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004045
VERSION     KCXD01004045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:17805:10925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..398
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62527.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       408..413
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT          111 a           98 c          142 g          110 t
ORIGIN      
        1 acatggggga gagatcgagt gggagtggac atgagtaaga gaaacagtgg atatatgtgg
       61 cagttcctga ccttggtgtc tctctgtttg caggtgtcca gtgtgaggtg caactggtgg
      121 agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt gcagcctctg
      181 gattcacctt cagcaccttt ggcatacact gggtccgcca ggctccaggg aaggggctgg
      241 agtgggtggc agttatatca tatgatgaaa ctaagaaata ctacacagac tctgtgaggg
      301 accgattcac catctccaga gacaattcca aaaacatggt atattttcaa atgaacaacc
      361 tgaaattgga ggacacggcc atatattact gtgcgagaga tgtcagggga acggggtttg
      421 acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004046             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:25802:15071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004046
VERSION     KCXD01004046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:25802:15071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62528.1"
                     /translation="CARDPQWQLELLFFDYW"
     D_segment       405..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          142 c          132 g          103 t
ORIGIN      
        1 acatgggggc tctctgagaa tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggtccagga ctggtgaagc cctcggagac cctgtccctc acgtgcgctg tctctggtgg
      181 ctccttcagc aatttctact ggagttggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggctat atcaacggtg atagtggcag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagacg cgtccaaaaa gcagttctcc ctgaggctga cctctatgac
      361 cgccgcggac acggccgtat attactgtgc gagagacccc cagtggcagc tggaactcct
      421 cttttttgac tactggggcc agggagtcct ggttaccgtc tcctcagcc
//
LOCUS       KCXD01004047             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14164:5895
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004047
VERSION     KCXD01004047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14164:5895"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..399
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62529.1"
                     /translation="CARDTTFTGRYDYW"
     D_segment       402..408
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           97 a          133 c          133 g          102 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gagtggtgaa gccttcgggg accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcatcagtta caggtggagc tggatccgcc agcccccagg gaagggactg
      241 gagtggattg gatacatcta tggtagtagt gcgagcacaa actacaaccc ctccctcaaa
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccttgaa gctggactct
      361 gtgacggccg cggacacggc cgtgtattac tgtgcgagag atactacctt taccggcagg
      421 tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004048             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18270:14744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004048
VERSION     KCXD01004048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18270:14744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..447
     V_segment       90..386
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62530.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       397..401
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           92 a          137 c          124 g           96 t
ORIGIN      
        1 acatgggagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc ttcctcctcc
       61 tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg ggcccaggac
      121 tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc gccatcagca
      181 gtggtttcta ctggacctgg atccgccaac ccccaggaaa ggggctggag tggattgggt
      241 gtatcggagg taatagtggt accacctact acaacccctc cctcaagagt cgagccacca
      301 tttcaaaaga cacgtccaac aatcaactct ccctgaagct gagttctgtg accgccgcgg
      361 acacggccgt gtattactgt gcgagagatg aagacccctc catttttgac tactggggcc
      421 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004049             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23412:6256
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004049
VERSION     KCXD01004049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23412:6256"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62531.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          124 a          138 c          136 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaggtggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctaaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004050             337 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23153:16303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004050
VERSION     KCXD01004050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23153:16303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..335
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..335
     V_segment       10..262
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <257..>304
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62532.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       263..269
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..335
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        336..>337
                     /gene="IGHG"
BASE COUNT           80 a           89 c           93 g           75 t
ORIGIN      
        1 acatgggggg cctggggcct cagtgaaggt ctcctgcaag gtttccggat acaccttcac
       61 cgaattatcc atacactggg tgcgacaggc ccctggaaaa ggccttgagt ggatgggagg
      121 ttttggtcct gtgtatggtg aaataataca cacagagaag ttccagggca gagtcactat
      181 gaccgaggac acgtctacag acacagccta catggagctg agcagcctga gatctgagga
      241 cacggccgtc tattactgtg cggcagctga tagtggttac ccattttact acttcgatat
      301 ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01004051             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7717:11815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004051
VERSION     KCXD01004051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7717:11815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62533.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          114 a          116 c          150 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtagttatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaatatgata tatctgcttt tgaataccct gaaattggag gacacggccg
      421 tgtattactg tgtgagagtc catgactacg ccatgtacta ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004052             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18463:7065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004052
VERSION     KCXD01004052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18463:7065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62534.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          137 c          137 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcactg tctctggtgg
      181 ctccttcagt ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa tcaattctcc ctgaagctga cctctatggc
      361 cgccgcggac acggccgttt atttctgtgc cagagatgcg ggagtgggag ccacaatcct
      421 ttactactat gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004053             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10942:8301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004053
VERSION     KCXD01004053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10942:8301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62535.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          141 c          131 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actaccaccc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc agcaatcaac tctccctgaa gctgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggcgt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004054             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20870:5241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004054
VERSION     KCXD01004054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20870:5241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..461
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62536.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>467
                     /gene="IGHG"
BASE COUNT           95 a          135 c          129 g          108 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcac ctgcaggagt
      121 cgggcccagg actggtgaag tcttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 actccatcag caatagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01004055             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20382:2264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004055
VERSION     KCXD01004055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20382:2264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62537.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       435..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          111 a          112 c          148 g          120 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcagctt cagtaactct ggcattcact
      241 gggtccgcca ggctccaggg gaggggctgg agtgggtgtc agttatatcg tatgatgaaa
      301 gtaagacata ctacgcagac tctgtgaagg accgattcac catttccaga gacaattcca
      361 agaacatggt acatcttcaa atgaacaccc tgaatttgga ggacacggcc gtatattact
      421 gtgtgagaga ttcttacggt agaggctttg accagtgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004056             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21189:19912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004056
VERSION     KCXD01004056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21189:19912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    97..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        97..463
     V_segment       97..384
                     /gene="IGHV3-141"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62538.1"
                     /translation="CSFKYYEDDDGYYFSDW"
     D_segment       393..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          100 a          101 c          143 g          121 t
ORIGIN      
        1 acatgggggg tgatcagcac tgaacacaga ggactcacca tggagtttgt gctgagctgg
       61 gttttccttg ttgctatttt aaaaggtgtc cagtgtgaag tgcagctggt ggagtctggg
      121 ggaggcttgg taaagcctgg agggtccctg agactctcct gtgcagcctc tggattcacg
      181 tttgatgatt atgccatgag ctgggtccgc caggctccag ggaagggtct ggagtgggta
      241 tctcggatta gttgggatgg tggtataact tattacgcag actccgtgaa gggccgattc
      301 accgtctcca gagacaacgc caagaacaca ctgtatctcc aaatggacag cctgagagct
      361 gaggacacgg ccttgtatta ttgtagtttt aagtattacg aggatgatga cggttactat
      421 ttctccgact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004057             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20922:13059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004057
VERSION     KCXD01004057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20922:13059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62539.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       426..433
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          110 a          139 c          144 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gtagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctgc agtgaagagg cctggggcct cagttaaggt
      181 ctcctgcaag gtttccggat actccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtgtatggtg aagaaataca
      301 cgcagagaat ttccaggaca gagtcaccat gaccgaggac acgtccacag acacagccta
      361 catggagctg agcagcctga gacgtgagga cacggccgtg tatttctgtg cggcgggcct
      421 tggggggtat ttagttctta ctgaatacct cgaattctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01004058             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14570:13677
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004058
VERSION     KCXD01004058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14570:13677"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..477
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62540.1"
                     /translation="CARVGEDSGGAEDLDFW"
     D_segment       414..421
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          109 a          106 c          145 g          119 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca ggacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gagatacaac
      121 tggtggagtc tggaggaggc ttggttcagc ctggggggtc cctgagactc tcctgtgcag
      181 cctctggatt caccttcagt agctttggca tgcactgggt ccgccaggct ccagggaagg
      241 gactggaatg ggtggcactt atatcgtatg atggagataa gaaatactac gcagactctg
      301 tgaaggaccg attcaccctc tccagagaca attccgagaa catcctatat cttcaaatgt
      361 acaacctgaa attggaggac acggccgtgt atttctgtgc gagagttgga gaggatagtg
      421 gtggtgcgga ggaccttgac ttctggggcc aaggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004059             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14630:14555
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004059
VERSION     KCXD01004059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14630:14555"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62541.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          144 c          138 g           98 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag ggtcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 ccctgcaagg cttctggata caccctcagc atctctacca tcagttgggt acgacaggcc
      241 cctggacaag ggcttgagtg gatgggggag atcttccctc ttgttggtaa aacaaaatac
      301 gcacagaagt tccacggcag agtcacgatt accgcggaca cgtccgcaag tacagcctac
      361 atggagctga gcggcctgaa atctgaggac acggccgtct attactgtgc gaaaagaggt
      421 ggccacggta ccaccaccac gttgtacttc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004060             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12230:14810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004060
VERSION     KCXD01004060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12230:14810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..343
     V_segment       10..265
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <259..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62542.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       270..284
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..343
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           71 a          104 c           98 g           72 t
ORIGIN      
        1 acatgggaga ggcccgggga atctctgagg atctcctgtc agacttctgg atacagtttt
       61 gccaactact ggatcgcctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg
      121 atcatctatc ctggtgattc tgacaccaag tacggcccgt ccttcgaagg ccaggtcacc
      181 atctcagccg acaagtccac cagcaccgcc tacctgcagt ggagcagcct gaaggcctcg
      241 gacaccgcca cgtattactg tgcgagactc tggggtgatt attacgcact ccagtactac
      301 ttcgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004061             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17667:4986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004061
VERSION     KCXD01004061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17667:4986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62543.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       439..444
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          108 a          110 c          153 g          121 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcatgt tcagtaactt tggcatccac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgt cagttatatc gtatgatgta
      301 actgtgaaat actacgcaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaacacgc tatatcttca aatgcacaac ctgaaattgg aggacacggc cgtgtattat
      421 tgtgtgagag atgtcagggg aacggggttt gacttctggg gccagggagt cctggtcacc
      481 gtctcgtcag cc
//
LOCUS       KCXD01004062             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15005:10801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004062
VERSION     KCXD01004062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15005:10801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62544.1"
                     /translation="CASGPSGNWNGWYFDIW"
     D_segment       425..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          144 c          139 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 gggcccctgg aaaaggtctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tcgagacaga gaacttccag ggcagagtca ccctgaccga agacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggactcggc cgtgtattac tgtgcgagtg
      421 gccctagcgg caactggaac ggctggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004063             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5251:8591
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004063
VERSION     KCXD01004063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5251:8591"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62545.1"
                     /translation="CAREWIQWTQLVSGLDSW"
     D_segment       441..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          117 a          112 c          165 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagatggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtcactgag actctcctgt gtaggctctg gattcagttt caatacctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtcatatcg
      301 tttgatggaa gtaagaagta ctacgcagac tctgtgaagg accgactcac catctccaga
      361 gacaattcca agagtacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgaggga gtggatacag tggacacagt tagtgagcgg tttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004064             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22192:14917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004064
VERSION     KCXD01004064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22192:14917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62546.1"
                     /translation="CARGRGVIIVFFDYW"
     D_segment       439..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          103 a          123 c          154 g          121 t
ORIGIN      
        1 acatgggggc tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccaatgtga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gttttggtaa atatgacatg
      241 cattgggtcc gccaggctcc gggaaagggc ctggagtggg tctcatccat tagtaacgct
      301 ggtgaaaccg tcaaatacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaact cgctgtctct acaaatgagc agcctgagag ccgaggacac ggccgtctat
      421 tactgtgcta gaggtcgagg ggtgattatc gtcttctttg actactgggg ccggggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004065             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16700:16629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004065
VERSION     KCXD01004065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16700:16629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62547.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       404..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          142 c          129 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtgtcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtagcttct ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtct atctatggtg ctactgggag caccacctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgagactga gctctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gacgatgatt acggttccta
      421 ttaccttgac tactggggcc agggagtcct ggtccccgtc tcgtcagcc
//
LOCUS       KCXD01004066             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:26890:11939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004066
VERSION     KCXD01004066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:26890:11939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62548.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..444
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          113 c          153 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttactattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcac cttcagtact tatggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgaatgacg
      301 ggagtaaaat atactacgca gaatctgtga aggaccgact caccatctcc agagacaatt
      361 ccgaggccaa tgtatatctt caaatgaata acctgaaatt ggaggacacg gccgtgtact
      421 attgtgtgag agatgcgttt ggttccggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004067             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17562:20100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004067
VERSION     KCXD01004067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17562:20100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62549.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           92 a          132 c          136 g           99 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtgtctgga
      181 ggctccatca gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg gatgtatcta tgatagcagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaat agacacgtcc aagaaccagt tctccctgaa ggtgaggtct
      361 atgaccgccg cggacacggc cgtgtatcac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggtc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004068             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5480:12596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004068
VERSION     KCXD01004068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5480:12596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62550.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       421..428
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          138 c          151 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgaccctgca aatggtgaaa taatacacgc
      301 agatagtttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gaggggggtt
      421 cggtagcagt gtctggtcca atctcgtcta tggtttggat tcctggggcc aaggggtcgc
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004069             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:25507:7298
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004069
VERSION     KCXD01004069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:25507:7298"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62551.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          134 c          136 g          103 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc aggtgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattgga tacatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004070             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13189:6185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004070
VERSION     KCXD01004070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13189:6185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62552.1"
                     /translation="CARGLPTVFGMVITELW"
     D_segment       412..427
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..469
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           89 a          140 c          133 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcgcttacta ctggagctgg atccaccagc ccccagggaa ggggctggag
      241 tggattgggc atataagtgt cagtcttggg agcaccgcct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagtt gaactctgtg
      361 accgccgcgg acacggccgt gtttttttgt gcgagaggac ttcctacagt ttttggaatg
      421 gttattacgg aactctgggg cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004071             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:9120:13236
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004071
VERSION     KCXD01004071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:9120:13236"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..507
     V_segment       126..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62553.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       428..451
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          115 a          143 c          146 g          105 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagttggtg cagtccgggg ctgaggtgaa gaggcctggg gcctcagtga
      181 agctctcctg caaggctcct ggatacatct tcagcatatc tgccatcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagggatcat ccctcttgtt ggtgtaacaa
      301 cctacgcaca gaacttccag gacagagtca cgattaccgc ggacacgtcc acaagcacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgagtg
      421 gcggcttcga ggatgataac ggtcactatt atacgacact aacatttcac gagtggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004072             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22565:6484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004072
VERSION     KCXD01004072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22565:6484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62554.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       409..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          137 c          129 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggatctggat ccgccagccc ccagggaagg gactggagtg
      241 gatagggtct atctatggtg ctactgggag caccttttac gacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctgg actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gcgatatagc gatactgata gttattacta
      421 ctttgattac tggggccagg gagtccgggt caccgtctcc tcagcc
//
LOCUS       KCXD01004073             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9747:15865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004073
VERSION     KCXD01004073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9747:15865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..439
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62555.1"
                     /translation="CARNSYYYDIGYYYYGLDSW"
     D_segment       446..468
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..521
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          112 a          124 c          157 g          130 t
ORIGIN      
        1 acatggggga gctctgagag aggagcctta gccctggatt tcaaggcact tccacctggg
       61 gatcagcact gaacacagag gacccaccat ggagttgggg ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcaactggag gagtcagggg gaggcttggt
      181 ccagcctgga gggtccctga gactctcctg tgtagcctca ggattcacct tcagtaatta
      241 cgacatgagc tgggtccgcc aggctccggg aaaggggctg gagtgggtct catatgtcag
      301 ttacactggt ggaaccatat actacgctga ctccgtgaag ggccggttca ccgtctctag
      361 agacgacgcc aagaactcgc tgtctctgca aatgtgcagc ctaagagccg aggacacggc
      421 cgtgtattac tgtgctagaa attcctatta ctatgatatt ggttattatt attatggttt
      481 ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01004074             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13590:8464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004074
VERSION     KCXD01004074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13590:8464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62556.1"
                     /translation="CARDGIAAAGVDYW"
     D_segment       403..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           87 a          137 c          140 g           98 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa gggcctggag
      241 tggattggat atatcggtgg tcataatggg aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaataga cacgtccaag aaccagttct ccctgaaatt gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgcgcgatg ggatagcagc ggcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004075             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14868:10710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004075
VERSION     KCXD01004075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14868:10710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62557.1"
                     /translation="CARDAYGSGCDFW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          115 c          148 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggtttg gttcggcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tttggcattc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa attctatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctcaagtt ggaggacacg gccgtctatt
      421 actgtgcgag agacgcatat ggcagcggct gtgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004076             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19512:13851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004076
VERSION     KCXD01004076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19512:13851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..453
     V_segment       81..374
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <366..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62558.1"
                     /translation="CTRIGFGSLAAAGHYFDYW"
     D_segment       391..404
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           88 a          112 c          142 g          113 t
ORIGIN      
        1 acatgggctg aacacagagg accatggagt tggggctgag ctgggttttc cttgttgcta
       61 ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggagac ttggtccagc
      121 ctggggggtc cctgagactc tcctgtgtag cctctggatt cacctttgct gattatggca
      181 tgcactgggt ccgccaggct ccgggaaagg ggctggagtg ggtctcatcc attgatagga
      241 cggctaaaac cgtctactac gctgactccg tgaggggccg attcaccatt tccagagaca
      301 acgccaagaa ctcgctgtct ctgcaaatga gcagcctgag agccgaggac acggccgtgt
      361 atttttgtac tagaattggc tttggatctc tagcagcggc tggtcactac tttgactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004077             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:22349:10013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004077
VERSION     KCXD01004077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:22349:10013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62559.1"
                     /translation="CARVRGGIAGYFDYW"
     D_segment       446..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          115 c          158 g          125 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgacgtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agttacttct
      241 ggatgtactg ggttcgccag gcaccaggaa aggggctgga gtggatctca gttattgata
      301 gtggtggtga taacacatac tatgcagact ccatggaggg ccgattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tgaacagcct gagtgctgag gacacggctg
      421 tctatttctg tgcgagagtc agggggggta tagcagggta ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004078             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19834:5400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004078
VERSION     KCXD01004078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19834:5400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62560.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       436..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          106 a          124 c          159 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactca acacagaaca taccatggag tatgtgctga gttgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggggata gcacatacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004079             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:21842:10305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004079
VERSION     KCXD01004079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:21842:10305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62561.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          140 c          138 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaggtacag gcgcccactc
      121 tgaggtccag ctggtgcagt cgggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtttttggtg aaataatgaa
      301 ttcagagaag ttccagggca gagtcgcctt gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgcg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tgtctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004080             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16031:19259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004080
VERSION     KCXD01004080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16031:19259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62562.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       416..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          140 c          131 g           96 t
ORIGIN      
        1 acatggggga cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtaaaggag cctggggcct cagtaaaggt
      181 ctcctgcaag gtttccggat tcaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaaaca
      301 cacagagttc catgccagat tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttgagc agcctaagat ctgaggacac ggccctgtat tactgtgcag tcggctatag
      421 cggcagatgg aacaactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01004081             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5147:7801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004081
VERSION     KCXD01004081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5147:7801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62563.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          130 c          138 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 gtctatcaga agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atctatggga gtgatagtag taccaattac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagttga gcgctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004082             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13038:11861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004082
VERSION     KCXD01004082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13038:11861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62564.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          120 a          143 c          134 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aaccctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacttggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacctc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004083             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20306:6066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004083
VERSION     KCXD01004083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20306:6066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62565.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           96 a          140 c          136 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatcagtgc tagtagtggg accaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga cacgtccaag aacctcttct ccctgaacct gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagaga aatactatag tggtagttat
      421 aaacacaact ggttcgatgt ctggggcccg ggagtcctgg tcgccgtctc ctcagcc
//
LOCUS       KCXD01004084             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7841:17229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004084
VERSION     KCXD01004084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7841:17229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..480
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62566.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       410..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>484
                     /gene="IGHG"
BASE COUNT          116 a          141 c          130 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccgactaca ccttcgccga attacccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggttt tgctagtata tatggtgaaa taatacatac
      301 agagagattc cagggcagag tcaccatgac agcggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtgtat tactgtgcgg cagctgatag
      421 tggttaccca ttttactact tcgatatctg gggccctggc accccgatca ccatctcctc
      481 cgcc
//
LOCUS       KCXD01004085             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21771:9542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004085
VERSION     KCXD01004085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21771:9542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62567.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          118 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 gacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcgtccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gtatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004086             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15545:8860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004086
VERSION     KCXD01004086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15545:8860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62568.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       437..448
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          110 a          116 c          154 g          116 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccattgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 gggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actatggcat
      241 gcactgggtc cgccaggctc cagggaaggg tctggagtgg gtggcagtta tgtcgcatga
      301 tggaactaag aaattctacg cagactctgt gaaggaccga ttcaccatct ccagggacaa
      361 ttccaagaac atggtatatc ttcaaatgaa caacctgaga ttggaggacg cggccgtcta
      421 ttattgtgcg agaggagact acggtaacag ccttgacttc tggggccagg gagtcctgct
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004087             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22330:12618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004087
VERSION     KCXD01004087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22330:12618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62569.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          115 c          153 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 cattcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagacatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtgt atcttcaaat gaacaacctg aaattggagg acacggccat
      421 atattactgt gcgagagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004088             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:22883:17661
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004088
VERSION     KCXD01004088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:22883:17661"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62570.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          139 c          151 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004089             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13590:9936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004089
VERSION     KCXD01004089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13590:9936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62571.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       439..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          102 a          120 c          159 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actcgacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc caatgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact attacatgac
      241 ctgggtccgc cagcctccag ggaaggggct ggagtggatc tcgggtattg acagtggggg
      301 gggtagtgca tactatccag actccgtgaa gggcagattc atcatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagacct gaagacacgg ctgtctatta
      421 ctgtgcgaga gtcgtgggtg gtagtgctgg atactttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004090             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14970:11541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004090
VERSION     KCXD01004090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14970:11541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62572.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       405..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           97 a          140 c          137 g          105 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg atatatcagt gctagtagtg ggaccaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaga gacacgtcca agaacctctt ctccctgaac ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga gaaatactat agtggtagtt
      421 ataaacacaa ctggttcgat gtctggggcc cgggagtcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01004091             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:5373:8827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004091
VERSION     KCXD01004091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:5373:8827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..461
     V_segment       108..396
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62573.1"
                     /translation="CASGGIAATGPDSW"
     D_segment       400..418
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           77 a          141 c          141 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atggatcctg tcccaagtgc agctgcggga
      121 gtcgggcccg ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgtctccatc agcggttact ggtggggctg gatccgccag cccccaggga agggactgga
      241 gtggattggg tttttcggtg gtagtcttgg ggacccctac taccactcct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa taaccggttc tccctgaggc tgacctctgt
      361 gaccgccgcg gacacggccg tttattactg tgcgagcggg ggtatagcag cgactggtcc
      421 ggactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004092             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11862:3307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004092
VERSION     KCXD01004092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11862:3307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62574.1"
                     /translation="CAREGISASGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          134 c          145 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacgtact acaacccctc cctcaagatt
      301 cgagtcacca tttcaccaga cacgtccaaa gagcagttct ccctgaggct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc gtcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004093             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11083:11489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004093
VERSION     KCXD01004093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11083:11489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..339
     V_segment       1..267
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62575.1"
                     /translation="CATRAPRWFYDSDHKW"
     D_segment       294..299
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..339
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           70 a          106 c           94 g           71 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcacatgcgc tgtctctggt gactctatca
       61 ccagtactaa ctggtggacc tggatccgcc agcccccagg gaaagggctg gagtggattg
      121 ggtatatcag tggtaggagc ggtagcacct cctacaaccc ctccctcaag agtcgagcca
      181 tcatttcaac agacacgccc aagaaccagt tctccctgca gctgagctct gtgaccgccg
      241 cggacacggc cgtgtattat tgtgcgacta gggccccccg atggttctat gacagtgatc
      301 acaagtgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004094             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10108:15568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004094
VERSION     KCXD01004094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10108:15568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62576.1"
                     /translation="CARWGTPFDYW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           91 a          134 c          130 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtag
      181 ctccatcaac agtggttatg cctggagttg gatccgccag cccccaggga aggggctgga
      241 gtgggttgga catatctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccaattc tccctgaagc tgaactctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004095             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27827:9696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004095
VERSION     KCXD01004095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27827:9696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62577.1"
                     /translation="CAKGETATPYYGLDSW"
     D_segment       437..445
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          128 c          152 g          111 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgaga tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcagta cctatgctat
      241 acactgggtc cgccaggctc cagggaaggg actggagtgg gtctcagcta ttagcactgg
      301 tggtaggaca ttctacgcag actccgtgaa gggccgattc accatctcca gagacaactc
      361 aaagaacacg ctctccctgc aaatgaacag cctgagagct gaggacacgg ccatgtatta
      421 ctgtgcgaaa ggggaaacag ctacacctta ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004096             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17045:9696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004096
VERSION     KCXD01004096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17045:9696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..397
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62578.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       413..420
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          100 a          139 c          130 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgaagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctatcagc ggtgtttatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatgtccatg gtgaaactgg aaacaccgac tacaacccgt ccctcaagaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccttgacgc tgaggtctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagacgc ccagaaaaca gttactactt
      421 ctactacttt gactactggg gccacggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004097             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16563:4119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004097
VERSION     KCXD01004097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16563:4119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62579.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          111 c          158 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga tttactttca gtagtagtgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctggctg ttgaatcgca
      301 tgatggaaat aagaaatact atgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacagcctg aaattggtgg atacggccat
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004098             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12316:11111
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004098
VERSION     KCXD01004098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12316:11111"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62580.1"
                     /translation="CARDVYGGGLDYW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ctcctcgttg
      121 ctattttaag aggtgtccag tgtgaggtct acctggtgga gtctggagga ggcttggttc
      181 agcctggtgg gtccctgaga ctctcctgtg cagcctcagg attcaccttc agcaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaaaga ccgattcacc atatccagag
      361 acagctccaa gaatatgcta tatcttctac tgaacaacct gaaattggag gacacggcca
      421 tgtattattg tgcgagagat gtatatggtg gggggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004099             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17037:12406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004099
VERSION     KCXD01004099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17037:12406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62581.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          138 c          135 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gcgacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatattggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01004100             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6383:6873
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004100
VERSION     KCXD01004100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6383:6873"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62582.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          134 c          130 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtggctt ctggaactgg atccgccaga ccccagggaa ggggctggag
      241 tggattgggt acatttatgg tagtactggg aacaccggct ataacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcaaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtattattgt gcgagatatg gagatgatag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004101             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8089:10093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004101
VERSION     KCXD01004101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8089:10093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62583.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          126 c          147 g          115 t
ORIGIN      
        1 acatgggggg gaaaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaattgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct cagactctcc tgtgcagcct ctggattcac cttcagtacc tattctatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctatt agtactgctg
      301 gtagcacata ctacacagac tccgtgaagg gccgattcag catctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgaacagcc tgagaactga ggacacggcc ctgtattact
      421 gtgcgaaagg ggaaacagct tcagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004102             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13345:14862
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004102
VERSION     KCXD01004102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13345:14862"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62584.1"
                     /translation="CARDVKGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          115 c          149 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgac gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt ggcagttatt tcgtatgatg
      301 aaactaagaa atacttcgca gactctgtga gggaccggtt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcaag ggaacggggt ttgacttctg gggccaggga gccctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004103             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:2992:11476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004103
VERSION     KCXD01004103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:2992:11476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62585.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       426..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          121 a          147 c          142 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagcc accggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagttaa gaagcctggg gcctcagtga
      181 tggtctcctg ccaggtttcc ggatacaccg tcaccgaaat ttccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttgc tcctgaaaaa aatgagttaa
      301 tacacgcaga caagttccag gacagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtggc ctgacatctg aggacacggc cgtgtattac tgtgcgaccc
      421 acggagggta tagcgacatc tggaactccc tatatcacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004104             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11059:3733
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004104
VERSION     KCXD01004104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11059:3733"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62586.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       441..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          112 c          151 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tcttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgacagttat atcgtatgat
      301 gaaagtaaga aatactacgc agactctctg aaggaccgat tcaccatttc cagagacaat
      361 tccaagaaca cggtatatct tcaaatgaac aacctgcaat tggaggacac ggccgtgtat
      421 tactgtgcga gagatgataa tggggtgctt atcgacttct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004105             312 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8866:6795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004105
VERSION     KCXD01004105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 312)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 312)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8866:6795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..310
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..310
     V_segment       7..225
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>279
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62587.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       229..248
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       261..310
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        311..>312
                     /gene="IGHG"
BASE COUNT           68 a           85 c           91 g           68 t
ORIGIN      
        1 acatggggat acaccttgag catctatgtc atcagttggg tgcgacaggc ccctggacaa
       61 gggcttgagt ggatgggagg catcttccct cttgttggta caacaaacta cgcacagaag
      121 ttccagggca gagtcacgat taccgcggac acgtccacaa gcacagccta catggacctg
      181 agcagcctgg gatctgggga cacggccgtc tattattgtg cgagaggcta ctgtactggt
      241 agtggttgta accttacatt caaccggctc gatgtctggg gcccgggagt cccggtcacc
      301 gtctcctcag cc
//
LOCUS       KCXD01004106             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6349:16066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004106
VERSION     KCXD01004106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6349:16066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62588.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       442..453
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          118 c          154 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca ttgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcca ggctccaggg aagggtctgg agtgggtggc agttatgtcg
      301 catgatggaa ctaagaaatt ctacgcagac tctgtgaagg accgattcac catctccagg
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgagattgga ggacgcggcc
      421 gtctattatt gtgcgagagg agactacggt aacagccttg acttctgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01004107             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14952:11348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004107
VERSION     KCXD01004107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14952:11348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62589.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       267..271
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           75 a           80 c           92 g           74 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      121 tctgatggaa gtaagaaata ctacgcagac tctttgaaag accgattcac catatccaga
      181 gacaactcca agaacatagt atatcttcaa ctgaacagcc tgaaattgga ggacacggcc
      241 gtgtattact gtgcgagaga tgtgtatggc tcggggcttg actactgggg ccagggagtc
      301 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01004108             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21239:6623
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004108
VERSION     KCXD01004108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21239:6623"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62590.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          114 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga gctgcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tttcttcaaa tggacaacct gaaattggag gacacggccg
      421 tctattattg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004109             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18380:16414
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004109
VERSION     KCXD01004109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18380:16414"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62591.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       444..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          110 c          157 g          117 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agcttcagta tctttggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tgtcgaatga
      301 tggaagtaag aaatactaca cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaaa atgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttattgcgcg agagacgatt ttggcagcgg cttagggtac tggggccagg gagccctggt
      481 gaccgtctct tcagcc
//
LOCUS       KCXD01004110             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12872:3606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004110
VERSION     KCXD01004110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12872:3606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62592.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          116 a          143 c          130 g           89 t
ORIGIN      
        1 acatggggga cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggga aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccact tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004111             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14065:18822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004111
VERSION     KCXD01004111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14065:18822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62593.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          117 c          160 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacgtttg
      241 gcgtccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaag taaaaagtac cacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccga ggccaagcta tatcttcaaa tgaacaagct gaaagtggag gacgcggccg
      421 tgtactactg tgtgagagac gcgtatggtt ccggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004112             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:22581:21714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004112
VERSION     KCXD01004112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:22581:21714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..506
     V_segment       128..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62594.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       434..446
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..506
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          116 a          139 c          153 g          100 t
ORIGIN      
        1 acatggggga gagcatcaca caacaaccac atccctcccc tacagaagcc ccagagcaca
       61 gcacctcacc atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc
      121 ccactctgag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
      181 aaaggtctcc tgccaggttt ccggatacac cttcagtgag atgtccatgc actgggtgcg
      241 acaggcccct ggaaaagggc ttgagtggat gggatgtgtt gctcctggaa atggtgaaat
      301 aatacacgca gagaacttcc aggacagagt caccatgacc gaggacacgt ctatagacat
      361 agcctacatg gagctgagta gcctgagatc tgaggacacg gccgtgtatt actgtgcgac
      421 agggaggttc gggagcagcg tctggtccag cctcttctac ggtttggatt cctggggcca
      481 aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01004113             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17533:15022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004113
VERSION     KCXD01004113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17533:15022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62595.1"
                     /translation="CARYSDIDTYYYFDYW"
     D_segment       451..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          103 a          148 c          133 g          121 t
ORIGIN      
        1 acatggggac atttccttaa attcagggtc cagcttacat ggcaaatgct ctctgagagt
       61 catggacctc ctgtgcaaga acatgaagca cctgtggttc ttccttctcc tggtggcagc
      121 tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg ggcccaggac tggtgaagcc
      181 ttcggagacc ctgtccctca cctgcgctgt ctctggtgac tccatcagca gtagcttctg
      241 gatctggatc cgccagcccc cagggaaggg actggagtgg atagggtcta tctatggtgc
      301 tactgggagc accttttacg acccctccct caagagtcga gtcaccattt caacagacac
      361 gtccaagaac caactttccc tgaagctggc ctctgtgacc gccgcggaca ccgccgtgta
      421 ttactgtgcg agatatagcg atattgatac ttattactac tttgactact ggggccaggg
      481 agtccgggtc accgtctcct cagcc
//
LOCUS       KCXD01004114             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23540:8318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004114
VERSION     KCXD01004114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23540:8318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62596.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          121 a          141 c          134 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggttaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaatttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacttgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004115             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16144:13984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004115
VERSION     KCXD01004115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16144:13984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62597.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          119 c          146 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcacctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagttcct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat cgtatgatga
      301 aactaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtttatta
      421 ctgtgcgaga gattcttacg gtcgaggctt tgactcctgg ggccagggag tcccggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004116             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9081:22359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004116
VERSION     KCXD01004116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9081:22359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62598.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       437..441
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          107 a          112 c          156 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tatatctggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtgtcagt tatatcgtct
      301 gatggaagta agaaatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattcaaaaa acatggttta tcttcaaatg aacaacctga agttggagga cacggccgtg
      421 tatttctgtg tgagagatgc cttcgggggc ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004117             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13257:17813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004117
VERSION     KCXD01004117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13257:17813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62599.1"
                     /translation="CARWGTPFDYW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           88 a          133 c          134 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggct
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtag
      181 ctccatcaac agtggttatg cctggagctg gatccgccag cccccaggga aggggctgga
      241 gtgggttggg catatctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaatcagttc tccctgaagc tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004118             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11804:14931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004118
VERSION     KCXD01004118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11804:14931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62600.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       447..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          111 c          155 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcttctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcct ggctccgggg aaggggctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatact atatcttcaa atgaacaacc tgaaattgaa ggacacggcc
      421 gtatactact gtgggagaga tgataatggg gtgattatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004119             425 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20112:15404
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004119
VERSION     KCXD01004119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20112:15404"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    39..419
                     /note="immunoglobulin heavy chain variable region"
     V_region        39..419
     V_segment       39..330
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <324..>392
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62601.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       339..352
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       379..419
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        420..>425
                     /gene="IGHG"
BASE COUNT           92 a          109 c          133 g           91 t
ORIGIN      
        1 acatgggggt ggtggcagca gctacaggtg cccagtccca ggtccacctg gtgcagtccg
       61 gggctgaggt gaagaagcct ggggcctcag tgaagctctc ctgcaaggct tctggataca
      121 ccttcagcat ctcttccatc agttgggtgc gacaggcccc tggacaaggg cttgggtgga
      181 taggagggat catccctctt gttggtatga caaactacga acaggagttc cagggcagag
      241 tcacgattac cgcggacacg tccacgaata cagtcttcat ggaactgagc agcctgagat
      301 cggaggacac ggccgtctac tattgtgcga caggggtata ttaccaggat gaaaacggtt
      361 atttttatgt cggcggggac tttgactact ggggccaggg agtcctggtc accgtctccc
      421 cagcc
//
LOCUS       KCXD01004120             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5978:16428
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004120
VERSION     KCXD01004120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5978:16428"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62602.1"
                     /translation="CASGFSGRWILWYFEIW"
     D_segment       423..431
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          139 c          138 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctgggact gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtatatgg cgaaatgata
      301 gacgcagaga agttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaacagcct gagatctgag gacacggccg tgtattattg tgcgagcggc
      421 tttagcggca ggtggatcct ctggtatttc gaaatctggg gccctggcac tccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004121             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17148:16898
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004121
VERSION     KCXD01004121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17148:16898"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62603.1"
                     /translation="CAAGYSGSWNHWYFHLW"
     D_segment       421..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          149 c          137 g           95 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc aacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcgccgaat tatccattca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggcggcgttg atcctgcata tggtgaattt
      301 acacccggag agcagttcca gggcagagtc accatgaccg aggacacgtc tatagacaca
      361 gcctacatgg acctgatcag cctgaattct gaggacacgg ccgtctatta ctgtgcagcc
      421 gggtatagcg gcagctggaa ccactggtac ttccatctct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01004122             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22144:9203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004122
VERSION     KCXD01004122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22144:9203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62604.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          112 c          152 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccaatcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcc
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatgat atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattatt gtgtgagaga tgtcagggga acgggatttg actactgggg ccggggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004123             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15026:9299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004123
VERSION     KCXD01004123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15026:9299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62605.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       443..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          112 c          153 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcacc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt agttttggca
      241 tgcactgggt ccgccaggct ccagggcagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgtaagtaa gaaatactac gcagacgctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cacgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgg gagagatgat aatggggtgc ttatcgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004124             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8808:14496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004124
VERSION     KCXD01004124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8808:14496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62606.1"
                     /translation="CARYSDEDHYGDSLPQPPLYYFDFW"
     D_segment       404..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           94 a          149 c          136 g          116 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag gccctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtagcta ctggaactgg atccgccagc cctcagggaa ggggctggag
      241 tggattggat atatctatgg tagtactggg agcaccagtt acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatt ccgacgagga tcattacggt
      421 gactctttgc cccagccccc cctctattac tttgacttct ggggccgggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004125             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13472:10364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004125
VERSION     KCXD01004125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13472:10364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62607.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          117 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggact gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc ttctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cggcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatgaaag taacaaatac tacgcagact ctgtgaaggg ccgattcagc atctccagag
      361 acaattcgaa gaacatgcta tatcttcaca tgaacaccct gaaattggac gacacggccg
      421 tgtattactg tgcgacagat gcgtttggta gcgggattga ccactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004126             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10918:12525
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004126
VERSION     KCXD01004126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10918:12525"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62608.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       438..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          117 c          150 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggc tgacagttat atcgtatgat
      301 gaaactaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tggtgtatct tcaaatgaac aacctgacat ttgaggacgc ggccgtgtat
      421 tactgtgcga gagattctta cggtcgaggc tttgattcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004127             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17993:6901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004127
VERSION     KCXD01004127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17993:6901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62609.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       448..454
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..521
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          119 a          125 c          156 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagcact gaacacaaga gactcaccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcaggctct ggattcacct tcagtgacta
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaaatct tacaattacg cgacagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaaga acaccctaca tctgcaaatg agcagcctga aaatcgagga
      421 cacggccgtg tattactgtg ctagagggga tataccggct atagaggcct actacggttt
      481 ggattcctgg ggccaagggg tcgtcgtcac catctcctca gcc
//
LOCUS       KCXD01004128             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12549:2549
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004128
VERSION     KCXD01004128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12549:2549"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..483
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62610.1"
                     /translation="CANGMSGLDYW"
     D_segment       428..432
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          101 a          121 c          153 g          110 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtcgc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcaggtatt actagtggtg
      301 gtaacacata cttcgcagac tccgtgaagg gccgattcac catctccaga gacgactcaa
      361 agaacacagt ctccttgcaa atgaacagtc tgagacctga ggacacggcc gtgtattact
      421 gtgcgaatgg gatgtcaggg cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004129             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20824:10876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004129
VERSION     KCXD01004129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20824:10876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62611.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       414..423
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          144 c          135 g          101 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc ggtagttact ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gaaatagtgg tagtacctac tatagcccct ccctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccacctc tccctgaagc tgaactctgt
      361 gaccaccgcg gacacggccg tgtatttctg tgcgaacgtc ttaggcccct ggggcagctg
      421 gtcacactac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004130             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17864:9467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004130
VERSION     KCXD01004130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17864:9467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62612.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       443..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          110 a          114 c          161 g          122 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg tagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtacaactg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagtc tccggattca ccttcagtag ctttggcatg
      241 cactgggtcc gccaggctcc agggaaggga ctggagtggg tggcactgat atcgtatgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccctctc cagagacaat
      361 tccgagaaca tcctgtatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttttgtgcga gagttggaga gggtactggt ggtgcggagg actttgactt ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004131             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12201:14548
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004131
VERSION     KCXD01004131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12201:14548"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62613.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           89 a          139 c          136 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatcagtgg gagtagtggg agtaccgact acaagtcctc cctcaacagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagctct ccctgagact gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtcc ggggcgttac tatccactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004132             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21205:7041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004132
VERSION     KCXD01004132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21205:7041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..392
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62614.1"
                     /translation="CAAGYSGTWNHWYFDLW"
     D_segment       397..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..469
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          106 a          133 c          139 g           93 t
ORIGIN      
        1 acatgggtca acgcagagta catggggaga gcatagcacc tcaccatgga ctggacctgg
       61 aggatcctcc tcttggtggc agcagcaaca ggcgcccact ctgaggtcca gctggtgcag
      121 tctggggctg aggtgaagaa gcctggggcc tcagtgaagg tctcctgcaa ggtttccgga
      181 tacaccttca ccgaattatc cattcactgg gtgcgacagg cccctggaaa agggcttgag
      241 tggatgggag gcgttgatcc tgcatatggt gaatttacac ccggagagaa gttccagggc
      301 agagtcacca tgaccgagga cacgtctcta gacacagcct acatggaact gagcagcctg
      361 aactctgagg acacggccgt ctatttctgt gcagccgggt acagcggcac ctggaaccac
      421 tggtacttcg atctctgggg ccctggcacc cctatcacca tctcctcagc c
//
LOCUS       KCXD01004133             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:11170:7792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004133
VERSION     KCXD01004133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:11170:7792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62615.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       414..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           97 a          138 c          124 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggctat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 aatcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gctctgtgac
      361 cgccgcggac accgccgtat attactgtgt cagatatgaa gatgaatcca ttaactacca
      421 ctttgactat tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004134             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22705:9613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004134
VERSION     KCXD01004134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22705:9613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62616.1"
                     /translation="CSRYEDDYSDYYFDYW"
     D_segment       400..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          137 c          130 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccatca ccaatagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg tgctactggg agcgccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 acctccgcgg acaccgccgt gtattattgt tcgagatatg aggatgatta cagtgactac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004135             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20958:14449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004135
VERSION     KCXD01004135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20958:14449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62617.1"
                     /translation="CSRYIPGTTVFDYW"
     D_segment       403..412
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           91 a          142 c          125 g          103 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggaggca gctgccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcac cagtacctac tgggcctgga tccgccagcc ccccgggaag ggactggagt
      241 ggattggcta tatctatggt ggtactgaga gtaccggcta caacccctcc ctcaagagcc
      301 gggtcaccat ttcaacagac acgtccaaga accagttttc cctgaacctg aggtctatta
      361 ccgccgcgga caccgccatt tatttctgtt cgagatacat acctggaaca acggtctttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004136             309 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20659:8320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004136
VERSION     KCXD01004136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 309)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 309)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20659:8320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..307
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..307
     V_segment       7..225
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>276
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62618.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       246..253
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       263..307
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        308..>309
                     /gene="IGHG"
BASE COUNT           67 a           80 c           89 g           73 t
ORIGIN      
        1 acatggggat tcacctttgg tgattgtggc atgcactggg tccgccaggc tccgggaaag
       61 ggactggagt gggtctcatc tattagtaag actggtgaaa ccgaatacta cactgactcc
      121 gtgaagggcc gattcgccat ttccagaaac aacgccaaga actcgctgtc tctggaaatg
      181 agcagcctga gagccgagga cacggccgtg tattactgca ctagaatttg ttgtccccgt
      241 gattttagca gcgactgtca ctggttcgat gtctggggcc cgggagtcct ggtcaccgtc
      301 tcctcagcc
//
LOCUS       KCXD01004137             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:21147:21380
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004137
VERSION     KCXD01004137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:21147:21380"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62619.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       424..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          146 c          139 g          104 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctcc agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggttc agtctggggc tgaggtgaag aagcctgggg cctcactgaa
      181 ggtctcctgc aaggtttccg gatccacctt cagcgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aggtgttgct cctctatatg gtgaaatgat
      301 gcacgcagac aacttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga cgacacggcc gtgtatttct gtgcgcgcgg
      421 gcctattaca atttttggcg tccttattac ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004138             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13128:14381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004138
VERSION     KCXD01004138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13128:14381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62620.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       411..420
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          144 c          136 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggct
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cctcagagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcggt agttactggt ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggaa atagcggtag tacctactac agcccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccacctctcc ctgaagctga actctgtgac
      361 caccgcggac acggccgtgt atttctgtgc gaacgtctta ggcccctggg gcagctggtc
      421 acactacttt gagtactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004139             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11505:15225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004139
VERSION     KCXD01004139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11505:15225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62621.1"
                     /translation="CSRGSNYEDAYDYFSAFDSW"
     D_segment       415..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          109 a          135 c          140 g          107 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctatg ccatcaattg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg tataacaaac tacgtacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcatagcc tacatggagc
      361 tgagcggcct aagatctgag gacacggccg tgtattactg ttcgagaggg tcaaattacg
      421 aggatgctta cgattacttt tctgcctttg actcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004140             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18536:7256
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004140
VERSION     KCXD01004140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18536:7256"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62622.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           93 a          137 c          130 g          107 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cagtagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattactgtg tgagatatga ggatgaatcc attaactacc
      421 actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004141             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20343:13603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004141
VERSION     KCXD01004141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20343:13603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62623.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       433..439
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          100 a          124 c          161 g          115 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagttcg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggtttcag cttcagtttc tactatatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtggat ttcaggtatt gacactggag
      301 ggggtgacac ctactatgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaagac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag agtagtgggt ggtgccgccg gatacttcga cttctggggc cagggcgccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004142             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20764:7481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004142
VERSION     KCXD01004142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20764:7481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..496
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62624.1"
                     /translation="CARVLYYDSGYSTNPYNRFDVW"
     D_segment       415..433
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          141 c          141 g          105 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgacca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggcttctg gatacacctt caccatctat gccatcactt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg aggaatcatc cctcttgttg gcataacaaa cgacgcacag
      301 aagttccagg gcagagtcac gcttaccgcg gacacgtcca caagcacagc ctacatggag
      361 ctgagcagcc tgagatctga ggacacggcc gtgtattatt gtgcgagagt tttatactat
      421 gatagtggtt attccacgaa cccctacaac cggttcgatg tctggggtcc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004143             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9147:9207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004143
VERSION     KCXD01004143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9147:9207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62625.1"
                     /translation="CARGSNVWVPDFDYW"
     D_segment       429..436
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          117 a          133 c          144 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagcgtc accgaattat gcatacactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgtaaatga ggcaataata
      301 gacgctgaga acttccaggg cagactcacc atgaccgagg acacgtctac tgacacagcc
      361 tacatggagc tgaggagcct gagatctgag gacacggccg tgtattattg tgccagaggg
      421 agcaacgtgt gggtaccgga ctttgactac tggggccagg gagtcctggt caccgtctct
      481 tcagcc
//
LOCUS       KCXD01004144             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19446:15954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004144
VERSION     KCXD01004144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19446:15954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62626.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          107 a          146 c          134 g           92 t
ORIGIN      
        1 acatgggggc atcacacaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcag gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctgtatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac ttggaactga
      361 gcggcctgac ttctgaggac acggccgtgt attactgtgc gactggccct accggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004145             294 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22057:5311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004145
VERSION     KCXD01004145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 294)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 294)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22057:5311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..292
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..292
     V_segment       6..230
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <223..>261
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62627.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       237..248
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       249..292
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        293..>294
                     /gene="IGHG"
BASE COUNT           60 a           84 c           85 g           65 t
ORIGIN      
        1 atgggtgtct ctggtggctc tatcagtatt tactactgga attggatccg ccaggcccca
       61 gggaagggac tggactggat tggacatatc tatggtagcg gtggtagcac caactacaac
      121 ccctccctca agagtcgagt caccctgtca gtagacacgt ccaagaacca gttctccctg
      181 aacctgaggt ctgtgaccgc cgcggacacg gccgtatatt actgtgcgag cggtcggcgg
      241 cagctggact ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004146             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9186:8290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004146
VERSION     KCXD01004146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9186:8290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62628.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          106 a          109 c          153 g          123 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcaccct cagtaactat ggcatacact
      241 gggtccgcca ggctccaggg gaggggctgg agtgggtggc agttatatcg tatgatggaa
      301 gtaagaaata ttacgcagac tctgtgaagg accgattcac catttccagt gacagttcca
      361 agaacatggc atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtgtattatt
      421 gtgtgagaga tgcgtttggt tccggtttgg attcctgggg cctgggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004147             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15388:3482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004147
VERSION     KCXD01004147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15388:3482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62629.1"
                     /translation="CARGYCSGSFCSSAFDYW"
     D_segment       429..439
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          120 a          129 c          146 g          103 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtcaggg gctgagatga agaagcctgg ggcctcagtg
      181 aaggtctctt gcaaggtttc cggaaacacc ttcagcgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaaggcct tgagtggatg ggaggtgttg aacctggata tggtgaaata
      301 atatatgcag agaagttcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agttgagcag cctgagatct gaggatacgg ccgtttatta ctgtgcgagg
      421 ggatactgta gtggtagttt ctgttcgtca gcctttgatt actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004148             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18313:6894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004148
VERSION     KCXD01004148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18313:6894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62630.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          108 a          140 c          154 g          104 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 tctctgaggt ccaactggtg cagtctgggg ctgaggtgag gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggttgg gaggtgttga tcctgcaaat ggtgaggtaa
      301 tacacgcaga tagttttcag ggcagagtca ccatgaccga ggacacgtct acactcacag
      361 cctacatgga gctgagcggc ctgagatctg aggacacggc cgtgtattac tgtgcgagag
      421 ggcggttcgg tagcagcgtc tggtccaatc tcgtctatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004149             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15424:6624
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004149
VERSION     KCXD01004149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15424:6624"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62631.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          103 a          126 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gtttgccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcaacctc tggattcagt ttcagttact actacatggg
      241 ctgggtccgc caggctccag ggaagggtct ggaatggatc tcaggtatta acagtggtgg
      301 ggataccaca tactatgcgg actccctgaa gggcagattc accatctcca gagacaacgc
      361 caagaacaca ctgtctcttc aaatggacgg cctgagagct gaggactcgg cagtctatta
      421 ctgtgcgcga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004150             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20469:2484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004150
VERSION     KCXD01004150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20469:2484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..415
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62632.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       426..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           98 a          143 c          133 g          111 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggagcag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagctttt ccagttactg gatcacctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatggggg cgattgatcc tagtgattct actaccaaat
      301 acagcccgtc cttccaaggc caggtcacca tttcagtcga caagtccatc accaccgcct
      361 acctggagtg gagcagcctg aaggcctcgg acaccgccac gtattactgt gcgaagggtc
      421 ccggagtgat tattaactac tttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004151             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7898:10211
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004151
VERSION     KCXD01004151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7898:10211"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62633.1"
                     /translation="CARDEGEISGYRFGYW"
     D_segment       453..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          113 a          111 c          162 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtggt gtctggagga ggcttggttc
      181 agcctggggg gtccctgaaa ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcatc atctctagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gagattggag gacacggcca
      421 tgtattactg tgcgagggat gagggggaga ttagtgggta ccgatttggc tactggggcc
      481 agggagtccg ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004152             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19129:12414
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004152
VERSION     KCXD01004152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19129:12414"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62634.1"
                     /translation="CARGLGSSAHFGLDAW"
     D_segment       423..430
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          103 a          141 c          146 g           97 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga tgtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag gcctctggat tcgccttcaa catgtatgcc ctcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gatcgtccct ctccttggaa caacaaactc
      301 cgcacagaag ttccagggca gagtcacgat taccgcggac acgtccataa gtacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cgagaggcct
      421 gggcagcagc gcccactttg gtttggatgc ctggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01004153             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12218:10587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004153
VERSION     KCXD01004153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12218:10587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..472
     V_segment       106..397
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62635.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       403..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          140 c          131 g          111 t
ORIGIN      
        1 acatggggct gtctgagagt cagggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagg tcccagatgg gtcctgtccc agccgcagct gcagttgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcgcctg cgttgtctct
      181 ggtggctcca tcagcgatta ctcctggagc tggatccgcc agcccccagg gaagggactg
      241 gagtggattg ggaatattga tgttcatctt gcgggcccca actacaaccc ctccctcaag
      301 agtcgagtcg ccatttcaaa agacacgtcc aagaatcagt tctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtatatttc tgtgcgaaac aatatagtgg tagttattac
      421 tattcccact ttgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004154             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13350:2409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004154
VERSION     KCXD01004154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13350:2409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62636.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       426..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          107 a          139 c          152 g          103 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgccctctct
      121 gaggtccaac tggtgcagtc tggggctgag gtgaggaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggaga caccttcacc gatttatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gttgggaggt gttgatcctg caaatggtga ggtaatacac
      301 gcagatagtt ttcagggcag agtcaccatg accgaggaca cgtctacact cacagcctac
      361 atggagctga gcggcctgag atctgaggac acggccgtgt attactgtgc gagagggcgg
      421 ttcggtagca gcgtctggtc caatctcgtc tatggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004155             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21598:14568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004155
VERSION     KCXD01004155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21598:14568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62637.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       438..444
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          114 c          147 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaattgg tggagtctgg aggaggtttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagttt ctggattcac cttcagtaac tatgccatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ctaacaacat gctatatctt caaatgagca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag gcgcccttgg aacgctgact actttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004156             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19434:18849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004156
VERSION     KCXD01004156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19434:18849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62638.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       408..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           94 a          137 c          136 g          105 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcaacttct actggaactg gatccgccag accccaggga aggggctgga
      241 gtggattggg tgtatcagtg gtgatagtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtcaac atttcgacag acaggtccaa gaaacagttc tccctgaaga tgagttctat
      361 gaccgccgcg gacacggccg tatattactg tgcgagagac ccccggtggc agctggaact
      421 tctcttcttt gactattggg gcccgggagt cctggttacc gtctcctcag cc
//
LOCUS       KCXD01004157             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16833:7689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004157
VERSION     KCXD01004157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16833:7689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62639.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          112 a          142 c          132 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga aatgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgcgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01004158             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20808:12874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004158
VERSION     KCXD01004158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20808:12874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62640.1"
                     /translation="CARSRGVLLPYFDYW"
     D_segment       401..406
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           90 a          136 c          134 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtatctact ggagctggtt ccgccagccc ccagggaagg gactggaatg
      241 gattgggcgt atctctggtg atagtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa gcagttctcc ctgaagatgg aatctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagaagtagg ggggtgcttc tcccctactt
      421 tgactactgg ggccagggag tcctggtcac cgtttcctca gcc
//
LOCUS       KCXD01004159             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20541:9305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004159
VERSION     KCXD01004159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20541:9305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62641.1"
                     /translation="CVRGMDNYHYVNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          116 c          149 g          131 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgtttctat
      121 attaaaaggt gtccagtgtg tggagcatct ggtggagtct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct catgtgtagc ctctgaattc accttcagtg gctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctggagtgg gtttcaggtg ttaacattgg
      301 cgatgaccca ttctacccag actctgtgaa gggtcgattc accatctcca gagacaatgc
      361 caagaactcc ttgtatcttc aaatgaacaa cctgagagct gaggacactg ctgtgtatta
      421 ttgtgtgagg gggatggata actaccacta cgttaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004160             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23838:12086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004160
VERSION     KCXD01004160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23838:12086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62642.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       439..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          113 c          157 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aataaatact acgcagactc tgtgaaggcc cgattcaccg tctccagaga
      361 caattccaag aacatgttat atcttcaaat ggacaacctg aaattggaag acacggccgt
      421 gtattactgc gcgagagatg tctgggggag gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004161             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9065:21628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004161
VERSION     KCXD01004161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9065:21628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62643.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       399..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           98 a          136 c          138 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
      121 gggcccagga ctgatgaagc cttcagagac cctgtccctc agctgcgctg tctctggtgg
      181 ctccataagt ggtaactggt ggagctggat ccgccagccc ccagggaagg gactggactg
      241 gattggacgt atctctggta ctagtgggga caccaattac aatccctccc tcacgagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga actctgtgac
      361 cgccgcggac gcggccgtgt attattgtgc aagagcggat tacgaggatg attacggtta
      421 tcatttagga tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01004162             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13430:4668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004162
VERSION     KCXD01004162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13430:4668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62644.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       439..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          121 c          146 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaggtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggttca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatcttca atacctatgc
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgca
      301 tgatggaact aagacatact acacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacattcaat atcttcacat gaacaacctg aaattggagg atacggccat
      421 atactactgt gcggcctcct acttggggta cggatttgag tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004163             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11181:17652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004163
VERSION     KCXD01004163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11181:17652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62645.1"
                     /translation="CARSPSGSWLYWYFDFW"
     D_segment       424..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          144 c          135 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccat
      121 actgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaatttt ccatgcactg gctacgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtttttgg tgaaatgata
      301 cacgcagaga agttccagaa cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgcgatca
      421 cccagcggca gctggctata ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004164             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16754:3683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004164
VERSION     KCXD01004164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16754:3683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62646.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       268..276
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           74 a           78 c           88 g           80 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
       61 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      121 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      181 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      241 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004165             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:10395:19974
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004165
VERSION     KCXD01004165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:10395:19974"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..519
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62647.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       448..454
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..519
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          118 a          125 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagcact gaacacaaga gactcaccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcaggctct ggattcacct tcagtgacta
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaaatct tacaattacg cgacagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaaga acaccctaca tctgcaaatg agcagcctga aaatcgagga
      421 cacggccgtg tattactgtg ctagagggga tataccggct atagaggcct actacggttt
      481 ggattcctgg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004166             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8965:5390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004166
VERSION     KCXD01004166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8965:5390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62648.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       419..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          141 c          131 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtaaag gagcctgggg cctcagtaaa
      181 ggtctcctgc aaggtttccg gattcacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 acacacagag ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctaa gatctgagga cacggccctg tattactgtg cagtcggcta
      421 tagcggcaga tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004167             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7228:3248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004167
VERSION     KCXD01004167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7228:3248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62649.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          119 a          143 c          145 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctgggg cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 acacgcagag aaattccagg gcagagtcac catgaccgag gacacgtctg cagacacagc
      361 cttcatggag ttgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaacct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004168             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21875:4727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004168
VERSION     KCXD01004168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21875:4727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..493
     V_segment       118..417
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62650.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       420..426
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          119 c          148 g          117 t
ORIGIN      
        1 acatggggga ttcccaggcg tctccacttg gtgatcagca ctgaacacaa gagactcacc
       61 atggagtttg cactgagctg ggttttcgtt gttgctactt taaaaggtgt ccagtgtgag
      121 gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gcgggtccct gagactctcc
      181 tgtgcaggct ctggattcac cttcagtgac tatgccatga gctgggtccg ccaggcttct
      241 gggaaaggac tggagtgggt tggctatatt agaagcaaat cttacaatta cgcgacagaa
      301 tacgccgcat cggtgaaagg caggttcacc atctccagag atgattcaaa gtacacgcta
      361 catctgcaaa tgagcagcct gaaaaccgag gacacggccg tgtattactg tgctagaggg
      421 gatataccgg ctatagaggc ctactacggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004169             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21960:9933
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004169
VERSION     KCXD01004169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21960:9933"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62651.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       268..274
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           79 a           78 c           89 g           76 t
ORIGIN      
        1 acatgggggg gggtccctga cactctcctg tgcagcctct ggattcacct tcagtagcta
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtga cagttatatc
      121 gtatgatgaa agtaagaaat actacgcaga ctttttgaag gaccgattca ccatttccag
      181 agacaattcc aagaacacgc tatatcttca aatgaacaac ctccaattgg aggacacggc
      241 cgtgtattac tgtgcgagag atgataatgg ggtgcttatc gacttctggg gccagggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004170             531 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23252:13297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004170
VERSION     KCXD01004170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 531)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 531)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23252:13297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    154..527
                     /note="immunoglobulin heavy chain variable region"
     V_region        154..527
     V_segment       154..453
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <445..>498
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62652.1"
                     /translation="CARTSYGGSYYFFYFDYW"
     D_segment       464..478
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       483..527
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        528..>531
                     /gene="IGHG"
BASE COUNT          120 a          130 c          148 g          133 t
ORIGIN      
        1 acatggggga ccctgcagct ctgggagagg agacccagcc ttgggattcc caggcgtctc
       61 cacttggtga tcagcactga acacaagaga ctcaccatgg agtttgtact gagctgggtt
      121 ttccttgttg ctattttaaa aggtgtccag tgtgaggtgc tactggtgga gtctggggga
      181 ggcttggtcc agcctggcgg gtccctgaga ctctcctgtg cagcctctgg attcaccttc
      241 agtgactatg ccatgagctg ggtccgccag acttctggga aaggactgga gtgggttggc
      301 tatattagaa gcaaatctaa taattacgcg acagaatacg ccgcatcggt gaaaggcagg
      361 ttcaccatct ccagagatga ttcaaagaac acgctatatc tacaaatgac cagcctgaaa
      421 accgaggaca cggccgtgta ttactgtgct agaacttcct atggtggtag ttattacttc
      481 ttctactttg actactgggg ccagggagtc ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01004171             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22531:4006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004171
VERSION     KCXD01004171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22531:4006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..498
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62653.1"
                     /translation="CARGWNAVTVEAVYGLNSW"
     D_segment       422..429
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          137 c          151 g           99 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt gcagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg taaggcttct ggatacccct tcgacaacta tggtatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagcgatcat cccccttgtt gacataacag
      301 actacgcaga gaagttccgg ggcagagtca cgattaccgc ggacacgtcc acaaacacag
      361 cctacatgga gctgcgcagc ctgagatctg aggacacggc cgtgtattat tgcgcgagag
      421 gctggaatgc agtaactgtg gaggctgtct acggtttgaa ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004172             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18432:7938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004172
VERSION     KCXD01004172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18432:7938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62654.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       412..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          114 a          141 c          128 g           91 t
ORIGIN      
        1 acatgggaca caaccaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggct cctcctcttg gtggcagcag ctacaggcgc ccactccgag
      121 gtccagctgg tacagtctgg ggctgaggtg aagaagcctg gggcctccgt gaaaatctcc
      181 tgccaggctt ctggatacac cttaaccgac cactacctac actgggtgcg acaggctcct
      241 gggaaaggac ttgagtggat gggaggtgtt catcctgaat atggaaaagt agactacaca
      301 cagaagttcc aagacagagt caccatcacc gcggacatgt cgacagagac agtctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtttatt actgtgtgac agtgggtccc
      421 taccattact ttgacttctg gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004173             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14983:11711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004173
VERSION     KCXD01004173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14983:11711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62655.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          112 a          141 c          150 g          102 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccct
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgagg aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggttggg aggtgttgat cctgcaaatg gtgaggaaat
      301 acacgcagat agttttcagg gcagagtcac catgaccgag gacacgtcta cactcacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 gcaattcggt accagcgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004174             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21569:13716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004174
VERSION     KCXD01004174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21569:13716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62656.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT          117 a          139 c          132 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg ctacaccttc gccgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggttttgcta gtatatatgg tgaaataata
      301 catagagaga gattccaggg cagagtcacc atgacagcgg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gacatctgag gacacggccg tgtattattg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctccgcc
//
LOCUS       KCXD01004175             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7269:21143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004175
VERSION     KCXD01004175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7269:21143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..480
     V_segment       99..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <384..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62657.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       397..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..480
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT           99 a          134 c          137 g          112 t
ORIGIN      
        1 acatggggtc tctgagagtc acggacatcc tgtgcgagaa catgaagtat ctgtggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca gctgcagttg caggagtcgg
      121 gcccaggact gatgaagcct tcagagaccc tgtccctcag ctgcgctgtc tctggtggct
      181 ccataagtgg taactggtgg agctggatcc gccagccccc agggaaggga ctggactgga
      241 ttggacgtat ctctggtact agtggggaca ccaattacaa tccctccctc aagagtcgag
      301 tcaccatttc aacagacacg tccaagaacc acttctccct gaagctgaac tctgtgaccg
      361 ccgcggacgc ggccgtgtat tattgtgcaa gagcggatta cgaggatgat tacggttatc
      421 atttaggata caactggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01004176             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15520:19007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004176
VERSION     KCXD01004176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15520:19007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62658.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       400..408
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          136 c          139 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctctggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatga gcagtcacta ctgcagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac ggatctctgg tagtggtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tctcaacaga cacgtccaag aaggagatct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagaag actatggtgg taattattat
      421 tttaaccggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004177             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22042:12105
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004177
VERSION     KCXD01004177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22042:12105"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62659.1"
                     /translation="CVKDSYGRGFDSW"
     D_segment       438..445
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          112 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcctg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac catggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttatg tcgaatgatg
      301 gaagtaagaa atattacgca gactctgtga aggaccgatt taccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccatatatt
      421 cctgtgtgaa ggattcttac ggtagaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004178             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9984:4102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004178
VERSION     KCXD01004178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9984:4102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62660.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       429..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          119 a          143 c          135 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggc ccagctggtg cagtctgggg cggaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacatct tcaccgaatt atcgttccac tgggtgcgcc
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 tacacacaga gaaattccag ggcagaatca ccatgaccga ggacacgtcc acagacacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgatat
      421 catccagtgg cagctggcta ttctggtatt tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004179             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14506:14131
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004179
VERSION     KCXD01004179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14506:14131"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..520
     V_segment       139..432
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <424..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62661.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       442..448
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..520
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          111 a          116 c          159 g          136 t
ORIGIN      
        1 acatgggggg agaggagcca cagccccggg attcccagct gtctccactt ggtcatgaac
       61 actgaactca gaagacgcac catggagttt gtgctgagtt tgcttttcct tgttgttttt
      121 ttaaaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt ggtaaagcct
      181 ggggggtccc tgagactctc ttgtgtagtc tctggattct ccttcagtaa ctatgttatg
      241 cattgggtcc gccaggctcc aggaaagggt ctggagtggg tctcacttat tagtggaagt
      301 ggtggtacca cagactacgc agactctgtg aagggccgat tcaccctctc cagagacaac
      361 gccaaggaat cgctttttct gcaaatgaac agcctaagag ccgaggacac ggccgtgtat
      421 tactgtgcta gaggcgggga aatagtggat tcagagatta ttgaggatta ctacggtttg
      481 gatttctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004180             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15359:13834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004180
VERSION     KCXD01004180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15359:13834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..463
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62662.1"
                     /translation="CARDPQWQLELLFFDYW"
     D_segment       408..417
                     /gene="IGHD1-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>469
                     /gene="IGHG"
BASE COUNT           89 a          141 c          136 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcggc aattcccact ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggcat atcagtggtg atagtgggaa taccgactac aatccctccc tcaagagtcg
      301 agtcacgatt tcaacagaca cgtccaagaa tcagttctct ctggagttga cttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagacccc cagtggcaac tggaactcct
      421 cttctttgac tactggggcc agggagtcct ggtcaccgtc tccgcagcc
//
LOCUS       KCXD01004181             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21834:9854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004181
VERSION     KCXD01004181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21834:9854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62663.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       416..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          140 c          130 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtaaaggag cctggggcct cagtaaaggt
      181 ctcctgcaag gtttccggat tcaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaaaca
      301 cacagagttc catgccagat tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttgagc agcctaagat ctgaggacac ggccctgtat tactgtgcag tcggctatag
      421 cggcagatgg aacaactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01004182             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18748:7787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004182
VERSION     KCXD01004182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18748:7787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..467
     V_segment       116..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62664.1"
                     /translation="CASGSRRQPDKW"
     D_segment       418..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..467
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          139 c          145 g           95 t
ORIGIN      
        1 acatgggcag agtacatggg gatgctctct gagagtcacg gacctcctgt gcaagagcat
       61 gaagcacctg tggttcttcc tcctcctggt ggtagctccc agatgggtcc tgtcccaggt
      121 gcagctgcag gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg
      181 cgctgtctct ggtggctcca tcagcggtta ctggtggggc tggatccgcc agcccccagg
      241 gaaggggctg gagtggattg gatatatcgg tggaactagt gggagcacct actacaaccc
      301 ctccctcaag agccgagtca ccatttcaac agacacgtcc aagaaccagg tctccctgaa
      361 gttgatcact gtgaccgccg cggacacggc cgtgtattac tgtgcgagtg gaagtcggcg
      421 gcagccggat aaatggggcc agggcctcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004183             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12252:16996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004183
VERSION     KCXD01004183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12252:16996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62665.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       426..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          121 a          147 c          141 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagcc accggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagttaa gaagcctggg gcctcagtga
      181 tggtctcctg ccaggtttcc ggatacaccg tcaccgaaat ttccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttgc tcctgaaaaa aatgagttaa
      301 tacacgcaga caagttccag gacagattca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtggc ctgacatctg aggacacggc cgtgtattac tgtgcgaccc
      421 acggagggta tagcgacatc tggaactccc tatatcacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004184             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:8986:18288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004184
VERSION     KCXD01004184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:8986:18288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62666.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          118 c          150 g          116 t
ORIGIN      
        1 acaggggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 agactaagaa atactacgca gactctgtga agggccgatt caccatctcc agagacaatt
      361 ccaaaaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004185             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7187:14292
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004185
VERSION     KCXD01004185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7187:14292"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62667.1"
                     /translation="CASGFSGRWILWYFEIW"
     D_segment       423..431
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          141 c          139 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggccctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctgggaca gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtatatgg cgaaatgata
      301 gacgcagaga agttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaacagcct gagatctgag gacacggccg tgtattattg tgcgagcggc
      421 tttagcggca ggtggatcct ctggtatttc gaaatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004186             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15510:13475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004186
VERSION     KCXD01004186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15510:13475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62668.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       423..432
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          119 a          142 c          127 g          101 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat ccctgcactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agttttaatc ctatttatgg tgaaatttta
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gatatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt atccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01004187             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14863:5223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004187
VERSION     KCXD01004187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14863:5223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62669.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       435..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          144 c          153 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 gctctgaggt ccacctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg gaaagggctt gagtggatgg gagttgttga tcctgtcaat ggtgaagaaa
      301 tatacgcagg gaggttccag ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga cttgaccagt ctcagatctg aggacacggc catctattac tgtgcgacag
      421 ggaggatcgg tagtagcggc tggtccagcc tcttcaccgg tttggattcc tggggccgag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004188             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:8447:10477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004188
VERSION     KCXD01004188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:8447:10477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62670.1"
                     /translation="CARTTSRGLVFDFW"
     D_segment       397..401
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           87 a          138 c          134 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc agttactggt ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggta atagcgggag caccaactac aatccgtccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgaacctga cctctgtgac
      361 cgccgcggac acggccgcct atttctgtgc gaggaccacc tcccgggggc ttgtttttga
      421 tttctggggc caagggctca gggtcaccgt ctcttcagcc
//
LOCUS       KCXD01004189             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22111:13679
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004189
VERSION     KCXD01004189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22111:13679"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62671.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       452..466
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          114 a          126 c          148 g          131 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattt ccagctgtct ccacttggtg
       61 atcagcactg aacacaggag actcgccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgactat
      241 gccctgagct gggtccgcca ggcttctggg aaaggactgg agtggattgg ctatattaga
      301 agccaatata acaatttcgc gacagaatac gccccatcgg tgaaaggcag attcgccatc
      361 tccagagatg attcaaagaa cacgctattt ctgcaaatga gtagcctgaa aaccgaggac
      421 acggccgtgt attactgcac cacccatttt ggtggtaatt attacttgga ctactttgtc
      481 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004190             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12210:12903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004190
VERSION     KCXD01004190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12210:12903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62672.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       434..446
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          108 c          154 g          117 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc agccgggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt ttgatgaaag
      301 taagaaatac tatgcagact ctgtgaagga ccgattcacc gtctccagag acaattccaa
      361 gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg tgtattactg
      421 tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01004191             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13234:12395
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004191
VERSION     KCXD01004191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13234:12395"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62673.1"
                     /translation="CAGRTWSGGTPLLDYW"
     D_segment       426..433
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          135 c          134 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctggaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ttctccatca gcagtgacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatatatgg aagaagtggg agcatctact ataatccctc cctcaacagt
      301 cgagtcacct tttcaacaga cacgtccaag aaccagttct ccttgaagct gaactctgtg
      361 accgccgcag acgcggccgt ttattactgt gcggggcgga cctggagtgg tggcacgccc
      421 ctccttgatt attggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004192             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13926:12267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004192
VERSION     KCXD01004192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13926:12267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62674.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           94 a          139 c          130 g          100 t
ORIGIN      
        1 acatggggga ggttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggcgccatc agcagtggtt tctactggac ctggatccgc caacccccag gaaaggggct
      241 ggagtggatt gggtgtatcg gaggtaatag tggtaccacc tactacaacc cctccctcaa
      301 gagtcgagcc accatttcaa aagacacgtc caacaatcaa ctctccctga agctgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004193             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18036:12547
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004193
VERSION     KCXD01004193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18036:12547"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62675.1"
                     /translation="CAIGPSGRWNGWSFDIW"
     D_segment       414..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          146 c          137 g           90 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccctc accgaagtgt ccactcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctaa gatctgagga cacggccgtg tattactgtg cgattggccc ttccggcagg
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01004194             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:24478:17576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004194
VERSION     KCXD01004194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:24478:17576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62676.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          109 a          120 c          156 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttatt actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtgtta atagtggtgg
      301 ggaaagcaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctatatcttc aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004195             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21915:13473
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004195
VERSION     KCXD01004195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21915:13473"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62677.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       441..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          112 c          160 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgttattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcccg
      181 gggggtcact gagactgtcc tgtgcagcct ctggattcac cttcagtagc tctggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggaatggga ggcacttata tctaatgatg
      301 gaagtaagaa atattacgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctgtatctt caaatgaaca acctgaaatt ggatgacacg gccgtgtatt
      421 actgtgcgcg agttggagag ggtagtggtg gtgcggagga ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004196             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5199:12264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004196
VERSION     KCXD01004196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5199:12264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62678.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          111 c          159 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcagctt cagtatcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa gtaagaaata ctacacagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaaaatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattatt gcgcgagaga cgattttggc agcggcttag ggtactgggg ccagggagcc
      481 ctggtgaccg tctcttcagc c
//
LOCUS       KCXD01004197             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:3866:9710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004197
VERSION     KCXD01004197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:3866:9710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62679.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       443..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          117 c          153 g          114 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcggccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttttggcatc
      241 cactgggtcc gccaggctcc agggaagggc ctggagtggg tggcagttat atcgtctgat
      301 gaaagtaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaagt tggaggacac ggccgtctat
      421 tactgtgcga gagacgcata tggcagcggc tgtgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004198             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:10722:7205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004198
VERSION     KCXD01004198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:10722:7205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62680.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       452..467
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          117 c          157 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtggccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctga gttcaccttc agtggctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtggca cttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gagattggag gacacggccg
      421 tgtattactg tgcgagagtg gggacatatg atagtggtta ttacaccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004199             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:8445:9991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004199
VERSION     KCXD01004199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:8445:9991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..489
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62681.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          121 a          143 c          133 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc gaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg aatggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctcc gcc
//
LOCUS       KCXD01004200             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20538:5584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004200
VERSION     KCXD01004200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20538:5584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62682.1"
                     /translation="CARTSGGWSPYFDFW"
     D_segment       401..416
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           90 a          142 c          132 g          103 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtacc tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg acgtatctct ggtggtggtg ggaacaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaga gacacgtcca ggaaccactt ttccctgcag ctgaattatg
      361 taaccgccgc ggacacggcc gtgtattact gtgccagaac tagcggtggc tggtccccct
      421 actttgactt ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004201             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20705:14318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004201
VERSION     KCXD01004201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20705:14318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62683.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       418..429
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          139 c          137 g           95 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aagaaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga gatctgagga cacggccgtc tattactgtg cgattggccc tagtggcagc
      421 tggaacgact ggtccttcga catttgggga cctggcaccc caatcaccgt ctcctcagcc
//
LOCUS       KCXD01004202             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13505:3027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004202
VERSION     KCXD01004202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13505:3027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..493
     V_segment       145..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62684.1"
                     /translation="CARSWGRWSAEYVDFW"
     D_segment       436..441
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>507
                     /gene="IGHG"
BASE COUNT          107 a          116 c          160 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aagacacagg agtcaccatg gagtatctgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagcaggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag agtctcctgt gcagcctctg atttcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aggggtctgg agtgggtatc aggtattagc
      301 attggcggga ccacatacta cccagactct gtgaagggtc gattcatcgt ctccagagac
      361 aataccgaga agtccttgta tcttcaaatg aacagcctga gaactgagga cactgctgta
      421 tatttttgtg caagatcgtg gggcaggtgg tcagcggaat acgtcgactt ctggggccag
      481 ggcgcccttg tcagtgtctc cgcagcc
//
LOCUS       KCXD01004203             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9444:5687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004203
VERSION     KCXD01004203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9444:5687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..356
     V_segment       7..295
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <287..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62685.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       299..305
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       314..356
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           86 a           84 c          101 g           87 t
ORIGIN      
        1 acatgggcaa ctggtggaat ctggaggagg cttggttcaa cctggggggt ccctgagact
       61 ctcctgtgca gcctctggat tcaccttcag taactttggc atacactggg tccgccaggc
      121 tccagggaag gggctggagt gggtggcagt tatttcgtct gatggaagta acaaatacta
      181 cgcaaactct gtgaagagcc gattcagcat ctccagagac aattccaaga acatacttta
      241 tcttcaaatg aacaacttga aattggagga cacggccgtc tattactgtg cgagagatga
      301 tattgggacc ggttttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004204             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21228:11025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004204
VERSION     KCXD01004204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21228:11025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..459
     V_segment       108..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62686.1"
                     /translation="CASNSITSGPDYW"
     D_segment       403..409
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           89 a          141 c          129 g          102 t
ORIGIN      
        1 acatggggaa atgttctctg agaggcacgg acatcctgtg caagaacatg aggcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccgcctg cagctgcagg
      121 cggcgggccc aggactggtg aagccttcgg agaccctgtc tctcacctgc gctgtctctg
      181 gtggctctat cagcggtaac tactggagct ggatccgccg ggccccaggg aagggactgg
      241 agtggattgg atatatctac ggtagtgatt ttaccaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagca gatacgtcca agaaccagct ctccctgaac ctggcctctg
      361 tgaccgccgc ggacacggcc gtctatttct gtgccagtaa tagtataaca tctggtccag
      421 attactgggg ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004205             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:26417:10241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004205
VERSION     KCXD01004205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:26417:10241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62687.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          146 c          132 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gttttgatcc tgtatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 gcagcctgac atctgaggac acggccgtct attactgtgc gattggccct agcggcagct
      421 ggaaccactg gtccttcgat atctggggcc cctgcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004206             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:4881:7801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004206
VERSION     KCXD01004206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:4881:7801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..498
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62688.1"
                     /translation="CARGPITIFGVLITGLDSW"
     D_segment       425..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          145 c          142 g          102 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatccacct tcaccgagtt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttgc tcctctatat ggtgaaatga
      301 tgcacgcaga caacttccag ggcagagtca ccttgaccga ggacacgtct acagacacag
      361 cctacatgga gctgaacagc ctgagatctg acgacacggc cgtctattac tgtgcgcgcg
      421 ggcctattac aatttttggc gtacttatta cggggcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004207             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21897:5680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004207
VERSION     KCXD01004207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21897:5680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62689.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          114 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaac taagaaatac tacgcagact ctgtgaaggc ccgattcacc gtctccaaag
      361 acaattccaa gaacatgtta tatcttcaaa tggacaacct gaaattggaa gacacggccg
      421 tgtattactg cgcgagagat gtctggggga ggggatttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004208             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22741:7288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004208
VERSION     KCXD01004208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22741:7288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62690.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           96 t
ORIGIN      
        1 acatgggtga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01004209             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11990:20305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004209
VERSION     KCXD01004209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11990:20305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62691.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          115 c          149 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aattggtgga gtctggagga actttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtaattatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatgtaag taggacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattctaa gaacatggta tatcttcaaa tgatcagcct gaaattggag gacacggccg
      421 tgtatttctg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004210             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13729:4844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004210
VERSION     KCXD01004210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13729:4844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62692.1"
                     /translation="CAIGPSGNWNGWSFDVW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          104 a          139 c          140 g           96 t
ORIGIN      
        1 acatggggga tccaacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaactgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatggtgt
      301 tccagggcag agtcaccatg accgaggaca cgtctataga cacagcctat atggagttga
      361 gcagcctgag atctgaggac acggccgtgt attactgcgc gattggccct agcggcaact
      421 ggaacggctg gtccttcgat gtctggggac ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004211             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19457:6668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004211
VERSION     KCXD01004211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19457:6668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62693.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          140 c          150 g           97 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gaaatgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gacagggagg
      421 ttcgggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004212             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24781:4453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004212
VERSION     KCXD01004212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24781:4453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..255
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62694.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       261..267
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           78 a           84 c           86 g           73 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcatgtt caatacctat
       61 gccatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      121 catgatggaa ctaagacata ctacacagac tctgtgaagg accgattcac catctccaga
      181 gacaattcca agaacataca atatcttcac atgaacaacc tgaaattgga ggacacggcc
      241 atatactact gtgcggcctc ctacttgggg tacggatttg agtactgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004213             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8929:22179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004213
VERSION     KCXD01004213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8929:22179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..406
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62695.1"
                     /translation="CASPLLPTTGNW"
     D_segment       422..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           91 a          134 c          136 g          106 t
ORIGIN      
        1 acatggggga tgggaaatgc tctctgagag tcatggacat cctgtgcaag aacatgaagc
       61 acctgtggtt cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc
      121 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgatg
      181 tctctggtca ctccatcaat agtggttact cctggggctg gatccgtcag cccccaggga
      241 agggactgga gtggattggg tttatcggtg gtcgtagtgg gtacacctac tacaacccct
      301 ccctcaggag tcgagtcagc atctcaaaag acacgtccaa gaaccagttc tccctggaag
      361 tgagttctct gagcgccgcg gacacggccg tgtattattg tgcgagtcct ctccttccga
      421 caactggaaa ctggggccag ggagtcctgg tcatcgtctc ctcagcc
//
LOCUS       KCXD01004214             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17364:6134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004214
VERSION     KCXD01004214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17364:6134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..447
     V_segment       93..389
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62696.1"
                     /translation="CARWSAANFDYW"
     D_segment       394..400
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           91 a          129 c          135 g           94 t
ORIGIN      
        1 acatggggag agtcacggac ctcctgggca agaacatgag gcatctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtccc tcacctgcga tgtctctggg ggctccatca
      181 gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg gagtggattg
      241 ggtgtatcta cgatagtagt ggaaacacct actacaaccc ctccctcaag agtcgagtca
      301 ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gatgaggtct atgaccgccg
      361 cggacgcggc cgtgtattat tgtgcgagat ggtcggcagc caactttgac tactggggcc
      421 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004215             425 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7977:15539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004215
VERSION     KCXD01004215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7977:15539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..423
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..423
     V_segment       63..356
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>392
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62697.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       358..364
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       377..423
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        424..>425
                     /gene="IGHG"
BASE COUNT           79 a          103 c          141 g          102 t
ORIGIN      
        1 acatggggga gttcgtgctg agctgggttt tccttgttgc tcttttgaaa ggtgtccagt
       61 gtgaggtgca gctggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
      121 tctcctgcgc agcctctggt ttcagcttca gtttctacta tatgacctgg gtccgccagg
      181 ctccagggaa ggggctggag tggatttcag gtattgacac tggagggggt gacacctact
      241 atgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag aagacactgt
      301 atcttcaaat ggacagcctg agagctgagg acacggctgt ctattactgt gcgagagtag
      361 tgggtggtgc cgccggatac ttcgacttct ggggccaggg cgccctggtc accgtctcct
      421 cagcc
//
LOCUS       KCXD01004216             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17952:3804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004216
VERSION     KCXD01004216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17952:3804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62698.1"
                     /translation="CARDAYGRGFDSW"
     D_segment       445..452
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          114 c          153 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcccgggg ggtccctgag actctcctgt gcagcctctg gatacacctt cagtaatttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc agttatatcg
      301 tatgatgaag ataagaatta ccacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 ttctattatt gtgcgagaga tgcttacggt agggggtttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004217             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21474:14195
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004217
VERSION     KCXD01004217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21474:14195"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62699.1"
                     /translation="CARGRYNWKGVLVDFW"
     D_segment       400..412
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           92 a          136 c          135 g          104 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct gctggtggca gctcccagat gtgtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccgtcag caataactac tggacttgga tccgccagcc cccagggaag gggctggaat
      241 ggattggccg tatctatggt cgtattggga acaccgacta caacccctcc ctcaacagtc
      301 gagtcgccat ttcaacagac acgtccaaga accagttctc cctgaagctc agctctgtga
      361 cggccgcgga cacggccgtt tattactgtg cgagaggccg gtataactgg aaaggtgtct
      421 tagtggattt ctggggccaa gggctcaggg tcgccgtctc ttcagcc
//
LOCUS       KCXD01004218             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16911:13581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004218
VERSION     KCXD01004218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16911:13581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62700.1"
                     /translation="CAREYCTTTDCAGFFDFW"
     D_segment       417..427
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          131 c          143 g          105 t
ORIGIN      
        1 acatggggac acaaaacaac cacatccctc ctctaaagaa gcccctggga gcacagctca
       61 tcaccatgga ctggacctgg aggctcctct ttgtggtggc agcagctaca ggtgtccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tttcctgcaa ggcttctgga ttcaccttcg acaactatgg aatcaactgg gtgcggcagg
      241 cccctggaca agggcttgag tggatgggag tgaccatccc ccttgttggt attgtaaatt
      301 atgcagagaa gttccagggc agagtcacga ttaacgcgga cacgtccaca aacacagcct
      361 tcatggaggt gaggagcctg agatctgagg acacggccat ttatttctgt gcgagagaat
      421 actgtacaac tacagattgc gccggcttct ttgacttctg gggccaggga gccatggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004219             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17250:4238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004219
VERSION     KCXD01004219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17250:4238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62701.1"
                     /translation="CTRYGGDRGDWYFDYW"
     D_segment       407..413
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           90 a          135 c          137 g           97 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 agcagtagct actggagctg ggtccgccag cccccaggga aggggctgga ctggattggg
      241 tatatctatg gtggtagtgg gagcaccggc tacaacccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaaac tgaactctct gaccgccgcg
      361 gacaccgccg tgtattactg cacgagatat gggggagatc ggggcgactg gtactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004220             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:6984:13221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004220
VERSION     KCXD01004220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:6984:13221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..491
     V_segment       144..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62702.1"
                     /translation="CTGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          111 a          130 c          151 g          105 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agatggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga atgggtctca gctattaata
      301 ctgatgggga gaacacatac tacgcagact ccgtgaaggg ccgattctcc atctccagag
      361 acaactcaaa gaccacactc tccctgcaaa tgaacagcct gagaccggag gacacggccg
      421 tatattactg tacgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc cacagcc
//
LOCUS       KCXD01004221             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15997:6824
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004221
VERSION     KCXD01004221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15997:6824"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62703.1"
                     /translation="CARDSDSREFSFDYW"
     D_segment       451..455
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          122 c          144 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggttca cctgctggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggac tgggtggcag ttatatcgta
      301 tgatggaagt aagaaatact acgcatactc tgtgaatgac cgattcacca tctccagaga
      361 caattccaac aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatt ccgactcccg agaattcagt tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004222             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19822:18826
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004222
VERSION     KCXD01004222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19822:18826"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62704.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          144 c          134 g           91 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctgcaga cacagcctac atggacctga
      361 gtagcctgac atctgaggac acggccgtgt attactgtgc gactggccct agcggcacct
      421 ggaacgcctg gtacctcgat atctggggcc caggcactcc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004223             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15865:14370
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004223
VERSION     KCXD01004223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15865:14370"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..489
     V_segment       120..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62705.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       427..442
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          111 a          140 c          141 g           99 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aagtccagct ggtgcagtct ggggctgaag tgaggaggcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggagac accttcaccg aattatccgt gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg gtgggaggtg ttcatcctct atatggtaaa ataacacacg
      301 cagagaactt ccaggacaga gtcatcatga ccgaggacac gtcgacagac acagcctaca
      361 tggagctgag cagcctgaca tctgaggaca cggccgtcta ttactgtgcg agaggatttt
      421 gtcatggtac ttattgctcc tcgggtcttg tctcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004224             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13516:17913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004224
VERSION     KCXD01004224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13516:17913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..509
     V_segment       146..439
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62706.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       445..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          109 a          121 c          161 g          120 t
ORIGIN      
        1 acatggggga gctctgagag aggagcctta gccctggatt tcaaggcact tccacctggg
       61 gatcagcact gaacacagag gacccaccat ggagttgggg ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc ggtgtgaggt gcagttggtg gagtctgggg gaggcttggt
      181 ccagcctgga gggtctctga gactctcctg tgtagcctct ggattcagct tcagaagtta
      241 cgaaatgagt tgggtccgcc aggctccggg aaaggggctg gagtgggtct catatattag
      301 tcacactggt gaaaccatat accacgctga ctccgtgaag ggccgattca ccatctccag
      361 agacaacgcc aagaattcgc tgtctctgca aatgagcagc ctgagagccg aggacacggc
      421 cgtgtattac tgtactagga accggaatac tgtaatgatt gggtggttcg atgtctgggg
      481 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004225             348 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19753:11361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004225
VERSION     KCXD01004225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 348)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 348)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19753:11361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..344
     V_segment       7..254
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <250..>315
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62707.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       266..291
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..344
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>348
                     /gene="IGHG"
BASE COUNT           84 a           92 c           98 g           74 t
ORIGIN      
        1 acatgggggg cctcagtgaa gctctcctgc aaggcttctg ggttcacctt tagcaccgaa
       61 gccatcaatt gggtgcgaca ggcccctgga caaggacttg actggatggg aggggtcatc
      121 cctcttatgg gtacaacaaa ctacgcacag aagttccagg gcagagtcac gtttaccgcg
      181 gacacgtcca taagcacagc ctacatggag ctgagcagcc tgagatctga ggacacggcc
      241 gtgtattatt gtgccaaatc cgtgaattac gaggaagata acggttacta tataccgacg
      301 cagtttgact actggggcca gggagtcctg gtcaccgtct cctctgcc
//
LOCUS       KCXD01004226             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19159:14663
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004226
VERSION     KCXD01004226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19159:14663"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62708.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       433..439
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          139 c          149 g          101 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg ccctctctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaggaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggt tgggaggtgt tgatcctgca aatggtgagg aaatacacgc
      301 agatagtttt cagggcagag tcaccatgac cgaggacacg tctacactca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gagggcaatt
      421 cggtaccagc gtctggtcca atctcgtcta tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004227             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5466:8708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004227
VERSION     KCXD01004227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5466:8708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62709.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           99 a          145 c          134 g          108 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01004228             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16887:19174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004228
VERSION     KCXD01004228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16887:19174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62710.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       399..414
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           87 a          145 c          133 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtaccta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tggtggtggg aacaccgact acaacccctc cctcaagagc
      301 cgagtctcca tttcaagaga cacgtccacg aaccagttct ccctgcagct cgactatgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagaacta gcggtggctg gtccccctac
      421 tttgactatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004229             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18596:6604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004229
VERSION     KCXD01004229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18596:6604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62711.1"
                     /translation="CATGPSGSWNDWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          117 a          145 c          138 g           92 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gtcatctgag gacacggccg tgtattactg tgcgactggc
      421 cctagcggca gctggaacga ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01004230             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12797:13277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004230
VERSION     KCXD01004230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12797:13277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62712.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       449..458
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          124 a          117 c          152 g          127 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcaatgagta
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtggattg gctatattag
      301 aagcaaatat aacgattacg cgacagaata tgccgcatcg gtgaaaggca gattcaccat
      361 ctccagagat gattcaaaga acacactata tctgcagatg agcagcctga aaaccgagga
      421 gacggccgta tattactgca cccgtctcta tagtgggaac tatagaatta tgatgtttga
      481 ctactggggc cagggagtcc tggtcagtgt ctcctcagcc
//
LOCUS       KCXD01004231             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:2696:9939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004231
VERSION     KCXD01004231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:2696:9939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    19..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        19..373
     V_segment       19..315
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <307..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62713.1"
                     /translation="CARWSAANFDSW"
     D_segment       320..326
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       329..373
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           70 a          110 c          115 g           80 t
ORIGIN      
        1 acatgggggg tcctgtccca ggtgcaactg caggagtcgg gcccaggact ggtgaagcct
       61 tcggagaccc tgtccctcac ctgcgctgtc tctggtggct ccatccgcag tggttatggc
      121 tggagctgga tccgccagtc cccagggaag gggctggagt ggattggatg tgtctatgat
      181 agtagtggga acacctacta caacccctcc ctcaagagtc gagtcaccat ttcaatggac
      241 acgtccaaga accagttctc cctggagctg aggtctatga ccgccgcgga cacggccgtg
      301 tatcactgtg cgagatggtc ggcagccaac tttgactcct ggggtcaggg agtcctggtc
      361 accgtctcct cagcc
//
LOCUS       KCXD01004232             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8747:4765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004232
VERSION     KCXD01004232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8747:4765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62714.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          114 c          152 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aagacaagag atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01004233             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23816:16304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004233
VERSION     KCXD01004233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23816:16304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62715.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       459..466
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          111 a          135 c          157 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga gacttggtcc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggcggtgg taggatatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacagcct gagacctgag gacacggccg
      421 tatattactg tgcgtcgaac ctacgtggaa acacctacac ttactggcgg tcctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004234             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20888:16362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004234
VERSION     KCXD01004234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20888:16362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..522
     V_segment       153..444
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <438..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62716.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       449..463
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..522
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT           97 a          161 c          143 g          123 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg ccgaggtgca gctggtgcag tctggagcag
      181 aggtgaagag gcccggggaa tctctgagga tctcctgtca gacttctgga tacagttttg
      241 ccaactactg gatcgcctgg gtgcgccaga tgcccgggaa aggcctggag tggatgggga
      301 tcatctatcc tggtgattct gacaccaagt acggcccgtc cttcgaaggc caggtcacca
      361 tctcagccga caagtccacc agcaccgcct acctgcagtg gagcagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagactct ggggtgatta ttacgcactc cagtactact
      481 tcgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004235             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8534:13349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004235
VERSION     KCXD01004235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8534:13349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..498
     V_segment       135..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62717.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       438..444
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          155 g          120 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 aaaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg aagctggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actttcctgc gcagcctctg gattcagctt caattattac tacatgagct
      241 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaat agtggtgggg
      301 aaagtacgta ctatgcagag tccgtgaggg gcagattcac catctccaga gagaacgcca
      361 agaacacact atttcttcaa atggacagcc tgagaactga ggacacggct gtctattact
      421 gtgtgagaga tcgacgtgta cagtcgttat cctggttcga tgtctggggc ccgggagccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004236             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:24907:15685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004236
VERSION     KCXD01004236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:24907:15685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    72..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        72..426
     V_segment       72..368
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62718.1"
                     /translation="CARWSAANFDSW"
     D_segment       373..379
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       382..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           81 a          127 c          128 g           92 t
ORIGIN      
        1 acatggggga gaacatgaag catctgtggt tcttcctcct cctggtggca gctcccagat
       61 gggtcctgtc ccaggtgcaa ctgcaggagt cgggcccagg actggtgaag ccttcggaga
      121 ccctgtccct cacctgcgct gtctctggtg gctccatcaa cagtggttat ggctggagct
      181 gggtccgcca gcccccaggg aaggggctgg agtggattgg gtgtctctat gatagtagtg
      241 ggaacacgta ctacaacccc tccctcaaga gtcgcgtcac catttcaaaa gacacgtcca
      301 agaaccagtt ctccctgagc ctgaggtcta tgaccgccgc ggacacggcc gtgtattact
      361 gtgcgagatg gtcggcagcc aactttgact cctggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01004237             317 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14619:12911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004237
VERSION     KCXD01004237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 317)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 317)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14619:12911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..315
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..315
     V_segment       7..236
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <228..>284
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62719.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       243..260
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       265..315
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        316..>317
                     /gene="IGHG"
BASE COUNT           70 a           85 c           89 g           73 t
ORIGIN      
        1 acatgggcgg tgtctctggt ggctccttca gcggtttcta ttggagctgg atccgccagt
       61 ccccagggaa gggactggag tggattgggt atatcagtgc tagtagtggg agtaccgact
      121 acaacccctc cctcaagagt cgagtcacca tttcaacaga cacgtccaat aaccagttct
      181 ccctgaagct gacctctgtg accgccgcgg acacggccgt gtattactgt gcgagagaga
      241 aatactatag tggtagttat aaacacaact ggttcgatgt ctggggcccg ggagtccagg
      301 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004238             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11468:6762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004238
VERSION     KCXD01004238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11468:6762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62720.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          138 c          128 g          107 t
ORIGIN      
        1 gcatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga caggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgttt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004239             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10723:11585
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004239
VERSION     KCXD01004239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10723:11585"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62721.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       428..435
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          104 a          142 c          145 g          100 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgatgtgaa gaagcctggg gcctcagtga
      181 agctctcctg caaggcttct ggattcgcct tcagaatgta tgccctcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggctgg gagggatcgt ccctcttgtt ggaacaacaa
      301 actccgcaca gaagttccag gacagagtca cgattaccgc ggacacgtcc acaagcacag
      361 tctacatgga gctgagcagc ctgagatctg acgacacggc cgtgtattac tgtgcgagag
      421 gcctgggtag cagcgcccac tttggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004240             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15919:19245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004240
VERSION     KCXD01004240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15919:19245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..477
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62722.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       419..434
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          109 a          107 c          142 g          121 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc cctgagactc tcctgtgcag
      181 cctctggatt caccttcagt ggctatggca tgcactgggt ccgccaggct ccagggaagg
      241 ggctggaatg ggtggcactt atctcgtatg atggaagtaa gaaatcctac gcagactctg
      301 tgaaggaccg attcaccatc tccagagaca attccaagaa catcctatat cttcaaatga
      361 acaacctgaa attggaggac acggccatgt atttctgtgc gagagtgggg acatatgata
      421 gtggttatta cacctttgac tattggggcc agggagtcct ggtcaccgtc tcctcagtc
//
LOCUS       KCXD01004241             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:9579:19241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004241
VERSION     KCXD01004241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:9579:19241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62723.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       441..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          114 a          112 c          159 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa gtaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacaggct atatcttcaa atgaacaacc tgaaattgga ggacacggca
      421 gtgtattact gtgcgagaga tgatagtggg gtgatcatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01004242             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15920:13560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004242
VERSION     KCXD01004242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15920:13560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62724.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       435..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          106 a          125 c          159 g          127 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtctg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agctttggcg atcatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcaa tcagtaatac
      301 tggtaaagcc gtacactacg ctgactccgt gaagggccga ttcaccattt ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttattgttgt agcgattact atagtggtag ttattactat tggggctacg gcttggattc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004243             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:8061:7887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004243
VERSION     KCXD01004243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:8061:7887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62725.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           97 a          135 c          137 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgag gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccttca gcggtttcta ttggagctgg atccgccagt ccccagggaa gggactggag
      241 tggattgggt atatcagtgc tagtagtggg agtaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaat aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagaga aatactatag tggtagttat
      421 aaacacaact ggttcgatgt ctggggcccg ggagtccagg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004244             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:7356:21566
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004244
VERSION     KCXD01004244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:7356:21566"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..457
     V_segment       105..390
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62726.1"
                     /translation="CMGGKRQLDLDYW"
     D_segment       407..413
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           91 a          133 c          128 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccggctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtttctggt
      181 gactctatca gcacttactt ctggaactgg atccgccagg ccccagggat gcgactggag
      241 tggattggat ttatctatgg ttatgatagt agtaccaact ataacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaac aaccaactct ccctgaggct gacctctgtg
      361 accgccgcgg acacggccgt gtattactgt atgggcggga agaggcaact ggatcttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004245             273 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:6047:12347
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004245
VERSION     KCXD01004245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 273)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 273)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:6047:12347"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..271
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..271
     V_segment       12..210
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <202..>240
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62727.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       221..225
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       229..271
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        272..>273
                     /gene="IGHG"
BASE COUNT           61 a           80 c           73 g           59 t
ORIGIN      
        1 acatggggtt tctactggac ctggatccgc caacccccag ggaaggggct ggagtggatt
       61 gggtgtatcg gtggtaatag tggtaccacc tactacaacc cctccctcaa gagtcgagcc
      121 accatttcaa aagacacgtc caacaatcaa ctctccctga aggtgagttc tgtgaccgcc
      181 gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt tgactactgg
      241 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004246             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8972:11313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004246
VERSION     KCXD01004246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8972:11313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62728.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       444..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          122 c          156 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggtaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttatttct
      241 acatgagctg ggtccgtcag gctccaggga aggggctgga gtggatctca agtattgaca
      301 gtggtgggac taccacaaat tatgcagact ccgtgaggga cagcttcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagccgag gacacggctg
      421 tctattattg tgcgagagcg cgcggggtga ttattacata ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004247             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17734:14728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004247
VERSION     KCXD01004247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17734:14728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62729.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       423..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          109 a          145 c          140 g          104 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca agcttttcgg atccaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aggggcttga atggatggga ggtgttgctc ctctttatgg tgaaatgatg
      301 cacgcagaca acttccaggg cagagtcacc ttgaccgagg acccgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgac gacacggccg tgtattactg tgcgcgtggg
      421 cctattacaa tttttggcgt acttattacg gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004248             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14832:8465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004248
VERSION     KCXD01004248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14832:8465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62730.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          122 c          155 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcaa gtattaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagagg
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004249             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12752:7305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004249
VERSION     KCXD01004249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12752:7305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62731.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          122 c          145 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gaactgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaag ctctcctgtg cagcctctga gttcaccttc agtgactatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccaagaa ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004250             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21030:16719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004250
VERSION     KCXD01004250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21030:16719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62732.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       446..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          114 c          150 g          123 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgcg
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcaa
      181 ccggaggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tttctatggc
      241 ttgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatttcgaat
      301 gatgaaaata acaaatacta cgcagactct gtgaaggacc gattcaccat ttctagagac
      361 aattccatga acatgctatt tcttcaaatg aacaacctga acttggacga cacggccgtc
      421 tattactgtg tgagagatga tttaggcagc ggcttagggt cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004251             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:9316:12337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004251
VERSION     KCXD01004251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:9316:12337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62733.1"
                     /translation="CATGRMGSSGWSNLFTGLESW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          144 c          146 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa ggccttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatgggtagc agcggctggt ccaacctctt cactggtttg gaatcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004252             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11665:15947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004252
VERSION     KCXD01004252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11665:15947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62734.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          154 g          118 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattattg tgcgagagga gactacggta acagccttga cttctggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01004253             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:8767:17342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004253
VERSION     KCXD01004253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:8767:17342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62735.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       452..463
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          120 a          126 c          151 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccagttggc
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgactt
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aaccaaatat aacaattacg cggcagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaaga acacgatata tctgcaaatg agtagcctga aaaccgagga
      421 cacggccgtg tatttctgca ccacatggag atattactat agtactggtt accccacctt
      481 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004254             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13194:18504
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004254
VERSION     KCXD01004254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13194:18504"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62736.1"
                     /translation="CAGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          126 c          154 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aaatggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gctcttaatt
      301 atgatgggga tagtacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgcacagcct gagagaggat gacacggccg
      421 tatatttctg tgcgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004255             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:24353:10416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004255
VERSION     KCXD01004255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:24353:10416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62737.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          120 c          156 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcacaaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc aggttcaatt attactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttagtagtgg
      301 tggggaaagc acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactatatc ttcaaatgga cagcctgaga actgaggaca cggctgtcta
      421 tttctgtgtg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01004256             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14633:15970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004256
VERSION     KCXD01004256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14633:15970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62738.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          111 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg cgcgagagac gattttggca gcggcttagg gtactggggc cagggagccc
      481 tggtgaccgt ctcttcagcc
//
LOCUS       KCXD01004257             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8936:3416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004257
VERSION     KCXD01004257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8936:3416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62739.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          146 c          132 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgac cctgcatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatccga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004258             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:18546:10874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004258
VERSION     KCXD01004258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:18546:10874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..315
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..315
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62740.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       259..267
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..315
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        316..>319
                     /gene="IGHG"
BASE COUNT           80 a           75 c           92 g           72 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      121 tgatggaact aagaagtact acggagactc tgtgaaagac cgattcacca tttccagaga
      181 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      241 atattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      301 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01004259             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18747:13374
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004259
VERSION     KCXD01004259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18747:13374"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62741.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       448..453
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          154 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag agcacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct
      241 ggcatgcact gggtccgcca gactccaggg aaggggctgg agtgggtggc agttaaatcg
      301 tttgatggaa ctaagatata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga agacacggcc
      421 gtttattact gtgtgaggga tgcctacggg agcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004260             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12931:4458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004260
VERSION     KCXD01004260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12931:4458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62742.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          122 c          158 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtctcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004261             364 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:9554:14272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004261
VERSION     KCXD01004261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 364)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 364)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:9554:14272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..362
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..362
     V_segment       128..292
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <284..>331
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62743.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       297..310
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..362
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        363..>364
                     /gene="IGHG"
BASE COUNT           73 a           98 c          110 g           83 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggactata ttggctatat cagtggtagt agtgggagca cctactacaa
      181 gccctccctc atgagtcgag tcatcatttc aagagacacg tcccggaatg agttctccct
      241 gaggctgagg tctgtgactg tcgcggacac ggccgtgtat tattgtgcga gacgagatag
      301 ctggaacaac ggggggagcc ttgactactg gggccaggga ttcctggtca ccgtctcctc
      361 agcc
//
LOCUS       KCXD01004262             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21885:14795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004262
VERSION     KCXD01004262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21885:14795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..472
     V_segment       109..402
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62744.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       417..427
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          137 c          133 g          112 t
ORIGIN      
        1 acatgggggg ggaaatgctc tctgagagtc atggacctcc tgtgcaagaa catgaagcac
       61 ctgtggttct tccttctcct ggtggcaact cccagatggg tcctgtccca ggtgcagctg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcac ctgcgctgtc
      181 tctggtgact ccatcggcaa tagctactgg atctggatcc gccagccccc agggaagggg
      241 ctggagtgga tagggtctat ctatggtagt actgggagca ccttttacga cccctccctc
      301 aagggtcgag tcaccgtttc aacagacacg tccaagaacc tattttccct gactctggac
      361 tctgtgaccg ccgcggacac cgccgtgtat tactgtgcga gatatagcga tactgatagt
      421 tattacttct ttgactactg gggccaggga gtccgggtca ccgtctcctc agcc
//
LOCUS       KCXD01004263             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14261:15512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004263
VERSION     KCXD01004263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14261:15512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62745.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          140 c          132 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggttaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaat ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 cttggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004264             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20215:13336
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004264
VERSION     KCXD01004264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20215:13336"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62746.1"
                     /translation="CAIGPSGRWNGWSFDIW"
     D_segment       415..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          107 a          146 c          138 g           90 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccct caccgaagtg tccactcact gggtgcgaca
      241 ggcccccgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtccaca gacacagcct acatggaact
      361 gagcagccta agatctgagg acacggccgt gtattactgt gcgattggcc cttccggcag
      421 gtggaacggc tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01004265             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:7373:4655
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004265
VERSION     KCXD01004265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:7373:4655"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62747.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       446..452
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgccgact ctttgaaaga ccgattcacc atatccagag
      361 acgactccag gaacatgcta tatcttcaac tgaacaacct gaaattggac gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct gggggcttga ctactggggc cagggagtcc
      481 tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01004266             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6458:11004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004266
VERSION     KCXD01004266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6458:11004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..341
     V_segment       7..283
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <275..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62748.1"
                     /translation="CARWSAANFDSW"
     D_segment       288..294
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           66 a          103 c          102 g           72 t
ORIGIN      
        1 acatgggggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc
       61 tggtggctcc atcaacagtg gttatggctg gagctgggtc cgccagcccc cagggaaggg
      121 gctggagtgg attgggtgtc tctatgatag tagtgggaac acgtactaca acccctccct
      181 caagagtcgc gtcaccattt caaaagacac gtccaagaac cagttctccc tgagcctgag
      241 gtctatgacc gccgcggaca cggccgtgta ttactgtgcg agatggtcgg cagccaactt
      301 tgactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004267             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12482:11187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004267
VERSION     KCXD01004267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12482:11187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62749.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 agactaagaa atactacgca gactctgtga agggccgatt caccatcttc agagacaatt
      361 ccaaaaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004268             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13836:10720
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004268
VERSION     KCXD01004268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13836:10720"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..476
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62750.1"
                     /translation="CTKTYYSGSLEYW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>479
                     /gene="IGHG"
BASE COUNT          103 a          147 c          124 g          105 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggaacag aggtgaaaag gcccggggag tctctgagga
      181 tctcctgtca gacctctgga tacaactttc ccagcagctg gatcacctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatgggga ccatctatcc tgctgattct aatgccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctcagtcga caagtccatc agcaccacct
      361 acttgcagtg gagcaacctg aaggcctcgg acaccgccac gtattactgt accaaaacct
      421 actatagtgg tagtttggaa tactggggcc agggagtcct ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01004269             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23118:10025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004269
VERSION     KCXD01004269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23118:10025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62751.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       443..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          118 a          112 c          148 g          115 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctgtttt
      121 aagaggtgtc cagtgtgagg tacagctggt ggagtctgga ggagacttgg ttcagccggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact atggcataca
      241 ctggatccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtctgatgg
      301 aagtaagaca tactacgcaa actctgtgaa ggaccgattc accatattaa gagacaattc
      361 caagaacatg ctctatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gacgatatgg gaagtggctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004270             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8897:4150
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004270
VERSION     KCXD01004270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8897:4150"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62752.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       402..412
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          138 c          139 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcggt gtctctggtg
      181 gctccatcag cagtaactac tggagctgga tccgccagtc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtggtggga gcaccgtcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagatctc cctgaaagtg acctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgacagccgg atatagcagc agtgaaagct
      421 tctacggttt ggattcgtgg ggccaagggg tcgtcgtctc cgtctcctca gcc
//
LOCUS       KCXD01004271             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21638:14899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004271
VERSION     KCXD01004271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21638:14899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62753.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          120 c          155 g          126 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtagtagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004272             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:4775:14843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004272
VERSION     KCXD01004272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:4775:14843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..326
     V_segment       4..256
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <248..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62754.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       266..276
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       285..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           74 a           92 c           88 g           74 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtac agccactgga ttcaccttca gtagttttgg
       61 catgagctgg gtccgccagc ctccagggaa ggggctggag tgggtctcat acattagtaa
      121 tagtggtagt agcacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      181 caactcaaag aacacgctct ccctgcaaat gaacagcctg acagctgagg acacggccgt
      241 gtatcactgt gcgaaacatc gtttcagcag ctggtcgtat ttccttgact tctggggcca
      301 gggaatcctg gtcgccgtct cctcagcc
//
LOCUS       KCXD01004273             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7432:12596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004273
VERSION     KCXD01004273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7432:12596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62755.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       412..422
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          107 a          144 c          133 g           91 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 agtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgagggtctc
      181 ctgcaggatt tccggataca ccttcaccga attatccata cactgggtgc ggcaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctctg tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacttgg aactgagcgg
      361 cctgacttct gaggacacgg ccgtgtatta ctgtgcgact ggccctaccg gcacctggaa
      421 cgcctggtac ctcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01004274             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18702:2994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004274
VERSION     KCXD01004274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18702:2994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62756.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       262..268
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           76 a           79 c           88 g           78 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaatttt
       61 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      121 tctgatggaa gtcacaaata ctacgccaac tctgtgaaga gccgattcgc catctccaga
      181 gacaattcca agaacatact atatcttcaa atgaacaact tgaaattgga ggacacggcc
      241 gtctattact gtgcgagaga tgatattggg accggttttg actactgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004275             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12117:13187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004275
VERSION     KCXD01004275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12117:13187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62757.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       310..318
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       319..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           78 a           84 c          116 g           84 t
ORIGIN      
        1 acatgggggt gcagctggtg gagtctggag gaggcttggt tcagccgggg gggtccctgg
       61 ggctctcctg tgcagcctct ggattcacct tcagtcacta tggcgttcac tgggtccgcc
      121 aggctccagg gaaggggctg gagtgggtgg cagttatatc gtatgatgaa aataagaaat
      181 actacgcaga ctctgtgagg gaccgattca ccatctccag agacaattcc aagaccatgg
      241 tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtatttc tgtgtgagag
      301 atgtcagagg cggtggcttt gactactggg gccagggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01004276             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:27226:11971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004276
VERSION     KCXD01004276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:27226:11971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62758.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          133 c          137 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattggct atatatatgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtgga cacgtccaag aaccagtgct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtatttttgt gcgagttcgg gtatagaagt ggttgcgtac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004277             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13803:13924
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004277
VERSION     KCXD01004277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13803:13924"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..489
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62759.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       433..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT           98 a          147 c          132 g          114 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aaaccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gcatatcagt gggagtagtg ggagcaccga ctacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaca gacacgtcca agagccactt ctccctgaaa ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga gctttccccc tacgactatt
      421 tttggagtga tttttactct tactactttg actacttggg ccagggactc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004278             366 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21806:5904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004278
VERSION     KCXD01004278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 366)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 366)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21806:5904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..364
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..364
     V_segment       74..294
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <286..>333
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62760.1"
                     /translation="CARYELFGNQYNFDYW"
     D_segment       299..305
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       320..364
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        365..>366
                     /gene="IGHG"
BASE COUNT           85 a          104 c           91 g           86 t
ORIGIN      
        1 acatggggaa agctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg ctccatcaac aataactact ggacctggat ccgccagccc
      121 ccagggaagg gactggaatg gattggatat atctatggtg gttctgggag caccacctac
      181 aacccctccc tcaagagtcg agtcaccatt tcaacagaca cgtccaggaa cctgttttcc
      241 ctgaacctga gttctgtgac cgccgcggac accgccgtgt attactgtgc gagatatgag
      301 ttatttggga accaatacaa ctttgactac tggggccagg gagtcctggt caccgtctcc
      361 tcagcc
//
LOCUS       KCXD01004279             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10308:16152
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004279
VERSION     KCXD01004279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10308:16152"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62761.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       411..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          138 c          145 g          107 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt tactgtactg
      421 gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004280             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6546:17206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004280
VERSION     KCXD01004280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6546:17206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..458
     V_segment       83..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62762.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       387..403
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..458
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           99 a          140 c          117 g          104 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcac cttctctggg ttctcaatca gtacttctgc
      181 aacaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaagcat
      241 ttattggaat gatactaaat tcttcagcac ttcgctgaag agcagactca ccgtctccaa
      301 ggacacctcc aaaacccagg tggttctaac aatagccaac atggaccctg tggacacagc
      361 cacatattac tgtgcacgga tacagggtgg tagttactac tacggtgggg gatacttcga
      421 gttctggggc cagggcgccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004281             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15739:8764
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004281
VERSION     KCXD01004281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15739:8764"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62763.1"
                     /translation="CARWSAANFDLW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           93 a          134 c          134 g          100 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctggg caagaacatg aggcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 ggggctccat caacagtggt tatggctgga gctggatccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtatc tatgatagta gtggaaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca aaagacacgt ccaagaacca gttctccctg aatctgaggt
      361 ctatgaccgc cgcggacacg gccgtgtatt actgtgcgag atggtcggca gccaactttg
      421 acctctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004282             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21293:6595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004282
VERSION     KCXD01004282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21293:6595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62764.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       428..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          141 c          139 g          103 t
ORIGIN      
        1 acatggggac tctcaacaac tgcatccaac ctcaagagaa gcccctgaga gcacagtttc
       61 tcaccatgga cttgacctgg aagatcctcc tcttggtgac agcagccaca ggtgcccact
      121 cccaggtgca actggtgcag tctgggggtg agattaagca gcctggggcc tcagtgaagc
      181 tctcctgtca ggcttctgga tattccctca ctcactactt catgcactgg gtgagacagg
      241 cccctggaca gggccttgag tggataggac tgatcacccc tcacaatgat cataaagtct
      301 acgcacagaa cttccagggc agagtcacca taactacgga cacgtccacg agcacagtgt
      361 ccatggagct gagcagcctg agatccgaag acacagccgt atactactgt gcgagagggg
      421 gggacataga atattgtact ggtagtggtt gtggggagct tgactcctgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004283             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22311:6369
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004283
VERSION     KCXD01004283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22311:6369"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..450
     V_segment       84..380
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62765.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       396..401
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..450
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           88 a          138 c          127 g           99 t
ORIGIN      
        1 acatggggga catcctgtgc aagaacatga agcacctgtg gttcttcctc ctcctggtgg
       61 cagctcccag atgggtcctg tcccaggtgc agctgcaggg gtcgggccca gggctggtga
      121 agccttcgga gaccctgtcc ctcacctgcg ctgtttctgg tgactccatc aacagtggct
      181 actactggag ttggatccgc caacccccag ggagggggct ggagtggatt gggtctatcg
      241 gtggtagtag tggcagcacc tactacaacc cctccctcaa gagtcgagtc accctttcaa
      301 aagacacgtc caggaaccag ttctccctga aactgagctc tgtgaccgcc gcagacacgg
      361 ccgtttatta ctgtgcgaga aaacttccag gtctccaact aaccggtttc gattcctggg
      421 gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004284             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:8921:3068
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004284
VERSION     KCXD01004284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:8921:3068"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62766.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          115 c          152 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcagtttca gcaactctgg
      241 cattcactgg gtccgccagg ctccagggga ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaagt aagacatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatggtac atcttcaaat gaacaccctg aatttggagg acacggccgt
      421 atattactgt gtgagagatt cttacggtag aggctttgac cagtggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004285             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:7925:2130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004285
VERSION     KCXD01004285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:7925:2130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62767.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          106 a          141 c          153 g          104 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggtgttgctc ctgcaaatgg tgaggtaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 cggttcggta gcagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004286             359 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10234:19578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004286
VERSION     KCXD01004286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 359)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10234:19578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..357
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..357
     V_segment       8..287
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>326
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62768.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       291..298
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       313..357
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        358..>359
                     /gene="IGHG"
BASE COUNT           75 a          105 c           99 g           80 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg
       61 ctgtctctgg tgactccatc agcagtagct actggaactg gatccgccag cccccaggga
      121 agggactgga gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct
      181 ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc
      241 tgagttctgt gaccgccgcg gactccgccg tgtattactg tgtgagatat gaggatgaat
      301 ccattaacta ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004287             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10417:11646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004287
VERSION     KCXD01004287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10417:11646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62769.1"
                     /translation="CARGQFGTSVWSNLVYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          111 a          141 c          150 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggtgttgatc ctgcaaatgg tgaggaaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 caattcggta ccagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004288             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11008:9555
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004288
VERSION     KCXD01004288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11008:9555"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62770.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       407..419
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           90 a          144 c          127 g          109 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacgtgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctttggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcaa cgattaccac tggagctgga tccgccagcc ccctgggaag ggactggagt
      241 ggattggaca tatctctcat agtcgtggaa gcaccgacta caacccctcc ctcaagagtc
      301 gcgtcaccat ttcaacagac acgtccaaga accagttctc cctgaagttg agctctgtga
      361 cccccgcgga cacggccgtc tattactgtg cgagagatca ggattcttac gtttactatc
      421 gcttctttga cttctggggc cagggagtcc tggtcgccgt ctcctcagcc
//
LOCUS       KCXD01004289             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13040:14117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004289
VERSION     KCXD01004289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13040:14117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62771.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       440..444
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          118 c          154 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 tctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg agtccctgag actctcctgt gcagcctctg gattcacctt cagtagctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggccgg agtgggtgtc tgtaatttcg
      301 tctgatggaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaactcca agaacatact atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgtgagaga tgccttcggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004290             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20521:14299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004290
VERSION     KCXD01004290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20521:14299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62772.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       404..419
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           95 a          138 c          129 g          105 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggaat
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 gctccatcac caatagctac tggaactgga tccgccagcc cccagggaag gggctggagt
      241 ggattgggtc tatctatggt ggtactggga gcaccggcta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaacctg acctctgtga
      361 ccgccgcgga caccgccatc tattattgtg cgagatatga ggatgaatac agtgactact
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004291             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16050:8558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004291
VERSION     KCXD01004291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16050:8558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62773.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          112 c          154 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc tatggcattc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt gacggttata tcgaatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acgtgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004292             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13064:13998
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004292
VERSION     KCXD01004292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13064:13998"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..378
     V_segment       8..299
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62774.1"
                     /translation="CTRIGFGSLAAAGHYFDYW"
     D_segment       316..329
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       331..378
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           72 a          100 c          118 g           90 t
ORIGIN      
        1 acatgggggt gcagctggtg gagtctgggg gagacttggt ccagcctggg gggtccctga
       61 gactctcctg tgtagcctct ggattcacct ttgctgatta tggcatgcac tgggtccgcc
      121 aggctccggg aaaggggctg gagtgggtct catccattga taggacggct aaaaccgtct
      181 actacgctga ctccgtgagg ggccgattca ccatttccag agacaacgcc aagaactcgc
      241 tgtctctgca aatgagcagc ctgagagccg aggacacggc cgtgtatttt tgtactagaa
      301 ttggctttgg atctctagca gcggctggtc actactttga ctactggggc cagggagtcc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004293             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20590:15799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004293
VERSION     KCXD01004293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20590:15799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..519
     V_segment       144..443
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <435..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62775.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       446..452
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..519
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          116 a          127 c          158 g          120 t
ORIGIN      
        1 acatggggct ctgggagagg agacccagcc ttgggattcc caggcgtctc cacttggtga
       61 tcagcactga acacaagaga caccccatgg agtttgcact gagctgggtt ttcgttgttg
      121 ctactttaaa aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtcc
      181 agcctggcgg gtccctgaga ctctcctgtg caggctctgg attcaccttc agtgactatg
      241 ccatgagctg ggtccgccag gcttctggga aaggactgga gtgggttggc tatattagaa
      301 gcaaatctta caattacgcg acagaatacg ccgcatcggt gaaaggcagg ttcaccatct
      361 ccagagatga ttcaaagtac acgctacatc tgcaaatgag cagcctgaaa accgaggaca
      421 cggccgtgta ttactgtgct agaggggata taccggctat agaggcctac tacggtttgg
      481 attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004294             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11311:11437
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004294
VERSION     KCXD01004294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11311:11437"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..378
     V_segment       24..317
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62776.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       321..333
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       337..378
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           87 a           89 c          116 g           88 t
ORIGIN      
        1 acatgggaag aggagtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
       61 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      121 gcatgcattg ggtccgccag actccaggga aggggctgga gtgggtggca gttatgtcgt
      181 ctgatggaag ttacaactac tacgcagact ctatgaagga ccgattcacc atctccagag
      241 acaattccaa gaacacccta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      301 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004295             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:12507:12229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004295
VERSION     KCXD01004295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:12507:12229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62777.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       449..454
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          117 c          153 g          119 t
ORIGIN      
        1 acatgggggg agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgaactggg ttttccttgt
      121 tgctatttta agaggtgtcc agtgtgacgt gcagctggtg gagtctggag gaggcttggt
      181 tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtacctt
      241 tggcatacac tgggtccgcc aggctccagg gaaggggctg gactgggtgg cagttatttc
      301 gtatgatgaa actaagaaat acttcgcaga ctctgtgagg gaccggttca ccatctccag
      361 agacaattcc aaaaacatgg tatatcttca aatgaacaac ctgaaattgg aggacacggc
      421 cgtatattac tgtgcgagag atgtcagggg aacggggttt gacttctggg gccagggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004296             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19780:7165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004296
VERSION     KCXD01004296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19780:7165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..396
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62778.1"
                     /translation="CATGYSGSWNHWYFDVW"
     D_segment       404..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          114 a          139 c          132 g           90 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga cttatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgaccctgca tatggtgaaa tgaaacacgt
      301 agacagggtc tccatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag
      361 cctgacatct gaggacacgg ccgtgtatta ctgtgcaacc ggatatagtg gcagctggaa
      421 ccactggtac ttcgatgtct ggggccctgg caccccagtc accatctcct cagcc
//
LOCUS       KCXD01004297             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7164:10340
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004297
VERSION     KCXD01004297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7164:10340"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62779.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          112 c          156 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagtg caactggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gtagcctctg gattcagctt cagtggcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttacatcg
      301 tttgatgaaa ctaagaaata ttacgcagac tctgtgaagg accgattcac cgtctccaga
      361 gacaattcca agaacatgct gtattttcaa ttgaacaacc tgaaattgga agacacggcc
      421 gtgtatttct gtgcgagaga tgtctatggc aggggacttg actactgggg cctgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004298             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21101:14042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004298
VERSION     KCXD01004298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21101:14042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62780.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          123 a          139 c          136 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaggtggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004299             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12618:17708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004299
VERSION     KCXD01004299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12618:17708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62781.1"
                     /translation="CARWEAADFDYW"
     D_segment       404..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          131 c          137 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtggttatg gctggagttg gatccgccag gccccaggga agggactgga
      241 gtggattggg actatgtatg gtcatagtgg tagtacccgc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccacttt tccctgacgc tgagctctct
      361 gaccgcctcg gacacggccg tgtattactg tgcgagatgg gaggcagcgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004300             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:5295:9735
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004300
VERSION     KCXD01004300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:5295:9735"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..471
     V_segment       99..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <384..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62782.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       399..416
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           99 a          139 c          133 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcaactg caggagtcgg
      121 gcccaggact ggtgaagcct tcggagaccc tgtccctcac ctgcgctgtc tctggtggct
      181 ccctcagcgg ttactactgg agctggatcc gccagccccc agggaagggg ctggagtgga
      241 ttggatatat cagtgctagt agtggaaaca ccgactacaa cccctccctc aagagtcgag
      301 tcaccatttc aacagacacg cccaagaacc agttctccct gatgctgagc tctgtgaccg
      361 ccgcggacac ggccgtgtat tattgtgcga gagagaaata ctatagtggt agttataaac
      421 acaactggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004301             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:14774:6111
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004301
VERSION     KCXD01004301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:14774:6111"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..493
     V_segment       142..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62783.1"
                     /translation="CANALTGGLDYW"
     D_segment       440..448
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          104 a          125 c          157 g          109 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 accactgaac acagaggact caccatggag tctgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgtaca gcctctggat tcaccttcag tagatactgg
      241 atgaactggg tccgccaggc tccagggaag gggctggagt gggtctcagc tattactagt
      301 ggtggagata gtacgtacta cgcagactcc gtgaagggcc gattcaccat ctccagagac
      361 aactcaaaga acacgctctc cctgcaaatg aacagcctta gagcggagga cacggccgtg
      421 tattactgtg cgaacgcgtt aactgggggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004302             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9681:13605
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004302
VERSION     KCXD01004302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9681:13605"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..345
     V_segment       9..271
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62784.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       277..293
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..345
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           85 a           88 c          102 g           72 t
ORIGIN      
        1 acatgggggt gaagaagcct gggacctcag tgaaggtctc ctgcaaggtt tccggataca
       61 ccttcaccga attatccgtt cattgggtgc gacaggcccc tggaaaaggg cttgagtgga
      121 tgggaagtat tgatcctcta tatggtgaaa tgatacacac agagaagttc cagggcagag
      181 tcaccatgac cgaggacacg tctacagata cagcctacat ggagctgagg agcctgagat
      241 ctgacgacac ggccgtgtat tactgtgcga ggtcggatag cggcagttgg aacggctggt
      301 acctcgatct ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01004303             527 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14756:17772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004303
VERSION     KCXD01004303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14756:17772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..525
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..525
     V_segment       144..436
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>494
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62785.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       451..470
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       483..525
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        526..>527
                     /gene="IGHG"
BASE COUNT          113 a          132 c          155 g          127 t
ORIGIN      
        1 acatgggggc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag tgtgaggtgc aactggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttacg
      241 acatgacctg ggtccgccag gctccgggaa aggggctgga atgggtctca tatattagtt
      301 acactggtaa aaccatatac tactctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgccaa gaactctctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattattg ttctagagcg gcttacgaac atgatgacgg ttactattac gtcggcaggt
      481 tttttgactg ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004304             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7774:8920
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004304
VERSION     KCXD01004304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7774:8920"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62786.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       445..461
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          111 a          119 c          153 g          126 t
ORIGIN      
        1 acatggggtc taggagagga gcccagccct gggattccca ggtgttttca tttgtgatca
       61 gcactgaaca cagaagactc atcatggagt ttggcctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagggt gaggtgcaac tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgtgtag cctctggatt caccctcagt aactactgga
      241 tgtactgggt tcgccaggca ccagggaagg ggctggagtg gatctcagct attaatagtg
      301 ttggtgatag cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 gcgccaagaa cacactatat cttcaaatgg acagcctgag agctgaggac acggctgtct
      421 attactgtgc gagagtaccg ggcctagtgg tatttactgc ttcacttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004305             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13974:13105
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004305
VERSION     KCXD01004305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13974:13105"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..466
     V_segment       112..404
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62787.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       411..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          137 c          133 g          103 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctacaa
      121 ttgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct
      181 gtctctggtg gctctatcaa catttactac tggaattgga tccgccaggc cccagggaag
      241 ggactggact ggattggaca tatctatggt agcggtggta gcaccaacta caacccctcc
      301 ctcaagagtc gagtcaccct gtcagtggac acgtccaaga accacttctc cctgaacctg
      361 aggtctgtga ccgccgcgga cacggccgta tattactgtg cgagcggtcg gcggcagctg
      421 gactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004306             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7515:7030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004306
VERSION     KCXD01004306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7515:7030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62788.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       442..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          111 c          152 g          118 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac gatgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtcgg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcactac ctatggcatc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgacagttat atcgtatgat
      301 gaaacaaaga aatactacgc agactctctg aaggaccgct tcatcatctc cagagacaat
      361 tccaagaata tggtatatct tcaaatgaac aacctgaaat tggaggacac ggccgtatat
      421 tactgtgtga gagatgttag gggaacgggg tttgacttct ggggccaggg tgtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004307             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19910:4146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004307
VERSION     KCXD01004307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19910:4146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..501
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62789.1"
                     /translation="CASPPRYCSGGVCYAAEYFEFW"
     D_segment       424..451
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>505
                     /gene="IGHG"
BASE COUNT          117 a          147 c          143 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggagg tgttgatcct gtatatgatg gaataacaca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaagac acgtcgacag acacagccta
      361 catggaactg agtggcctga gatctgagga cacggccgtg tattactgtg cgagcccccc
      421 cagatattgt agtggtggtg tctgctacgc cgctgaatac ttcgagttct ggggccaggg
      481 cgccctggtc accgtctcct ccgcc
//
LOCUS       KCXD01004308             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18629:11032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004308
VERSION     KCXD01004308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18629:11032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..345
     V_segment       9..257
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62790.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       262..283
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       295..345
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           75 a           97 c           96 g           79 t
ORIGIN      
        1 acatgggaga gaccctgtcc ctcagctgcg ctgtctctgg tggctccata agtggtaact
       61 ggtggagctg gatccgccag ccccccagga agggactgga ctggattgga cgtatctctg
      121 gtactagtgg ggacaccaat tacaatccct ccctcaagag tcgagtcacc atttcaacag
      181 acacgtccaa gaaccacttc tccctgaagc tgaactctgt gaccgccgcg gacgcggccg
      241 tgtattattg tgcaagagcg gattacgagg atgattacgg ttatcattta ggatacaact
      301 ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004309             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22096:8381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004309
VERSION     KCXD01004309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22096:8381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62791.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       438..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          110 c          150 g          117 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctttttta
      121 agaggtgtcc agtgtgaggt gcacctggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgaagcctct ggattcacct tcagtagtta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtatgatgta
      301 agtaagaaat actacgcaga cgctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaacacac tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattac
      421 tgtgggagag atgataatgg ggtgcttatc gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01004310             351 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21294:15905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004310
VERSION     KCXD01004310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 351)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 351)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21294:15905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    11..349
                     /note="immunoglobulin heavy chain variable region"
     V_region        11..349
     V_segment       11..272
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <265..>318
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62792.1"
                     /translation="CARGYCSGSVCSSAFDHW"
     D_segment       276..289
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..349
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        350..>351
                     /gene="IGHG"
BASE COUNT           83 a           79 c          110 g           79 t
ORIGIN      
        1 acatgggaga tgaagaagcc tggggcctca gtgaaggtct cttgcaaggt ttccggaaac
       61 accttcaccg aattatccat tcactgggtg cgacaggccc ctggaaaagg gcttgagtgg
      121 gtgggaggtg ttgaacctgg atatggagaa ataatatatt cagagaagtt ccagggcaga
      181 gtcaccatga ccgaggacac gtctacagac acagcctaca tggagttgcg cagcctgaga
      241 tctgaggata cggccgtgta ttactgtgcg aggggatatt gtagtggtag tgtctgttcg
      301 tcggcctttg accactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004311             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:8803:10629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004311
VERSION     KCXD01004311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:8803:10629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62793.1"
                     /translation="CARWSAANFDLW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           88 a          134 c          134 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggggg
      181 ctccatcaac agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtatctatg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaatc tgaggtctat
      361 gaccgccgcg gacacggccg tgtttttctg tgcgagatgg tcggcagcca actttgacct
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004312             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11278:15202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004312
VERSION     KCXD01004312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11278:15202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62794.1"
                     /translation="CGRDDSGVLIDYW"
     D_segment       410..417
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          104 a          105 c          142 g          114 t
ORIGIN      
        1 acatggggag tgttccattc ggtgaccagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgttggtatt ttaagaggtg tccagtgtga ggtgcagctg
      121 gtggaatctg gaggaggctt ggttcagcct ggggggtccc tgagactctc ctgtgcagcc
      181 tctggattca ccttcagtaa ctttggcatg cactgggtcc gcctggctcc agggaagggg
      241 ctggagtggg tggcagttac atcgtctgat gaaagtaaga aatactacgc agactctgcg
      301 aaggaccgat tcaccatctc cagagacaat tccaagaacc tggtatatct tcaaatgaac
      361 aacctgaaat tggaggacac ggccgtgtat tactgtggga gagatgattc tggggtgctt
      421 atcgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004313             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24999:16997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004313
VERSION     KCXD01004313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24999:16997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..344
     V_segment       8..257
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62795.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       266..286
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..344
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           83 a           91 c          101 g           71 t
ORIGIN      
        1 acatgggggg gcctcagtga tggtctcctg ccaggtttcc ggatacaccg tcaccgaaat
       61 ttccatgcac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaagtgttgc
      121 tcctgaaaaa aatgagttaa tacacgcaga caagttccag gacagagtca ccatgaccga
      181 ggacacgtct acagacacag cctacatgga gctgagtggc ctgacatctg aggacacggc
      241 cgtgtattac tgtgcgaccc acggagggta tagcgacatc tggaactccc tatatcacgg
      301 tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004314             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10631:6754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004314
VERSION     KCXD01004314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10631:6754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62796.1"
                     /translation="CTRDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          105 a          123 c          159 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagtttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaaaa
      301 gtggtgggga tagcacattc tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tctcttcaaa tggacggcct gagagctgag gactcggctg
      421 tctattactg tacgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004315             546 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18942:18389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004315
VERSION     KCXD01004315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 546)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 546)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18942:18389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    184..544
                     /note="immunoglobulin heavy chain variable region"
     V_region        184..544
     V_segment       184..477
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <469..>513
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62797.1"
                     /translation="CARVRGGIAGYFDYW"
     D_segment       486..496
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       499..544
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        545..>546
                     /gene="IGHG"
BASE COUNT          117 a          133 c          163 g          133 t
ORIGIN      
        1 acatggggct ccctctcctg atgaaaacca gcccagctct gactctgcag ctctaggaga
       61 ggagcccagc cctgggattc ccaggtgttt tcatttgtga tcagcactga acacagaaga
      121 ctcatcatgg agtttggcct gagctgggtt ttccttgttg ctattttaaa aggtgtccag
      181 ggtgacgtgc agctggtgga gtctgggggc ggcttggcac agcctggggg gtccctgaga
      241 ctctcctgtg cagcctctgg attcagcttc agttactact ggatgtactg ggttcgccag
      301 gcaccaggaa aggggctgga gtggatctca gttattgata gtggtggtga taacacatac
      361 tatgcagact ccatgaaggg ccgattcacc atctccagag agaacgccaa gaacacactg
      421 tatcttcaaa tgaacagcct gagtgctgag gacacggctg tctatttctg tgcgagagtc
      481 agggggggta tagcagggta ctttgactac tggggccagg gagtcctggt caccgtctcc
      541 tcagcc
//
LOCUS       KCXD01004316             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:10964:19030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004316
VERSION     KCXD01004316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:10964:19030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62798.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       423..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          119 a          143 c          132 g           98 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg attggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgatttat ccatacactg gatacgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac acatacagcc
      361 ttcatggaat tgagcagcct gaaatctgac gacacggccg tatatttctg tgcgagtggg
      421 cctagcggca cctggatcga ctggtccttc gatgtctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01004317             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11895:8475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004317
VERSION     KCXD01004317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11895:8475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62799.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       412..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          143 c          129 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc gcctgcgctg tttctggtga
      181 ctccatcaac agtggctact actggagctg gatccgccaa cccccagaga aggggctgga
      241 gtggattggg tttttcggtg gtagtagtgg tagcacctac tacaacccct ccctcaagag
      301 tcgagtcacc ctttcaaaag acacgtccag gaaccagttc tccctgaaac tgacctctgt
      361 gaccgccgcg gacacggccg tctattactg tgcgagaaaa cttccaggtc tgcaactaac
      421 cggtttcgat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004318             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16542:13604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004318
VERSION     KCXD01004318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16542:13604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..444
     V_segment       84..371
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <366..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62800.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       372..378
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..444
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          100 a          114 c          130 g          102 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacttg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaggtcc agttggcgca gtctggggct gacgtgaaga
      121 agcctggggc ctcagtgaag gtctcctgta aggtttccgg atacaccttc accgaattat
      181 ccctgcactg ggtgcgacag ggccctggaa aaggacttga gtggatggga ggttttgctc
      241 ctatatatgg tgaattaatc catgaaaggt tccagggaag agtcagtttg accgaggaca
      301 cgtctacaga cacagcctat atggagctga gcagcctgag atctgaggac acggccgtgt
      361 attattgtgc ggcagctgac agtggttacc cattttacta cttcgatatt tggggccctg
      421 gcaccccaat caccgtctcc tcagcc
//
LOCUS       KCXD01004319             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17721:5124
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004319
VERSION     KCXD01004319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17721:5124"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62801.1"
                     /translation="CVRDAFGSGFDVW"
     D_segment       438..443
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          109 c          159 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctatggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagtgat atcgtatgat
      301 gaaaataaga agtactacgc agactctgtg aagggccgat tcaccgtctc cagagacaat
      361 tccaagaata tgatatatgt tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttctgtgtga gagatgcatt tgggtcgggg ttcgatgtct ggggcccggg agtcctggtc
      481 gccgtctcct cagcc
//
LOCUS       KCXD01004320             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20819:9708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004320
VERSION     KCXD01004320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20819:9708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62802.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          139 c          128 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtcaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaggagt
      301 cgagtctcca tttcaacaga cacgtccaag aaccactttt ccctgaggct gcgttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004321             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11959:4813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004321
VERSION     KCXD01004321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11959:4813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..457
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62803.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       402..408
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           90 a          144 c          129 g           96 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga acatgaggca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct acaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagca gtaacttctg gagctggatc cgccagcccc cagggaaggg actggagtgg
      241 attggacgta tctatggtag tactgatagc accagctaca acccctccct cacgagtcga
      301 gtcaccattt caacagacac gtccaagaac cagttctccc tgaagctgac ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagatgcgg gaactgggac cccctttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004322             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16816:22463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004322
VERSION     KCXD01004322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16816:22463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..516
     V_segment       135..428
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62804.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       438..444
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..516
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          109 a          117 c          157 g          135 t
ORIGIN      
        1 acatggggag gagccacagc cccgggattc ccagctgtct ccacttggtc atgaacactg
       61 aactcagaag acgcaccatg gagtttgtgc tgagtttgct tttccttgtt gcttttttaa
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggta aagcctgggg
      181 ggtccctgag actctcttgt gtagtctctg gattctcctt cagtaactat gttatgcatt
      241 gggtccgcca ggctccagga aagggtctgg ggtgggtctc acttattagt ggaagtggtg
      301 gtaccacaga ctacgcagac tctgtgaagg gccgattcac cctctccaga gacaacgcca
      361 aggaatcgct ttttctgcaa atgaacagcc taagagccga ggacacggcc gtgtattact
      421 gtgctagagg cggggaaata gtggattcag agattattga ggattactac ggtttggatt
      481 tctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01004323             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6433:4684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004323
VERSION     KCXD01004323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6433:4684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62805.1"
                     /translation="CAGGPSGIWNGWYFDIW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          115 a          143 c          136 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgacttatcc attcactggg tgcgactggc
      241 ccctggaaaa gggcttcagt ggatcggaag tgttgatcct gcatatggtg aaatgataaa
      301 cgcagagaat ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagtta agcagcctga gatctgagga cacggccgtg tattactgtg cgggtggccc
      421 tagcggcatc tggaacggct ggtacttcga tatctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01004324             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15686:2571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004324
VERSION     KCXD01004324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15686:2571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62806.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       414..420
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           83 a          138 c          142 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgaagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccatcagc actcactcct ggagctgggt ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggcg cacggactac aatccctccc tcaagagtcg
      301 agtcaccttt tcaacagaca cgtccaggaa ccagttgtcc ctgaggctga cgtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagttgaa agcgcctggt ccgtggggtg
      421 ggattactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004325             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7110:20629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004325
VERSION     KCXD01004325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7110:20629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..453
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62807.1"
                     /translation="CARWDSADFDYW"
     D_segment       405..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>457
                     /gene="IGHG"
BASE COUNT           86 a          130 c          136 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtggttatg gctggagctg gatccgacag gccccaggga agggactaga
      241 gtggattggg gttttctatg gtcatagtgg tagcacccac tacaacccct ccctcaaaaa
      301 tcgagtcacc ttttcaaaag acgcgtccaa gaatcagttc tccctgaagg tgacctctgt
      361 gaccgccgcg gacacggccg tgtatttttg tgcgagatgg gactcagcgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcggcc
//
LOCUS       KCXD01004326             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22579:18768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004326
VERSION     KCXD01004326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22579:18768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62808.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          101 a          144 c          128 g          106 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgaa actggtgcag tctggggcag aggtgagaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccaccaactg gatcagttgg gtgcgccaga
      241 cgcccggaaa aggcctggaa tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 ccaacccgtc cttccaaggc cacgtcacta tctcagccga caagtccatc agtaccacct
      361 acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtatttctgt gcgaaaacct
      421 actatagtgg tagtttggaa atctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004327             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18433:10698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004327
VERSION     KCXD01004327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18433:10698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62809.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          111 c          155 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt attccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtact tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaataa atactacgca gactctgtga aggcccgatt caccgtctcc agagacaatt
      361 ccaagaacat gttatatctt caaatggaca acctgaaatt ggaagacacg gccgtgtatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004328             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21035:6286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004328
VERSION     KCXD01004328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21035:6286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..422
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62810.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       433..438
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          115 c          149 g          115 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccactgt gaagtgcagc tggtggagtc tggaggaggc ttggttcagc cgggggggtc
      181 cctgagactc tcctgtgcag tctctgggtt caccttcagt ggctctggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggaatg ggtggcggtt atatcgaatg atggaactaa
      301 caaatactac gcagactctc tgaaggaccg atttagtatc tccagagaga attccaagaa
      361 catgctatat cttcaaatga acaacctgaa actggaggac acggccgtct attactgcgc
      421 gacagatgcg tttggtagcg ggattgacta ctggggccgg ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01004329             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13744:17965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004329
VERSION     KCXD01004329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13744:17965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62811.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..432
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          114 a          143 c          140 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg caacagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atacaccttc accgaaatct ccatgcactg ggtgcgacag
      241 gcccccggaa aaggacttga gtggatggga agtgttgatc ctgtgtatag tgaagaaata
      301 ctcgcagata atttccacga cagagtcacc atgaccgagg acacgtctac aggcacagcc
      361 tacatggagc tgagcagcct gaagtctgag gacacggccg tatatttctg tgcggcgggc
      421 cttggggggt atctagtgct tactgagtac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01004330             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11175:7887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004330
VERSION     KCXD01004330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11175:7887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62812.1"
                     /translation="CARTTSRGLVFDFW"
     D_segment       399..403
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..460
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           91 a          139 c          128 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcagttactg gtggaactgg atccgccagc ccccagggaa gggactggag
      241 tggcttgggg agatcaatgg taatagcgga accaccaact acaatccctc cctcaagagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aatcagttct ccctgaacct aaattctgtg
      361 accgccgcgg acacggccgt ctatttctgt gcgaggacca cctcccgggg acttgttttt
      421 gatttctggg gccaagggct cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01004331             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:19819:17853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004331
VERSION     KCXD01004331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:19819:17853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..449
     V_segment       98..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62813.1"
                     /translation="CASNSITSGPDYW"
     D_segment       393..399
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..449
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           86 a          139 c          129 g           97 t
ORIGIN      
        1 acatgggggg agaggcacgg acatcctgtg caagaacatg aggcacctgt ggttcttcct
       61 cctcctggtg gcagctccca gatgggtcct gtcccgcctg cagctgcagg cggcgggccc
      121 aggactggtg aagccttcgg agaccctgtc tctcacctgc gctgtctctg gtggctctat
      181 cagcggtaac tactggagct ggatccgccg ggccccaggg aagggactgg agtggattgg
      241 atatatctac ggtagtgatt ttaccaccaa ctacaacccc tccctcaaga gtcgagtcac
      301 cctgtcagca gatacgtcca agaaccagct ctccctgaac ctggcctctg tgaccgccgc
      361 ggacacggcc gtctatttct gtgccagtaa tagtataaca tctggtccag attactgggg
      421 ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004332             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16269:13390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004332
VERSION     KCXD01004332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16269:13390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62814.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       439..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..503
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          104 a          141 c          148 g          112 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 caccactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttcttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcgaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca acacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtac
      301 tgctggtagc acatactacg cagactccgt gaagggccgc ttcaccgtct ccagagacaa
      361 ctcaaagaac acgctctccc tccaagtgaa cagcctgaga cctgaggaca cggccgtgta
      421 ttactgtgcg aaaggaggta gcagctcttt ctactggtac ttcgatatcc ggggccctgg
      481 caccccagtc accatctcct cagcc
//
LOCUS       KCXD01004333             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7785:18017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004333
VERSION     KCXD01004333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7785:18017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62815.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          141 c          148 g           98 t
ORIGIN      
        1 acatggggtt cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgagatccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgccag gtgtccggat acacgttcag tgaaatctcc atgcactggg tgcgacagac
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agtagcctga gatctgacga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004334             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:26250:15041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004334
VERSION     KCXD01004334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:26250:15041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62816.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           82 a          137 c          143 g           98 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtacaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacctactac aacccctccc tcaagagtcg
      301 agtcaccact tcaccagaca cgtccaaaga ccagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004335             433 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8198:20320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004335
VERSION     KCXD01004335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 433)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 433)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8198:20320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    53..431
                     /note="immunoglobulin heavy chain variable region"
     V_region        53..431
     V_segment       53..344
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <338..>400
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62817.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       359..371
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       382..431
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        432..>433
                     /gene="IGHG"
BASE COUNT           92 a          110 c          141 g           90 t
ORIGIN      
        1 acatgggggg aggatcctcc tcttggtggc agcagctaca ggcgcccact ctgaggtcca
       61 gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg tctcctgcca
      121 ggtttccgga tacaccttca gtgaaatgtc catgcactgg gtgcgacagg cccctggaaa
      181 agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac acgcagagaa
      241 cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggagct
      301 gagtagcctg agatctgagg acacggccgt gtattactgt gcgacaggga ggttcgggag
      361 cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg tcgtcgtcac
      421 cgtctcctca gcc
//
LOCUS       KCXD01004336             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18995:19773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004336
VERSION     KCXD01004336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18995:19773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..511
     V_segment       146..431
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62818.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          124 c          145 g          129 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 ttctatatta aaaggtgtcc agtgtgtgga gcatctggtg gagtctgggg gaggcttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct gaattcacct tcagtggcta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtcta gaatggctat caggtattaa
      301 cattggcggt gacccatact acccagactc tgtgaagggt cgattcacca tctccagaga
      361 caacgccaag aactccttgt atcttcaaat gaacaacctg agacctgagg acactgctgt
      421 gtattattgt gtgaggggga tggataacta ccacttcagt aatacggact ttgactactg
      481 gggccaggcg tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004337             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:5087:6410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004337
VERSION     KCXD01004337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:5087:6410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62819.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          109 a          144 c          134 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcag gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatac tctgtatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac ttggaactga
      361 gcggcctgac ttctgaggac acggccgtgt attactgtgc gactggccct accggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004338             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21936:16751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004338
VERSION     KCXD01004338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21936:16751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62820.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       443..447
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          138 c          143 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc agcgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaga acctccaggg cagagtcgcc atgaccgagg acacgtctac agacacagcc
      361 tacatggaat tgagcagcct gagatctgag gacacggccg tttattactg tgcgagaggt
      421 ttatcaccag acgtcttcgg tttcctcggg cttggctact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004339             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18931:12526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004339
VERSION     KCXD01004339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18931:12526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62821.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          153 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg gttcaccttc agtcactttg
      241 gcttacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatggaaa taagatatac tactcagact ctgtgaagga ccgattcacc atctccagac
      361 acaattcgaa gaatgtggta tatcttcaaa tggacaacct gaaattggag gacacggccg
      421 tctatttctg tgtgagagat gcctacggta ccgggttaga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004340             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13133:13199
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004340
VERSION     KCXD01004340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13133:13199"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62822.1"
                     /translation="CARAVGGAAGYFDFW"
     D_segment       432..439
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          124 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcagttact actacatgaa
      241 ctgggtccgc cagactccag ggaagggcct ggaatggatc tcaggtatta acagtggtgg
      301 cattaacaca tactatgcag actccgtgaa gggcagattc accatctcca gagaggacgc
      361 caagaaaaca ctgtttcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gcagtgggtg gtgccgcagg atacttcgat ttctggggcc tgggcgcccc
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004341             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11971:10650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004341
VERSION     KCXD01004341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11971:10650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62823.1"
                     /translation="CARYSYGGSYFFGFFDFW"
     D_segment       395..403
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          134 c          133 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cttgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactcct ggagctggat ccgccaggcc ccagggaagg ggctggaatg
      241 gattggatat atctatggcg gtagtgggaa caccacctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaaaagaca tgtccaagaa ccagttttcc ctgaagttga tctctgtgac
      361 cgccgcggac accgccgtgt attattgtgc gagatacagt tacggtggca gctatttctt
      421 tgggttcttt gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004342             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18401:11155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004342
VERSION     KCXD01004342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18401:11155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62824.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          120 c          153 g          118 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 gccctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttttgtcgt
      301 ctgatggagg ttacaaatac cacgcagact ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004343             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:10051:4444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004343
VERSION     KCXD01004343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:10051:4444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..283
     V_segment       8..206
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <199..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62825.1"
                     /translation="CSREWIQWAHLVSGLDSW"
     D_segment       210..223
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       237..283
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           74 a           68 c           84 g           59 t
ORIGIN      
        1 acatgggatg ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca
       61 gccatatcat ttgatggaag taagaaaaac tacgcagact ctgtgaagga ccgattcacc
      121 atctccagag acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag
      181 gacacggccg tgtactactg ttcgagggag tggatacagt gggcacactt agtgagcggt
      241 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004344             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8817:13889
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004344
VERSION     KCXD01004344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8817:13889"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62826.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       405..411
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          134 c          134 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggg ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaga gagtactatt ggagctggat ccgccaggcc ctagggaagg gactggagtg
      241 gattggctac atctatggta acattgggag caccagctat aacccgtccc tccagagtcg
      301 agtcaccgtt tcaatagaca cgtccaagaa tcacttctcc ctgaagttga cgtctgtgac
      361 cgccgcggac acggccgtat atcactgtgc gagacatctc tattcctgga aagggaagtg
      421 gatcgatgtc tggggcccgg gagtcctgat caccgtctcc tcagcc
//
LOCUS       KCXD01004345             306 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8004:11834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004345
VERSION     KCXD01004345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 306)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 306)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8004:11834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..304
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..304
     V_segment       8..243
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <235..>273
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62827.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       252..256
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       263..304
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        305..>306
                     /gene="IGHG"
BASE COUNT           72 a           79 c           82 g           73 t
ORIGIN      
        1 acatgggtct cctgtgcagc ctctggattc accttcagtt cctttggcat gcactgggtc
       61 cgccaggcac cggggaaggg gctggagtgg gtggcagttt tatcgtctga tggaactaac
      121 aaatactacg cagactcttt gaaagaccga ttcaccatat ccagagacaa ctccaagaac
      181 atactatatc ttcaactgaa caacctgaaa ttggaggaca cggccgtgta ttactgtgcg
      241 agagatgtgt atggctcggg gcttgactac tggggccagg gagtcctgct caccgtctcc
      301 tcagcc
//
LOCUS       KCXD01004346             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:9048:17273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004346
VERSION     KCXD01004346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:9048:17273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62828.1"
                     /translation="CARDAGVGAIALYYYDYW"
     D_segment       403..408
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          132 c          140 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtgg
      181 ctccttcagt ggttactact ggatctggat ccgccagccc ccagggaagg gactggaatg
      241 gattgggggt gtcggtggtg gtagtgggat caccgaatac aatcccaccc tcaaaagtcg
      301 agtcactatt tcaagagaca cgtccaagaa ccaattctcc ctgaaactga gctctatgac
      361 cgccgcggac acggccgtgt attactgtgc gagagatgcg ggagtggggg ccatagccct
      421 ttactactat gactactggg gccagggagt cttggtcagc gtctcctcag cc
//
LOCUS       KCXD01004347             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:4748:6803
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004347
VERSION     KCXD01004347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:4748:6803"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62829.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       438..450
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          114 c          147 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctgggtc cctgagactc tcctgtgcag cctctggatt caccttcaga aactatggca
      241 tgcactgggt ccgccaggcc ccagggaagg ggctggattg ggtggcagtt atgtcgtttg
      301 atgaaaatgt gaaattctac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccttgt
      421 attactgtgc gagaggggaa tacagtaact ctattgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004348             370 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9758:4509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004348
VERSION     KCXD01004348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 370)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 370)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9758:4509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    11..368
                     /note="immunoglobulin heavy chain variable region"
     V_region        11..368
     V_segment       11..303
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <296..>337
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62830.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       309..314
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       320..368
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        369..>370
                     /gene="IGHG"
BASE COUNT           83 a           86 c          113 g           88 t
ORIGIN      
        1 acatgggtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc ctggggggtc
       61 cctgagactc tcctgtgtag cctctggatt caccttcagt agctatggca tgcactgggt
      121 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtacg atgaagacaa
      181 gagatactac gcagactctc tgaaggaccg attcaccatc tccagagaca attccaagaa
      241 catgctttat cttcaaatga acaacctgaa attggaggac acggccgttt attactgtgc
      301 gaggaggccc tggagtgcag atgcttttga tttctggggc caaggactca gggtcaccgt
      361 ctcttcagcc
//
LOCUS       KCXD01004349             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16418:15573
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004349
VERSION     KCXD01004349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16418:15573"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..521
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62831.1"
                     /translation="CARDLPYSWNDGGHNGAFDFW"
     D_segment       446..460
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..521
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          111 a          121 c          166 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaggttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag ggattagtag
      301 tggtgggggt ggcacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagttgagg acacggctgt
      421 ctattactgt gcgagagatc taccctatag ttggaacgac ggtggtcata atggtgcttt
      481 tgatttctgg ggccaagggc tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01004350             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19318:8229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004350
VERSION     KCXD01004350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19318:8229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62832.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       412..421
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          144 c          136 g          100 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggc
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccctcagaga ccctgtccct cacctgcgct gtctctggtg
      181 cctccatcgg tagttactgg tggacctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatgga aatagtggta gtacctacta tagcccctcc ctcaagagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga accacctctc cctgaagctg aactctgtga
      361 ccaccgcgga cacggccgtg tatttctgtg cgaacgtctt aggcccctgg ggcagctggt
      421 cacactactt tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004351             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:28636:9868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004351
VERSION     KCXD01004351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:28636:9868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62833.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          108 c          153 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttcctta ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcacctggt ggagtctggg ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcatg ttcagtaact atggcatcca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg tcagttatat cgtatgatgt
      301 aactgtgaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaatacg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ttgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      481 cgtctcgtca gcc
//
LOCUS       KCXD01004352             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19466:10469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004352
VERSION     KCXD01004352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19466:10469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62834.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       425..431
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          138 c          149 g          101 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccaac tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggaga caccttcacc gaattatcca tgcactgggt tcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgatcctg caagtgatga agtaatacac
      301 gcagatggtt tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcggcctgag atctgaggac acggccgtgt attactgtgc gagagggagg
      421 ttcggtagta gcgtctggtc caatctcgtc tatggtttcg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004353             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15669:7265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004353
VERSION     KCXD01004353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15669:7265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62835.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       435..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          137 c          149 g          105 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccaa ctggtggagt ccggggctga ggtgaagaag cctggggcct cagcgaagct
      181 ctcctgcaag gccgctggat acattttcag tacctctgcc atcagttggc tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggggg gatcatgcct cttgttggta gaacaaacta
      301 cgcacagagg ttccagggca gagtcacgat taccgcggac acgtccacaa ggacagccaa
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cgagcggtgg
      421 tttccaggat gagaacggtt actattttcc agactatttt gacttttggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004354             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8890:6348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004354
VERSION     KCXD01004354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8890:6348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62836.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          120 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaactccaa gaatatgcta tatcttcaac tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004355             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10618:20972
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004355
VERSION     KCXD01004355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10618:20972"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62837.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          115 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtgg
       61 tcagcacaga acacagagga ctcaccatga aatttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cggcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatgaaac taagaaatac tacggagact ctgtgaaggg ccgattcagc atctccagag
      361 acaattcgaa gaacatgcta tatcttcaaa tgaacaccct gaaattggag gacacggccg
      421 tgtattactg tgcgacagat gcgtttggta gcgggattga ccactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004356             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21150:13088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004356
VERSION     KCXD01004356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21150:13088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..456
     V_segment       93..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62838.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       390..397
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           94 a          131 c          128 g          105 t
ORIGIN      
        1 acatggggag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg ttcttccttc
       61 tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag tcgggcccag
      121 gactggtgaa gtcttcggag accctgtccc tcacctgcgg tgtctctggt gactccatca
      181 gcaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag tggattgggt
      241 atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt cgagtcacca
      301 tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg accgccgcgg
      361 acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac cactttgact
      421 gctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004357             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9828:18595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004357
VERSION     KCXD01004357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9828:18595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..515
     V_segment       137..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62839.1"
                     /translation="CAKDLPYTWNDGGHNGVFDFW"
     D_segment       443..454
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          112 a          123 c          160 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgcc cagtgtgagg agcagctggt ggagtcgggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagg ttcagttact actacatggc
      241 ctgggtccgc caggctccag ggaaggggct agagtggatc tcaggtatta gtagtggtgg
      301 gggtagtaca tattatacag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caacaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgcgcgaag gatcttccct atacctggaa cgacggtggt cataatggtg tttttgattt
      481 ctggggccaa gggctcaggg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004358             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20570:9916
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004358
VERSION     KCXD01004358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20570:9916"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62840.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       421..432
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          110 a          139 c          139 g           95 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccttctggt gcagtctggg gctgaggtga tgcagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggaagaacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtgggtg ggaagtgttg atcctgaata tggtgaaatg
      301 atgttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc ctacatggag
      361 ctgagcagcc tgagatctga ggacacggcc gtctattact gtgcgattgg ccctagtggc
      421 agctggaacg actggtcctt cgacatttgg ggacctggca ccccaatcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01004359             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18542:17411
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004359
VERSION     KCXD01004359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18542:17411"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62841.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           85 a          139 c          136 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttttcggtg gtagtggtgg gagcacctac tacaaatcct ccctccagag
      301 tcgcgtcacc atttcaaccg acacgtccaa gaaccagttc tccctaatac tgacctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat
      421 tgactactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004360             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16724:10709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004360
VERSION     KCXD01004360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16724:10709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62842.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       427..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          133 c          149 g          104 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgga gtccggggct gaggtgaaga agcctggggc cacagcgaag ctctcctgca
      181 aggccgctgg atacattttc agtacctctg ccatcagttg gctgcgacag gcccctggac
      241 aagggcttga gtggatgggg gggatcatgc ctcttgttgg tagaacaaac tacgcacaga
      301 ggttccaggg cagagtcacg attaccgcgg acacgtccac aaggacagcc aacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattattg tgcgagcggt ggtttccagg
      421 atgagaacgg ttactatttt ccagactatt ttgacttttg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004361             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18077:16182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004361
VERSION     KCXD01004361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18077:16182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62843.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          119 a          143 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga accctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgtattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacctca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004362             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19900:9973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004362
VERSION     KCXD01004362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19900:9973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..490
     V_segment       143..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62844.1"
                     /translation="CTGGAYANLDYW"
     D_segment       443..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>496
                     /gene="IGHG"
BASE COUNT          108 a          131 c          152 g          105 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggtgca gatggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtcgctactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctagaa tgggtctcag ctattaatac
      301 tgatggggag aacacatact acgcagactc cgtgaagggc cgattctcca tctccagaga
      361 caactcaaag accacactct ccctgcaaat gaacagcctg agaccggagg acacggccgt
      421 atattactgt acgggcgggg cgtacgctaa cctcgactac tggggccagg gagtcctggt
      481 caccgtctcc acagcc
//
LOCUS       KCXD01004363             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23305:17975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004363
VERSION     KCXD01004363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23305:17975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62845.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          119 a          144 c          136 g           96 t
ORIGIN      
        1 acatggggag agcatcacac aacagccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tgcaggcgcc
      121 cgctctgagg tccaactgat acagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcgaggtttc cggatacacc ttcaccgaac tgtccatcca ctgggtgcga
      241 caggcccctg gaaaaggcct tgagtggatg ggaagtgttg atcctgaata tggtgaaatg
      301 ataaacgcag aaagattcca gggcagagtc accttgaccg aggacacgtc tacaggaacg
      361 gcctacatgg agctgatcag tctgagatct gaagacacgg ccgtgtatta ctgtgcgaca
      421 tcacccagcg gcacctggct atattggtac ttcgatttct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01004364             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13804:15456
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004364
VERSION     KCXD01004364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13804:15456"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62846.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       436..442
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          114 c          147 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccggtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcaacct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctttggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ttcgtctgat
      301 ggaagtaaca aatactacac agactctgtg aagagccgat tcaccatctc cagagacaat
      361 tcccagaaca tactttatct tcaaatgaac aacttgaaat tggaggacac ggccgtctat
      421 tactgtgcga gagatgatat tgggaccggt tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004365             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:6317:11737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004365
VERSION     KCXD01004365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:6317:11737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62847.1"
                     /translation="CVRDSSGSGFDRW"
     D_segment       442..447
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          112 c          151 g          122 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tacttttggc
      241 atacactggg tccgcctggc tccagggaag gggctggagt gggtggcagt tatatcgtac
      301 gatgaaaata agaaatacta tggagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaaa acatggtata tcttcacatg aacaacctga aattggagga cacggccgtg
      421 tattactgtg tgagagattc aagcggttcg ggatttgacc gttggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004366             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23743:11979
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004366
VERSION     KCXD01004366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23743:11979"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..430
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62848.1"
                     /translation="CTRDKGVYLRYFEFW"
     D_segment       441..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          124 c          151 g          116 t
ORIGIN      
        1 acatggggag agaggagcct tagccctgga tttcaaggca cttccacctg gggatcagca
       61 ctgaacacag aggacccacc atggagttgg ggctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagtgtgag gtgcagcttg tggagtctgg gggaggcttg gtccagcctg
      181 gagggtccct gagactctcc tgtgcagcct ctggattcat cttcagaaat tacggcatga
      241 gctgggtccg ccaggctccg ggaaaggggc tggagtgggt ctcatatatt agtcacacag
      301 gtgaaaccat atactatgct gactccgtga agggccgatt caccatctcc agagacaacg
      361 ccaagaattc gctgtctctg caaatgagca gcctgagagc cgaggacacg gccgtgtatt
      421 attgtactag agataaggga gtatatctcc gttacttcga gttctggggc cagggcgccc
      481 tggccaccgt ctcctcagcc
//
LOCUS       KCXD01004367             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12832:7695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004367
VERSION     KCXD01004367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12832:7695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62849.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           79 a          142 c          138 g          101 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtt atggtgggag cacctactac aacccctccc tccagagtcg
      301 agtcaccatt tcagccgaca cgtccaagca ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct actactgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004368             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19572:15460
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004368
VERSION     KCXD01004368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19572:15460"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62850.1"
                     /translation="CARERCTSSVCAGFLDYW"
     D_segment       408..412
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          140 c          137 g           99 t
ORIGIN      
        1 acatgggcaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgcg
      181 gggcttctgg attcaccttc gacacccatg gtatcaactg ggttcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatac cccttattgg tatcacaaac tacgcaaaga
      301 actctcaggg cagagtcaca ataagcgcga acacgtccac aaacacagcc tacatggagc
      361 tgaacagcct gagatctgag gacacggcca tctactactg tgcgagagaa cgctgcactt
      421 ctagtgtttg cgccgggttc cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004369             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12306:24500
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004369
VERSION     KCXD01004369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12306:24500"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62851.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       444..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          111 c          155 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt catgttcagt aactttggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtcagtt atatcgtatg
      301 atgtaactgt gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cacgctatat cttcaaatgc acaacctgaa attggaggac acggccgtgt
      421 attattgtgt gagagatgtc aggggaacgg ggtttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc gtcagcc
//
LOCUS       KCXD01004370             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:8381:2678
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004370
VERSION     KCXD01004370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:8381:2678"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62852.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       434..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          125 c          157 g          115 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagg tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagc acctatgcta
      241 tgcactgggt ccgccaggct ccaggaaagg ggctggagtg ggtctcagcc attagtgttg
      301 gtggtagtac atactacgca gactccgtga ggggccgatt caccatctcc agagacaact
      361 cagagaacac gctctccctg caaatgaaca gcctgagagc tgaggacacg gccgtatatt
      421 actgtgcgaa aggggataca gctacagttt attacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01004371             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24011:10339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004371
VERSION     KCXD01004371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24011:10339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62853.1"
                     /translation="CARDEDPSIFEYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           94 a          134 c          131 g          104 t
ORIGIN      
        1 acatggggaa ggttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggcgccatc agcagtggtt tctactggac ctggatccgc caacccccag ggaaggggct
      241 ggagtggatt gggtgtatcg gtggtaatag tggtaccacc tactacaagt cctccctcaa
      301 gagtcgagcc accatttcaa aagacacgtc caacaatcaa ctctccctga agttgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt
      421 tgaatactgg ggccagggag tcctggtcac cgtctcttca gcc
//
LOCUS       KCXD01004372             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:18697:18061
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004372
VERSION     KCXD01004372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:18697:18061"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62854.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          144 c          137 g           95 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ttctgaggtc cagctggtgc aatctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctttatatg gtgaaatgat
      301 acacacagaa cagttccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagtgg
      421 ccctagcggc agctggaacg actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004373             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24326:14734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004373
VERSION     KCXD01004373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24326:14734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62855.1"
                     /translation="CTRIGVGSLATAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          108 a          130 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tggcttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctcagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtcgcatcca ttagaaacac
      301 tgggaaaccc gtatactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaattggcg tcggatcttt agcaacggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004374             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21779:18317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004374
VERSION     KCXD01004374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21779:18317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62856.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       438..444
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          115 a          118 c          146 g          119 t
ORIGIN      
        1 atggggagct ctgggagagg agcccagccc tggaggtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttggactga gttgggtttt ccttgctgct
      121 attttaagag gtgtccagtg tgaggtagag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcatcttcaa tacctatgcc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatttcgcat
      301 gatggaaaca agaaatacta cacagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acattcaata tcttcacatg aacaacctga aattggagga tacggccata
      421 tactactgtg cggcctccta cttggggtac ggatttgagt actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004375             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18798:16153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004375
VERSION     KCXD01004375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18798:16153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62857.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          140 c          150 g           97 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gaaatgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagaact tccaggacag ggtcaccatg accgaggaca cgtcgacaga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gacagggagg
      421 ttcgggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004376             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19901:12544
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004376
VERSION     KCXD01004376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19901:12544"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62858.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       441..462
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          117 a          121 c          160 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag gcctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttggtc tgacctgggt tttccttgtt
      121 ggtattttga aaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agccttggct
      181 cagcctgggg ggtccctgag actctcctgt gcagcgtctg ggttcacctt cagtagctat
      241 gccatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agccatatca
      301 tttgatggaa gtaagaaaaa ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaactcca acaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatactact gttcgaggga gtggatacag tgggcacagt tagtgagcgg tttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004377             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24395:16680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004377
VERSION     KCXD01004377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24395:16680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62859.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       411..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           92 a          139 c          142 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcgggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagtaa ttggtggagc tggatccgcc agtccccagg gaagggactg
      241 gaatggattg ggggtatcta tggtagtggt gggaataccg aatacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa ggacacgtcc aagaaccagt tctccctgaa gctgaactct
      361 gtgaccgccg cggacaccgc cgtgtattac tgtacgagag aatggggcgc tatagcggca
      421 gttgggcctg tccttgcctc ctggggccag ggtgtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004378             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13920:8728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004378
VERSION     KCXD01004378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13920:8728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62860.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       406..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          104 a          144 c          133 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagccc ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attgtccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagcggg tgggaagtgt tgatcctgta tatggtgaaa tgatgttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag
      361 cctgacatct gacgacacgg ccgtctatta ctgtgcgatt ggccctagcg gcagttggaa
      421 ccactggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01004379             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15120:9228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004379
VERSION     KCXD01004379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15120:9228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62861.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          142 c          141 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggaattg agcagcctga catctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaatctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004380             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12946:5850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004380
VERSION     KCXD01004380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12946:5850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62862.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       434..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          115 a          110 c          154 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaactaagaa gtactacgga gactctgtga aagaccgatt caccatttcc agagacaatt
      361 ccaagaacag gctatatctt caaatgaaca acctgaaatt ggaggacacg gcagtatatt
      421 actgtgcgag agatgatagt ggggtgatca tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01004381             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19860:14029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004381
VERSION     KCXD01004381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19860:14029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62863.1"
                     /translation="CAAGHSGTWNHWYFDVW"
     D_segment       415..424
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          120 a          140 c          129 g           89 t
ORIGIN      
        1 acatggggac cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcgacag gcgcccactc
      121 tgaggtccaa ctaatgcagt ctggggctga ggtgaagaag cctgggacct cagttaaggt
      181 ctcctgcaag gtttccggat acaccttcag cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtggcaag tgttgaccct gcatatggtg aaatgaaaca
      301 cgtagacagg gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaga tctgaggaca cggccgtgta ttactgtgca gccggacata gtggcacctg
      421 gaaccactgg tacttcgatg tctggggccc tggcacccca atcaccattt cctcagcc
//
LOCUS       KCXD01004382             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:3719:15935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004382
VERSION     KCXD01004382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:3719:15935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62864.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          115 c          145 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcttgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaactaagaa atactacgta aactctataa aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctc caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatctt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004383             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:21406:14054
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004383
VERSION     KCXD01004383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:21406:14054"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..482
     V_segment       122..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62865.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       410..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          113 a          134 c          131 g          106 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacttgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggcgcagt ctggggctga cgtgaagaag cctgggtcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccttcac cgaattatcc ctgcactggg tgcgacaggg
      241 ccctggaaaa ggacttgagt ggatgggagg ttttgctcct atatatggtg aattaatcca
      301 tgaaaggttc cagggaagag tcagtttgac cgaggacacg tccacagaca cagcctatat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat tattgtgcgg cagctgatag
      421 tggttaccca ttttactact tcgatatctg gggccctggc accccaatca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01004384             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11831:16035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004384
VERSION     KCXD01004384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11831:16035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..336
     V_segment       1..277
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62866.1"
                     /translation="CASSDYGWFDVW"
     D_segment       282..290
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..336
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           73 a           91 c           95 g           79 t
ORIGIN      
        1 tgcaggaatc ggacccagga gtagtgaagc cttcggagac cctgtccctc acctgcgttg
       61 tctctggtgg cgatagttat aggtggagct ggatccgcca gcccccaggg aagggactgg
      121 aatggattgg gtatatttat ggtagtatta cggacaccaa ctacaacccc tccctcaaaa
      181 gtcgagtcac catttcaaaa gacacgtcca agaagcagtt ctccttgaaa ctgagctctg
      241 tgaccgtcgc ggacacggcc gtgtatttct gtgcgagttc agactacggt tggttcgatg
      301 tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004385             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12848:22617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004385
VERSION     KCXD01004385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12848:22617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62867.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          101 a          123 c          160 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttat gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcggctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggggtggatc tcaggtatta gcagtggtgg
      301 ggatgacaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaccaca ctgtatcttc aaatggacag cctgacagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcgtt gtcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004386             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15023:16750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004386
VERSION     KCXD01004386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15023:16750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62868.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          118 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattattg tgcgagagga gactacggta acagccttga cttctggggc cagggaatcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01004387             382 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:4085:16656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004387
VERSION     KCXD01004387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 382)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 382)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:4085:16656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    17..380
                     /note="immunoglobulin heavy chain variable region"
     V_region        17..380
     V_segment       17..310
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <302..>349
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62869.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       320..326
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       336..380
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        381..>382
                     /gene="IGHG"
BASE COUNT           77 a           98 c          121 g           86 t
ORIGIN      
        1 acatggggtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
       61 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact acttcatgag
      121 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta ccagtggtgg
      181 ggataacaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      241 caagaccaca ctgtatcttc acatggacag cctgagagct gaggacacgg ctgtctatta
      301 ctgtgcaaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      361 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004388             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14577:18971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004388
VERSION     KCXD01004388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14577:18971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62870.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          105 a          122 c          157 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagtctc tggattcagt ttcagtcact acttcatgag
      241 ctgggtccgc caggctccag ggaagggact ggagtggatc tcagggatta acagtggtgg
      301 agataccaca cactatgcag actccgtgaa gggcagattc accatgtcca gagagaacgc
      361 caagaacaca ctgtcccttc aaatggacgg cctgagagct gaagactcgg ctgtctatta
      421 ttgtgcgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004389             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10676:13720
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004389
VERSION     KCXD01004389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10676:13720"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62871.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       444..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          106 a          121 c          157 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggtga
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttatttct
      241 acatgagctg ggtccgtcag gctccaggaa aggggctgga gtggatctca agtattgaca
      301 atggtgggac taccacaaat tttgcagact ccgtgagggg caggttcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattattg tgcgagagcg cgcggggtga tcattacata ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004390             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16832:8059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004390
VERSION     KCXD01004390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16832:8059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..499
     V_segment       119..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62872.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       419..432
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>505
                     /gene="IGHG"
BASE COUNT          113 a          138 c          147 g          107 t
ORIGIN      
        1 acatggggac aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccacctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaagctctc
      181 ctgcaaggct tctggataca ccttcagcat ctcttccatc agttgggtgc gacaggcccc
      241 tggacaaggg cttgggtgga taggagggat catccctctt gttggtatga caaactacga
      301 acaggagttc cagggcagag tcacgattac cgcggacacg tccacgaata cagtcttcat
      361 ggaactgagc agcctgagat cggaggacac ggccgtctac tattgtgcga caggggtata
      421 ttaccaggat gaaaacggtt atttttatgt cggcggggac tttgactact ggggccaggg
      481 agtcctggtc accgtctccc cagcc
//
LOCUS       KCXD01004391             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19809:20176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004391
VERSION     KCXD01004391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19809:20176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..497
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62873.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       417..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          111 a          137 c          146 g          109 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccacctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaagacttc tggatacacc ttcagcatct ctgccatcag ttgggtgcga caggcccctg
      241 gacaagggct tgggtggatg ggagggatca tccctcttgt tggtgtgaca aactacgaac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacgaataca gtcttcatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtctacta ttgtgcgaca ggggtatatt
      421 accaggatga atacggttat ttttatgtcg gcggtgactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01004392             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22480:12783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004392
VERSION     KCXD01004392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22480:12783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62874.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       400..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           94 a          133 c          141 g          105 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctctggaga ccctgtccct cacctgcgtt gtctctggtg
      181 gctccatgag cagtaactac tgcagctgga tccgccagtc cccagggaag ggactggagt
      241 ggattggacg gatctctggt agtggtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ctcaagagac acgtccaaga aggagatctc cctgaagctg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagagaaga ctatggtggt aattattact
      421 ttaatcggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004393             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:9564:9259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004393
VERSION     KCXD01004393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:9564:9259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..324
     V_segment       8..248
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62875.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       250..256
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..324
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        325..>326
                     /gene="IGHG"
BASE COUNT           75 a           80 c           98 g           73 t
ORIGIN      
        1 acatggggaa ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact
       61 gggtgcgaca ggcccctgga aaagggcttg agtggatggg aggtgttgat actgtatctg
      121 atggagtgat atacgcagaa aacttccagg gcagagtcac catgaccgag gacacgtcta
      181 cagacacagc ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattatt
      241 gtgcgagagg tgtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg
      301 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004394             364 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19628:4977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004394
VERSION     KCXD01004394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 364)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 364)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19628:4977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..361
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..361
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>331
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62876.1"
                     /translation="CATADYGNSLDFW"
     D_segment       305..316
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..361
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        362..>364
                     /gene="IGHG"
BASE COUNT           84 a           90 c          105 g           85 t
ORIGIN      
        1 acatggggag gtgcaactgg tggagtcggg gggaggcttg gttcagcctg gggggtccct
       61 gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcttgc actgggtccg
      121 ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg gaaatatgaa
      181 atactacgca gactctatga aggaccgatt caccatctcc agagacaatt ccaagaacat
      241 actatatctt caagtgaaca acctgaaatt ggaagacact gccgtttatt actgtgcgac
      301 agccgactac ggtaacagcc ttgacttctg gggccaggga gtcctggtca ccgtctcctc
      361 aacc
//
LOCUS       KCXD01004395             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21211:14141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004395
VERSION     KCXD01004395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21211:14141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62877.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          114 a          140 c          135 g           98 t
ORIGIN      
        1 acatggggac acaacagcca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctgcaggcg cccgctctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcgaggtt tccggatata ccttcaccga actgtccatt cattgggtgc gacaggcccc
      241 tggaaaaggc cttgagtgga tgggaagtgt tgatcctgaa tatggtgaaa tgataaacgc
      301 agaaaaattc cagggcagag tcaccttgac cgaggacacg tctacaggaa cggcctacat
      361 ggacctgatc agtctgagat ctgaagacac ggccgtgtat tactgtgcga catcacccag
      421 cggcacctgg ctatattggt acttcgattt ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01004396             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21001:15491
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004396
VERSION     KCXD01004396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21001:15491"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62878.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcctagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004397             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23832:9606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004397
VERSION     KCXD01004397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23832:9606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62879.1"
                     /translation="CAKGETATPYYGLDSW"
     D_segment       441..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          129 c          153 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagatgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatacactg ggtccgccag gctccaggga agggactgga gtgggtctca gctattagca
      301 ctggtggtag gacattctac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccatgt
      421 attactgtgc gaaaggggaa acagctacac cttactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004398             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13130:2981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004398
VERSION     KCXD01004398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13130:2981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..401
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62880.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       413..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           93 a          139 c          143 g          104 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcggg
      121 agtcgggccc agcagtggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat caccagtagt aattggtgga gctggatccg ccagtcccca gggaagggac
      241 tggaatggat tgggggtatc tatggtagtg gtgggaatac cgaatacaac ccctccctca
      301 agagtcgagt caccatttca aaggacacgt ccaagaacca gttctccctg aagctgaact
      361 ctgtgaccgc cgcggacacc gccgtgtatt actgtacgag agaatggggc gctatagcgg
      421 cagttgggcc tgtccttgcc tcctggggcc agggtgtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004399             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24239:16121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004399
VERSION     KCXD01004399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24239:16121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62881.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       263..268
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           70 a           85 c           97 g           68 t
ORIGIN      
        1 acatgggggg gtccctaaga ctctcctgtg cagcatccgg attcaccttc agtgaccact
       61 gcatgcactg ggtccgccag gcttcaggga aggggctgga gtgggtctca ggtattactt
      121 atgctggtgt taccacatgg tacgcagact ccgtgagggg cagattcacc atatccagag
      181 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagacctgag gacacggctg
      241 tctattactg tgtgggagga aggcggcacg tggaccttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004400             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:3891:8931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004400
VERSION     KCXD01004400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:3891:8931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..466
     V_segment       106..402
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62882.1"
                     /translation="CARDSLGRSPYDYW"
     D_segment       411..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          139 c          132 g          101 t
ORIGIN      
        1 acatggggga aatgttctct gagagtcatg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggccc tgtcccaggt gcagctgcag
      121 gggtcgggcc caggagtggt gaagccttcg gagaccctgt ccctcacctg cggtgtctct
      181 ggtggctcca tcagagatag ttacagatgg agttggatcc gccagccccc agggaaggga
      241 ttggagtgga ttggttacat ctatgggagt agttcgagca ccaactacaa cccctccctc
      301 aaaaggcgag tcaccatttc aaaagacacg tccacgaacc agttctcctt gaacctgatc
      361 tctgtgaccg ccgcggacac ggccatctat tactgtgcgc gagattccct cggtaggagc
      421 ccctacgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004401             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18826:5471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004401
VERSION     KCXD01004401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18826:5471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62883.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          118 c          149 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccactgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaagtt ggacgacacg gccgtctatt
      421 actgtgcgag agacgcattt ggcagcggct gtgactactg gggccggggc gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004402             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18260:7252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004402
VERSION     KCXD01004402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18260:7252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62884.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       416..423
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           99 a          138 c          144 g           98 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggctggga gggatcgtcc ctcttgttgg aacaacaaac tccgcacaga
      301 agttccagga cagagtcacg attaccgcgg acacgtccac aagcacagtc tacatggagc
      361 tgagcagcct gagatctgac gacacggccg tgtattactg tgcgagaggc ctgggtagca
      421 gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004403             308 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21111:16740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004403
VERSION     KCXD01004403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 308)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 308)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21111:16740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..306
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..306
     V_segment       8..231
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <225..>275
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62885.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       239..254
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       257..306
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        307..>308
                     /gene="IGHG"
BASE COUNT           69 a           87 c           89 g           63 t
ORIGIN      
        1 acatgggggt ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg
       61 tgcgacaggc cccaggaaga ggccttgagt gggtgggaag tgttgatcct gcatatggtg
      121 aaatgacgtt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      181 tggaactgag cagcctgaga tctgaggaca cggccgtata ttactgtgcg atcggcccta
      241 gcggcagttg gaacgcctgg tccttcgata tctggggccc tggcacccca atcaccatct
      301 cctcagcc
//
LOCUS       KCXD01004404             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20502:17519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004404
VERSION     KCXD01004404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20502:17519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62886.1"
                     /translation="CASNSITSGPDYW"
     D_segment       408..414
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          142 c          129 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag gcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cgcctgcagc tgcaggcggc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgg
      181 ctctatcagc ggtaactact ggagctggat ccgccgggcc ccagggaagg gactggagtg
      241 gattggatat atctacggta gtgattttac caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagcagata cgtccaagaa ccagctctcc ctgaacctgg cctctgtgac
      361 cgccgcggac acggccgtct atttctgtgc cagtaatagc ataacatctg gtccagatta
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004405             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15646:6315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004405
VERSION     KCXD01004405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15646:6315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62887.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          118 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactttg
      241 gcttacactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatctcgc
      301 atgatggcaa taacatatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatggta tatcttgaaa tggacaacct gcaattggag gacacggccg
      421 tgtatttctg tgtgagagat gcctacggta ccgggttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004406             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23296:11852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004406
VERSION     KCXD01004406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23296:11852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..484
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62888.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>488
                     /gene="IGHG"
BASE COUNT          117 a          141 c          131 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccggc tacaccttcg ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gttttgctag tatatatggt gaaataatac
      301 atacagagag attccagggc agagtcacca tgacagcgga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta cccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctccgcc
//
LOCUS       KCXD01004407             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12686:17189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004407
VERSION     KCXD01004407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12686:17189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..481
     V_segment       115..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62889.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       420..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          117 a          137 c          132 g           97 t
ORIGIN      
        1 acatggggaa caaccacatc cctcccctac agaagcccca gagcacagca cctcaccatg
       61 gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca ctctgaggtc
      121 cagctggtgc agtctggggc tgaggttaag aagcctgggg cctcagtgaa ggtctcctgc
      181 aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca ggcccctgga
      241 aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat agacgcagag
      301 aatttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc ctacttggag
      361 ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc atccagcggc
      421 acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01004408             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15954:19348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004408
VERSION     KCXD01004408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15954:19348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62890.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       441..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          109 c          153 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagct tctggattca ccttcagtag ttatggcatg
      241 cactgggtcc gcctggctcc agggaagggg ctggagtggg tggcagttac atcgtctgat
      301 gaaagtaaga aatactacgg agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tactatatct tcaaatgaac aacctgaaat tgaaggacac ggccgtgtac
      421 tactgtggga gagatgataa tggggtgatt atcgacttct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004409             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:7833:17413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004409
VERSION     KCXD01004409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:7833:17413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62891.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       419..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          140 c          137 g          104 t
ORIGIN      
        1 acatggggga gcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagctg caggtgtcca
      121 gtcccaggtc cgcctggtgc agtccgggac tgaggtgaag aagcctgggg cctcagtgaa
      181 gatttcctgc ggggcttctg gattcaccct cgacacctat ggtatcaact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg agtgatcatc ccccttattg gtatcatcaa
      301 ctacgcagag aactctcagg gcagactcac aataaccgcg aacacgtcca caaatacagc
      361 ctatatggaa ctgagcagtc tgagatctga ggacacggcc atctattact gtgcgagaga
      421 atactgtact tctagtactt gcgccgggtt ccttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004410             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9617:7317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004410
VERSION     KCXD01004410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9617:7317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..475
     V_segment       111..404
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62892.1"
                     /translation="CVRYDQWDDYLYYFDYW"
     D_segment       416..425
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>479
                     /gene="IGHG"
BASE COUNT           95 a          140 c          134 g          110 t
ORIGIN      
        1 acatggggga tgggaaatgg tctctgagag tcatgggcct cctgtgcaag aacatgaagc
       61 acctgtggtt cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc
      121 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg
      181 tctctggtga ctccatcacc aatacctact ggaactggat ccgccagccc ccagggaagg
      241 ggctggagtg gattggattt atctatggtg ctactgggag caccggctac aacccctccc
      301 tcaagagtcg agtcaccatc tcaacagaca cgtccaagaa ccagttttcc ctgaagctga
      361 gctctgtgac cgccgcggac accgccgtgt attattgtgt gagatatgat cagtgggatg
      421 attacctgta ctactttgac tactggggcc agggagtcct ggtcaccgtc tcctcgtcc
//
LOCUS       KCXD01004411             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5031:18990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004411
VERSION     KCXD01004411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5031:18990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62893.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       412..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          136 c          130 g          112 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtaact tctggatctg gatccgccag cccccaggga aggggctgga
      241 gtggataggg tctatctatg gtagtactgg gagcaccttt tacgacccct ccctcaaggg
      301 tcgagtcacc atttcaacag acacgtccaa gaacctattt tccctgaagc tggactctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat agcgatactg atagttatta
      421 cttctttgac tactggggcc agggagtccg ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004412             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:7241:14967
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004412
VERSION     KCXD01004412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:7241:14967"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    57..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        57..426
     V_segment       57..350
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <342..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62894.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       351..355
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       385..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           91 a          123 c          124 g           90 t
ORIGIN      
        1 acatggggac ctggaggctc ctctttgtgg tggcagcagc tgcaggtgtc cagtcccagg
       61 tccacctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aaaatttcct
      121 gcggggcttc tggattcacc ttcgacaccc atggtatcaa ctgggtgcga caggcccctg
      181 gacaaggact tcagtggatg ggagtgatca tcccccttat tggtatcacc aactacgcaa
      241 agaactctca gggcagagtc acactaaccg cggacacgtc cacaaacaca gcctacatgg
      301 agctgaacag cctgagattt gaggacacgg ccatctacta ctgtgcgaga gaacgctgca
      361 cttctagtgt ttgcgccggg ttccttgact cctggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01004413             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9439:22329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004413
VERSION     KCXD01004413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9439:22329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62895.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       443..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          116 c          152 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcgacct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttttggcgtc
      241 cactgggtcc gccaggctcc agggaagggc ctggagtggg tggcagttat atcgtctgat
      301 gaaagtaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaagt tggaggacac ggccgtctat
      421 tactgtgcga gagacgtata tggcagcggc tgtgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004414             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17907:10949
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004414
VERSION     KCXD01004414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17907:10949"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62896.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           91 a          137 c          133 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcagctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggaaccacct actacaaccc ctccctcaag
      301 agtcgagccg ccatttcaaa agacacgtcc aacaatcaac tctccctgag gttgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004415             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7040:13539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004415
VERSION     KCXD01004415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7040:13539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..488
     V_segment       135..426
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62897.1"
                     /translation="CATADYGNSLDYW"
     D_segment       432..443
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>491
                     /gene="IGHG"
BASE COUNT          110 a          116 c          145 g          120 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt ggcatgcact
      241 gggtccgcca gggtccaggg aaggggctgg agtgggtggc agttatatcg tctgatggaa
      301 gtttcaaata ctacgcagac tctgtgaagg gccgattcac catttccaga gacaattcca
      361 agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacactgcc ctttattact
      421 gtgcgacagc cgactacggt aacagccttg actactgggg tcagggagtc ctggtcaccg
      481 tctcctcaac c
//
LOCUS       KCXD01004416             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17761:14155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004416
VERSION     KCXD01004416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17761:14155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..452
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62898.1"
                     /translation="CGSPLNWKASW"
     D_segment       403..411
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           80 a          138 c          134 g          102 t
ORIGIN      
        1 acatggggat tgctctctgc gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg ccccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct ctcagttgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag cccccaggga aggggctgca
      241 gtggattgga tttatcggtg gtagtagtgg gatcacctcc tacaatccct ccctcaagag
      301 tcgagtcacc atttcagcag acacgtccaa gacccggttc tccctgaaac tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgggagcccc cttaactgga aagcatcttg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004417             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20696:19361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004417
VERSION     KCXD01004417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20696:19361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62899.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          123 c          159 g          110 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggtact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gctattgcaa
      301 gtggtggaga aagcacatac tatgcagact ccgtgaaggg ccgattcacc gtctccagag
      361 acaactcaaa gaacacagtc tccctgcaaa tgaacagtct tagcgcggag gacacggccg
      421 tgtattactg tgcgaatgcg ttaactgggg gtcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004418             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23243:5831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004418
VERSION     KCXD01004418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23243:5831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62900.1"
                     /translation="CARELCSSSVCAGAFDYW"
     D_segment       423..428
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          137 c          140 g          105 t
ORIGIN      
        1 acatggggat cacaaaacaa ccccatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc acctggtgca gtccgggact gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgta aggcttctgg attcaccctg gacaactatg gtgtcaactg ggtgagacag
      241 acccctggac aaggacttga gtggatgggg gtgatcatcc cccttgttgg tataattaat
      301 tacgcagaga agttccaggg cacagtcacc attaccgcgg acacgtccac agacacagcc
      361 tacatggagt tcagcagcct gagatctgag gacacggcca tctactattg cgcgagagaa
      421 ctttgtagct ctagtgtatg tgccggggcc tttgattact ggggccaggg agccctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004419             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12265:5768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004419
VERSION     KCXD01004419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12265:5768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62901.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       411..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           91 a          139 c          143 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcgggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagtaa ttggtggagc tggatccgcc agtccccagg gaagggactg
      241 gaatggattg ggggtgtcta tggtagtggt gggaataccg aatacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa ggacacgtcc aagaaccagt tctccctgaa gctgaactct
      361 gtgaccgccg cggacaccgc cgtgtattac tgtacgagag aatggggcgc tatagcggca
      421 gttgggcctg tccttgcctc ctggggccag ggtgtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004420             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20680:6398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004420
VERSION     KCXD01004420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20680:6398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62902.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       436..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          116 c          150 g          119 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag ttcgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccggtg tgaggtgcaa ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taactatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatttcgtct
      301 gatggaagta agaaatacta cgcaaactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatactcta tcttcaaatg aacaacctga aattggagga cacggccgtc
      421 tattactgtg cgagagatga tatggggacc ggttttgact actggggcca gggagtcctg
      481 gtcatcgtct cctcagcc
//
LOCUS       KCXD01004421             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15096:6716
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004421
VERSION     KCXD01004421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15096:6716"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62903.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       430..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          129 c          145 g          105 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag atgcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacagcgt caccgaatta tccattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgtaaaag gtgaaataat
      301 tcacggagag gggttccagg acagagtcac catgaccgag gacccgtcta cagacacagc
      361 ctacatggag ttgagcaacc tgagatcaga ggacacggcc gtttattatt gtgcgagtgg
      421 gtttagtatc tggttatttt acgacgttct ggattcgtgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004422             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8337:10546
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004422
VERSION     KCXD01004422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8337:10546"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..473
     V_segment       110..403
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62904.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       413..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          114 c          149 g          118 t
ORIGIN      
        1 acatggggga ggtgtttctg ttcggcgatc agcactaaac acagaacata ccatggagtt
       61 tgtgctgagc tgggttttcc ttgttgctct tttgaaaggt ttccagtgtg aggtgcacct
      121 ggtggagtct gggggcggct tggcaaagcc gggggggtcc ctgagactct cctgcgcagt
      181 ctctggattc actttcagtc actacttcat gagttgggtc cgccaggctc cagggaaggg
      241 gctggagtgg atctcaggga ttaacagtgg tggggatacc acacactatg cagactccgt
      301 gaagggcaga ttcaccctgt ccagagagaa cgccaagaac acactgtctc ttcaaatgga
      361 cggcctgaga gctgaggact cggctgtcta ttactgtgtg agagatcgac gtgtacagtc
      421 gttatcctgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004423             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:14365:12656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004423
VERSION     KCXD01004423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:14365:12656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..451
     V_segment       96..378
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62905.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       385..400
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..451
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>454
                     /gene="IGHG"
BASE COUNT          108 a          132 c          124 g           90 t
ORIGIN      
        1 acatggggaa catcacacaa caaccacatc cctcccctac agaagcccca gagtacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg cagtctgggg ctgaagtgaa
      121 gaagcctggg gcctcagtga aggtctcctg caaggtttcc ggatccacct tcaccgactt
      181 atccatgcac tgggtgcgac aggcccctgg aaaagggctt cagtggatgg gaagtgttga
      241 tcctgcatat ggtgaaatga taaacgcaga gaagttccag ggcagagtca ccatgaccga
      301 ggacacgtct acatacacag cctacatgga gctgagcagc ctgtcatctg aggacacggc
      361 cgtgtatttc tgtgcgagtg gccctagcgg cagctggaac ggctggtact tcgatttctg
      421 gggccctggc accccaatca ccgtctcctc aacc
//
LOCUS       KCXD01004424             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:17441:4692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004424
VERSION     KCXD01004424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:17441:4692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62906.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       414..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          117 a          140 c          134 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagga gcctggggcc tcagcgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagtc acagcctaca
      361 tggagttgag cagcctaaga tctgaggaca cggccctgta ttattgtgca gtcgggtata
      421 gcggccgatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01004425             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:26059:8254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004425
VERSION     KCXD01004425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:26059:8254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62907.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       426..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           99 a          145 c          134 g          107 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgtcctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggagcag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccagctactg gatcacctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatggggg cgattgatcc tagtgattct gctaccaaat
      301 acagcccgtc cttccaaggc caggtcacca tttcagccga caagtcgatc accaccgcct
      361 acctggagtg gagcagcctg aaggcctcgg acaccgccac gtattactgt gcgaaaggtc
      421 ccggagtgat tattaactac tttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004426             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6354:12652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004426
VERSION     KCXD01004426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6354:12652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62908.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          114 c          158 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtcgtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgagtcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004427             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13783:17154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004427
VERSION     KCXD01004427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13783:17154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62909.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          114 c          146 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt cttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gacactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaagtaagaa atactacgca gactttttga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctccaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004428             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4389:5509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004428
VERSION     KCXD01004428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4389:5509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62910.1"
                     /translation="CVRDAYGGGWDSW"
     D_segment       449..457
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          117 c          155 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggca ggggctggag tgggtggcgg ttatatcgtt
      301 tgatgatagt aagaaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atcttcagat gaacaacctg aaattggagg acacggccct
      421 ttattactgt gtgagagatg cttacggtgg tggctgggac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004429             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21430:3327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004429
VERSION     KCXD01004429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21430:3327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..492
     V_segment       113..404
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <398..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62911.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       414..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>496
                     /gene="IGHG"
BASE COUNT          114 a          137 c          143 g          102 t
ORIGIN      
        1 acatggggac cacgtccctc ctctaaagaa gcccctggga acacagctca tcaccatgga
       61 cttgacctgg aggctcctct ttgcggtggc agcagctaca ggtgcccagt cccaggtcca
      121 gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc tctcctgtaa
      181 ggcttctggg ttcaccttta gcaccgaagc catcaattgg gtgcgacagg cccctggaca
      241 aggacttgac tggatgggag gggtcatccc tcttatgggt acaacaaact acgcacagaa
      301 gttccagggc agagtcacgt ttaccgcgga cacgtccata agcacagcct acatggagct
      361 gagcagcctg agatctgagg acacggccgt gtattattgt gcgaaatccg tgaattacga
      421 ggaagataac ggttactata taccgacgca gtttgactac tggggccagg gagtcctggt
      481 caccgtctcc tctgcc
//
LOCUS       KCXD01004430             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:25005:10810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004430
VERSION     KCXD01004430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:25005:10810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..237
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62912.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       240..248
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>300
                     /gene="IGHG"
BASE COUNT           77 a           67 c           89 g           67 t
ORIGIN      
        1 acatggggtg cagcctctgg attcaccttc agttactatg gcatgcactg ggtccgccag
       61 gctccaggga aggggctgga gtgggtggca gttatgtcga atgatggaag taagaaatac
      121 tacggagact ctgtgaagga ccgattcacc atctccagag acaattccaa gaataggcta
      181 tatcttcaaa tgaacaacct gaaattggag gacacggcag tgtattactg tgcgagagat
      241 gatagtgggg tgatcatcga ctactggggc cagggagtcc tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01004431             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20510:17160
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004431
VERSION     KCXD01004431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20510:17160"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62913.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       404..414
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           96 a          140 c          136 g          103 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactgctga agcctttgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtaact actggagctg gatccgccag tccccaggga agggactgga
      241 gtggattgga cgtatctctg gtagtggtgg gaacaccgtc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagatc tccctgaaag tgacctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgacagcc ggatatagca gcagggaaag
      421 cttctacggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004432             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13108:18026
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004432
VERSION     KCXD01004432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13108:18026"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62914.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       414..423
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..483
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          114 a          119 c          144 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagtgtccag tgtgaggtgc
      121 acctggtgga gtctggagga ggcttggttc agccgggggg gtccctgaga ctctcctgtg
      181 cagcctctgg attcaccttc agtagctatg gcatgcactg ggtccgccag tctccagggg
      241 aggggctgga atgggtggca cttatatcgt atgatggaac taagaaatac tacgcagact
      301 ctatgaagga ccgattcacc atctccagag acaattccaa gaacatgcta tatcttcaaa
      361 tgaacgacct gaaattggag gacacggccg tctattactg tgcgagagtc agcggtataa
      421 ctgaaagttc cgttgaatac ttcgagttct ggggccaggg cgccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004433             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:26656:12953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004433
VERSION     KCXD01004433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:26656:12953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..495
     V_segment       135..425
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <417..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62915.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       428..443
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          103 a          124 c          155 g          115 t
ORIGIN      
        1 acatggggag aggagcccag cactggaagt ccacagtgtt ccattcggtg atcagcactg
       61 aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg caggtggtgg agtctggggg cggcttggca aagcctgggg
      181 gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat gctatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtctc agccattagt gttggtggta
      301 gtacatacta cgcagactcc gtgaggggcc gattcaccat ctccagagac aactcagaga
      361 gcacgctctc cctgcaaatg aacagcctga gtactgagga cacggccgtg tattactgtg
      421 ccaaagggga tacagctaca gtttattacg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004434             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17013:5246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004434
VERSION     KCXD01004434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17013:5246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..469
     V_segment       100..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62916.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       400..410
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           93 a          138 c          137 g          103 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc tttggagacc ctgtccctca cctgcggtgt ctctggtggc
      181 tccatcagca gtaactactg gagctggatc cgccagtccc cagggaaggg actggagtgg
      241 attggacgta tctctggtag tggtgggagc accgtctaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cagatctccc tgaaagtgac ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg acagccggat atagcagcag tgaaagcttc
      421 tacggtttgg attcgtgggg ccaaggggtc gtcgtctccg tctcctcagc c
//
LOCUS       KCXD01004435             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19855:14084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004435
VERSION     KCXD01004435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19855:14084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62917.1"
                     /translation="CARHGGSYYSKW"
     D_segment       402..416
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           93 a          129 c          129 g          106 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc atcaataact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctatg gtagtggtag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag atacgtccaa gaaccagttc tccctgaagt tgaactctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagacat ggtggtagtt attactcgaa
      421 gtggggccag ggagtcctgg tcatcgtctc ctcagcc
//
LOCUS       KCXD01004436             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14287:6190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004436
VERSION     KCXD01004436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14287:6190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62918.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          138 c          127 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga caggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgttt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004437             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11966:6790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004437
VERSION     KCXD01004437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11966:6790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62919.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          120 c          148 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004438             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13303:3785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004438
VERSION     KCXD01004438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13303:3785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..476
     V_segment       113..406
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62920.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       410..417
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          136 c          132 g          114 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcatggac ctcctgtgca agaacatgaa
       61 gcacctgtgg ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca
      121 gctgcaggag tcgggcccag gactggtgaa gccttcggag accctgtccc tcagctgcgc
      181 tgtctctggt gactccatca ccagtagcta ctggaactgg atccgccagc cccccgggaa
      241 gggactggag tggattgggt atatctctgg tgcttatggg agcaccagtc ataatccctc
      301 cctcaagagt cgagtcacca tttcaactga cacgtccaag aaccagtttt ccttgaggct
      361 gagttctgtg accgccgcgg acaccgccgt ctattactgt gtgagatatg aggatgaatc
      421 cattaattac cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004439             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18955:4725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004439
VERSION     KCXD01004439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18955:4725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62921.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          112 c          158 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatct
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc tatggcatgc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt gacggttatc tcgaatgatg
      301 gaggtaagaa atactacgca gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat ggcatatctt caaatgaaca acgtgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga gttgtggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004440             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9810:18193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004440
VERSION     KCXD01004440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9810:18193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62922.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          114 c          154 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa gacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tactttaaga ggtgtccagt gtgacgtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgta
      301 tgatgaaact aagaaatttt acgcagactc tgtgaaggac cgattcaccc tctccagaga
      361 caattccaag aatatgctat atcttcaaat gaacaacctg aaactggagg acacggccgt
      421 gtatttctgt gcgagagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004441             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15980:15057
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004441
VERSION     KCXD01004441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15980:15057"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62923.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       416..423
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          100 a          135 c          144 g          100 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcgtcc ctcttgttgg aacaacaaac tccgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacattc tacatggagt
      361 tgagcagcct gagatctgag gacacggcca tgtattactg tgcgagaggc ctgggtagca
      421 gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004442             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:22064:18053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004442
VERSION     KCXD01004442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:22064:18053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62924.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       417..423
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          137 c          142 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatact gtatctgatg gagtgatata
      301 cgcagaaaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattattgtg cgagaggtgt
      421 gacagcagac gtcttcggtt tcctcgggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004443             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22234:10700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004443
VERSION     KCXD01004443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22234:10700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62925.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       411..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          137 c          129 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggatctgg atccgccagc ccccagggaa gggactggag
      241 tggatagggt ctatctatgg tgctactggg agcacctttt acgacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct ggactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgcgatata gcgatactga tagttattac
      421 tactttgatt actggggcca gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004444             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11675:15308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004444
VERSION     KCXD01004444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11675:15308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62926.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       413..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           92 a          137 c          129 g          112 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcaactccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cggcaatagc tactggatct ggatccgcca gcccccaggg aaggggctgg
      241 agtggatagg gtctatctat ggtagtactg ggagcacctt ttacgacccc tccctcaagg
      301 gtcgagtcac cgtttcaaca gacacgtcca agaacctatt ttccctgact ctggactctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgcgagata tagcgatact gatagttatt
      421 acttctttga ctactggggc cagggagtcc gggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004445             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12764:10014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004445
VERSION     KCXD01004445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12764:10014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62927.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          112 c          154 g          117 t
ORIGIN      
        1 acatggggag gtctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaattc tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004446             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22621:13189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004446
VERSION     KCXD01004446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22621:13189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62928.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          117 a          145 c          136 g           94 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtga cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gacgtgaaga agcctggggc ctctgtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatatctggg gccctggcac ccctatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01004447             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7922:16465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004447
VERSION     KCXD01004447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7922:16465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62929.1"
                     /translation="CARSGSGTWNGWYLDLW"
     D_segment       421..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          138 c          139 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccagtc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctgggacct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc attcattggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaac tattgatcct ctttatggtg aaatgataca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag atacagccta
      361 catggagctg aggagcctga gatctgagga cacggccgta tattattgtg cgaggtcggg
      421 tagcggcact tggaacggct ggtacctcga tctctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01004448             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20592:8537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004448
VERSION     KCXD01004448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20592:8537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62930.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       437..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          123 c          155 g          112 t
ORIGIN      
        1 acatggggag ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacacacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccattgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct aagactctcc tgtgcagcat ccggattcag cttcagtgac cactgcatgc
      241 actgggtccg ccaggcttca gggaaggggc tggagtgggt ctcaggtatt acttatactg
      301 gtgttaccac atggtacgca gactccgtga ggggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagacc tgaggacacg gctgtctatt
      421 actgtgtggg aggaaggcgg cacgtggacc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004449             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23664:8473
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004449
VERSION     KCXD01004449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23664:8473"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62931.1"
                     /translation="CARERCTASSCAGFLDSW"
     D_segment       420..425
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          141 c          141 g           98 t
ORIGIN      
        1 acatggggac aaaacaacca catccctcct ctaaagaagc ccctgggagc acagctcatc
       61 accatggact ggacctggag gctcctcttt gtggtggcag cagctacagg tgtccagtcc
      121 caggtccagt tggtacagtc cggggctgag gtgaagaagc ctggggcctc agtgaaagtt
      181 tcctgcaagg cttctggatt caccctcgac aactatggca tcaactgggt gcgccaggcc
      241 cctggacagg ggcttgagtg gatgggagtg atcatccccc ttattggaat aataaactac
      301 gcagagaacg tccagggcag agtcgccatt tccgcggaca cgtccataaa tacagcctac
      361 atggaggtgc gcagcctgag atctgaggac acggccatct attactgtgc gcgagaacgt
      421 tgtaccgcta gcagttgcgc cggattccta gactcctggg gccagggagc cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01004450             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14784:16465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004450
VERSION     KCXD01004450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14784:16465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..505
     V_segment       124..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62932.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       426..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          141 c          147 g          104 t
ORIGIN      
        1 acatggggga cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agttggtgca gtccggggct gaggtgaaga ggcctggggc ctcagtgaag
      181 ctctcctgca aggctcctgg atacatcttc agcatatctg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcatcc ctcttgttgg tgtaacaacc
      301 tgcgcacaga agttccagga cagagtcacg attaccgcgg acacgtccac aagcacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgagtggc
      421 ggcttcgagg atgataacgg tcactattat acgacactaa catttcacga atggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004451             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13458:14478
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004451
VERSION     KCXD01004451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13458:14478"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..493
     V_segment       115..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62933.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       417..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT           99 a          140 c          139 g          117 t
ORIGIN      
        1 acatggggca gagtacatgg gggctctctg agagtcatgg acctcctgtg caagaacatg
       61 aagcacctgt ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg
      121 cagttgcacg agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc
      181 ggtgtctctg gtgtctccat caacattaac tactggagct ggatccgcca gtccccaggg
      241 aaggggctgg agtggattgg gtttatctat ggtggtgatg gctacaccac ctccaatccc
      301 tccctcaaga gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgaag
      361 ctgaagtctg tgaccgccgc ggacaccgcc gtgtattact gtgcgagata tccgcgttac
      421 gaggatgatc acggttacta ttctgtggaa attgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004452             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21420:4197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004452
VERSION     KCXD01004452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21420:4197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62934.1"
                     /translation="CAATGEPLEYFDFW"
     D_segment       406..410
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..464
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          133 c          138 g          104 t
ORIGIN      
        1 acatggggga tgttctctga tagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggagtggtga ggccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 aggatctatc agcagtggtt atgactggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtatatct atggtactag tgggagcacc aactacaatg cgtccctcaa
      301 gaatcgagtc accatttcaa aagacgcgtc caagaaccag ttctccctgc agttgaggtc
      361 tgtgaccgcc gcggacacgg ccgtttatta ctgtgcggcg acaggggaac cccttgaata
      421 cttcgacttc tggggccagg gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004453             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14344:15304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004453
VERSION     KCXD01004453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14344:15304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62935.1"
                     /translation="CATSSSGTWLYWYFDFC"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          140 c          133 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgagttatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tttctgtggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004454             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13049:10337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004454
VERSION     KCXD01004454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13049:10337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..443
     V_segment       83..376
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62936.1"
                     /translation="CARADIEAATSFDFW"
     D_segment       380..386
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          109 a          118 c          123 g           95 t
ORIGIN      
        1 acatgggaga gcacagtttc tcaccatgga cttgacctgg aagatcctcc tcttggtgac
       61 agcagccaca ggtgcccact cccaggtgca gctggtgcag tctggggctg agattaagca
      121 gcctggggcc tcagtgaaac tctcctgcaa ggcttctgga tatatctaca tggactacta
      181 catgcactgg gtgagacagg cccctggaca aggccttgag tggataggac tgatctcccc
      241 ttataatggt tacaaagggt acgcacagaa cttccaggac agagtcacca taattgcgga
      301 cacgtccacg agcacaggct acatggagct gagaagcctg agatatgagg acacaggcat
      361 ttactactgt gcgagagcag atattgaagc ggctacctcc tttgacttct ggggccaggg
      421 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004455             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:12976:8209
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004455
VERSION     KCXD01004455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:12976:8209"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62937.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          105 a          114 c          156 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctc
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgtctgatg
      301 gaagtagcat atactacgca gcctctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctg caaatgagca acctgaaatt tgaggacacg gccgtgtatt
      421 actgtgcgag agatgtgtac ggtagtgggt tagactactg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004456             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:25616:11319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004456
VERSION     KCXD01004456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:25616:11319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62938.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          141 c          133 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggttaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aatttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacttggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004457             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19628:15140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004457
VERSION     KCXD01004457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19628:15140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62939.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          121 c          157 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaggttcaa ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattagtagt
      301 ggtggggaaa gcacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactata tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tatttctgtg tgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004458             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16044:20584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004458
VERSION     KCXD01004458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16044:20584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62940.1"
                     /translation="CANALTGGLDYW"
     D_segment       436..444
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          120 c          154 g          110 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gctgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tattggatga
      241 actgggtccg ccaggctcca gagaaggggc tggagtgggt ctcagctatt actagtggtg
      301 gggatagtac atattacgca gactccgtga agggtcgatt catcatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gccttagagc ggaggacacg gccatatatt
      421 actgtgcgaa cgcgttaact ggggggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004459             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24820:5975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004459
VERSION     KCXD01004459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24820:5975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    154..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        154..517
     V_segment       154..445
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <439..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62941.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       462..472
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT           99 a          156 c          141 g          123 t
ORIGIN      
        1 acatgggggg agtctccctc accacccagc tggggatctc agtgcttcat tttctgtcct
       61 tcatttctca gtgcttcatt tctgtcctcc accacgatgg ggtcaactgc catcctcgcc
      121 ctcctcctgg ctgttctcca aggagtctgt gccgaggtgc agctggtgca gtctggagca
      181 gaggtgaaaa ggcccgggga atctctgagg atctcctgta agacttttgg atacagcttt
      241 accgattact ggatcagttg ggtgcgccag atgcccggga aaggcctgga gtggatggga
      301 atgatctatc ctagtgattc tgatcccaga tacagcccgt ccttccaagg ccaggtcacc
      361 atctcagccg acaggtccat cagcaccgcc tacctggagt ggggcagcct gaaggcctcg
      421 gacaccgcca cgtattactg tgcgagagct ggacgctaca cctacagtta cccctttgac
      481 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004460             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:15726:11520
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004460
VERSION     KCXD01004460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:15726:11520"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62942.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          119 c          148 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga gatgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004461             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5563:18517
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004461
VERSION     KCXD01004461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5563:18517"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62943.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          112 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taggaaatac tacgcagact ctgtgaagga ccaattcacc atatccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggcca
      421 cgtattactg tgtgagagat gtcaggggaa cgggatttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004462             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20561:15420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004462
VERSION     KCXD01004462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20561:15420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..513
     V_segment       138..427
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62944.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       465..471
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          111 a          122 c          161 g          121 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tatttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcacctgg tgcagtctgg gggcggcttg acaaagccgg
      181 gggggtccct gagactctcc tgtgcagcct ccggattcac cttcagtgac tactatatgg
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcacgaatc ggtcatgatg
      301 gtggtagcac atggtacgca gactccgtga agggcagatt taccatttcc agagagaatg
      361 ccaagaacac actgtttctt caaatggaca gcctgagaag tgaggacaca gccgtatatt
      421 actgtgccag agagcggttt gggggaattg gggtaattat cttcaactgg atcgatgtct
      481 ggggcccggg agtcctggtc accgtcccct cagcc
//
LOCUS       KCXD01004463             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18943:6833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004463
VERSION     KCXD01004463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18943:6833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..390
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62945.1"
                     /translation="CAKWELEQPSDDW"
     D_segment       399..408
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           92 a          141 c          132 g           92 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc actttctggt ggagctggat ccgccagccc ccagggaagg cactggagtg
      241 gattggagag atcaatggtg atagtgggag aacccactac aacccctccc tcaaaagccg
      301 actcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctggagctga cctctgtgac
      361 cgccgcggac acggccgtct attactgtgc aaaatgggag ctggaacagc cgtcagacga
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004464             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20305:11836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004464
VERSION     KCXD01004464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20305:11836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62946.1"
                     /translation="CTKDDVVVFSGPVDW"
     D_segment       445..452
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          106 a          122 c          151 g          127 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc aattggtgga gtctgggggc ggcttggcga
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactact
      241 ggatgtactg ggttcgccag gcacctggga agggcctgga gtgtatctcc gctattaatc
      301 ctgctggtgg cagcacgtac tatgcagact ccgtgaaggg cagattcacc atctccaggg
      361 agaacgccaa gaacacacta tatcttcaaa tgaacagcct gagagctgag gacacggctg
      421 tctatttctg tacgaaagat gacgttgtag tcttttctgg tcccgtagac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004465             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:7265:9965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004465
VERSION     KCXD01004465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:7265:9965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..328
     V_segment       8..263
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <256..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62947.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       270..279
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           61 a          101 c           95 g           73 t
ORIGIN      
        1 acatgggagc cttcagagac cctgtccctc acctgcgctg tctctggtgg ctccatcagc
       61 ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg gattgggttt
      121 ttcggtggta gtggtgggag cacctactac aaatcctccc tccagagtcg cgtcaccatt
      181 tcaaccgaca cgtccaagaa ccagttctcc ctaatactga cctctgtgac cgccgcggac
      241 acggccctct attactgtgc gagggggaat atagcagcga ctggcattga ctactggggc
      301 cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004466             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19967:10953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004466
VERSION     KCXD01004466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19967:10953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62948.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           90 a          139 c          131 g          102 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt gggaccacct actacaaccc ctccctcaag
      301 agtcgagccg ccatttcaaa agacacgtcc aacaatcaat tctccctgag gttgacttct
      361 ctgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004467             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9375:6171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004467
VERSION     KCXD01004467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9375:6171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62949.1"
                     /translation="CTRLHSGNYRIMMFDYW"
     D_segment       444..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          117 a          126 c          150 g          121 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgcgcagc ctctggattc accttcagtg actttgccat
      241 gagctgggtc cgccaggctt ctgggagagg actggaatgg gttgcctata ttagaagcaa
      301 atataacagt tacgcgacag aatacgccgc atcggtgaag gacagattca tcatctccag
      361 agatgattca acgagcacgc tctatctcca aatgagcagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgcacccgac tccatagtgg gaactataga attatgatgt ttgactactg
      481 gggccaggga gtcctggtca ccgcctcctc agcc
//
LOCUS       KCXD01004468             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17570:13925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004468
VERSION     KCXD01004468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17570:13925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62950.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          117 c          147 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggagtgag gtgcaactgg tggagtccgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcactaac tatggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaagaa atactacgca acctctgtga gggaccgctt caccatctcc agagacaatt
      361 ccaagaacat actttatctt caaatgaaca acctgaaatt ggaagacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004469             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14176:11203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004469
VERSION     KCXD01004469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14176:11203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62951.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       406..421
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          140 c          134 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg ctgctcccag atgggtcctg tcccagctgc atctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcaatagct actggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tctatctatg gtggtactgg gagcgccggc tacaacccct ccctcaagag
      301 tcgagtcacc gtttcaacag acacgtccaa gaaccagttt tccctgaagc tgacgtctgc
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat gaggatgaat acagtgacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004470             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22043:5793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004470
VERSION     KCXD01004470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22043:5793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..498
     V_segment       126..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62952.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       447..453
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          146 c          139 g           99 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggagggtcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccaactggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 agctcccctg caaggcttct ggatacaccc tcagcatctc taccatcagt tgggtacgac
      241 aggcccctgg acaagggctt gagtggatgg gggagatctt ccctcttgtt ggtaaaacaa
      301 aatacgcaca gaagttccac ggcagagtca cgattaccgc ggacacgtcc gcaagtacag
      361 cctacatgga gctgagcggc ctgaaatctg aggacacggc cgtctattac tgtgcgaaaa
      421 gaggtggcca cggtaccacc accacgttgt acttctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004471             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19327:18902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004471
VERSION     KCXD01004471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19327:18902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62953.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          109 c          157 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtatc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaagtaagaa atactacaca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaaaat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgcgcgag agacgatttt ggcagcggct tagggtactg gggccaggga gccctggtga
      481 ccgtctcttc agcc
//
LOCUS       KCXD01004472             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13162:15966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004472
VERSION     KCXD01004472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13162:15966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..499
     V_segment       119..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62954.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       419..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>505
                     /gene="IGHG"
BASE COUNT          112 a          137 c          146 g          110 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccacctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaagctctc
      181 ctgcaagact tctggataca ccttcagcat ctctgccatc agttgggtgc gacaggcccc
      241 tggacaaggg cttgggtgga tgggagggat catccctctt gttggtgtga caaactacga
      301 acagaagttc cagggcagag tcacgattac cgcggacacg tccacgaata cagtcttcat
      361 ggaactgagc agcctgagat ctgaggacac ggccgtctac tattgtgcga caggggtata
      421 ttaccaggat gaatacggtt atttttatgt cggcggtgac tttgactact ggggccaggg
      481 agtcctggtc accgtctccc cagcc
//
LOCUS       KCXD01004473             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21471:7348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004473
VERSION     KCXD01004473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21471:7348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62955.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          115 c          152 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcgccctg
      181 gggggtccct gagactctcc tgtgcagcct ctggatttac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttttg tcgtctgatg
      301 gaggttacaa ataccacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccagaaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01004474             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:25601:18238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004474
VERSION     KCXD01004474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:25601:18238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62956.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       441..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          113 c          149 g          115 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctgttttaa
      121 gaggtgtcca gtgtgaggta cagctggtgg agtctggagg agacttggtt cagccggggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat ggcatacact
      241 gggtccgcca ggctccaggg aaggggctgg ggtgggtggc agttatatcg tctgatggaa
      301 gtaagacata ctacgcaaac tctgtgaagg accgattcac catattaaga gacaattcca
      361 agagcatgct ctatcttcaa atgaacaacc tgaaattgga ggacacggcc gtctattact
      421 gtgcgagaga cgatatggga agtggctttg actactgggg cccgggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004475             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19821:3389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004475
VERSION     KCXD01004475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19821:3389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    17..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        17..378
     V_segment       17..310
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <302..>346
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62957.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       311..315
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       331..378
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           80 a           95 c          125 g           80 t
ORIGIN      
        1 acatggggtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
       61 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      121 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      181 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      241 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      301 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctgggggc cagggcgccc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004476             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18089:5919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004476
VERSION     KCXD01004476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18089:5919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62958.1"
                     /translation="CVRESYSGNYYFNRFDVW"
     D_segment       403..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          135 c          134 g          111 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccagta gcaataatta ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac atatctctgg tagtggtggg aggaccgact acaacccctc cctccagagt
      301 cgagtcacca tttcaactga cacgtccaag agccagttct ccctgaagtt gagctctgtg
      361 accgccgcgg acacggccgt ctattactgt gtaagagagt catatagtgg taattattac
      421 ttcaaccggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004477             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:9976:13637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004477
VERSION     KCXD01004477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:9976:13637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..466
     V_segment       94..390
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <382..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62959.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       402..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           91 a          136 c          141 g          100 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcggga gtcgggccca
      121 gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 accagtagta attggtggag ctggatccgc cagtccccag ggaagggact ggaatggatt
      241 gggggtatct atggtagtgg tgggaatacc gaatacaacc cctccctcaa gagtcgagtc
      301 accatttcaa aggacacgtc caagaaccag ttctccctga agctgaactc tgtgaccgcc
      361 gcggacaccg ccgtgtatta ctgtacgaga gaatggggcg ctatagcggc agttgggcct
      421 gtccttgcct cctggggcca gggtgtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004478             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7382:17999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004478
VERSION     KCXD01004478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7382:17999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62960.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          113 c          154 g          120 t
ORIGIN      
        1 acatggggag gggctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tatgatgaaa caaagaaatt ctacgcagac tctctgaagg accgcttcat catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaataacc tgaaattaga ggacacggcc
      421 gtatatttct gtgtgagaga tgtcagggga acggggtttg acttctgggg ccagggtgtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004479             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14496:11031
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004479
VERSION     KCXD01004479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14496:11031"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62961.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       438..443
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          151 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttactattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tttggcatcc
      241 actgggtccg ccaggctcca gggcaggggc tggactgggt ggcagttata tcgaatgatg
      301 gaagtaaaaa atactaccca gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccgaggccaa tgtatatctt caaatgaata acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agatgcgtat ggttccggct tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004480             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:8869:15150
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004480
VERSION     KCXD01004480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:8869:15150"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..468
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62962.1"
                     /translation="CTRRPWNADYFDYW"
     D_segment       411..417
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          109 a          103 c          137 g          121 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtacaat
      121 tggtggagtc tggaggaggt ttgggtcagc ctggggggtc cctgagactc tcctgtgaag
      181 cttctggatt catcttcagt aattatggca tgcactgggt ccgccaggct ccagggaagg
      241 ggctggagtg ggtggcagtt atatcgtatg atgtaagtaa gacatactac gcagactctg
      301 tgaaggaccg attcaccatc tccagagaca attctaagaa catgctatat cttcaaatga
      361 gcaacctgaa attggaggac acggccgtgt atttctgtac gagacgccct tggaacgctg
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004481             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20696:5513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004481
VERSION     KCXD01004481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20696:5513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..317
     V_segment       9..232
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <224..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62963.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       236..246
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       268..317
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           68 a           86 c           94 g           71 t
ORIGIN      
        1 acatggggct tctggataca gcttcagcat ctatgtcatc agttgggtgc gacaggcccc
       61 tggacaaggg cttgagtgga tgggaggcat cttccctctt gttggtacaa caaactacgc
      121 acagaagttc cagggcagag tcacgattac cgcggacacg gccacaagca cagcctacat
      181 ggacctgagc agcctgggat ctggggacac ggccgtgtat tattgtgcga gaggttactg
      241 tactggcaat ggttgtaacc ttactttcaa ccggctcgat gtctggggcc cgggagtccc
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004482             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6557:7656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004482
VERSION     KCXD01004482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6557:7656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62964.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          121 c          151 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagactggag gacgcggccg
      421 tctattactg tgcgagagga gactacggta acagccttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01004483             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12343:9468
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004483
VERSION     KCXD01004483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12343:9468"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62965.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       415..421
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          144 c          129 g          106 t
ORIGIN      
        1 acatggggac tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcgcctgcg ctgtttctgg
      181 tgactccatc aacagtggct actactggag ctggatccgc caacccccag agaaggggct
      241 ggagtggatt gggtttttcg gtggtagtag tggtagcacc tactacaacc cctccctcaa
      301 gagtcgagtc accctttcaa aagacacgtc caggaaccag ttctccctga aactgacctc
      361 tgtgaccgcc gcggacacgg ccgtctatta ctgtgcgaga aaacttccag gtctgcaact
      421 aaccggtttc gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004484             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24616:8864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004484
VERSION     KCXD01004484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24616:8864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62966.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          116 a          142 c          130 g           93 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta taggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctacact gggtgcgaca
      241 ggctcctggg aaaggacttg agtggatggg aggtgttcat cctgaatatg gaaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01004485             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12224:8349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004485
VERSION     KCXD01004485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12224:8349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62967.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       415..420
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           92 a          142 c          132 g          105 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcagggg
      121 tcgggcccag ggctggtgaa gccttcggag accctgtccc tcacctgcgc tgtttctggt
      181 gactccatca acagtggcta ctactggagt tggatccgcc aacccccagg gagggggctg
      241 gagtggattg ggtctatcgg tggtagtagt ggcagcacct actacaaccc ctccctcaag
      301 agtcgagtca ccctttcaaa agacacgtcc aggaaccagt tctccctgaa actgagctct
      361 gtgaccgccg cagacacggc cgtttattac tgtgcgagaa aacttccagg tctccaacta
      421 accggtttcg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004486             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2861:14691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004486
VERSION     KCXD01004486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2861:14691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62968.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          113 c          149 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggacggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaata acctgaaatt ggaggacacg gccatttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01004487             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:8543:10489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004487
VERSION     KCXD01004487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:8543:10489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62969.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       401..408
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           80 a          138 c          133 g          113 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cgattacttc tggaactggg tccgccagtc cccagggagg gggctggagt
      241 ggattggatt tttctatggt gctactggga gcaccggcta caacccctcc ctcaagagtc
      301 gagtcacctt ttcagcagac acgtcccaga accagttttc cctgaggctg acctctgtga
      361 ccgccgcgga caccgccgtt tattattgtg cgagatatca gggtgattcc ttgtactact
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004488             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13921:12222
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004488
VERSION     KCXD01004488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13921:12222"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62970.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       427..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          135 c          148 g          104 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgga gtccggggct gaggtgaaga agcctggggc ctcagcgaag ctctcctgca
      181 aggccgctgg atacattttc agtacctctg ccatcagttg gctgcgacag gcccctggac
      241 aagggcttga gtggatgggg gggatcatgc ctcttgttgg tagaacaaac tacgcacaga
      301 ggttccaggg cagagtcacg attaccgcgg acacgtccac aaggacagcc aacatggagc
      361 tgagcagcct gacatctgag gacacggccg tgtattactg tgcgagcggt ggtttccagg
      421 atgagaacgg ttactatttt ccagactatt ttgacttttg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004489             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20509:9059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004489
VERSION     KCXD01004489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20509:9059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62971.1"
                     /translation="CARHHLEWLSFDYW"
     D_segment       405..413
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           92 a          136 c          130 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtccagtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatctac agtacctact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atctatggtg gtagtgggag caccggctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttac gtgaaactga actctgtgac
      361 cgccgcagac accgccgtct attactgtgc gaggcaccac ttggagtggt tatcttttga
      421 ctactgggga cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004490             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18052:7462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004490
VERSION     KCXD01004490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18052:7462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..492
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62972.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       439..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>498
                     /gene="IGHG"
BASE COUNT          113 a          115 c          150 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtacaattg gtggagtctg gaggaggttt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagct tctggattca ccttcagtaa ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtatgat
      301 gtaagtaaga aatactacgc agactctgtg caggaccgat tcaccatctc cagagacaat
      361 tctaagaaca tgctacatct tcaaatgagc aacctgaaat tggaggacac ggccgtgtat
      421 ttctgtgcga gacgcccttg gaacgctgac tactttgact actggggcca gggagtcctg
      481 gtcaccgtct ccgcagcc
//
LOCUS       KCXD01004491             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22514:13714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004491
VERSION     KCXD01004491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22514:13714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..466
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62973.1"
                     /translation="CARDESAINYPFDYW"
     D_segment       414..420
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          136 c          133 g          104 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcacg gacatcctgt gcaagaacat gaagtatctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaaggcttca gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tcagaagtca ctggtggagt tggatccgcc agcccccagg gaagggactg
      241 gagtggattg gacgtgtctc tggtagtggt ggcatcacca tctacaagcc ctccctcaag
      301 agtcgagtca ccatttcaac agaaacgtcc aagaatcagt tctccctgaa gctgacctct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgagagcgc cattaactac
      421 ccttttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004492             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16585:8133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004492
VERSION     KCXD01004492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16585:8133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..486
     V_segment       117..410
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62974.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       425..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          115 a          140 c          137 g           96 t
ORIGIN      
        1 acatggggac ccaacaacaa cacccctcca cagaagcccc tggatcacag ctccttgcca
       61 tggactggac ctggaggatc ctcttcttgg tggcagcagc aacaagtgcc cactcccagg
      121 tgcagctggt gcagtcgggg gctgaggtga agcagccggg gacatcagtg aaggtctcct
      181 gcaaggcttc tggctacacc ttcactagct atggtatgaa ctgggtgcga caggcccagg
      241 gacaacggct tgagtggatg ggatggctca acaccgacac tgggaaccca acgtatgccc
      301 agggcttcaa agaacgattt acattctcca tggacacctc tatgaccacg gcatatctgc
      361 agatcagcag cctaaagact gaggacacgg ccgtatacta ctgtgcaaga agtttgggct
      421 ggcatgatta taatgacgtc gcccttgact tctggggcca gggagtcctg gtcgccgtct
      481 cctcagcc
//
LOCUS       KCXD01004493             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8045:11019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004493
VERSION     KCXD01004493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8045:11019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62975.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>511
                     /gene="IGHG"
BASE COUNT          117 a          149 c          142 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct ccgtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gttaatggtg acctaataca
      301 cgcagacaag ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga catggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag tctcttcagc c
//
LOCUS       KCXD01004494             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19803:7576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004494
VERSION     KCXD01004494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19803:7576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62976.1"
                     /translation="CTRIWCPRDLTSGCNWFDVW"
     D_segment       457..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          104 a          129 c          159 g          125 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggagcacct cgtggagtct gggggaggcc tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagg ctctggattc atctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaggggg actggagtgg gtctcgtcca ttagtaacac
      301 tggtaaaagt atatactaca ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgcccagaac tcggtgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaatttggt gtccccgcga tttaaccagc ggctgtaatt ggttcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004495             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:27759:13376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004495
VERSION     KCXD01004495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:27759:13376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..474
     V_segment       108..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62977.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       413..419
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..474
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          109 a          135 c          134 g           98 t
ORIGIN      
        1 acatggggac atccctcccc tacagaagcc ccagagcaca gcacctcacc atggactgga
       61 cctggaggat cctcctcttg gtggcagcag ctgcaggcgc ccgctctgag gtccagctgg
      121 tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcgaggttt
      181 ccggatatac cttcaccgaa ctgtccattc attgggtgcg acaggcccct ggaaaaggcc
      241 ttgagtggat gggaagtgtt gatcctgaat atggtgaaat gataaacgca gaaaaattcc
      301 agggcagagt caccttgacc gaggacacgt ctacaggaac ggcctacatg gacctgatca
      361 gtctgagatc tgaagacacg gccgtgtatt actgtgcgac atcacccagc ggcacctggc
      421 tatattggta cttcgatttc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01004496             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22378:13165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004496
VERSION     KCXD01004496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22378:13165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62978.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          115 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc ccgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004497             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9463:18814
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004497
VERSION     KCXD01004497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9463:18814"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62979.1"
                     /translation="CGRDYNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          110 c          151 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gatccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agattataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004498             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19981:7815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004498
VERSION     KCXD01004498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19981:7815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62980.1"
                     /translation="CSRDPVDCSGSDCYAFDYW"
     D_segment       425..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          120 a          137 c          134 g          104 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagt tggtgcagtc tggggctgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata tagattcact gactaccaca tgcactggat gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt acaatggtta caaagcctac
      301 gcacagaact tccagggcag agtcaccata agtgcggaca cgtccacgag cacaggctac
      361 atggagctga gcagcctgag atctgaggac acagccgtgt attattgttc gagagaccca
      421 gttgactgta gtggtagtga ttgctacgcc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004499             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11579:18288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004499
VERSION     KCXD01004499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11579:18288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62981.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       407..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          131 c          137 g          114 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcatatgcgc tgtctctgga
      181 ggctctatca gcggtggtta tgactggagc tggatccgcc agcccccagg gaggggactg
      241 gagtggattg ggtatatcta tggtagtcgt gggggcgcca cctacaaccc gtccctcaag
      301 aatcgagtca ccatctcaaa agacacgtcc aagaaccagt tgtccctgaa gctgaactct
      361 gtgaccgccg cggacacggc cgtatattat tgtgcgagac agtgttgtta ctatgatgac
      421 tttttagact actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004500             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15713:16115
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004500
VERSION     KCXD01004500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15713:16115"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62982.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       424..431
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          104 a          137 c          146 g          100 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga tgtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag gcttctggat tcgccttcag aatgtatgcc ctcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gatcgtccct cttgttggaa caacaaactc
      301 cgcacagaag ttccagggca gagtcacgat taccgcggac acgtccacaa gcacagtcta
      361 catggagttg agcagcctga gatctgagga cacggccatg tattactgtg cgagaggcct
      421 gggtagcagc gcccactttg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01004501             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10310:15883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004501
VERSION     KCXD01004501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10310:15883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62983.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          115 a          141 c          129 g           96 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagttggtac agtctggggt tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc cagtcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01004502             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22519:9133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004502
VERSION     KCXD01004502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22519:9133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62984.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       416..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          143 c          137 g           91 t
ORIGIN      
        1 acatgggaga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ctttctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccc tcaccgaagt gtccactcac tgggtgcgac
      241 aggcccccgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc tacatggaat
      361 tgagcagcct aagatctgag gacacggccg tgtattactg tgcgattgga cctaccggca
      421 ggtggaacgg ctggtccttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01004503             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17746:9631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004503
VERSION     KCXD01004503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17746:9631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..395
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62985.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       406..411
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT          105 a           98 c          148 g          109 t
ORIGIN      
        1 acatggggag agatcgagtg ggagtggaca tgagtaagag aaacagtgga tatatgtggc
       61 agtttctgac cttggtgtct ctctatttgc aggtgtccag tgtgaggtgc agctggtgga
      121 gtctggagga cacttggttc agcctggggg gtccctgaga ctctcctgtg cggcctctgg
      181 attcaccttc agtacctatg gcatgcactg ggtccgccag gctccaggga aggggctgga
      241 gtgggtggcg gttatatcga atgatgaaag taagaaatac tacggagact ctgtgaaggg
      301 ccgattcagc atctccagag acaattcgaa gaacatgcta tatcttcaaa tgaacaccct
      361 gaaattggag gacacggccg tgtattactg tgcgacagat gcgtttggta gcgggattga
      421 ccactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004504             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6455:20067
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004504
VERSION     KCXD01004504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6455:20067"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..505
     V_segment       124..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62986.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       426..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          141 c          145 g          106 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agttggtgca gtccggggct gaggtgaaga ggcctggggc ctcagtgaag
      181 ctctcctgca aggctcctgg atacatcttc agcatatctg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcatcc ctcttgttgg tgtaacaacc
      301 tacgcacaga agttccagga cagagtcacg attaccgcgg acacgtccac aagcacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgagtggc
      421 ggcttcgagg atgataacgg tcactattat acgacactaa catttcacga ttggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004505             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16587:17321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004505
VERSION     KCXD01004505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16587:17321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..505
     V_segment       133..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62987.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       443..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          106 a          122 c          153 g          126 t
ORIGIN      
        1 acatggggag acaggagtct tagccctgga ttccaagaac ttccactttg ggatcagctc
       61 tgaacacaga ggaccatgga gttggggctg agctgggttt tccttgttgc tattttaaaa
      121 ggtgtccagt gtgaggtgga gctggtggag tctgggggag gcttggtcca gcctgggggg
      181 tccctgagac tctcctgtgt agcctctgga ttcacctttg gtgactatgg catgcactgg
      241 gtccgccagg ctccgggaaa gggactggag tgggtctcat ccattagaaa cactggtaaa
      301 atcgtatact acgctgactc cgtgaagggc cgattcatca tctccagaga caacgccaag
      361 aattcgctgt ctctgcaaat gagcagcctg agagtcgagg actcggccgt ctattactgt
      421 actagaattg gcgtcggatc tctagcaccg gctggtgaat actttgacta ctggggccag
      481 ggagtcctgg tcaccttctc ctcagcc
//
LOCUS       KCXD01004506             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7964:15140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004506
VERSION     KCXD01004506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7964:15140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..476
     V_segment       110..404
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62988.1"
                     /translation="CATRAPRWFYDSDHKW"
     D_segment       431..436
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          144 c          137 g          101 t
ORIGIN      
        1 acatggggat gggaaatgtt ctctgagagt cacggacctc ctgtgcaaga acatgaagca
       61 cctgtggttc ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct
      121 gcaggagtcg ggcccaggac tggtgaagcc ttcggagacc ctgtccctca catgcgctgt
      181 ctctggtgac tctatcacca gtactaactg gtggacctgg atccgccagc ccccagggaa
      241 agggctggag tggattgggt atatcagtgg taggagcggt agcacctcct acaacccctc
      301 cctcaagagt cgagccatca tttcaacaga cacgcccaag aaccagttct ccctgcagct
      361 gagctctgtg accgccgcgg acacggccgt gtattattgt gcgactaggg ccccccgatg
      421 gttctatgac agtgatcaca agtggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004507             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21549:14160
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004507
VERSION     KCXD01004507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21549:14160"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62989.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       419..425
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          113 a          139 c          136 g          100 t
ORIGIN      
        1 acatgggaca cacaacagcc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctgcaggc gcccgctctg
      121 aggttcagtt ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcgaggt ttccggatac accttcaccg aactgtccat ccactgggtg cgacaggccc
      241 ctggaaaagg ccttgagtgg atgggaagtg ttgatcctga atatggtgaa atgataaacg
      301 cagaaaagtt ccagggcaga gtcaccttga ccgaggacac gtctacagga acggcctaca
      361 tggagctgat cagcctgaga tctgaagaca cggccgtgta ttactgtgcg acatcaccca
      421 gcggcaattg gcttttttgg tacttcgatt tttggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01004508             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:7997:2090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004508
VERSION     KCXD01004508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:7997:2090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62990.1"
                     /translation="CATGPSGTWNAWCLDFW"
     D_segment       414..424
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          108 a          141 c          134 g           94 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgagggtc
      181 tcctgcaagg tttccggata caccttcacc gaattatcca tacactgggt gcggcaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc tatatggtga aatgaagttc
      301 cagggcagag tcaccatgac cgaggacacg tctgcagaca cagcctacat ggaactgagt
      361 agtctgacat ttgaggacac ggccgtgtat tactgtgcga ctggccctag cggcacctgg
      421 aacgcctggt gcctcgattt ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01004509             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22999:6485
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004509
VERSION     KCXD01004509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22999:6485"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62991.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          153 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggga gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004510             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20979:11269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004510
VERSION     KCXD01004510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20979:11269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62992.1"
                     /translation="CARGVTPDVFGFFGLGYW"
     D_segment       415..420
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          139 c          143 g           99 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgca gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaaag tttccggata caccttcacc gatttatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgatactg tatctgatgg agtgatatac
      301 gcagagaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggtgtc
      421 acaccagacg tcttcggttt cttcgggctt ggctactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01004511             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15287:19895
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004511
VERSION     KCXD01004511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15287:19895"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62993.1"
                     /translation="CVRDSSGSGFDRW"
     D_segment       445..450
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          112 c          153 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtactttt
      241 ggcatacact gggtccgcct ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tacgatgaaa ataagaaata ctatggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcac atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga ttcaagcggt tcgggatttg accgttgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004512             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6410:3741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004512
VERSION     KCXD01004512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6410:3741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62994.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       441..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          114 c          151 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtccagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cagtttcagc aactctggca
      241 ttcactgggt ccgccaggct ccaggggagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgaaagtaa gacatactac gcagactctg tgaaggaccg attcaccatt tccagagaca
      361 attccaagaa catggtacat cttcaaatga acaccctgaa tttggaggac acggccgtat
      421 attactgtgt gagagattct tacggtagag gctttgacca gtggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004513             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:22846:4477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004513
VERSION     KCXD01004513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:22846:4477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62995.1"
                     /translation="CAGDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          119 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgggagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004514             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9904:15605
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004514
VERSION     KCXD01004514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9904:15605"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62996.1"
                     /translation="CAAGYSGRWNQWYFDLW"
     D_segment       418..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          145 c          141 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcaac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga aacctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggcgttgatc ctgcatatgg tgaatttaca
      301 cccggagagg agttccaggg cagagtcacc atgaccgagg acacgtctat agacacagcc
      361 tacatggagc tgagcagcct gaactctgag gacacggccg tctattactg tgcagccggg
      421 tatagcggcc gctggaacca gtggtacttc gatctctggg gccctggcac cccaatcacc
      481 atctcgtcag cc
//
LOCUS       KCXD01004515             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8796:14012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004515
VERSION     KCXD01004515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8796:14012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62997.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga gtcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattattg tgcgagagga gactacggta acagccttga cttctggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01004516             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20140:7544
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004516
VERSION     KCXD01004516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20140:7544"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62998.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       412..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          113 a          141 c          129 g           91 t
ORIGIN      
        1 catggggaca caaccaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggct cctcctcttg gtggcagcag ctacaggcgc ccactccgag
      121 gtccagctgg tacagtctgg ggctgaggtg aagaagcctg gggcctccgt gaaaatctcc
      181 tgccaggctt ctggatacac cttaaccgac cactacctac actgggtgcg acaggctcct
      241 gggaaaggac ttgagtggat gggaggtgtt catcctgaat atggaaaagt agactacaca
      301 cagaagttcc aagacagagt caccatcacc gcggacatgt cgacagagac agtctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtttatt actgtgtgac agtgggtccc
      421 taccattact ttgacttctg gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004517             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18864:10327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004517
VERSION     KCXD01004517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18864:10327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX62999.1"
                     /translation="CVRESYSGNYYFNRFDVW"
     D_segment       401..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          135 c          134 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccagtagc aataattact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacat atctctggta gtggtgggag gaccgactac aacccctccc tccagagtcg
      301 agtcaccatt tcaactgaca cgtccaagag ccagttctcc ctgaagttga gctctgtgac
      361 cgccgcggac acggccgtct attactgtgt aagagagtca tatagtggta attattactt
      421 caaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004518             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24025:16783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004518
VERSION     KCXD01004518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24025:16783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..494
     V_segment       134..427
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63000.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       428..432
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..494
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          106 a          123 c          153 g          114 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc gatcagcact
       61 aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa agcctggggg
      181 gtccctgaga ctctcctgcg cagcctctgg attcaacttc aattactact acattaactg
      241 ggtccgccag gctccaggga aggggctgga gtggatctca ggtattgaca gtggtggaca
      301 tagcacatac tatgcggact ccgtgaaggg cagattcacc atctccagag agaacgccaa
      361 gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg tctattactg
      421 tgcgagagtg gtgggtggtg ccgcaggata cttcgacttc tggggccagg gcgccctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004519             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20067:16269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004519
VERSION     KCXD01004519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20067:16269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63001.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       431..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          114 c          148 g          117 t
ORIGIN      
        1 acatgggggg gagaggaacc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt attgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtagc tatggcttgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtctgatg
      301 aaagtaggaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccatgtatt
      421 actgtgcgag ggatgataat ggggtgctca tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004520             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22727:11257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004520
VERSION     KCXD01004520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22727:11257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63002.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          140 c          134 g           95 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtgcttcgat atctggggcc ctggcacccc gatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01004521             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13226:20958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004521
VERSION     KCXD01004521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13226:20958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..390
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63003.1"
                     /translation="CARWGDSQSIYYFDYW"
     D_segment       391..398
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>462
                     /gene="IGHG"
BASE COUNT           91 a          131 c          134 g          106 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg tggctctatt
      181 agcagtagta actggtggaa ctggatccgc cagcccccag ggaaagggct ggagtggatt
      241 gggtatatca gtggtgctag tggtagtacc gactatcacc cctccctcaa gagtcgagtc
      301 accatttcaa cagacacgtc caagaaccag tttaccctga agttgagctc tgtgaccgcc
      361 gcggacacgg ccgtgtatta ctgtgcgaga tggggtgact cccagtccat ttactacttt
      421 gactactggg gccagggagt cctggtctcc gtctccttag cc
//
LOCUS       KCXD01004522             425 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11764:8142
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004522
VERSION     KCXD01004522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 425)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 425)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11764:8142"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..423
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..423
     V_segment       69..362
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>392
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63004.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       368..374
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       380..423
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        424..>425
                     /gene="IGHG"
BASE COUNT           92 a          100 c          126 g          107 t
ORIGIN      
        1 acatgggcac catgaagttt gggctgagct gggttttcct tgttgctatt ttaagaggtg
       61 tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct ggggggtccc
      121 tgagactctc ctgtgcagcc tctggattca ccttcagtac ctctggcatg cactgggtcc
      181 gccaggctcc agggaagggg ctggagtggc tgacagttat atcgtatgat gaaactaaga
      241 aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat tccaagaaca
      301 tgctatatct tcaaatgaac aacctgaaat tggaggacgc ggccgtgtat tactgtgcga
      361 gagattctta cggtcgaggc tttgactcct ggggccaggg agtcctggtc accgtctcct
      421 cagcc
//
LOCUS       KCXD01004523             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12816:16099
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004523
VERSION     KCXD01004523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12816:16099"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..293
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..293
     V_segment       8..219
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <212..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63005.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       226..241
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       243..293
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        294..>295
                     /gene="IGHG"
BASE COUNT           74 a           80 c           82 g           59 t
ORIGIN      
        1 acatgggacc ttcaccgaat tatccataca ctgggtgcga caggcccctg gaaaagggct
       61 tgagtggatg ggaagtgttg atcctttata tggtgaaatg atacacacag aacagttcca
      121 gggcagagtc accctgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag
      181 cctgagatct gaggacacgg ccgtgtatta ctgtgcgagt ggccctagcg gcagctggaa
      241 cgactggtac ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01004524             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18865:3321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004524
VERSION     KCXD01004524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18865:3321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63006.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       401..416
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           92 a          142 c          131 g          102 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtacc tactggagct ggatccgcca gcccccagga aagggactgg
      241 agtggattgg acgtatctct ggtggtggtg ggaacaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaga gacacgtcca ggaaccagtt ctccctgcag ctgaattatg
      361 taaccgccgc ggacacggcc gtgtatttct gtgccagaac tagcggtggc tggtccccct
      421 actttgacta ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004525             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22048:19447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004525
VERSION     KCXD01004525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22048:19447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63007.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          105 a          125 c          155 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttaatggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggatt ggatctcagg tattaacggt
      301 ggtggggata ccacctacta tgcagactcc gtgaagggca gatccaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004526             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13842:4619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004526
VERSION     KCXD01004526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13842:4619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..467
     V_segment       105..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63008.1"
                     /translation="CARWAEDDYGYFRFDYW"
     D_segment       400..419
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          136 c          136 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaacc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caagtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtagtttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtct atgtatgggg gtagtgggag caccacctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga gttctgtgac
      361 cgccgcggac accgccgtct attactgtgc gagatgggcc gaggacgatt acggttactt
      421 tagatttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004527             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8783:5620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004527
VERSION     KCXD01004527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8783:5620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63009.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           83 a          137 c          141 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggccctg gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggggctgg atccgccggc ccccagggaa ggggctggag
      241 tggattgggt atatcagtgg gagtagtggg agcaccgact acaagtcctc cctccagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctggagtt gagttctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtcc ggggcgttac tatccactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004528             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13047:10401
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004528
VERSION     KCXD01004528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13047:10401"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63010.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          121 c          150 g          115 t
ORIGIN      
        1 acatgggggg gacaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattccc cttcagtagc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtcatt tcgtacgacg
      301 aaactaagaa atactacgca gactctctgg aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt cagatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgcg gaggccctgg agtgcagatg cctttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01004529             355 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:7975:2928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004529
VERSION     KCXD01004529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 355)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 355)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:7975:2928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..353
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..353
     V_segment       8..278
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>322
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63011.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       292..298
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..353
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        354..>355
                     /gene="IGHG"
BASE COUNT           88 a           92 c          101 g           74 t
ORIGIN      
        1 acatgggggg gctgaggtga agaaccctgg ggcctcagtg aaggtctcct gcaaggtttc
       61 cggatacatc ttaaccgaat tatccataca ctgggtgcga caggcccctg gaaaagggct
      121 tgagtggatg ggaagtgttg atcctcaata tggtgaaatg atagacgcag agaaattcca
      181 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacttgg agctgagcag
      241 tctgagatct gaggacacgg ccgtgtatta ctgtgcgacc tcatccagcg gcacctggct
      301 atactggtac ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01004530             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22457:6933
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004530
VERSION     KCXD01004530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22457:6933"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..505
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63012.1"
                     /translation="CATGVFYQDEYGSFYFGGDFDSW"
     D_segment       428..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          108 a          139 c          146 g          114 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cctctggata caccttcagc atctctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgggtg gatgggaggg atcatccctc ttgttggttt gacaaactac
      301 gaacagaagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      361 atggagctga gcagcctgag atctgaggac acggccgtct attattgtgc gacaggggta
      421 ttttaccagg atgaatacgg ttctttttat ttcggcggtg actttgactc ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004531             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19399:8816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004531
VERSION     KCXD01004531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19399:8816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..468
     V_segment       114..407
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63013.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       420..426
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          111 a          108 c          136 g          115 t
ORIGIN      
        1 acatggggtc cacagtgttc cattcggtga tcagcacaga acacagagga ctcaccatga
       61 agtttgggct gagctgggtt ttccttgttg ctgttttaag aggtgtccag tgtgaggtcc
      121 agctggtgga gtctggagga gacttggttc agcctggggg gtccctcaga ctctcctgtg
      181 cagcctctgg attcaccttc agtaactatg gcatacactg ggtccgccag gctccaggga
      241 aggggctgga gtgggtggca gttatatcgt ctgatggaag taagacatac tacgcaaact
      301 ctgtgaagga ccgattcacc atattaagag acaattccaa gaacatgcta tatcttcaaa
      361 tgaacaacct gaaattggag gacacggccc tctattactg tgcgagagac gatatgggaa
      421 gtggctttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004532             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16848:6911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004532
VERSION     KCXD01004532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16848:6911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..494
     V_segment       146..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63014.1"
                     /translation="CARADRGSSIDYW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          113 a          117 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagttgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtggggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaacctatg
      241 gcctgcactg ggtccgccag gccccaggga aggggctgga gtgggtggcg gttatatcat
      301 atgatgatga caagaaatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttttattg tgcgagagcg gatcgcggca gttcaattga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01004533             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17669:16832
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004533
VERSION     KCXD01004533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17669:16832"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63015.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          115 c          153 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggta cagctggtgg agtctggagg agacttggtt
      181 caccctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca gggtccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaggacata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgat atttcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtccccg tctcctcagc c
//
LOCUS       KCXD01004534             286 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22640:9140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004534
VERSION     KCXD01004534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 286)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 286)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..286
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22640:9140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..284
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..284
     V_segment       4..226
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>253
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63016.1"
                     /translation="CARWSAANFDSW"
     D_segment       231..237
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..284
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        285..>286
                     /gene="IGHG"
BASE COUNT           59 a           82 c           85 g           60 t
ORIGIN      
        1 acatgggggc tccatccgca gtggttatgg ctggagctgg atccgccagc ccccagggaa
       61 ggggctggag tggattggat gtatctatga tagtagtggg aacacctact acaacccctc
      121 cctcaagagt cgagtcacca tttcaatgga cacgtccaag aaccagttct ccctggagct
      181 gaggtctatg accgccgcgg acacggccgt gtatcactgt gcgagatggt cggcagccaa
      241 ctttgactcc tggggtcagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004535             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8318:12929
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004535
VERSION     KCXD01004535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8318:12929"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..445
     V_segment       91..384
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <376..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63017.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       385..390
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..445
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          105 a          130 c          125 g           87 t
ORIGIN      
        1 acatggggaa gccccagagc acagcacctc accatggact ggacctggag gctcctcctc
       61 ttggtggcag cagctacagg cgcccactcc gacgtccagc tggtacagtc tggggctgag
      121 gtgaagaagc ctggggcctc cgtgaaaatc tcctgccagg cttctggata caccttaacc
      181 gaccactacc tgcactgggt gcgacaggct cctggaaaag gacttgagtg gatgggaggt
      241 gttcatcctg aatatggtaa agcagactac acacagaagt tccaaaacag agtcaccatc
      301 accgcggaca tgtcgacaga gacagcctac atggagctga gcagcctcag atctgaggac
      361 acggccgttt attactgtgt gacagtgggt ccctaccatt actttgactt ctggggccag
      421 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004536             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20164:12501
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004536
VERSION     KCXD01004536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20164:12501"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..498
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63018.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       425..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          142 c          142 g          104 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtt cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatccacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttgc tcctctatat ggtgaaatga
      301 tgcacgcaga caacttccag ggcagagtca ccttgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg acgacacggc cgtgtattac tgtgcgcgtg
      421 ggcctattac aatttttggc gtacttatta cggggcttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004537             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21259:11390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004537
VERSION     KCXD01004537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21259:11390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..458
     V_segment       96..389
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63019.1"
                     /translation="CARDEDAYAYYYYFDHW"
     D_segment       391..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>464
                     /gene="IGHG"
BASE COUNT           90 a          136 c          140 g           98 t
ORIGIN      
        1 acatggggct gagagtcacg gacatcctgt gcaagaacat gaagcacctg tggttcttcc
       61 tcctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc
      121 caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct ggtggctcca
      181 tcagcagtaa ctactggagc tggatccgcc agcccccagg gaaggggctg gagtggattg
      241 gacgtatcca tggtagtggg gggagcaccg actacaaccc ctccctcaag agtcgagtca
      301 ccttttcaag agacaggtcc aagaaccagt tctccctgga gctgagctct gtgaccgcgg
      361 cggactcggc cgtgtattat tgtgcgagag acgaggatgc ttacgcttac tattactact
      421 ttgaccactg gggccaggga gtcctggtca ccgtctcccc agcc
//
LOCUS       KCXD01004538             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5024:13723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004538
VERSION     KCXD01004538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5024:13723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63020.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          143 c          143 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggaat tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004539             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11034:20158
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004539
VERSION     KCXD01004539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11034:20158"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63021.1"
                     /translation="CARYGDDSVHYNFDSW"
     D_segment       408..414
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          139 c          130 g          105 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtggct tctggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatatctatg gtggtactgg gagcaccggc tacaacccct ccctcaagaa
      301 tcgagtcacc atttcaacag acacgtcaaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tatattactg tgcgagatat ggagatgaca gtgttcatta
      421 caactttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004540             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14741:7412
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004540
VERSION     KCXD01004540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14741:7412"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63022.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          110 c          153 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004541             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:10628:12698
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004541
VERSION     KCXD01004541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:10628:12698"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63023.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggttca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcata
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004542             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12858:9865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004542
VERSION     KCXD01004542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12858:9865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63024.1"
                     /translation="CARDVRGTGFDFW"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          113 c          151 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttccgcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagct ttggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtatgatga
      301 aactaagaaa tactacgcag actctgtgag ggaccgattc accatctcca gagacaattc
      361 caaaaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg ccatatatta
      421 ctgtgcgaga gatgtcaggg gcacggggtt tgacttctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004543             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8945:21538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004543
VERSION     KCXD01004543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8945:21538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63025.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       430..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          118 c          144 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt acctctggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg gctgacagtt atatcgtatg atgagactaa
      301 gaaatactac gcagactctg tgaagggccg attcaccatc tccagagaca attccaaaaa
      361 catgctatat cttcaaatga acaacctgaa attggaggac gcggccgtgt attactgtgc
      421 gagagattct tacggtcgag gctttgactc ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01004544             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6142:6629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004544
VERSION     KCXD01004544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6142:6629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63026.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       425..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          144 c          133 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggcc cagctggtgc agtctggggc ggaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacatctt caccgaatta tcgttccact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatttg gtgaaatgat
      301 acacacagag aaattccagg gcagaatcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggaa ctaagcagcc tgagatctga ggacacggcc gtgtatttct gtgcgatatc
      421 atccagcggc agctggctat tctggtattt cgacatctgg ggccctggca ctccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004545             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23759:2561
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004545
VERSION     KCXD01004545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23759:2561"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    82..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        82..442
     V_segment       82..374
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <367..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63027.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       381..391
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           92 a          107 c          143 g          102 t
ORIGIN      
        1 acatggggaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
       61 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcgcag
      121 cctggggggt ccctgaaact cccctgcgca gcctctggat tcagcttcag ctacttctac
      181 atgagctggg tccgccaggc tccaggaaag gggctggagt ggatctcagg gattgacagt
      241 ggtgggggtg acacattcta tgcagactcc gtgaagggca gattcaccat ctccagagag
      301 aacgccaaga ggacactgta tcttcaaatg gacagcctga gacctgagga cacggctgtc
      361 tattactgtg cgaggtctac tgggagctac aggggatact ttgactactg gggccaggga
      421 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004546             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12636:15343
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004546
VERSION     KCXD01004546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12636:15343"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63028.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          119 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcccaga acacagagga ctcaccatga agtttgggct gagctaggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004547             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18863:8025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004547
VERSION     KCXD01004547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18863:8025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63029.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       412..422
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          107 a          144 c          132 g           92 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 agtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgagggtctc
      181 ctgcaggatt tccggataca ccttcaccga attatccata cactgggtgc ggcaggcccc
      241 tggaaaaggg cttgagtgta tgggaagtgt tgatcctctg tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacttgg aactgagcgg
      361 cctgacttct gaggacacgg ccgtgtatta ctgtgcgact ggccctaccg gcacctggaa
      421 cgcctggtac ctcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01004548             387 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14233:12082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004548
VERSION     KCXD01004548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 387)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 387)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14233:12082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..385
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..385
     V_segment       146..324
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <316..>354
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63030.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       328..339
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       344..385
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        386..>387
                     /gene="IGHG"
BASE COUNT           94 a           88 c          114 g           91 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca ttgtgaggct ccagggaagg gtctggagtg ggtggcagtt
      181 atgtcgcatg atggaactaa gaaattctac gcagactctg tgaaggaccg attcaccatc
      241 tccagggaca attccaagaa catggtatat cttcaaatga acaacctgag attggaggac
      301 gcggccgtct attattgtgc gagaggagac tacggtaaca gccttgactt ctggggccag
      361 ggagtcctgc tcaccgtctc ctcagcc
//
LOCUS       KCXD01004549             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20937:3337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004549
VERSION     KCXD01004549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20937:3337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..324
     V_segment       8..257
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63031.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       260..275
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..324
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        325..>326
                     /gene="IGHG"
BASE COUNT           64 a          101 c           92 g           69 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc agcagtacct
       61 actggagctg gatccgccag cccccaggga agggactgga gtggattgga cgtatctctg
      121 gtggtggtgg gaacaccgac tacaacccct ccctcaagag tcgagtcacc atttcaagag
      181 acacgtccag gaaccagttc tccctgcagc tgaattatgt aaccgccgcg gacacggccg
      241 tgtattactg tgccagaact agcggtggct ggtcccccta ctttgactat tggggccggg
      301 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004550             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17832:18180
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004550
VERSION     KCXD01004550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17832:18180"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63032.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          141 c          150 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat ggccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgacga cacggccgta tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004551             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18692:7081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004551
VERSION     KCXD01004551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18692:7081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..498
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63033.1"
                     /translation="CARARGVIITYFDHW"
     D_segment       442..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>504
                     /gene="IGHG"
BASE COUNT          105 a          126 c          156 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atggcctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggggatt ccacatacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 gacgccaaga acacactgta tcttcagatg gacagtctga attctgagga cacggctgtc
      421 tattactgtg cgagagcgcg cggggtgatt attacatact ttgaccactg gggccaggga
      481 gtcctggcca ccgtctcccc agcc
//
LOCUS       KCXD01004552             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:8388:15865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004552
VERSION     KCXD01004552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:8388:15865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63034.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          112 a          143 c          133 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaaatgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtg tattactgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01004553             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6448:12808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004553
VERSION     KCXD01004553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6448:12808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..464
     V_segment       109..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63035.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>470
                     /gene="IGHG"
BASE COUNT           95 a          131 c          131 g          113 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccgggtg cagctgcagg
      121 agtcgggccc aggactggtg aagtcttcgg agaccctgtc cctcacctgc gttgtctctg
      181 gtgactccat cagcaatagc tattggaact ggatccgcca gccccctggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaatccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgctgc ggacaccgcc gtgtattatt gtgtgagata tgaggatgaa tccattaact
      421 accactttga ctactggggc cagggagtcc tggtcaccgt ctccgcagcc
//
LOCUS       KCXD01004554             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10580:17178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004554
VERSION     KCXD01004554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10580:17178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..492
     V_segment       108..404
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <396..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63036.1"
                     /translation="CARRPLPYEDDYSYYLGIFDYW"
     D_segment       417..431
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          102 a          134 c          142 g          116 t
ORIGIN      
        1 acatgggggg gaaatgttct ctgagagtca cggacatcct gtgtaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcagctgc
      121 aggagtcggg cccagcagtg gtgaagcctt cagagaccct gtccctcacc tgcgctgtct
      181 ctggtggctc catcagcggt gattatggct ggaactggat ccgccaggcc ccagggaagg
      241 gactggagtt gattgggagt atttatggta gtagtggtaa cacctactac aacccctccc
      301 tcaagagtcg agtcaccatt tcaaaagaca cgtccaagaa ccagttctcc ctgaggctga
      361 gctctgtgac cgccgcggac acggccgtgt attattgtgc gagaagaccg cttccctacg
      421 aggatgatta cagttattat ttggggatct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004555             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23341:7836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004555
VERSION     KCXD01004555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23341:7836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63037.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       448..453
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          119 c          162 g          114 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtg
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggca
      181 aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaggcac
      241 tggatgaact gggtccgcca ggctccagga aaggggctag agtgggtctc aactattaat
      301 agtggtgggg ataacacata ttacgcagac tccgtgaagg gccgattcac catctccaga
      361 gacaactcaa agaacacgct cctcctgcaa atgaacagcc tgagagtgga ggacacggcc
      421 gtgtattact gtgttcaagg ggaaattttt ggagtgggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004556             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5280:16566
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004556
VERSION     KCXD01004556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5280:16566"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63038.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           91 a          138 c          131 g          107 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggcgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccgtcac cagtagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaggagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004557             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:4971:14859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004557
VERSION     KCXD01004557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:4971:14859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..445
     V_segment       137..366
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <358..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63039.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       383..396
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..445
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          100 a          107 c          128 g          112 t
ORIGIN      
        1 acatggggga gacaggagtc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgt agcctctgga ttcacctttg gtgattatgg catgcactgg
      181 gtccgccagg ctccgggaaa gggactggag tgggtctcat ccattagaaa cactggtaaa
      241 atcgtatact acgctgactc cgtgaagggc cgattcatca tctccagaga caacgccaag
      301 aattcgctgt ctctgcaaat gagcagcctg agagtcgagg actcggccgt ctattactgt
      361 actagaattg gcgtcggatc tctagcaccg gctggtgaat actttgacta ctggggccag
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004558             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:25631:13648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004558
VERSION     KCXD01004558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:25631:13648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63040.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          105 a          139 c          138 g           98 t
ORIGIN      
        1 acatgggggc atccaacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttga gtgggtggga agtgttgatc ctgcatatgg tgaaatggtg
      301 ttccagggca gagtcaccat gaccgaggat acgtctatag acacagccta catggagttg
      361 agcagcctga gatctgagga cacggccgtt tattactgcg cgattggccc tagcggcaac
      421 tggaacggct ggtccttcga tatctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01004559             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17509:10020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004559
VERSION     KCXD01004559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17509:10020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63041.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       434..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          113 a          113 c          151 g          119 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccggtgtg aggtgcaact ggtggagtct ggagggggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actttggcat
      241 acactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tttcatctga
      301 tggaagtaag aaatactacg caaactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atagtatatc ttcaaatgaa cagcctgaaa ttggaggaca cggccgtcta
      421 ttactgtgcg agagatgata tggggaccgg ttttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004560             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10883:16327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004560
VERSION     KCXD01004560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10883:16327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63042.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          139 c          127 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc cccccgggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 acctccgcgg actccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004561             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19720:8439
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004561
VERSION     KCXD01004561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19720:8439"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..474
     V_segment       121..414
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63043.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       418..433
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>477
                     /gene="IGHG"
BASE COUNT          101 a          147 c          124 g          105 t
ORIGIN      
        1 acatgggggt ctccctcacc gcacagctgg gatctcagtg cttcatttct gtcctccacc
       61 acgatggggt caactgccat cctcgccctc ctcctggctg ttctccaagg agtctgtgcc
      121 gaggtgcagc tggtgcagtc tggaacagag gtgaaaaggc ccggggagtc tctgaggatc
      181 tcctgtcaga cctctggata caactttccc agcagctgga tcacctgggt gcgccagatg
      241 cccgggaaag gcctggagtg gatggggacc atctatcctg ctgattctaa tgccaaatac
      301 aacccgtcct tccaaggcca cgtcactatc tcagtcgaca agtccatcag caccacctac
      361 ttgcagtgga gcaacctgaa ggcctcggac accgccacgt attactgtgc caaaacctac
      421 tatagtggta gtttggaata ctggggccag ggagtcctgg tcaccgtctc ctcaacc
//
LOCUS       KCXD01004562             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5368:10358
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004562
VERSION     KCXD01004562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5368:10358"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63044.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       447..455
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          115 c          152 g          128 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgttgctat
      121 gttaaaaggt gtccagtgtg tggagcagct ggtggaatct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctggattc accttcagta gctttgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctggactgg gtatcaggta ttaacattgg
      301 cggtgacaca tactacccag actctgtgaa gggtcgattc actatgtcca gagacaatgc
      361 caagaactcc gtgtatcttc aaatgaacag cctgagagtt gaggacactg ctgtgtattt
      421 ttgtgcaagg gggatagata actaccacta tagtgatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004563             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23525:12711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004563
VERSION     KCXD01004563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23525:12711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..496
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63045.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       418..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          114 a          140 c          145 g          101 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaaccctgg tgcctcagtg aagctctcct
      181 gcaagggttc tggattctcc ctcagcaccg aggccatcag ttgggtgcga caggcccctg
      241 gacaaggacc tgactggatg ggagggatca tccctctcgt gggtgcaaca aactacgcac
      301 agaagttcca gggcagagtc aagtttaccg cggacacgtc cataaacaca gcctacatgg
      361 aactgagcgg cctgagatct gaggacacgg ccgtgtatta ttgtgcgaaa tccgtgaatt
      421 acgaggaaga taacggttac tatttaccga cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01004564             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:7783:6678
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004564
VERSION     KCXD01004564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:7783:6678"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63046.1"
                     /translation="CARDSSWYNWNQDFDYW"
     D_segment       405..418
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT          100 a          137 c          132 g          100 t
ORIGIN      
        1 acatgggggt tctctgagac tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgacc cagctgcagc ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc aaatgcgctg tctctggtgg
      181 ctccatcacc ggtaactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt agcactgata gtggtgggag tactgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagatagt agttggtata actggaacca
      421 agactttgac tactggggcc agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004565             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19060:12437
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004565
VERSION     KCXD01004565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19060:12437"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63047.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       408..417
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          113 a          134 c          132 g          106 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg attcaccttc gacaactatg gtatcaactg ggtgcgacag gcccctggac
      241 aggggcttga gtggatggga gtaaccatcc cccttgttgg tataatcaac tacagagaca
      301 acgtccagga cagagtcacc atttccgcgg acacgtccac aaacacagcc tacatggaaa
      361 taaacagcct gagatctgac gacacggcca tctattactg tgcgagagaa tattgtactt
      421 ctactgattg cgccggattt tttgacttct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004566             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:20195:6662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004566
VERSION     KCXD01004566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:20195:6662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..491
     V_segment       134..426
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63048.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       432..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          112 c          146 g          118 t
ORIGIN      
        1 acatgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtaactatg gaatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt acgatgaaaa
      301 taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag acaattccaa
      361 gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg tttattactg
      421 tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac tcagggtcac
      481 cgtctcttca gcc
//
LOCUS       KCXD01004567             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18701:7330
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004567
VERSION     KCXD01004567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18701:7330"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..426
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63049.1"
                     /translation="CATGEYGNSIDFW"
     D_segment       435..442
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          110 a          113 c          150 g          118 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cggctggtgg agtctggagg aggcttggat cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcatctt cagtagcctt ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg tctgatggaa
      301 gtaagaagta ttatgcagac tctgtgaagg accgattcac catctccaga gacaatgcca
      361 agaacatgct ctttcttcaa atgaacaacc tgaaactgga ggacacggcc gtgtattact
      421 gtgcgacagg ggaatacggt aattctattg acttctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004568             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19578:5535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004568
VERSION     KCXD01004568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19578:5535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..457
     V_segment       100..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63050.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       399..408
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           80 a          142 c          134 g          103 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagtccc cagggatggg actggagtgg
      241 attggctttt tcggtggtta tggtgggaac acctactaca acccctccct ccagagtcga
      301 gtcaccattt caaccgacac gtccaagacc cagttctccc tgatactggc ctctgtgacc
      361 gccgcggaca cggccctcta ttactgtgcg agggggaata tagcagcgac tggcattgac
      421 tactggggcc agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004569             314 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6882:18351
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004569
VERSION     KCXD01004569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 314)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 314)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6882:18351"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..312
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..312
     V_segment       8..256
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>281
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63051.1"
                     /translation="CGSPLNWKASW"
     D_segment       263..271
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..312
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        313..>314
                     /gene="IGHG"
BASE COUNT           59 a           93 c           93 g           69 t
ORIGIN      
        1 acatggggga gaccctatct ctcagttgcg ctgtctctgg tggctccatc agcggttact
       61 ggtggggctg gatccgccag cccccaggga aggggctgga gtggattgga tttatcggtg
      121 gtagtagtgg gagcacctac tacaatccct ccctcaagag tcgagtcacc atttcagtag
      181 acacgtccaa gacccggttc tccctgaaac tgacctctgt gaccgccgcg gacacggccg
      241 tgtattactg tgggagcccc cttaactgga aagcatcttg gggccaggga gtcccggtca
      301 ccgtctcctc agcc
//
LOCUS       KCXD01004570             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22564:14771
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004570
VERSION     KCXD01004570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22564:14771"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63052.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          112 c          151 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg agggggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcatctgatg
      301 gaagtaagaa atactacgca aactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat agtatatctt caaatgaaca gcctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatg gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004571             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15061:17513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004571
VERSION     KCXD01004571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15061:17513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63053.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       449..454
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          120 t
ORIGIN      
        1 acatgggggc agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tgctatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt
      181 tcagccgggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
      241 tggcatccac tgggtccgcc aggctccagg gaaggggctg gagtgggtga cagttatatc
      301 gtatgatgaa acaaagaaat actacgcaga ctctctgaag gaccgcttca tcatctccag
      361 agacaattcc aagaacatgg tatatcttca aatgaataac ctgaaattgg atgacacggc
      421 cgtatattac tgtgtgagag atgtcagggg aacggggttt gacttctggg gccagggtgt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004572             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22643:15192
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004572
VERSION     KCXD01004572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22643:15192"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..494
     V_segment       146..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63054.1"
                     /translation="CARADRGSSIDYW"
     D_segment       445..451
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          114 a          115 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagaaga ctcaccatga agtttgggct gagttgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtggggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaacctatg
      241 gcatgcactg ggtccggcag gccccaggga aggggctgga gtgggtggcg gttatatcat
      301 atgatgatga caagaaatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttttattg tgcgagagcg gatcgcggca gttcaattga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01004573             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21238:12526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004573
VERSION     KCXD01004573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21238:12526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    92..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        92..473
     V_segment       92..385
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <377..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63055.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       390..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           98 a          131 c          137 g          109 t
ORIGIN      
        1 atgggggaga gtcacggaca tcctgtgcga gaacatgaag tatctgtggt tcttcctcct
       61 cctggtggca gctcccagat gggtcctgtc ccagctgcag ttgcaggagt cgggcccagg
      121 actgatgaag ccttcagaga ccctgtccct cagctgcgct gtctctggtg gctccataag
      181 tggtaactgg tggagctgga tccgccagcc cccagggaag ggactggact ggattggacg
      241 tatctctggt actagtgggg acaccaatta caatccctcc ctcaagagtc gagtcaccat
      301 ttcaacagac acgtccaaga accacttctc cctgaagctg aactctgtga ccgccgcgga
      361 cgcggccgtg tattattgtg caagagcgga ttacgaggat gattacggtt atcatttagg
      421 atacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004574             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13341:16172
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004574
VERSION     KCXD01004574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13341:16172"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..364
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <358..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63056.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       379..390
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       391..439
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           95 a          119 c          136 g           91 t
ORIGIN      
        1 acatggggga gagcacagca cctcaccatg gactggacct ggaggatcct cctcttggtg
       61 gcagcagcta caggcgccca ctctgaggtc cttctggtgc agtctggggc tgaggtgatg
      121 cagcctgggg cctcagtgaa ggtctcctgc aaggtttccg gaagaacctt caccgaatta
      181 tccatgcact gggtgcgaca ggcccctgga aaagggcttg agtgggtggg aagtgttgat
      241 cctgaatatg gtgaaatgat gttccagggc agagtcacca tgaccgagga cacgtctaca
      301 gacacagcct acatggagct gagcagcctg agatctgagg acacggccgt ctattactgt
      361 gcgattggcc ctagtggcag ctggaacgac tggtccttcg acatttgggg acctggcacc
      421 ccaatcaccg tctcctcagc c
//
LOCUS       KCXD01004575             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13882:19680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004575
VERSION     KCXD01004575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13882:19680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..446
     V_segment       83..382
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63057.1"
                     /translation="CARRIRGGWPYFDFW"
     D_segment       392..396
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           96 a          138 c          114 g          100 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tccacgctcc tgctgctgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcgc cgtctctggg ttctcactca acaatattgg
      181 tatgggggtg ggctggatcc gtcagccctc aggaaagacc ctggagtggc ttgcacacat
      241 ttactgggat gataacaagc tctacagcac atctctaaag aacagactca ccatctccag
      301 ggacacctcc aaaaacctgg tacttctgac aatgaccaac atggaccctg cggacacagc
      361 cacatatttc tgtgcacgaa gaattagggg cggttggccg tattttgact tctggggcca
      421 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004576             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9051:10077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004576
VERSION     KCXD01004576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9051:10077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..326
     V_segment       4..256
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63058.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       262..271
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..326
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           74 a           83 c           96 g           75 t
ORIGIN      
        1 acatgggggg tctctgagac tctcctgtgt agcctctgga ttcagcttca gaagttacga
       61 aatgagttgg gtccgccagg ctccgggaaa ggggctggag tgggtctcat atattagtca
      121 cactggtgaa accatatacc acgctgactc cgtgaagggc cgattcacca tctccagaga
      181 caacgccaag aattcgctgt ctctgcaaat gagcagcctg agagccgagg acacggccgt
      241 gtattactgt actaggaacc ggaatactgt aatgattggg tggttcgatg tctggggccc
      301 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004577             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16040:11220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004577
VERSION     KCXD01004577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16040:11220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63059.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       437..442
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          110 c          154 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgaa gtgcaactgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcag cttcagtggc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtttgatg
      301 aaactaagaa atattacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat gctgtatttt caattgaaca acctgaaatt ggaagacacg gccgtgtatt
      421 tctgtgcgag agatgtctat ggcaggggac ttgactactg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004578             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5841:8609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004578
VERSION     KCXD01004578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5841:8609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..446
     V_segment       101..387
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63060.1"
                     /translation="CASSDYGWFDVW"
     D_segment       392..400
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..446
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           92 a          122 c          127 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggaatc
      121 ggacccagga gtagtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 cgatagttat aggtggagct ggatccgcca gcccccaggg aagggactgg aatggattgg
      241 gtatatttat ggtagtatta cggacaccaa ctacaacccc tccctcaaaa gtcgagtcac
      301 catttcaaaa gacacgtcca agaagcagtt ctccttgaaa ctgagctctg tgaccgtcgc
      361 ggacacggcc gtgtatttct gtgcgagttc agactacggt tggttcgatg tctggggccc
      421 gggagtcttg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004579             416 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:26633:13585
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004579
VERSION     KCXD01004579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 416)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 416)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:26633:13585"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    36..414
                     /note="immunoglobulin heavy chain variable region"
     V_region        36..414
     V_segment       36..327
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <321..>383
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63061.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       341..354
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..414
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        415..>416
                     /gene="IGHG"
BASE COUNT           91 a          109 c          132 g           84 t
ORIGIN      
        1 acatgggggt ggcagcagct acaggcgccc actctgaggt ccacctggtg cagtctgggg
       61 ctgaggtgaa gcagcctggg gcctcagtga aggtctcctg taaggtttcc ggatacaccg
      121 tcaccgaatt atccatgcac tgggtgcgac aggcccctgg gaaagggctt gaatggatgg
      181 gagttgttga tcctgtcaat ggtgaagaaa tacacgcaga gaagttccag ggcagagtca
      241 ccatgaccga ggacacgtcg acagacacag cttacatgga cttgaccagt ctcagatctg
      301 aggacacggc catctattac tgtgcgacag ggaggatcgg tagcagcggc tggtccagcc
      361 tcttcaccgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004580             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18644:7906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004580
VERSION     KCXD01004580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18644:7906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63062.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       446..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          116 c          154 g          115 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcgg
      181 ccgggggggt ccctgagact ctcctgtgca gtctctggat tcaccttcaa tacctatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgggt
      301 gatgaaacta agaaatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattactgta cgagagacgc atttggcagc ggctgtgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004581             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19589:7656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004581
VERSION     KCXD01004581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19589:7656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63063.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       443..455
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          109 c          158 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gctgggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagcaacgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tgatatcgtt
      301 tgatgaaagt aagaaatact acgtagattc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 gtattactgt gtgagagact cttatggaag tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004582             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7861:9925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004582
VERSION     KCXD01004582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7861:9925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63064.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          119 c          155 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg tgaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgt caggctccag gaaaggggct ggagtggatc tcaagtattg acaatggtgg
      301 gactaccaca aattttgcag actccgtgag gggcaggttc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcgcgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004583             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16175:17658
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004583
VERSION     KCXD01004583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16175:17658"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63065.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       405..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           83 a          141 c          136 g          104 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtcgccaggg aaggggctgg
      241 agtggattgg gtttttcggt ggttatggtg ggaacaccta ctacaacccc tccctccaaa
      301 gtcgagtcac catttcaacc gacacgtcca agacccagtt ctccctgatt ctgacctctg
      361 tgaccgccgc ggacacggcc ctctatttct gtgcgagggg gaacatagca gcgactggca
      421 ttgactactg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004584             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:21027:10282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004584
VERSION     KCXD01004584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:21027:10282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63066.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       437..444
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          116 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 tcagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaactaagaa ataccacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg aatgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01004585             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11983:13775
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004585
VERSION     KCXD01004585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11983:13775"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..460
     V_segment       106..399
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63067.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       408..414
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT          106 a          106 c          136 g          114 t
ORIGIN      
        1 acatgggggt tccattcggt gatcagcaca gaacacagag gactcaccat gaagtttggg
       61 ctgagctggg ttttccttct tgctatttta agaggtgtcc agtgtgaggt gcagctggtg
      121 gagtctggag gaggcttggt tcagcctggg gagtccctga cactctcctg tgcagcctct
      181 ggattcacct tcagtaccta tggcatgcac tgggtccgcc aggctccagg gaaggggctg
      241 gagtgggtga cagttatatc gtatgatgaa agtaagaaat actacgcaga ctctctgaag
      301 ggccgattca ccatttccag agacaattcc aagaacacgc tatatcttca aatgaacaac
      361 ctgcaattgg aggacacggc cgtgtattac tgtgggagag atgataatgg ggtgcttatc
      421 gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004586             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17872:15783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004586
VERSION     KCXD01004586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17872:15783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63068.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          140 c          133 g           94 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01004587             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:6785:10721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004587
VERSION     KCXD01004587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:6785:10721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63069.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       437..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          137 c          150 g          109 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctgaaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gcgaggtgca gctggtggag tctgggggcg gcctggcaaa
      181 gcctggggga gccctgagcc tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtctcag ctattagtag
      301 tggtggcacc acatactacg cagcctccgt gaagggccga ttcaccgtct ccagagacaa
      361 ctcaaagaac acactctccc tacaaatgaa cagcctgaga actgaggaca cggccgtgtt
      421 ttactgtgcg aaagccgata cagctacacc atactacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004588             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:25404:8341
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004588
VERSION     KCXD01004588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:25404:8341"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63070.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          104 a          123 c          154 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggaatctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcatc cggattcacc ttcagtgacc actgcatgca
      241 ctgggtccgc caggcttcag ggaaggggct ggagtgggtc tcaggtatta cttatgctgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatatcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgtggga ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004589             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24251:14337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004589
VERSION     KCXD01004589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24251:14337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63071.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       450..458
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          115 c          149 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttattgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatgaaatt aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acactgccgt
      421 gtatttctgt gcgagggagg agagatttgg ctacagtttt gacttctggg gccagggaat
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004590             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12887:21296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004590
VERSION     KCXD01004590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12887:21296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63072.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          111 a          120 c          158 g          121 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactc ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctttgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagtc tgagagccga ggacacggcc
      421 gtgtattact gtactagaaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004591             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8032:12344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004591
VERSION     KCXD01004591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8032:12344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63073.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       445..457
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          110 c          159 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggctgggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcaac
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgatatcg
      301 tttgatgaaa gtaagaaata ctatgcagac tctgtgaagg accgattcac cgtctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaact tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga ctcttatgga agtggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004592             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15696:8000
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004592
VERSION     KCXD01004592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15696:8000"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..487
     V_segment       118..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63074.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       425..440
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          111 a          140 c          139 g           99 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgaa
      121 gtccagctgg tgcagtctgg ggctgaagtg aggaggcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggagacac cttcaccgaa ttatccgtgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtgggt gggaggtgtt catcctctat atggtaaaat aacacacgca
      301 gagaacttcc aggacagagt catcatgacc gaggacacgt cgacagacac agcctacatg
      361 gagctgagca gcctgacatc tgaggacacg gccgtctatt actgtgcgag aggattttgt
      421 catggtactt attgctcctc gggtcttgtc tcctggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01004593             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5524:8713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004593
VERSION     KCXD01004593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5524:8713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..466
     V_segment       88..380
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63075.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       386..393
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          125 c          148 g          100 t
ORIGIN      
        1 acatggggcc tgggaacaca gctcatcacc atggacttga cctggaggct cctctttgtg
       61 gtggcagcag ctacaggtgc ccagtcccag gtccagctgg tgcagtccgg ggctgaggtg
      121 aagaagcctg gggcctcagt gaagctctcc tgcaaggctt ctggatacac gttcggcatc
      181 tatgccatca gttgggtgcg acaggcccct ggacaagggc ttgagtggat gggagggatc
      241 atccctcttg ttgatataac aaactacgca cagaggttcc agggcagagt cacgatttcc
      301 gcggacacgt ccacaagcac agcctacatg gagctgagca gcctgagatc tgaggacacg
      361 gccgtgtatt actgtgcgag gggagattgt actgatactg actgctcttc cgcggggggc
      421 gcctttgatt tctggggcca agggctcagg gtcaccgtct cttcagcc
//
LOCUS       KCXD01004594             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:24250:3100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004594
VERSION     KCXD01004594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:24250:3100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..426
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63076.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       432..438
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          122 c          143 g          115 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgccatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtccggag gaggcttggt tcagccgggg
      181 gggtccctga gactctcctg tgcagcctct ggattcatct tcagtaccta tgccatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gaatgggtgg cagttatttc gcatgatgaa
      301 actactagat tctacacaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaacatac aatatcttca catgaacaac ctgaaattgg aggacacggc catatactac
      421 tgtgcggcct cctacttggg gtacggattt gagtactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01004595             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21044:14078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004595
VERSION     KCXD01004595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21044:14078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63077.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          117 c          153 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctttgg
      241 catgcactgg gtccgccagg ctccagggat ggggctggag tgggtggcag ttctatcttc
      301 cgatggaaat aagatatact acgcagactc tttgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgcgagatg tcaggggaac ggggtttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004596             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16496:13117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004596
VERSION     KCXD01004596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16496:13117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63078.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       413..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          106 a          149 c          133 g           94 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcccggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaacacct tcaccgaatt gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcccgcatat ggtgaaatga
      301 cattccaggg cagagtcttc atgaccgagg acacgtctac agacacagcc tacatggagc
      361 tgaccagcct gacatctgac gacgcggccg tctattactg tgcggttggc cctagcggca
      421 cttggaacca ctggtccttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01004597             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24981:11464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004597
VERSION     KCXD01004597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24981:11464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..415
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63079.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       425..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT           97 a          148 c          143 g          108 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctcctccac
       61 cacgatgggg tcaactgcca tcctcaccct cctactggct gttctccaag gagtctgtgc
      121 cgaggtgcag ctggtgcagt ctggagcaga ggtgaaaagg cccggggagt ctctgaagat
      181 ctcctgtaag acttctggag acacctctac ctactattgg atcagctggg tgcgccagat
      241 gcccgggaaa ggcctggagt ggatgggggc gattgatcct ggtaattctg ataccaaata
      301 tagtccgtcc ttccaaggcc atgtcaccat ctcagccgac aagtccatca gcaccgccta
      361 cctgcagtgg agcagcctga aggcctcgga caccgccacg tattactgcg cgaaaggggg
      421 gtggtggggt gattatccac cctcagactg gctcgatgtc tggggcccgg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004598             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:4899:15410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004598
VERSION     KCXD01004598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:4899:15410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..487
     V_segment       118..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63080.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       425..440
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          111 a          139 c          140 g           99 t
ORIGIN      
        1 acatggggac acaacaacac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgaa
      121 gtccagctgg tgcagtctgg ggctgaagtg aggaggcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggagacac cttcaccgaa ttatccgtgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtgggt gggaggtgtt catcctctat atggtaaaat aacacacgca
      301 gagaacttcc aggacagagt catcatgacc gaggacacgt cgacagacac agcctacatg
      361 gagctgagca gcctgacatc tgaggacacg gccgtctatt actgtgcgag aggattttgt
      421 catggtactt attgctcctc gggtcttgtc tcctggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01004599             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10442:11902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004599
VERSION     KCXD01004599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10442:11902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..506
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63081.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       433..439
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          114 a          112 c          158 g          124 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgctgctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcagc ttcagtggct ttggcataca
      241 ctgggtccgc caggctcctg ggaaggggct ggagtgggtg tcacttatat cgtatgatgg
      301 aagtaagaaa tactacgcag actctgtgaa ggaccgattc accttgtcca gagacaattc
      361 caagaacatg gtatatcttc acatgaacaa cctgaaattg gaggacacgg ccgtgtattt
      421 ctgtgcgaga gttagtgggc atacagaggg gacagttgaa aactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004600             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:4879:12710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004600
VERSION     KCXD01004600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:4879:12710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63082.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          134 c          128 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004601             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12959:2280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004601
VERSION     KCXD01004601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12959:2280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63083.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          121 a          142 c          141 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctgggacct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgta tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004602             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4994:14817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004602
VERSION     KCXD01004602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4994:14817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..448
     V_segment       85..378
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63084.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       387..402
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           87 a          136 c          129 g           98 t
ORIGIN      
        1 acatgggggg acctcctgtg caagaacatg aagcacctgt ggttcttcct tctcctggtg
       61 gctgctccca gatgggtcct gtcccagctg catctgcagg agtcgggccc aggactggtg
      121 aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtggctccat cagcaatagc
      181 tactggaact ggatccgcca gcccccaggg aaggggctgg agtggattgg gtctatctat
      241 ggtggtactg ggagcgccgg ctacaacccc tccctcaaga gtcgagtcac cgtttcaaca
      301 gacacgtcca agaaccagtt ttccctgaag ctgacgtctg cgaccgccgc ggacaccgcc
      361 gtgtattact gtgcgagata tgaggatgaa tacagtgact accactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004603             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:17493:21088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004603
VERSION     KCXD01004603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:17493:21088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63085.1"
                     /translation="CARGTGAILVYFDYW"
     D_segment       439..445
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          123 c          154 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtcctgtg tgagataaaa ctggtggagt ctgggggcga cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcctcag gcactactat
      241 ctgacctggg tccgccaggg tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtgggagta gcacatacta tgcagactcc gtgaaggaca gattcaccat ctccagagac
      361 aacgccaaga acacactgta tcttcaaatg gacaacctga gagctgagga cacggctgtc
      421 tattactgtg cgagggggac tggggcgatt cttgtgtact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004604             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20450:10744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004604
VERSION     KCXD01004604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20450:10744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..491
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63086.1"
                     /translation="CARYSDEDHYGDSLPQPPLYYFDFW"
     D_segment       402..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT           93 a          149 c          136 g          115 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggaggc cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtagctact ggaactggat ccgccagccc tcagggaagg ggctggagtg
      241 gattggatat atctatggta gtactgggag caccagttac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatattcc gacgaggatc attacggtga
      421 ctctttgccc cagccccccc tctattactt tgacttctgg ggccggggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004605             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7396:21584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004605
VERSION     KCXD01004605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7396:21584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63087.1"
                     /translation="CARRPWNADSFDYW"
     D_segment       445..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          112 a          124 c          149 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gccattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttgctt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc agttatatcg
      301 tttgatggaa ttaagaagta ccacgcagac tctgtgaagg accgattcac catctccaga
      361 gacgattccc agaacatgct ctatcttcaa atgaacaacc tgaaattgga agacacggcc
      421 gtgtattact gtgcgagacg cccttggaac gctgactcct ttgactactg gggtcaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004606             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19678:10585
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004606
VERSION     KCXD01004606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19678:10585"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63088.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       437..449
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          117 c          151 g          116 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggttcgccc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gctttggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggaatgg gtggcagttt tgtcgtctga
      301 tggaagttac aaataccacg cagactctaa gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atcctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttactgtgcg agaggggaat acagtaactc tattgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004607             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11374:11997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004607
VERSION     KCXD01004607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11374:11997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63089.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       443..448
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          104 a          125 c          157 g          114 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cacaccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccat tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctaaga ctctcctgtg cagcatccgg attcagcttc agtgaccact
      241 gcatgcactg ggtccgccag gcttcaggga aggggctgga gtgggtctca ggtattactt
      301 atactggtgt taccacatgg tacgcagact ccgtgagggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagacctgag gacacggctg
      421 tctattactg tgtgggagga aggcggcacg tggaccttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004608             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22229:10121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004608
VERSION     KCXD01004608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22229:10121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63090.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       399..407
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          136 c          139 g          105 t
ORIGIN      
        1 acatggggat gttctctaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctctggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatgag cagtcactac tgcagctgga tccgccagtc cccagggagg ggactggagt
      241 ggattggacg gatctctggt agtggtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ctcaacagac acgtccaaga aggagatctc cctgaagctg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagagaaga ctatggtggt aattattatt
      421 ttaaccggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004609             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16721:18416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004609
VERSION     KCXD01004609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16721:18416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63091.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       401..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           83 a          139 c          137 g          102 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcagaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc cccagggaag gggctggagt
      241 ggattgggtt tttcggtggt agtggtggga gcacctacta caaatcctcc ctccagagtc
      301 gcgtcaccat ttcaaccgac acgtccaaga accagttctc cctaatactg acctctgtga
      361 ccgccgcgga cacggccctc tattactgtg cgagggggaa tatagcagcg actggcattg
      421 actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004610             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17717:12056
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004610
VERSION     KCXD01004610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17717:12056"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63092.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       444..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          114 c          154 g          124 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctcgggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttttggca
      241 tgcactgggt ccgccaggct ccagggaggg ggctggagtg ggtggcagtt atgtcgtctg
      301 atggaagtaa catatactac gcagcctctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgttatat cttcaaatga acaacctgca atttgaggac acggccgtgt
      421 attactgtgc gagagatgtg tacggtagtg ggttagacta ctggggcctg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004611             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8097:9349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004611
VERSION     KCXD01004611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8097:9349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..378
     V_segment       24..317
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63093.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       330..336
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       337..378
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           91 a           87 c          116 g           86 t
ORIGIN      
        1 acatgggaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
       61 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      121 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      181 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      241 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      301 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc ccgggagtcc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004612             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10708:9413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004612
VERSION     KCXD01004612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10708:9413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63094.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          112 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgatc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004613             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13960:18471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004613
VERSION     KCXD01004613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13960:18471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63095.1"
                     /translation="CARERCTSSVCAGFLDYW"
     D_segment       420..424
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          143 c          139 g          100 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccacctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg cggggcttct ggattcacct tcgacaccca tggtatcaac tgggttcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat accccttatt ggtatcacaa
      301 actacgcaaa gaactctcag ggcagagtca caataagcgc gaacacgtcc acaaacacag
      361 cctacatgga gctgaacagc ctgagatctg aggacacggc catctactac tgtgcgagag
      421 aacgctgcac ttctagtgtt tgcgccgggt tccttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004614             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13448:13257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004614
VERSION     KCXD01004614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13448:13257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63096.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          113 c          150 g          133 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgt tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagttggtgg aatctggggg aggattggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagcttt
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactttagta atacggagtt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004615             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15191:15249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004615
VERSION     KCXD01004615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15191:15249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..507
     V_segment       117..410
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <402..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63097.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       429..451
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          104 a          144 c          143 g          118 t
ORIGIN      
        1 acatggggag ctcacatggg aaatgctctc tgagagtcac ggacatcctg tgcaagaaca
       61 tgaagcacct gtggttcttc ctcctgctgg tggcagctcc cagatgggtc ctgtcccagg
      121 tgcagctgca ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcacct
      181 gtgatgtctc tggtgcctcc atcagtactt cctggtggac ctggatccgc cagcccccag
      241 ggaagggact ggagtggatt ggggagatca atggttatag tggtagtttt tactccaacc
      301 cctccctcaa cagtcgagtc accatttcaa aagacgcgtc caagaaccag ttcgccctga
      361 aactgagctc tgtgaccgcc gcggacacgg ccgtatatta ctgtgcgcga gatgccgggt
      421 ttggggaaac gatattagta gtcgatatta atatgttccc ccactttgac tcctggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004616             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6600:15905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004616
VERSION     KCXD01004616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6600:15905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..478
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63098.1"
                     /translation="CARYGADSEDDYDYYSFDYW"
     D_segment       411..432
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           95 a          134 c          139 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacttgcgc tgtctctggt
      181 gactccatca ccagtagctt ctggagttgg atccgccagc ccccagggaa ggggctggag
      241 tggattggga atatctatgg gagtactggg agcaccggct acagcccctc cctcaagagt
      301 cgagtctcca tttcaacaga cacgtccaag aaccagtttt ccctgaaagt gagctctgtg
      361 accgtcgcag acaccgccgt gtattactgt gcgagatatg gggcggattc cgaggatgat
      421 tacgattact atagttttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004617             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17869:12228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004617
VERSION     KCXD01004617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17869:12228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63099.1"
                     /translation="CATGPTSTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          109 a          145 c          133 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcag gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctgtatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac ttggaactga
      361 gcggcctgac ttctgaggac acggccgtgt attactgtgc gactggccct accagcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004618             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21406:16486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004618
VERSION     KCXD01004618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21406:16486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63100.1"
                     /translation="CASGRTHWMELAALMGGLDSW"
     D_segment       415..420
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>502
                     /gene="IGHG"
BASE COUNT          111 a          136 c          152 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga gatgaagaag cctggggcct ctgtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgagttttcc atgcactggg tgcgactggc
      241 ccctggaaaa ggacttgagt ggatgggagg tgttgatcct ctatctggtg acatagtaca
      301 cgcagaaaag ttccagggca gagtcaccat gaccgaggac acgtctgcag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtc tattactgtg cgagtgggag
      421 gacacattgg atggagttgg cggccttaat gggcggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtcttgtcag cc
//
LOCUS       KCXD01004619             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18893:18811
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004619
VERSION     KCXD01004619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18893:18811"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..434
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63101.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       441..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          110 a          120 c          157 g          120 t
ORIGIN      
        1 acatggggtc tgagagagga gccttagccc tggatttcaa ggcactccca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggagg cttggtccag
      181 cctggagggt ctctgagact ctcctgtgta gcctctggat tcagcttcag aagttacgaa
      241 atgagttggg tccgccaggc tccgggaaag gggctggagt gggtctcata tattagtcac
      301 actggtgaaa ccatatacca cgctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga attcgctgtc tctgcaaatg agcagtctga gagccgagga cacggccgtg
      421 tattactgta ctagaaaccg gaatactgta atgattgggt ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004620             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15484:4813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004620
VERSION     KCXD01004620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15484:4813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63102.1"
                     /translation="CARSQSYCGGLYCFGYYYFDYW"
     D_segment       423..431
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           94 a          144 c          133 g          119 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtgc agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg
      181 tggctctttc agcagtacta aatggtggag ttggatccgc cagcccccag ggaaagggct
      241 ggagtggatt gggtatatca gtggtagtag tggtaacacc ttctacaacc cctccctcaa
      301 gagtcgagtc accatttcaa cggacacgtc caacaaccag ttctccctga agctgacctc
      361 tgtgaccgcc gcggacacgg ccgtttatta ttgtgcgaga tcccaatcct attgtggtgg
      421 cctttactgc ttcggctact actactttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01004621             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7594:13539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004621
VERSION     KCXD01004621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7594:13539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63103.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       435..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          104 a          115 c          156 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcatctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttc ctttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggactggg tggcagttat gtcgtctgat
      301 ggaagtaaca agtactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tggtttatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga gagatgtctt tggcgggggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004622             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12046:16821
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004622
VERSION     KCXD01004622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12046:16821"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63104.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          120 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagt cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gagactggag gacgcggccg
      421 tctattactg tgcgagagga gactacggta acagccttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01004623             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24793:9521
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004623
VERSION     KCXD01004623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24793:9521"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63105.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       439..445
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          114 c          147 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttc ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggcgtccctg agactctcct gtgcagcctc tggattcacc ttcagtagtt atggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg acagttatat cgtatgatga
      301 aagtaagaaa tactacgcag actctctgaa ggaccgattc accatttcca gagacaattc
      361 caagaacacg ctatatcttc aaatgaacaa cctgcaattg gaggacacgg ccgtgtatta
      421 ctgtgcgaga gatgataatg gggtgcttat cgacttctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004624             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10347:14538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004624
VERSION     KCXD01004624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10347:14538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63106.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       437..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          127 c          153 g          115 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcagta cctattctgt
      241 acactgggtc cgccaggctc cagggaaggg gctggagtgg gtctcaggta ttagtactgc
      301 tgggaccaca tattacacag actccgtgaa gggccgattc accatctcca gagacaactc
      361 aaagaacacg ctctccctgc aaatgaacag cctgagagct gaggacacgg ccctgtatta
      421 ctgtgcgaaa ggggagacag cttcagttta ttacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004625             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16682:11706
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004625
VERSION     KCXD01004625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16682:11706"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63107.1"
                     /translation="CVRDSSWYNWDQDFDYW"
     D_segment       407..417
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           99 a          131 c          138 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgaaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtcac tcaaatgcgc tgtctctggt
      181 ggctccatca ccgggaacta ctggagttgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtaccactga tagtggtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcagcaga cacgtccaag aaccagttct ccctggagtt gaggtctgtg
      361 accgccgcgg acacggccgt gtattattgt gtgagagata gtagttggta taactgggac
      421 caagactttg actattgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004626             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:4496:5853
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004626
VERSION     KCXD01004626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:4496:5853"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63108.1"
                     /translation="CATADYGNSLDFW"
     D_segment       435..446
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          115 c          148 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaattgg tggagactgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcatctgatg
      301 gaattatgag ctactactca gacgctatga aggaccgatt taccatctcc agagacaatt
      361 ccaagaacat gctatatctt caagtgaaca acctgaagtt ggaggacact gccgtttatt
      421 actgtgcgac agccgactac ggtaacagcc ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004627             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17489:3168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004627
VERSION     KCXD01004627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17489:3168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..457
     V_segment       105..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63109.1"
                     /translation="CAGGKRQLDLDYW"
     D_segment       407..413
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           90 a          133 c          129 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 tttttcctcc tcctggtggc agctcccaga tgggtcctgt cccggctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt
      181 gactctatta gcacttactt ctggaactgg atccgccagg ccccagggat gcgactggag
      241 tggattggat ttatctatgg ttatgatagt agcaccaact acaacccctc cctcaagagt
      301 cgagtcagcc tgtcagttga cacgtccaac aaccagctct ccctaaagct gacctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgggcggga agaggcaact ggatcttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004628             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:24054:20705
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004628
VERSION     KCXD01004628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:24054:20705"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..469
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63110.1"
                     /translation="CMRYEDESINYHFDFW"
     D_segment       403..410
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           96 a          137 c          130 g          108 t
ORIGIN      
        1 acatggggga atgctgctct gagagtcatg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc ttctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct
      181 ggtgactcca tcagcagtag ctactggaac tggatccgcc agcccccagg gaagggactg
      241 gagtggattg ggtatatctc tggcgcttat gggagcacca gctacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccagt tttccctgag gctgagttct
      361 gtgaccgccg cggacaccgc cgtgtattat tgtatgagat atgaggatga atccattaac
      421 taccactttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004629             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22911:12844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004629
VERSION     KCXD01004629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22911:12844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63111.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       443..448
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          120 c          151 g          118 t
ORIGIN      
        1 acatggggga gctctgggac aggagcccag ccctggaaga ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgaactgggt ttttcttgtt
      121 gctattttaa gaggtgtccc gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcccctt cagtcactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtcatatca
      301 tacgacgaaa gtaagaaata ctacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt ttatcttcag atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgcgaggag gccctggagt gcagatgctt ttgatttctg gggccaagga
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01004630             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:19715:6288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004630
VERSION     KCXD01004630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:19715:6288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..493
     V_segment       133..426
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63112.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       435..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          102 a          120 c          156 g          117 t
ORIGIN      
        1 acatgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg atcagcacta
       61 aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc tcttttgaaa
      121 ggtgtccagt gtgaggtgca gctggtggag tctgggggcg acttggcaaa gcctgggggg
      181 tccctgagac tctcctgcgc tgcctctgga ttcagcttca gttactacta catgagctgg
      241 gtccgccagg ctccagggaa ggggctggag tggatctcgg gtattgacag tggtgggggt
      301 accacatact atgcagactc cgtgaagggc agattcacca tctccagaga gaacgccgag
      361 aacacactgt atcttcaaat ggacagcctg acagctgagg acacggctgt ctattactgt
      421 gcgagagtcg tgggtggtag tgctggatac tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004631             281 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6716:20993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004631
VERSION     KCXD01004631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 281)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 281)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6716:20993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..279
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..279
     V_segment       8..214
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <207..>248
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63113.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       220..225
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       231..279
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        280..>281
                     /gene="IGHG"
BASE COUNT           76 a           64 c           77 g           64 t
ORIGIN      
        1 acatgggcag taactatgga atgcactggg tccgccaggc tccagggaag gggctggagt
       61 gggtggcagt tatatcgtac gatgaaaata agaaatacta cgcagactct ctgaaggacc
      121 gattcaccat ctccagagac aattccaaga acatgcttta tcttcaaatg aacaacctga
      181 aattggagga cacggccgtt tattactgtg cgaggaggcc ctggagtgca gatgcttttg
      241 atttctgggg ccaaggactc agggtcaccg tctcttcagc c
//
LOCUS       KCXD01004632             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:24469:19322
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004632
VERSION     KCXD01004632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:24469:19322"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63114.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          122 c          148 g          118 t
ORIGIN      
        1 acatggggac tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaaat aacctatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtgt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatt catatggcag cggctccgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004633             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:6805:11338
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004633
VERSION     KCXD01004633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:6805:11338"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63115.1"
                     /translation="CAATGEPLEYFDFW"
     D_segment       406..410
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..464
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          133 c          138 g          103 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggagtggtga ggccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 aggatctatc agcagtggtt atgactggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtatatct atggtactag tgggagcacc aactacaatg cgtccctcaa
      301 gaatcgagtc accatttcaa aagacgcgtc caagaaccag ttctccctgc agttgaggtc
      361 tgtgaccgcc gcggacacgg ccgtttatta ctgtgcggcg acaggggaac cccttgaata
      421 cttcgacttc tggggccagg gcgccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004634             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17459:17862
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004634
VERSION     KCXD01004634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17459:17862"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..492
     V_segment       141..433
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63116.1"
                     /translation="FSRDRQKEIDFR"
     D_segment       434..438
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          128 c          146 g          110 t
ORIGIN      
        1 acatggggct gcagctctga gagaggagcc ttagccctgg atttcaaggc acttccacct
       61 ggggatcagc actgaacaca gaggacccac catggagttg gggctgagct gggttttcct
      121 tgttgctatt ttaaaagtgt gaggtgcaac tggtggagtc tgggggagac ttggtccagc
      181 ctggagggtc cctgagactc tcctgtgcag cctctggatt caccttcagt cgttccgaca
      241 tgacctgggt ccgccaggct ccgggaaagg ggctggagtg ggtctcatat attacttaca
      301 cggaaaaaac cataaactac gctgactccg tgaagggccg attcaccatc tccagagaca
      361 acgccaagaa gtcgctgtct ctgcaaatga gcagcctcag agccgaggac gcggccgtgt
      421 gtttctttag tagagatcgt caaaaagaga ttgacttccg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004635             387 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16530:12977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004635
VERSION     KCXD01004635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 387)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 387)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16530:12977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    31..385
                     /note="immunoglobulin heavy chain variable region"
     V_region        31..385
     V_segment       31..323
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <316..>354
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63117.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       330..341
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       342..385
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        386..>387
                     /gene="IGHG"
BASE COUNT           78 a          116 c          110 g           83 t
ORIGIN      
        1 acatgggcag ctcccaaatg ggtcctgtcc cagctacaat tgcaggagtc gggcccagga
       61 ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg ctctatcagc
      121 atttactact ggaattggat ccgccaggcc ccagggaagg gactggactg gattggacat
      181 atctatggta gcggtgatag caccaacttc aacccctccc tcaagagtcg agtcaccctg
      241 tcagtagaca cgtccaagaa ccagttctcc ctgaacctga ggtctgtgac cgccgcggac
      301 acggccgtat attactgtgc gagcggtcgg cggcagctgg actttgacta ctggggccag
      361 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004636             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12254:12996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004636
VERSION     KCXD01004636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12254:12996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63118.1"
                     /translation="CVTVGSYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          143 c          130 g           94 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttcc ggatacacct taaccgacca ctacctacac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtattct tcctgagtat ggtaaagttg
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggttccta ccattacttt gactactggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01004637             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5603:11170
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004637
VERSION     KCXD01004637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5603:11170"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63119.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          112 c          147 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc aatcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca attggtggag tctggaggag gcttggttca
      181 gcctgggggg accctgaggc tctcctgtgc agcctctgga ttcaccttca gtaattatgg
      241 cttgcactgg gtccgccagg ctccagtgaa ggggctggag tgggttgcag ttatatcgta
      301 tgatgaaaat gtgaaattct acgcagactc tgtaaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagggg aatacagtaa ctctattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004638             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17711:7560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004638
VERSION     KCXD01004638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17711:7560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63120.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       262..273
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           75 a           83 c           92 g           71 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cactaactat
       61 ggcatgcact gggtccgcca ggctccaggg aagggtctgg agtgggtggc agttatgtcg
      121 catgatggga ctaagaaatt ctacgcagac tctgtgaagg accgattcac catctccagg
      181 gacaattcca agaacatggt atatcttcaa atgaacaacc tgagattgga ggacgcggcc
      241 gtctattact gtgcgagagg agactacggt aacagccttg actactgggg ccagggagtc
      301 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01004639             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11561:19137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004639
VERSION     KCXD01004639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11561:19137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63121.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          127 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaggc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgtcagccc ccagggaagg gactggagtg
      241 gattggttat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga cttctgtgac
      361 cgccgcggac accgccatgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004640             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:2984:8789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004640
VERSION     KCXD01004640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:2984:8789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..430
     V_segment       79..368
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63122.1"
                     /translation="CASNSITSGPDYW"
     D_segment       374..380
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..430
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT           81 a          134 c          122 g           95 t
ORIGIN      
        1 acatgggggt gcaagaacat gaggcacctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccgcct gcagctgcag gcggcgggcc caggactggt gaagccttcg
      121 gagaccctgt ctctcacctg cgctgtctct ggtggctcta tcagcggtaa ctactggagc
      181 tggatccgcc gggccccagg gaagggactg gagtggattg gatatatcta cggtagtgat
      241 tttaccacca actacaaccc ctccctcaag agtcgagtca ccctgtcagc agatacgtcc
      301 aagaaccagc tctccctgaa cctggcctct gtgaccgccg cggacacggc cgtctatttc
      361 tgtgccagta atagtataac atctggtcca gattactggg gccggggagt cctggtcacc
      421 gtctcctcag cc
//
LOCUS       KCXD01004641             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14461:17252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004641
VERSION     KCXD01004641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14461:17252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63123.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          102 a          123 c          161 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tcggggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaatag
      301 tggtggggat gatacatact atgcagactc cgtgaagggc cgattcacct tgtccagaga
      361 gaacgccaag aacacactgt atcttcacat ggtcagcctg agaggtgagg acacggctgt
      421 ctattactgt gcgagagacc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004642             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7973:11148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004642
VERSION     KCXD01004642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7973:11148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    97..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        97..457
     V_segment       97..390
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63124.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       410..416
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           82 a          137 c          142 g           98 t
ORIGIN      
        1 acatggggtc tgagagtcac ggacatcctg tgcaagaaca tgaagcacct gtggttcttc
       61 ctcctcctgg tggcagctcc cagatgggtc ctgtcccagc tgaagctgca ggagtcgggc
      121 ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc tggtgtctcc
      181 atcagcactc actcctggag ctgggtccgc cagcccccag ggaagggact ggagtggatt
      241 ggacgtatct ctggtagtgg tgggcgcacg gactacaatc cctccctcaa gagtcgagtc
      301 accttttcaa cagacacgtc caggaaccag ttgtccctga ggctgacgtc tgtgaccgcc
      361 gcggacacgg ccgtgtatta ctgtgcgaga gttgaaagcg cctggtccgt ggggtgggat
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004643             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18275:20804
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004643
VERSION     KCXD01004643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18275:20804"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..498
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63125.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>504
                     /gene="IGHG"
BASE COUNT          117 a          145 c          145 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgatttat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga gttgttaatc ctgtaaatgg agaaatgata
      301 cacgcagaga agttccaggc cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tggtcagcct gacatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcgtctg gtccagcctc ttcaacggct tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctccgc agcc
//
LOCUS       KCXD01004644             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11950:14131
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004644
VERSION     KCXD01004644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11950:14131"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63126.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          135 c          127 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 atccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtt cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cttccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004645             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14155:18378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004645
VERSION     KCXD01004645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14155:18378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63127.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          134 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatccact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg gggcctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004646             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15309:19839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004646
VERSION     KCXD01004646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15309:19839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..494
     V_segment       141..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63128.1"
                     /translation="CATADYGNSLDFW"
     D_segment       438..449
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>497
                     /gene="IGHG"
BASE COUNT          111 a          119 c          148 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcga
      121 ttttaagagg agtccagtgt gaggtgcagc tggttgagtc tgggggaggc ttaattcagc
      181 cgggggggtc ccggagactc tcctgtgcag cctctggatt caccttcagt agctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcagtt atatcgtctg
      301 atggaagtat gagattctac gcagactcta tgaaggaccg attctccatc tccagagaca
      361 attccaagaa catggtatat cttcaactga acaacctgaa attggaggac actgccgttt
      421 attactgtgc gacagccgac tacggtaaca gccttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcaacc
//
LOCUS       KCXD01004647             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20177:11649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004647
VERSION     KCXD01004647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20177:11649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63129.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          141 c          129 g           92 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctt
      181 ctgccaagct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatggtaaag tagactacac
      301 acagaagttc cgagacagag tcaccatcac cgcggacatg tcgacagaga cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgacttct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01004648             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7735:1991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004648
VERSION     KCXD01004648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7735:1991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..462
     V_segment       84..375
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63130.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       398..404
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..462
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT          106 a          124 c          141 g           93 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaggtcc aactggtgca gtctggggct gaaatgaaga
      121 agcctggggc ctcagttagg gtctcctgca aggtttccgg aaacaccttc accgaattat
      181 ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtggatggga tgtgtcgatc
      241 ctgcacaagg tgaaataata cacgcagaga aattccaggg cagagtcacc atgaccgagg
      301 acacgtccac agacacagcc ttcatggagt tgagcagcct gagatctgag gacacggccg
      361 tgtatttctg tgcgaaaggg gggttcggaa ccagcgtctg gtccaacctc ttctacggct
      421 tggattcttg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004649             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14461:11785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004649
VERSION     KCXD01004649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14461:11785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63131.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       431..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          124 c          158 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagcacc tatgctatgc
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagtacata ctacgcagac tccgtggggg gccgattcac catctccaga gacaactcag
      361 agaacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc gtatattact
      421 gtgcgaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004650             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12141:6343
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004650
VERSION     KCXD01004650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12141:6343"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63132.1"
                     /translation="CAIGPTGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          110 a          143 c          135 g           93 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gacacacctt caccgaattg tccattcact gggtgcgaag
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgaatatg gtgaaatgaa
      301 gttccaggcc agagtcacca tgaccgagga cacgtccaca gacacagcct acatggaact
      361 aaacagcctg agatctgagg acacggccgt gtattactgt gcgattggcc ctaccggcag
      421 gtggaacgac tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01004651             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:10997:13614
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004651
VERSION     KCXD01004651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:10997:13614"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63133.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       450..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          115 c          155 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgagataca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtt
      301 tgatggaagt aagaaatact acgcagactc tatgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctag atcttcaaat gagcaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagaatgg attgtactgg tggtgtctgc tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004652             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13429:13633
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004652
VERSION     KCXD01004652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13429:13633"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63134.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       418..437
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          141 c          145 g          107 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata caccttgagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtct attattgtgc gagaggctac
      421 tgtactggta gtggttgtaa ccttacattc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01004653             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21401:4859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004653
VERSION     KCXD01004653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21401:4859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63135.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          111 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatcttaag agctgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg tagcttctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaga tgaacaacct gaaattgaag gacacggccg
      421 tatactattg tgggagagat gataatgggg tgattatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004654             290 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:24629:5197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004654
VERSION     KCXD01004654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 290)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 290)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:24629:5197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..288
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..288
     V_segment       8..221
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <213..>257
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63136.1"
                     /translation="CARGHGLWSSPFDSW"
     D_segment       231..237
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..288
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        289..>290
                     /gene="IGHG"
BASE COUNT           69 a           75 c           88 g           58 t
ORIGIN      
        1 acatgggcat cgtcaccgaa ttaaccatgc actgggtgcg acaggcccct ggaaaagggc
       61 ttgagtggat gggaggtgtt gatcccagaa atggtgaaga aatgtacgga gacaagttcc
      121 agggcagagt caccatgacc gaggacacgt ctacagacac agcctatttg gagctgacca
      181 gcctgagatc tgaggacacg gccgtctatt actgtgcgag aggacatggc ctatggtcgt
      241 ccccttttga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004655             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20453:11815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004655
VERSION     KCXD01004655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20453:11815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63137.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          117 a          114 c          161 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcccggggg gtcactgaga ctgtcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggaggca cttatatcta
      301 atgatggaag taagaaatat tacgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctg tatcttcaaa tgaacaacct gaaattggat gacacggccg
      421 tgtattactg tgcgcgagtt ggagagggta gtggtggtgc ggaggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004656             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13607:8856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004656
VERSION     KCXD01004656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13607:8856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63138.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       421..428
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          136 c          152 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgaccctgga aatggtgaaa taatacacgc
      301 agatagtttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gaggggggtt
      421 cggtagcagt gtctggtcca atctcgttta tggtttggat tcctggggcc aaggggtcgc
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004657             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15715:22596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004657
VERSION     KCXD01004657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15715:22596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63139.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          115 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggac gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004658             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13405:6175
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004658
VERSION     KCXD01004658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13405:6175"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..429
     V_segment       75..368
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63140.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       381..387
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       388..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT          100 a           97 c          127 g          107 t
ORIGIN      
        1 acatgggagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctgttttaa
       61 gaggtgtcca gtgtgaggtc cagctggtgg agtctggagg agacttggtt cagcctgggg
      121 ggtccctcag actctcctgt gcagcctctg gattcacctt cagtaactat ggcatacact
      181 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg tctgatggaa
      241 gtaagacata ctacgcaaac tctgtgaagg accgattcac catattaaga gacaattcca
      301 agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc ctctattact
      361 gtgcgagaga cgatatggga agtggctttg actactgggg ccagggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01004659             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18514:4577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004659
VERSION     KCXD01004659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18514:4577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63141.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       428..435
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          106 a          141 c          145 g           99 t
ORIGIN      
        1 acatgggggc atcacataac aaccacctcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacctgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgatgtgaa gaagcctggg gcctcagtga
      181 aactctcctg caaggcttct ggattcgcct tcagaatgta tgccctcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagggatcgt cccgcttgtt ggaacaacaa
      301 actccgcaca gaagttccag ggcagagtca cgattaccgc ggacacgtcc ataagcacag
      361 tctacatgga actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgagag
      421 gcctgggtag cagcgcccac tttggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004660             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:21111:15530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004660
VERSION     KCXD01004660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:21111:15530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63142.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          144 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccat
      121 tctgaggtcc agctggtgca atctggggct gaggtgatgc agcctgggac ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctttatatgg tgaaatgata
      301 cacacagaac agttccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagtggc
      421 cctagcggca gctggaacga ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004661             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21191:6359
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004661
VERSION     KCXD01004661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21191:6359"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63143.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          117 c          160 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacgtttgg
      241 cgtccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatggaagt aaaaagtacc acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccgag gccaagctat atcttcaaat gaacaagctg aaagtggagg acgcggccgt
      421 gtactactgt gtgagagacg cgtatggttc cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004662             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8020:2604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004662
VERSION     KCXD01004662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8020:2604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63144.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       395..403
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          133 c          130 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgttcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccaaatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcaga agtaactact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gataggttat gtctatggtg atagtgggaa caccgaatac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagact cgtccaagaa tcagttttcc ctgaagctga gttctgtgac
      361 cgccgcggac accgccgtgt atcactgtgc gagatacagt tacggttcca actacttctt
      421 tgggttcttt gactattggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004663             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19393:15864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004663
VERSION     KCXD01004663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19393:15864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63145.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       412..420
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT          108 a           96 c          145 g          115 t
ORIGIN      
        1 acatggggga gagatcgagt gggagtggac atgagtaaga gaaacagtgg atatgtgtgg
       61 cagtttctga ccttggtgtc tctctgtttg caggtgtcca gtgtgaggtg cagctggtgg
      121 agtctggagg agacttggtt cagcctgggg ggtccctgag actctcctgt gcagcctctg
      181 gattcacctt cagtacctat ggcatgcact gggtccgcca ggctccaggg aaggggctgg
      241 agtgggtggc agttatatcg tctgatgaaa ttaagaaata ctacgcagac tctctgaagg
      301 accgattcac catatccaga gacaattcca agaacatggt ttatcttcaa atgaacaacc
      361 tgaaattgga ggacacggcc gtgtattact gtgcgaggga ggagaaattt ggctacagtt
      421 ttgacttctg gggccaggga atcctggtca gcgtctcctc agcc
//
LOCUS       KCXD01004664             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18409:14373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004664
VERSION     KCXD01004664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18409:14373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..465
     V_segment       109..402
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63146.1"
                     /translation="CARVRGGIAGYFDYW"
     D_segment       411..421
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>471
                     /gene="IGHG"
BASE COUNT          102 a          107 c          145 g          117 t
ORIGIN      
        1 acatgggggg tgttttcatt tgtgatcagc actgaacaca gaagactcat catggagttt
       61 ggcctgagct gggttttcct tgttgctatt ttaaaaggtg tccagggtga cgtgcagctg
      121 gtggagtctg ggggcggctt ggcaaagcct ggggggtccc tgagactctc ctgtgcagcc
      181 tctggattca gcttcagtta ctactggatg tactgggttc gccaggcacc aggaaagggg
      241 ctggagtgga tctcagttat tgatagtggt ggtgataaca catactatgc agactccatg
      301 aagggccgat tcaccatctc cagagagaac gccaagaaca cactgtatct tcaaatgaac
      361 agcctgactg ctgaggacac ggctgtctac ttctgtgcga gagtcagggg gggtatagca
      421 gggtactttg actactgggg ccagggagtc ctggtcaccg tctccccagc c
//
LOCUS       KCXD01004665             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15633:18144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004665
VERSION     KCXD01004665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15633:18144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63147.1"
                     /translation="CARVDCSGGVCFFDYW"
     D_segment       443..461
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          114 c          154 g          128 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggaa tctggaggag gcctggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtggctatgg
      241 catgaactgg gtccgccagg ctccagggaa gggactggat tgggtgtcaa ttatatcgtt
      301 tgatggaact aagaaatact acgcagactc tgtgaaggac cggttcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacagcctg aaattggagg acacggccgt
      421 gtattactgt gcgagagtgg actgtagtgg tggtgtctgc ttttttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004666             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14610:3882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004666
VERSION     KCXD01004666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14610:3882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63148.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       404..417
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          133 c          141 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacttgcgt tgtctctggc
      181 cactccatca gcagtggcta ccactggggc tggatccgtc agcccccagg gaagggactg
      241 gactatattg gctatatcag tggtagtagt gggagcacct actacaagcc ctccctcatg
      301 agtcgagtca tcatttcaag agacacgtcc cggaatgagt tctccctgag gctgaggtct
      361 gtgactgtcg cggacacggc cgtgtattat tgtgcgagac gagatagctg gaacaacggg
      421 gggagccttg actactgggg ccagggattc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004667             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4202:19713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004667
VERSION     KCXD01004667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4202:19713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63149.1"
                     /translation="CARRKYSGYTYGGANFDFW"
     D_segment       402..415
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           96 a          133 c          148 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgag ggcttcggag gccctgtccc tcacctgcac tgtctctggt
      181 ggctccatga gcggttacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg gtatcggtgg tggtagtggg agcaccgatt acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtacaag aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcaagaagga aatacagcgg gtacacgtac
      421 ggaggggcga actttgactt ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004668             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19570:9517
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004668
VERSION     KCXD01004668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19570:9517"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63150.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          102 a          125 c          154 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggaatctggg ggcggcttgg cacagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagt ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acaatggtgg
      301 ggatactacc ttctatgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtctcttc aaatggacgg cctcagagct gaggactcgg ctgtctatta
      421 ctgtgcgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004669             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11735:8339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004669
VERSION     KCXD01004669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11735:8339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63151.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       426..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          146 c          146 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgtcaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tgggaaaggg cttgagtgga tgggagttgt tgatcctgtc aatggtgaag aaattcacgc
      301 agagaacttc cagggcagag tcaccatgac cgaggacacg tcgacagaca cagcctacat
      361 ggacttgacc agtctcagat ctgaggacac ggccatctat tactgtgcga cagggaggat
      421 cggtggcagc ggctggtcca acctcttcac cggtttggaa tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004670             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18272:2482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004670
VERSION     KCXD01004670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18272:2482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63152.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          139 c          136 g          102 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgagtttcag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaag ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagcctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcaat tggctttttt ggtacttcga tttttggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004671             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12785:22007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004671
VERSION     KCXD01004671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12785:22007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63153.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       415..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          113 a          137 c          144 g          103 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attcacgttc agcaccgatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga ttggatggga ggggtcatcc ctcttatggg tacaaccaac tacgcacaga
      301 agttccaggg cagagtcacg tttaccgcgg acacgtcact aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattattg tgcgaaatcc gtgaattacg
      421 aggaagataa cggttactat ataccgacgc agtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01004672             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16603:12983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004672
VERSION     KCXD01004672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16603:12983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63154.1"
                     /translation="CAREYCTSSACAGFFDSW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          102 a          131 c          145 g          107 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag atttcctgca
      181 aggcttctgg gttcaccttc gacaactatg gtgtcaactg ggtgcgtcag gcccctggac
      241 aagggcttga gtgggtgggg gtgatcatcc cccttattgg tataaccaat tatgtagaga
      301 gtgtccaggg tagagtcacg attaccgcgg acacgtccac aaacacagcc tacatggagg
      361 tgagcagcct gagatctggg gacacggcca tctattactg tgcgagagaa tactgtactt
      421 ctagtgcttg cgccggattc tttgactcct ggggccaggg agtcccggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004673             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15966:17928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004673
VERSION     KCXD01004673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15966:17928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63155.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          118 c          150 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagaaatatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004674             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19962:15571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004674
VERSION     KCXD01004674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19962:15571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..522
     V_segment       153..444
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <438..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63156.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       449..463
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..522
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT           98 a          159 c          143 g          124 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg ccgaggtgca gctggtgcag tctggagcag
      181 aggtgaagag gcccggggaa tctctgagga tctcctgtca gacttctgga tacaattttg
      241 ccaactactg gatcgcctgg gtgcgccaga tgcccgggaa aggcctggag tggatgggga
      301 tcatctatcc tggtgattct gacaccaagt acggcccgtc cttcgaaggc caggtcacca
      361 tctcagccga caagtccagc agcaccgcct acctgcagtg gagcagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagactct ggggtgatta ttacgcactc cagtactact
      481 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004675             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4353:15932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004675
VERSION     KCXD01004675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4353:15932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..483
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63157.1"
                     /translation="CANGVAGLDFW"
     D_segment       429..434
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          100 a          118 c          159 g          108 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tatgctatcc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ctcaggtgtt agtagtggtg
      301 gtaacacata ctacgcagac tccgtgaagg gccgattcgc catctccaga gacgactcaa
      361 agagtacggt ctccctgcaa atgaacagcc tgagagctga ggacacggcc gtgtattact
      421 gtgcgaacgg ggtggcaggc ttagacttct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01004676             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9126:17766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004676
VERSION     KCXD01004676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9126:17766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..475
     V_segment       124..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63158.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       407..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          115 a          134 c          135 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcagagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctgatgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggttaccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttga gtggatggga agtgttgatc ctgtatatgg tgaaatgaaa
      301 gagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagt
      361 agcctgagat ctgaggatac ggccgtgtat tattgtgcag tcggcaatag cggtagctgg
      421 atctcctggt ccttcgatgt ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01004677             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18557:15140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004677
VERSION     KCXD01004677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18557:15140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63159.1"
                     /translation="CARDKGYSAVRRFDVW"
     D_segment       405..411
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..465
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           88 a          141 c          135 g          103 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggtaactcc tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tacctttgat gctgttggaa gcaccaatta caacccctcc ctcacgagtc
      301 gagtcaccat ttcaacagac acgtccaaga tccagttctc cctgaggctg agctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagataa gggttacagt gctgttagac
      421 ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004678             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6494:9543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004678
VERSION     KCXD01004678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6494:9543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63160.1"
                     /translation="CATGYSGSWNHWYFDVW"
     D_segment       407..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          115 a          139 c          132 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag tatagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgacttatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgaccct gcatatggtg aaatgaaaca
      301 cgtagacagg gtctccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgtgca accggatata gtggcagctg
      421 gaaccactgg tacttcgatg tctggggccc tggcacccca gtcaccatct cctcagcc
//
LOCUS       KCXD01004679             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15174:15015
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004679
VERSION     KCXD01004679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15174:15015"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63161.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       445..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          109 c          155 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcagtttca gtaattatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcag ttatgtcatc
      301 tgatggaact aagaaattct acgcagactc tgtgaaggtc cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacagcctg aaatcggagg acacggccgt
      421 atattattgt gggagagatg ataatggggt gattatcgac tactggggcc agggagtcct
      481 ggtcaccgtc acctcagcc
//
LOCUS       KCXD01004680             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6348:13845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004680
VERSION     KCXD01004680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6348:13845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63162.1"
                     /translation="CARDVYGTGLDYW"
     D_segment       442..447
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          110 c          157 g          122 t
ORIGIN      
        1 acatgggggg tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgt agcctctgga ttcagtttca gtggctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatctcgta
      301 tgatgaaact aagaaatatt acgcagactt tgtgaaggac cgattcaccg tctccagaga
      361 caatgccaag aacatgctat atattcaaat gaacaacctg aaattggaag acacggccgt
      421 gtattactgt gcgagagatg tctatggcac gggacttgac tactggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004681             378 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:22126:15199
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004681
VERSION     KCXD01004681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 378)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 378)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:22126:15199"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..376
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..376
     V_segment       10..301
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <295..>345
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63163.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       309..315
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       328..376
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        377..>378
                     /gene="IGHG"
BASE COUNT           87 a           95 c          111 g           85 t
ORIGIN      
        1 acatgggctg aggttcagtt ggtgcagtct ggggctgagg tgaagaagcc tggggcctca
       61 gtgaaggtct cctgcgaggt ttccggatac accttcaccg aactgtccat ccactgggtg
      121 cgacaggccc ctggaaaagg ccttgagtgg atgggaagtg ttgatcctga atatggtgaa
      181 atgataaacg cagaaaagtt ccagggcaga gtcaccttga ccgaggacac gtctacagga
      241 acggcctaca tggagctgat cagcctgaga tctgaagaca cggccgtgta ttactgtgcg
      301 acatcaccca gcggcaattg gcttttttgg tacttcgatt tttggggccc tggcacccca
      361 atcaccatct cctcagcc
//
LOCUS       KCXD01004682             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:25020:7642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004682
VERSION     KCXD01004682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:25020:7642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63164.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          136 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctatccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004683             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21861:8574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004683
VERSION     KCXD01004683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21861:8574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63165.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       416..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          119 a          142 c          134 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag gagcctgggg cctcagcgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 acacacagag ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctaa gatctgagga cacggccctg tattattgtg cagtcgggta
      421 tagcggccga tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004684             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17129:23001
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004684
VERSION     KCXD01004684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17129:23001"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63166.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          110 a          121 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcaattatt actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atcatggtgg
      301 ggaaagtaca tactatgccg actccgtgaa gggcagattc accctctcca gagagaacgc
      361 caagaacaca ctatatcttc aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004685             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9295:10559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004685
VERSION     KCXD01004685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9295:10559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63167.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          135 c          136 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcactg tctctggtgg
      181 ctccttcagt ggttactact ggacctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatg tcaagagaca cgtccaagaa tcaattctcc ctgaagatga cctctatgac
      361 cgccgcggac acggccgttt atttctgtgc cagagatgcg ggagtgggag ccacaatcct
      421 ttattactat gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004686             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16520:20970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004686
VERSION     KCXD01004686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16520:20970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..445
     V_segment       85..378
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63168.1"
                     /translation="CTRAPIEAANRFDVW"
     D_segment       390..396
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..445
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          106 a          128 c          121 g           92 t
ORIGIN      
        1 acatggggga gagcacagtt tctcaccatg gacttgacct ggaagatcct cctcttggtg
       61 acagcagcca caggtgccca ctcccaggtg caactggtgc agtctggggc tgagattaag
      121 cagcctgggg cctcagtgaa gctctcctgc aaggcttctg gatatacctt ctttaactac
      181 tacatgcact gggtgagaca ggcccctgga caaggccttg agtgggtagg actgatctcc
      241 ccttacaatg gttacaaagc caacgcacag agcttccagg gcagagtcac cataactacg
      301 gacacgtcca cgagcacagg ctacatggaa ctgagcagcc tgacatctga ggacacagcc
      361 gtttattact gtacgagagc ccctattgaa gcagcaaacc ggttcgatgt ctggggcccg
      421 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004687             353 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:25382:12582
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004687
VERSION     KCXD01004687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 353)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 353)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:25382:12582"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..351
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..351
     V_segment       8..290
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63169.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       300..305
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..351
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        352..>353
                     /gene="IGHG"
BASE COUNT           83 a           81 c          107 g           82 t
ORIGIN      
        1 acatgggggt ggagtctgga ggaggcttgg ttcagcctgg ggggtccctg agactctcct
       61 gtgcagcctc tggattcacc ttcagtacct atggcattca ctgggtccgc cagactccag
      121 ggaaggggct ggagtgggtg gcagttatat cgtatgatga aactaagaca tactacgcag
      181 actctgtgag ggaccgattc accatctcca gagacaattc caaaaacatg gtgtattttc
      241 aaatgaacaa cctgaaattg gaggacacgg ccgtatatta ctgtgtgaga gatgtcaggg
      301 gaacggggtt tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004688             540 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17100:11470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004688
VERSION     KCXD01004688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 540)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17100:11470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    169..538
                     /note="immunoglobulin heavy chain variable region"
     V_region        169..538
     V_segment       169..462
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <454..>507
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63170.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       464..470
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       497..538
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        539..>540
                     /gene="IGHG"
BASE COUNT          126 a          149 c          154 g          111 t
ORIGIN      
        1 acatggggac tggtgtctgc cgaggtaaat acagatctgt cctcgtccag agagcatcac
       61 acaacaacca catccctccc ctacagaagt cccagagcac agcacctcac catggactgg
      121 acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga ggtccacctg
      181 gtacagtctg gggctgaagt gaagaagcct ggggcctcag tgaaggtctc ctgcaaagtt
      241 tccggataca ccttcaccga tttatccatg cactgggtgc gacaggcccc tggaaaaggg
      301 cttgagtggg tgggaggtgt tgatactgta tctgatggaa tgatatacgc agaaaacttc
      361 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggagctgagc
      421 agcctgagat ctgaggacac ggccgtttat tactgtgcga gaggtgtgac agcagacgtc
      481 ttcggtttcc tcgggcttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004689             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14911:17560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004689
VERSION     KCXD01004689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14911:17560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63171.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          127 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggcg tggatctcag gtattaacgc
      301 tggtggggat accacatact atgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccagg aacacactgc atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004690             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:25485:14091
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004690
VERSION     KCXD01004690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:25485:14091"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63172.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          143 c          132 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga accctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacat
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacctca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004691             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7686:15350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004691
VERSION     KCXD01004691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7686:15350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..492
     V_segment       140..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63173.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          115 c          148 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgtg gtgcagctgg tggagtctgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaacc tttggcatgc
      241 attgggtccg ccaggctcca gggaagggac tggagtgggt ggcagttata tcgtctgatg
      301 gaggttacaa atactacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caactgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004692             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14368:9207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004692
VERSION     KCXD01004692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14368:9207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..521
     V_segment       143..434
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63174.1"
                     /translation="CVRDIPYYNFWSGYDSGLDAW"
     D_segment       445..469
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..521
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          111 a          124 c          158 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtattt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctccgga ttcatcttca gtgaccacta
      241 catggactgg gtccgccagg ctccagggaa ggggctggaa tgggtctcac gtgttactaa
      301 tgatggtggt agcacatggt acgcagactc cgtgaaggac agattcacca tctccagaga
      361 gaacgccgag aacacccttt atcttcaaat gaaaagcctg agagctgagg acacggctgt
      421 ctatttttgt gtgagagata ttccgtatta caatttttgg agtggttatg actccggttt
      481 ggatgcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01004693             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24845:10993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004693
VERSION     KCXD01004693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24845:10993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..497
     V_segment       140..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63175.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       443..448
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          115 c          161 g          120 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagtt ggtggagtct gggggctgct tggcacagcc
      181 tggggggtcc ctgagactct cctgttcagc ctctgggttc accttcagta ggcactggat
      241 gaactgggtc cgccaggctc caggaaaggg gctagagtgg gtctccggta ttaatagtgg
      301 tggggatact acatactacg tagactccgt gaagggccga ttcaccatgt ccagagacaa
      361 ttcaaagaac actctctccc tgcaaatgaa cagcctgaga gcggaggaca cggccgtgta
      421 ttattgtgtg caaggggaaa tttttggagt gggtttggat ttctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004694             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:10742:10012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004694
VERSION     KCXD01004694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:10742:10012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63176.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          148 c          132 g           94 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacat
      301 tccagggcag agtcttcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac gcggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01004695             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27073:12088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004695
VERSION     KCXD01004695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27073:12088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63177.1"
                     /translation="CARRWAGYGLDSW"
     D_segment       401..406
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..455
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           84 a          136 c          137 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccctcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atcgctggta gcagtgggag caccgactat aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa tcagttctcc ctgaatctga tctctgtgac
      361 cgccgcggac acggccgcat attactgtgc gaggcgatgg gctggatacg gtttggattc
      421 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004696             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:19512:20519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004696
VERSION     KCXD01004696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:19512:20519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63178.1"
                     /translation="CTRDVYGSGFDYW"
     D_segment       438..446
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          112 c          153 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctact
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggcct ggttcagcct
      181 cgggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttttggcatg
      241 cactgggtcc gacaggctcc agggaagggg ctggagtggg tggcagttat gtcgtctgac
      301 ggaagtagga tatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 ttcaagaaca tgctatatct tcaaatgaac aacctgaaat ttgaggacac ggccgtgtat
      421 tattgtacga gagatgtcta cggtagtgga tttgactact ggggcctggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004697             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5507:9306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004697
VERSION     KCXD01004697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5507:9306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63179.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          137 c          127 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggtccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccaggcaagg gactggagtg
      241 gattggatat atctctggtg cttatgggag caccaactac aacccctccc tcaagagtcg
      301 agtcaccatt tcgacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004698             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:11285:6793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004698
VERSION     KCXD01004698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:11285:6793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63180.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          115 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatatcgt
      301 atgatgaaac taagaaatac ttcgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004699             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16882:5209
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004699
VERSION     KCXD01004699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16882:5209"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63181.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          115 c          149 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgaactgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgacg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct ttggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggactgggtg gcagttattt cgtatgatga
      301 aactaagaaa tacttcgcag actctgtgag ggaccggttc accatctcca gagacaattc
      361 caaaaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtatatta
      421 ctgtgcgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag ccctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004700             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10439:4935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004700
VERSION     KCXD01004700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10439:4935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63182.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          137 c          135 g          101 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc aggtcccaga tgggtcctgt cccaggtgca gctgcgggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcagctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagccg ccatttcaaa agacacgtcc aacaatcaac tctccctgag gttgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccatcttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004701             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7191:10178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004701
VERSION     KCXD01004701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7191:10178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63183.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       416..423
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          100 a          134 c          145 g          100 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag ctctcttgca
      181 aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcgtcc ctcttgttgg aacaacaaac tccgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagtc tacatggagt
      361 tgagcagcct gagatctgag gacacggcca tgtattactg tgcgagaggc ctgggtagca
      421 gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01004702             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19696:6091
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004702
VERSION     KCXD01004702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19696:6091"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63184.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          109 a          122 c          156 g          128 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgagc aggggctgga gtggatctca gctattgata
      301 gtgctggtag tagtaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004703             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16738:20796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004703
VERSION     KCXD01004703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16738:20796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..374
     V_segment       8..299
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63185.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       313..319
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       325..374
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           89 a           99 c          108 g           80 t
ORIGIN      
        1 acatggggag gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
       61 gaaggtctcc tgcaaagttt ccggatacac cttcaccgaa ttatcattgc actgggtgcg
      121 ccaggcccct ggaaaagggc ttgagtgggt gggaagtgtt gaccctgcat atggtgaaat
      181 gatacacaca gagatattcc agggcagaat caccatgacc gaggacacgt caacagacac
      241 agcctacatg gagctaagca gcctgagatc tgaggacacg gccgtttatt actgtgcgat
      301 atcatccagc ggcacctggc tattctggta cttcgatgtc tggggccctg gctccccaat
      361 caccatctcc tcagcc
//
LOCUS       KCXD01004704             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9565:19383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004704
VERSION     KCXD01004704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9565:19383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63186.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          114 c          152 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggagggg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcatc
      301 tgatggaagt aagaaatact acgcaaactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatagtat atcttcaaat gaacagcctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004705             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16644:18529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004705
VERSION     KCXD01004705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16644:18529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63187.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          119 a          146 c          143 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caagttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgacatctg aggacacggc catctacttc tgtgcgacag
      421 ggaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctct tcagcc
//
LOCUS       KCXD01004706             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:11405:11960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004706
VERSION     KCXD01004706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:11405:11960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63188.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       418..424
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          137 c          142 g          101 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagtcccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtacag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggag gtgttgatac tgtatctgat ggaatgatat
      301 acgcagaaaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt tttttactgt gcgagaggtg
      421 tgacagcaga cgtcttcggt ttcctcgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004707             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16579:16426
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004707
VERSION     KCXD01004707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16579:16426"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..496
     V_segment       139..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63189.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       442..447
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          108 a          117 c          161 g          112 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggcggctt ggcaaagccg
      181 ggggggtccc taagactctc ctgtgcagcc tctggattca ccttcagtag gcactggatg
      241 aactgggtcc gccaggctcc aggaaagggg ctggagtggg tctcaactat taatagtggt
      301 ggggacaaca catattacgc agactccgtg aagggccgac ttaccatttc cagagacaac
      361 tcaaagaaca cgctcctcct gcaaatgaac agcctgagag tggaggacac ggccgtgtat
      421 tactgtgttc aaggggaaat ttttggagtg ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01004708             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13439:7360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004708
VERSION     KCXD01004708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13439:7360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63190.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       444..450
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          104 a          126 c          156 g          120 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc cagaattccc aggtgtttct gttcggcgat
       61 cagcactaaa cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc
      121 ttttgaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 cgggggggtc cctgagactc tcctgcgcag tctctggatt cagtttcagt cactacttca
      241 tgagctgggt ccgccagact ccagggaagg gactggagtg gatctcagtg attaacagtg
      301 gtggagatac cacacactat gcagactccg tgaagggcag attcaccatg tccagagaga
      361 acgccaggaa cacactgtct cttcaaatgg acggcctgag acctgaggac tcggctgtct
      421 attactgtgc gagagatcga cgtgtacagt cgttatcctg gttcgatgtc tggggcccgg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004709             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:4610:20271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004709
VERSION     KCXD01004709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:4610:20271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63191.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          141 c          150 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtaaa
      181 ggtctcctgc caggtttccg gatacacctt cagtgaaatg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgttgct cctgtaaatg gtgaaataat
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagcc tgagatctga ggacacggcc gtgtattact gtgcgacagg
      421 gaggttcggg agcagcgtct ggtccagcct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004710             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12459:7707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004710
VERSION     KCXD01004710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12459:7707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..461
     V_segment       113..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63192.1"
                     /translation="CARADRGSSIDYW"
     D_segment       412..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>467
                     /gene="IGHG"
BASE COUNT          107 a          106 c          139 g          115 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaagactc accatgaagt
       61 ttgggctgag ttgggttttc cttgttgcaa ttttaagagg tgtccagtgt ggggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc ctggggggtc cctgagactc tcctgtgtag
      181 cctctggatt caccttcaga acctatggca tgcactgggt ccgccaggcc ccagggaagg
      241 ggctggagtg ggtggcggtt atatcatatg atgatgacaa gaaatattac gcagactctg
      301 tgaaggaccg attcaccatc tccagagaca attccaagaa cattctttat cttcaaatga
      361 acaacctgaa attggaggac acggccgtgt tttattgtgc gagagcggat cgcggcagtt
      421 caattgacta ctggggccag ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01004711             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11068:16467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004711
VERSION     KCXD01004711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11068:16467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63193.1"
                     /translation="CVRVHDYAMYYFDYW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          114 c          152 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatggaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaatatggta tatcttcaaa tgaataccct gaaatcggag gacacggccg
      421 tgtattactg tgtgagagtc catgactacg ccatgtacta ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004712             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9133:2215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004712
VERSION     KCXD01004712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9133:2215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63194.1"
                     /translation="CAGAHSGSWTNWSFDLW"
     D_segment       422..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          141 c          145 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gagggtcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agccaggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atattcggtc accgaagtgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctctatatgg tgaaataata
      301 gaaggagaga agttcccggg cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgggagcc
      421 catagcggca gctggaccaa ctggtccttc gatctctggg gccctggcac tccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004713             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:17703:14756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004713
VERSION     KCXD01004713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:17703:14756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63195.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       445..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          110 c          157 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cagcttcagt atctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atgtcgaatg
      301 atggaagtaa gaaatactac acagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa aatgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgcgc gagagacgat tttggcagcg gcttagggta ctggggccag ggagccctgg
      481 tgaccgtctc ttcagcc
//
LOCUS       KCXD01004714             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23440:10396
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004714
VERSION     KCXD01004714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23440:10396"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..438
     V_segment       69..362
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63196.1"
                     /translation="CAREYCTTHDCAGFFDYW"
     D_segment       363..374
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           95 a          114 c          131 g          100 t
ORIGIN      
        1 acatggggac catggactgg acctggaggc tcctctttgt ggtggcagca gctacaggtg
       61 tccagtccca ggtccagttg gtgcagtccg gggctgaggt caagaagcct ggggccgcag
      121 tgaaggtttc ctgcaaggct tctggattca ccctcgacaa ctatggtatc aactgggtgc
      181 gacaggcccc tggacaaggg cttgagtgga tgggagtgat catcccccat gttggtataa
      241 taaattacgg tgagcggttc caggacagag tcacgattag cgcggacacg tccatgaata
      301 tagcctacat ggacctgacc agcctgaaat ccgacgacac ggccatctat ttctgtgcga
      361 gagaatactg tactactcat gattgcgccg gcttctttga ctactggggc cagggagtcc
      421 tggtcaccgt ctcttcagcc
//
LOCUS       KCXD01004715             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9918:16057
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004715
VERSION     KCXD01004715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9918:16057"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63197.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       409..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           90 a          139 c          143 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcgggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagtaatt ggtggagctg gatccgccag tccccaggga agggactgga
      241 atggattggg ggtgtctatg gtagtggtgg gaataccgaa tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaagg acacgtccaa gaaccagttc tccctgaagc tgaactctgt
      361 gaccgccgcg gacaccgccg tgtattactg tacgagagaa tggggcgcta tagcggcagt
      421 tgggcctgtc cttgcctcct ggggccaggg tgtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004716             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:10505:4935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004716
VERSION     KCXD01004716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:10505:4935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63198.1"
                     /translation="CARADRGSSIDFW"
     D_segment       288..294
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           80 a           84 c           97 g           82 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagcctgg ggggtcccta agactctcct gtgcagcctc
       61 tggattcacc ttcagtacct atggcatgca ctgggtccgc caggctccag ggcaggggct
      121 ggagtgggtg gcggttatat cttatgatga tgataagaaa tactacacag actctttgaa
      181 ggaccgattc accatatcca gagacaattc caagaacact ctttatcttc aaatgaacaa
      241 cctgaaattg gaggacacgg ccgtgtatta ttgtgcgaga gcggatcgcg gcagttcaat
      301 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004717             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19025:18300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004717
VERSION     KCXD01004717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19025:18300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63199.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          110 a          140 c          145 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg cagtgaagag gcctggggcc tcagttaagg
      181 tctcctgcaa ggtttccgga tactccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtgtatggt gaagaaatac
      301 acgcagagaa tttccaggac agagtcacca tgaccgagga cacgtccaca gacacagcct
      361 acatggagct gagcagcctg agacgtgagg acacggccgt gtatttctgt gcggcgggcc
      421 ttggggggta tttagttctt actgaatacc tcgaattctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01004718             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23049:3454
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004718
VERSION     KCXD01004718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23049:3454"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63200.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          143 c          132 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac caaattatcc atccactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccct
      481 ctcctcagcc
//
LOCUS       KCXD01004719             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13843:11562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004719
VERSION     KCXD01004719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13843:11562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..439
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <431..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63201.1"
                     /translation="CTRVKYYYDSGYYVGPFDYW"
     D_segment       446..469
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       479..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          111 a          128 c          150 g          134 t
ORIGIN      
        1 acatggggag ctctgggaga ggagccacag ccccgggatt cccagctgtc tccacttggt
       61 catgaacact gaactcagaa gacgcaccat ggagtttgtg ctgagtttgg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 aaagcctggg gggtccctga gactctcttg tgtagcctct gggttctcct tcagtaccta
      241 tcctttacac tgggtccgcc aggctcccgg gaagggtctg gagtgggtct cagttattag
      301 tgaaactggt ggaaccacat actacgcaga ctctgtgaag ggccgcttca ccatctccag
      361 agacaacgcc aagaactcac tgtttctgca aatgaacagc ctgagagccg aggacacggc
      421 cgtctattat tgtactagag tcaaatatta ctatgatagt ggttattacg tcgggccatt
      481 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004720             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14544:15996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004720
VERSION     KCXD01004720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14544:15996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63202.1"
                     /translation="CARDESAWNYPFDYW"
     D_segment       408..417
                     /gene="IGHD1-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           90 a          143 c          131 g          101 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gaccggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcactcactg gtggagctgg atccgccagc cccccgggaa gggactggag
      241 tggattggac gtatctctgg tactagtggg aggactgact acaacccctc cctcgagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccttgaagtt gaattctgtg
      361 accgccgcgg acacggccct atattactgt gcgagagatg agtccgcctg gaactacccc
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004721             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22014:12181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004721
VERSION     KCXD01004721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22014:12181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63203.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       419..438
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          108 a          141 c          146 g          107 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 tcaggtccag ctggtgcagt ccggggctga gatggagaag cctggggcct cagtgaagct
      181 ctcctgtaag gcttctggat acaccttgag catctatgtc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg catcttccct cttgttggta caacaaacta
      301 cgcacagaag ttccagggca gagtcacgat taccgcggac acgtccacaa gcacagccta
      361 catggacctg agcagcctgg gatctgggga cacggccgtc tattattgtg cgagaggcta
      421 ctgtactggt agtggttgta accttacatt caaccggctc gatgtctggg gcccgggagt
      481 cccggtcacc gtctcctcag cc
//
LOCUS       KCXD01004722             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19551:17827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004722
VERSION     KCXD01004722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19551:17827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..432
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63204.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       439..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          112 a          119 c          156 g          118 t
ORIGIN      
        1 acatgggggg agagaggagc cttagccctg gatttcaagg cacttccacc tggggatcag
       61 cactgaacac agaggaccca ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggaggct tggtccagcc
      181 tggagggtct ctgagactct cctgtgtagc ctctggattc agcttcagaa gttacgaaat
      241 gagttgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatata ttagtcacac
      301 tggtgaaacc atataccacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtata
      421 ttactgtact agaaaccgga atactgtaat gattgggtgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004723             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19473:19591
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004723
VERSION     KCXD01004723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19473:19591"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63205.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..412
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           86 a          134 c          140 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacttgtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttatta ctggggctgg atccgccagc ccccagggga ggggctggag
      241 tggattgggt atatcagtgg gagtggtggg agtaccgact acaagtcttc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gaggtctctg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtcc ggggcgtaac tatccactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004724             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22376:2392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004724
VERSION     KCXD01004724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22376:2392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63206.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       428..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          143 c          149 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccgtca gcgaattgtc catgcactgg gtacgacagg
      241 cccctgggaa agggcttgag tggatgggag ttgttgatcc tgtcaatggt gaagaaatac
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtggaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtag cagcggctgg tccaacctct tcaccggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01004725             422 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12186:11820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004725
VERSION     KCXD01004725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 422)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 422)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12186:11820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    45..418
                     /note="immunoglobulin heavy chain variable region"
     V_region        45..418
     V_segment       45..344
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <336..>389
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63207.1"
                     /translation="CARTSYGGSYYFFYFDYW"
     D_segment       355..369
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       374..418
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        419..>422
                     /gene="IGHG"
BASE COUNT           95 a          100 c          116 g          111 t
ORIGIN      
        1 acatgggggt tttccttgtt gctattttaa aaggtgtcca gtgtgaggtg ctactggtgg
       61 agtctggggg aggcttggtc cagcctggcg ggtccctgag actctcctgt gcagcctctg
      121 gattcacctt cagtgactat gccatgagct gggtccgcca gacttctggg aaaggactgg
      181 agtgggttgg ctatattaga agcaaatcta ataattacgc gacagaatac gccgcatcgg
      241 tgaaaggcag gttcaccatc tccagagatg attcaaagaa cacgctatat ctacaaatga
      301 ccagcctgaa aaccgaggac acggccgtgt attactgtgc tagaacttcc tatggtggta
      361 gttattactt cttctacttt gactactggg gccagggagt cctggtcacc gtctcctccg
      421 cc
//
LOCUS       KCXD01004726             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17910:2167
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004726
VERSION     KCXD01004726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17910:2167"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63208.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       441..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          120 a          143 c          146 g           98 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaactggt gcagtctggg gctgaaatga agaagcctgg ggcctcagtt
      181 agggtctcct gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata
      301 atacacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tgcagacaca
      361 gccttcatgg agttgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgaaa
      421 ggggggttcg gaaccagcgt ctggtccaac ctcttctacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004727             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15520:4574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004727
VERSION     KCXD01004727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15520:4574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63209.1"
                     /translation="CARSSSGSWINWYFDIW"
     D_segment       425..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          124 a          143 c          136 g           90 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gacacacctt caccgagcta tccatccact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgaaataag
      301 gaacacagac aacttccagg gcagagtcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga ggacacggcc gtgtattatt gtgcgagatc
      421 atccagcggc agctggataa actggtactt cgatatctgg ggcccaggca ccccagtcac
      481 catctcctca gcc
//
LOCUS       KCXD01004728             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18246:16043
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004728
VERSION     KCXD01004728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18246:16043"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63210.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       451..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          103 a          126 c          157 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa caaaccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agtttctact
      241 acatgagctg ggtccgccag cctccaggga agggtctgga gtggatctca ggtattaacg
      301 ctggtgggga tggcacatac tctgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg catcttcaaa tggacagcct gagaactgag gacacggctg
      421 tctatttctg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004729             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14153:19969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004729
VERSION     KCXD01004729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14153:19969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63211.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          121 a          141 c          133 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt gtcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggttaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaatttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacttgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004730             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21341:10258
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004730
VERSION     KCXD01004730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21341:10258"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63212.1"
                     /translation="CARRGIAAGWSFDYW"
     D_segment       450..455
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          114 a          116 c          158 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaaa ctctcctgcg cagcgtctgg atttagtttc agttcctact
      241 acatgaactg ggtccgccag gctccaggga aggggctgga gtggatttca ggtattgaca
      301 atggtggggg gaacacatac tatacagact ccgtgaagga cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagaactgag gacatggctg
      421 tctattactg tgcgagaaga gggatagccg ctggatggag ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004731             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16576:11243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004731
VERSION     KCXD01004731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16576:11243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..342
     V_segment       1..266
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63213.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       270..278
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..342
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           70 a           98 c          100 g           76 t
ORIGIN      
        1 gactggtgaa gcctctggag accctgtccc tcacctgcgc tgtctctggt ggctccatga
       61 gcagtcacta ctgcagctgg atccgccagt ccccagggaa gggactggag tggattggac
      121 ggatctctgg tagtggtggg agcaccgact acaacccctc cctcaagagt cgagtcacca
      181 tctcaacaga cacgtccaag aaggagatct ccctgaagct gagctctgtg accgccgcgg
      241 acacggccgt gtattattgt gcgagagaag actatggtgg taattattat tttaaccggt
      301 tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004732             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12625:8780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004732
VERSION     KCXD01004732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12625:8780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..483
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63214.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>487
                     /gene="IGHG"
BASE COUNT          116 a          143 c          128 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggct acaccttcgc cgaattgccc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg ttttgcttct atatatggtg aaataataca
      301 tacagagaga ttccagggca gagtcaccat gacagcggac acgtctatag acacagccta
      361 catggaactc agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctccgcc
//
LOCUS       KCXD01004733             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15442:11970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004733
VERSION     KCXD01004733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15442:11970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63215.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       406..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           90 a          142 c          128 g          111 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctgct
      181 gactccatca ccagtagctt ctggaactgg atccgccagc ccccagggag ggggctggag
      241 tggattggct atatctctgg tgctactggg agttccagct acaacccctc cctcaagagt
      301 cgagtctcca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gaactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgacgatga ttacggttct
      421 tattaccttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004734             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:11346:9065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004734
VERSION     KCXD01004734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:11346:9065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63216.1"
                     /translation="CAGRTWSGGTPLLDYW"
     D_segment       427..434
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          135 c          134 g          107 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctggagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgca ctgtctctgg
      181 tttctccatc agcagtgact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatatatg gaagaagtgg gagcatctac tataatccct ccctcaacag
      301 tcgagtcacc ttttcaacag acacgtccaa gaaccagttc tccttgaagc tgaactctgt
      361 gaccgccgca gacgcggccg tttattactg tgcggggcgg acctggagtg gtggcacgcc
      421 cctccttgat tattggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004735             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:6928:11140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004735
VERSION     KCXD01004735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:6928:11140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..518
     V_segment       143..432
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63217.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       470..476
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..518
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          112 a          124 c          162 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtattt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca cctggtgcag tctgggggcg gcttgacaaa
      181 gccggggggg tccctgagac tctcctgtgc agcctccgga ttcaccttca gtgactacta
      241 tatggactgg gtccgccagg ctccagggaa ggggctggag tgggtctcac gaatcggtca
      301 tgatggtggt agcacatggt acgcagactc cgtgaagggc agatttacca tttccagaga
      361 gaatgccaag aacacactgt ttcttcaaat ggacagcctg agaagtgagg acacagccgt
      421 atattactgt gccagagagc ggtttggggg aattggggta attatcttca actggatcga
      481 tgtctggggc ccgggagtcc tggtcaccgt cccctcagcc
//
LOCUS       KCXD01004736             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:24097:13560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004736
VERSION     KCXD01004736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:24097:13560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..484
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63218.1"
                     /translation="CARVRIAVPGTDYFFDYW"
     D_segment       413..422
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          110 a          138 c          138 g          100 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cagctgatac agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggcttctg gatacacctt cagcaccttt gccatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agggatcatc cctcttgttg aaataacaaa ttacgcacag
      301 aagttccagg gcagagtcac cattaccgcg gacacgtcca caagcacagc ctacatggag
      361 ctgaccagcc tgaaatctga ggacacggcc gtgtattact gtgcgagagt gcgtatagcg
      421 gttcctggaa cggactactt ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01004737             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11628:13461
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004737
VERSION     KCXD01004737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11628:13461"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..290
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63219.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       300..306
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..360
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           74 a           94 c          113 g           81 t
ORIGIN      
        1 acatgggggt ggagtctggg ggcggcttgg caaagcctgg ggggtccctg agactctcct
       61 gcgcagcctc tggattcagc ttcagttact acttcatgag ttgggtccgc caggctccag
      121 ggaaggggct ggagtggatc tcaggtatta ccagtggtgg ggataacaca tactctgcag
      181 actccgtgaa gggcagattc accatctcca gagagaacgc caagaccaca ctgtatcttc
      241 acatggacag cctgagagct gaggacacgg ctgtctatta ctgtgcaaga gatcgacgtg
      301 tacagtcgtt atcctggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01004738             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22716:11499
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004738
VERSION     KCXD01004738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22716:11499"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63220.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          140 c          150 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctgggact gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga gcttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggtcaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004739             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:7903:19112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004739
VERSION     KCXD01004739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:7903:19112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    60..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        60..344
     V_segment       60..268
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <260..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63221.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       270..276
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       303..344
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           84 a           97 c          100 g           65 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccgattta tccatgcact gggtgcgaca ggcccctgga aaagggcttg agtggatggg
      121 aggtgttgat actgtatctg gtggagagat atacgcagag aacttccagg gcagagtcac
      181 catgaccgag gacacggcca aagacacagc ctacatggag ctgaccagcc tgagatctga
      241 ggacacggcc gtttattact gtgcgagagg tgtgacggca gacgtcttcg gtttcctcgg
      301 gcttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004740             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21013:15723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004740
VERSION     KCXD01004740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21013:15723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63222.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          144 c          134 g           95 t
ORIGIN      
        1 actgggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catccactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcaccc tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcaccc
      481 tctcctcagc c
//
LOCUS       KCXD01004741             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18808:9589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004741
VERSION     KCXD01004741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18808:9589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63223.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          119 c          151 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactcggtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat tctatatctt caaatgaaca acctgaagtt ggacgacacg gccgtctact
      421 actgcgcgag agacgcattt ggcagcggct gtgactactg gggccggggc gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004742             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22405:20089
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004742
VERSION     KCXD01004742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22405:20089"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..510
     V_segment       135..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63224.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       430..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..510
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          104 a          124 c          159 g          125 t
ORIGIN      
        1 acatgggggg agacaggagc cttagccctg gattccaaga acttccactt tgggatcagc
       61 tctgaacaca gaggaccatg gagttggggc tgagctgggt tttccttgtt gctattttaa
      121 aaggtgtcca gtctgaggtg cagctggtgg agtctggggg aggcttggtc cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcagctt tggcgatcat ggcatgcact
      241 gggtccgcca ggctccggga aagggactgg agtgggtctc atccatcagt aatactggta
      301 aagccgtaca ctacgctgac tccgtgaagg gccgattcac catttccaga gacaacgcca
      361 agaactcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc gtgtattatt
      421 gttgtagcga ttactatagt ggtagttatt actattgggg ctacggcttg gattcctggg
      481 gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004743             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20621:3041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004743
VERSION     KCXD01004743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20621:3041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63225.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          108 a          123 c          155 g          128 t
ORIGIN      
        1 acatggggag ctctgagaca ggagtcttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtggagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgtagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagaaacac
      301 tggtaaaatc gtatactacg ctgactccgt gaagggccga ttcatcatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgaa cagcctgaga gtcgaggact cggccgtcta
      421 ttactgtact agaattggcg tcggatctct agcaccggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004744             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6800:14203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004744
VERSION     KCXD01004744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6800:14203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    170..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        170..430
     V_segment       170..350
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <349..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63226.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       365..378
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..430
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT          102 a          102 c          123 g          105 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgaactggg ttttccttgt
      121 tgctatctta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg ccaggcttct
      181 gggaaaggac tggagtgggt tggctatatt agaagccaat acaggaatta cgcgacagaa
      241 tacgccgcat cggtgaaagg cagattctcc atctccagag atgattcaaa gaacacgctt
      301 tatctacaaa tgagcagcct gacaaccgag gacacggccg tctattattg caccaccctc
      361 tatggtggta gttattacgt ggactacttt gactcctggg gccagggagt cctggtcacc
      421 gtctcctcag cc
//
LOCUS       KCXD01004745             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20786:13152
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004745
VERSION     KCXD01004745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20786:13152"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63227.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          128 c          154 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc
      301 tggtggggat accacatact ctgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004746             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17561:17329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004746
VERSION     KCXD01004746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17561:17329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..325
     V_segment       152..246
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <238..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63228.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       256..267
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..325
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           56 a          106 c           94 g           71 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtctcca tctcagccga caagtccatc
      181 agcaccgcct acctgcagtg gagcagcctg aaggcctcgg acaccgccac gtattactgt
      241 gcgaaagggg ggtggtgggg tgattatcca ccctcagact ggctcgatgt ctggggcccg
      301 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004747             418 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15718:6519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004747
VERSION     KCXD01004747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15718:6519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..416
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..416
     V_segment       56..346
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <338..>385
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63229.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       349..364
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..416
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        417..>418
                     /gene="IGHG"
BASE COUNT           81 a          103 c          133 g          101 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcaggtggtg gagtctgggg gcggcttggc aaagcctggg ggatccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtaccta tgctatgcac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtct cagccattag tgttggtggt agtacatact acgcagactc
      241 cgtgaggggc cgattcacca tctccagaga caactcagag agcacgctct ccctgcaaat
      301 gaacagcctg agtactgagg acacggccgt gtattactgt gccaaagggg atacagctac
      361 agtttattac ggtttggatt cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01004748             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:9761:16653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004748
VERSION     KCXD01004748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:9761:16653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63230.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          144 c          142 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tttattactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01004749             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14206:4954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004749
VERSION     KCXD01004749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14206:4954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63231.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          112 c          153 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacagctgg tggagtctgg aggaggcttg gttcagcctc
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgtctgatg
      301 gaagtagcat atactatgca gcctctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt tgaggacacg gccgtgtatt
      421 actgtgcgag agatgtgtac ggtagtgggt tagactactg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004750             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:23008:17909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004750
VERSION     KCXD01004750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:23008:17909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..516
     V_segment       141..440
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63232.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       443..449
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..516
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          116 a          123 c          158 g          121 t
ORIGIN      
        1 acatgggggg ggagaggaga cccagccttg ggattcccag gcgtctccac ttggtgatca
       61 gcactgaaca caagagactc accatggagt ttgtactgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggcgggtc cctgagactc tcctgtgcag gctctggatt caccttcagt gactatgcca
      241 tgagctgggt ccgccaggct tctgggaaag gactggagtg ggttggctat attagaagca
      301 aatcttacaa ttacgcgaca gaatacgccg catcggtgaa aggcaggttc accatctcca
      361 gggatgattc aaagaacacc ctacatctgc aaatgagcag cctgaaaatc gaggacacgg
      421 ccgtgtatta ctgtgctaga ggggatatac cggctataga ggcctactac ggtttggatt
      481 cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01004751             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14914:9735
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004751
VERSION     KCXD01004751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14914:9735"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63233.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       411..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          139 c          146 g          105 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggc tactgtactg
      421 gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004752             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11534:13579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004752
VERSION     KCXD01004752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11534:13579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63234.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       440..452
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatttttag aggtgtccag tgtgaagtcc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgcga ctctcctgtg cagcctctgg attcaccttc actacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaag taagaaatat tacgcagact ctgtgaagga ccgattcacc ttgtccagag
      361 acaataccaa gaacatgcta tatattcaaa tgaacaacct gaaattggag gacacggcca
      421 tgtattactg tgtgagagat gactacggta gcggcctcgg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004753             310 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24741:17375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004753
VERSION     KCXD01004753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 310)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 310)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24741:17375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..308
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..308
     V_segment       7..247
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <239..>277
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63235.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       258..267
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       268..308
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        309..>310
                     /gene="IGHG"
BASE COUNT           75 a           78 c           86 g           71 t
ORIGIN      
        1 acatgggaga ctctcctgtg cagcctctgg attcaccttc agtagttttg gcgtccactg
       61 ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt ctgatgaaag
      121 taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag acaattccaa
      181 gaacatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg tctattactg
      241 tgcgagagac gtatatggca gcggctgtga ctactggggc cagggagtcc tggtcaccgt
      301 ctcctcagcc
//
LOCUS       KCXD01004754             250 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:25728:8213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004754
VERSION     KCXD01004754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 250)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 250)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:25728:8213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..248
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..248
     V_segment       7..161
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <155..>217
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63236.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       184..191
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       197..248
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        249..>250
                     /gene="IGHG"
BASE COUNT           63 a           61 c           70 g           56 t
ORIGIN      
        1 atgggggtgg atgggatgtg ttgatcctgt aaatggtgaa ataatacacg cagacaactt
       61 ccagggcaga gtcaccatga ccgaagacac gtctatagac acagcctaca tggaactgag
      121 cagcctgaga tctgaggata cggccgtata ttactgtgcg acccacggag gctatagtga
      181 catctggaac tccctgtact acggtttgga ttcctggggc caaggggtct tcgtcaccgt
      241 ctcctcagcc
//
LOCUS       KCXD01004755             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:8247:7379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004755
VERSION     KCXD01004755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:8247:7379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63237.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       441..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          116 a          110 c          160 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttattat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa gtaagaaata ctacggagac tctgtgaagg accgattcag catcgccaga
      361 gacaattcca agaacaggct atatcttcaa atgaacaacc tgaaaatgga ggacacggca
      421 gtgtattact gtgcgagaga tgatagtggg gtgatcatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01004756             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12749:11738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004756
VERSION     KCXD01004756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12749:11738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..438
     V_segment       78..371
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63238.1"
                     /translation="CARVRGVNIHYFDYW"
     J_segment       391..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           76 a          141 c          131 g           92 t
ORIGIN      
        1 acatggggct gtgcaagaac atgaagcgcc tgtggttctt cctcctcctg gtggcagctc
       61 ccagatgggt cctgtcccag gtgcagctgc aggagtcggg cccaggactg gtgaagcctt
      121 cggagaccct gtccctcacc tgcgctgtct ctggtggctc cttcagcggt tactcctgga
      181 gctggatccg ccagccccca ggcaagggtc tggagtggat tggacatgtc agtggtagta
      241 gtgggagcac cgactaccac ccctccctca agagtcgagt caccgtttca acagacacgt
      301 ccaagcgcca gttctccctg aggctgatct ctgtgaccgc cgcggacacg gccgtctatc
      361 actgtgcgag agtccggggc gttaacatcc actactttga ctactggggc cagggagccc
      421 tggtcaccgt cgcctcagcc
//
LOCUS       KCXD01004757             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:23892:14653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004757
VERSION     KCXD01004757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:23892:14653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63239.1"
                     /translation="CARDVYGTGLDYW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          112 c          160 g          120 t
ORIGIN      
        1 acatggggag gtctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg tagcctctgg attcagtttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatctcgt
      301 ctgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaatgccaa gaacatgcta tgtgttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtctatggca cgggacttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004758             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13746:6155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004758
VERSION     KCXD01004758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13746:6155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63240.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          118 c          154 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggact gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cggcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcg gttatatcga
      301 atgatgaaag taacaaatac tacgcagact ctgtgaaggg ccgattcagc atctccagag
      361 acaattcgaa gaacatgcta tatcttcaca tgaacaccct gaaattggac gacacggccg
      421 tgtattactg tgcgacagat gcatttggta gcgggattga ccactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004759             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13658:5999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004759
VERSION     KCXD01004759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13658:5999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63241.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       445..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          103 a          122 c          161 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg acttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc tgcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcgg gtattgacag
      301 tggtgggggt accacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccgag aacacactgt atcttcaaat ggacagcctg acagctgagg acacggctgt
      421 ctattactgt gcgagagtcg tgggtggtag tgctggatac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004760             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13100:5493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004760
VERSION     KCXD01004760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13100:5493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63242.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       405..419
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          137 c          127 g          110 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg
      181 tgactctatc agcagtagtc actggtggag ctggatccgc cagcccccag ggaaaggcct
      241 ggagtggatt ggctatatca gtggtagtgg tgataacacc tactacaacc cctccctcaa
      301 gaatcgagtc accttttcaa cagtcacgtc caagaaccag ttctccctta agctgagctc
      361 tgtgaccgcc gcggacacgg ccatgtatta ctgttcgagg gtgcgtggat acaactacat
      421 tttatttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004761             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13175:10689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004761
VERSION     KCXD01004761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13175:10689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63243.1"
                     /translation="CARELYNSGWADAFDFW"
     D_segment       444..459
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..511
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          110 a          109 c          170 g          124 t
ORIGIN      
        1 acatggggga ggtctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcatctt cagtagttat
      241 ggcatgcatt gggtccgcca ggctccaggg aaggggctgg agtgggtggc aggtgtgtcg
      301 tatgatggga gtgagagtga ctacgcagac tctgtgaagg accgaatcac catttccaga
      361 gacaattcca agaacatggt atatgttcaa atgaacagcc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga gctgtataac agcggctggg ctgatgcctt tgatttctgg
      481 ggccaagggc tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01004762             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10844:8068
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004762
VERSION     KCXD01004762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10844:8068"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63244.1"
                     /translation="CAREGISASGVDYW"
     D_segment       398..404
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           81 a          134 c          147 g           99 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcaa cttcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc cccagggaag gggctggagt
      241 ggattgggtt tttcggtggt cgcaatggga acacgtacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaccagac acgtccaaag agcagttctc cctgaggctg aggtctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagggaggg gatatcagcg tcgggggtcg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004763             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9648:3995
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004763
VERSION     KCXD01004763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9648:3995"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..489
     V_segment       120..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63245.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       415..421
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          137 c          141 g           99 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccacct ggtgcagtct ggggctgaag tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaagt ttccggatac accttcaccg atttatccat gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaggtg ttgatactgt atctgatgga gtgatatacg
      301 cagaaaactt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgttta ttattgtgcg agaggtgtga
      421 cagcagacgt cttcggtttc ctcgggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004764             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20118:7747
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004764
VERSION     KCXD01004764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20118:7747"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63246.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       433..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          105 a          124 c          158 g          115 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcaggt ggtggagtct gggggcggct tggcaaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcagta cctatgctat
      241 gcactgggtc cgccaggctc caggaaaggg gctggagtgg gtctcagcca ttagtgttgg
      301 tggtagtaca tactacgcag actccgtgag gggccgattc accatctcca gagacaactc
      361 agagaacacg ctctccctgc aaatgaacag cctgagagct gaggacacgg ccgtgtatta
      421 ctgtgcgaaa ggggatacag ctacagttta ttacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004765             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18166:11886
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004765
VERSION     KCXD01004765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18166:11886"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..447
     V_segment       102..388
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63247.1"
                     /translation="CASSDYGWFDVW"
     D_segment       393..401
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..447
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           92 a          123 c          128 g          106 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggaat
      121 cggacccagg agtagtgaag ccttcggaga ccctgtccct cacctgcgtt gtctctggtg
      181 gcgatagtta taggtggagc tggatccgcc agcccccagg gaagggactg gaatggattg
      241 ggtatattta tggtagtatt acggacacca actacaaccc ctccctcaaa agtcgagtca
      301 ccatttcaaa agacacgtcc aagaagcagt tctccttgaa actgagctct gtgaccgtcg
      361 cggacacggc cgtgtatttc tgtgcgagtt cagactacgg ttggttcgat gtctggggcc
      421 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004766             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15072:9931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004766
VERSION     KCXD01004766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15072:9931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63248.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          119 c          146 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcat cttcagtaac tatgccatgc
      241 actgggtccg ccaggctcca gggaaggggc tagagtgggt ggcagttatt tcgcatgatg
      301 gaactaagaa atactacaca gactctgcga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat acaatatctt cacatgaaca gcctgaaatt ggaggacacg gccatatact
      421 actgtgcggc ctcctacttg gggtacggtt ttgagtactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004767             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13867:17346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004767
VERSION     KCXD01004767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13867:17346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63249.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          150 g          125 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg ctactggtgg agtctggagg aggcttggtt
      181 cagccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcttccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 aatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga
      361 gacaattcca tgaacatgct ttttcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004768             291 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14974:12738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004768
VERSION     KCXD01004768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 291)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14974:12738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..289
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..289
     V_segment       8..228
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <220..>258
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63250.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       235..247
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       248..289
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        290..>291
                     /gene="IGHG"
BASE COUNT           73 a           64 c           84 g           70 t
ORIGIN      
        1 acatgggctg gattcacctt cagtagtaat ggcatgcact gggtccgcca ggttccaggg
       61 aaggggctgg agtgggtggc agttatatcg tatgatgtaa gtaagaaata ctacgcagac
      121 tctgtgaagg accgattcac catctccaga gacaattcca agaacatgct atatcttcaa
      181 atgaacaacc tgaaattgga ggacacggcc gtgttctact gtgtgagaga ctcttatggg
      241 agtggtttgg atgcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004769             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17186:3426
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004769
VERSION     KCXD01004769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17186:3426"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63251.1"
                     /translation="CAIGPIGRWNGWSFDIW"
     D_segment       416..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          109 a          145 c          139 g           89 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccc tcaccgaagt gtccactcac tgggtgcgac
      241 aggcccccgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 aggtccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc tacatggaac
      361 tgagcagcct aagatctgag gacacggccg tgtattactg tgcgattggc cctatcggca
      421 ggtggaacgg ctggtccttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01004770             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20211:16212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004770
VERSION     KCXD01004770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20211:16212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63252.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       296..307
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           84 a           79 c          105 g           82 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
       61 cagcttctgg attcaccttc agtagttatg gcatgcactg ggtccgcctg gctccaggga
      121 aggggctgga gtgggtggca gttacatcgt ctgatgaaag taagaaatac tacggagact
      181 ctgtgaagga ccgattcacc atctccagag acaattccaa gaacatacta tatcttcaaa
      241 tgaacaacct gaaattgaag gacacggccg tgtactactg tgggagagat gataatgggg
      301 tgattatcga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004771             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14277:3844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004771
VERSION     KCXD01004771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14277:3844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    97..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        97..448
     V_segment       97..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63253.1"
                     /translation="CASNSITSGPDYW"
     D_segment       392..398
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           86 a          139 c          128 g           97 t
ORIGIN      
        1 acatggggga gaggcacgga catcctgtgc aagaacatga ggcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccgcctgc agctgcaggc ggcgggccca
      121 ggactggtga agccttcgga gaccctgtct ctcacctgcg ctgtctctgg tggctctatc
      181 agcggtaact actggagctg gatccgccgg gccccaggga agggactgga gtggattgga
      241 tatatctacg gtagtgattt taccaccaac tacaacccct ccctcaagag tcgagtcacc
      301 ctgtcagcag atacgtccaa gaaccagctc tccctgaacc tggcctctgt gaccgccgcg
      361 gacacggccg tctatttctg tgccagtaat agtataacat ctggtccaga ttactggggc
      421 cggggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004772             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:4494:5652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004772
VERSION     KCXD01004772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:4494:5652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63254.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          105 a          126 c          158 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctgaga ctctcctgcg cagtctctgg attcagtttc agtcactact
      241 tcatgagctg ggtccgccag actccaggga agggactgga gtggatctca gtgattaaca
      301 gtggtggaga taccacacac tatgcagact ccgtgaaggg cagattcacc atgtccagag
      361 agaacgccag gaacacactg tctcttcaaa tggacggcct gagacctgag gactcggctg
      421 tctattactg tgcgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004773             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19002:14886
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004773
VERSION     KCXD01004773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19002:14886"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63255.1"
                     /translation="CARRPENSYYFYCFDYW"
     D_segment       413..420
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          102 a          137 c          128 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgaagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctatcagc ggtgtttatg actggagctg gatccgccag tccccaggga aggggctaga
      241 gtggattgga tatgtccatg gaaatactgg gaacaccgac tacaatccgt ccctcaagaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgacac tgaggtctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagacgc ccagaaaata gttactactt
      421 ctactgcttt gactactggg gccacggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004774             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16388:18381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004774
VERSION     KCXD01004774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16388:18381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63256.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       412..417
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           85 a          140 c          141 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcgggagtc
      121 gggcccagca gtagtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gccccaggga agggactgca
      241 gtggattggt tttatctatg gtactggtgg tagcacctac tacactccct ccctcaagag
      301 tcgactcacc atttcagcgg acacgtccaa gaaccagttc tccctgcatc tgacctctgt
      361 aaccgccgcg gacacggccg tatattactg tgcgagagtt tcgggcaggt gggaactttt
      421 tgagcctggg tcagaggact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004775             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20982:3332
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004775
VERSION     KCXD01004775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20982:3332"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..439
     V_segment       85..380
                     /gene="IGHV2-173"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63257.1"
                     /translation="CARRLWGRFDSW"
     D_segment       387..393
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           94 a          134 c          111 g          102 t
ORIGIN      
        1 acatgggggt gactcctgtg ccccaccatg gacacgcttt gctccacgct cctgctgctg
       61 accgtcccgt cctgggtctt gtcccaggtg accttgaagg agtctggtcc tacgctggtg
      121 aaacccacac agaccctcac gctgacctgt accttctctg ggttctcaat cagttctact
      181 gatacgggtg tgagctggat ccgtcagccc ccagggaagg ccctggaatg gcttgcaacc
      241 gtttattggg ataatgataa gttcttcggc acatctctga agaacagact caccatctcc
      301 aaggacacct ccaaaaacca ggtggttctc acaatgacca acatggaccc tgtggacaca
      361 gccacatatt actgtgcacg acgactctgg ggaaggtttg actcctgggg ccagggagtc
      421 ctggtcaatg tctcctcagc c
//
LOCUS       KCXD01004776             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:7152:4365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004776
VERSION     KCXD01004776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:7152:4365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..499
     V_segment       142..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63258.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       445..450
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          105 a          119 c          159 g          118 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagcct tggaagtcca cagtgttcca ttcggtgatc
       61 agcactgaac acagaggact caccatggag tctgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcacag
      181 cctggggggt ccctgagact ctcctgttca gcctctggat tcaccttcag tagacactgg
      241 atgaactggg tccgccaggc tccaggaaag gggctagagt gggtctccgg tattaatagt
      301 ggtggggata ctacatacta cgcagactcc gtgaagggcc gattcaccat gtccagagac
      361 aactcaaaga acactctctc cctgcaaatg aacagcctga gagcggagga cacggccgtg
      421 tattattgtg tccaagggga aatttttgga gtgggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01004777             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:9332:9780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004777
VERSION     KCXD01004777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:9332:9780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63259.1"
                     /translation="CASPLLPATGNW"
     D_segment       413..420
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           87 a          131 c          133 g          107 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgtgat gtctctggtc
      181 attccatcaa tagtggttac tcctggggct ggatccgtca gcccccaggg aagggactgg
      241 agtggattgg gtttatcggt ggtcgtagtg ggtacaccta ctacaacccc tccctcagga
      301 gtcgagtcag tatctcaaaa gacacgtcca agaaccagtt ctccctggaa gtgagttctc
      361 tgagcgccgc ggacacggcc gtgtattatt gtgcgagtcc tctccttccg gcaactggaa
      421 actggggcca gggagtcctg gtcatcgtct cctcagcc
//
LOCUS       KCXD01004778             316 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11978:13035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004778
VERSION     KCXD01004778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 316)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 316)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11978:13035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..314
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..314
     V_segment       8..238
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <230..>283
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63260.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       239..245
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       273..314
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        315..>316
                     /gene="IGHG"
BASE COUNT           73 a           77 c           96 g           70 t
ORIGIN      
        1 acatgggtgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
       61 ggcccctgga aaagggcttg agtggatggg aggtgttgat actgtatctg atggagtgat
      121 atacgcagaa aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      181 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattatt gtgcgagagg
      241 ggtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      301 caccgtctcc tcagcc
//
LOCUS       KCXD01004779             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24647:12509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004779
VERSION     KCXD01004779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24647:12509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63261.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          114 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004780             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13253:2873
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004780
VERSION     KCXD01004780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13253:2873"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..220
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <215..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63262.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       229..236
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       253..296
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           68 a           88 c           82 g           60 t
ORIGIN      
        1 tcatgggaag gtctccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
       61 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      121 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      181 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg gttggcccta gcggcacttg
      241 gaaccactgg cccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01004781             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7266:14019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004781
VERSION     KCXD01004781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7266:14019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63263.1"
                     /translation="CARDAYGRGFDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          114 c          152 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcccgggggg tccctgagac tctcctgtgc agcctctgga tacaccttca gtaattttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcag ttatatcgta
      301 tgatgaagat aagaattacc acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acacggcctt
      421 ctattattgt gcgagagatg cttacggtag ggggtttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004782             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19844:12685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004782
VERSION     KCXD01004782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19844:12685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    54..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        54..444
     V_segment       54..347
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <339..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63264.1"
                     /translation="CARDAGYGDAISVVDINMFPHFDFW"
     D_segment       367..388
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT           86 a          125 c          127 g          108 t
ORIGIN      
        1 acatggggtg gttcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc
       61 agctgcagga gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgtg
      121 ctgtctctgg ttcctccatc agtagttact ggtggacctg gatccgccag cccccaggga
      181 agggactgga gtggattggg gagatcaatg gtaatagtgg aagtttttac tccaaccctt
      241 ccctcaacag tcgagtcacc atttcaaaag acgcgtccaa gaaccagttc tccctgaatc
      301 tgagctctgt gaccgccgcg gacacggccg tatattactg tgcgagagat gccgggtatg
      361 gggatgcgat atcagtagtc gatattaata tgttccccca ctttgacttc tggggccagg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004783             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8432:7467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004783
VERSION     KCXD01004783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8432:7467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..480
     V_segment       114..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63265.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       419..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          138 c          135 g           98 t
ORIGIN      
        1 acatggggac agccacatcc ctcccctaca gaagccccag agcacagcac ctcaccatgg
       61 actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc tctgaggtcc
      121 agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag gtctcctgcg
      181 aggtttccgg atataccttc accgaactgt ccattcattg ggtgcgacag gcccctggaa
      241 aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata aacgcagaaa
      301 aattccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc tacatggacc
      361 tgatcagtct gagatctgaa gacacggccg tgtattactg tgcgacatca cccagcggca
      421 cctggctata ttggtacttc gatttctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01004784             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9727:6379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004784
VERSION     KCXD01004784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9727:6379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..480
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63266.1"
                     /translation="CARGRIHLQFMDSW"
     D_segment       429..436
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          113 a          134 c          137 g           98 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagcgca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgtaa ggcttctgga tacaccttca acatgtttgc catcaattgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag ggaacatccc tcttgttgat ataacaaagt
      301 acgcacagaa gttccaggac agagtcacat ttaccgcgga cacgtccact agcacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gcgagaggga
      421 ggattcacct acagttcatg gactcctggg gccagggagt cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01004785             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19716:18969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004785
VERSION     KCXD01004785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19716:18969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    11..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        11..321
     V_segment       11..260
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63267.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       271..279
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           77 a           76 c           92 g           78 t
ORIGIN      
        1 acatggggga ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtttct
       61 atggcataca ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt
      121 cgaatgatga aactaagaaa tactacgcag actctgtgaa ggaccgattc accatttcca
      181 gagacaattc caagaacatg ctatttcttc aaatggacaa cctgaaattg gaggacacgg
      241 ccgtctatta ttgtgtgaga gatgatttag gcagcggctt agggtcctgg ggccagggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01004786             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14317:3709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004786
VERSION     KCXD01004786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14317:3709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63268.1"
                     /translation="CARGGFGSSVWSNLVYGFNSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          139 c          149 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgacc ctgcaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 gggttcggta gcagtgtctg gtccaatctc gtctatggtt ttaattcctg gggccaaggg
      481 atcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004787             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18001:18281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004787
VERSION     KCXD01004787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18001:18281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..504
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63269.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       450..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>508
                     /gene="IGHG"
BASE COUNT          103 a          128 c          157 g          120 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgc aactggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagga acactggtca
      301 aatcgtatac tacgctgact ccgtgaaggg ccgattcacc atctccagag acaacgccaa
      361 gaactcgctg tctctgcgaa tgagcagtct gagagccgag gacacggccg tgtattactg
      421 tactagaatt ggcgtcggat ctctggcaac ggctggtgac tactttgacc actggggcca
      481 gggagtcctg gtcaccgtct cctccgcc
//
LOCUS       KCXD01004788             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:23706:9490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004788
VERSION     KCXD01004788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:23706:9490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..501
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63270.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       436..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          139 c          149 g          100 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggcttct ggatacacct tcagcatcta tgtcatcaat tgggtgcgcc
      241 aggcccctgg acaagggcta gagtggatgg gaggaatcat ccctcttgtt ggtacaacaa
      301 actacgcaca gaagttccag ggcagagtca cgattattac ggacacgtcc acaagcacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgagag
      421 gcccccctac tgaagggggt gattattctg ggggggcttt gagccgatgg ggccagggag
      481 tccaggtcac cgtctcctca gcc
//
LOCUS       KCXD01004789             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8192:18718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004789
VERSION     KCXD01004789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8192:18718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..493
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63271.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          111 a          119 c          153 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgca
      301 tgatgaaact aggaaatact acgcagactc tgttagggac cgattcaccg tctccagaga
      361 caattccaac aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt acgagagacg catttggcag cggctgtgac tactggggcc tgggagtcct
      481 ggtcaccgtc tccccagcc
//
LOCUS       KCXD01004790             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18702:17487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004790
VERSION     KCXD01004790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18702:17487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63272.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          134 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga gaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccatg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagtc tgagatctga ggacacggcc gtatattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004791             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12104:12038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004791
VERSION     KCXD01004791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12104:12038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63273.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       403..410
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          137 c          128 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 ggccccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agttcctact ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctatggta gtactgggag caccggctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtcaaagaa ccagttctcc ctgaagctga gttctgtgac
      361 cgccgcggac accgccgtct attactgtgc gagatatgga gatgatagtg ttcattacaa
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004792             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14731:20710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004792
VERSION     KCXD01004792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14731:20710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63274.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          115 c          157 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggtttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga ttgggtggca gttgaatcgt
      301 ttgatggagg taagaaatac tacgctgact ctgtgaatga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004793             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19901:11136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004793
VERSION     KCXD01004793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19901:11136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63275.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          113 c          156 g          118 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agtctctgga ttcaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tgacatcgta
      301 tgatggaagt tggaagtact acggagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagggg aatacagtaa ctctgttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004794             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16354:9171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004794
VERSION     KCXD01004794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16354:9171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63276.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          121 c          144 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgcag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggaatcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004795             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:4882:12951
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004795
VERSION     KCXD01004795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:4882:12951"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63277.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       418..425
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          137 c          151 g          106 t
ORIGIN      
        1 acatggggga taacaaccac gtccctcctc tatagaagcc cctgggaaca cagctcatca
       61 ccatggactt gacctggagg ctcctctttg tggtggcagc agctacaggt gcccagtccc
      121 aggtccagct ggtgcagtcc ggggctgagg tgaagaagcc tggggcctca gtgaagctct
      181 cctgcaaggc ttctggatac acgttcagca tctatgccat cagttgggtg cgacaggccc
      241 ctggacaagg gcttgagtgg atgggaggga tcatccctct tgttgatata acaaactacg
      301 cacagaggtt ccagggcaga gtcacgattt ccgcggacac gtccacaagc acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg aggggagatt
      421 gtactgatac tgactgctct tccgcggggg gcgcctttga tttctggggc caagggctca
      481 gggtcaccgt ctcttcagcc
//
LOCUS       KCXD01004796             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21271:4389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004796
VERSION     KCXD01004796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21271:4389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63278.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          137 c          143 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa tccctactac cacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga ccagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004797             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15143:9237
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004797
VERSION     KCXD01004797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15143:9237"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63279.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          128 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtcttaacgc
      301 tggtggggat accacctact atgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004798             287 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11889:2025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004798
VERSION     KCXD01004798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11889:2025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..285
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..285
     V_segment       7..208
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <201..>254
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63280.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       220..227
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       243..285
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        286..>287
                     /gene="IGHG"
BASE COUNT           72 a           64 c           80 g           71 t
ORIGIN      
        1 acatgggtag ctatgacatg cactgggttc gccaggctcc agggaagggt ctggagtggg
       61 tatcaggtat taacattggc ggtgacacat actacccaga ctctgtgaag ggtcgattca
      121 ctatctccag agacaatgcc aagaactccg tgtatcttca aatgaacagc ctgagagttg
      181 aggacactgc tgtgtatttt tgtgcaaggg ggatagataa ctaccacttt agtaatacgg
      241 agtttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004799             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:25797:15889
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004799
VERSION     KCXD01004799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:25797:15889"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63281.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       401..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          137 c          139 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctacaggag
      121 tcgggcccag gactggtgaa gcctctggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatga gcagtcacta ctgcagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac ggatctctgg tagtggtggg agcaccgact acaacccctc cctcaggagt
      301 cgagtcacca tctcaacaga cacgtccaag aaggagatct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagagaag actatggtgg taattattac
      421 tttaaccggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004800             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13274:18157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004800
VERSION     KCXD01004800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13274:18157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63282.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..445
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          122 c          147 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgctgctatt
      121 ttaagaggtg tccagtgtga ggtccacctg gtggaatctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttc ctttggcatg
      241 cactgggtcc gccaggcacc ggggaagggg ctggagtggg tggcagtttt atcgtctgat
      301 ggaactaaca aatactacgc agactctttg aaagaccgat tcaccatatc cagagacaac
      361 tccaagaaca tactatatct tcaactgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga gagatgtgta tggctcgggg cttgactact ggggccaggg agtcccgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004801             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10163:11033
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004801
VERSION     KCXD01004801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10163:11033"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63283.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       426..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          105 a          138 c          145 g          101 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcgtcc ctcttgttgg aacaacaaac
      301 tccgcacaga agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagtc
      361 tacatggagt tgagcagcct gagatctgag gacacggcca tgtattactg tgcgagaggc
      421 ctgggtagca gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01004802             335 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:5832:7502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004802
VERSION     KCXD01004802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 335)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 335)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:5832:7502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..333
     V_segment       8..245
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <237..>302
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63284.1"
                     /translation="CAKVDHEDDYGFYYTWSYFDSW"
     D_segment       253..280
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       288..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>335
                     /gene="IGHG"
BASE COUNT           76 a           89 c           92 g           78 t
ORIGIN      
        1 acatggggag acttacctgt gcagcctctg gattcacctt cagtaggtat gccatgcact
       61 gggtccgcca ggctccagac aaggggctgg agtgggtctc agttattagt agtggtggta
      121 gcacatacta cgcagactcc gtgaagggcc gattcaccat ctccagagac aactcaaaga
      181 ccacgctctc cctgcaaatg aacagcctga gacctgggga cacggccgtg tattactgtg
      241 cgaaagttga tcacgaggat gattacggtt tctattacac ttggagttac tttgactcct
      301 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004803             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6786:13977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004803
VERSION     KCXD01004803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6786:13977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63285.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       417..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          101 a          143 c          126 g          106 t
ORIGIN      
        1 acatggggtc tccctcaccg cacagctggg atctcagttc ttcatttctg tcctccacca
       61 cgatggggtc aactgccatc ctcgccctcc tcctggctgt tctccaagga gtctgtgccg
      121 aggtgaaact ggtgcagtct ggggcagagg tgagaaggcc cggggagtct ctgaagatct
      181 cctgtaagac ttctggatac agctttacca ccaactggat cagttgggtg cgccagacgc
      241 ccggaaaagg cctggaatgg atggggacca tctatcctgc tgattctgag gccaaataca
      301 acccgtcctt ccaaggccac gtcactatct cagccgacaa gtccatcagt accacctacc
      361 tgcagtggag cagcctgaag gcctcggaca ccgccacgta tttctgtgcg aaaacctact
      421 atagtggtag tttggaaatc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004804             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12610:11404
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004804
VERSION     KCXD01004804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12610:11404"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63286.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          116 c          161 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcacagcctg
      181 gggggtccct gagactctcc tgttcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctccggtatt aatagtggtg
      301 gggatactac atactacgca gactccgtga agggccgatt caccatgtcc agagacaatt
      361 caaagaacac tctctccctg caaatgaaca gcctgagagc ggaggacacg gccgtgtatt
      421 attgtgtgca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004805             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17277:12468
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004805
VERSION     KCXD01004805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17277:12468"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63287.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..492
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          113 c          149 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt cttactattt
      121 taagaggtgt cgagtgtgag gtgcatctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gacactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccgggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaagtaagaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ctaagaacac gctatatctt cagatgaaca acctgcaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgataat ggggtgctta tcgacttctg gggccgggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004806             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22014:11572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004806
VERSION     KCXD01004806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22014:11572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    22..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        22..373
     V_segment       22..318
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <310..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63288.1"
                     /translation="CARWGTPFDYW"
     D_segment       319..323
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       330..373
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           75 a          111 c          110 g           79 t
ORIGIN      
        1 acatggggat gggtcttgtc ccaggtgcag ctgcaggagt cgggcccagg actggtgaag
       61 ccttcggaga ccctgtccct cacctgcgct gtctctggta gctccatcaa cagtggttat
      121 gcctggagct ggatccgcca gcccccaggg aaggggctgg agtggattgg gcatatctat
      181 gatagtagtg ggaacaccta ctacaacccc tccctcaaga gtcgagtcac catttcaaaa
      241 gacacgtcca agaaccagtt ctccctgaac ctgagttctg tgaccgccgc ggacacggcc
      301 gtgtattact gtgcgagatg ggggaccccc tttgactact ggggccaggg agtcctggtc
      361 accgtctcct cagcc
//
LOCUS       KCXD01004807             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20336:6789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004807
VERSION     KCXD01004807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20336:6789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63289.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          106 a          124 c          157 g          120 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gtctctggat tcagtttcag tcactacttc
      241 atgagctggg tccgccaggc tccagggaag ggactggagt ggatctcagg gattaacagt
      301 ggtggagata ccacacacta tgcagactcc gtgaagggca gattcaccat gtccagagag
      361 aacgccaaga acacactgtc ccttcaaatg gacggcctga gagctgaaga ctcggctgtc
      421 tattattgtg cgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004808             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21577:4791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004808
VERSION     KCXD01004808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21577:4791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63290.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          146 c          133 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaagtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca ggatttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctgtatgg taaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta cttggaactg
      361 agcggcctga cttctgagga cacggccgtg tattactgtg cgactggccc taccggcacc
      421 tggaacgcct ggtacctcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01004809             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24982:5596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004809
VERSION     KCXD01004809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24982:5596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63291.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       432..436
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          121 c          159 g          114 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaatatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcaa cttcaattac tactacatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt aacagtggtg
      301 gggatagcac atactatgcg gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag agtggtgggt ggtgccgcag gatacttcga cttctggggc cagggcgccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004810             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:15959:13705
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004810
VERSION     KCXD01004810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:15959:13705"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63292.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       425..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          144 c          136 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactgtacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 attctgaggt ccagctggtg caatctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctttatat ggtgaaatga
      301 tacacacaga acagttccag ggcagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgagtg
      421 gccctagcgg cagctggaac gactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004811             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11522:12290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004811
VERSION     KCXD01004811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11522:12290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..434
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..434
     V_segment       71..367
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63293.1"
                     /translation="CARWGDSQSIYYFDYW"
     D_segment       368..375
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..434
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        435..>439
                     /gene="IGHG"
BASE COUNT           87 a          124 c          126 g          102 t
ORIGIN      
        1 acatgggaag aacatgaagc acctgtggtt cttcctcctc ctggtggcag ctcccagatg
       61 ggtcctgtcc caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac
      121 cctgtccctc acatgcgctg tctctggtgg ctctattagc agtagtaact ggtggaactg
      181 gatccgccag cccccaggga aagggctgga gtggattggg tatatcagtg gtgctagtgg
      241 tagtaccgac tatcacccct ccctcaagag tcgagtcacc atttcaacag acacgtccaa
      301 gaaccagttt accctgaagt tgagctctgt gaccgccgcg gacacggccg tgtattactg
      361 tgcgagatgg ggtgactccc agtccattta ctactttgac tactggggcc agggagtcct
      421 ggtctccgtc tccttagcc
//
LOCUS       KCXD01004812             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9337:3780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004812
VERSION     KCXD01004812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9337:3780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63294.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       442..450
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          113 c          157 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccacacg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct ggggctctcc tgtgcagcct ctggattcac cttcagtcac tatggcgttc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaaataagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaagaccat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgtcaga ggcggtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004813             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11475:6938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004813
VERSION     KCXD01004813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11475:6938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63295.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       434..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          115 a          108 c          158 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaagtaagaa atactacgga gactctgtga aggaccgatt cagcatcgcc agagacaatt
      361 ccaagaacag gctatatctt caaatgaaca acctgaaaat ggaggacacg gcagtgtatt
      421 actgtgcgag agatgatagt ggggtgatca tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01004814             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18527:2851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004814
VERSION     KCXD01004814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18527:2851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63296.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          111 c          146 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcaaca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtaag tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgca aactctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagaacat actttatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004815             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17070:5277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004815
VERSION     KCXD01004815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17070:5277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63297.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          141 c          148 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttcttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcga
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc aacacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattagta
      301 ctgctggtag cacatactac gcagactccg tgaagggccg cttcaccgtc tccagagaca
      361 actcaaagaa cacgctctcc ctccaagtga acagcctgag acctgaggac acggccgtgt
      421 attactgtgc gaaaggaggt agcagctctt tctactggta cttcgatatc cggggccctg
      481 gcaccccagt caccatctcc tcagcc
//
LOCUS       KCXD01004816             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:6565:13819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004816
VERSION     KCXD01004816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:6565:13819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63298.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          118 c          153 g          120 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtt tatcttcaga tgaacaacct gaagttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004817             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8828:8496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004817
VERSION     KCXD01004817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8828:8496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63299.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          112 c          156 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tccgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcatgttca gtaactatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatatcgta
      301 tgatgtaact gtgaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagggatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01004818             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:19144:4872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004818
VERSION     KCXD01004818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:19144:4872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..475
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63300.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       415..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>481
                     /gene="IGHG"
BASE COUNT           84 a          143 c          140 g          114 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agtaccaact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtgt atctttggtg gtggtatctt tggtagtgga agtaacacct tctacagccc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagacccagc tctccctgaa
      361 gctgacgtct gtgaccgccg cggacacggc cgtgtatttc tgtgcgagcg ctgatagtgg
      421 ttatcctccc tacttctttg acatctgggg ccagggagtc ctggtcaccg tctccccagc
      481 c
//
LOCUS       KCXD01004819             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7912:13104
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004819
VERSION     KCXD01004819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7912:13104"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63301.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          114 c          148 g          121 t
ORIGIN      
        1 acatgggagc tctgggagag gaacccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttattgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtagctatgg
      241 cttacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgtc
      301 tgatgaaagt aggaaatact acgcagactc tctgaaggac cgattcacca tttccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgagggatg ataatggggt gcttatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004820             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22468:4153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004820
VERSION     KCXD01004820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22468:4153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..324
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..324
     V_segment       8..263
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <255..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63302.1"
                     /translation="CARKWAGYGLDSW"
     J_segment       276..324
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        325..>326
                     /gene="IGHG"
BASE COUNT           68 a           94 c           91 g           73 t
ORIGIN      
        1 acatggggcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc tccctcagcg
       61 gttactactg gaattggatc cgccaaccac cagggaaggg gctggagtgg attggttata
      121 tcgctggtag tagtggaagt accgactaca acccctccct caagagtcga gtcaccattt
      181 caacagacac gtccaggaac cagttctccc tgaaactgac ctctgtgacc gccgcggaca
      241 cggccgtgta ttattgtgca agaaaatggg ccggatacgg tttggattcc tggggccaag
      301 gggtcgtcgt tacagtctcc tcagcc
//
LOCUS       KCXD01004821             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24944:20423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004821
VERSION     KCXD01004821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24944:20423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63303.1"
                     /translation="CAREGISASGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          134 c          147 g           99 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacgtact acaaccccgc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaaa gagcagttct ccctgaggct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc gtcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004822             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13570:15516
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004822
VERSION     KCXD01004822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13570:15516"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63304.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       447..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          110 c          155 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgaactgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcttctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcct ggctccaggg aaggggctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatact atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtactact gtgggagaga tgataatggg gtgattatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004823             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8872:6981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004823
VERSION     KCXD01004823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8872:6981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63305.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          117 a          117 c          148 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catgcactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01004824             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20593:6700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004824
VERSION     KCXD01004824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20593:6700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63306.1"
                     /translation="CARSGDYGYYYDFDYW"
     D_segment       400..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          138 c          132 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cctcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactcct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggacgt ttctataata gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagatcgggt gattacggtt actattacga
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004825             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16066:11762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004825
VERSION     KCXD01004825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16066:11762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63307.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          120 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccac tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg gttcaccttc agtggctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggcg gttatatcga
      301 gtgatggaac taacagatac tacgcagact ctctgaagga ccgattcagc atttccagag
      361 agaattccaa gaacgtgcta tatcttcaaa tgaaccacct gaaactggag gacacggccg
      421 tctattactg cgcgacagat gcttttggta gcgggattga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004826             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:20670:2659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004826
VERSION     KCXD01004826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:20670:2659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63308.1"
                     /translation="CVRDEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          137 c          130 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggccctgtcc caggtgcttc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aaccccgccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagagatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004827             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15555:9241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004827
VERSION     KCXD01004827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15555:9241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63309.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          124 c          151 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttaat ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gctcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcagttatta acgctggtgg
      301 ggataccacc tactatgcag actccgtgaa gggcagatcc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ttgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004828             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13971:17438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004828
VERSION     KCXD01004828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13971:17438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63310.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          116 a          147 c          127 g           91 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgacgtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagcaga
      301 ctacacacag aagttccaaa acagagtcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tcagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01004829             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21811:19900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004829
VERSION     KCXD01004829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21811:19900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..483
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63311.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>487
                     /gene="IGHG"
BASE COUNT          117 a          140 c          130 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggct acagcttcgc cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggtttgagt ggatgggagg ttttgctagt atatatggtc aaataataca
      301 tacagagaga ttccagggca gagtcaccat gacagcggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctccgcc
//
LOCUS       KCXD01004830             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7725:6674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004830
VERSION     KCXD01004830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7725:6674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63312.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          112 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatgcta tattttcaaa tgaacaacct gaaattggaa gacacggccg
      421 tatattactg tgcgagagat gtctatggca ggggacttga cttctggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004831             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14511:21704
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004831
VERSION     KCXD01004831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14511:21704"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63313.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          126 c          157 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac aaaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta
      241 catgagctgg gtccgccagc cgccagggaa gggtctggag tggatctcag gtattaacgc
      301 tggtggggat ggcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004832             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7944:18050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004832
VERSION     KCXD01004832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7944:18050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63314.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          113 c          155 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttcctatg
      241 gcatacactg ggtccgccag tctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaagtac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggaggcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004833             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19552:8003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004833
VERSION     KCXD01004833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19552:8003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63315.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       404..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           98 a          135 c          137 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tggctccttc agcggtttct attggagctg gatccgccag tccccaggga agggactgga
      241 gtggattggg tatatcagtg ctagtagtgg gagtaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa taaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag aaatactata gtggtagtta
      421 taaacacaac tggttcgatg tctggggccc gggagtccag gtcaccgtct cctcagcc
//
LOCUS       KCXD01004834             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12841:20622
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004834
VERSION     KCXD01004834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12841:20622"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63316.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       424..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          110 a          132 c          149 g          100 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctatg tcatcaattg ggtgcgacag gcccctggac
      241 aagggctaga gtggatggga gggatcatcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attattgcgg acacgtccac aagcacagcc tacatggaat
      361 tgagaagcct gagatctgag gacacggccg tgtattactg tgcgagaggc ccccctactg
      421 aagggggtga ttattctggg ggggctttga gtcgatgggg ccagggagtc caggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004835             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9572:16265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004835
VERSION     KCXD01004835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9572:16265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..432
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63317.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       443..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          111 a          118 c          154 g          124 t
ORIGIN      
        1 acatggggga ggagaggagc ccagccctgg gattcccagg tgttttcatt tgtgatcagc
       61 actgaacaca gaagactcat catggagttt ggcctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagggtga ggtgcaactg gtggagtctg ggggcggctt ggcaaagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca ccctcagtaa ctactggatg
      241 tactgggttc gccaggcacc agggaagggg ctggagtgga tctcagctat taatagtgtt
      301 ggtgatagca catactatgc agactccgtg aagggcagat tcaccatctc cagagagagc
      361 gccaagaaca cactatatct tcaaatggac agcctgagag ctgaggacac ggctgtctat
      421 tactgtgcga gagtaccggg cctagtggta tttactgctt cacttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004836             409 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:7201:7917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004836
VERSION     KCXD01004836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 409)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 409)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:7201:7917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    53..407
                     /note="immunoglobulin heavy chain variable region"
     V_region        53..407
     V_segment       53..346
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <338..>376
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63318.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       356..361
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..407
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        408..>409
                     /gene="IGHG"
BASE COUNT           90 a           93 c          123 g          103 t
ORIGIN      
        1 acatgggctg agctgggttt tccttgttgc tattttaaga gatgtccagt gtgaggtgca
       61 cctggtggaa tctggaggag gttcggttca gcctgggggg tccctgagac tctcctgtgc
      121 agcctctgga ttcaccttca gtacctttgg cattcactgg gtccgccagg ctccagggaa
      181 ggggctggag tgggtggcag ttatatcgta tgatgaaact aagacatact acgcagactc
      241 tgtgaaggac cgattcacca tctccagaga caattccaag aacatggtat atcttcaaat
      301 gaacaacctg aaattggagg acacggccgt gtattactgt gcgagagatg tcaggggaac
      361 ggggtttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004837             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17762:13176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004837
VERSION     KCXD01004837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17762:13176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63319.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       444..448
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          111 a          139 c          145 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggttttcg gatacacctt cagcgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac actgtctctg acggagtgat
      301 atacgcagag aacttccagg gcagagtcgc catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ttgagcagcc tgagatctga ggacacggcc gtttattact gtgcgagagg
      421 tttatcacca gacgtcttcg gtttcctcgg gcttggctac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004838             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20169:3968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004838
VERSION     KCXD01004838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20169:3968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63320.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       434..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          107 a          116 c          151 g          121 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgtttctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggagtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgtctgtaat ttcgtctgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaac
      361 tccaagaaca tactatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttctgtgtga gagatgcctt cgggggcggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004839             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12361:4648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004839
VERSION     KCXD01004839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12361:4648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63321.1"
                     /translation="CAKGGWLGDYPPSDWFDVW"
     D_segment       428..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..495
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT           97 a          148 c          141 g          111 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgct gctggtgcag tctggagcag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga gacaccttaa cctactattg gatcagctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatggggg cgattgatcc tggtgattct aataccaaat
      301 acagcccgtc cttccaaggc caggtcacca tctcagccga caagtccatc agcaccgcct
      361 acctgcagtg gaccagcctg aaggcctcgg acaccgccac ctattattgt gcgaaagggg
      421 ggtggttggg tgattatcca ccctcagact ggttcgatgt ctggggcccg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004840             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18151:16957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004840
VERSION     KCXD01004840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18151:16957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63322.1"
                     /translation="CARGYCHGTYCSSGLVSW"
     D_segment       430..445
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          142 c          137 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtgac agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaggag gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc cgtgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggag gtgttcatcc tctatatgat aaaataacac
      301 acgcagagaa cttccaggac agagtcatca tgaccgagga cacgtcgaca gacacagcct
      361 acatggaact gagcagcctg acatctgagg acacggccgt ctattactgt gcgagaggat
      421 attgtcatgg tacttattgc tcctcgggtc ttgtctcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004841             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:4886:8376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004841
VERSION     KCXD01004841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:4886:8376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..478
     V_segment       118..409
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63323.1"
                     /translation="CATGFGGSWTRFDYW"
     D_segment       426..431
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           95 a          136 c          140 g          109 t
ORIGIN      
        1 acatgggaac gcagagtaca tgggggttct ctgagagtca cggacatcct gtgcaagaac
       61 atgaagcacc tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag
      121 ctgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtctgtcacc
      181 tgcgctgtct ctggtggctc tatcagtagt aactactgga gttggatccg ccaggcccca
      241 gggaagggac tggaatggat tggatatatc tttggtagtg gcagtgacac caactacaac
      301 ccctccctca agagtcgagt caccctgtca gtagacacgt ccaacaatca gctctccctg
      361 gagctgagct ctgtgaccgc cgcggacacg gccctttatt attgtgcgac cgggtttggt
      421 ggcagttgga ccagatttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004842             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10782:5617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004842
VERSION     KCXD01004842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10782:5617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..488
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63324.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>494
                     /gene="IGHG"
BASE COUNT          109 a          115 c          156 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgaa gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtggc tctggcatgc
      241 actgggtccg ccagtctcca gggaaggggc tggaatgggt ggcggttata tcgaatgatg
      301 gaactaagaa atactacgcg gactctgtga aggaccgatt cagcatttcc agagacaact
      361 ccaagaacat gctgtatctt caaatgaaca acctgaaagt ggaggacacg gccgtctact
      421 tctgtgcgac agatgcgttt ggtagcggga ttgactactg gggccgggga gtcctggtca
      481 ccgtctccac agcc
//
LOCUS       KCXD01004843             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26228:9481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004843
VERSION     KCXD01004843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26228:9481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63325.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       454..461
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          102 a          133 c          157 g          125 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgacc tgggttttcc ttgctgcttt
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggggcct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attgtggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagtaagac
      301 tggtgaaacc gaatactaca ctgactccgt gaagggccga ttcaccatct ccagaaacaa
      361 cgccgagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgcact agaatttgtt gtccccgtga ttttagcagc gactgtcact ggttcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004844             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18630:15365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004844
VERSION     KCXD01004844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18630:15365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    60..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        60..438
     V_segment       60..352
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <351..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63326.1"
                     /translation="CTAEITVEIVATPRSYDYW"
     D_segment       365..390
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT          102 a          105 c          125 g          108 t
ORIGIN      
        1 acatggggtt tgtactgagc tgggttttcc ttgttgctat attaaaaggt gtccagtgtg
       61 aggtgcagct ggtggagtct gggggagact tagtccagcc tggcgggtcc ctgagactct
      121 cctgtgcagc ctctggattc accttcagtg actatgccat gggctgggtc cgccaggctt
      181 ctgggaaagg actggagtgg gttggctata ttagaagcaa ctataaccat tacgcgacag
      241 aatacgccgc atcggtgaaa ggcagattca ccatctccag agatgattca aagaacacgc
      301 tatatttgca aatgagcagc ctgaaaaccg aggacacggc cgtgtattac tgcaccgcag
      361 aaatcactgt agagatagtg gctactcctc gttcttatga ctactggggc cagggagtcc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004845             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19729:12960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004845
VERSION     KCXD01004845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19729:12960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..449
     V_segment       101..391
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63327.1"
                     /translation="CTRQQSNHDVW"
     D_segment       401..406
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..449
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           91 a          138 c          125 g           97 t
ORIGIN      
        1 acatgggggt tctctgacag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca ggggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagt ggttatggct ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgcaact atctatggta gtagtggtaa cacctactac aacccctccc tcaggagtcg
      301 agtcaccatt tctaaagaca cgtccaacaa ccacttctcc ctgaggctaa actctatgac
      361 cgccgcggac acggccgtgt attactgtac gcgccagcaa agtaaccacg atgtctgggg
      421 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004846             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6906:10751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004846
VERSION     KCXD01004846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6906:10751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63328.1"
                     /translation="CARGFCHGTYCSSGLVSW"
     D_segment       426..441
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          140 c          140 g           99 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 agtccagctg gtgcagtctg gggctgaagt gaggaggcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccgtg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaggtgt tcatcctcta tatggtaaaa taacacacgc
      301 agagaacttc caggacagag tcatcatgac cgaggacacg tcgacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtctat tactgtgcga gaggattttg
      421 tcatggtact tattgctcct cgggtcttgt ctcctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01004847             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23463:9202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004847
VERSION     KCXD01004847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23463:9202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63329.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          104 a          129 c          155 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatac
      241 actgggtccg ccaggctccc gggaaggggc tggagtgggt ctcagccatt agtagtggtg
      301 gtagcacata ctacgcagac tccatgaagg gccgagccac catctccaga gacaactcaa
      361 agaacacggt ctccctgcaa gtgaacagcc tgacttctga ggacacggcc gtgttttact
      421 gtgcgagagg ggagacagct tcagtttact acgctttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004848             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14019:21182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004848
VERSION     KCXD01004848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14019:21182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63330.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          124 a          140 c          135 g           95 t
ORIGIN      
        1 acatgggaga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaggtggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004849             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9624:7985
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004849
VERSION     KCXD01004849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9624:7985"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63331.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          113 c          157 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactacgca gactctgtga aggcccgatt caccgtctcc agagacaatt
      361 ccaagaacat gttatatctt caaacggaca acctgaaatt ggaagacacg gccgtgtatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004850             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16223:16753
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004850
VERSION     KCXD01004850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16223:16753"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63332.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       442..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          103 a          118 c          159 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggtaaag
      181 cctggggggt ccctgagact ctcctgcgcg gcctctggat tcagcttcag ttatttctac
      241 atgagctggg tccgtcaggc tccagggaag gggctggagt ggatctcaag tattgacagt
      301 ggtgggacta ccgctaatta tgcagactcc gtgaggggca gattcatcat ctccagagag
      361 aacgccaaga atacagtgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattattgtg cgagagcgcg cggggtgatc attacatact ttgactcctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004851             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13198:18226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004851
VERSION     KCXD01004851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13198:18226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..453
     V_segment       87..376
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63333.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       388..395
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT          103 a          105 c          128 g          119 t
ORIGIN      
        1 acatggggga ctgaacacac aggactcacc atggagttta tgctgagctg ggttttcctt
       61 gttgcttatt aaaaggtgtc cagtgtgtgg agcagctggt ggaatctggg ggaggcttgg
      121 tacagcctgg ggcgtccctg agactctcct gtgcagcctc tgaattcacc ttcagtacct
      181 atgacatgca ctgggttcgc caggctccag ggaagggtct ggagtgggtt tccggtatta
      241 acattggcgg tgacacatac tacccagact ctgtgaaggg tcgattcact atctccagag
      301 acaatgccaa gaactccttg tatcttcaaa tgaacagcct gagagttgag gacactgctg
      361 tgtatttttg tacaaggggg atagataact accactttag taatacggac tttgactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004852             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12727:20229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004852
VERSION     KCXD01004852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12727:20229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63334.1"
                     /translation="CAIGPSGTWNGWSFDVW"
     D_segment       414..424
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           99 a          144 c          138 g           96 t
ORIGIN      
        1 acatgggatc acacaacagc cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgag gtgatgcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gaattgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg ggtgggaagt gttgatcctg tatatggtga aatggtgttc
      301 cagggcgggg tcaccatgac cgaggacacg tctacagaca cagcctactt ggagctcaac
      361 agcctgagct ctgaagacac ggccgtgtac tactgtgcga ttggccctag cggcacctgg
      421 aacggctggt ccttcgatgt ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01004853             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13381:13608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004853
VERSION     KCXD01004853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13381:13608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63335.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       439..445
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          124 c          149 g          114 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 cattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tcccggagac tctcctgtgc agcctccgga ttcaccttca gtacctatgc
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgca
      301 tgatggaact aagaaattct acacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatacaat atcttcacat gaacaacctg aaattggagg acacggccat
      421 atactactgt gcggcctcct acttggggta cggatttgag tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004854             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11600:3905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004854
VERSION     KCXD01004854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11600:3905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..466
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63336.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       409..415
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           89 a          136 c          140 g          103 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagttccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggacttgc gaagccttcg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcct tcagcggtta ctactggggc tggatccgcc agcccccagg ggaggggctg
      241 gagtggattg ggtatatcag tgggagtggt gggagtaccg actacaagtc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccagt tctccctgaa actgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag tccggggcgt aactatccac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004855             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17339:7849
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004855
VERSION     KCXD01004855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17339:7849"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..438
     V_segment       84..363
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63337.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       377..387
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..438
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           95 a          126 c          131 g           88 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaagtcc agctggtgca gtctggggct gaggtgaaga
      121 agcctggggc ctcagtgagg gtctcctgca ggatttccgg atacaccttc accgaattat
      181 ccatacactg ggtgcggcag gcccctggaa aagggcttga gtggatggga agtgttgatc
      241 ctctgtatgg tgaaatgaag ttccagggca gagtcaccat gaccgaggac acgtctacag
      301 acacagccta cttggaactg agcggcctga cttctgagga cacggccgtg tattactgtg
      361 cgactggccc taccggcacc tggaacgcct ggtacctcga tatctggggc cctggcaccc
      421 caatcaccat ctcctcagcc
//
LOCUS       KCXD01004856             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7995:7521
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004856
VERSION     KCXD01004856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7995:7521"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..450
     V_segment       84..376
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63338.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       383..398
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..450
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT          104 a          125 c          132 g           91 t
ORIGIN      
        1 acatgggcag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccat tctgaggtcc agctggtgca atctggggct gaggtgatgc
      121 agcctggggc ctcagtgaag gtctcctgca aggtttccgg atacaccttc accgaattat
      181 ccatacactg ggtgcgacag gcccctggaa aagggcttga gtggatggga agtgttgatc
      241 ctttatatgg tgaaatgata cacacagaac agttccaggg cagagtcacc ctgaccgagg
      301 acacgtctac agacacagcc tacatggagc tgagcagcct gagatctgag gacacggccg
      361 tgtattactg tgcgagtggc cctagcggca gctggaacga ctggtacttc gatatctggg
      421 gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01004857             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19521:16035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004857
VERSION     KCXD01004857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19521:16035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63339.1"
                     /translation="CAGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          105 a          124 c          154 g          108 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaaatgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tggggtgggt ctcagctctt aattatgatg
      301 gggatagtac atactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgcaca gcctgagaga agatgacacg gccgtttatt
      421 tctgtgcggg cggggcgtac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004858             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22242:20190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004858
VERSION     KCXD01004858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22242:20190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..401
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63340.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       417..424
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          101 a          140 c          130 g          105 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg aagctgcagg
      121 agtcgggtcc aggactggtg aagccttcag agaccctgtc cctcacctgc gctgtctctg
      181 gaggctctat cagcggtgtt tatgactgga cctggatccg ccagccccca gggaaggggc
      241 tggagtggat tgggtatgtc catggtgata ctgggaacac cgactacaac ccgtccctca
      301 agaatcgagt caccatttca aaagacacgt ccaagaacca gttctccctg acgctgaggt
      361 ctgtgaccgc cgcggacacg gccgtatatt actgtgcgag acgcccagaa aacagttact
      421 acttctacta ctttgactac tggggccacg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004859             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14890:15220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004859
VERSION     KCXD01004859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14890:15220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63341.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       430..435
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          147 c          137 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccgctc
      121 tgaggtccag ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattctcc acgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gcatatggtg aaatgacaca
      301 cgcagaaaac ttccagggca gactcaccat gaccgaggac acgtctacag acacggccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattattgtg cgagatcatc
      421 cagcggtacg tggctatact ggtacttcga tacctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004860             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13441:17988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004860
VERSION     KCXD01004860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13441:17988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..491
     V_segment       140..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63342.1"
                     /translation="CANALTGGLDYW"
     D_segment       438..446
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          107 a          123 c          156 g          107 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcac
       61 cactgaacac agaggacgca ccatggagtc tgggctgagc tgggttttcc ttgctgctat
      121 tttaagaggt gtccagtgtg aggtgcaact ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gatattggat
      241 gaactgggtc cgccaggctc cagagaaggg gctggagtgg gtctcagcta ttactagtgg
      301 tggggaaagt acacattacg cagactccgt gaagggtcga ttcaccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgga cagccttaga gcggaggaca cggccatata
      421 ttactgtgcg aacgcgttaa ctggggggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004861             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:10308:11597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004861
VERSION     KCXD01004861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:10308:11597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63343.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       406..418
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          110 a          102 c          134 g          119 t
ORIGIN      
        1 acatggggag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgttgctatt ttaagaggtg tccagtgtga ggtgcaattg
      121 gtggagtctg gaggaggctt ggttcagccg ggggggtccc tgaggctctc ctgtgcagcc
      181 tctggattca ccttcagtaa ttatggcttc cactgggtcc gccaggctcc agtgaagggg
      241 ctggagtggg ttgcagttat atcgtatgat gaaaatgtga aattctacgc agactctgta
      301 aaggaccgat tcaccatctc cagagacaat tccaagaaca tgctatatct tcaaatgaac
      361 aacctgaaat tggaggacac ggccgtgtat tactgtacga gaggggaata cagtaactct
      421 attgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004862             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:11413:10046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004862
VERSION     KCXD01004862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:11413:10046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..429
     V_segment       63..352
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63344.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       357..377
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       379..429
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           92 a          121 c          130 g           88 t
ORIGIN      
        1 acatggggga ctggacctgg aggatcctcc tcttggtggc agcagcaaca ggcgcccact
       61 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      121 tctcctgcaa ggtttccgga tactccttca ccgatttatc cattcactgg gtgcgacagg
      181 cccctggaaa agggcttgag tggatgggag gcgttgatcc tgcatatggt gaatttacac
      241 ccggagacaa gttgcagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      301 acttggacct gagcagcctg aactctgagg acacggccgt ctattactgt gcagccgggt
      361 atagcggcag ctggaaccac tggtacttcg atctctgggg ccctggcacc ccaatcacca
      421 tctcctcagc c
//
LOCUS       KCXD01004863             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21084:9627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004863
VERSION     KCXD01004863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21084:9627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63345.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       445..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          110 c          154 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcttctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgcctgg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtactactgt gggagagatg ataatggggt gattatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004864             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23750:18531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004864
VERSION     KCXD01004864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23750:18531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63346.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          109 a          119 c          156 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagg ttcaattatt actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta gtagtggtgg
      301 ggaaagcaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctatatcttc aaatggacag cctgagaact gaggacacgg ctgtctattt
      421 ctgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004865             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7263:9230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004865
VERSION     KCXD01004865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7263:9230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63347.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       398..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          141 c          133 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccacctctcc ctgcagctga attatgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagaacaagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggag tcctggtcac cgtttcctca gcc
//
LOCUS       KCXD01004866             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:6627:15138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004866
VERSION     KCXD01004866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:6627:15138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63348.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          118 c          149 g          118 t
ORIGIN      
        1 acatgggggc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcccagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaagtgcaac tggtggagtc tggaggaggc ttggttcggc
      181 ctggggggtc cctgagactc tcctgttcag cctctggatt caccttcagt aattttggca
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa gaaatactat gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa tatgctatat cttcaaatga acaacctgaa gttggaggac acggccgtct
      421 attactgtgc gagagacgca tatggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004867             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:26813:9719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004867
VERSION     KCXD01004867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:26813:9719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63349.1"
                     /translation="CATGRIGSSGWSTLFTGLDSW"
     D_segment       431..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          117 a          148 c          145 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctggg aaaggccttg agtggatggg agttgttgat cctgtcaatg gtgaagaaat
      301 acacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcgga agcagcggct ggtccaccct cttcaccggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004868             404 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:7859:4550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004868
VERSION     KCXD01004868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 404)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 404)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:7859:4550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    36..402
                     /note="immunoglobulin heavy chain variable region"
     V_region        36..402
     V_segment       36..328
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <321..>371
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63350.1"
                     /translation="CASGRSGGVWPFSFDFW"
     D_segment       340..349
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       359..402
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        403..>404
                     /gene="IGHG"
BASE COUNT           87 a          103 c          134 g           80 t
ORIGIN      
        1 acatgggggt ggcagcagct acaggcgccc actctgaggt ccaactggtg cagtatgggg
       61 ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg caaggtttcc ggacacagcg
      121 tcaccgaatt atccatgcac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg
      181 gaggtgttga ccctgtatat ggcgaggaaa tacatgcaga gaacttccag ggcagagtca
      241 ccatgaccga ggacacgtct acagacacag cctacatgga gctgactagc ctgcaatctg
      301 aggacacggc cgtgtactac tgtgcgagcg ggaggagtgg tggtgtctgg ccgttctcct
      361 ttgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004869             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:26661:9540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004869
VERSION     KCXD01004869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:26661:9540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63351.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       439..445
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          103 a          126 c          153 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcagct tcagttacta cttcatgagc
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattac cagtggtggg
      301 actaacacat actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaccacac tgtatcttca catggacagc ctgagagctg aggacacggc tgtctattac
      421 tgtgtaagag atcgacgtgt acagtcgtta tcctggttcg atgtctgggg cccgggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004870             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15559:4319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004870
VERSION     KCXD01004870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15559:4319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63352.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       402..409
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           81 a          138 c          132 g          114 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcgattactt ctggaactgg gtccgccagt ccccagggag ggggctggag
      241 tggattggat ttttctatgg tgctactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacct tttcagcaga cacgtcccag aaccagtttt ccctgaggct gacctctgtg
      361 accgccgcgg acaccgccgt ttattattgt gcgagatatc agggtgattc cttgtactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004871             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19838:7409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004871
VERSION     KCXD01004871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19838:7409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63353.1"
                     /translation="CVSNLRGNTYTYWRSFDFW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          111 a          132 c          157 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtagt aatagaaact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg agacctgagg acacggccgt
      421 gtattactgt gtgtcgaacc tacgtggaaa cacctacact tactggcggt cctttgactt
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004872             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14350:10094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004872
VERSION     KCXD01004872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14350:10094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..424
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63354.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       435..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          102 a          124 c          153 g          113 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacacaccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc attgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctaa gactctcctg tgaagcctcc gggttcacct tcagtgacca ctgcatacac
      241 tgggtccgcc aggcttcagg gaaggggctg gagtgggtct caggtattac ttatactggt
      301 gttaccacat ggtacgcaga ctccgtgagg ggcagattca ccatctccag agagaacacc
      361 aagaacacac tgtatcttca aatggacagc ctgagagctg aggacacggc tgtctatttc
      421 tgtgtggcag gaaggcggca cgtggacctt gactactggg gccagggagt cctggtcgcc
      481 gtctcctcag cc
//
LOCUS       KCXD01004873             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6559:8396
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004873
VERSION     KCXD01004873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6559:8396"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63355.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          106 a          123 c          157 g          128 t
ORIGIN      
        1 acatggggag ctctgagaca ggagtcttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtggagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgtagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagaaacac
      301 tggtaagatc gtatactacg ctgactccgt gaagggccga ttcatcatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gtcgaggact cggccgtcta
      421 ttactgtact agaattggcg tcggatctct agcaccggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004874             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16443:4257
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004874
VERSION     KCXD01004874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16443:4257"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63356.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          141 c          135 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctgtggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtgcttc gatatctggg gccctggcac cccgatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01004875             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13498:14747
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004875
VERSION     KCXD01004875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13498:14747"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63357.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       411..421
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          138 c          146 g          106 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacagcttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt tactgtactg
      421 gcaatggttg taaccttact ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004876             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5880:11361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004876
VERSION     KCXD01004876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5880:11361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63358.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          110 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcggctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtagc tactggaact ggatccgcca gccccctgga aagggactgg
      241 agtggattgg gtatatctct ggcgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtttattatt gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004877             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:22160:11151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004877
VERSION     KCXD01004877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:22160:11151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63359.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       439..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          103 a          125 c          155 g          113 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccattgtg aggtgcagct ggtggagtcg gggggcggct tggcaaagcc
      181 tggggggtcc ctaagactct cctgtgcagc ctccggattc accttcagtg accactgcat
      241 gcactgggtc cgccaggctt cagggaaggg gctggaatgg gtctcaggta tcacttatac
      301 tggtgttacc acatggtacg cagactccgt gaggggcaga ttcaccatct ctagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgtg ggaggaaggc ggcacgtgga ccttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004878             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13432:17155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004878
VERSION     KCXD01004878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13432:17155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63360.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          144 c          137 g           96 t
ORIGIN      
        1 acatggggag catcacacaa cagccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagctg caggcgcccg
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc gaggtttccg gatacacctt caccgaactg tccatccact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aagtgttgat cctgaatatg gtgaaatgat
      301 aaacgcagaa aaattccagg gcagagtcac cttgaccgag gacacgtcta caggaacggc
      361 ctacatggag ctgatcagtc tgagatctga agacacggcc gtgtattact gtgcgacatc
      421 acccagcggc acctggctat attggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004879             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23007:18815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004879
VERSION     KCXD01004879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23007:18815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63361.1"
                     /translation="CARDVYGTGFDYW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          109 a          118 c          152 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ggttatatcg
      301 tctgatgcaa ataacatata ctacgcagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct ctatcttcaa atgggcaacc tgaaattgga ggacacggcc
      421 gtgtattatt gtgcgagaga tgtctacggt accggatttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004880             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:21675:11554
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004880
VERSION     KCXD01004880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:21675:11554"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63362.1"
                     /translation="CARDDSGTGFDYW"
     D_segment       439..447
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          110 c          153 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactt accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 tcttaagagg tgtccagtgt gaagtgcaac tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactatggca
      241 tgcactgggt ccgcctggct ccagggaagg gtctggagtg ggtggcagtt atgtcgaatg
      301 atggaattaa taagtactac gcagactctg tgaaggaccg atacaccatc tccagagaca
      361 attcgaggaa catgctgtat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgtgc gagagatgat agtgggaccg gttttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004881             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:4984:11880
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004881
VERSION     KCXD01004881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:4984:11880"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63363.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          140 c          151 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgcgcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004882             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:7218:18789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004882
VERSION     KCXD01004882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:7218:18789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..472
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63364.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..417
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          136 c          138 g          106 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccaggtgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaggcc ttcggagacc ctgtccctca cctgcgttgt ctctggtgac
      181 tccttcagcg gttactactg gagctggatc cgccagtccc cagggacggg gctggagtgg
      241 attgggtata tcagtgctag tagtgggagc accgactaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cagttctccc tgaagctgag ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagagaaat attatagtgg tagttataaa
      421 cacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004883             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12628:3576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004883
VERSION     KCXD01004883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12628:3576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..487
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63365.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       421..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>490
                     /gene="IGHG"
BASE COUNT          118 a          144 c          132 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat tcaccttcac cgatttatcc atacactgga tacgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcatatggtg aaatgataaa
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggaattg agcagcctga aatctgacga cacggccgta tattactgtg cgagtggccc
      421 tagcggcacc tggatcgact ggtccttcga tgtctggggc cctggcaccc caatcaccgt
      481 ctcctcaacc
//
LOCUS       KCXD01004884             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14821:14166
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004884
VERSION     KCXD01004884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14821:14166"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63366.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       433..444
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          110 a          116 c          150 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc attgtgaggt gcagctggtg gagtctggag gaggcttggt tcagccgggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaacta tggcatgcac
      241 tgggtccgcc aggctccagg gaagggtctg gagtgggtgg cagttatgtc gcatgatgga
      301 actaagaaat tctacgcaga ctctgtgaag gaccgattca ccatctccag ggacaattcc
      361 aagaacatgg tatatcttca aatgaacaac ctgagattgg aggacgcggc cgtctattat
      421 tgtgcgagag gagactacgg taacagcctt gacttctggg gccagggagt cctgctcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01004885             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18292:16441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004885
VERSION     KCXD01004885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18292:16441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63367.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          113 a          145 c          131 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg taaagtggac
      301 tacacacaga agttccgaga cagactcacc atcaccgcgg acatgtcgac agagacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga ctactggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004886             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17691:9755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004886
VERSION     KCXD01004886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17691:9755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63368.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          113 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaactggtg gatatggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004887             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24013:4282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004887
VERSION     KCXD01004887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24013:4282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..462
     V_segment       84..376
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63369.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       398..404
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..462
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT          103 a          120 c          146 g           95 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaggtcc agctggtgca gtctggggct gaggtgaaga
      121 agcctggggc ctcagtaaag gtctcctgcc aggtttccgg agacaccttc agtgaaatgt
      181 ccatacactg ggtgcgacag gcccctggaa aagggcttga gtggatggga tgtgttgctc
      241 ctggaaatgg ggaaataata cacgcagata acttccaggg cagagtcacc atgaccgagg
      301 acacgtctat agacacagcc tacatggagc tgagtagcct gagatctgag gacacggccg
      361 tatattactg tgcgagcggg acatttggga ccagcgtctg gtccagcctc ttctacggtt
      421 tggattcctg gggccaaggg gtcgtcgtca gcgtctcctc agcc
//
LOCUS       KCXD01004888             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20722:14711
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004888
VERSION     KCXD01004888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20722:14711"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..468
     V_segment       108..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63370.1"
                     /translation="CAATGEPLEYFDFW"
     D_segment       410..414
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..468
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           93 a          133 c          141 g          103 t
ORIGIN      
        1 acatgggggg gaaatgttct ctgagagtca tggacctcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcagctgc
      121 aggagtcggg cccaggagtg gtgaggcctt cagagaccct gtccctcacc tgcgctgtct
      181 ctggaggatc tatcagcagt ggttatgact ggagctggat ccgccagccc ccagggaagg
      241 ggctggagtg gattgggtat atctatggta ctagtgggag caccaactac aatgcgtccc
      301 tcaagaatcg agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgcagttga
      361 ggtctgtgac cgccgcggac acggccgttt attactgtgc ggcgacaggg gaaccccttg
      421 aatacttcga cttctggggc cagggcgccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004889             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13547:2418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004889
VERSION     KCXD01004889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13547:2418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63371.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          119 a          143 c          146 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaaatgaa gaagcctggg gcctcagtta
      181 gggtctcctg caaggtttcc ggaaacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgtcga tcctgcacaa ggtgaaataa
      301 tacacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct gcagacacag
      361 ccttcatgga gttgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgaaag
      421 gggggttcgg aaccagcgtc tggtccaacc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004890             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13506:13579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004890
VERSION     KCXD01004890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13506:13579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63372.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       428..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          125 c          147 g          104 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccccacag aagccccaga gcaaagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcggccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacagtgtca ccgaattatc gattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgtaaaaggt gaagaaattc
      301 acggagagga gttccaggac agagtcacca tgaccgagga cccgtctaca gacacagcct
      361 acatggagtt gagcaacctg agatctgagg acacggccgt gtattattgt gcgagtgggt
      421 ttagtatctg gttattttac gacgttttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004891             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16981:11870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004891
VERSION     KCXD01004891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16981:11870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..488
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63373.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>491
                     /gene="IGHG"
BASE COUNT          115 a          144 c          138 g           94 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg acgtgaagaa gcctggggcc tctgtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgagttatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttcag tggatgggaa gtgttgatcc tgcatatggt gaaatgataa
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ctatttctgt gcgagtggcc
      421 ctagcggcag ctggaacggc tggtacttcg atatctgggg ccctggcacc cctatcaccg
      481 tctcctcaac c
//
LOCUS       KCXD01004892             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:8236:14060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004892
VERSION     KCXD01004892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:8236:14060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63374.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       406..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          105 a          135 c          141 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga tttgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcctgaa tatggtgaaa tgacgttcca
      301 ggggagagtc accatgaccg aggacacgtc tacagacacg gcctacatgg agctgagtag
      361 cctgagatct gaggacacgg gcgtgtatta ctgtgcgatt ggccctagcg gcaggtggaa
      421 ccactggtcc ttcgagatct ggggacctgg gaccccaatc accatctcct cagcc
//
LOCUS       KCXD01004893             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23293:14696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004893
VERSION     KCXD01004893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23293:14696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63375.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          118 c          148 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctgggggag gcttcgttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gaaactttgg
      241 catacactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag tcatttcgtc
      301 tgatggaact aagatatact acgcaaactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gagtaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004894             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17796:12628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004894
VERSION     KCXD01004894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17796:12628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63376.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          120 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gatgctggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004895             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13973:5537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004895
VERSION     KCXD01004895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13973:5537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63377.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          135 c          136 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcac tgtctctggt
      181 ggctccttca gtggttacta ctggacctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttatcggtgg tggtagtggg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tgtcaagaga cacgtccaag aatcaattct ccctgaagat gacctctatg
      361 accgccgcgg acacggccgt ttatttctgt gccagagatg cgggagtggg agccacaatc
      421 ctttattact atgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004896             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:20055:9244
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004896
VERSION     KCXD01004896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:20055:9244"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63378.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       268..273
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           80 a           77 c           91 g           73 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagcaccttt
       61 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      121 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga
      181 gacaattcca aaaacatggt atattttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtatattact gtgcgagaga tgtcagggga acgggatttg acttctgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004897             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17476:16827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004897
VERSION     KCXD01004897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17476:16827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63379.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           94 a          149 c          133 g          111 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctccc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggctactact ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actattcttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01004898             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11966:4626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004898
VERSION     KCXD01004898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11966:4626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63380.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       430..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          124 c          149 g          105 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcggcca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacagtgt caccgaatta tcgattcact gggtgcgaca
      241 ggccccggga aaagggcttg agtggatggg aggtgttgat cctgtaaaag gtgaagaaat
      301 tcacggagag gagttccagg acagagtcac catgaccgag gacccgtcta cagacacagc
      361 ctacatggag ttgagcaacc tgagatctga ggacacggcc gtgtattatt gtgcgagtgg
      421 gtttagtatc tggttatttt acgacgtttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004899             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20389:14020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004899
VERSION     KCXD01004899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20389:14020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63381.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          111 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgtaac taagaaatat tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaataacct gaaaatggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004900             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12427:6735
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004900
VERSION     KCXD01004900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12427:6735"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..496
     V_segment       133..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <415..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63382.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       427..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..496
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          123 a          143 c          134 g           98 t
ORIGIN      
        1 acatgggggt ccagagagca tcacacaaca accacatccc tcccctacag aagccccaga
       61 gcatagcacc tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca
      121 ggcgcccact ctgaggtcca ggtggtgcag tctggggctg aggtaaagga gcctggggcc
      181 tcagtaaagg tctcctgcaa ggtttccgga ttcaccttca ccgaattatc catgcactgg
      241 gtgcgacagg cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt
      301 gaaatgaaac acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac
      361 acagcctaca tggagttgag cagcctaaga tctgaggaca cggccctgta ttactgtgca
      421 gtcggctata gcggcagatg gaacaactgg tacttcgatc tctggggccc tggcacccca
      481 atcaccatct cctcagcc
//
LOCUS       KCXD01004901             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18627:14751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004901
VERSION     KCXD01004901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18627:14751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63383.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          113 a          144 c          130 g           91 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtggacta
      301 cacacagaag ttccgagaca gactcaccat caccgcggac atgtcgacag agacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004902             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21610:13501
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004902
VERSION     KCXD01004902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21610:13501"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63384.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       447..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttaaatcgt
      301 ttgatggaac caagatatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcctacggga gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004903             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10095:19751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004903
VERSION     KCXD01004903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10095:19751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63385.1"
                     /translation="CATGHSGRWINWYFEIW"
     D_segment       420..427
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          138 c          136 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagccacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gcttatggtg aaatggtaaa
      301 cgcagagaag ttccaggaca gagtcaccat gaccgaggac acgtccacag acacagccta
      361 catggagtta gtgagtctga catctgagga cacggccgtg tattactgtg caacaggcca
      421 tagtggcagg tggattaact ggtacttcga aatctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01004904             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17971:18268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004904
VERSION     KCXD01004904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17971:18268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..522
     V_segment       153..444
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <438..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63386.1"
                     /translation="CARLWGDIYALQYYFDYW"
     D_segment       449..458
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..522
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT           97 a          161 c          142 g          124 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg ccgaggtgca gctggtgcag tctggagcag
      181 aggtgaagag gcccggggaa tctctgagga tctcctgtca gacttctgga tacagttttg
      241 ccaactactg gatcgcctgg gtgcgccaga tgcccgggaa aggcctggag tggatgggga
      301 tcatctatcc tggtgattct gacaccaagt acggcccgtc cttcgaaggc cagttcacca
      361 tctcagccga caagtccacc agcaccgcct acctgcagtg gagcagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagactct ggggtgatat ttacgcactc cagtactact
      481 tcgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004905             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:28605:9743
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004905
VERSION     KCXD01004905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:28605:9743"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63387.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          123 a          142 c          133 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aacgtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01004906             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:9315:17733
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004906
VERSION     KCXD01004906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:9315:17733"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63388.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          123 a          138 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcacccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004907             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14740:16230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004907
VERSION     KCXD01004907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14740:16230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63389.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          113 c          154 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccaatcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcc
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattccc catctccaga
      361 gacaattcca aaaacatgat atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattatt gtgtgagaga tgtcagggga acggggtttg actactgggg ccggggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004908             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16252:17949
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004908
VERSION     KCXD01004908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16252:17949"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63390.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       430..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          147 c          147 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtca ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggag ttgttgatcc tgtcaatggt gaagaaattc
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatcggtgg cagcggctgg tccaacctct tcaccggttt ggaatcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01004909             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20950:9725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004909
VERSION     KCXD01004909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20950:9725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63391.1"
                     /translation="CVRDAYGGGWDSW"
     D_segment       450..458
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          117 c          156 g          122 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga gtgggtggcg gttatatcgt
      301 ttgatgatag taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaga tgaacaacct gaaattggag gacacggccc
      421 tttattactg tgtgagagat gcttacggtg gtggctggga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004910             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18054:20510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004910
VERSION     KCXD01004910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18054:20510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63392.1"
                     /translation="CTTWTTGYNYYFAYFDSW"
     D_segment       406..414
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          138 c          131 g          113 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggagcggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcgacacta acaggtggag ttggatccgc cagtccccag ggaagggact
      241 ggagtggatt ggatacatcg atggttctag tacgcgcacc gactatattc cctccctcaa
      301 aagtcgagtc accatttcaa aagacacgtc caggaaccag ttctccttga ggctgaattc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtacgact tggacgactg gttacaatta
      421 ttatttcgcc tactttgact cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004911             395 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24543:4225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004911
VERSION     KCXD01004911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 395)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 395)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24543:4225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..393
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..393
     V_segment       33..325
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <318..>362
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63393.1"
                     /translation="CASLGLIEQEGVNSW"
     D_segment       349..354
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       355..393
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        394..>395
                     /gene="IGHG"
BASE COUNT           84 a          103 c          115 g           93 t
ORIGIN      
        1 acatgggggc agctcccaga tgggtcctgt cccaggtaca actgcaggag tcgggcccag
       61 gattggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctgga ggctctatca
      121 gcagtggtta tgactggagt tggatccgcc agcccccagg gaaggggcta gagtggattg
      181 gatatatcca tggtagtcgt ggaatcaatt ataagccgtc cctcatgaat cgagtcacta
      241 tttcaaaaga cgcgtccaag aatcagtttt ccctgaagct gagctctatg accgccgcgg
      301 acacggccgt ctattactgt gcgagccttg gtttaattga acaggagggt gtgaattcct
      361 ggggccaagg ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01004912             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17654:18365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004912
VERSION     KCXD01004912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17654:18365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63394.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       409..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          149 c          130 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttcagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      301 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg gttggcccta gcggcacttg
      421 gaaccactgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01004913             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7574:6172
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004913
VERSION     KCXD01004913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7574:6172"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63395.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          117 c          154 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaagtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcgg ttatatccaa
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcagca tttccaggga
      361 caaccccaag aacatgctat atcttcaaat gaacaacctg aaattggatg acacggccgt
      421 ctattactgt gcgacagatg cgtttggtag cgggattgac tactggggcc ggggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004914             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11821:16059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004914
VERSION     KCXD01004914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11821:16059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63396.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          140 c          134 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgagttatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004915             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13407:8725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004915
VERSION     KCXD01004915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13407:8725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63397.1"
                     /translation="CARGSNVWVPDFDYW"
     D_segment       428..435
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          117 a          132 c          144 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacagcgtca ccgaattatg catacactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgtaaatgag gcaataatag
      301 acgctgagaa cttccagggc agactcacca tgaccgagga cacgtctact gacacagcct
      361 acatggagct gaggagcctg agatctgagg acacggccgt gtattattgt gccagaggga
      421 gcaacgtgtg ggtaccggac tttgactact ggggccaggg agtcctggtc accgtctctt
      481 cagcc
//
LOCUS       KCXD01004916             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6566:17266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004916
VERSION     KCXD01004916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6566:17266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63398.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       412..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          106 a          137 c          143 g           95 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgatttg tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgaatatg gtgaaatgac
      301 gttccagggg agagtcacca tgaccgagga cacgtctaca gacacggcct acatggagct
      361 gagtagcctg agatctgagg acacgggcgt gtattactgt gcgattggcc ctagcggcag
      421 gtggaaccac tggtccttcg agatctgggg acctgggacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01004917             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14304:6966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004917
VERSION     KCXD01004917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14304:6966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63399.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          143 c          134 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccattc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgatgcag cctagggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ttatatggtg aaatgataca
      301 cacagaacag ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cgagtggccc
      421 tagcggcagc tggaacgact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01004918             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10859:14707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004918
VERSION     KCXD01004918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10859:14707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63400.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          118 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004919             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18523:11791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004919
VERSION     KCXD01004919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18523:11791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..453
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63401.1"
                     /translation="CGSPLNWKASW"
     D_segment       404..412
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           82 a          136 c          136 g          101 t
ORIGIN      
        1 acatggggga ttgctctctg cgagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gccccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctatc tctcagttgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg atttatcggt ggtagtagtg ggagcaccta ctacaatccc tccctcaaga
      301 gtcgagtcac catttcagta gacacgtcca agacccggtt ctccctgaaa ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgggagccc ccttaactgg aaagcatctt
      421 ggggccaggg agtcccggtc accgtctcct cagcc
//
LOCUS       KCXD01004920             424 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:15136:12617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004920
VERSION     KCXD01004920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 424)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 424)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:15136:12617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..422
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..422
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>391
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63402.1"
                     /translation="CARVGEGSGGAEDFDFW"
     D_segment       359..367
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       378..422
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        423..>424
                     /gene="IGHG"
BASE COUNT           91 a           92 c          134 g          107 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 acaactggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tacagcctct ggattcacct tcagtagctt tggcatacac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cacttatatc gtatgatgga actaagaaat actacgcaga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc gagaacatgc tatatcttca
      301 aatgaacaac ctgaaattgg aggacacggc cgtgtatttc tgtgcgagag ttggagaggg
      361 tagtggtggt gcggaggact ttgacttctg gggccaggga gtcctggtca ccgtctcctc
      421 agcc
//
LOCUS       KCXD01004921             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14776:18860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004921
VERSION     KCXD01004921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14776:18860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..498
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63403.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       433..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          136 c          149 g          101 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgcaa ggcttctgga tacaccttca gcatctatgt catcaattgg gtgcgacagg
      241 cccctggaca agggctagag tggatgggag ggatcatccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga tttttgcgga cacgtccaca agcacagcct
      361 acatggaatt gagaagcctg agatctgagg acacggccgt gtattactgt gcgagaggcc
      421 cccctactga agggggtgat tattctgggg gggctttgag ccgatggggc cagggagtcc
      481 aggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004922             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15650:12088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004922
VERSION     KCXD01004922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15650:12088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63404.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       445..453
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          110 a          115 c          153 g          118 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcacta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcggtta catcgtttga
      301 tgaaagtaag aaatactacg cagactctgt gaaggaccga ttcaccattt ccagagacaa
      361 ttcaaagaac atgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttactgtgtg agagatgctt acggtagtgg ctgggactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01004923             434 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8701:14098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004923
VERSION     KCXD01004923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8701:14098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..432
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..432
     V_segment       63..356
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>401
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63405.1"
                     /translation="CARERCSASSCAGFLDSW"
     D_segment       362..369
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..432
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        433..>434
                     /gene="IGHG"
BASE COUNT           92 a          118 c          135 g           89 t
ORIGIN      
        1 acatggggga ctggacctgg aggctcctct ttgtggtggc agcagctaca ggtgtccagt
       61 cccaggtcca gctggtacag tccggggctg aggtgaagaa gcctggggcc tcagtgaaag
      121 tttcctgcaa ggcttctgga ttcaccctcg acaactatgg catcaactgg gtgcgccagg
      181 cccccggaca ggggcttgag tggatgggag tgatcatccc ccttattgga ataataaact
      241 acgcagagaa cgtccagggc agagtcgcga tttccgcgga cacgtccata aatacagcct
      301 acatggaggt gcgcagcctg agatctgagg acacggccat ctattactgt gcgcgagaac
      361 gttgtagtgc tagcagttgc gccggattcc tagactcctg gggccaggga gccctggtca
      421 ccgtctcctc agcc
//
LOCUS       KCXD01004924             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6485:16112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004924
VERSION     KCXD01004924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6485:16112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63406.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          113 c          151 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gctgctgttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagagcat gctctatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatatg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004925             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20265:10097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004925
VERSION     KCXD01004925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20265:10097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..493
     V_segment       140..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63407.1"
                     /translation="CATADYGNSLDYW"
     D_segment       437..448
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>496
                     /gene="IGHG"
BASE COUNT          110 a          117 c          148 g          121 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actttggcat
      241 gcactgggtc cgccagggtc cagggaaggg gctggagtgg gtggcagtta tatcgtctga
      301 tggaagtttc aaatactacg cagactctgt gaagggccga ttcaccattt ccagagacaa
      361 ttccaagaac atggtatatc ttcaaatgaa caacctgaaa ttggaggaca ctgcccttta
      421 ttactgtgcg acagccgact acggtaacag ccttgactac tggggtcagg gagtcctggt
      481 caccgtctcc tcaacc
//
LOCUS       KCXD01004926             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22533:9576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004926
VERSION     KCXD01004926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22533:9576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63408.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       406..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          136 c          135 g          110 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg caggtcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc accagtagct tctggaactg gattcgccag cccccagggg aggggctgga
      241 gtggattggg tatatctctg gtgctactgg gagtaccagc tacagcccat ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tcgctgaggc tgaactctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat gacgcggatg attacggtta
      421 ttattacctt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004927             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20846:10025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004927
VERSION     KCXD01004927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20846:10025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63409.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       400..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           89 a          135 c          133 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcaat tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc atttactact ggaattggat ccgccaggcc ccagggaagg gactggactg
      241 gattggacat atctatggga gcggtggtag caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagttctcc ctgaacctga ggtctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagcggtcgg cggcagctgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004928             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12434:10337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004928
VERSION     KCXD01004928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12434:10337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63410.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          118 c          151 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 ttagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gtccagcctg
      181 ggggctccct gagactctcc tgtgcagcct ctggattcac cttcaatacc tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcacatgatg
      301 aaactaagag atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgagca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agacgcattt ggcagcggct gtgactactg gggccgggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004929             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7410:16671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004929
VERSION     KCXD01004929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7410:16671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63411.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtgg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaacttggag gacacggccg
      421 tctattactg tgcgagggac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004930             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6389:11559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004930
VERSION     KCXD01004930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6389:11559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63412.1"
                     /translation="CAAGYSGSWNHWYFDRW"
     D_segment       413..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          142 c          140 g           90 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gcaacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaacga attatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggagt tgatcctgca tatggtgaat ttacagccgg
      301 agaggagttc cagggcagag tcaccatgac cgaggacacg tccatagaca cagcctacat
      361 ggagctgagc agcctgaact ctgaggacac ggccgtctat tactgtgcag ccgggtatag
      421 cggcagctgg aaccactggt acttcgatcg ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01004931             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15233:12177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004931
VERSION     KCXD01004931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15233:12177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    66..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        66..429
     V_segment       66..359
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <351..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63413.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       369..375
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       385..429
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           91 a           97 c          135 g          108 t
ORIGIN      
        1 acatgggcat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg aaaggtgtcc
       61 agtgtgaggt gaagctggtg gagtctgggg gcggcttggc aaagcctggg gggtccctga
      121 gactctcctg cgcagcctct ggattcagct tcaattatta ctatatgagt tgggtccgcc
      181 aggctccagg gaaggggctg gagtggatct caggtattaa tagtggtggg gaaagcacat
      241 actctgcaga ctccgtgaag ggcagattca ccatctccag agagaacgcc aagaaaacag
      301 tatatcttca aatggacagc ctgagaactg aggacacggc tgtctattac tgtgtgagag
      361 atcgacgtgt acagtcctta tcctggttcg atgtctgggg cccgggagcc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01004932             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14064:16969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004932
VERSION     KCXD01004932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14064:16969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63414.1"
                     /translation="CVRDGYGSGLDAW"
     D_segment       297..306
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           80 a           76 c          113 g           81 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcggggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agcacgtttg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttataacga atgatggaag taagaattac tacgcagact
      181 ctgtgaagga ccgattcacc gtctccagag acaattccaa gaatatggta tatattcaaa
      241 tgaacaacct gaaattggag gacacggccg tttattactg tgtgagagat gggtacggta
      301 gtggtttgga tgcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004933             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5978:10371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004933
VERSION     KCXD01004933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5978:10371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63415.1"
                     /translation="CARDAFGSGFDYW"
     D_segment       450..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          147 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgca gtgggtggca gttatttcgc
      301 atgatgaaaa taatatatac tacgcagact ctgtgaagga ccgtttcacc atctccagag
      361 acaattccaa gaacgcggta tatcttcaaa tgagcaacct gaaattggat gacacggcca
      421 tctattactg tgcgagagac gcatttggta gcggctttga ttattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004934             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14271:20960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004934
VERSION     KCXD01004934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14271:20960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..491
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63416.1"
                     /translation="CARDAGYGDTISLVDINMFPHFDYW"
     D_segment       412..435
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          100 a          134 c          140 g          119 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tggaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgctg tctctggtgc
      181 ctccatcagt agttactggt ggagttggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggta atagtggtag tatttactac aacccttccc tcatcagtcg
      301 agtctccatt tcaaaagacg cgtccaagaa tcagttctcc ctgaagctaa gctctgtgac
      361 cgccgcggac acggccgtct attactgtgc gagagatgcc gggtatgggg atacgatatc
      421 actagtcgat attaatatgt ttccccactt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004935             373 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16906:18062
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004935
VERSION     KCXD01004935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 373)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 373)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16906:18062"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    17..371
                     /note="immunoglobulin heavy chain variable region"
     V_region        17..371
     V_segment       17..310
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <302..>340
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63417.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       320..325
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       329..371
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        372..>373
                     /gene="IGHG"
BASE COUNT           80 a           84 c          118 g           91 t
ORIGIN      
        1 acatggggtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg ttcagcctgg
       61 ggggtccctg agactctcct gtgcagcctc tggattcatg ttcagtaact ttggcatcca
      121 ctgggtccgc caggctccag ggaaggggct ggagtgggtg tcagttatat cgtatgatgt
      181 aactgtgaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      241 caagaacacg ctatatcttc aaatgcacaa cctgaaattg gaggacacgg ccgtgtatta
      301 ttgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      361 cgtctcgtca gcc
//
LOCUS       KCXD01004936             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:26759:13165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004936
VERSION     KCXD01004936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:26759:13165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63418.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       420..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          146 c          140 g           94 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagca acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccggatt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggcgttga tcctgcatat ggtgaattta
      301 cacccggaga gaagttccag ggcagagtca ccatgaccga ggacacgtct atagacacag
      361 cctacatgga gctgagcagc ctgaactctg aggacacggc cgtctattac tgtgcagccg
      421 ggtatagcgg cagctggaac cactggtact tcgatctctg gggccctggc acccctatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01004937             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20945:2420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004937
VERSION     KCXD01004937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20945:2420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63419.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       418..429
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          139 c          137 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aagaaccttc accgaattat ccatgcactg ggtgcgacat
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga gatctgagga cacggccgtc tattactgtg cgattggccc tagtggcagc
      421 tggaacgact ggtccttcga catttgggga cctggcaccc caatcaccgt ctcctcagcc
//
LOCUS       KCXD01004938             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18721:18535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004938
VERSION     KCXD01004938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18721:18535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63420.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       397..405
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          133 c          130 g          115 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgttca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaaa tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gaagtaacta ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggataggtt atgtctatgg tgatagtggg aacaccgaat acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga ctcgtccaag aatcagtttt ccctgaagct gagttctgtg
      361 accgccgcgg acaccgccgt gtatcactgt gcgagataca gttacggttc caactacttc
      421 tttgggttct ttgactattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004939             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12014:16452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004939
VERSION     KCXD01004939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12014:16452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63421.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          114 c          150 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtcca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaaatc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004940             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11349:19420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004940
VERSION     KCXD01004940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11349:19420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63422.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          114 c          154 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgacctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagaga tgtcagggga acggggtttg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01004941             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17071:3280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004941
VERSION     KCXD01004941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17071:3280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63423.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       442..450
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          111 c          155 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gaggctctcc tgtgcagcct ctggattcac cttcagtcac tatggcgttc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaaataagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaagaccat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgtcaga ggcggtggct ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004942             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:26559:7231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004942
VERSION     KCXD01004942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:26559:7231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..463
     V_segment       108..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63424.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>469
                     /gene="IGHG"
BASE COUNT           94 a          132 c          131 g          112 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccgggtgc agctgcagga
      121 gtcgggccca ggactggtga agtcttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tgactccatc agcaatagct attggaactg gatccgccag ccccctggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tccgcagcc
//
LOCUS       KCXD01004943             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14743:5879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004943
VERSION     KCXD01004943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14743:5879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63425.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       460..467
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          113 a          132 c          159 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gcaattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtc
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgacct gggtccgcca ggctccaggg aaggggctgg agtgggtctc atacattagt
      301 attggtggta gaaatagaaa ctacgcagac tccgtgaagg gccgattcac catctccaga
      361 gacaactcag agaaaacgct ctccctgcaa atgaacagcc tgagacctga ggacacggcc
      421 gtgtattact gtgcgtcgaa cctgcgtgga aacacctaca cttactggcg gtcttttgac
      481 tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004944             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20290:15264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004944
VERSION     KCXD01004944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20290:15264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63426.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          111 a          143 c          151 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccgc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgacttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgacc ctgcaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gcgatctgag gacacggccg tttattactg tgcgagaggg
      421 ggcttcggta gcagtgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgccgtca ccgtctcctc agcc
//
LOCUS       KCXD01004945             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14488:6628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004945
VERSION     KCXD01004945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14488:6628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63427.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          102 a          125 c          162 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agcctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag ggattaacag
      301 tggtggggat actacatacc acgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccagg aacacactgt ctcttcaaat ggacggcctg agagctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatct tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004946             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13604:10201
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004946
VERSION     KCXD01004946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13604:10201"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..520
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63428.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       446..465
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..520
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          112 a          130 c          155 g          125 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttacgacatg
      241 acctgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagttacact
      301 ggtaaaacca tatactactc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaact ctctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgttcta gagcggctta cgaacatgat gacggttact attacgtcgg caggtttttt
      481 gactgctggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01004947             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19802:4432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004947
VERSION     KCXD01004947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19802:4432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63429.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtga aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcgtccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gtatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004948             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19132:5832
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004948
VERSION     KCXD01004948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19132:5832"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..508
     V_segment       139..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63430.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       436..456
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..508
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          117 a          119 c          158 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccaggcctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt ggtctgacct gggttttcct tgttggtatt
      121 ttgaaaggtg tccagtgtga ggtgcagctg gtggagtctg gaggagcctt ggctcagcct
      181 ggggggtccc tgagactctc ctgtgcagcg tctgggttca ccttcagtag ctatgccatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagccat atcatttgat
      301 ggaagtaaga aaaactacgc agactctgtg aaggaccgat tcaccatctc cagagacaac
      361 tccaacaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtatac
      421 tactgttcga gggaatggat acagtgggca cagttagtga gcggtttgga ttcctggggc
      481 caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004949             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18768:6450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004949
VERSION     KCXD01004949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18768:6450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63431.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       442..447
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          115 c          153 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagagcaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccaatgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtat ctctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttaa atcgtttgat
      301 ggaactaaga tatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaact tggaggacac ggccgtttat
      421 tactgtgtga gagatgccta cgggagcggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01004950             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:18579:7511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004950
VERSION     KCXD01004950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:18579:7511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63432.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          140 c          137 g           94 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaagtccaag gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 gtccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcgtca gcc
//
LOCUS       KCXD01004951             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22880:18297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004951
VERSION     KCXD01004951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22880:18297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..491
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63433.1"
                     /translation="CATADYGNSLDFW"
     D_segment       435..446
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          110 a          120 c          148 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtcggg gggaggcttg attcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 gaagtatgac atactacgca gactctatga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caagtgaaca acctgaaatt ggaggacact gccgtttatt
      421 actgtgcgac agccgactac ggtaacagcc ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01004952             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:25901:4642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004952
VERSION     KCXD01004952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:25901:4642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63434.1"
                     /translation="CARSWGRWSAEYVDFW"
     D_segment       451..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          120 c          152 g          125 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtctttgct gagctggatt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtagctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtatca ggtattagca
      301 ttggcggtac cacatactac ccagacgcta tgaagggtcg attcaccatc tccagagaca
      361 ataccgagaa gtccttgtat cttcaaatga acagcctgag agctgaggac actgctgtgt
      421 atttttgtgc aagatcatgg ggcaggtggt cagcggaata cgtcgacttc tggggccagg
      481 gcgccctggt cattgtctcc tcagcc
//
LOCUS       KCXD01004953             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14185:10311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004953
VERSION     KCXD01004953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14185:10311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63435.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       436..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          120 c          146 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcacc ttcactacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat cgtttgatga
      301 aactaaggaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtgtatta
      421 ctgtgtgaga gattcttacg gccgaggctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004954             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:16857:7014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004954
VERSION     KCXD01004954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:16857:7014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63436.1"
                     /translation="CAVGPTGTWNHWSFDFW"
     D_segment       419..424
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          150 c          129 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtctccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      301 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgca gttggcccta ccggcacttg
      421 gaaccactgg tccttcgatt tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01004955             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:24160:14908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004955
VERSION     KCXD01004955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:24160:14908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63437.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       438..450
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          111 c          147 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccgt tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctg
      121 ttttaagagg tgtccagtgt gaggtgcaat tggtggagtc tggaggaggc ttgattcagc
      181 ctggggggtc cctgaggctc tcctgtgcag cctctggatt caccttcagt aattatggct
      241 tgcactgggt ccgccaggct ccagtgaagg ggctggagtg ggttgcagtt atatcgtatg
      301 atgaaaatgt gaaatactac gcagactctg taaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagaggggaa tacagtaact ctattgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004956             304 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19900:5118
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004956
VERSION     KCXD01004956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 304)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 304)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19900:5118"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..302
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..302
     V_segment       8..225
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>271
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63438.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       229..250
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       256..302
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        303..>304
                     /gene="IGHG"
BASE COUNT           77 a           73 c           88 g           66 t
ORIGIN      
        1 acatgggggg ttcaccttca gtagctatgc catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggctg ccatatcatt tgatggaagt aagaaaaact acgcagactc
      121 tgtgaaggac cgattcacca tctccagaga caactccaac aacatgctat atcttcaaat
      181 gaacaacctg aaattggagg acacggccgt atactactgt tcgagggagt ggatacagtg
      241 ggcacagtta gtgagcggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc
      301 agcc
//
LOCUS       KCXD01004957             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15371:5456
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004957
VERSION     KCXD01004957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15371:5456"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..523
     V_segment       142..434
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63439.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       449..468
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       481..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          113 a          131 c          154 g          127 t
ORIGIN      
        1 acatggggtc tgagagagga gccttagccc tggatttcaa ggcacttcca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggagg cttggtccag
      181 cctggagggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttacgac
      241 atgacctggg tccgccaggc tccgggaaag gggctggaat gggtctcata tattagttac
      301 actggtaaaa ccatatacta ctctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga actctctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtg
      421 tattattgtt ctagagcggc ttacgaacat gatgacggtt actattacgt cggcaggttt
      481 tttgactgct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01004958             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21212:16065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004958
VERSION     KCXD01004958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21212:16065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..405
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63440.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       421..428
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          111 a          114 c          137 g          126 t
ORIGIN      
        1 acatgggggg gattcccagg tgttttcatt cagagatcag gactgaacac acaggactca
       61 ccatggagtt tatgctgagc tgggttttcc ttgtttctat attaaaaggt gtccagtgtg
      121 tggagcatct ggtggagtct gggggaggct tggtacagcc tggggcgtcc ctgagactct
      181 cctgtgcagc ctctgaattc accttcagtg gctatgacat gcactgggtt cgccaggctc
      241 cagggaaggg tctagaatgg gtatcaggta ttaacattgg cggtgaccca tactacccag
      301 actctgtgaa gggtcgattc accatctcca gagacaacgc caagaactcc ttgtatcttc
      361 aaatgaacaa cctgagacct gaggacactg ctgtgtatta ttgtgtgagg gggatggata
      421 actaccactt cagtaatacg gactttgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01004959             359 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21889:12639
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004959
VERSION     KCXD01004959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 359)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21889:12639"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..357
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..357
     V_segment       8..286
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>326
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63441.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       299..307
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..357
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        358..>359
                     /gene="IGHG"
BASE COUNT           74 a          101 c          107 g           77 t
ORIGIN      
        1 acatggggga gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg
       61 ctgtctctgg tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga
      121 agggactgga gtggattggg tatatctatg ggagtgatag tagtaccaac tacaacccct
      181 ccctcaagag tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaagc
      241 tgagctctgt gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag
      301 tggttgccta cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004960             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15286:14189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004960
VERSION     KCXD01004960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15286:14189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..348
     V_segment       9..278
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <270..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63442.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       281..296
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           73 a           92 c          108 g           77 t
ORIGIN      
        1 acatgggggg gggcggcttg gcaaagcctg ggggatccct gagactctcc tgtgcagcct
       61 ctggattcac cttcagtacc tatgctatgc actgggtccg ccaggctcca gggaaggggc
      121 tggagtgggt ctcagccatt agtgttggtg gtagtacata ttacgcagac tccgtgaggg
      181 gccgattcac catctccaga gacaactcag agaacacgct ctccctgcaa atgaacagcc
      241 tgagagctga ggacacggcc gtgtattact gtgcgaaagg ggatacagct acagtttatt
      301 acggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004961             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20098:12355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004961
VERSION     KCXD01004961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20098:12355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..491
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63443.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          116 a          112 c          145 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtacaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaaat tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgcc aactctgtga agagccgatt caccatttcc agagacaatt
      361 ccaagagcat actatatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01004962             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10534:19689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004962
VERSION     KCXD01004962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10534:19689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..514
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63444.1"
                     /translation="CARNSYYYDIGYYYYGLDSW"
     D_segment       439..461
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          111 a          122 c          155 g          128 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gaggagtcag ggggaggctt ggtccagcct
      181 ggagggtccc tgagactctc ctgtgtagcc tcaggattca ccttcagtaa ttacgacatg
      241 agctgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatgt cagttacact
      301 ggtggaacca tatactacgc tgactccgtg aagggccggt tcaccgtctc tagagacgac
      361 gccaagaact cgctgtctct gcaaatgtgc agcctaagag ccgaggacac ggccgtgtat
      421 tactgtgcta gaaattccta ttactatgat attggttatt attattatgg tttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01004963             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21201:10323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004963
VERSION     KCXD01004963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21201:10323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63445.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          112 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004964             419 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13328:2803
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004964
VERSION     KCXD01004964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 419)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 419)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13328:2803"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    65..417
                     /note="immunoglobulin heavy chain variable region"
     V_region        65..417
     V_segment       65..356
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>386
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63446.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       360..372
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       376..417
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        418..>419
                     /gene="IGHG"
BASE COUNT           92 a           94 c          126 g          107 t
ORIGIN      
        1 acatggggaa gtttgggctg agctgggttt tccttgttgc tattttaaga ggtgtccagt
       61 gtgtggtgca gctggtggag tctgggggag gcttggttca gcctgggggg tccctgagac
      121 tctcctgtgc agcctctgga ttcaccttca gaacctttgg catgcattgg gtccgccagg
      181 ctccagggaa gggactggag tgggtggcag ttatatcgtc tgatggaggt tacaaatact
      241 acgcagactc taagaaggac cgattcacca tctccagaga caattccaag aacatcctat
      301 atcttcaact gaacaacctg aaattggagg acacggccgt gtattattgt gcgagagggg
      361 aatacagtaa ctctattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004965             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13616:5295
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004965
VERSION     KCXD01004965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13616:5295"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63447.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          111 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcggaacc tatggcatgc
      241 actgggtccg ccaggctcca gggatgggtc tggagtgggt gacggttata tcgaatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt cagcatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acgtgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcgttt ggtagcgggc ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004966             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:23059:2391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004966
VERSION     KCXD01004966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:23059:2391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63448.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          159 g          117 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaaggc ccgattcacc gtctccagag
      361 acaattccaa gaacatgtta tatcttcaaa cggacaacct gaaattggaa gacacggccg
      421 tgtattactg cgcgagagat gtctggggga ggggatttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004967             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13283:8832
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004967
VERSION     KCXD01004967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13283:8832"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..498
     V_segment       135..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63449.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       438..444
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          154 g          118 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 aaaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg aagctggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actctcctgc gcagcctctg gattcagctt caattattac tacatgagct
      241 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaat agtggtgggg
      301 aaagcacata ctctgcagac tccgtgaagg gcagattcac catctccaga gagaacgcca
      361 agaacacgct atatcttgaa atggacagcc tgagaactga ggacacggct gtctattatt
      421 gtgtgagaga tcgacgtgta cagtcgttat cctggttcga tgtctggggc ccgggagccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004968             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9980:8741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004968
VERSION     KCXD01004968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9980:8741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..489
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63450.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       433..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT           97 a          147 c          133 g          114 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aaaccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gcatatcagt gggagtagtg ggagcaccga ctacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaca gacacgtcca agagccactt ctccctgaaa ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga gctttccccc tacgactatt
      421 tttggagtga tttttactct tactactttg actacttggg ccagggactc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01004969             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12809:8451
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004969
VERSION     KCXD01004969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12809:8451"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63451.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          124 c          159 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01004970             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22195:2049
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004970
VERSION     KCXD01004970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22195:2049"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63452.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          119 a          139 c          134 g           96 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct gttgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac atcttaaccg aattatccat acactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atggggagtg ttgatcctca atatggtgag atgatagacg
      301 cagagaaatt ccagggcaga gtctccatga ccgaggacac gtctacagac acagcctaca
      361 tagagctgag cagtctgaga tctgaggaca cggccgtgta ttactgtgcg acatcatcca
      421 gcggcacctg gctatactgg tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01004971             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4847:9758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004971
VERSION     KCXD01004971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4847:9758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63453.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       440..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          115 a          122 c          161 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggtct gacctgggtt ttccttgttg
      121 gtcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggctc
      181 agcctggggg gtccctgaga ctctcctgtg cagcgtctgg gttcaccttc agtagctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gccatatcat
      301 ttgatggaag taagaaaaac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tgtactactg ttcgagggag tggatacagt gggcacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01004972             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5722:11470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004972
VERSION     KCXD01004972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5722:11470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63454.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       442..447
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          125 c          156 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgcccatt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctaagac tctcctgtgc agcctccgga ttcaccttca gtgaccactg
      241 catgcactgg gtccgccagg cttcagggaa ggggctggag tgggtctcag gtattactta
      301 taggggtgtt accacatggt acgcagactc cgtgaggggc agattcacca tctccagaga
      361 gaacgccaag aacacattgt attttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgacaggac ggcggcacgt ggaccttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01004973             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7924:14610
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004973
VERSION     KCXD01004973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7924:14610"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63455.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       403..418
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          135 c          130 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcacc aatagttact ggaactggat ccgccagccc ccaggaaagg ggctggagtg
      241 gattgggtct atctatggtg gtactgggag caccggctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga cctctgtgac
      361 cgccgcggac accgccgttt attattgtgc gagatatgag gatgaataca gtgactacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004974             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:22986:12167
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004974
VERSION     KCXD01004974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:22986:12167"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63456.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       443..448
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          125 c          156 g          114 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cacaccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccat tgtgaggtgc agctggtgga atctgggggc ggcttggcaa
      181 agcctggggg gtccctaaga ctctcctgtg cagcatccgg attcaccttc agtgaccact
      241 gcatgcactg ggtccgccag gcttcaggga aggggctgga gtgggtctca ggtattactt
      301 atgctggtgt taccacatgg tacgcagact ccgtgagggg cagattcacc atatccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagacctgag gacacggctg
      421 tctattactg tgtgggagga aggcggcacg tggaccttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004975             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8165:10437
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004975
VERSION     KCXD01004975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8165:10437"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63457.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          115 a          144 c          129 g           93 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttccg gatacacctt aaccgaccac tacctacact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtattctt cctgagtatg gtaaagttga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01004976             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:13960:15777
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004976
VERSION     KCXD01004976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:13960:15777"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63458.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       403..413
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          140 c          135 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactgctgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaacta ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac gtatctctgg tagtggtggg aacaccgtct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagatct ccctgaaagt gacctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgacagccg gatatagcag cagggaaagc
      421 ttctacggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01004977             436 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:4388:5900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004977
VERSION     KCXD01004977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:4388:5900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..434
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..434
     V_segment       71..364
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <356..>403
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63459.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       368..375
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..434
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        435..>436
                     /gene="IGHG"
BASE COUNT           88 a          125 c          123 g          100 t
ORIGIN      
        1 acatgggaag aacatgaagc acctgtggtt cttccttctc ctggtggcag ctcccagatg
       61 ggtcctgtcc caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac
      121 cctgtccctc acctgcggtg tctctggtga ctccatcagt agtagctact ggaactggat
      181 ccgccagccc ccggggaagg gactggagtg gattgggtat atctctggtg cttatgggag
      241 caccagctac aatccctccc tcaagagtcg agtcaccatt tcaacagaca cgtccaagaa
      301 ccagttttcc ctgaggctga gttctgtgac cgccgcggac accgccgtgt attactgtgt
      361 gagatatgag gatgagtcca ttaactacca ctttgactac tggggccagg gagtcctggt
      421 caccgtctcc tcagcc
//
LOCUS       KCXD01004978             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16601:9917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004978
VERSION     KCXD01004978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16601:9917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..448
     V_segment       103..389
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63460.1"
                     /translation="CASSDYGWFDVW"
     D_segment       394..402
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           93 a          123 c          127 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggaa
      121 tcggacccag gagtagtgaa gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 ggcgatagtt ataggtggag ctggatccgc cagcccccag ggaagggact ggaatggatt
      241 gggtatattt atggtagtat tacggacacc aactacaacc cctccctcaa aagtcgagtc
      301 accatttcaa aagacacgtc caagaagcag ttctccttga aactgagctc tgtgaccgtc
      361 gcggacacgg ccgtgtattt ctgtgcgagt tcagactacg gttggttcga tgtctggggc
      421 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01004979             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20808:17913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004979
VERSION     KCXD01004979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20808:17913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..485
     V_segment       125..418
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63461.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       428..437
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          100 a          145 c          134 g          108 t
ORIGIN      
        1 acatgggggg agtctccctc accgcacagc tgggatctca gtgcttcctt ttctgtcctc
       61 caccacgatg gggtcaactg ccatcctcac cctcctactg gctgttctcc aaggagtctg
      121 tgccgaggtg cagctggtgc agtctggagc agaggtgaaa aggcccgggg agtctctgaa
      181 gatctcctgt aagacttctg gatacagctt taccagctac tggatcacct gggtgcgcca
      241 gatgcccggg aaaggcctgg agtggatggg ggcgattgat cctagtgatt ctgctaccaa
      301 atacagcccg tccttccaag gccaggtcac catttcagcc gacaagtcca tcaccaccgc
      361 ctacctggag tggaacagcc tgaaggcctc ggacaccgcc acgtattact gtgcgaaagg
      421 tcccggagtg attattaact actttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01004980             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15682:20225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004980
VERSION     KCXD01004980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15682:20225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63462.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       265..270
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..320
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           71 a           79 c           97 g           75 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtatctc
       61 tggcatgcac tgggtccgcc aggctccagg gcaggggctg gaatgggtgg cagttgaatc
      121 gtttgatgga ggtaagaaat actacgctga ctctgtgaag gaccgattca ccatctccag
      181 agacaattcc aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtgtattac tgtgtgagag atgcctacgg gggcggtttg gattcctggg gccaaggggt
      301 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01004981             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10866:5421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004981
VERSION     KCXD01004981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10866:5421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63463.1"
                     /translation="CARDPQWQLELLHFDYW"
     D_segment       408..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          139 c          135 g          105 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggtctggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcaatttct actggaactg gatccgccag cccccaggga gggggctgga
      241 gtggattggc tatatcagtg gtggtagtgg gaacaccgag tacaacccct ccctcaagag
      301 tcgagtcacg atttcaacag acacgtccaa gaaacagttc tctctgaagt tgaattctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagac ccccaatggc agctggaact
      421 cctccacttt gactactggg gccagggagt cctggttacc gtctcctcag cc
//
LOCUS       KCXD01004982             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7727:18100
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004982
VERSION     KCXD01004982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7727:18100"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63464.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       436..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          106 a          124 c          158 g          116 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggggata gcacatacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgtc tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01004983             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:4601:15081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004983
VERSION     KCXD01004983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:4601:15081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63465.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       403..418
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          140 c          133 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggctg ctcccagatg ggtcctgtcc cagctgcatc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtct atctatggtg gtactgggag cgccggctac aacccctccc tcaagagtcg
      301 agtcaccgtt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga cgtctgcgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgag gatgaataca gtgactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004984             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15728:9469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004984
VERSION     KCXD01004984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15728:9469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63466.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          118 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggccgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccatag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01004985             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24806:22171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004985
VERSION     KCXD01004985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24806:22171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63467.1"
                     /translation="CVRDSSGSGFDYW"
     D_segment       441..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          112 c          148 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acttctggca
      241 tacactgggt ccgcctggct ccagggaagg ggctggagtg ggtggcagtt atatcgtacg
      301 atgaaaataa gaaatactat acagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaaaaa catggtatat cttcacatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgt gagagattca agcggttcgg gatttgacta ttggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01004986             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:24074:11763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004986
VERSION     KCXD01004986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:24074:11763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63468.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          133 c          137 g           97 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgatg tctctggggg
      181 ctccatcagc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtatctacg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgaggtctat
      361 gaccgccgcg gacgcggccg tgtattactg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01004987             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16337:14884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004987
VERSION     KCXD01004987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16337:14884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..492
     V_segment       111..403
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63469.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       418..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          124 c          145 g          119 t
ORIGIN      
        1 acatgggaag gcacttccac ctggggatca gcactgaaca cagaggaccc accatggagt
       61 tggggctgag ctgggttttc cttgttgcta ttttaaaagg tgtccagtgt gaggtgcaac
      121 tggtggagtc tgggggaggc ttggtccagc ctggagggtc cctgagactc tcctgtgcag
      181 cctctggatt caccttcagt agttacgaca tgacctgggt ccgccaggct ccgggaaagg
      241 ggctggagtg ggtctcatat attagttaca ctggtaaaac catatactac tctgactccg
      301 tgaagggccg attcaccatc tccagagaca acgccaagaa ctctctgtct ctgcaaatga
      361 gcagcctgag agccgaggac acggccgtgt attattgttc tagagcggct tacgaacatg
      421 atgacggtta ctattacgtc ggcaggtttt ttgactgctg gggccaggga gccctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01004988             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23603:9450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004988
VERSION     KCXD01004988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23603:9450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..289
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <288..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63470.1"
                     /translation="CTTEQPHLERFDYW"
     D_segment       297..303
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       317..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           88 a           94 c          102 g           78 t
ORIGIN      
        1 acatgggggt ggagtctggg ggaggcctgg tccagcttgg cgggtccctg agactctcct
       61 gtgcagcctc tggattcacc ttcagtaacc atgccatgag ctgggtccgc caggcttctg
      121 ggaaaggact ggagtgggtt ggctatatta gaggcaaata taacaattac gcgacagaat
      181 acgccgcatc ggtgaaaggc agattcacca tttccagaga tgattcaaag aacacactat
      241 atctgcagat gagcagcctg aaaaccgagg acacggccct gtattattgc accacagaac
      301 aaccccattt ggagcgcttt gactactggg gcctgggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01004989             348 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9777:3060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004989
VERSION     KCXD01004989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 348)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 348)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9777:3060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..346
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..346
     V_segment       7..279
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>315
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63471.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       286..293
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..346
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        347..>348
                     /gene="IGHG"
BASE COUNT           75 a           88 c          107 g           78 t
ORIGIN      
        1 acatgggggg gcggcttggt aaagcctggg gggtccctga gactctcctg cgcagcctct
       61 ggattcagct tcagttattt ctacatgagc tgggtccgtc aggctccagg gaaggggctg
      121 gagtggatct caagtattga cagtggtggg actaccacaa attatgcaga ctccgtgagg
      181 ggcagcttca ccatctccag agagaacgcc aagaacacac tgtatcttca aatggacagc
      241 ctgagagctg aggacacggc tgtctattat tgtgcgagag cgcgcggggt gatcattaca
      301 tactttgact cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004990             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19364:20088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004990
VERSION     KCXD01004990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19364:20088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..455
     V_segment       103..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63472.1"
                     /translation="CASPLLPATGNW"
     D_segment       414..421
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>459
                     /gene="IGHG"
BASE COUNT           87 a          133 c          132 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtga tgtctctggt
      181 cactccatca atagtggtta ctcctggggc tggatccgtc agcccccagg gaagggactg
      241 gagtggattg ggtttatcgg tggtcgtagt gggtacacct actacaaccc ctccctcagg
      301 agtcgagtca gcatctcaaa agacacgtcc aagaaccagt tctccctgga agtgaattct
      361 ctgagcgccg cggacacggc cgtgtattat tgtgcgagtc ctctccttcc ggcaactgga
      421 aactggggcc agggagtcct ggtcatcgtc tcctctgcc
//
LOCUS       KCXD01004991             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12651:19557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004991
VERSION     KCXD01004991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12651:19557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..504
     V_segment       123..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63473.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       425..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          142 c          145 g          104 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gttggtgcag tccggggctg aggtgaagag gcctggggcc tcagtgaagc
      181 tctcctgcaa ggctcctgga tacatcttca gcatatctgc catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag ggatcatccc tcttgttggt gtaacaacct
      301 acgcacagaa cttccaggac agagtcacga ttaccgcgga cacgtccaca agcacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtatttctgt gcgagtggcg
      421 gcttcgagga tgataacggt cactattata cgacactaac atttcacgag tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01004992             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4505:11364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004992
VERSION     KCXD01004992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4505:11364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63474.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       429..439
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          114 a          141 c          144 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga cacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggctgggag gtgttgatct tgtatatgat gaaataatac
      301 acgcagagaa gttccaaggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattactgt gcggcgggcc
      421 ttgggggata tttactgctc actgaatacc tcgagttctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01004993             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11113:8350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004993
VERSION     KCXD01004993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11113:8350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63475.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          111 c          151 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct atggcattca
      241 ctgggtccgc cagactccag ggaaggggct ggagtgggtg gcagttatat cgtatgatga
      301 aactaagaca tactacgcag actctgtgag ggaccgattc accatctcca gagacaattc
      361 caaaaacatg gtgtattttc aaatgaacaa cctgaaattg gaggacacgg ccgtatatta
      421 ctgtgtgaga gatgtcaggg gaacggggtt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01004994             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23008:7982
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004994
VERSION     KCXD01004994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23008:7982"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..283
     V_segment       8..210
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <202..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63476.1"
                     /translation="CARYDEDDYGYYYLDYW"
     D_segment       215..240
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       242..283
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           59 a           83 c           76 g           67 t
ORIGIN      
        1 acatggggta gcttctggaa ctggatccgc cagcccccag gaaaggggct gcagtggatt
       61 gggtctatct ctggtgctac tgggactacg ggctacgacc cctccctcaa gagtcgagtc
      121 accatttcaa ctgacacgtc caagaaccag ttttccctga agctgaactc tgtgaccgcc
      181 gcggacaccg ccgtttatta ctgtgcgaga tatgacgagg atgattacgg ttattattac
      241 cttgactact ggggcccggg actcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004995             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22047:12938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004995
VERSION     KCXD01004995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22047:12938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63477.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       403..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           91 a          138 c          137 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctccatcagc agtagtacct ggtggaactg ggtccgccag cccccaggga aaggcctgga
      241 gtggatagga tatatcaatg gtgagagtgg tagcacctac tacaatccct ccctcgagag
      301 tcgaatcacc atttcaacag acacgtccac gaaccagttt tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagaggt tcctatagtg gtagttatta
      421 cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01004996             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20161:8947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004996
VERSION     KCXD01004996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20161:8947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63478.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       413..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          107 a          137 c          143 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgattt gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgaatat ggtgaaatga
      301 cgttccaggg gagagtcacc atgaccgagg acacgtctac agacacggcc tacatggagc
      361 tgagtagcct gagatctgag gacacgggcg tgtattactg tgcgattggc cctagcggca
      421 ggtggaacca ctggtccttc gagatctggg gacctgggac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01004997             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:3804:6219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004997
VERSION     KCXD01004997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:3804:6219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63479.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       414..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          146 c          136 g           89 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccctc accgaagtgt ccactcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctaa gatctgagga cacggccgtg tattactgtg cgattggccc taccggcagg
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01004998             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17480:18633
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004998
VERSION     KCXD01004998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17480:18633"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63480.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          137 c          128 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggtccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccaggcaa gggactggag
      241 tggattggat atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcgacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01004999             302 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:23113:13842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01004999
VERSION     KCXD01004999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 302)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 302)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:23113:13842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..300
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..300
     V_segment       8..213
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <207..>269
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63481.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       232..242
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..300
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        301..>302
                     /gene="IGHG"
BASE COUNT           73 a           80 c           86 g           63 t
ORIGIN      
        1 acatgggcac cgaattatcc atgcactggg tgcgacaggc ccctggacaa gggcttgagt
       61 ggatgggact tgttgatcct gtaaatggtg aactaataca cgcagacaac ttccagggca
      121 gagtcaccat gaccgaagac acgtctacag acacagccta catggagttg agcagcctga
      181 catctgagga cacggccatc tactactgtg cgacagggag gatcggtacc agtggctggt
      241 ccaacctctt caatggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcttcag
      301 cc
//
LOCUS       KCXD01005000             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11711:20436
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005000
VERSION     KCXD01005000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11711:20436"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63482.1"
                     /translation="CARDVYGCGLDYW"
     D_segment       441..446
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          113 c          153 g          121 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtccacctg gtggaatctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattcg ccttcagtag gtttggcatg
      241 cactgggtcc gccagactcc aggaaagggg ctggagtggg tggcagttat gtcgtctgat
      301 ggaagtagga tatactacgc agactctttg aaagaccgat tcaccatatc cagagacaat
      361 tccaagaaca tgctatatct tcaactgaac aacctgaaat tggaggacgc ggccgtgtat
      421 tactgtgcga gagatgtcta tggctgtggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcgt cagcc
//
LOCUS       KCXD01005001             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9854:13423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005001
VERSION     KCXD01005001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9854:13423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63483.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       413..425
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          108 a           99 c          143 g          117 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc cctgagactc tcctgtgcag
      181 cttcggggtt catcttcagt agttatggca tgcactgggt ccgcctggct ccagggaagg
      241 ggctggagtg ggtggcagta acatcgtctg atgaaagtaa gaaattctac ggagactctg
      301 tgaaggaccg attcaccatc tccagagaca attcccagaa catactatat tttcaaatga
      361 acaacctgaa attgaaggac acggccgtct actattgtgg gagagatgat aatggggtga
      421 ttattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005002             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15249:8658
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005002
VERSION     KCXD01005002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15249:8658"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63484.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       447..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          118 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga actttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttaaatcgt
      301 ttgatggaac caagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcctacggga gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005003             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11664:15885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005003
VERSION     KCXD01005003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11664:15885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..439
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63485.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       450..464
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          108 a          124 c          154 g          128 t
ORIGIN      
        1 acatgggggc tctaggagag gagcccagcc ctgggattcc caggtgtttt catttgtgat
       61 cagcactgaa cacagaagac tcatcatgga gtttggcctg agctgggttt tccttgttgc
      121 tattttaaaa ggtgtccagg gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactactg
      241 gatgtactgg gttcgccaga cacctgagca ggggctggag tggatctcag ctattgatag
      301 tgctgctact agtaccacat actatgcaga ctccgtgaag ggcagattca ccatctccag
      361 agagaacgcc aaaaacacac tgtatcttca gatggacagc ctgagaactg aggacacggc
      421 tgtctattac tgtgcgagag ttccgggcct agtggtattt actggttcgc ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005004             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5409:10706
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005004
VERSION     KCXD01005004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5409:10706"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63486.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       424..431
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          138 c          151 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgaccct gcaaatggtg aaataataca
      301 cgcagatagt ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagaggggg
      421 gttcggtagc agtgtctggt ccaatctcgt ctatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005005             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8899:16231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005005
VERSION     KCXD01005005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8899:16231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63487.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          114 a          124 c          149 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gccccgggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtatct ggttatttta cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01005006             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:6376:16621
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005006
VERSION     KCXD01005006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:6376:16621"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63488.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       421..428
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          141 c          150 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccgctctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga cttatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgaccctgca aatggtgaaa taatacacgc
      301 agatagtttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc ggcctgcgat ctgaggacac ggccgtttat tactgtgcga gagggggctt
      421 cggtagcagt gtctggtcca atctcgtcta tggtttggat tcctggggcc aaggggtcgc
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005007             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12095:18025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005007
VERSION     KCXD01005007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12095:18025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63489.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       427..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          110 a          139 c          145 g          100 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg cagtgaagag gcctggggcc tcagttaagg
      181 tctcctgcaa ggtttccgga tactccttca ctgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtgtatggt gaagaaatac
      301 acgcagagaa tttccaggac agagtcacca tgaccgagga cacgtccaca gacacagcct
      361 acatggagct gagcagcctg agacgtgagg acacggccgt gtatttctgt gcggcgggcc
      421 ttggggggta tttagttctt actgaatacc tcgaattctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01005008             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12863:7790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005008
VERSION     KCXD01005008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12863:7790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63490.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       416..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          139 c          145 g          108 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtctca
      121 ggtccagctg gtgcagtccg gggctgagat ggagaagcct ggggcctcag tgaagctctc
      181 ctgtaaggct tctggataca ccttcagcat ctatgtcatc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggaggcat cttccctctt gttggtacaa caaactacgc
      301 acagaagttc cagggcagag tcacgattac cgcggacacg tccacaagca cagcctacat
      361 ggacctgagc agcctgggat ctggggacac ggccgtgtat tattgtgcga gaggttactg
      421 tactggtagt ggttgtaacc ttacattcaa ccggctcgat gtctggggcc cgggagtccc
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005009             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19014:16429
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005009
VERSION     KCXD01005009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19014:16429"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63491.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       412..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          115 a          142 c          128 g           89 t
ORIGIN      
        1 acatgggaca caaccaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggct cctcctcttg gtggcagcag ctacaggcgc ccactccgag
      121 gtccagctgg tacagtctgg ggctgaggtg aagaagcctg gggcctccgt gaaaatctcc
      181 tgccaggctt ctggatacac cttaaccgac cactacctgc actgggtgcg acaggctcct
      241 ggaaaaggac ttgagtggat gggaggtgtt catcctgaat atgggaaagt agactacaca
      301 cagaagttcc aagacagagt caccatcacc gcggacatgt cgacagagac agtctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccacttatt actgtgtgac agtgggtccc
      421 taccattact ttgactactg gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005010             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18576:16095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005010
VERSION     KCXD01005010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18576:16095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..282
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..282
     V_segment       8..206
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <198..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63492.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       208..214
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       241..282
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        283..>284
                     /gene="IGHG"
BASE COUNT           64 a           69 c           91 g           60 t
ORIGIN      
        1 acatgggatc catgcactgg gtgcgacagg cccctggaaa agggcttgag tggatgggag
       61 gtgttgatac tgtatctgat ggagtgatat acgcagagaa cttccagggc agagtcacca
      121 tgaccgagga cacgtctaca gacacagcct acatggagct gagcagcctg agatctgagg
      181 acacggccgt ttattactgt gcgagaggtg tgacagcaga cgtcttcggt ttcctcgggc
      241 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005011             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9809:11108
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005011
VERSION     KCXD01005011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9809:11108"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63493.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          113 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gcgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag aatatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atttgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005012             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:4933:9028
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005012
VERSION     KCXD01005012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:4933:9028"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63494.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       425..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          114 a          144 c          141 g           95 t
ORIGIN      
        1 acatggggga acatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaaccctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgagtt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt cagtggatgg gaagtgttga tcctgcatat ggtgaaatga
      301 taaacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgtcatctg aggacacggc cgtgtatttc tgtgcgagtg
      421 gccctagcgg cagctggaac ggctggtact tcgatttctg gggccctggc actccaatca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01005013             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:11110:7444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005013
VERSION     KCXD01005013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:11110:7444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63495.1"
                     /translation="CASNLRGNTFSYWRSFDFW"
     D_segment       449..455
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          108 a          133 c          157 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtggt agtaaatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg acacctgagg acacggccgt
      421 ttattactgt gcgtcgaacc tacgtggaaa caccttcagt tactggcggt cctttgactt
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005014             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23768:11650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005014
VERSION     KCXD01005014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23768:11650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63496.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       446..451
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          109 a          113 c          154 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctatgttaag aggtgtccag tgtgaggtgc agatggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctttg
      241 gcatccactg ggtccgccag gctccaggga aggtgctgga gtgggtggca gttatttcat
      301 atgatgaaat tacgaaatac tacgcagact ctgcgaagga ccgattcacc atctccagag
      361 acaattccaa gaatgtggta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      421 tgtatttctg tgcgagaggg gattttggta atggcgtcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01005015             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10742:11542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005015
VERSION     KCXD01005015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10742:11542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63497.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          114 c          152 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggttca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005016             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15483:4533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005016
VERSION     KCXD01005016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15483:4533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63498.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          146 c          132 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcccgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgac cctgcatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatctga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005017             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:23097:18495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005017
VERSION     KCXD01005017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:23097:18495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63499.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          114 a          119 c          145 g          130 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg gattcccagg tgctttcatc cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg tggagcagct ggtggaatct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagtt cctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctggagtgg gtttccggta ttaacattgg
      301 cggtgacaca tactacccag actctgtgaa gggtcgattc actatctcca gagacaatgc
      361 caagaactcc ttgtatcttc aaatgaacag cctgagagtt gaggacactg ctgtgtattt
      421 ttgtacaagg gggatagata actaccactt tagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005018             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20764:12026
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005018
VERSION     KCXD01005018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20764:12026"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..501
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63500.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>505
                     /gene="IGHG"
BASE COUNT          119 a          142 c          144 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctgggg cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 acacgcagag aaattccagg gcagagtcac tatgaccgag gacacgtcta cagacacagc
      361 cttcatggag ttgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaacct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct ctgcc
//
LOCUS       KCXD01005019             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14286:17379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005019
VERSION     KCXD01005019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14286:17379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63501.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          110 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtga agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtctctgaga ctctcctgtg cagcttccgg attcaccttc agtttctatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcga
      301 atgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005020             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15188:10616
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005020
VERSION     KCXD01005020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15188:10616"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63502.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          114 a          142 c          131 g           92 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggt aaagtagact
      301 acacacagaa gttccgagac agagtcacca tcaccgcgga catgtcgaca gagacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac tactggggcc agggagccct ggtcaccgtt tcctcagcc
//
LOCUS       KCXD01005021             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13961:5710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005021
VERSION     KCXD01005021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13961:5710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63503.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          119 c          154 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cggccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttatatcg
      301 tctgatgaaa gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaagttgga ggacacggcc
      421 gtctattact gtgcgagaga cgcatatggc agcggctgtg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005022             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:16206:21799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005022
VERSION     KCXD01005022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:16206:21799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63504.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          116 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggccgg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagt tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaagtt ggaggacacg gccgtctatt
      421 actgtgcgag agacgcatat ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005023             434 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13025:17935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005023
VERSION     KCXD01005023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13025:17935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    66..432
                     /note="immunoglobulin heavy chain variable region"
     V_region        66..432
     V_segment       66..357
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <351..>401
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63505.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       371..377
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       381..432
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        433..>434
                     /gene="IGHG"
BASE COUNT          103 a          114 c          127 g           90 t
ORIGIN      
        1 acatgggcat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
       61 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      121 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      181 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      241 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      301 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      361 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      421 ccatctcctc agcc
//
LOCUS       KCXD01005024             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:26966:14193
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005024
VERSION     KCXD01005024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:26966:14193"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..458
     V_segment       83..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63506.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       387..403
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..458
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           98 a          141 c          117 g          104 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgca
      121 acccacacag accctcacgc tgacctgcac cttctctggg ttctcaatca gtacttctgc
      181 aacaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaagcat
      241 ttattggaat gatactaaat tcttcagcac ttcgctgaag agcagactca ccgtctccaa
      301 ggacacctcc aaaacccagg tggttctaac aatagccaac atggaccctg tggacacagc
      361 cacatattac tgtgcacgga tacagggtgg tagttactac tacggtgggg gatacttcga
      421 gttctggggc cagggcgccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005025             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5657:14812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005025
VERSION     KCXD01005025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5657:14812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63507.1"
                     /translation="CTGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          131 c          156 g          106 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctact
      241 ggatgaactg ggtccgccag gctccaggaa agggactgga gtgggtctca gctattaata
      301 gtgatgggga gaacacatac ttcgcagact ccgtgaaggg ccgattctcc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct gagaccggag gacacggccg
      421 tgtattactg cacgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005026             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20240:10002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005026
VERSION     KCXD01005026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20240:10002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63508.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          116 c          152 g          119 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agttcgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taagaaatac tacgcaaact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatactc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatatgggga ccggttttga ctactggggc cagggagtcc
      481 tggtcatcgt ctcctcagcc
//
LOCUS       KCXD01005027             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4390:19289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005027
VERSION     KCXD01005027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4390:19289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63509.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       441..445
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          137 c          142 g          102 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatact gtatctgatg gagtgatata
      301 cgcagagaac ttccagggca gagtcgccat gaccgaggac acgtctacag acacagccta
      361 catggaattg agcagcctga gatctgagga cacggccgtt tattactgtg cgagaggttt
      421 atcaccagac gtcttcggtt tcctcgggct tggctactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005028             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:28525:11968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005028
VERSION     KCXD01005028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:28525:11968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63510.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       453..467
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          115 a          127 c          147 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgacta
      241 tgccctgagc tgggtccgcc aggcttctgg gaaaggactg gagtggattg gctatattag
      301 aagccaatat aacaatttcg cgacagaata cgccccatcg gtgaaaggca gattcaccat
      361 ctccagagat gattcacaga acacgctatt tctgcaaatg agtagcctga aaaccgagga
      421 cacggccgtg tattactgca ccacccattt tggtggtaat tattacttgg actactttgt
      481 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005029             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18686:4297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005029
VERSION     KCXD01005029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18686:4297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63511.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       397..404
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           92 a          138 c          127 g          108 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagca gtagctactg gaactggatc cgccagcccc cagggaaggg actggagtgg
      241 attggctata tctctggtgc ttatgggagc accagctaca acccctccct caagagtcga
      301 gtcaccattt caactgacac gtccaagaac cagttttccc tgaggctgag ttctgtgacc
      361 gccgcggaca ccgccgtgta ttactgtgtg agatatgagg atgaatccat taactaccac
      421 tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005030             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14162:8453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005030
VERSION     KCXD01005030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14162:8453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63512.1"
                     /translation="CARGDIGNGVDYW"
     D_segment       434..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          108 a          113 c          152 g          121 t
ORIGIN      
        1 acatgggggt gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatgt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tttggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtatgatg
      301 aaattacgaa atactacgca gactctgcga aggaccgatt caccatctcc agagacaatt
      361 ccaagaatat ggtatatctt caaatgaaca gcctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgccag aggggatatt ggtaatggcg tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc tgcc
//
LOCUS       KCXD01005031             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:15992:13871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005031
VERSION     KCXD01005031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:15992:13871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63513.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          137 c          137 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcac tgtctctggt
      181 ggctccttca gtggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ttatcggtgg tggtagtggg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtccaag aatcaattct ccctgaagct gacctctatg
      361 gccgccgcgg acacggccgt ttatttctgt gccagagatg cgggagtggg agccacaatc
      421 ctttactact atgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005032             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11580:12523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005032
VERSION     KCXD01005032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11580:12523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63514.1"
                     /translation="CARYEGAAAGTWFFDYW"
     D_segment       406..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          140 c          133 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca ccaatcatta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tgggttgggt ctctctatgg tgctactggg agcaccaact ataatccctc cctcaagagt
      301 cgagtcagca tttcaacaga catgtccaag aaccagtttt ccctgaaact gacctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg agggggcggc agctggaacc
      421 tggttctttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005033             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12678:14757
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005033
VERSION     KCXD01005033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12678:14757"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63515.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggttc agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005034             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:19637:11690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005034
VERSION     KCXD01005034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:19637:11690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63516.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       420..429
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          118 a          138 c          134 g          107 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg caaggcttct ggattcacct tcgacaacta tggtatcaac tgggtgcgac
      241 aggcccctgg acaggggctt gagtggatgg gagtaaccat cccccttgtt ggtataatca
      301 actacagaga caacgtccag gacagagtca ccatttccgc ggacacgtcc acaaacacag
      361 cctacatgga gataaacagc ctgagatctg acgacacggc catctattac tgtgcgagag
      421 aatattgtac ttctactgat tgcgccggat tttttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005035             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15734:9521
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005035
VERSION     KCXD01005035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15734:9521"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63517.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          152 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc ctttcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gaactgggtt ttccttgtta
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatttttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaag taaaaaatac tactcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccga ggccagtgtc tatcttcaaa tgaataacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcgtatggtt ccggcttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005036             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16379:2707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005036
VERSION     KCXD01005036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16379:2707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63518.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          140 c          135 g           94 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa agtccaaggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcgt
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcgtcagc c
//
LOCUS       KCXD01005037             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22998:10281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005037
VERSION     KCXD01005037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22998:10281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63519.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          134 c          133 g          109 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tgactccatc agtagtagct actggaactg gatccgccag cccccgggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgagt ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005038             353 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14673:14465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005038
VERSION     KCXD01005038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 353)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 353)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14673:14465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..351
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..351
     V_segment       8..290
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63520.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       292..296
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       305..351
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        352..>353
                     /gene="IGHG"
BASE COUNT           76 a           81 c          110 g           86 t
ORIGIN      
        1 acatgggggt ggagtctgga ggaggcttgg ttcagcctgg ggggtccctg agactctcct
       61 gtgcagcctc tggattcacc ttcagtatat ctggcatgca ctgggtccgc caggctccag
      121 ggaaggggct ggagtgggtg tcagttatat cgtctgatgg aagtaagaaa tactacgcag
      181 actctgtgaa ggaccgattc accatctcca gagacaattc aaaaaacatg gtttatcttc
      241 aaatgaacaa cctgaagttg gaggacacgg ccgtgtattt ctgtgtgaga gatgccttcg
      301 ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005039             390 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14746:11549
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005039
VERSION     KCXD01005039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 390)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 390)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14746:11549"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    168..388
                     /note="immunoglobulin heavy chain variable region"
     V_region        168..388
     V_segment       168..327
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <319..>357
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63521.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       337..342
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       346..388
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        389..>390
                     /gene="IGHG"
BASE COUNT           97 a           82 c          118 g           93 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gtgggtggca
      181 gttatatcgt atgatgaaac taagacatac tacgcagact ctgtgaggga ccgattcacc
      241 atctccagag acaattccaa aaacatggtg tattttcaaa tgaacaacct gaaattggag
      301 gacacggccg tatattactg tgtgcgagat gtcaggggaa cggggtttga ctactggggc
      361 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005040             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13454:7282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005040
VERSION     KCXD01005040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13454:7282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63522.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       411..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          137 c          145 g          108 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggtt gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt tactgtactg
      421 gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005041             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22395:10440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005041
VERSION     KCXD01005041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22395:10440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..515
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63523.1"
                     /translation="CVRDIPYYNFWSGYDSGLDAW"
     D_segment       439..463
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          110 a          122 c          157 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc cggattcatc ttcagtgacc actacatgga
      241 ctgggtccgc caggctccag ggaaggggct ggaatgggtc tcacgtgtta ctaatgatgg
      301 tggtagcaca tggtacgcag actccgtgaa ggacagattc accatctcca gagagaacgc
      361 cgagaacacc ctttatcttc aaatgaaaag cctgagagct gaggacacgg ctgtctattt
      421 ttgtgtgaga gatattccgt attacaattt ttggagtggt tatgactccg gtttggatgc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005042             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17318:12760
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005042
VERSION     KCXD01005042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17318:12760"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63524.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       447..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          158 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggcgg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cggaacctat
      241 ggcatgcact gggtccgcca ggctccaggg aagggcctgg agtgggtgac ggttatatcg
      301 aatgatggaa gtaagaaata ctacgcggac tctgtgaagg accgattcag catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacg tgaaattgga ggacacggcc
      421 gtctattact gtgtgagaga tgcgtttggt agcgggcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005043             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8297:16929
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005043
VERSION     KCXD01005043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8297:16929"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63525.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          144 c          144 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggct tggattcttg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005044             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6580:7226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005044
VERSION     KCXD01005044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6580:7226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63526.1"
                     /translation="CARGSNVWVPDSDYW"
     D_segment       429..436
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          117 a          134 c          144 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagcgtc accgaattat gcatacactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgtaaatga ggcaataata
      301 gacgctgaga acttccaggg cagactcacc atgaccgagg acacgtctac tgacacagcc
      361 tacatggagc tgaggagcct gagatctgag gacacggccg tgtattattg tgccagaggg
      421 agcaacgtgt gggtaccgga ctctgactac tggggccagg gagtcctggt caccgtctct
      481 tcagcc
//
LOCUS       KCXD01005045             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:7090:14071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005045
VERSION     KCXD01005045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:7090:14071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63527.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       413..424
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          110 a          100 c          142 g          115 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgaa ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagt
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc cctgagactc tcctgtgcag
      181 cttctggatt caccttcagt agttatggca tgcactgggt ccgcctggct ccagggaagg
      241 ggctggagtg ggtggcagtt acatcgtctg atgaaagtaa gaaatactac ggagactctg
      301 tgaaggaccg attcaccatc tccagagaca attccaagaa catactatat cttcaaatga
      361 acaacctgaa attggaggac acggccgtgt actactgtgg gagagatgat aatggggtga
      421 ttatcgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005046             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9165:15168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005046
VERSION     KCXD01005046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9165:15168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63528.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       439..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          115 c          158 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acgcagactc tgtgaaggcc cgattcaccg tctccagaga
      361 caattccaag aacatgttat atcttcaaac ggacaacctg aaattggaag acacggccgt
      421 gtattactgc gcgagagatg tctgggggag gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005047             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19652:13999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005047
VERSION     KCXD01005047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19652:13999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63529.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       428..434
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          139 c          152 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgcaaatgg tgaaataata
      301 cacgcagatg gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgggcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 aggttcggta gtagcgtctg gtccaatctc gtctatggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005048             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22781:10812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005048
VERSION     KCXD01005048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22781:10812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..500
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63530.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          118 a          142 c          144 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcact atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc tgcc
//
LOCUS       KCXD01005049             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22878:20014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005049
VERSION     KCXD01005049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22878:20014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63531.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          119 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atggctgaca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005050             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20267:9827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005050
VERSION     KCXD01005050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20267:9827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63532.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          143 c          134 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccaa ctgatacagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaga ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagtctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcacc tggctatatt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005051             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12168:10523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005051
VERSION     KCXD01005051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12168:10523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63533.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       444..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          117 c          154 g          117 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccactg tgaagtgcag ctggtggagt ctggaggagg cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgca gtctctgggt tcaccttcag tggctctggc
      241 atgcactggg tccgccaggc tccagggaag gggctggaat gggtggcggt tatatcgaat
      301 gatggaacta acaaatacta cgcagactct ctgaaggacc gatttagtat ctccagagag
      361 aattccaaga acatgctata tcttcaaatg aacaacctga aactggagga cacggccgtc
      421 tattactgcg cgacagatgc gtttggtagc gggattgact actggggccg gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005052             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21161:12417
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005052
VERSION     KCXD01005052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21161:12417"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63534.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       423..432
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          121 a          141 c          126 g          101 t
ORIGIN      
        1 acatgggagc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat ccctgcactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agttttaatc ctatttatgg tgaaatttta
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagaagcct gatatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt atccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01005053             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23136:6636
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005053
VERSION     KCXD01005053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23136:6636"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63535.1"
                     /translation="CAREYCTSDACAGFFDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          112 a          133 c          138 g          102 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 acttggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg attcaccctc gacaactatg gaatcaactg ggtgcgacag gcccctggac
      241 aagggctgga gtggatggga gtgatcatcc cccttgtcgg tatagtgaac tacgtagaga
      301 acctccaggg cagagccacg ataaccgcgg acacgtcaac aaacacagtc tacatggaat
      361 tgaacagcct gagatctgac gacacggcca tctattattg tgcgagagaa tactgtactt
      421 ctgatgcttg cgccggattc tttgactact ggggccaggg agtcccggtc accgtctctt
      481 cagcc
//
LOCUS       KCXD01005054             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19731:7181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005054
VERSION     KCXD01005054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19731:7181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63536.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       425..431
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          111 a          137 c          143 g          102 t
ORIGIN      
        1 acatggggat cacacaacaa ccacttccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagagg cctggggcct cagttaaggt
      181 ctcctgcaag gtttccggat actcgttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtgtatggtg aagaaataca
      301 cgcagataat ttccaggaca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gacctgagga cacggccgtg tatttctgtg cggcgggcct
      421 tgggggatat ttagtgctta ctgaatacct cgaattctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01005055             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17160:8127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005055
VERSION     KCXD01005055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17160:8127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63537.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       442..458
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          116 c          156 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttggtattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcacttata tcgtttgatg
      301 gaactaagca atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt gggggacacg gccgtacatt
      421 actgtgcgag agttagtggg catacagagg gtacagttga atactttgac tactggggcc
      481 agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005056             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12262:2008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005056
VERSION     KCXD01005056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12262:2008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63538.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       424..431
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          136 c          152 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatctct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgaccct ggaaatggtg aaataataca
      301 cgcagatagt ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagaggggg
      421 gttcggtagc agtgtctggt ccaatctcgt ttatggtttg gattcctggg gccaaggggt
      481 cgccgtcacc gtctcctcag cc
//
LOCUS       KCXD01005057             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:28936:9221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005057
VERSION     KCXD01005057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:28936:9221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63539.1"
                     /translation="CARDLNTALSYNSLDVW"
     D_segment       404..410
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..470
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          144 c          124 g          109 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcaataact actggacctg gatccgccaa tccccaggga agggactgga
      241 gtggattgga cgtatctctg gttatggtga cttcaccgcc tacaacccct ccctcgagag
      301 tcgagtctcc atttcaaaag actcgtccaa gagccaattc tccctgaaac tgaactctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat ctcaatacag ccctttcgta
      421 caactcattg gatgtctggg gccggggact tctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005058             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16807:18004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005058
VERSION     KCXD01005058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16807:18004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63540.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       423..432
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          120 a          141 c          127 g          101 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat ccctgcactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agttttaatc ctatttatgg tgaaatttta
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagaagcct gatatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt atccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01005059             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17716:7683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005059
VERSION     KCXD01005059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17716:7683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63541.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          141 c          133 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggttaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga atttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005060             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:23436:15763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005060
VERSION     KCXD01005060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:23436:15763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63542.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          117 c          146 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtaca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 cttgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaact aagaaatact acgtaaactc tataaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atctccaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005061             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:26202:6996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005061
VERSION     KCXD01005061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:26202:6996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..459
     V_segment       108..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63543.1"
                     /translation="CASNSITSGPDYW"
     D_segment       403..409
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           88 a          141 c          130 g          102 t
ORIGIN      
        1 acatggggga atgttctctg agaggcacgg acatcctgtg caagaacatg aggcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccgcctg cagctgcagg
      121 cggcgggccc aggactggtg aagccttcgg agaccctgtc tctcacctgc gctgtctctg
      181 gtggctctat cagcggtaac tactggagct ggatccgccg ggccccaggg aagggactgg
      241 agtggattgg atatatctac ggtagtgatt ttaccaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagca gatacgtcca agaaccagct ctccctgaac ctggcctctg
      361 tgaccgccgc ggacacggcc gtctatttct gtgccagtaa tagtataaca tctggtccag
      421 attactgggg ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005062             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18574:4922
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005062
VERSION     KCXD01005062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18574:4922"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63544.1"
                     /translation="CARGTVTLGTLDSW"
     D_segment       397..405
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          132 c          136 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagt acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc aactgcactg tctctggtgg
      181 ctccatcaga ggttactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggggt gtcggtggta ttactgggat ttcggactac agcccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa ccagttgtcc ctgaatctga ccgttgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagaggtaca gtaaccttgg gaacccttga
      421 ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005063             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:27652:16558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005063
VERSION     KCXD01005063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:27652:16558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63545.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          117 c          152 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc aatacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tacgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005064             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10447:6670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005064
VERSION     KCXD01005064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10447:6670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63546.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          116 c          159 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctccgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatttcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005065             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14320:15050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005065
VERSION     KCXD01005065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14320:15050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63547.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          120 c          154 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagtttct actacatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acgctgatgg
      301 ggatagcaca tactatgcag actccatgaa gggcagattc actatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagca gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctgatcacc gtctcctcag cc
//
LOCUS       KCXD01005066             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:25224:9210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005066
VERSION     KCXD01005066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:25224:9210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63548.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       410..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          133 c          136 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg caggtgcagg
      121 agtcgggccc aggactggtg aagcctccgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctctat cagcagtagt tactgcagct ggatccgcca gaccccaggg aagggactgg
      241 agtggattgg atatatctat gggagtgata gtagtaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtg ctccctgaag ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc gggtatagaa gtggttgcct
      421 acagcattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005067             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16920:4176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005067
VERSION     KCXD01005067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16920:4176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..502
     V_segment       133..426
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63549.1"
                     /translation="CARVTGIDESSVEYFEFW"
     D_segment       433..439
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          117 a          119 c          146 g          122 t
ORIGIN      
        1 acatggggag gagcccagcc ctggaagtcc acagtgttcc attcggtgat cagcacagaa
       61 cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc tattttaaga
      121 ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca gccggggggg
      181 tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagctatgg catgcactgg
      241 gtccgccagt ctccagggca ggggctggaa tgggtggcac ttatatcgta tgatggaact
      301 aagaaatact atgcagactc tgtgaaggac cgattcacca tctccagaga caattccaag
      361 aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt ctattactgt
      421 gcgagagtaa ccggtataga tgaaagttcc gttgaatact tcgagttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005068             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20706:14523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005068
VERSION     KCXD01005068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20706:14523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..451
     V_segment       100..390
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63550.1"
                     /translation="CAGGSRRQPDTW"
     D_segment       402..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           81 a          138 c          138 g           96 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga gcatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaagac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg ggcctggatc cgccagcccc cagggaaggg actggagtgg
      241 attgggtata tcggtggtac tagtgggagc acctactaca acccctccct caggagtcga
      301 gtcatcattt caacagacac gtccaagaat cacttctccc tgaagctgac ctctctgacc
      361 gccgcggaca cggccgtgta ttattgtgcg ggcggaagtc ggcggcagcc ggatacctgg
      421 ggccagggag tcctggtcac cgtctcgtca gcc
//
LOCUS       KCXD01005069             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9672:11615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005069
VERSION     KCXD01005069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9672:11615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63551.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       435..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          113 c          151 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccggtgt gaggtgcaac tggtggagtc tggagggggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcatctg
      301 atggaagtaa gaaatactac gcaaactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catagtatat cttcaaatga acagcctgaa attggaggac acggccgtct
      421 attactgtgc gagagatgat atggggaccg gttttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005070             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20287:12774
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005070
VERSION     KCXD01005070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20287:12774"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..497
     V_segment       134..427
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63552.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       437..443
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..497
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          119 c          153 g          118 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc gatcagcaca
       61 aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa
      121 aggtgtccag tgtgaggtga agctggtgga gtctgggggc ggcttggcaa agcctggggg
      181 gtccctgaga ctctcctgcg cagcctctgg attcaggttc aattattact acatgagctg
      241 ggtccgccag gctccaggga aggggctgga gtggatctca ggtattagta gtggtgggga
      301 aagcacatac tctgcagact ccgtgaaggg cagattcacc atctccagag agaacgccaa
      361 gaacacacta tatcttcaaa tggacagcct gagaactgag gacacggctg tctatttctg
      421 tgtgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc cgggagccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005071             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12778:8927
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005071
VERSION     KCXD01005071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12778:8927"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63553.1"
                     /translation="CARGVDNHHYSETEFDFW"
     D_segment       448..454
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          119 c          152 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggagtctg ggggaggctt ggtacagccg
      181 ggggcgtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtgga tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcggttca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacagc ctgagagctg aggacactgc tgtgtattat
      421 tgtgcaagag gcgtagataa ccaccactac agtgagacgg agtttgactt ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005072             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:16726:5661
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005072
VERSION     KCXD01005072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:16726:5661"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63554.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       401..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           81 a          141 c          137 g          102 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc cccaggaaag gggctggagt
      241 ggattgggtt tttcggtggt tatggtggga gcacctacta caacccctcc ctccagagtc
      301 gagtcaccat ttcagccgac acgtccaaac accagttctc cctgatactg acctctgtga
      361 ccgccgcgga cacggccctc tactattgtg cgagggggaa tatagcagcg actggcattg
      421 actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005073             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19624:12416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005073
VERSION     KCXD01005073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19624:12416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63555.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       424..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          143 c          144 g          103 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatccacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgct cctctatatg gtgaaatgat
      301 gctcgcagac aacttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga cgacacggcc gtgtattact gtgcgcgtgg
      421 gcctattaca atttttggcg tacttattac ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005074             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17635:12231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005074
VERSION     KCXD01005074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17635:12231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63556.1"
                     /translation="CVRDRRVQSLSCFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          111 a          120 c          157 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcaca aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtga agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc aattattact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaata
      301 gtggtgggga aagcacatac tctgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacgcta tatcttgaaa tggacagcct gagaactgag gacacggctg
      421 tctattattg tgtgagagat cgacgtgtac agtcgttatc ctgtttcgat gtctggggcc
      481 cgggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005075             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:20583:9318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005075
VERSION     KCXD01005075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:20583:9318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63557.1"
                     /translation="CARGYCSGSVCSSAFDHW"
     D_segment       420..433
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          131 c          147 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtcaggggct gagatgaaga agcctggggc ctcagtgaag
      181 gtctcttgca aggtttccgg aaacaccttc accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga ggtgttgaac ctggatatgg agaaataata
      301 tattcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagt tgcgcagcct gagatctgag gatacggccg tgtattactg tgcgagggga
      421 tattgtagtg gtagtgtctg ttcgtcggcc tttgaccact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005076             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9014:8391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005076
VERSION     KCXD01005076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9014:8391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63558.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          146 c          134 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaagtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca ggatttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctgtatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta cttggaactg
      361 agcggcctga cttctgagga cacggccgtg tattactgtg cgactggccc taccggcacc
      421 tggaacgcct ggtacctcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005077             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9184:13883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005077
VERSION     KCXD01005077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9184:13883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63559.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       434..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          110 a          119 c          144 g          118 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagttcctct ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg tatgatgaaa
      301 ctaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      361 agaacatggt atatcttcaa atgaacaacc tgaaattgga ggacgcggcc gtttattact
      421 gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc ccggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005078             303 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16495:21535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005078
VERSION     KCXD01005078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 303)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 303)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16495:21535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..301
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..301
     V_segment       8..231
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <223..>270
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63560.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       240..247
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       256..301
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        302..>303
                     /gene="IGHG"
BASE COUNT           63 a           81 c           94 g           65 t
ORIGIN      
        1 acatgggagg cttctggatt cgccttcaga atgtatgccc tcagttgggt gcgacaggcc
       61 cctggacaag ggcttgagtg gatgggaggg atcgtccctc ttgttggaac aacaaactcc
      121 gcacagttcc agggcagagt cacgattacc gcggacacgt ccacaagcac agtctacatg
      181 gagttgagca gcctgagatc tgaggacacg gccatgtatt actgtgcgag aggcctgggt
      241 agcagcgccc actttggttt ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca
      301 gcc
//
LOCUS       KCXD01005079             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13691:2543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005079
VERSION     KCXD01005079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13691:2543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63561.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       443..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          122 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcaccttc actacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctggg gtggctgaca gttatatcgt
      301 ttgatgaaac taaggaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgtgagagat tcttacggcc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005080             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23126:8571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005080
VERSION     KCXD01005080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23126:8571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63562.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          140 c          151 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagccac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgagatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccagga cagagtcacc atgaccgagg acacgtctat agacatagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005081             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13810:11540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005081
VERSION     KCXD01005081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13810:11540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63563.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          122 c          155 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatatt
      241 ggatgaactg ggtccgccag gctccagaga aggggctgga gtgggtctca gctattacta
      301 gtggtgggga tagtacatat tacgcagact ccgtgaaggg tcgattcatc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct tagagcggag gacacggcca
      421 tatattactg tgcgaacgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005082             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:25977:16039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005082
VERSION     KCXD01005082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:25977:16039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..508
     V_segment       127..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63564.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       429..452
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       475..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          116 a          142 c          145 g          107 t
ORIGIN      
        1 acatggggat catcacataa caaccacgtc cctcctctaa agaagcccct gggaacacag
       61 ctcatcacca tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc
      121 cagtcccagg tccagttggt gcagtccggg gctgaggtga agaggcctgg ggcctcagtg
      181 aagctctcct gcaaggctcc tggatacatc ttcagcatat ctgccatcag ttgggtgcga
      241 caggcccctg gacaagggct tgagtggatg ggagggatca tccctcttgt tggtgtaaca
      301 acctacgcac agaagttcca ggacagagtc acgattaccg cggacacgtc cacaagcaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtattt ctgtgcgagt
      421 ggcggcttcg aggatgataa cggtcactat tatacgacac taacatttca cgattggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005083             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7769:13848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005083
VERSION     KCXD01005083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7769:13848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63565.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          140 c          133 g           94 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggagaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggaactga gcagtctgag atctgaggac acggccgtat attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01005084             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9262:10815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005084
VERSION     KCXD01005084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9262:10815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63566.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       419..427
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          113 a          139 c          139 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatggg ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggccg aagtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga cacacctaca gcgaattatc cattcactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggag gtgttggtcc tgtatatggt gaagcactac
      301 acagagacaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg agatctgagg acacggccgt atattactgt gtggcggctg
      421 atagtggtta ccctttttac tacttcgata tctggggccc tggcacccca atcagcatct
      481 cctcagcc
//
LOCUS       KCXD01005085             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20817:3964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005085
VERSION     KCXD01005085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20817:3964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63567.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          141 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcggtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005086             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:7551:3410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005086
VERSION     KCXD01005086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:7551:3410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..484
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63568.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       423..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          121 a          139 c          132 g           94 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacat cttaaccgaa ttatccatgc actgggtgcg acaggcccct
      241 ggagaagggc ttgagtggat gggaagtgtt gatcctcaat atggtgaaat gatagacgca
      301 gagaaattcc agggcagagt caccatgacc gaggacacgt ctacagacac agcctacatg
      361 gaactgagca gtctgagatc tgaggacacg gccgtatatt actgtgcgac atcatccagc
      421 ggcacctggc tatactggta cttcgatatc tggggccctg gcaccccaat caccatctcc
      481 tcagcc
//
LOCUS       KCXD01005087             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20571:13986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005087
VERSION     KCXD01005087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20571:13986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63569.1"
                     /translation="CGNGARRTLGDYW"
     D_segment       393..397
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          138 c          139 g          102 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc acgaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccagatgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatatcggtg gtactagtgg gagcaccttc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgatgc tgacctctgt
      361 gaccgccgcg gacacggccg tctatttttg tggtaacggg gcccgacgta ctttggggga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005088             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7357:11665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005088
VERSION     KCXD01005088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7357:11665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    153..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        153..516
     V_segment       153..444
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63570.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       454..471
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          104 a          157 c          135 g          122 t
ORIGIN      
        1 acatggggga gtctccctca ccacccagct ggggatctca gtgcttcatt ttctgtcctt
       61 catttctcag tgcttcattt ctgtcctcca ccacgatggg gtcaactgcc atcctcgccc
      121 tcctcctggc tgttctccaa ggagtctgtg ccgaggtgca gctggtacag tctggagcag
      181 aggtgaaaag gcccggggaa tctctgagga tctcctgtaa gacttctgga tacagcttta
      241 ccagttactg gatcagttgg gtgcgccaga tgcccgggaa aggcctggag tggatgggaa
      301 tgatctatcc tagtgattct gatcccagat acagcccgtc cttccaaggc caggtcacca
      361 tctcagccga caagtccatc agcaccgcct acctgcagtg gaacagcctg aaggcctcgg
      421 acaccgccac gtattactgt gcgagagctg gacgatacac ctacagttac ccctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005089             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11698:15829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005089
VERSION     KCXD01005089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11698:15829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..356
     V_segment       7..286
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <278..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63571.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       290..297
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       312..356
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           76 a          104 c           97 g           81 t
ORIGIN      
        1 acatggggag tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc
       61 tgtctctggt gactccatca gcagtagcta ctggaactgg atccgtcagc ccccagggaa
      121 gggactggag tggattgggt atatctctgg ttcttatggg agcaccagct acaacccctc
      181 cctcaagagt cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct
      241 gagttctgtg accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc
      301 cattaactac cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005090             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:18318:11397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005090
VERSION     KCXD01005090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:18318:11397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63572.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          111 c          154 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgact caccatctcc agagacaatt
      361 ccaaaaacat ggtatacctt caaatgaaca agttgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005091             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14405:7897
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005091
VERSION     KCXD01005091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14405:7897"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63573.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          116 c          153 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaagac aagagatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01005092             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6955:9460
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005092
VERSION     KCXD01005092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6955:9460"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63574.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       425..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          117 a          145 c          138 g           94 t
ORIGIN      
        1 acatggggga acatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgacgtgaa gaagcctggg gcctctgtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgagtt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt cagtggatgg gaagtgttga tcctgcatat ggtgaaatga
      301 taaacacaga gaagttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtctatttc tgtgcgagtg
      421 gccctagcgg cagctggaac ggctggtact tcgatatctg gggccctggc acccctatca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01005093             340 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17664:10268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005093
VERSION     KCXD01005093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17664:10268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..338
     V_segment       8..279
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <272..>307
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63575.1"
                     /translation="CANALTGGLDYW"
     D_segment       285..293
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..338
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>340
                     /gene="IGHG"
BASE COUNT           76 a           87 c          108 g           69 t
ORIGIN      
        1 acatgggggg ggcggcttgg caaagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtaggt actggatgaa ctgggtccgc caggctccag gaaaggggct
      121 ggagtgggtc tcagctattg caagtggtgg agaaaacaca tactatgcag actccgtgaa
      181 gggccgattc accgtctcca gagacaactc aaagagcaca gtctccctgc aaatgaacag
      241 tcttagaacg gaggacacgg ccgtgtatta ctgtgcgaat gcgttaactg gggggcttga
      301 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005094             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17303:15035
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005094
VERSION     KCXD01005094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17303:15035"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..518
     V_segment       140..439
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63576.1"
                     /translation="CAREAYSWNNLYFYGLDSW"
     D_segment       446..460
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..518
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          112 a          125 c          163 g          120 t
ORIGIN      
        1 acatgggggg ggagaagaga ccccgcctgg gattcccagg agtttccacc tggtgatcag
       61 cactgaacac aaaccaccag ccatggagtt tgggctgagc tgggttttcc ttgttgctat
      121 ttggaaaggt gtccagtgtg aggtgcagct ggtggagtcc gggggaggct tggtccagcc
      181 tggcgggtcc ctgagcctct cctgtgcagc ctctggattc accttcagtg attctggtct
      241 ggactgggtc cgccaggctc caggaaaggg gctggagtgg gtaggtttca ttagaagcaa
      301 aacttatggt gggacagcag aatactccgc gtctgtgaag ggcagattca ccatctccag
      361 agatgattca aagaacacgg cgtatctgca gatgaccagc ctgaaaaccg aggacacggc
      421 cgtatattac tgtgctagag aggcgtatag ttggaacaac ctatatttct acggtttgga
      481 ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005095             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15800:20083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005095
VERSION     KCXD01005095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15800:20083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63577.1"
                     /translation="CARWSAANFDLW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           89 a          134 c          134 g          102 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgag gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggg
      181 ggctccatca acagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtgtatcta tgatagtagt ggaaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa tctgaggtct
      361 atgaccgccg cggacacggc cgtgtttttc tgtgcgagat ggtcggcagc caactttgac
      421 ctctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005096             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11091:8390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005096
VERSION     KCXD01005096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11091:8390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63578.1"
                     /translation="CARDDSGSGFDYW"
     D_segment       434..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          113 c          154 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatct
      121 taagaggtgc ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gtacagcctg
      181 ggggctccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaaataatag atactacgca gactctgtga aggaccgata caccatctcc agagacaatt
      361 cgaggaacat gctgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgatagt gggtccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005097             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5460:7441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005097
VERSION     KCXD01005097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5460:7441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63579.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       423..429
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          140 c          137 g          102 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc
      121 tcttaggttc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacgcagaaa agttccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggagc tgatcagcct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca attggctttt ttggtacttc gatttttggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005098             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18080:9682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005098
VERSION     KCXD01005098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18080:9682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63580.1"
                     /translation="CARGTGAILVYFDYW"
     D_segment       435..441
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          122 c          153 g          115 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt cctgtgtgag ataaaactgg tggagtctgg gggcgacttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cctcaggcac tactatctga
      241 cctgggtccg ccagggtcca gggaaggggc tggagtggat ctcaggtatt aacagtggtg
      301 ggagtagcac atactatgca gactccgtga aggacagatt caccatctcc agagacaacg
      361 ccaagaacac actgtatctt caaatggaca acctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag ggggactggg gcgattcttg tgtactttga ctactggggc cagggagtcc
      481 tggccaccgt ctcctcagcc
//
LOCUS       KCXD01005099             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10272:21354
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005099
VERSION     KCXD01005099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10272:21354"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63581.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          104 a          128 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt gccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc aacctctgga ttcagtttca gttactacta
      241 catgggctgg gtccgccagg ctccagggaa gggtctggaa tggatctcag gtattaacag
      301 tggtggggat accacatact atgcggactc cctgaagggc agattcacca tctccagaga
      361 caacgccaag aacacactgt ctcttcaaat ggacggcctg agagctgagg actcggcagt
      421 ctattactgt gcgcgagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005100             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12409:13666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005100
VERSION     KCXD01005100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12409:13666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63582.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          123 a          140 c          135 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005101             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:28201:13993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005101
VERSION     KCXD01005101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:28201:13993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63583.1"
                     /translation="CATDARGSGLDSW"
     D_segment       441..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          114 c          159 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatgggaat aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caatttcaag aacatgctgt atcttcaaat gaacagcctg aaaatggaag acacggccgt
      421 gtggtactgt gcgacagatg cgaggggttc cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005102             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17483:7397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005102
VERSION     KCXD01005102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17483:7397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63584.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       421..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          141 c          146 g          108 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tctcaggtcc agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag
      181 ctctcctgta aggcttctgg atacagcttc agcatctatg tcatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc
      361 tacatggacc tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt
      421 tactgtactg gcaatggttg taaccttact ttcaaccggc tcgatgtctg gggcccggga
      481 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01005103             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:19504:14852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005103
VERSION     KCXD01005103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:19504:14852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63585.1"
                     /translation="CARDEGEVSGYRFGYW"
     D_segment       450..457
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          113 c          160 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgaaactc tcctgtgcag cctctggatt caccttcagt agctatggca
      241 tccactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtttg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tctagagaca
      361 attccaagaa catgctatac cttcaaatga accacctgag attggaggac acggccatgt
      421 attactgtgc gagggatgag ggggaggtta gtgggtatcg atttggctac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005104             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5542:14973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005104
VERSION     KCXD01005104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5542:14973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63586.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       429..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          147 c          146 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtcag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaattca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtggc agcggctggt ccaacctctt caccggtttg gaatcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005105             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13423:5696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005105
VERSION     KCXD01005105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13423:5696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..520
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63587.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       446..465
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..520
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          112 a          129 c          156 g          125 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcaactg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttacgacatg
      241 acctgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagttacact
      301 ggtaaaacca gatactactc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gtcaagaact ctctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgttcta gagcggctta cgaacatgat gacggttact attacgtcgg caggtttttt
      481 gactgctggg gccagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005106             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21979:11602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005106
VERSION     KCXD01005106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21979:11602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63588.1"
                     /translation="CAIGPSGNWNGWSFDVW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          104 a          140 c          140 g           96 t
ORIGIN      
        1 acatgggggc atccaacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaactgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatggtg
      301 ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta tatggagttg
      361 agcagcctga gatctgagga cacggccgtg tattactgcg cgattggccc tagcggcaac
      421 tggaacggct ggtccttcga tgtctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005107             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17050:6248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005107
VERSION     KCXD01005107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17050:6248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63589.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       417..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          100 a          143 c          127 g          106 t
ORIGIN      
        1 acatggggtc tccctcaccg cacagctggg atctcagttc ttcatttctg tcctccacca
       61 cgatggggtc aactgccatc ctcgccctcc tcctggctgt tctccaagga gtctgtgccg
      121 aggtgaaact ggtgcagtct ggggcagagg tgagaaggcc cggggagtct ctgaagatct
      181 cctgtaagac ttctggatac agctttacca ccaactggat cagttgggtg cgccagacgc
      241 ccgggaaagg cctggaatgg atggggacca tctatcctgc tgattctgag gccaaataca
      301 acccgtcctt ccaaggccac gtcactatct cagccgacaa gtccatcagt accacctacc
      361 tgcagtggag cagcctgaag gcctcggaca ccgccacgta tttctgtgcg aaaacctact
      421 atagtggtag tttggaaatc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005108             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8971:18531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005108
VERSION     KCXD01005108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8971:18531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..428
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63590.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       377..384
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..428
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT           86 a           95 c          135 g          114 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtcctg tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctcgggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg gcatgcactg
      181 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt ctgatggaag
      241 tagcatatac tacgcagcct ctgtgaagga ccgattcacc atctccagag acaattccaa
      301 gaacatgtta tatcttcaaa tgaacaacct gaagtttgag gacacggccg tgtattactg
      361 tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc tggtcaccgt
      421 ctcctcagcc
//
LOCUS       KCXD01005109             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17413:6799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005109
VERSION     KCXD01005109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17413:6799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..492
     V_segment       102..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63591.1"
                     /translation="CARDAGYGDSISLVDINMFPHFDYW"
     D_segment       424..436
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT           98 a          136 c          141 g          119 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctggaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgtgct gtctctggtg
      181 cctccatcag tagttactgg tggacttgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatggt aatagtggta gtgtttactc caacccttcc ctcatcagtc
      301 gagtctccat ttcaaaagac gcgtccaaga atcagttctc cctgaagcta agctctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgagagatgc cgggtatggg gattcgatat
      421 cactagtcga tattaatatg ttcccccact ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005110             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22085:6632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005110
VERSION     KCXD01005110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22085:6632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63592.1"
                     /translation="CAREGISASGVDYW"
     D_segment       401..407
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           83 a          134 c          147 g          100 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg caacttcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtccccaggg aaggggctgg
      241 agtggattgg gtttttcggt ggtcgcaatg ggaacacgta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcacca gacacgtcca aagagcagtt ctccctgagg ctgaggtctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgaggga ggggatatca gcgtcggggg
      421 tcgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005111             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20974:2487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005111
VERSION     KCXD01005111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20974:2487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..468
     V_segment       96..387
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63593.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       417..423
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          107 a          133 c          137 g           93 t
ORIGIN      
        1 acatggggaa gaagcccctg ggaacacagc tcatcaccat ggacttgacc tggagggtcc
       61 tctttgtggt ggcagcagct acaggtgccc agtcccaggt ccaactggtg cagtccgggg
      121 ctgaggtgaa gaagcctggg gcctcagtga agctcccctg caaggcttct ggatacaccc
      181 tcagcatctc taccatcagt tgggtacgac aggcccctgg acaagggctt gagtggatgg
      241 gggagatctt ccctcttgtt ggtaaaacaa aatacgcaca gaagttccac ggcagagtca
      301 cgattaccgc ggacacgtcc gcaagtacag cctacatgga gctgagcggc ctgaaatctg
      361 aggacacggc cgtctattac tgtgcgaaaa gaggtggcca cggtaccacc accacgttgt
      421 acttctttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005112             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22977:11924
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005112
VERSION     KCXD01005112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22977:11924"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..436
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63594.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       443..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          109 a          121 c          159 g          120 t
ORIGIN      
        1 acatgggggc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag tgtgaggtgc agttggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtctctgaga ctctcctgtg taggctctgg attcagcttc agaagttacg
      241 aaatgagttg ggtccgccag gctccgggaa aggggctgga gtgggtctca tatattagtc
      301 acactggtga aaccatatac cacgctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgccaa gaattcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattactg tactagaaac cggaatactg tcatgattgg gtggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005113             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:21421:8783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005113
VERSION     KCXD01005113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:21421:8783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63595.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          134 c          147 g           98 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacgtactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga gcagttctcc ctgaggctga ggtctgggac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005114             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21904:15489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005114
VERSION     KCXD01005114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21904:15489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..447
     V_segment       84..377
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63596.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       386..401
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           87 a          136 c          128 g           98 t
ORIGIN      
        1 acatggggga cctcctgtgc aagaacatga agcacctgtg gttcttcctt ctcctggtgg
       61 ctgctcccag atgggtcctg tcccagctgc atctgcagga gtcgggccca ggactggtga
      121 agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc agcaatagct
      181 actggaactg gatccgccag cccccaggga aggggctgga gtggattggg tctatctatg
      241 gtggtactgg gagcgccggc tacaacccct ccctcaagag tcgagtcacc gtttcaacag
      301 acacgtccaa gaaccagttt tccctgaagc tgacgtctgc gaccgccgcg gacaccgccg
      361 tgtattactg tgcgagatat gaggatgaat acagtgacta ccactttgac tactggggcc
      421 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005115             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19694:8990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005115
VERSION     KCXD01005115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19694:8990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63597.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       460..466
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          107 a          122 c          158 g          126 t
ORIGIN      
        1 acatggggga gctctaggag aggagcccag ccctgggatt cccaggtgtt ttcatttgtg
       61 atcagcactg aacacagaag actcatcatg gagtttggcc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gggtgaggtg cagctggtgg agtctggggg cggcttggca
      181 aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcaccct cagcaactac
      241 tggatgtact gggttcgcca ggcaccaggg aaggggctgg aatgggtctc aagtattaat
      301 agtgttggtg atagtacata ctatgcagac tccgtgaagg gcagattcac catctccaga
      361 gagatcgcca agaacacact gtatcttcaa atggacagcc tgagacctga ggacacggct
      421 gtctattact gtgccagagt gccgggcctg gtggttttca ctggttcgct tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005116             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:9945:10564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005116
VERSION     KCXD01005116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:9945:10564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..498
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63598.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>504
                     /gene="IGHG"
BASE COUNT          120 a          142 c          143 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttcgtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aagtttccgg atacacggtc atcgatttat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgaacatgg tgaagtaata
      301 tacgcagaca acttccaggg cagagtcgcc atgagcgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcgacccac
      421 ggaggatata gaggcatctg gaactcccta tactacggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcccc agcc
//
LOCUS       KCXD01005117             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12095:3672
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005117
VERSION     KCXD01005117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12095:3672"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..511
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63599.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       449..462
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          105 a          123 c          157 g          128 t
ORIGIN      
        1 acatgggggc tctgagacag gagtcttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtggagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca cctttggtga ttatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatccat tagaaacact
      301 ggtaagatcg tatactacgc tgactccgtg aagggccgat tcatcatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agcctgagag tcgaggactc ggccgtctat
      421 tactgtacta gaattggcgt cggatctcta gcaccggctg gtgaatactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005118             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13495:5281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005118
VERSION     KCXD01005118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13495:5281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63600.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       405..425
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           90 a          142 c          130 g          108 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtgtca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcac cagtagcttc tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggtc tatctatggt gctactggga gcaccaccta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgagactg agctctgtga
      361 ccgccgcgga caccgccgtg tattactgtg cgagatatga cgacgatgat tacggttcct
      421 attaccttga ctactggggc cagggagtcc tggtccccgt ctcgtcagcc
//
LOCUS       KCXD01005119             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15345:14908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005119
VERSION     KCXD01005119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15345:14908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63601.1"
                     /translation="CARGRSGGVWPNYFDYW"
     D_segment       429..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          134 c          147 g          101 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga agagggcttg agtggatggg aggtgttgat cctgtgtatg gtgaaattat
      301 tgtcgcagag aatttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagcc tggaatctgc ggacacggcc atctattact gtgcgagagg
      421 gaggagtggt ggtgtctggc cgaactactt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005120             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13273:10081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005120
VERSION     KCXD01005120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13273:10081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63602.1"
                     /translation="CARYPEIQLHLAYFDYW"
     D_segment       413..419
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           99 a          139 c          128 g          109 t
ORIGIN      
        1 acatggggga ggttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctctcc ctcacatgcg ctgtctctgg
      181 tggctctatc agcagtattc actggtggag ctggatccgc cagcccccag ggaaagggct
      241 ggagtggatt gggtatatta gtggtgatag tcgtaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa cagacacgtc caagaaccag ttctccctga agctgagctc
      361 tctgaccgcc gcggactcgg ccgtgtatta ttgtgcgaga tatccagaaa tacaactaca
      421 cttagcctac tttgactact ggggtcaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005121             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:21768:16124
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005121
VERSION     KCXD01005121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:21768:16124"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..506
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63603.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       444..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          119 c          155 g          128 t
ORIGIN      
        1 acatggggga gacaggagtc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgg agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg tagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagaa acactggtaa
      301 aatcgtatac tacgctgact ccgtgaaggg ccgattcatc atctccagag acaacgccaa
      361 gaattcgctg tttctgcaaa tgagcagtct gagagtcgag gactcggccg tctattactg
      421 tactagaatt ggcgtcggat ctctagcacc ggctggtgaa tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005122             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22076:20307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005122
VERSION     KCXD01005122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22076:20307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63604.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       407..415
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           94 a          132 c          136 g          114 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccttcagaga ccctgtccct cacctgcgct gtctctggag
      181 gctctctcag cggtggttat gactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg ctatatctat ggtgctagag ggagcaccac ctacaacccg tccctcagga
      301 atcgagtcac catttcaaaa gacacgtcca agaaccagtt gtccctgaag ttgagttctg
      361 tgaccgccgc ggacacggcc gtatattatt gtgcgagaca gtgctgttat tatgatgact
      421 ttttagacta ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005123             392 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9696:13269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005123
VERSION     KCXD01005123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 392)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 392)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9696:13269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    36..390
                     /note="immunoglobulin heavy chain variable region"
     V_region        36..390
     V_segment       36..315
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>359
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63605.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       323..338
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       341..390
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        391..>392
                     /gene="IGHG"
BASE COUNT           77 a          105 c          125 g           85 t
ORIGIN      
        1 acatgggggt ggcagcagct acaggcgccc actctgaggt ccttctggtg cagtctgggg
       61 ctgaggtgat gcagcctggg gcctcagtga aggtctcctg caaggtttcc ggatacacct
      121 tcaccgaatt gtccatgcac tgggtgcgac aggcccctgg aaaagggctt gagtgggtgg
      181 gaagtgttga tcctgtatat ggtgaaatgg tgttccaggg cggggtcacc atgaccgagg
      241 acacgtctac agacacagcc tacttggagc tgaacagcct gaggtctgaa gacacggccg
      301 tgtattactg tgcgattggc cctagcggca tctggaacgg ctggtccttc gatatctggg
      361 gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01005124             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9707:3713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005124
VERSION     KCXD01005124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9707:3713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63606.1"
                     /translation="CAREEGEASGYRFGYW"
     D_segment       446..454
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          118 a          113 c          157 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgcgatttt
      121 aagaggtgtc caatgtgagg tgcgcctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtacagcctc tggattcacc ttcagtagct atggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat catatgatgg
      301 aagcaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacata ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ttgtgcgaga gaagaggggg aggctagtgg gtaccgattt ggctactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005125             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12552:16793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005125
VERSION     KCXD01005125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12552:16793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..467
     V_segment       98..391
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63607.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       402..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT          108 a          105 c          141 g          115 t
ORIGIN      
        1 acatgggtcg gtgatcagca cagaacacag aggactcacc atgaagtttg ggctgagctg
       61 ggttttcctt gttggtattt taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg
      121 aggaggcttg gttcagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac
      181 cttcagtaac tttggcatgc actgggtccg ccaggctcca gggaaggggc tggagtgggt
      241 ggcacttata tcgtttgatg gaactaagca atactacgca gactctgtga aggaccgatt
      301 caccatttcc agagacaatt ccaagaacat gctatatctt caaatgaaca acctgaaatt
      361 gggggacacg gccgtacatt actgtgcgag agttagtggg catacagagg gtacagttga
      421 atactttgac tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005126             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11738:18400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005126
VERSION     KCXD01005126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11738:18400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..482
     V_segment       122..415
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63608.1"
                     /translation="CSRADIAAAASFDLW"
     D_segment       422..434
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          118 a          142 c          127 g           97 t
ORIGIN      
        1 acatggggga ctcaacaact gcatccaacc tcaagagaag cccctgagag cacagtttcg
       61 caccatggac ttgacctgga agatcctcct cttggtgaca gcagccacag gtgcccactc
      121 ccaggtgcaa ctggttcagt ctggggctga gattaagcag cctggggcct cagtgaagct
      181 ctcctgcaag gcttctggat ataccttcac taactactac atacactggg tgagacaggc
      241 ccctggacaa ggccttgagt ggataggact gatctcccct tataatggtt acaaatcggc
      301 cgcacagagc gtccagggca gagtcaccat aagtgcggac atgtccacga gcacaggcta
      361 catggaacta accagcctga gatctgagga cacagccgtg tattactgtt cgagagcaga
      421 catagcagcg gctgcctcct ttgacctctg gggccaggga gtcctgctca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01005127             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16010:7238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005127
VERSION     KCXD01005127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16010:7238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..448
     V_segment       94..390
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63609.1"
                     /translation="CARWSAANFDYW"
     D_segment       395..401
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           88 a          131 c          137 g           94 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgggc aagaacatga ggcatctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg atgtctcggg gggctccatc
      181 agtagtggtt atggctggag ctggatccgc cagcccccag ggaaggggct ggagtggatt
      241 gggtgtctct acgatagtag tggaaacacc tactacaacc cctccctcaa gagtcgagtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga agctgaggtc tatgaccgcc
      361 gcggacgcgg ccgtgtattt ctgtgcgaga tggtcggcag ccaactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005128             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22675:17365
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005128
VERSION     KCXD01005128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22675:17365"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..451
     V_segment       85..370
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <367..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63610.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       386..393
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT          103 a          108 c          126 g          116 t
ORIGIN      
        1 acatgggctg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
       61 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      121 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      181 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      241 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      301 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      361 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      421 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005129             279 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:11609:13730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005129
VERSION     KCXD01005129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 279)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 279)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:11609:13730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..277
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..277
     V_segment       8..204
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <196..>246
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63611.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       215..229
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       236..277
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        278..>279
                     /gene="IGHG"
BASE COUNT           67 a           71 c           82 g           59 t
ORIGIN      
        1 acatggggga tgtactgggt tcgccaggca ccagggaagg ggctggagtg gatctcagcc
       61 attaatagtg ctgaaagtac cacatactat gcagacgccg tgaagggcag attcaccatc
      121 tccagagaca acgccaagaa cacactgtat cttcaaatgg acagcctgag agctgaggac
      181 acggctgtct attactgtgc gagagtaccg ggcctagtgg tgtttactgg ttcccttgac
      241 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005130             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16699:15265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005130
VERSION     KCXD01005130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16699:15265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63612.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       433..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          146 c          141 g           97 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tccccaacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggac ttgttgatcc tgtaaatggt gaactaatac
      301 acgcagacaa gttccagggc agagtcacca tgaccgaaga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg acatctgagg acacggccat ctactactgt gcgacaggga
      421 ggatcggtac cagtggctgg tccaacctct tcaatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01005131             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12302:14562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005131
VERSION     KCXD01005131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12302:14562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..494
     V_segment       131..424
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63613.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       434..440
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          111 a          117 c          149 g          119 t
ORIGIN      
        1 acatgggagg agcccagccc cagaattccc aggtgtttct gttcggcgat cagcacaaaa
       61 cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc ttttgaaagg
      121 tgtccagtgt gaggtgaagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc
      181 cctgagactc tcctgcgcag cctctggatt cagcttcaat tattactata tgagttgggt
      241 ccgccaggct ccagggaagg ggctggagtg gatctcaggt attaatagtg gtggggaaag
      301 cacatactct gcagactccg tgaagggcag attcaccatc tccagagaga acgccaagaa
      361 aacagtatat cttcaaatgg acagcctgag aactgaggac acggctgtct attactgtgt
      421 gagagatcga cgtgtacagt ccttatcctg gttcgatgtc tggggcccgg gagccctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005132             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11818:6468
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005132
VERSION     KCXD01005132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11818:6468"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..498
     V_segment       141..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63614.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       444..449
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          103 a          115 c          162 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagt tggtggagtc tgggggcggc ttggcacagc
      181 ctggggggtc cctgagactc tcctgttcag cctctgggtt caccttcagt aggcactgga
      241 tgaactgggt ccgccaggct ccaggaaagg ggctagagtg ggtctccggt attaatagtg
      301 gtggggatac tacatactac gtagactccg tgaagggccg attcaccatg tccagagaca
      361 attcaaagaa cactctctcc ctgcaaatga acagcctgag agcggaggac acggccgtgt
      421 attattgtgt gcaaggggaa atttttggag tgggtttgga tttctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005133             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21913:9370
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005133
VERSION     KCXD01005133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21913:9370"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63615.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          125 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagtttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggat tggatctcag gtattaacgg
      301 tggtggggat accacctact atgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005134             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17434:6856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005134
VERSION     KCXD01005134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17434:6856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63616.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       232..238
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       244..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           72 a           72 c           79 g           66 t
ORIGIN      
        1 acatggggga ttcaccttca gtacctctgg catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tggctgacag ttatatcgta tgatgagact aagaaatact acgcagactc
      121 tgtgaagggc cgattcacca tctccagaga caattccaaa aacatgctat atcttcaaat
      181 gaacaacctg aaattggagg acgcggccgt gtattactgt gcgagagatt cttacggtcg
      241 aggctttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005135             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22228:5286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005135
VERSION     KCXD01005135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22228:5286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63617.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       447..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          117 c          158 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttggac tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcggcctctg gattcacctt cagtacctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ggttatatcg
      301 aatgatgaga gtaagaaata ttacgcagac tctgtgaagg gccgattcag catctccaga
      361 gacaattcga agaacatgct atatcttcac atgaacaccc tgaaattgga cgacacggcc
      421 gtgtattact gtgcgacaga tgcgtttggt agcgggattg accactgggg ccagggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01005136             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8624:11796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005136
VERSION     KCXD01005136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8624:11796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..492
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63618.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          138 c          150 g           97 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagaccggg gctgcggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacc ttcagcatct atgtcatcaa ttgggtgcgc caggcccctg
      241 gacaagggct agagtggatg ggagggatca tccctcttgt tggtacaaca aactacgcac
      301 agaggttcca gggcagagtc acgattattg cggacacgtc cacaagcaca gcctacatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga ggccccccta
      421 ctgaaggggg tgattattct gggggggctt tgagccgatg gggccaggga gtccaggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005137             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20755:4200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005137
VERSION     KCXD01005137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20755:4200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63619.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          138 c          128 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattggct atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaactga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005138             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20666:8694
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005138
VERSION     KCXD01005138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20666:8694"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..522
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63620.1"
                     /translation="CAKVDHEDDYGFYYTWSYFDSW"
     D_segment       442..469
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..522
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT          112 a          129 c          159 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga cttacctgtg cagcctctgg attcaccttc agtaggtatg
      241 ccatgcactg ggtccgccag gctccagaca aggggctgga gtgggtctca gttattagta
      301 gtggtggtag cacatactac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagac cacgctctcc ctgcaaatga acagcctgag acctggggac acggccgtgt
      421 attactgtgc gaaagttgat cacgaggatg attacggttt ctattacact tggagttact
      481 ttgactcctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005139             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12192:9738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005139
VERSION     KCXD01005139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12192:9738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63621.1"
                     /translation="CARNRFMGIRPLAYW"
     D_segment       410..416
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           99 a          136 c          127 g          104 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtcc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tgactccatc agtggttact actggaactg gatccgccaa ccaccaggga agggactgga
      241 gtggattggg tatatcgctg gtagtagtgg gagcacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgaactctgt
      361 gaccgccgcg gacacggcca tctattactg tgcgagaaat agatttatgg gtataaggcc
      421 tcttgcctac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005140             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:23026:12509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005140
VERSION     KCXD01005140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:23026:12509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63622.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       439..450
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          119 c          152 g          117 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccattg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcac taactatggc
      241 atgcactggg tccgccaggc tccagggaag ggtctggagt gggtggcagt tatgtcgcat
      301 gatgggacta agaaattcta cgcagactct gtgaaggacc gattcaccat ctccagggac
      361 aattccaaga acatggtata tcttcaaatg aacaacctga gattggagga cgcggccgtc
      421 tattactgtg cgagaggaga ctacggtaac agccttgact actggggcca gggagtcctg
      481 ctcaccgtct cctcagcc
//
LOCUS       KCXD01005141             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21285:18206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005141
VERSION     KCXD01005141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21285:18206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63623.1"
                     /translation="CARWGTPFDYW"
     D_segment       400..404
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           89 a          134 c          133 g          100 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcttgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 agctccatca acagtggtta tgcctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtgggttg ggcatatcta tgatagtagt gggaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagat gggggacccc ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005142             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12389:21084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005142
VERSION     KCXD01005142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12389:21084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63624.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       433..439
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          142 c          143 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaaat gaagaagcct ggggcctcag ttagggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggatgtgt cgatcctgca caaggtgaaa taatacacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tccacagaca cagccttcat
      361 ggagttgagc agcctgagat ctgaggacac ggccgtgtat ttctgtgcga aaggggggtt
      421 cggaaccagc gtctggtcca acctcttcta cggcttggat tcttggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005143             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11370:20502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005143
VERSION     KCXD01005143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11370:20502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..501
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63625.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       421..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>507
                     /gene="IGHG"
BASE COUNT          113 a          138 c          146 g          110 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaaga cttctggata caccttcagc atctctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgggtg gatgggaggg atcatccctc ttgttggtgt gacaaactac
      301 gaacagaagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      361 atggaactga gcagcctgag atctgaggac acggccgtct actattgtgc gacaggggta
      421 tattaccagg atgaatacgg ttatttttat gtcggcggtg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01005144             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17680:7994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005144
VERSION     KCXD01005144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17680:7994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..479
     V_segment       102..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63626.1"
                     /translation="CTRLGGGYSGSWLNWFFDVW"
     D_segment       410..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           92 a          142 c          139 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc gaggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggggg
      181 ctccatcagc agcgcttcct actggagctg gatccgccaa tccccagggg aggggctgga
      241 gtggattggg tatatcgctg gcggtggtgt tttcacctac tacaacccct ccctcaagaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccaactc tccctgaagc tacattctgt
      361 gaccgccgcg gacacggccg tgtattattg tacgagattg ggggggggtt atagcggcag
      421 ctggctaaac tggttcttcg atgtctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01005145             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14510:13490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005145
VERSION     KCXD01005145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14510:13490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63627.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       425..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>494
                     /gene="IGHG"
BASE COUNT          113 a          145 c          140 g           96 t
ORIGIN      
        1 acatggggga acatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatccacct tcaccgagtt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt cagtggatgg gaagtgttga tcctgcatat ggtgaaatga
      301 taaacgcaga gaagttccag ggcagagtca ccctgaccga ggacacgtct acatacacag
      361 cctacatgga gctgagcagc ctgtcatctg aggacacggc cgtgtatttc tgtgcgagtg
      421 gccctagcgg cagctggaac ggctggtact tcgatttctg gggccctggc accccaatca
      481 ccgtctcctc aacc
//
LOCUS       KCXD01005146             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20382:4788
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005146
VERSION     KCXD01005146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20382:4788"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63628.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           88 a          143 c          130 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctgctgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtggcttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctctggtg ctactgggag taccagctac accccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctgc actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gcggatgatt acggttatta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005147             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17026:7918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005147
VERSION     KCXD01005147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17026:7918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..478
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63629.1"
                     /translation="CVRYGADYEDDYDYYSFDYW"
     D_segment       407..432
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           97 a          133 c          135 g          115 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacttgcgc tgtctctggt
      181 gactccatca ccagtagctt ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatctatgg cagtactggg agcaccggct acaatacctc cctcaagagt
      301 cgagtctcca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gaattctgtg
      361 accgccgcag acaccgccgt gtatttctgt gtgagatatg gggcggatta cgaggatgat
      421 tacgattact atagttttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005148             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18240:14002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005148
VERSION     KCXD01005148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18240:14002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63630.1"
                     /translation="CATGPSGTWNAWYLDMW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          111 a          141 c          135 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga tacagcttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tttatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgac atctgaggac acggccgttt attactgtgc gactggccct agcggcacct
      421 ggaacgcctg gtacctcgat atgtggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01005149             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16814:7980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005149
VERSION     KCXD01005149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16814:7980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63631.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          149 c          141 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aggggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggact tgaccagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005150             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:17216:17362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005150
VERSION     KCXD01005150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:17216:17362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..507
     V_segment       137..430
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63632.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       453..460
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>511
                     /gene="IGHG"
BASE COUNT          103 a          129 c          158 g          121 t
ORIGIN      
        1 acatggggtc tgagacagga gccttagccc tggattccaa gaacttccac tttgggatca
       61 gctctgaaca cagaggacca tggagttggg gctgagctgg gttttccttg ttgctatttt
      121 aaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg tccagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc tttggtgatt atggcatgca
      241 ctgggtccgc caggctccgg gaaagggact ggagtgggtc tcatccatta ggaacactgg
      301 taaaatcgta tactacgctg actccgtgaa gggccgattc accatttcca gagacaacgc
      361 caagaactcg ctgtctctgc gaatgagcag cctgagagcc gaggacacgg ccgtgtacta
      421 ctgtactaga attggcgtcg gatctctggc aacggctggt gactactttg accactgggg
      481 ccagggagtc ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01005151             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12239:8576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005151
VERSION     KCXD01005151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12239:8576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..500
     V_segment       120..411
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63633.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       420..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>506
                     /gene="IGHG"
BASE COUNT          113 a          138 c          145 g          110 t
ORIGIN      
        1 acatgggaca taacaaccac gtccctcctc taaagaagcc cctgggaaca cagctcatca
       61 ccatggactt gacctggagg ctcctctttg tggtggcagc agctacaggt gcccagtccc
      121 aggtccacct ggtgcagtcc ggggctgagg tgaagaggcc tggggcctca gtgaagctct
      181 cctgcaaggc ttctggatac accttcagca tctctgccat cagttgggtg cgacaggccc
      241 ctggacaagg acttgggtgg atgggaggga tcatccctct tgttggtatg acaaactacg
      301 aacagaagtt ccagggcaga gtcacgatta ccgcggacac gtccacgaat acagtcttca
      361 tggaactgag cagcctgaga tctgaggaca cggccgtcta ctattgtgcg acaggggtat
      421 attaccagga tgaatacggt tatttttatg tcggcggtga ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc ccagcc
//
LOCUS       KCXD01005152             288 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8123:5790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005152
VERSION     KCXD01005152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8123:5790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..286
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..286
     V_segment       7..224
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>255
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63634.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       231..242
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       243..286
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        287..>288
                     /gene="IGHG"
BASE COUNT           61 a           85 c           82 g           60 t
ORIGIN      
        1 acatggggtg gctctatcaa catttactac tggaattgga tccgccaggc cccagggaag
       61 ggactggact ggattggaca tatctatggt agcggtggta gcaccaacta caacccctcc
      121 ctcaagagtc gagtcaccct gtcagtggac acgtccaaga accacttctc cctgaacctg
      181 aggtctgtga ccgccgcgga cacggccgta tattactgtg cgagcggtcg gcggcagctg
      241 gactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005153             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:6943:10455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005153
VERSION     KCXD01005153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:6943:10455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63635.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       412..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          114 a          135 c          132 g          105 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacttg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggcgca gtctggggct gacgtgaaga agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccttc accgaattat ccctgcactg ggtgcgacag
      241 ggccctggaa aaggacttga gtggatggga ggttttgctc ctatatatgg tgaattaatc
      301 catgaaaggt tccagggaag agtcagtttg accgaggaca cgtccacaga cacagcctat
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc ggcagctgat
      421 agtggttacc cattttacta cttcgatatc tggggccctg gcaccccaat caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01005154             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16926:5113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005154
VERSION     KCXD01005154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16926:5113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..418
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63636.1"
                     /translation="CAKGGWWGDYPPSDWFDVW"
     D_segment       428..439
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..497
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT           98 a          148 c          144 g          109 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggagactca gtgcttcctt ttctgtcctc
       61 caccacgatg gggtcaactg ccatcctcac cctcctactg gctgttctcc aaggagtctg
      121 tgccgaggtg ctgctggtgc agtctggagc agaggtgaaa aggcccgggg agtctctgaa
      181 gatctcctgt aagacttctg gagacacctt aacctactat tggatcagct gggtgcgcca
      241 gatgcccggg aaaggcctgg agtggatggg ggcgattgat cctggtgatt ctaataccaa
      301 atacagcccg tccttccaag gccaggtcac catctcagcc gacaagtcca tcagcaccgc
      361 ctacctgcag tggaccagcc tgaaggcctc ggacaccgcc acctattatt gtgcgaaagg
      421 ggggtggtgg ggtgattatc caccctcaga ctggttcgat gtctggggcc cgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005155             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18753:13497
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005155
VERSION     KCXD01005155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18753:13497"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63637.1"
                     /translation="CATVGPYHYFDYW"
     D_segment       432..437
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          146 c          137 g           94 t
ORIGIN      
        1 acatgggcaa cgcagagtac atgggggaca caaccaccac atccctcccc tacagaagcc
       61 ccagagcaca gcacctcacc atggactgga cctggaggct cctcctcttg gtggcagcag
      121 ctacagacgc ccactccgag gtccagctgg tacagtctgg ggctgaggtg aagaaacctg
      181 gggcctccgt gaaaatctcc tgcaaggctt ctggatacac cttaaccgac cactaccttc
      241 actgggtgcg acaggctcct ggaaaaggac ttgagtggat gggaggtctt catcctgagt
      301 atggtaaagc ggactacgct cagaggttcc agggcagagt caccatcacc gcggacatgt
      361 ctacagagac agcctacatg gagctgagca ccttaagatc tgaggacacg gccgtgtatt
      421 actgtgcgac agtgggtccc taccattact ttgactactg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01005156             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:27736:10211
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005156
VERSION     KCXD01005156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:27736:10211"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63638.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          138 c          135 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacttgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa gtccaaggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcgtc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcgtcagcc
//
LOCUS       KCXD01005157             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16428:9481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005157
VERSION     KCXD01005157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16428:9481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63639.1"
                     /translation="CAKSRSSSLHWDFDFW"
     D_segment       442..448
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          132 c          151 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg aatctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtcggggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggta aggggctgga gtgggtctca gctatgagtg
      301 ttgctggaag cacatactac gcaggctccg tgaagggccg attcaccgtc tccagagaca
      361 actcaaagaa catgttctcc ctgcaaatgg acaacctgac acctgaggac acggccgtgt
      421 attactgtgc gaaaagtcgg agtagtagcc ttcactggga cttcgatttc tggggccctg
      481 gcaccccaat cacaatctcc tcagcc
//
LOCUS       KCXD01005158             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12041:8362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005158
VERSION     KCXD01005158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12041:8362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63640.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          114 c          149 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gaacccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttattgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtagctatgg
      241 cttacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgtc
      301 tgatgaaagt aggaaatact acgcagactc tctgaaggac cgattcacca tttccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgt gcgagggatg ataatggggt gcttatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005159             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20664:7748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005159
VERSION     KCXD01005159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20664:7748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63641.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..410
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          137 c          139 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcggc tgcaggagtc
      121 gggcccagga cttgtgaagc tttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggggctggat ccgccggccc ccaggggagg gtctggagtg
      241 gattgggtat atcagtggga gtggtgggag ttccgactac aagtcctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005160             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16358:7609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005160
VERSION     KCXD01005160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16358:7609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63642.1"
                     /translation="CATSSSGTWLYWYFDLW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          144 c          132 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgccgag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagtc tgagatccga ggacacggcc gtatattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatctctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005161             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:18622:12489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005161
VERSION     KCXD01005161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:18622:12489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63643.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          137 c          127 g          110 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgag gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgtcagc ccccagggaa gggactggag
      241 tggattggtt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gacttctgtg
      361 accgccgcgg acaccgccat gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005162             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10562:6552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005162
VERSION     KCXD01005162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10562:6552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63644.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          117 c          149 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcgccctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccagactcca gggaaggggc tggagtgggt ggcagttttg tcgtctgatg
      301 gaggttacaa ataccacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005163             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:27854:10647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005163
VERSION     KCXD01005163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:27854:10647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63645.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          119 a          144 c          136 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acgaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatccac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccctctcctc agcc
//
LOCUS       KCXD01005164             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7416:16103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005164
VERSION     KCXD01005164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7416:16103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..493
     V_segment       136..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63646.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       435..442
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          118 a          116 c          145 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag accacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt ccaactggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagcaacta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtacgatgaa
      301 agtaagaaat actacgcaga ctctctgaag gaccgattca ccatctccag agacaattcc
      361 aagaacatgc tttatcttca aatgaacaac ctgaaaatgg aggacacggc cgtttattac
      421 tgtgcgagga ggccctggaa tgcagatgct tttgatttct ggggccaagg actcagggtc
      481 accgtctctt cagcc
//
LOCUS       KCXD01005165             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24227:11075
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005165
VERSION     KCXD01005165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24227:11075"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..472
     V_segment       106..402
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63647.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       407..420
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          133 c          142 g          106 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcatg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacttg cgttgtctct
      181 ggccactcca tcagcagtgg ctaccactgg ggctggatcc gtcagccccc agggaaggga
      241 ctggactata ttggctatat cagtggtagt agtgggagca cctactacaa gccctccctc
      301 atgagtcgag tcatcatttc aagagacacg tcccggaatg agttctccct gaggctgagg
      361 tctgtgactg tcgcggacac ggccgtgtat tattgtgcga gacgagatag ctggaacaac
      421 ggggggagcc ttgactactg gggccaggga ttcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005166             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13478:12433
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005166
VERSION     KCXD01005166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13478:12433"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63648.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       441..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          114 c          153 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaaa tcgtttgatg
      301 gaaccaagat atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcctac gggagcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005167             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7901:16301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005167
VERSION     KCXD01005167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7901:16301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63649.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       428..435
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          143 c          152 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcacctt ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 gctctgaggt ccaactggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacacct tcaccgactt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga ccctgcaaat ggtgaaataa
      301 tacacgcaga tagtttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcggc ctgcgatctg aggacacggc cgtttattac tgtgcgagag
      421 ggggcttcgg tagcagtgtc tggtccaatc tcgtctatgg tttggattcc tggggccaag
      481 gggtcgccgt caccgtctcc tcagcc
//
LOCUS       KCXD01005168             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20810:12476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005168
VERSION     KCXD01005168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20810:12476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63650.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       443..448
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          116 c          154 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaaga ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gtagcctctg gattcacctt cagtagctat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tacgatgaag acaagagata ctacgcagac tctctgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct ttatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtttattact gtgcgaggag gccctggagt gcagatgctt ttgatttctg gggccaagga
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01005169             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:12266:15938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005169
VERSION     KCXD01005169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:12266:15938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63651.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          141 c          152 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgggttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005170             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5696:7494
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005170
VERSION     KCXD01005170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5696:7494"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63652.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          111 a          141 c          133 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ataccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgcgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01005171             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:25108:15423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005171
VERSION     KCXD01005171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:25108:15423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..467
     V_segment       98..394
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63653.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       410..417
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          140 c          130 g          102 t
ORIGIN      
        1 acatggggct ctgagagtca tggacctcct gtgcaggaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgaagctgc aggagtcggg
      121 tccaggactg gtgaagcctt cagagaccct gtccctcacc tgcgctgtct ctggaggctc
      181 tatcagcggt gtttatgact ggacctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat gtccatggtg atactgggaa caccgactac aacccgtccc tcaagaatcg
      301 agtcaccatt tcaaaagaca cgtccaagaa ccagttctcc ctgacgctga ggtctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagacgccca gaaaacagtt actacttcta
      421 ctactttgac tactggggcc acggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005172             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20252:17912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005172
VERSION     KCXD01005172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20252:17912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63654.1"
                     /translation="CARVGEGSGGAEDLDFW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          111 a          114 c          164 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcattg ggtccgccag gctccaggga aggggctgga gtgggtggca cttatatcgt
      301 atgatggatc taagaaatac tacgcagact ctgtgaagga ccggttcacc atctccagag
      361 acaattccga gaacaaggta tatcttcaga tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagtt ggagagggta gtggtggtgc ggaggacctt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005173             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21205:7977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005173
VERSION     KCXD01005173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21205:7977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63655.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       438..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          109 a          114 c          150 g          118 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 agcacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtaaaatcg tttgatggaa
      301 ctaagatata ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      361 agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtttattact
      421 gtgtgagaga tgcctacggg agcggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005174             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20777:10568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005174
VERSION     KCXD01005174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20777:10568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63656.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       411..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          150 c          131 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcccggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaattgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttca gtgggtggga agtgttgatc ccgcatatgg tgaaatgacg
      301 ttccagggca gagtcatcat gaccgaggac acgtctacag acacagccta catggagctg
      361 accagcctga catctgacga cacggccgtc tattactgtg cggttggccc tagcggcact
      421 tggaaccact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005175             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21965:10529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005175
VERSION     KCXD01005175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21965:10529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..472
     V_segment       121..395
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63657.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       404..418
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          115 a          134 c          134 g           91 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc agagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tgatgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg ttaccggata caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag gacttgagtg gatgggaagt gttgatcctg tatatggtga aatgaaagag
      301 ggcagagtca ccatgaccga ggacacgtct acagacacag cctacatgga actgagtagc
      361 ctgagatctg aggatacggc cgtgtattat tgtgcagtcg gcaatagcgg cagctggatc
      421 tcctggtcct tcgatgtctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01005176             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15096:10627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005176
VERSION     KCXD01005176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15096:10627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..478
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63658.1"
                     /translation="CARYGADYEDDYDYYSFDYW"
     D_segment       407..432
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           97 a          133 c          138 g          112 t
ORIGIN      
        1 acatggggag gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcagttgcgc tgtctctggt
      181 gactccatca ccagtagctt ctggagttgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatctatgg gagtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtctcca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gaattctgtg
      361 accgccgcag acaccgccgt gtattactgt gcgagatatg gggcggatta cgaggatgat
      421 tacgattact atagttttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005177             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20411:6926
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005177
VERSION     KCXD01005177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20411:6926"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63659.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       409..430
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           96 a          142 c          134 g          117 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgca gccttcggag accctgtccc tcacatgcgc tgtctctggt
      181 ggctctatca gcagtactaa atggtggagc tggatccgcc agcccccagg gaaagggctg
      241 gagtggattg ggtatatcag tggtagtagt ggtaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac ggacacgtcc aacaaccagt tttccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtttattat tgtgcgagat cccaatccta ttgtagtggg
      421 ctttactgct tcggctacta ctactttgac tactggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01005178             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:3657:17427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005178
VERSION     KCXD01005178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:3657:17427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..476
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63660.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          147 c          132 g           94 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacat
      301 tccagggcag agtcttcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac gcggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gtccttcgat atctggggcc ctggcaccca atcaccatct cctcagcc
//
LOCUS       KCXD01005179             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14981:10787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005179
VERSION     KCXD01005179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14981:10787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63661.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          117 a          114 c          151 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcacgttca gtaactatgg
      241 aatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01005180             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:25095:5027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005180
VERSION     KCXD01005180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:25095:5027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..435
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63662.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       452..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          107 a          124 c          157 g          128 t
ORIGIN      
        1 acatgggggc agctctgaga caggagtctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtggag ctggtggagt ctgggggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtgta gcctctggat tcacctttgg tgattatggc
      241 atgcactggg tccgccaggc tccgggaaag ggactggagt gggtctcatc cattagaaac
      301 actggtaaaa tcgtatacta cgctgactcc gtgaagggcc gattcatcat ctccagagac
      361 aacgccaaga attcgctgtc tctgcaaatg agcagcctga gagtcgagga ctcggccgtc
      421 tattactgta ctagaattgg cgtcggatct ctagcaccgg ctggtgaata ctttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005181             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:25715:16170
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005181
VERSION     KCXD01005181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:25715:16170"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63663.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          113 a          144 c          140 g           95 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga accctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gtcatctgag gacacggccg tgtatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatttctggg gccctggcac tccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01005182             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13296:20210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005182
VERSION     KCXD01005182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13296:20210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..426
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63664.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       370..378
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>430
                     /gene="IGHG"
BASE COUNT           95 a           93 c          137 g          105 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg gcatgcactg
      181 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga atgatggaag
      241 taagaagtac tacggagact ctgtgaagga ccgattcacc atctccagag acaattccaa
      301 gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag tgtattactg
      361 tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc tggtcaccgt
      421 ctcctccgcc
//
LOCUS       KCXD01005183             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16033:3373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005183
VERSION     KCXD01005183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16033:3373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63665.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          121 a          143 c          143 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctgggac ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtggcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tatatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005184             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:19153:9065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005184
VERSION     KCXD01005184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:19153:9065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63666.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          139 c          135 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct aaatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtgcttcga tatctggggc cctggcaccc cgatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005185             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21665:2513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005185
VERSION     KCXD01005185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21665:2513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63667.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          109 c          157 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggatttac tttcagtagt agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgaa tcgcatgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca gcctgaaatt ggtggatacg gccatgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005186             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:8980:4809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005186
VERSION     KCXD01005186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:8980:4809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..476
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63668.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       420..435
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>479
                     /gene="IGHG"
BASE COUNT          102 a          147 c          125 g          105 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggaacag aggtgaaaag gcccggggag tctctgagga
      181 tctcctgtca gacctctgga tacaactttc ccagcagctg gatcacctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatgggga ccatctatcc tgctgattct aatgccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctcagtcga caagtccatc agcaccacct
      361 acttgcagtg gagcaacctg aaggcctcgg acaccgccac gtattactgt gccaaaacct
      421 actatagtgg tagtttggaa tactggggcc agggagtcct ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01005187             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10232:12161
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005187
VERSION     KCXD01005187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10232:12161"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..511
     V_segment       136..427
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63669.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       463..469
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          113 a          121 c          158 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggta tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcgcctggtg cagtctgggg gcggcttgac aaagcctggg
      181 gggtccctga gactctcctg tgcagcctcc ggattcacct tcagtgacta ctatatggac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtct cacgaatcaa tcatgatggc
      301 actagtacat ggtacgcaga ctccgtgaag ggcagattta ccatttccag agagaatgcc
      361 aagaacacac tgtttctgca aatggacagc ctgagaagtg aggacacagc cgtatattac
      421 tgtgcgagag agcggtttgg gggaattggg gtaattatct tcaactggat cgatgtctgg
      481 ggtccgggag tcctggtcac cgtcccctca gcc
//
LOCUS       KCXD01005188             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13547:13802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005188
VERSION     KCXD01005188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13547:13802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..512
     V_segment       142..435
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63670.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       458..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>516
                     /gene="IGHG"
BASE COUNT          105 a          130 c          159 g          122 t
ORIGIN      
        1 acatgggggc agctctgaga caggagcctt agccctggat tccaagaact tccactttgg
       61 gatcagctct gaacacagag gaccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggtccag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttgg tgattatggc
      241 atgcactggg tccgccaggc tccgggaaag ggactggagt ggatctcatc cattaggaac
      301 actggtaaaa tcgtatacta cgctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga actcgctgtc tctgcgaatg agcagcctga gagccgagga cacggccgtg
      421 tattactgta ctagaattgg cgtcggatct ctggcaacgg ctggtgacta ttttgaccac
      481 tggggccagg gagtcctggt caccgtctcc tccgcc
//
LOCUS       KCXD01005189             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7483:15630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005189
VERSION     KCXD01005189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7483:15630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..438
     V_segment       69..362
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63671.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       363..374
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           96 a          122 c          130 g           92 t
ORIGIN      
        1 acatggggac catggactgg acctggaggc tcctctttgt ggtggcagca gctgcaggtc
       61 tccagtccca ggtccacctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag
      121 tgacggtttc ctgcggggcc tctggattca ccttcgacac ccatggaatc aactgggtgc
      181 gacaggcccc tggacaaggg cttgagtgga tgggagtgat catccccctt attggtatca
      241 caaactacgc aaagaactct cagggcagag tcacaataac cgcgaacacg tccacaaaca
      301 cagcctacat ggagctgagc agcctgagat ctgaggacac ggccatctat tattgtgcga
      361 gagaatactg tacttctagt agttgcgccg ggttccttga ctactggggc cagggagtcc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005190             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23753:13608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005190
VERSION     KCXD01005190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23753:13608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..327
     V_segment       8..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63672.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       257..263
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..327
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>331
                     /gene="IGHG"
BASE COUNT           80 a           88 c           90 g           73 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caaggtttcc gactacacct tcgccgaatt
       61 acccatacac tgggtgcgac aggcccctgg aaaagggctt gagtggatgg gaggttttgc
      121 tagtatatat ggtgaaataa tacatacaga gagattccag ggcagagtca ccatgacagc
      181 ggacacgtct acagacacag cctacatgga gctgagcagc ctgacatctg aggacacggc
      241 cgtgtattac tgtgcggcag ctgatagtgg ttacccattt tactacttcg atatctgggg
      301 ccctggcacc ccgatcacca tctcctccgc c
//
LOCUS       KCXD01005191             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17822:6079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005191
VERSION     KCXD01005191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17822:6079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63673.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          143 c          129 g           92 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccaa gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtagacta
      301 cacacagaag ttccgagaca gagtcaccat caccgcggac atgtcgacag agacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005192             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15754:13274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005192
VERSION     KCXD01005192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15754:13274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63674.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          110 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcattc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaggaa atactacgca gactctgtga aggaccaatt caccatatcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccacgtatt
      421 actgtgtgag agatgtcagg ggaacgggat ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005193             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18211:4382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005193
VERSION     KCXD01005193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18211:4382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63675.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       430..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          116 c          146 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc ggggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt acctctggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg gctgacagtt atatcgtatg atgagactaa
      301 gaaatattac gcagactctg tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 catgctatat cttcaaatga acaacctgaa attggaggac gcggccgtgt attactgtgc
      421 gagagattct tacggtcgag gctttgactc ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005194             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9107:18493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005194
VERSION     KCXD01005194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9107:18493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63676.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       435..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          116 c          150 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgac ctgggttttc cttgttgcta
      121 ttttaggagg tgtccggtgt gaggtgcgac tggtggagtc tgggggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcagtt atttcgtctg
      301 atggaagtaa gaaatactac gcaaactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catactatat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagatgat cttgggaccg gttttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005195             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:17306:6250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005195
VERSION     KCXD01005195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:17306:6250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63677.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       446..452
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          153 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgctggaag taagaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag
      361 acgactccag gaacatgcta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct gggggcttga ctactggggc cagggagtcc
      481 tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01005196             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:21149:16551
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005196
VERSION     KCXD01005196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:21149:16551"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63678.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       444..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          120 c          145 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga aatttgggct gagctgggtt ttccttgcag
      121 ctattttaag aggtgtccaa tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggaa aggggctgga atgggtggca gttatatcgt
      301 ctgatggaag tagaaaatac tacgcagact ctttgaaagc ccgattcacc atatccagag
      361 acaactccaa gaacatactc tatcttcaac tgaacaacct gaaattggag gacacggcca
      421 tatattactg tgcgagagat gtgtatgggt cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01005197             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18465:20121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005197
VERSION     KCXD01005197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18465:20121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63679.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       446..452
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          119 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tacgccgact ctttgaaaga ccgattcacc atatccagag
      361 acgactccag gaacatgcta tatcttcaac tgaacaacct gaaattagac gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct gggggcttga ctactggggc cagggagtcc
      481 tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01005198             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23021:10314
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005198
VERSION     KCXD01005198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23021:10314"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63680.1"
                     /translation="CATADYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          117 c          149 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aattggtgga gactggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcat
      301 ctgatggaat tatgagctac tactcagacg ctatgaagga ccgatttacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaag tgaacaacct gaagttggag gacactgccg
      421 tttattactg tgcgacagcc gactacggta acagccttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005199             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20957:10975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005199
VERSION     KCXD01005199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20957:10975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63681.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       443..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          113 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcggccg
      181 ggggggtccc tgagactctc ctgtgcagtc tctggattca ccttcaatac ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgaatgat
      301 gaaactaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtacga gagacgcatt tggcagcggc tgtgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005200             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:8964:4820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005200
VERSION     KCXD01005200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:8964:4820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63682.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          117 a          144 c          132 g           89 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat gggaaagtag
      301 actacacaca gaagtgccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cacttattac tgtgtgacag
      421 tgggtcccta ccattacttt gactactggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01005201             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13175:7094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005201
VERSION     KCXD01005201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13175:7094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63683.1"
                     /translation="CTTSSWGDDFW"
     D_segment       442..448
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          123 c          145 g          116 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc atcttcgatg actatgccat
      241 gaactgggtc cgccaggctt ctgggaaagg actggagtgg attgcctata ttagaaacaa
      301 gtataacaat tacgcgacag aatacgccgc gtcggtgaag ggcagattca ccatctccag
      361 agatgattca aagaacacgg tatttctgca attgaacagc ctaaaaaccg aggactcggc
      421 cgtctattac tgcaccacct ccagctgggg cgacgacttc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005202             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16202:21829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005202
VERSION     KCXD01005202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16202:21829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..501
     V_segment       143..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63684.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       435..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..501
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          106 a          124 c          157 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 cattaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgacag
      301 tggtggacat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acggctgtct
      421 attactgtgc gagagtggtg ggtggtgccg caggatactt cgacttctgg ggccagggcg
      481 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005203             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17895:16837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005203
VERSION     KCXD01005203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17895:16837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63685.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          118 c          148 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005204             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7890:15729
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005204
VERSION     KCXD01005204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7890:15729"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63686.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       360..368
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       376..410
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           89 a           90 c          128 g          105 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgcgatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagccggag gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtttcta tggcatacac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cagttatttc gaatgatgaa actaagaaat actacgcaga
      241 ctctgtgaag gaccgattca ccatttccag agacaattcc aagaacatgc tatttcttca
      301 aatggacaac ctgaaattgg aggacacggc cgtctattat tgtgtgagag atgatttagg
      361 cagcggctta gggtcctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005205             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15001:16718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005205
VERSION     KCXD01005205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15001:16718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63687.1"
                     /translation="CARVSGRWELFEPGSEDYW"
     D_segment       412..419
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           89 a          136 c          147 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc ttcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gcccccggga agggactgga
      241 gtggattggg tatgtctatg gcggtagcgg tagcacctac tacaacccct ccctcaagag
      301 tcgaatcacc atttcagaag acacgtccaa gaaccagttc tccctgaacc tgaactctgt
      361 gacggccgcg gacacggccg tgtattactg tgcgagagtt tcgggcaggt gggaactatt
      421 tgagcctggg tcagaggact actggggccg gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005206             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15963:7669
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005206
VERSION     KCXD01005206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15963:7669"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63688.1"
                     /translation="CATGRIGSSGWSTLFTGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          148 c          145 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aaggccttga gtggatggga gttgttgatc ctgtcaatgg tgaagaaata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggaa gcagcggctg gtccaccctc ttcaccggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005207             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:26348:13876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005207
VERSION     KCXD01005207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:26348:13876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63689.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       405..416
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..474
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           99 a          139 c          134 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactgctg aagcctttgg agaccctgtc cctcacctgc gctgtttctg
      181 gtggctccat cagcagtaac tactggagct ggatccgcca gtccccaggg aagggactgg
      241 agtggattgg acgtatctct ggtagtggtg ggaacaccgt ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagat ctccatgaaa gtgacctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgacagc cggatatagc agcagcgaaa
      421 gcttctacgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01005208             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:25634:6892
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005208
VERSION     KCXD01005208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:25634:6892"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63690.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          116 c          149 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 gattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggagggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtttctatgg
      241 cttccactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatttcgaa
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tttctagaga
      361 caattccatg aacatgctat ttcttcaaat gaacaacctg aacttggacg acacggccgt
      421 ctattactgt gtgagagatg atttaggcag cggcttaggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005209             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11482:16872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005209
VERSION     KCXD01005209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11482:16872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63691.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       442..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          114 c          158 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ccggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcactgatt tcgtatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tttgtgcgag agttggagag ggtactggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005210             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13606:17810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005210
VERSION     KCXD01005210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13606:17810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63692.1"
                     /translation="CAREWIQWTQLVSGLDSW"
     D_segment       440..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          119 a          110 c          163 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc agatagtgga gtctggagga ggcttggttc
      181 agcctggggg gtcgctgaga ctctcctgtg taggctctgg attcagtttc aaaacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtcatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgactcacc atctccagag
      361 acaattccaa gagtacgcta tatcttcaaa tgaacaacgt gaaattggag gatacggccg
      421 tgtattattg tgcgagggag tggatacagt ggacacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005211             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:19683:18003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005211
VERSION     KCXD01005211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:19683:18003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63693.1"
                     /translation="CARGEYSNSVDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          111 c          156 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagtct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtgaca tcgtatgatg
      301 gaagttggaa gtactacgga gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag aggggaatac agtaactctg ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005212             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8176:3779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005212
VERSION     KCXD01005212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8176:3779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..498
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63694.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       439..444
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          116 c          147 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagaccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgaa ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactatggca
      241 tgcactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt atatcgtacg
      301 atgaaaataa gaaatactac gcagactctc tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctttat cttcaaatga acaacctgaa attggaggac acggccgttt
      421 attactgtgc gaggaggccc tggagtgcag atgcttttga tttctggggc caaggactca
      481 gggtcaccgt ctcttcagcc
//
LOCUS       KCXD01005213             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16519:5857
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005213
VERSION     KCXD01005213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16519:5857"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63695.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       438..458
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          108 c          157 g          125 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagatgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac ctccagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt gacagttata tcgtatgatg
      301 gaagtacgaa gtactatgta gactctgtga aggaccgatt caccatctcc agagacaatt
      361 cgaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgtgag agtagactgt agtggtggtg tctgctactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcgtca gcc
//
LOCUS       KCXD01005214             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16360:8817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005214
VERSION     KCXD01005214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16360:8817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63696.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          122 c          157 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttac tactacatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtctt gccagtggtg
      301 gggatagcac atactatgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgcatctt caaatggaca gcctgagagt tgaagacacg gctgtctatt
      421 actgtgtgag agatcgacgt gttcagtcat tatcctggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005215             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13270:6255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005215
VERSION     KCXD01005215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13270:6255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63697.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          139 c          152 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctgcaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 ggggttcggt agcagtgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005216             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:9127:2695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005216
VERSION     KCXD01005216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:9127:2695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63698.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          107 a          118 c          165 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtg cagccactgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctca ggtattaata
      301 gtggtgggga tggaacatac tacgcagact ccgtgaaggg ccgattcacc atgtccagag
      361 acaactcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005217             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19944:15441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005217
VERSION     KCXD01005217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19944:15441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63699.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       440..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          115 a          114 c          160 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc tgctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtggctttg
      241 gcatacactg ggtccgccag gctcctggga aggggctgga gtgggtgtca cttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ttgtccagag
      361 acaattccaa gaacatggta tatcttcaca tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagtt agtgggcata cagaggggac agttgaaaac tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005218             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4298:6248
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005218
VERSION     KCXD01005218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4298:6248"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63700.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          114 c          158 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtc tttcttcaaa tgagcaacct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005219             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:6828:15998
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005219
VERSION     KCXD01005219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:6828:15998"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63701.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       401..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           91 a          135 c          130 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccaaat gggtcctgtc ccagctacaa ttgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct gtctctggtg
      181 gctctatcag catttactac tggaattgga tccgccaggc cccagggaag ggactggact
      241 ggattggaca tatctatggt agcggtgata gcaccaactt caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagttctc cctgaacctg aggtctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgagcggtcg gcggcagctg gactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005220             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:16054:9207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005220
VERSION     KCXD01005220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:16054:9207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63702.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          134 c          136 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcggc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctagtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005221             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6863:9205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005221
VERSION     KCXD01005221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6863:9205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63703.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          117 c          155 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccac tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagtctctgg gttcaccttc agtggctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggcg gttatatcga
      301 atgatggaac taacaaatac tacgcagact ctctgaagga ccgatttagt atctccagag
      361 agaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tctattactg cgcgacagat gcgtttggta gcgggattga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005222             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:9604:11344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005222
VERSION     KCXD01005222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:9604:11344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..449
     V_segment       104..390
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63704.1"
                     /translation="CASSDYGWFDVW"
     D_segment       395..403
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..449
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           93 a          123 c          128 g          107 t
ORIGIN      
        1 acatggggga tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 atcggaccca ggagtagtga agccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tggcgatagt tataggtgga gctggatccg ccagccccca gggaagggac tggaatggat
      241 tgggtatatt tatggtagta ttacggacac caactacaac ccctccctca aaagtcgagt
      301 caccatttca aaagacacgt ccaagaagca gttctccttg aaactgagct ctgtgaccgt
      361 cgcggacacg gccgtgtatt tctgtgcgag ttcagactac ggttggttcg atgtctgggg
      421 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005223             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14816:14575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005223
VERSION     KCXD01005223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14816:14575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..458
     V_segment       105..393
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63705.1"
                     /translation="CASGGIAATGPDSW"
     D_segment       397..415
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           76 a          141 c          140 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg gatcctgtcc caagtgcagc tgcgggagtc
      121 gggcccggga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggttt ttcggtggta gtcttgggga cccctactac cactcctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaataa ccggttctcc ctgaggctga cctctgtgac
      361 cgccgcggac acggccgttt attactgtgc gagcgggggt atagcagcga ctggtccgga
      421 ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005224             297 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:24599:11431
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005224
VERSION     KCXD01005224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 297)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:24599:11431"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..295
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..295
     V_segment       4..234
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <226..>264
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63706.1"
                     /translation="CGRDDNGVLIDFW"
     D_segment       243..249
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       256..295
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        296..>297
                     /gene="IGHG"
BASE COUNT           76 a           71 c           82 g           68 t
ORIGIN      
        1 acatgggcag cctctggatt caccttcagt acctatggca tgcactgggt ccgccaggct
       61 ccagggaagg ggctggagtg ggtgacagtt atatcgtatg atgaaagtaa gaaatactac
      121 gcagactctc tgaagggccg attcaccatt tccagagaca attccaagaa cacgctatat
      181 cttcaaatga acaacctgca attggaggac acggccgtgt attactgtgg gagagatgat
      241 aatggggtgc ttatcgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005225             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16834:4121
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005225
VERSION     KCXD01005225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16834:4121"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63707.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       438..450
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          115 c          153 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttacta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag tctctggatt caccttcagt agctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtg acatcctatg
      301 atggaagttg gaagtactac ggagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cctgctatat cttcaaatga acagcctgaa attggaggac acggccacat
      421 actactgtgc gagaggggaa tacagtaact ctattgacta ctggggccag ggagtcctgg
      481 tcagcgtctc ctcagcc
//
LOCUS       KCXD01005226             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:26646:16496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005226
VERSION     KCXD01005226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:26646:16496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63708.1"
                     /translation="CVREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          117 c          148 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgtgagggag gagagatttg gctacagttt tgacttctgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005227             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:9452:11513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005227
VERSION     KCXD01005227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:9452:11513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63709.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       440..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          114 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc tattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatgtcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaccct gaaattggag gacacggccg
      421 tgtattattg tgcgagagat gtctttggcg ggggacttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005228             295 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11031:8714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005228
VERSION     KCXD01005228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 295)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 295)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11031:8714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..293
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..293
     V_segment       8..212
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <209..>262
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63710.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       228..235
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       249..293
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        294..>295
                     /gene="IGHG"
BASE COUNT           74 a           73 c           78 g           70 t
ORIGIN      
        1 acatgggacc ttcagtggct atgacatgca ctgggttcgc caggctccag ggaagggtct
       61 agaatgggta tcaggtatta acattggcgg tgacccatac tacccagact ctgtgaaggg
      121 tcgattcacc atctccagag acaacgccaa gaactccttg tatcttcaaa tgaacaacct
      181 gagacctgag gacactgctg tgtattattg tgtgaggggg atggataact accacttcag
      241 taatacggac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005229             434 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6180:11758
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005229
VERSION     KCXD01005229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6180:11758"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..432
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..432
     V_segment       78..371
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>401
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63711.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       377..382
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       386..432
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        433..>434
                     /gene="IGHG"
BASE COUNT           91 a           98 c          140 g          105 t
ORIGIN      
        1 acatgggcag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
       61 taagaggtgt ccagtgtgag gttcagctgg tggagtctgg aggaggcttg ggtcagcctg
      121 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtacc tctggcatgc
      181 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaag tcgcatgatg
      241 gaactaagaa atactacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      301 ccaagaacat gctatatctt gaaatgaaca gcctgaaatt ggaggacacg gccgtgtatt
      361 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      421 ccgtctcctc agcc
//
LOCUS       KCXD01005230             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19151:6845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005230
VERSION     KCXD01005230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19151:6845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63712.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          118 a          141 c          134 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagagt tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagttga gcagcctaag atctgaggac acggccctgt attattgtgc agtcgggtat
      421 agcggccgat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01005231             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13383:13462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005231
VERSION     KCXD01005231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13383:13462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63713.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          144 c          131 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaagcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccga gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01005232             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21542:11474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005232
VERSION     KCXD01005232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21542:11474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63714.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          122 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcatcttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaatca
      301 tggtggggaa agtacatact atgcagactc cgtgaagggc agattcaccc tctccagaga
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005233             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7940:4801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005233
VERSION     KCXD01005233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7940:4801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63715.1"
                     /translation="CSRADIAAAASFDLW"
     D_segment       421..433
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          118 a          142 c          126 g           97 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttcgc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggttcagtc tggggctgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata taccttcact aactactaca tacactgggt gagacaggcc
      241 cctggacaag gccttgagtg gataggactg atctcccctt ataatggtta caaatcggcc
      301 gcacagagcg tccagggcag agtcaccata agtgcggaca tgtccacgag cacaggctac
      361 atggaactaa ccagcctgag atctgaggac acagccgtgt attactgttc gagagcagac
      421 atagcagcgg ctgcctcctt tgacctctgg ggccagggag tcctgctcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01005234             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17772:9627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005234
VERSION     KCXD01005234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17772:9627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63716.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          113 c          153 g          120 t
ORIGIN      
        1 acatgggggg gctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaaca aagaaattct acgcagactc tctgaaggac cgcttcatca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaataacctg aaattagagg acacggccgt
      421 atatttctgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggtgtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005235             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15107:7268
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005235
VERSION     KCXD01005235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15107:7268"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63717.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       418..427
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          118 a          137 c          133 g          107 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccttc gacaactatg gtatcaactg ggtgcgacag
      241 gcccctggac aggggcttga gtggatggga gtaaccatcc cccttgttgg tataatcaac
      301 tacagagaca acgtccagga cagagtcacc atttccgcgg acacgtccac aaacacagcc
      361 tacatggaga taaacagcct gagatctgac gacacggcca tctattactg tgcgagagaa
      421 tattgtactt ctactgattg cgccggattt tttgacttct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005236             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21705:14891
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005236
VERSION     KCXD01005236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21705:14891"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63718.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          143 c          130 g           91 t
ORIGIN      
        1 acatggggga cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctacactggg tgcgacaggc
      241 tcctggaaaa ggacctgagt ggatgggagg tattcaccct gagtatggta aagtagacta
      301 cacacagaag ttccgagaca gagtcaccat catcgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005237             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22178:14018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005237
VERSION     KCXD01005237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22178:14018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63719.1"
                     /translation="CARDVYGRGLDFW"
     D_segment       408..413
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          105 a          101 c          142 g          117 t
ORIGIN      
        1 acatggggag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgttgctatt ttaagaggtg tccagtgtga agtgcagctg
      121 gtggagtctg gaggaggctt ggttcagccg ggggggtccc tgagactctc ctgtgcagcc
      181 tctggattca gcttcagtgg ctttggcatg cactgggtcc gccaggctcc agggaagggg
      241 ctggagtggg tggcagttat atcgtatgat gaaactaaga aatattacgc agactctgtg
      301 aaggaccgat tcaccgtctc cagagacaat tccaagaaca tgctatattt tcaaatgaac
      361 aacctgaaat tggaagacac ggccgtatat tactgtgcga gagatgtcta tggcagggga
      421 cttgacttct ggggcctggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005238             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19663:3561
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005238
VERSION     KCXD01005238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19663:3561"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63720.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          121 a          141 c          137 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtgct tcgatatctg gggccctggc accccgatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01005239             313 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21522:14120
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005239
VERSION     KCXD01005239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 313)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 313)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21522:14120"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..311
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..311
     V_segment       8..250
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <242..>280
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63721.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       260..265
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       269..311
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        312..>313
                     /gene="IGHG"
BASE COUNT           79 a           74 c           88 g           72 t
ORIGIN      
        1 acatgggctg agactctcct gtgcagcctc tggattcacc ttcagtagct ttggcataca
       61 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtatgatga
      121 aactaagaaa tactacgcag actctgtgag ggaccgattc accatctcca gagacaattc
      181 caaaaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtatatta
      241 ctgtgcgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      301 cgtctcctca gcc
//
LOCUS       KCXD01005240             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17726:8179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005240
VERSION     KCXD01005240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17726:8179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63722.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          111 a          142 c          132 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctgttgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgt aaataccttc accgaattgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtg tattactgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005241             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18151:18605
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005241
VERSION     KCXD01005241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18151:18605"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63723.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       443..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          111 c          152 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctt
      121 ttttaagagg tgtccagtgt gaggtgcacc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt agttatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgtaagtaa gaaatactac gcagacgctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cacactatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgg gagagatgat aatggggtgc ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005242             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:10531:14854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005242
VERSION     KCXD01005242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:10531:14854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63724.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       421..427
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          139 c          148 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tactgtatct ggtggagaga
      301 tatacgcaga gaacttccag ggcagagtca ccatgaccga ggacacggcc aaagacacag
      361 cctacatgga gctgaccagc ctgagatctg aggacacggc cgtttattac tgtgcgagag
      421 gtgtgacggc agacgtcttc ggtttcctcg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005243             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18391:18246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005243
VERSION     KCXD01005243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18391:18246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..515
     V_segment       152..443
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63725.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       460..470
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          100 a          156 c          138 g          123 t
ORIGIN      
        1 acatggggag tctccctcac cacccagctg gggatctcag tgcttcattt tctgtccttc
       61 atttctcagt gcttcatttc tgtcctccac cacgatgggg tcaactgcca tcctcgccct
      121 cctcctggct gttctccaag gagtctgtgc cgaggtgcag ctggtgcagt ctggagcaga
      181 ggtgaaaagg cccggggaat ctctgaggat ctcctgtaag acttctggat acagttttac
      241 caattactgg atcagttggg tgcgccagat gcccgggaaa ggcctggagt ggatgggaat
      301 gatctatcct agtgattctg atcccagata cagcccgtcc ttccaaggcc aggtcaccat
      361 ctcagccgac aggtccatca gcaccgccta cctggagtgg ggcagcctga aggcctcgga
      421 caccgccacg tattactgtg cgagagctgg acgctacacc tacagttacc cctttgacta
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005244             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9350:6911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005244
VERSION     KCXD01005244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9350:6911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63726.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       444..450
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          116 a          145 c          138 g           98 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg agggtcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca actggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tcccctgcaa ggcttctgga tacaccctca gcatctctac catcagttgg gtacgacagg
      241 cccctggaca agggcttgag tggatggggg agatcttccc tcttgttggt aaaacaaaat
      301 acgcacagaa gttccacggc agagtcacga ttaccgcgga cacgtccgca agtacagcct
      361 acatggagct gagcggcctg aaatctgagg acacggccgt ctattactgt gcgaaaagag
      421 gtggccacgg taccaccacc acgttgtact tctttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005245             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20838:3099
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005245
VERSION     KCXD01005245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20838:3099"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63727.1"
                     /translation="CARGGNFWSGYSAGALDVW"
     D_segment       425..434
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..488
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          108 a          130 c          154 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccattctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attctccatc cactgggtac gacaggcccc
      241 tggaaagggg cttgagtgga tgggaggtgt tgatcctatg aatggtgaag cagttgcaga
      301 caagttccag ggcagagtca ccatgaccga ggacacgtct gcagacacag cctacatgga
      361 actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgagag gggggaattt
      421 ttggagtggt tattccgccg gggcattgga tgtctggggc cggggagttc tggtcaccgt
      481 ctcgtcagcc
//
LOCUS       KCXD01005246             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:27926:11081
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005246
VERSION     KCXD01005246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:27926:11081"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..418
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63728.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       422..429
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          101 a          138 c          137 g          114 t
ORIGIN      
        1 acatggggag gggtccagct tacatgggaa atgctctctg agagtcatgg acctcctgtg
       61 caagaacatg aagcacctgt ggttcttcct tctcctggtg gcagctccca gatgggtcct
      121 gtcccaggtg cagctgcagg agtcgggccc aggactggtg aagccttcgg agaccctgtc
      181 cctcacctgc gctgtctctg gtgactccat cagcaatagc tactggaact ggatccgcca
      241 gcccccaggg gagggactgg agtggattgg gtatatctct ggtgcttatg ggagcaccag
      301 ctacaacccc tcattcaaga gtcgagtcac catttcaaca gacacgtcca agaaccagtt
      361 ttccctgagg gtgagttctg tgaccgccgc ggacaccgcc ttgtattact gtgtgagata
      421 tgaggatgaa tccattaact accactttga cttctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01005247             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18925:3642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005247
VERSION     KCXD01005247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18925:3642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63729.1"
                     /translation="CARGRFGSSVWSNLVYGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          139 c          153 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgccctc
      121 tctgaggtcc aactggtgca gtctggggct gaggtgagga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggttggga ggtgttgatc ctgcaaatgg tgaggtaata
      301 cacgcagata gttttcaggg cagagtcacc atgaccgagg acacgtctac actcacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 cggttcggta gcagcgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agtc
//
LOCUS       KCXD01005248             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10418:20603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005248
VERSION     KCXD01005248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10418:20603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..344
     V_segment       8..269
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <263..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63730.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       283..289
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..344
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           81 a           87 c           99 g           79 t
ORIGIN      
        1 acatggggtg aagaagcctg gggcctcagt gaaggtctcc tgtaaggttt ccggatacac
       61 cttcaccgaa ttatccatgc actgggtgcg acaggcccct ggaaaagggc ttgagtggat
      121 gggaagtgtt gatcctgttt ttggtgaaat aatgaattca gagaagttcc agggcagagt
      181 cgccttgacc gaggacacgt ctacagacac agcctacatg gagttgagca gcctgagatc
      241 tgaggacacg gccgtgtatt actgtgcgac atcatccagc ggcacctggc tatattggta
      301 cttcgatgtc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01005249             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13986:15637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005249
VERSION     KCXD01005249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13986:15637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63731.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          114 c          158 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga gtctcctgtg cagcctctgg attcaccttc agtactagcg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggct gttgaatcgc
      301 atgatggaaa taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gatacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005250             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18401:4599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005250
VERSION     KCXD01005250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18401:4599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63732.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       405..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           99 a          135 c          137 g          108 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aggccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtggctcctt cagcggtttc tattggagct ggatccgcca gtccccaggg aagggactgg
      241 agtggattgg gtatatcagt gctagtagtg ggagtaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca ataaccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga gaaatactat agtggtagtt
      421 ataaacacaa ctggttcgat gtctggggcc cgggagtcca ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005251             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9575:7939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005251
VERSION     KCXD01005251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9575:7939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63733.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          119 c          156 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgt caggctccag ggaaggggct ggagtggatc tcaagtattg acagtggtgg
      301 gactaccaca aattatgcag actccgtgag gggcagcttc accatctcca gagagaacgc
      361 caagaacaga ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcgcgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005252             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7271:10822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005252
VERSION     KCXD01005252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7271:10822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63734.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       422..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          112 a          141 c          138 g          100 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgatag
      301 acgcagaaaa tttccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagcctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcaa ttggcttttt tggtacttcg atttttgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01005253             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21074:20835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005253
VERSION     KCXD01005253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21074:20835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..342
     V_segment       8..270
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63735.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       280..297
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..342
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           79 a          101 c           93 g           71 t
ORIGIN      
        1 acatgggggt gaaaaggccc ggggaatctc tgaggatctc ctgtaagact tctggataca
       61 gcttcaccaa ttactggatc agttgggtgc gccagatgcc cgggaaaggc ctggagtgga
      121 tgggaatgat ctatcctagt gattctgatc ccagatacag cccgtccttc caaggccagg
      181 tcaccatctc agccgacaag tccatcagca ccgcctacct gcagtggagc agcctaaagg
      241 cctcggacac cgccacgtat tactgtgcga gagctggacg atacacctac agttacccct
      301 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005254             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12491:11196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005254
VERSION     KCXD01005254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12491:11196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63736.1"
                     /translation="CARADRGSSIDFW"
     D_segment       439..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          115 c          146 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aagactcacc atgaagtttg ggctgagctg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct aagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatgc
      241 actgggtccg ccaggctcca gggcaggggc tggagtgggt ggcggttata tcttatgatg
      301 atgataagaa atactacaca gactctttga aggaccgatt caccatatcc agagacaatt
      361 ccaagaacac tctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag agcggatcgc ggcagttcaa ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005255             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:10980:14738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005255
VERSION     KCXD01005255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:10980:14738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..498
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63737.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       441..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          118 c          149 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcaa
      121 ttttaagagg tgtccagtgt gaggtacagc tggtggagtc tggaggaggc tcggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtttg
      301 atggagaaaa gaaaatctac gcagactctg tgaaggaccg aatcaccatt tccagagacg
      361 attccaagaa cacgctatat cttcaaataa acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagacgccct tggaacgctg actactttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005256             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24276:9590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005256
VERSION     KCXD01005256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24276:9590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63738.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       415..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          115 a          137 c          143 g          102 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgcggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg gttcaccttt agcaccgaag ccatcaattg ggtgcgacag gcccctggac
      241 aaggacttga ctggatggga ggggtcatcc ctcttatggg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg tttaccgcgg acacgtccat aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggccg tgtattattg tgcgaaatcc gtgaattacg
      421 aggaagataa cggttactat ataccgacgc agtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01005257             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:6207:4087
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005257
VERSION     KCXD01005257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:6207:4087"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63739.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          110 a          142 c          136 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtggtgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtg tattattgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005258             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15258:18555
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005258
VERSION     KCXD01005258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15258:18555"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    80..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        80..458
     V_segment       80..373
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <365..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63740.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       382..389
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..458
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           99 a          119 c          148 g           94 t
ORIGIN      
        1 acatggggga cagcacctca ccatggactg gacctggagg atcctcctct tggtggcagc
       61 agctacaggc gcccactctg aggtccaact ggtgcagtct ggggctgagg tgaagaagcc
      121 tggggcctca gtgaaggtct cctgcaaggt ttccggagac accttcaccg aattatccat
      181 gcactgggtg cgacaggccc ctggaaaagg gcttgagtgg atgggaggtg ttgaccctgc
      241 aaatggtgaa ataatacacg cagatagttt ccagggcaga gtcaccatga ccgaggacac
      301 gtctacagac acagcctaca tggagctgag cggcctgaga tctgaggaca cggccgtgta
      361 ttactgtgcg agaggggggt tcggtagcag tgtctggtcc aatctcgtct atggtttgga
      421 ttcctggggc caaggggtcg ccgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005259             408 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18978:7543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005259
VERSION     KCXD01005259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 408)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 408)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18978:7543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    46..406
                     /note="immunoglobulin heavy chain variable region"
     V_region        46..406
     V_segment       46..336
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <328..>375
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63741.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       343..354
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       358..406
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        407..>408
                     /gene="IGHG"
BASE COUNT           83 a          107 c          120 g           98 t
ORIGIN      
        1 acatgggggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt gcagctggtg
       61 gagtctgggg gcggcttggc aaagcctggg ggatccctga gcctctcctg tgtagcctct
      121 ggattcacct tcagtaccta ttccatacac tgggtccgcc agactccagg gaaggggctg
      181 gagtgggtct ccgctattag tactgctggt agcacatact acacagactc cgtgaagggc
      241 cgattcacca tctccagaga caactcacag aacacgctct ccctgcaaat gaacagcctg
      301 agagctgagg acacggccct gtattactgt gcgaaagggg agacagcttc agtttattac
      361 ggtttggatt cctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01005260             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19724:20146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005260
VERSION     KCXD01005260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19724:20146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63742.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          122 c          147 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaggt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtt cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcatctt caatacctat
      241 gccatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 catgatggaa ctaagacata ctacacagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacattca atatcttcac atgaacaacc tgaaattgga ggatacggcc
      421 acatactact gtgcggcctc ctacttgggg tacggatttg agtactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005261             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10574:15073
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005261
VERSION     KCXD01005261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10574:15073"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..463
     V_segment       112..401
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63743.1"
                     /translation="CAGGAYANLDYW"
     D_segment       412..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          101 a          117 c          141 g          106 t
ORIGIN      
        1 acatgggcca cagtgttcca ttcggtgatc agcactgaac acagaggact caccatggag
       61 tctgggctga actgggtttt ccttgttgct attttaagag gtgtccagtg tgaggtgcaa
      121 atggtggagt ctgggggcgg cttggcaaag cctggggggt ccctgagact ctcctgtgca
      181 gcctctggat tcaccttcag tagatactgg atgaactggg tccgccaggc tccaggaaag
      241 gggctggagt gggtctcagc tcttaattat gatggggata gtacatacta cgcagactcc
      301 gtgaagggtc gattcaccat ctccagagac aactcaaaga acacgctctc cctgcaaatg
      361 cacagcctga gagaggatga cacggccgta tatttctgtg cgggcggggc gtacgctaac
      421 ctcgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005262             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:4090:13438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005262
VERSION     KCXD01005262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:4090:13438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63744.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          113 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacaccctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005263             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:23680:11112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005263
VERSION     KCXD01005263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:23680:11112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..226
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63745.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       230..237
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       252..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           68 a           83 c           80 g           67 t
ORIGIN      
        1 acatgggggt gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa
       61 gggactggag tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc
      121 cctcaagagt cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct
      181 gagttctgtg accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc
      241 cattaactac cactttgact gctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005264             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10043:11839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005264
VERSION     KCXD01005264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10043:11839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63746.1"
                     /translation="CATAGYSSRESFYGLDSW"
     D_segment       401..411
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          140 c          135 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctgctgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggaa caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagatctcc ctgaaagtga cctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gacagccgga tatagcagca gggaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005265             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19210:9366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005265
VERSION     KCXD01005265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19210:9366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..470
     V_segment       89..382
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63747.1"
                     /translation="CARVVYYDSSYSTSPYNRFDVW"
     D_segment       399..407
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          101 a          128 c          140 g          103 t
ORIGIN      
        1 acatgggggc ctgggaacac agctcatcac catggacttg acctggaggc tcctctttgt
       61 ggtggcagca gctacaggtg cccagtccca ggtccagctg gtgcagtccg gggctgaggt
      121 gaagaagcct ggggcctcag tgaagctctc ctgcaaggct tctgggtaca ccttcagcat
      181 ctatgccatc agttgggtgc gacaggcccc tgggcaaggg cttgagtgga tgggagggat
      241 catccctctt gttggtataa caaattacgc acagaggttc cagggcagag tcaccattac
      301 cgcggacacg tccacaagca cagcctacat agacctgagt agcctgagat ctgaggacac
      361 ggccgtgtat tactgtgcga gagttgtata ctatgatagt agttattcca cgagtcccta
      421 caaccggttc gatgtctggg gcccgggagt cctagtcacc gtctcctcag cc
//
LOCUS       KCXD01005266             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:19796:11918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005266
VERSION     KCXD01005266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:19796:11918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63748.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          111 c          160 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag ggtccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaag taggacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtg tatgttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005267             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12780:5735
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005267
VERSION     KCXD01005267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12780:5735"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63749.1"
                     /translation="CAKAGDDDYGHYSFDYW"
     D_segment       447..465
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          118 a          119 c          151 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gggttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 ggttacactg ggtccgccag gctccaggga aggggctgga ttgggtaaca gttatatcgt
      301 atgatggaac taagaaatac tacgcagact ctgtgcagga ccgattcacc atctccagag
      361 acaattccaa gaacattcta tatcttcaaa tgaacaacct gaaattggcg gacacggccg
      421 tgtattactg tgcgaaagca ggcgacgatg attacggtca ctattccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005268             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22198:10289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005268
VERSION     KCXD01005268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22198:10289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63750.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       431..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          124 c          149 g          107 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcggcc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacagtg tcaccgaatt atcgcttcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgtaaaa ggtgaagaaa
      301 ttcacggaga ggagttccag gacagagtca ccatgaccga ggacccgtct acagacacag
      361 cctacatgga gttgagcaac ctgagatctg aggacacggc cgtgtattat tgtgcgagtg
      421 ggtttagtat ctggttattt tatgacgttt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005269             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21192:13441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005269
VERSION     KCXD01005269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21192:13441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63751.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          114 a          143 c          128 g           92 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt gttcatcctg aatatggtaa agtagactcc
      301 atacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga gacagtctac
      361 atggacctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005270             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17550:14792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005270
VERSION     KCXD01005270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17550:14792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63752.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          150 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005271             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22304:19588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005271
VERSION     KCXD01005271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22304:19588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63753.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       407..413
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           83 a          138 c          140 g          105 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagttcccag atgggtcctg tcccaggtgc ggctgcagga
      121 gtcgggccca ggacttgtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggttact actggggctg gatccgccgg cccccagggg agggtctgga
      241 gtggattggg tatatcagtg ggagtggtgg gagttccgac tacaagtcct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagtc cggggcgtaa ctatccacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005272             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22365:12616
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005272
VERSION     KCXD01005272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22365:12616"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63754.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       408..414
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           89 a          136 c          139 g          103 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagttccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggacttgcg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tactggggct ggatccgcca gcccccaggg gaggggctgg
      241 agtggattgg gtatatcagt gggagtggtg ggagtaccga ctacaagtcc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgaaa ctgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagagt ccggggcgta actatccact
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005273             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7840:4748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005273
VERSION     KCXD01005273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7840:4748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63755.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          110 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agttagggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagtaatg
      241 gcatgcactg ggtccgccag gttccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgttctactg tgtgagagac tcttatggga gtggtttgga tgcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005274             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:13443:4848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005274
VERSION     KCXD01005274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:13443:4848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..503
     V_segment       124..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63756.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       425..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>507
                     /gene="IGHG"
BASE COUNT          119 a          139 c          144 g          105 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg attcacgttc agcaccgatg ccatcagttg ggtgcgacag
      241 gcccctggac aagggcttga ttggatggga ggggtcatcc ctcttatggg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg tttaccgcgg acacgtcact aagcacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattattg tgcgaaatcc
      421 gtgaattacg aggaagataa cggttactat ataccgacgc agtttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctctgcc
//
LOCUS       KCXD01005275             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21280:10709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005275
VERSION     KCXD01005275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21280:10709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63757.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       444..450
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          146 c          141 g          100 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgatgaa gcctggggcc tcagtgaagc
      181 tctcctgcaa ggcttctgga tacaccctca gcatctctgc catcagttgg gtacgacagg
      241 cccctggaca agggcttgag tggatgggag agatcttccc tcttgttggt gtgacaaaat
      301 acgcacagaa cttccagggc agagtcacga ttaccgcgga cacgtccaca agcacagcct
      361 acatggagct gcgcggcctg agatctgagg acacggccgt atattactgt gcgagaagag
      421 gtggccacgg taccaccacc acgttgtact tctttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005276             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12699:4187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005276
VERSION     KCXD01005276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12699:4187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..488
     V_segment       137..429
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63758.1"
                     /translation="FSRDRQKEIDFR"
     D_segment       430..434
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          126 c          145 g          109 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aagtgtgagg tgcaactggt ggagtctggg ggagacttgg tccagcctgg
      181 agggtccctg agactctcct gtgcagcctc tggattcacc ttcagtcgtt ccgacatgac
      241 ctgggtccgc caggctccgg gaaaggggct ggagtgggtc tcatatatta cttacacgga
      301 aaaaaccata aactacgctg actccgtgaa gggccgattc accatctcca gagacaacgc
      361 caagaagtcg ctgtctctgc aaatgagcag cctcagagcc gaggacgcgg ccgtgtgttt
      421 ctttagtaga gatcgtcaaa aagagattga cttccggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01005277             348 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19753:6990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005277
VERSION     KCXD01005277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 348)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 348)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19753:6990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..346
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..346
     V_segment       6..279
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <274..>315
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63759.1"
                     /translation="CAATGEPLEYFDFW"
     D_segment       288..292
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..346
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        347..>348
                     /gene="IGHG"
BASE COUNT           71 a          100 c          103 g           74 t
ORIGIN      
        1 acatggggcc caggagtggt gaggccttca gagaccctgt ccctcacctg cgctgtctct
       61 ggaggatcta tcagcagtgg ttatgactgg agctggatcc gccagccccc agggaagggg
      121 ctggagtgga ttgggtatat ctatggtact agtgggagca ccaactacaa tgcgtccctc
      181 aagaatcgag tcaccatttc aaaagacgcg tccaagaacc agttctccct gcagttgagg
      241 tctgtgaccg ccgcggacac ggccgtttat tactgtgcgg cgacagggga accccttgaa
      301 tacttcgact tctggggcca gggcgccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005278             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14010:8766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005278
VERSION     KCXD01005278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14010:8766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63760.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       421..428
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          137 c          152 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcgc
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgaccctgca aatggtgaaa taatacacgc
      301 agatagtttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gaggggggtt
      421 cggtagcagt gtctggtcca atctcgtcta tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005279             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15053:9822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005279
VERSION     KCXD01005279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15053:9822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63761.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       440..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          115 c          150 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaatacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtttgatg
      301 aaagtaagaa atactacgcc gactctttga aagaccgatt caccatatcc agagacgact
      361 ccaggaacat gctatatctt caactgaaca acctgaaatt ggacgacacg gccgtgtatt
      421 actgtgcgag agatgtgtat ggctgggggc ttgactactg gggccaggga gtcctagtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005280             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23363:7695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005280
VERSION     KCXD01005280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23363:7695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63762.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          116 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaga caagagatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gatattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01005281             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7681:19406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005281
VERSION     KCXD01005281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7681:19406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63763.1"
                     /translation="CSRYIPGTTVFDYW"
     D_segment       402..411
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           91 a          142 c          124 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggaggcag ctgccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtacctact gggcctggat ccgccagccc cccgggaagg gactggagtg
      241 gattggctat atctatggtg gtactgagag taccggctac aacccctccc tcaagagccg
      301 ggtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaacctga ggtctattac
      361 cgccgcggac accgccattt atttctgttc gagatacata cctggaacaa cggtctttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005282             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:6374:8931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005282
VERSION     KCXD01005282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:6374:8931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63764.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          153 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc tacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggttc atctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacgtcct
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gagcctgcta tatcttcaaa tgaacaacct gaacttggag gacacggccg
      421 tttattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005283             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12502:19909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005283
VERSION     KCXD01005283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12502:19909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63765.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       412..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          111 a          143 c          129 g           91 t
ORIGIN      
        1 acatgggaca caaccaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggct cctcctcttg gtggcagcag ctacaggcgc ccactccgag
      121 gtccagctgg tacagtctgg ggctgaggtg aagaagcctg gggcctccgt gaaaatctcc
      181 tgccaggctt ctggatacac cttaaccgac cactacctgc actgggtgcg acaggctcct
      241 ggaaaaggac ttgagtggat ggcaggtgtt catcctgaat atggtaaagt ggactacaca
      301 cagaggttcc gagacagact caccatcacc gcggacatgt cgacagagac agcctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtttatt attgtgtgac agtgggtccc
      421 taccattact ttgactactg gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005284             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10627:15629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005284
VERSION     KCXD01005284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10627:15629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63766.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       415..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          112 a          139 c          145 g          101 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga accctggtgc ctcagtgaag ctctcctgca
      181 agggttctgg attctccctc agcaccgagg ccatcagttg ggtgcgacag gcccctggac
      241 aaggacctga ctggatggga gggatcatcc ctctcgtggg tgcaacaaac tacgcacaga
      301 agttccaggg cagagtcaag tttaccgcgg acacgtccat aaacacagcc tacatggaac
      361 tgagcggcct gagatctgag gacacggccg tgtattattg tgcgaaatcc gtgaattacg
      421 aggaagataa cggttactat ttaccgacgg ggtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01005285             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21116:11850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005285
VERSION     KCXD01005285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21116:11850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63767.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       434..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          113 c          156 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttctattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gctgttattt
      121 taagaggtgt ccagtgtgac gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcaggtt ctggattcac cttcagtaac tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt ggctgttatg tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caagtgaaca ccctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcttt ggcgggggac ttgactactg gggccaggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005286             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11569:21596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005286
VERSION     KCXD01005286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11569:21596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63768.1"
                     /translation="CARYGDDDYSGNDYFFDFW"
     D_segment       410..419
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          137 c          132 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtagctact ggaattggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggtac atctatggtg ctactgggag caccagctac aacccctccc tcaagagtct
      301 agtcagcatt tcaacagaca cgtccaagaa ccagttttcc ctgaacctga actctgtaac
      361 cgccgcggac accgccgtgt attactgtgc gagatatggc gacgatgact atagtgggaa
      421 tgattacttc tttgacttct ggggcctggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005287             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6569:4464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005287
VERSION     KCXD01005287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6569:4464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63769.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       416..423
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          101 a          137 c          144 g           97 t
ORIGIN      
        1 acatggggaa ccacctccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acctgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaaa ctctcctgca
      181 aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcgtcc cgcttgttgg aacaacaaac tccgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccat aagcacagtc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagaggc ctgggtagca
      421 gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005288             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14535:6043
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005288
VERSION     KCXD01005288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14535:6043"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..478
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63770.1"
                     /translation="CAIGPSGNWIHWSFDVW"
     D_segment       413..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>482
                     /gene="IGHG"
BASE COUNT          106 a          148 c          135 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcccggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaact gtccatgcac tgggtgcgac
      241 aggcccctgg aaaaggactt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 tgttccaggg cagagtcaca atgaccgagg acacgtctac agacacagcc tacatggagc
      361 tgagcagcct gacacctgac gacacggccg tctattactg tgcgattggc cctagcggca
      421 actggatcca ctggtccttc gatgtctggg gccctggcac cccaatcacc atctcctcgg
      481 cc
//
LOCUS       KCXD01005289             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20315:6123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005289
VERSION     KCXD01005289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20315:6123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63771.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       409..413
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           88 a          141 c          131 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gcgccatcag cagtggtttc tactggacct ggatccgcca acccccaggg aaggggctgg
      241 agtggattgg gtgtatcggt ggtaatagtg gtaccaccta ctaccacccc tccctcaaga
      301 gtcgagccac catttcaaaa gacacgtcca gcaatcaact ctccctgaag ctgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga tgaagacccc tccatttttg
      421 actactgggg ccagggcgtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005290             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:24090:17935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005290
VERSION     KCXD01005290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:24090:17935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63772.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       432..440
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          125 c          149 g          104 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctccccc acagaagccc cagagcaaag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcggc
      121 cactctgagg tccagttggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacagt gtcaccgaat tatcgattca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg atcctgtaaa aggtgaagaa
      301 attcacggag aggagttcca ggacagagtc accatgaccg aggacccgtc tacagacaca
      361 gcctacatgg agttgagcaa cctgagatct gaggacacgg ccgtgtatta ttgtgcgagt
      421 gggtttagta tctggttatt ttacgacgtt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005291             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22925:13859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005291
VERSION     KCXD01005291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22925:13859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63773.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       424..431
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          139 c          151 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggag acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgaccct gcaaatggtg aaataataca
      301 cgcagatagt ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcggcctga gatctgagga cacggccgtg tattactgtg cgagaggggg
      421 gttcggtagc agtgtctggt ccaatctcgt ctatggtttg gattcctggg gccaaggggt
      481 cgccgtcacc gtctcctcag cc
//
LOCUS       KCXD01005292             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22490:18452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005292
VERSION     KCXD01005292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22490:18452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..509
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63774.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       448..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          101 a          131 c          156 g          123 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gacctgggtt ttccttgctg cttttttaaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctgggggg gccttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttt ggtgattgtg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagta agactggtga
      301 aaccgaatac tacactgact ccgtgaaggg ccgattcacc atctccagaa acaacgccga
      361 gaactcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg tgtattactg
      421 cactagaatt tgttgtcccc gtgattttag cagcgactgt cactggttcg atgtctgggg
      481 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005293             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12152:19179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005293
VERSION     KCXD01005293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12152:19179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63775.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       437..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          112 c          155 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcac tttggcttac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgcatgatg
      301 gaaataagat atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 cgaagaacat ggtatatctt gaaatggaca acctgcaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgcctac ggtaccgggt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005294             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16057:15623
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005294
VERSION     KCXD01005294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16057:15623"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63776.1"
                     /translation="CARDRFMGIGALGYW"
     D_segment       398..402
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           88 a          132 c          144 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgaag tctctggtgg
      181 ctccatcagc ggtggttatg gctggacctg gatccgccag gccccaggga agggactgga
      241 gtgggttggg agaatgtatg gtagcagtgg tagcacctac tacaacccct ccctcaaggg
      301 tcgagtcacc atttcaaaag acacgtccaa gatccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tttattattg tgcgagagat aggttcatgg gcataggggc
      421 tctcggctac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005295             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21256:11727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005295
VERSION     KCXD01005295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21256:11727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63777.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          138 c          130 g          108 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggcga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccgtc accagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaggag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005296             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17140:16702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005296
VERSION     KCXD01005296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17140:16702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63778.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          122 c          153 g          126 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtactagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgac aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005297             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15742:22493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005297
VERSION     KCXD01005297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15742:22493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63779.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       414..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          140 c          127 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcttggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggc ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg ggctggagtc
      241 gattgggtat atctctggtg cttatgggag taccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccagttttcc ctgaggctgg cttctgtgac
      361 cgccgcggac accgccgttt attactgtgt gagatatgag gacgaatcca taaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005298             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:20025:10752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005298
VERSION     KCXD01005298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:20025:10752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63780.1"
                     /translation="CARDVYGRGFDYW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          113 c          155 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgt
      121 tattttaaga ggtgtccagt gtgaagtaca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccgtca gtaactttgg
      241 cgttcactgg gtccgccagg ctccagggaa ggggctggac tgggtgacag tgatatcgta
      301 tgatggaaat aagaaatact acgcagagtc tgtgaagggc cgattcacca tctccagcga
      361 cacttccaag aacgtggtat atcttcaaat gaacaacctg aaattggcgg acacggccgt
      421 gtattactgt gcgagagatg tttacggtag gggatttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005299             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12147:5815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005299
VERSION     KCXD01005299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12147:5815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63781.1"
                     /translation="CVRDAYGGGWDSW"
     D_segment       444..452
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          105 a          115 c          154 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggcaggggc tggagtgggt ggcggttata tcgtttgatg
      301 atagtaagaa atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatatctt cagatgaaca acctgaaatt ggaggacacg gccctttatt
      421 actgtgtgag agatgcttac ggtggtggct gggactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005300             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9289:6173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005300
VERSION     KCXD01005300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9289:6173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63782.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       407..414
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           93 a          135 c          137 g          112 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac cccctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctgga
      181 ggctctctca gcggtggtta tgactggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg gctatatcta tggtggtagt gggagcacca cctacaaccc gtccctcagg
      301 aatcgagtca ccatttcaaa agacacgtcc aagaaccagt tgtccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtatattat tgtgcgagac agtgctgtta ctatgatgac
      421 tttttagact actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005301             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12977:7848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005301
VERSION     KCXD01005301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12977:7848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63783.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          112 a          141 c          136 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaagacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatatgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01005302             347 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18747:7552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005302
VERSION     KCXD01005302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 347)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 347)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18747:7552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..345
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..345
     V_segment       6..275
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <267..>314
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63784.1"
                     /translation="CAKGETATPYYGLDSW"
     D_segment       282..290
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       293..345
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        346..>347
                     /gene="IGHG"
BASE COUNT           79 a           97 c           99 g           72 t
ORIGIN      
        1 acatgggggg cggcttggca aagcctgggg gatccctgag actctcctgt gcagcctctg
       61 gattcacctt cagtacctat gctatacact gggtccgcca ggctccaggg aagggactgg
      121 agtgggtctc agctattagc actggtggta ggacattcta cgcagactcc gtgaagggcc
      181 gattcaccat ctccagagac aactcaaaga acacgctctc cctgcaaatg aacagcctga
      241 gagctgagga cacggccatg tattactgtg cgaaagggga aacagctaca ccttactacg
      301 gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005303             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8932:7600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005303
VERSION     KCXD01005303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8932:7600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..416
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63785.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       418..424
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..483
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           95 a          120 c          153 g          117 t
ORIGIN      
        1 acatgggggc cccagaattc ccaggtgttt ctgttcggcg atcagcacta aacacagaac
       61 ataccatgga gtttgtgctg agctgggttt tccttgttgc tcttttgaaa ggtgtccagt
      121 gtgaggtgca gctggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
      181 tctcctgcgc agcctctggt ttcagcttca gtttctacta tatgacctgg gtccgccagg
      241 ctccagggaa ggggctggag tggatctcag gtattgacac tggtggggat agcacctact
      301 atgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag aagacactgt
      361 atcttcagat ggacagcctg agagctgagg acacggctgt ctattactgt gcgagagtag
      421 tgggtggtgc cgccggatac ttcgatttct ggggccaggg cgccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005304             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9833:5788
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005304
VERSION     KCXD01005304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9833:5788"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..483
     V_segment       120..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63786.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       422..429
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..483
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          103 a          136 c          146 g          100 t
ORIGIN      
        1 acatggggga taacaaccac gtccctcctc taaagaagcc cctgggaaca cagctcatca
       61 ccatggactt gacctggagg ctcctctttg tggtggcagc agctacaggt gcccagtccc
      121 aggtccagct ggtgcagtcc ggggctgatg tgaagaagcc tggggcctca gtgaagctct
      181 cctgcaaggc ttctggattc gccttcagaa tgtatgccct cagttgggtg cgacaggccc
      241 ctggacaagg gcttgagtgg atgggaggga tcgtccctct tgttggaaca acaaactccg
      301 cacagaagtt ccagggcaga gtcacgatta ccgcggacac gtccacaagc acagtctaca
      361 tggagttgag cagcctgaga tctgaggaca cggccatgta ttactgtgcg agaggcctgg
      421 gtagcagcgc ccactttggt ttggattcct ggggccaagg ggtcgtcgtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005305             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21176:3225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005305
VERSION     KCXD01005305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21176:3225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63787.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          114 a          141 c          130 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagttggtac agtctggggt tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc cagtcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01005306             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17155:16732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005306
VERSION     KCXD01005306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17155:16732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63788.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          113 c          146 g          123 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 caacacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtaagtttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acgcaaactc tgtgaagagc cgattcacca tctccagaga
      361 caattccaag aacatacttt atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005307             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16984:17645
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005307
VERSION     KCXD01005307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16984:17645"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63789.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          117 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgtgct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga ctgggtggca gttatttcgt
      301 atgatgaaac taagaaatac ttcgcagact ctgtgaggga ccggttcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cggggtttga cttctggggc cagggagccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005308             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13732:8535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005308
VERSION     KCXD01005308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13732:8535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63790.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       445..451
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          111 c          151 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctgtt
      121 ttaagaggtg tccagtgcga ggtgcagctg gtggagtctg gaggagactt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa ctatggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtctgat
      301 ggaagtaaga catactacgc aaactctgtg aaggaccgat tcaccatatt aagagacaat
      361 tccaagaata tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtctat
      421 tactgtgcga gagacgattt gggaagtggc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005309             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17352:15383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005309
VERSION     KCXD01005309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17352:15383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63791.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       435..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          111 a          135 c          150 g          106 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccaa ctggtggagt ccggggctga ggtgaagaag cctggggcct cagcgaagct
      181 ctcctgcaag gccgctggat acattttcag tacctctgcc atcagttggc tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggggg gatcatgcct cttgttggta gaacaaacta
      301 cgcacagagg ttccagggca gagtcacgat taccgcggac acgtccacaa ggacagccaa
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattattgtg cgagcggtgg
      421 tttccaggat gagaacggtt actattttcc agactatttt gacttttggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005310             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10755:6550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005310
VERSION     KCXD01005310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10755:6550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63792.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       445..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          111 c          153 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcttctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgcctgg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg aaattgaagg acacggccgt
      421 gtactactgt gggagagatg ataatggggt gattatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005311             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5663:11347
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005311
VERSION     KCXD01005311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5663:11347"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63793.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          106 a          145 c          136 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gccccaggaa gaggccttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgta tattactgtg cgatcggccc tagcggcagt
      421 tggaacgcct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005312             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4918:9691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005312
VERSION     KCXD01005312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4918:9691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63794.1"
                     /translation="CAKSRSSSLHWDFDFW"
     D_segment       436..442
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..498
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          130 c          150 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggaatctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtcggg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca ggtaaggggc tggagtgggt ctcagctatg agtgttgctg
      301 gaagcacata ctacgcaggc tccgtgaagg gccgattcac cgtctccaga gacaactcaa
      361 agaacatgtt ctccctgcaa atggacaacc tgacacctga ggacacggcc gtgtattact
      421 gtgcgaaaag tcggagtagt agccttcact gggacttcga tttctggggc cctggcaccc
      481 caatcacaat ctcctcagcc
//
LOCUS       KCXD01005313             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9218:10276
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005313
VERSION     KCXD01005313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9218:10276"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..444
     V_segment       69..362
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63795.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       379..390
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT           95 a          116 c          143 g           92 t
ORIGIN      
        1 acatggggac catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg
       61 cccagtccca ggtccagctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag
      121 tgaagctctc ctgcaaggct tctggataca ccttcagcat ctatgtcatc aattgggtgc
      181 gacaggcccc tggacaaggg ctagagtgga tgggagggat catccctctt gttggtacaa
      241 caaactacgc acagaggttc cagggcagag tcacgattat tgcggacccg tccacaagca
      301 cagcctacat ggaattgaga agcctgagat ctgaggacac ggccgtgtat tactgtgcga
      361 gaggcccccc tactgaaggg ggtgattatt ctgggggggc tttgagccga tggggccagg
      421 gagtccaggt caccgtctcc tcagcc
//
LOCUS       KCXD01005314             304 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18585:22457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005314
VERSION     KCXD01005314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 304)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 304)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18585:22457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..302
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..302
     V_segment       8..232
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <224..>271
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63796.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       252..259
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       260..302
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        303..>304
                     /gene="IGHG"
BASE COUNT           68 a           86 c           81 g           69 t
ORIGIN      
        1 acatggggtc tctggtgact ccatcagcag tagctactgg aactggatcc gccagccccc
       61 agggaaggga ctggagtgga ttgggtatat ctctggtgct tatgggagca ccagctacaa
      121 cccctccctc aagagtcgag tcaccatttc aacagacacg tccaagaacc agttttccct
      181 gaggctgagt tctgtgaccg ccgcggacac cgccgtgtat tattgtgtga gatatgagga
      241 cgaatccatt aactaccact ttgactactg gggccaggga gtcctggtca ccgtctcctc
      301 agcc
//
LOCUS       KCXD01005315             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5441:13915
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005315
VERSION     KCXD01005315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5441:13915"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63797.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..412
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           85 a          142 c          134 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcgggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttactt ctggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattggct ttgtcagtgg tagtggtcgg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaatct gatttctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgcgagtcc ggggcgtaac tatacactac
      421 tttgactact ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01005316             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20005:10723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005316
VERSION     KCXD01005316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20005:10723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63798.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       270..276
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           72 a           82 c           99 g           69 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcggcctct ggattcacct tcagtaccta
       61 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cggttacatc
      121 gaatgatgaa agtaacaaat actacgcaga ctctgtgaag ggccgcttca gcgtctccag
      181 agacaattcg aagagcatgc tatatcttca catgaacaac atgaaattgg acgacacggc
      241 cgtgtattac tgtgcgacgg atgcgtttgg cagcgggatt gaccactggg gccagggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005317             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12307:17378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005317
VERSION     KCXD01005317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12307:17378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63799.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       406..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          137 c          131 g          105 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tacatctatg gtagtactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcgcc atttcaacag acacgtccaa gaatcagttc tccctgaaac tgaactctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat ggagatgata gtgttcatta
      421 caactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005318             326 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22060:14515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005318
VERSION     KCXD01005318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 326)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 326)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22060:14515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..322
     V_segment       8..248
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>293
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63800.1"
                     /translation="CARVSGIAESSVEYFEFW"
     D_segment       255..264
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..322
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>326
                     /gene="IGHG"
BASE COUNT           79 a           82 c           87 g           78 t
ORIGIN      
        1 acatggggag actctcctgt gcagcctctg gattcacctt cagtagctat ggcttccact
       61 gggtccgcca gtctccaggg gaggggctgg aatgggtggc acttatatcg tatgatggaa
      121 ctaagaaata ctacgcagac tctatgaagg accgattcac catctccaga gacaattcca
      181 agagcatgct atatcttcaa atgatcaacc tgaaattgga ggacacggcc gtctattact
      241 gtgcgagagt aagcggtata gctgaaagtt ccgttgaata cttcgagttc tggggccagg
      301 gcgccctggt caccgtctcc tcggcc
//
LOCUS       KCXD01005319             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6468:18854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005319
VERSION     KCXD01005319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6468:18854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63801.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       439..447
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          109 a          114 c          145 g          123 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gcgattttaa
      121 gaggtgtcca gtgtgaggtg ctactggtgg agtctggagg aggcttggtt cagccggagg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat ggcttccact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg aatgatgaaa
      301 ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga gacaattcca
      361 tgaacatgct ttttcttcaa atgaacaacc tgaacttgga cgacacggcc gtctattact
      421 gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005320             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5959:21176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005320
VERSION     KCXD01005320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5959:21176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63802.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       418..429
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          109 a          139 c          137 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aagaaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga gatctgagga cacggccgtc tattactgtg cgattggccc tagtggcagc
      421 tggaacgact ggtccttcga catttgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005321             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19735:14896
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005321
VERSION     KCXD01005321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19735:14896"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..433
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63803.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       444..456
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          112 a          122 c          154 g          120 t
ORIGIN      
        1 acatggggcc aggagaggag cccagccctg ggattcccag gtgttttcac ttgtgatcag
       61 cactgaacac agaagactca tcatggagat tggcctgagc tgggttttcc ttgttgcaat
      121 tttaaaaggt gtccagggtg aggtgcagct ggtggaatct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accctcagta actactggat
      241 gtactgggtt cgccaggcac cagggaaggg gctggagtgg atctcagcta ttaatagtgt
      301 tggtgataac acatactatg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagttccgg gcctagtggt atttaccggt tcgcttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005322             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13918:10937
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005322
VERSION     KCXD01005322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13918:10937"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63804.1"
                     /translation="CARDESAWNYPFDYW"
     D_segment       406..415
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          142 c          131 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ccggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc actcactggt ggagctggat ccgccagccc cccgggaagg gactggagtg
      241 gattggacgt atctctggta ctagtgggag gactgactac aacccctccc tcgagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ttgaagttga attctgtgac
      361 cgccgcggac acggccctat attactgtgc gagagatgag tccgcctgga actatccctt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005323             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4574:20231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005323
VERSION     KCXD01005323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4574:20231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63805.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          115 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcattc
      241 actgggtccg ccagactcca gggaaggggc tggagtgggt ggccgttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaccat ggtgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtatttt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005324             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10535:10603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005324
VERSION     KCXD01005324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10535:10603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63806.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       448..464
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          120 c          153 g          127 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccctc agtaactact
      241 ggatgtactg ggttcgccag gcaccaggga aggggcttga gtggatctca gctattaata
      301 gtgttggtga tagcacatac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agagcgccaa gaacacacta tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcgagagta ccgggcctag tggtatttac tgcttcactt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005325             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21685:7589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005325
VERSION     KCXD01005325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21685:7589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63807.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       431..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          113 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggaacc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt attgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtagc tatggcttgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtctgatg
      301 aaagtaggaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag ggatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005326             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:25364:10918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005326
VERSION     KCXD01005326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:25364:10918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63808.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          124 a          141 c          134 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg agaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag gacagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagt ctgagatctg aggacacggc cgtatattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01005327             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21255:10517
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005327
VERSION     KCXD01005327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21255:10517"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63809.1"
                     /translation="CARVSGYSSLYFYTFESW"
     D_segment       407..415
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..476
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           94 a          137 c          135 g          112 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc agcagtagta actggtggag ctggatccgc cagtccccag tgaaggggct
      241 ggaatggatt gggggtctct atggtagtgg tgggaacacc gaatacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccac ttctccctga acctgaattc
      361 tgtgaccgcc gcggacaccg ccgtgtatta ctgtgcgaga gtttccggat atagcagcct
      421 gtatttttat actttcgaat cgtggggccg aggggtcgtc gtcatcgtct cttcagcc
//
LOCUS       KCXD01005328             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:17907:14978
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005328
VERSION     KCXD01005328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:17907:14978"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..322
     V_segment       10..261
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <253..>291
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63810.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       272..281
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..322
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>324
                     /gene="IGHG"
BASE COUNT           76 a           82 c           94 g           72 t
ORIGIN      
        1 acatgggggg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt
       61 tttggcatcc actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata
      121 tcgtctgatg aaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc
      181 agagacaatt ccaagaacat gctatatctt caaatgaaca acctgaagtt ggaggacacg
      241 gccgtctatt actgtgcgag agacgcatat ggcagcggct gtgactactg gggccaggga
      301 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005329             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12438:17113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005329
VERSION     KCXD01005329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12438:17113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63811.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          113 c          156 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactacgca gactctgtga aggcccgatt caccgtctcc agagacaaat
      361 ccaagaacat gttatatctt caaatggaca acctgaaatt ggaagacacg gccgtctatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005330             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17767:8997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005330
VERSION     KCXD01005330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17767:8997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63812.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       296..302
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           84 a           78 c          108 g           80 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
       61 aagcctctgg attcaccttc aggagttatg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttatatcgt atgatgtaag taagaaatat tacgcagacg
      181 ctgtgaagga ccgattcacc atctccagag acaattccaa gaacacgcta tatcttcaaa
      241 tgaacaacct gaaattggag gacacggccg tgtattactg tgggagagat gataatgggg
      301 tgcttatcga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005331             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:9454:11216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005331
VERSION     KCXD01005331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:9454:11216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63813.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       407..413
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           96 a          136 c          129 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tctcctgcga tgtctctggt
      181 gactccatca gtagtagctt ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatctatgg tagtactgga agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcaaag aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg gagatgacag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005332             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:19363:6871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005332
VERSION     KCXD01005332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:19363:6871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63814.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       439..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          124 c          154 g          114 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccattgtg aggtgcagct ggtggaatct gggggcggct tggcaaagcc
      181 tggggggtcc ctaagactct cctgtgcagc atccggattc accttcagtg accactgcat
      241 gcactgggtc cgccaggctt cagggaaggg gctggagtgg gtctcaggta ttacttatgc
      301 tggtgttacc acatggtacg cagactccgt gaggggcaga ttcaccatat ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga cctgaggaca cggctgtcta
      421 ttactgtgtg ggaggaaggc ggcacgtgga ccttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005333             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:26415:15098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005333
VERSION     KCXD01005333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:26415:15098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63815.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          114 c          146 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cggtgtgagg tgcaactggt ggagtctgga ggaggcttgg tgcaacctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact ttggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt cgtctgatgg
      301 aaataacaaa tactacgcaa cctctgtgaa gagccgattc accatctcca gagacaattc
      361 caagagcata ctatttcttc aaatgaacaa cttgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gatgatattg ggaccggttt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005334             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21129:9620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005334
VERSION     KCXD01005334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21129:9620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63816.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       403..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           95 a          137 c          132 g          117 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc cttgtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcacgagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgt
      181 ctccatcaac attaactact ggagctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt atctatggtg gtgatggcta taccacctcc aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga agtctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatccg cgttacgagg atgatcacgg
      421 ttactattct gtggaaattg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01005335             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16606:20876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005335
VERSION     KCXD01005335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16606:20876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63817.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       437..445
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          145 c          143 g           98 t
ORIGIN      
        1 acatgggaca taacaaccac gtccctcctc taaagaagcc cctgggaaca cagctcatca
       61 ccatggactt gacctggagg ctcctctttg tggtggcagc ggctacaggt gcccagtccc
      121 aggtccagct ggtgcagtcc ggggctgagg tgaagaagcc tggggcctca gtgaagctct
      181 cctgcaaggc ttctggatac accttcagca tccatggcat cagttgggtg cgacaggccc
      241 ctggacaagg gcttgagtgg atgggaggga tcatccctct tgttgattta acacactacg
      301 cacagaagtt ccagggcaga gtcacgatta ccgcggacac gcccacaagc acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggcctttta ttactgtgcg agagggacaa
      421 cccacctcga gatggcaact ggaatcggag actactttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005336             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12994:16571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005336
VERSION     KCXD01005336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12994:16571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..511
     V_segment       140..431
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63818.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       446..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          124 c          146 g          129 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcagtg actatgccct
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg attggctata ttagaagcca
      301 atataacaat ttcgcgacag aatacgcccc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacgc tatttctgca aatgagtagc ctgaaaccga ggacacggcc
      421 gtgtattact gcaccaccca ttttggtggt aattattact tggactactt tgtctactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005337             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22967:8453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005337
VERSION     KCXD01005337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22967:8453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63819.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       421..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          101 a          138 c          137 g          113 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa tgctctctga gagtcatgga cctcctgtgc
       61 aagaacatga agcacctgtg gttcttcctt ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc agctgcagga gtcgggccca ggactggtga agtcttcgga gaccctgtcc
      181 ctcacctgcg gtgtctctgg tgactccatc agcaatagct actggaactg gatccgccag
      241 cccccaggga agggactgga gtggattggg tatatctctg gtgcttatgg gagcaccagc
      301 tacaacccct ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccagttt
      361 tccctgaggc tgagttctgt gaccgccgcg gacaccgccg tgtattattg tgtgagatat
      421 gaggatgaat ccattaacta ccactttgac tgctggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01005338             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:4310:18134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005338
VERSION     KCXD01005338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:4310:18134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..443
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63820.1"
                     /translation="CAKFFGVIW"
     D_segment       403..408
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT           88 a          133 c          129 g           95 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc gcctgcactg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgt atctatggta gtagagggaa caccaactac aacccctccc tcacgagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttgtcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gaagtttttt ggagtgatct ggggccaggg
      421 agtcccggtc accgtctcct cagcc
//
LOCUS       KCXD01005339             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18657:13466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005339
VERSION     KCXD01005339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18657:13466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63821.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          155 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaac taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tctattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01005340             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16591:7668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005340
VERSION     KCXD01005340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16591:7668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..498
     V_segment       120..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63822.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       417..436
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          140 c          144 g          108 t
ORIGIN      
        1 acatgggaca taacaaccac gtccctcctc taaagaagcc cctgggaaca cagctcatca
       61 ccatggactt gacctggagg ctcctctttg tggtggcagc agctacaggt gcccagtctc
      121 aggtccagct ggtgcagtcc ggggctgaga tggagaagcc tggggcctca gtgaagctct
      181 cctgtaaggc ttctggatac accttcagca tctatgtcat cagttgggtg cgacaggccc
      241 ctggacaagg gcttgagtgg atgggaggca tcttccctct tgttggtaca acaaactacg
      301 cacagaagtt ccagggcaga gtcacgatta ccgcggacac gtccacaagc acagcctaca
      361 tggacctgag cagcctggga tctggggaca cggccgtgta ttattgtgcg agaggttact
      421 gtactggtag tggttgtaac cttacattca accggctcga tgtctggggc ccgggagtcc
      481 cggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005341             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:7850:19014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005341
VERSION     KCXD01005341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:7850:19014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63823.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          118 a          118 c          143 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggagactt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgc ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggaat taacattggc
      301 ggtgacccat actacccaga ctctgttaag ggtcgattca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca gatgaacaat ctgagagctg aggacactgc tgtgtattat
      421 tgtgtgaggg gaatggataa ctaccactac agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005342             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18122:17018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005342
VERSION     KCXD01005342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18122:17018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63824.1"
                     /translation="CARDVYGTGLDYW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          110 c          157 g          122 t
ORIGIN      
        1 acatggggag gtctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg tagcctctgg attcagtttc agtggctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatctcgt
      301 atgatgaaac taagaaatat tacgcagact ttgtgaagga ccgattcacc gtctccagag
      361 acaatgccaa gaacatgcta tatattcaaa tgaacaacct gaaattggaa gacacggccg
      421 tgtattactg tgcgagagat gtctatggca cgggacttga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005343             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13736:11906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005343
VERSION     KCXD01005343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13736:11906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..477
     V_segment       111..396
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63825.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       412..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          111 c          134 g          124 t
ORIGIN      
        1 acatggggag gtgttttcat tcagagatca ggactgaaca cacaggactc accatggagt
       61 ttatgctgag ctgggttttc cttgtttcta tattaaaagg tgtccagtgt gtggagcatc
      121 tggtggagtc tgggggaggc ttggtacagc ctggggcgtc cctgagactc tcctgtgcag
      181 cctctgaatt caccttcagt ggctatgaca tgcactgggt tcgccaggct ccagggaagg
      241 gtctagaatg ggtatcaggt attaacattg gcggtgaccc atactaccca gactctgtga
      301 agggtcgatt caccatctcc agagacaacg ccaagaactc cttgtatctt caaatgaaca
      361 acctgagacc tgaggacact gctgtgtatt attgtgtgag ggggatggat aactaccact
      421 tcagtaatac ggactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005344             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14552:7020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005344
VERSION     KCXD01005344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14552:7020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63826.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          115 c          155 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tactttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttcg gaacctatgg
      241 cattcactgg gtccgccagg ctccagggaa gggcctggag tgggtgacgg ttatatcgaa
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcagca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacgtg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cgtttggtag cgggcttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005345             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16311:5084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005345
VERSION     KCXD01005345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16311:5084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..448
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63827.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       376..393
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..448
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           94 a          131 c          128 g           97 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccaggt gcaactgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacctg cgctgtctct ggtggctccc tcagcggtta ctactggagc
      181 tggatccgcc agcccccagg gaaggggctg gagtggattg gatatatcag tgctagtagt
      241 ggaaacaccg actacaaccc ctccctcaag agtcgagtca ccatttcaac agacacgccc
      301 aagaaccagt tctccctgat gctgagctct gtgaccgccg cggacacggc cgtgtattat
      361 tgtgcgagag agaaatacta tagtggtagt tataaacaca actggttcga tgtctggggc
      421 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005346             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10465:8728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005346
VERSION     KCXD01005346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10465:8728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..441
     V_segment       87..380
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63828.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       386..393
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..441
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           96 a          102 c          135 g          110 t
ORIGIN      
        1 acatggggac agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg
       61 ttgctatttt aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg
      121 ttcagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtcact
      181 ttggcttaca ctgggtccgc caggctccag ggaaggggct ggagtgggtg acagttatct
      241 cgcatgatgg caataacata tactacgcag actctatgaa ggaccgattc accatctcca
      301 gagacaattc gaagaacatg gtatatcttg aaatggacaa cctgcaattg gaggacacgg
      361 ccgtgtattt ctgtgtgaga gatgcctacg gtaccgggtt ggattcctgg ggccaagggg
      421 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005347             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22507:7356
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005347
VERSION     KCXD01005347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22507:7356"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63829.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          141 c          132 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaac gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005348             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13414:19125
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005348
VERSION     KCXD01005348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13414:19125"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..420
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63830.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT           98 a          146 c          139 g          109 t
ORIGIN      
        1 acatggggag ggtccagctc atatgggaaa tgttctctga gagtcacgga catcctgtgc
       61 aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc agctgcaggg gtcgggccca gggctggtga agccttcgga gaccctgtcc
      181 ctcacctgcg ctgtttctgg tgactccatc aacagtggct actactggag ttggatccgc
      241 caacccccag ggagggggct ggagtggatt gggtctatcg gtggtagtag tggcagcacc
      301 tactacaacc cctccctcaa gagtcgagtc accctttcaa aagacacgtc caggaaccag
      361 ttctccctga aactgagctc tgtgaccgcc gcagacacgg ccgtttatta ctgtgcgaga
      421 aaacttccag gtctccaact aaccggtttc gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01005349             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17650:12399
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005349
VERSION     KCXD01005349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17650:12399"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..439
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63831.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       442..448
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          115 a          122 c          159 g          121 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattcccagg cgtctccact tggtgatcag
       61 cactgaacac aagagactca ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgtagg ctctggattc accttcagtg actatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg gttggctata ttagaagcaa
      301 atcttacaat tacgcggcag aatacgccgc atcggtgaaa ggcaggttca ccgtctccag
      361 agatgattca aagaacacgc tacatctgca aatgagcagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgtgctagag gggatatacc ggctatagag gcctactacg gtttggattc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005350             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18665:16165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005350
VERSION     KCXD01005350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18665:16165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63832.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          142 c          141 g           99 t
ORIGIN      
        1 acatggggtt cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctgggacct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgta tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005351             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13290:7045
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005351
VERSION     KCXD01005351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13290:7045"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..502
     V_segment       139..431
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63833.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       438..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          119 c          157 g          118 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc actcccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcagttg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtctc tgagactctc ctgtgtagcc tctggattca gcttcagaag ttacgaaatg
      241 agttgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagtcacact
      301 ggtgaaacca tataccacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agtctgagag ccgaggacac ggccgtgtat
      421 tactgtacta gaaaccggaa tactgtaatg attgggtggt tcgatgtctg gggcccggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005352             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20347:12734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005352
VERSION     KCXD01005352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20347:12734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..488
     V_segment       113..402
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <398..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63834.1"
                     /translation="CVRERGEDGGAGIPHYFDYW"
     D_segment       427..434
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          141 c          140 g           99 t
ORIGIN      
        1 acatgggaac cacgtccctc ctctaaagaa gcccctggga acacagctca tcaccatgga
       61 cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt cccaggtcca
      121 gctggtgcag tccggggctg aggtgaagac gcctggggcc tcagtgaaac tctcctgcaa
      181 gacttctgga tacagcttca gcatctatgc catccattgg gtgcgtcagg cccctggaca
      241 aggccttgag tggatgggac ggatcgtccc tcttgttggt atgacaaact acgcacagaa
      301 gttccaggac agagtcacac ttaccgcgga cacgtccaca aggacagcct acatggaact
      361 gagcagcctg agatctgacg acacggcctt ctattattgt gtacgagaga ggggcgaaga
      421 tgggggagct ggaatccccc actactttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01005353             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20706:5202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005353
VERSION     KCXD01005353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20706:5202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63835.1"
                     /translation="CAKSRSSSLHWDFDFW"
     D_segment       438..444
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..500
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          108 a          131 c          150 g          113 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggaatc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtcg gggggcggct tggcaaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcagta cctatgctat
      241 gcactgggtc cgccaggctc caggtaaggg gctggagtgg gtctcagcta tgagtgttgc
      301 tggaagcaca tactacgcag gctccgtgaa gggccgattc accgtctcca gagacaactc
      361 aaagaacatg ttctccctgc aaatggacaa cctgacacct gaggacacgg ccgtgtatta
      421 ctgtgcgaaa agtcggagta gtagccttca ctgggacttc gatttctggg gccctggcac
      481 cccaatcaca atctcctcag cc
//
LOCUS       KCXD01005354             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20444:14579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005354
VERSION     KCXD01005354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20444:14579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63836.1"
                     /translation="CARWSAANFDYW"
     D_segment       403..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           89 a          137 c          133 g           99 t
ORIGIN      
        1 acatggggag ttctctgaga gtcacggacc tcctgggcaa gaacatgaag catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcaa cagtggttat ggctggagct gggtccgcca gcccccaggg aagggtccgg
      241 agtggattgg gtgtctctat gatagtagtg gcaacacgta ctacaacccc tccctcaaga
      301 gtcgcgtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaac ctgaggtcta
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagatg gtcggcagcc aactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005355             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:10771:15429
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005355
VERSION     KCXD01005355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:10771:15429"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63837.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          121 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcctgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaaggg ccgattcacc atctccagag
      361 acaattccaa aaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005356             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22298:10681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005356
VERSION     KCXD01005356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22298:10681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63838.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       438..445
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          107 a          113 c          154 g          121 t
ORIGIN      
        1 acatgggctg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagttg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtca ctttggctta
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgcatgat
      301 ggaaataaga tatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tcgaagaaca tggtatatct tgaaatggac aacctgcaat tggaggacac ggccgtgtat
      421 ttctgtgtga gagatgccta cggtaccggg ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005357             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13824:8144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005357
VERSION     KCXD01005357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13824:8144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63839.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          118 a          145 c          133 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgac cctgcatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatctga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005358             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5323:13734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005358
VERSION     KCXD01005358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5323:13734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63840.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          142 c          129 g           91 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaagct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatggtaaag tagactacac
      301 acagaagttc cgagacagag tcaccatcac cgcggacatg tcgacagaga cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgacttct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005359             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16808:18293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005359
VERSION     KCXD01005359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16808:18293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63841.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       435..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          111 c          158 g          115 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ttttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttac atcgtctgat
      301 gaaaataaga aatactacga agactctctg aaggcccgat tcaccgtctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatggac aacctgaaat tggaagacac ggccgtgtat
      421 tactgcgcga gagatgtctg ggggagggga tttgactatt ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005360             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18195:11854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005360
VERSION     KCXD01005360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18195:11854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63842.1"
                     /translation="CATGGLRTPHYW"
     D_segment       401..408
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           83 a          144 c          133 g           96 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccatca gcggttactg gtggtcctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatcggtgg tactagtggg agcacctact acaacccctc cctcaagagt
      301 cgagtcacct tttcaacaga cacgtccaag aaccagttct ccctgaccct gacctctgtg
      361 agcgccgcgg acacggccgt atattactgt gcgaccggag gactacggac cccccactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005361             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18950:8009
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005361
VERSION     KCXD01005361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18950:8009"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..489
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63843.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       433..441
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          115 a          108 c          157 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagttatt atggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatgt cgaatgatgg
      301 aagtaagaaa tactacggag actctgtgaa ggaccgattc agcatcgcca gagacaattc
      361 caagaacagg ctatatcttc aaatgaacaa cctgaaaatg gaggacacgg cagtgtatta
      421 ctgtgcgaga gatgatagtg gggtgatcat cgactactgg ggccagggag tcctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01005362             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:19814:12140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005362
VERSION     KCXD01005362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:19814:12140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63844.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           88 a          142 c          132 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaatagaca cgtccaggaa ccagttctcc ctgcagctga attatgtaac
      361 cgccgcggac acggccgtgt attactgtgc cagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccggggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005363             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15983:19126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005363
VERSION     KCXD01005363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15983:19126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63845.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcgcccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttttg tcgtctgatg
      301 gaggttacaa ataccacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005364             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14353:11135
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005364
VERSION     KCXD01005364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14353:11135"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63846.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          139 c          138 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattggcttt ttcggtggta gtggtgggag cacctactac aagtcctccc tccagagtcg
      301 agtcaccatt tcaaccgaca cgtccaagaa ccagttctcc ctgatactga cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gagggggaat atagcagcga ctggcattga
      421 ctactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005365             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24517:7253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005365
VERSION     KCXD01005365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24517:7253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..496
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63847.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       428..438
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          118 a          145 c          139 g           96 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc aacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccacctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacac cgtcaccgaa ttatccatgc actgggtgcg acaggcccct
      241 ggacaagggc ttgagtggat gggacttgtt gatcctgtaa atggtgaact aatacacgca
      301 gacaacttcc agggcagagt caccatgacc gaagacacgt ctacagacac agcctacatg
      361 gagttgagca gcctgacatc tgaggacacg gccatctact actgtgcgac agggaggatc
      421 ggtaccagtg gctggtccaa cctcttcaat ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cttcagcc
//
LOCUS       KCXD01005366             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13357:14819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005366
VERSION     KCXD01005366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13357:14819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    72..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        72..426
     V_segment       72..365
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63848.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       372..377
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       380..426
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT           91 a           95 c          128 g          114 t
ORIGIN      
        1 acatgggact caccatgaag tttgggctga actgggtttt ccttgttact tttttaagag
       61 gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag cctggggggt
      121 ccctaagact ctcctgtgca gcctctggat tcaccttcag tacttttggc atccactggg
      181 tccgccaggc tccagggaag ggtctggagt gggtggcagt tatatcgaat gatggaagta
      241 gaaaatacta cccagactct gtgaaggacc gattcaccat ctccagagac aattccgagg
      301 ccaatgtata tcttcaaatg aataacctga aattggagga cacggccgtg tattactgtg
      361 tgagagatgc gtatggttcc ggtttggatt cctggggcca aggggtcgtc gtcgccgtct
      421 cctcagcc
//
LOCUS       KCXD01005367             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:11770:11146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005367
VERSION     KCXD01005367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:11770:11146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63849.1"
                     /translation="CVRDVYGTGFDYW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          116 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacggagga ctcaccatga agtttgggct gagctgggtt ctccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 ctgatgaaaa taacatatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgggcaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtctacggta ccggatttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005368             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20224:5511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005368
VERSION     KCXD01005368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20224:5511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..400
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63850.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       416..423
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          100 a          140 c          131 g          104 t
ORIGIN      
        1 acatggggga tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtga agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 aggctctatc agcggtgttt atgactggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtatgtcc atggtaatac tgggaacacc gactacaacc cgtccctcaa
      301 gaatcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga cgctgaggtc
      361 tgtgaccgcc gcggacacgg ccgtatatta ctgtgcgaga cgcccagaaa acagttacta
      421 cttctactac tttgactact ggggccacgg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005369             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14428:19204
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005369
VERSION     KCXD01005369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14428:19204"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63851.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       424..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          146 c          142 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga ggtgttgatc ctggacatag tgaaatgata
      301 cacgcagaca acttccaggg cagagtcgcc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgacccac
      421 ggagggtata gaggcatctg gaactcccta tactacggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005370             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:28494:10589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005370
VERSION     KCXD01005370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:28494:10589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63852.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          117 c          154 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactttg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      301 atgatgaaac taagaaatat tacgcagact ctgttaggga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct ggatttggag gacacggccg
      421 tgtattactg tgcgagggac gcatttggca gcggctgtga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005371             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15945:3004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005371
VERSION     KCXD01005371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15945:3004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63853.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       424..431
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          143 c          133 g           98 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgaattat cgtttcactg ggtgcgccag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcgtatgg tgaaatgata
      301 cacacagaga acttccaggg cagaatcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc taagcagcct gagatctgag gacacggccg tgtattactg tgcgatatca
      421 tccagcggca gttggctatt ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005372             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13308:9728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005372
VERSION     KCXD01005372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13308:9728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..339
     V_segment       6..277
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <270..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63854.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       288..293
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..339
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           78 a           78 c          103 g           82 t
ORIGIN      
        1 acatgggggg aggcttggtt cagcctgggg ggtccctgag actctcctgt acagcctctg
       61 gattcatgtt cagtaactat ggcatccact gggtccgcca ggctccaggg aaggggctgg
      121 agtgggtgtc agttatatcg tatgatgtaa ctgtgaaata ctacgcagac tctgtgaagg
      181 accgattcac catctccaga gacaattcca agaacacgct atatcttcaa atgaacaacc
      241 tgaaattgga ggacacggcc gtgtattatt gtgtgaggga tgtcagggga acggggtttg
      301 acttctgggg ccagggagtc ctggtcaccg tctcgtcagc c
//
LOCUS       KCXD01005373             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8446:9278
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005373
VERSION     KCXD01005373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8446:9278"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..485
     V_segment       134..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63855.1"
                     /translation="CANALTGGLDYW"
     D_segment       432..440
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          105 a          120 c          155 g          107 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcaccactga
       61 acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggtact ggatgaactg
      241 ggtccgccag gctccaggaa aggggctgga gtgggtctca gctattgcaa gtggtggaga
      301 aaacacatac tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaactcaaa
      361 gagcacagtc tccctgcaaa tgaacagtct tagaacggag gacacggccg tgtattactg
      421 tgcgaatgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005374             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19057:9484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005374
VERSION     KCXD01005374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19057:9484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63856.1"
                     /translation="CVTSSSGTWLYWYFDVW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          142 c          133 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa gatttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtatatggt gaaattataa
      301 attcagagag gttccagggc agagtcaccc tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgaag acacggccgt gtattattgt gtgacctcat
      421 ccagcggcac ctggctatac tggtacttcg atgtctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01005375             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20039:17181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005375
VERSION     KCXD01005375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20039:17181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..494
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63857.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          118 a          115 c          150 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg ccgcctctgg attcaccttc gatacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatgaaac taaaaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaaattggag gacacggcca
      421 tgtattactg tgtgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctccacagcc
//
LOCUS       KCXD01005376             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:21843:17955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005376
VERSION     KCXD01005376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:21843:17955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..494
     V_segment       119..418
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63858.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       421..427
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          118 c          148 g          118 t
ORIGIN      
        1 acatgggggg attcccaggc gtctccactt ggtgatcagc actgaacaca agagactcac
       61 catggagttt gtactgagct gggttttcct tgttgctatt ttaaaagggg tccagtgtga
      121 ggtgcagctg gtggagtctg ggggaggctt ggtccagcct ggcgggtccc tgagactctc
      181 ctgtgcaggc tctggattca ccttcagtga ctatgccatg agctgggtcc gccaggcttc
      241 tgggaaagga ctggagtggg ttggctatat tagaagcaaa tcttacaatt acgcgacaga
      301 atacgccgca tcggtgaaag gcaggttcac catctccaga gatgattcaa agaacaccct
      361 acatctgcaa atgagcagcc tgaaaatcga ggacacggcc gtgtattact gtgctagagg
      421 ggatataccg gctatagagg cctactacgg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005377             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13902:10137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005377
VERSION     KCXD01005377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13902:10137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..454
     V_segment       76..367
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63859.1"
                     /translation="CVRDIPYYNFWSGYDSGLDAW"
     D_segment       378..402
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       408..454
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           94 a          104 c          141 g          117 t
ORIGIN      
        1 acatggggag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
       61 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      121 gggtccctga gactctcctg cgcagcctcc ggattcatct tcagtgacca ctacatggac
      181 tgggtccgcc aggctccagg gaaggggctg gaatgggtct cacgtgttac taatgatggt
      241 ggtagcacat ggtacgcaga ctccgtgaag gacagattca ccatctccag agagaacgcc
      301 gagaacaccc tttatcttca aatgaaaagc ctgagagctg aggacacggc tgtctatttt
      361 tgtgtgagag atattccgta ttacaatttt tggagtggtt atgactccgg tttggatgcc
      421 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01005378             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18149:20644
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005378
VERSION     KCXD01005378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18149:20644"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63860.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       444..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          110 c          157 g          117 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agcttcagta tctttggcat
      241 gcattgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tgtcgaatga
      301 tggaagtaag aaatactaca cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaaa atgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttattgcgcg agagacgatt ttggcagcgg cttagggtac tggggccagg gagccctggt
      481 gaccgtctcc tcagcc
//
LOCUS       KCXD01005379             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:25192:15349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005379
VERSION     KCXD01005379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:25192:15349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63861.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          114 c          147 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtcacaa atactacgcc aactctgtga agagccgatt cgccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005380             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10079:13389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005380
VERSION     KCXD01005380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10079:13389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63862.1"
                     /translation="CVRYDNWNNLYWFDVW"
     D_segment       399..409
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          138 c          126 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccgtcagc agtacctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggctat atctatggtg ctactgggag caccacctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga aatctgtgac
      361 cgccgcggac accgcctttt attattgtgt gagatatgat aactggaaca acttgtactg
      421 gttcgatgtc tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005381             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13178:20533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005381
VERSION     KCXD01005381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13178:20533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..455
     V_segment       83..373
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63863.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       382..396
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           96 a          123 c          139 g           99 t
ORIGIN      
        1 acatgggaga gcacagcacc tcaccatgga ctggacctgg aggatcctcc tcttggtggc
       61 agcagctaca ggcgcccact ctgaggtcca gctggtgcag tctggggctg aggtgaagaa
      121 gcctggggcc tcagtgaagg tctcctgcaa ggtttccgga tccaccttca ccgaattatc
      181 catacactgg gtgcggcagg cccctggaaa agggcttgag tggatgggag gtgttgctcc
      241 tctatatggt gaaatgatgc tcgcagacaa cttccagggc agagtcacct tgaccgagga
      301 cacgtctaca gacacagcct acatggagct gagcagcctg agatctgacg acacggccgt
      361 gtattactgt gcgcgtgggc ctattacaat ttttggcgta cttattacgg ggcttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005382             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14867:3467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005382
VERSION     KCXD01005382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14867:3467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63864.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          116 a          143 c          128 g           91 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct ctttgtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggga aagtagacta
      301 cacacagaag ttccaagaca gagtcaccat caccgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccact tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005383             297 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:28265:15143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005383
VERSION     KCXD01005383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 297)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:28265:15143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..295
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..295
     V_segment       7..225
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>264
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63865.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       229..236
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..295
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        296..>297
                     /gene="IGHG"
BASE COUNT           68 a           83 c           79 g           67 t
ORIGIN      
        1 acatggggtg actccatcag caatagctac tggaactgga tccgccagcc cccagggaag
       61 ggactggagt ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc
      121 ctcaagagtc gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg
      181 agttctgtga ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc
      241 attaactacc actttgactg ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005384             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:26333:13241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005384
VERSION     KCXD01005384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:26333:13241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63866.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          141 c          126 g          100 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatcc ctgcactggg ttcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag ttttaatcct atatatggtg aaattttaca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagctta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01005385             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19459:14976
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005385
VERSION     KCXD01005385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19459:14976"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..336
     V_segment       8..251
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <243..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63867.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       260..267
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..336
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           76 a           81 c          108 g           73 t
ORIGIN      
        1 acatgggagt gaaggtctcc tgcaaggttt ccggagacac cttcaccgaa ttatccatgc
       61 actgggtgcg acaggcccct ggaaaagggc ttgagtggat gggaggtgtt gaccctggaa
      121 atggtgaaat aatacacgca gatagtttcc agggcagagt caccatgacc gaggacacgt
      181 ctacagacac agcctacatg gagctgagcg gcctgagatc tgaggacacg gccgtgtatt
      241 actgtgcgag aggggggttc ggtagcagtg tctggtccaa tctcgtttat ggtttggatt
      301 cctggggcca aggggtcgcc gtcaccgtct cctcagcc
//
LOCUS       KCXD01005386             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:26162:14757
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005386
VERSION     KCXD01005386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:26162:14757"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63868.1"
                     /translation="CVRDSSGSGFDYW"
     D_segment       439..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          111 c          149 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ttctggcata
      241 cactgggtcc gcctggctcc agggaagggg ctggagtggg tggcagttat atcgtacgat
      301 gaaaataaga aatactatac agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaaaaaca tggtatatct tcacatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagattcaag cggttcggga tttgactatt ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005387             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18597:5679
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005387
VERSION     KCXD01005387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18597:5679"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63869.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          118 a          143 c          139 g           92 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaactat ccatgcactg ggtgcgacag
      241 gcccctggaa aaggacttca gtggatggga agtgttgatc ctgcatttgg tgaaatgatc
      301 aacgcagaga agttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaggagcct gagatctgag gacacggccg tgtattactg tgcgagtggc
      421 cctagcggca gctggaacga ctggtatttc gatatctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01005388             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:11486:12144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005388
VERSION     KCXD01005388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:11486:12144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..474
     V_segment       111..404
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63870.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       413..428
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           93 a          140 c          138 g          105 t
ORIGIN      
        1 acatggggga tgggagatgc tctctgagag tcatggacct cctgtgcaag aacatgaagc
       61 acctgtggtt cttccttctc ctggtggctg ctcccagatg ggtcctgtcc cagctgcatc
      121 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg
      181 tctctggtgg ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg
      241 ggctggagtg gattgggtct atctatggtg gtactgggag cgccggctac aacccctccc
      301 tcaagagtcg agtcaccgtt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga
      361 cgtctgcgac cgccgcggac accgccgtgt attactgtgc gagatatgag gatgaataca
      421 gtgactacca ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005389             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11042:11390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005389
VERSION     KCXD01005389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11042:11390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63871.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       413..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          109 a          142 c          137 g           91 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtctt tctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccctca ccgaagtgtc cactcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtccacaga cacagcctac atggaattga
      361 gcagcctaag atctgaggac acggccgtgt attactgtgc gattggacct accggcaggt
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01005390             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11946:10255
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005390
VERSION     KCXD01005390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11946:10255"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63872.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       416..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          139 c          128 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcttggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gcctggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatctctgg tgcttatggg agtaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaactga cacgtccaag aaccagtttt ccctgaggct ggcttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggacgaatc cataaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005391             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16822:22101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005391
VERSION     KCXD01005391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16822:22101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..461
     V_segment       107..403
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63873.1"
                     /translation="CARWSAANFDYW"
     D_segment       408..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           93 a          137 c          134 g           99 t
ORIGIN      
        1 acatggggga aaaagttctc tgagagtcac ggacctcctg ggcaagaaca tgaagcatct
       61 gtggttcttc ctcctcctgg tggcagctcc cagatgggtc ctgtcccagg tgcaactgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgctgtctc
      181 tggtggctcc atcaacagtg gttatggctg gagctgggtc cgccagcccc cagggaaggg
      241 tccggagtgg attgggtgtc tctatgatag tagtggcaac acgtactaca acccctccct
      301 caagagtcgc gtcaccattt caaaagacac gtccaagaac cagttctccc tgaacctgag
      361 gtctatgacc gccgcggaca cggccgtgta ttactgtgcg agatggtcgg cagccaactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005392             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19895:10600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005392
VERSION     KCXD01005392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19895:10600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63874.1"
                     /translation="CARVGEGSGGAEDFDFW"
     D_segment       441..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          112 c          160 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg attcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcacttata tcgtatgatg
      301 gaactaagaa atactacgca gactctgtga aggaccggtt caccatttcc agagacaatt
      361 ccgacaacat ggtatatctt cagatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag agttggggag ggtagtggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005393             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:12103:10240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005393
VERSION     KCXD01005393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:12103:10240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63875.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          118 c          152 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcggc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttttggca
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt atatcgtctg
      301 atgaaagtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa gttggaggac acggccgtct
      421 attactgtgc gagagacgca tatggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005394             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:27270:12521
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005394
VERSION     KCXD01005394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:27270:12521"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..453
     V_segment       99..395
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63876.1"
                     /translation="CARWSAANFDYW"
     D_segment       400..406
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           90 a          133 c          136 g           96 t
ORIGIN      
        1 acatggggtc tctgagagtc acggacctcc tgggcaagaa catgaggcat ctgtggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcaactg caggagtcgg
      121 gcccaggact ggtgaagcct tcggagaccc tgtccctcac ctgcgctgtc tctgggggct
      181 ccatcagcag tggttatggc tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggatggggtg tatctatgat agtagtggaa acacctacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaaaagac acgtccaaga accagttctc cctgaagctg aggtctatga
      361 ccgccgcgga cacggccgtg tattactgtg cgagatggtc ggcagccaac tttgactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005395             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7608:3119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005395
VERSION     KCXD01005395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7608:3119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63877.1"
                     /translation="CAIGPTGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          143 c          135 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg acacaccttc accgaattgt ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgaag
      301 ttccaggcca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgtg tattactgtg cgattggccc taccggcagg
      421 tggaatgact ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005396             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:4735:12424
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005396
VERSION     KCXD01005396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:4735:12424"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63878.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          101 a          123 c          161 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagt ttcagtcact acttcatgag
      241 ctgggtccgc caggctccag ggaaagggct ggggtggatc tcagggatta acagtggtgg
      301 ggatactaca taccacgcag actccgtgaa gggcagattc accatgtcca gagagaacgc
      361 caggaacaca ctgtctcttc aaatggacgg cctgagagct gaggactcgg ctgtctatta
      421 ctgtgcgaga gatcgacgtg tacagtcgtt atcttggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005397             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16035:11691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005397
VERSION     KCXD01005397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16035:11691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..486
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63879.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       423..430
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..486
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>490
                     /gene="IGHG"
BASE COUNT          109 a          139 c          144 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgcagt gaagaggcct ggggcctcag ttaaggtctc
      181 ctgcaaggtt tccggatact ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctgtg tatggtgaag aaatacacgc
      301 agagaatttc caggacagag tcaccatgac cgaggacacg tccacagaca cagcctacat
      361 ggagctgagc agcctgagac gtgaggacac ggccgtgtat ttctgtgcgg cgggccttgg
      421 ggggtattta gttcttactg aatacctcga attctggggc cagggcgccc tggtcaccgt
      481 ctcctccgcc
//
LOCUS       KCXD01005398             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16210:4334
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005398
VERSION     KCXD01005398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16210:4334"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63880.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       434..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..498
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          128 c          149 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcgaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcaatacc tatgctatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ctcagctatt agtagtggtg
      301 gtagcacata ctacgtagac tccgtgaagg gccgattcac catctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgaacagtc tgagagatga ggacacggcc ttttattact
      421 gtgcgaaagg aggtagcagc tctttctact ggtacttcga tatccggggc cctggcaccc
      481 cagtcaccat ctcctcagcc
//
LOCUS       KCXD01005399             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21535:11406
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005399
VERSION     KCXD01005399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21535:11406"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..477
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63881.1"
                     /translation="CARHRPYYFSASYWANWFDVW"
     D_segment       403..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>481
                     /gene="IGHG"
BASE COUNT           92 a          142 c          135 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc gattactact gcagttggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggctat atctctggtg atagcgggag caccaacttc aagccgtccc tcaagagtcg
      301 agtcaccatt tcaaaagaca cgtccaagaa ccagttctcc ctgaccctga gttctgtgac
      361 cgccgcggac acggccgtct attactgtgc gagacatcga ccgtattact ttagtgctag
      421 ttactgggct aactggttcg atgtctgggg cccgggagtc ctggtcaccg tctcctctgc
      481 c
//
LOCUS       KCXD01005400             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:26368:9070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005400
VERSION     KCXD01005400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:26368:9070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63882.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          114 c          147 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatct
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa attctacgca gactctgtga aagaccgatt caccatctcc agagacaatt
      361 ccaagagcat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccctctatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005401             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18326:12470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005401
VERSION     KCXD01005401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18326:12470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63883.1"
                     /translation="CATGPSGTWNAWCLDFW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          142 c          136 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctgcag acacagccta catggaactg
      361 agtagtctga catttgagga cacggccgtg tattactgtg cgactggccc tagcggcacc
      421 tggaacgcct ggtgcctcga tttctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005402             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17567:14905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005402
VERSION     KCXD01005402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17567:14905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63884.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          119 c          152 g          119 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tatgtagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatagta tatcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga ctactggggc cggggcgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005403             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12985:8796
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005403
VERSION     KCXD01005403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12985:8796"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63885.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       429..439
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          144 c          141 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc caacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggacttgt tgatcctgta aatggtgaac taatacacgc
      301 agacaagttc cagggcagag tcaccatgac cgaagacacg tctacagaca cagcctacat
      361 ggagttgagc agcctgacat ctgaggacac ggccatctac tactgtgcga cagggaggat
      421 cggtaccagt ggctggtcca acctcttcaa tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcttcagcc
//
LOCUS       KCXD01005404             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8090:9339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005404
VERSION     KCXD01005404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8090:9339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63886.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          126 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggtgg tccctgagac tctcctgcgc agtctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccgccaga ctccagggaa gggactggag tggatctcag tgattaacag
      301 tggtggagat accacacact atgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccagg aacacactgt ctcttcaaat ggacggcctg agacctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005405             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:22579:7223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005405
VERSION     KCXD01005405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:22579:7223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..500
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63887.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       422..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          118 a          138 c          144 g          104 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggatt cacgttcagc accgatgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgattg gatgggaggg gtcatccctc ttatgggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgttt accgcggaca cgtcactaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attattgtgc gaaatccgtg
      421 aattacgagg aagataacgg ttactatata ccgacgcagt ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01005406             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18694:21308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005406
VERSION     KCXD01005406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18694:21308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63888.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       406..413
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..466
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           89 a          148 c          125 g          106 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtacaaga acatgcagtt tctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcagagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagtc gtaactggtg gagttgggtc cgccagcccc caggcaaggg actggagtgg
      241 attggacgta tctctggtag tcttggaagc accagttaca atccctccct cgagagtcga
      301 gtcaccattt caagagacac gtccaggaac cagttctccc tgaagctgac ctctgtgacc
      361 gccgcggaca cggccgtgta tttctgtgcg agacattcag accccgcaac tactagctgg
      421 tacttcgatc tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01005407             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:24204:11444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005407
VERSION     KCXD01005407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:24204:11444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63889.1"
                     /translation="CARDAGYGDTISLVDINMFPHFDYW"
     D_segment       425..437
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          102 a          133 c          139 g          121 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctggaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtgt tgtctctggt
      181 gcctccatca gtagttactg gtggagttgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg taatagtggt agtatttact acaacccttc cctcatcagt
      301 cgagtctcca tttcaaaaga cgcgtccaag aatcagttct ccctgaagct aaactctgtg
      361 accgccgcgg acacggccgt atattactgt gcgagagatg ccgggtatgg ggatacgatt
      421 tcactagtcg atattaatat gttcccccac tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005408             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11638:13694
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005408
VERSION     KCXD01005408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11638:13694"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63890.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          136 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctatccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005409             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13656:12926
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005409
VERSION     KCXD01005409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13656:12926"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63891.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       397..405
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          136 c          132 g          114 t
ORIGIN      
        1 acatgggggg gctctctgag agtcatggac ctcctgttca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaaa tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaactc ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggatcggtt atgtctatgg tgatagtggg aacaccgaat acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga ctcgtccaag aatcagtttt ccctgaagct gagttctgtg
      361 accgccgcgg acaccgccgt gtatcactgt gcgagataca gttacggttc caactacttc
      421 tttgggttct ttgactattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005410             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16895:6219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005410
VERSION     KCXD01005410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16895:6219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63892.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       401..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           90 a          136 c          131 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctacaa ttgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct gtctctggtg
      181 gctctatcaa catttactac tggaattgga tccgccaggc cccagggaag ggactggact
      241 ggattggaca tatctatggt agcggtggta gcaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtggac acgtccaaga accacttctc cctgaacctg aggtctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgagcggtcg gcggcagctg gactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005411             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10733:7932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005411
VERSION     KCXD01005411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10733:7932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..496
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <402..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63893.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       418..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          117 a          138 c          143 g          102 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgcgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gtaaggcttc tgggttcacc tttagcaccg aagccatcaa ttgggtgcga caggcccctg
      241 gacaaggact tgactggatg ggaggggtca tccctcttat gggtacaaca aactacgcac
      301 agaagttcca gggcagagtc acgtttaccg cggacacgtc cataagcaca gcctacatgg
      361 agctgagcag cctgagatct gaggacacgg ccgtgtatta ttgtgcgaaa tccgtgaatt
      421 acgaggaaga taacggttac tatataccga cgcagtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01005412             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8935:13921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005412
VERSION     KCXD01005412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8935:13921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63894.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       403..410
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          134 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 ggccccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctatggta gtactgggag caccggctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagttga actctgtgat
      361 cgccgcggac accgccgtgt attactgtgc gagatatgga gatgatagtg ttcattacaa
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005413             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16362:4573
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005413
VERSION     KCXD01005413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16362:4573"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63895.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       418..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          146 c          139 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcaac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accggattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggcgttgatc ctgcatatgg tgaatttaca
      301 cccggagaga agttccaggg cagagtcacc atgaccgagg acacgtctat agacacagcc
      361 tacatggagc tgagcagcct gaactctgag gacacggccg tctattactg tgcagccggg
      421 tatagcggca gctggaacca ctggtacttc gatctctggg gccctggcac ccctatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005414             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17593:13264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005414
VERSION     KCXD01005414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17593:13264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..503
     V_segment       133..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63896.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       448..453
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>507
                     /gene="IGHG"
BASE COUNT          103 a          128 c          156 g          120 t
ORIGIN      
        1 acatggggag acaggagcct tagccctgga ttccaagaac ttccactttg ggatcagctc
       61 tgaacacaga ggaccatgga gttggggctg agctgggttt tccttgttgc tattttaaaa
      121 ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggtcca gcctgggggg
      181 tccctgagac tctcctgtgc agcctctgga ttcacctttg gtgattatgg catgcactgg
      241 gtccgccagg ctccgggaaa gggactggag tgggtctcat ccattaggaa cactggtaaa
      301 atcgtatact acgctgactc cgtgaagggc cgattcacca tttccagaga caacgccaag
      361 aactcgctgt ctctgcgaat gagcagcctg agagccgagg acacggccgt gtactactgt
      421 actagaattg gcgtcggatc tctggcaact gctggtgact actttgacca ctggggccag
      481 ggagtcctgg tcaccgtctc ctccgcc
//
LOCUS       KCXD01005415             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16238:15975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005415
VERSION     KCXD01005415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16238:15975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63897.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       445..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          115 c          157 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc ggcctctgga ttcaccttca gaacctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgaa
      301 tgatgaaact aacaaatact acggagactc tgtgaagggc cgattcagca tctccagaga
      361 caattcgaag aacatgctat atcttcaaat gaacaccctg aaattggagg acacggccgt
      421 gtattactgt gcgacagatg cgtttggtag tgggattgac cactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005416             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:10752:12374
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005416
VERSION     KCXD01005416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:10752:12374"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..473
     V_segment       120..413
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63898.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       417..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>476
                     /gene="IGHG"
BASE COUNT          101 a          147 c          123 g          105 t
ORIGIN      
        1 acatggggtc tccctcaccg cacagctggg atctcagtgc ttcatttctg tcctccacca
       61 cgatggggtc aactgccatc ctcgccctcc tcctggctgt tctccaagga gtctgtgccg
      121 aggtgcagct ggtgcagtct ggaacagagg tgaaaaggcc cggggagtct ctgaggatct
      181 cctgtcagac ctctggatac aactttccca gcagctggat cacctgggtg cgccagatgc
      241 ccgggaaagg cctggagtgg atggggacca tctatcctgc tgattctaat gccaaataca
      301 acccgtcctt ccaaggccac gtcactatct cagtcgacaa gtccatcagc accacctact
      361 tgcagtggag caacctgaag gcctcggaca ccgccacgta ttactgtgcc aaaacctact
      421 atagtggtag tttggaatac tggggccagg gagtcctggt caccgtctcc tcaacc
//
LOCUS       KCXD01005417             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4961:6202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005417
VERSION     KCXD01005417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4961:6202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63899.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       424..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          137 c          150 g           97 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gaccggggct gcggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctatg tcatcaattg ggtgcgccag gcccctggac
      241 aagggctaga gtggatggga gggatcatcc ctcttgttgg tacaacaaac tacgcacaga
      301 ggttccaggg cagagtcacg attattgcgg acacgtccac aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagaggc ccccctactg
      421 aagggggtga ttattctggg ggggctttga gccgatgggg ccagggagtc caggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005418             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22004:9173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005418
VERSION     KCXD01005418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22004:9173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63900.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       401..407
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           84 a          137 c          145 g           98 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg caacttcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtccccaggg aaggggctgg
      241 agtggattgg gtttttcggt ggtcgcaatg ggaacaccta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcacca gacacgtcca agaaccagtt ctccctgagg ctgaggtctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgaggga ggggatatca gcggcggggg
      421 tcgactactg gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005419             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10701:4761
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005419
VERSION     KCXD01005419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10701:4761"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..443
     V_segment       89..382
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63901.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       383..388
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          104 a          102 c          128 g          111 t
ORIGIN      
        1 acatgggagc acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct
       61 tgttgctatt ttaagaggtg tccggtgtga ggtacaactg gtggagtctg gaggaggctt
      121 ggttcagcct ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtaa
      181 ctttggcttg cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat
      241 ttcgtctgat ggaactaaga aatactacgt aaactctata aaggaccgat tcaccatctc
      301 cagagacaat tccaagaaca tactatatct ccaaatgaac aacctgaaat tggaggacac
      361 ggccgtctat tactgtgcga gagatgatct tgggaccggt tttgactact ggggccaggg
      421 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005420             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9359:8491
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005420
VERSION     KCXD01005420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9359:8491"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63902.1"
                     /translation="CAAGYSGNWNQWYFDLW"
     D_segment       418..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          117 a          144 c          136 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgcatatgg tgaatttaca
      301 cccggagaga atttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagcct gaactctgag gacacggccg tatattactg tgcagccggg
      421 tatagcggca actggaacca gtggtacttc gatctctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005421             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12494:20773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005421
VERSION     KCXD01005421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12494:20773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..410
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63903.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       422..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          119 a          138 c          139 g          101 t
ORIGIN      
        1 acatggggaa caactgcatc caacctcaag agaagcccct gagagcacag tttctcacca
       61 tggacttgac ctggaagatc ctcctcttgg tgacagcagc cacaggtgcc cactcccagg
      121 tgcaactggt gcagtctggg ggtgagatta agcagcctgg ggcctcagtg aagctctcct
      181 gtcaggcttc tggatattcc ctcactcact acttcatgca ctgggtgaga caggcccctg
      241 gacagggcct tgagtggata ggactgatca cccctcacaa tgatcataaa gtctacgcac
      301 agaacttcca gggcagagtc accataacta cggacacgtc cacgagcaca gtgtccatgg
      361 agctgagcag cctgagatcc gaagacacag ccgtatacta ctgtgcgaga gggggggaca
      421 tagaatattg tactggtagt ggttgtgggg agcttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005422             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22658:18524
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005422
VERSION     KCXD01005422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22658:18524"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..466
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63904.1"
                     /translation="CARYCTSSTCFHFDYW"
     D_segment       401..422
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>472
                     /gene="IGHG"
BASE COUNT           91 a          140 c          131 g          110 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg
      181 tgactctatc accagtactc actggtggac ctggatccgc cagccccccg ggaaagggct
      241 ggagtggatt gggtatgtca gtggtagtac tggtagcgcc ttctacaacc cctccctcaa
      301 gagtcgagtc accatttcaa cagacacgtc gaagaaccag ttctccctga agctgagctc
      361 tgtgaccgcc gcagacacgg ccgtgtatta ctgtgcgaga tattgtacta gtagtacttg
      421 ctttcacttt gactactggg gccagggagt cctggtcacc gtctccccag cc
//
LOCUS       KCXD01005423             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13149:6886
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005423
VERSION     KCXD01005423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13149:6886"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63905.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          119 a          111 c          158 g          127 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc tgctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agtggctttg
      241 gcatacactg ggtccgccag gctcctggga aggggctgga gtgggtgtca cttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcatc atgtccagag
      361 acaattccaa gaacaaggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagtt agtggtcata cagagggtac agttgaaaac tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005424             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:11855:15019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005424
VERSION     KCXD01005424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:11855:15019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63906.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          139 c          131 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtagtagtgg gaccacctac tacaacccct ccctcaagag
      301 tcgagccacc atttcaaaag acacgtccaa gaatcaactc tccctgaagc tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgccagagat gaagacccct ccatttttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005425             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12452:17850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005425
VERSION     KCXD01005425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12452:17850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63907.1"
                     /translation="CARSWGRWSAEYVDFW"
     D_segment       446..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          118 c          152 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagtct ttgctgagct ggattttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tatcaggtat tagcattggc
      301 ggtaccacat actacccaga cgctatgaag ggtcgattca ccatctccag agacaatacc
      361 gagaagtcct tgtatcttca aatgaacagc ctgagagctg aggacactgc tgtgtatttt
      421 tgtgcaagat catggggcag gtggtcagcg gaatacgtcg acttctgggg ccagggcgcc
      481 ctggtcattg tctcctcagc c
//
LOCUS       KCXD01005426             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12396:20014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005426
VERSION     KCXD01005426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12396:20014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63908.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       421..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          104 a          138 c          144 g           98 t
ORIGIN      
        1 atggggacat aacaaccacc tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacctg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccagctg gtgcagtccg gggctgatgt gaagaagcct ggggcctcag tgaaactctc
      181 ctgcaaggct tctggattcg ccttcagaat gtatgccctc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagggat cgtcccgctt gttggaacaa caaactccgc
      301 acagaagttc cagggcagag tcacgattac cgcggacacg tccataagca cagtctacat
      361 ggaactgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcga gaggcctggg
      421 tagcagcgcc cactttggtt tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01005427             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14635:3339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005427
VERSION     KCXD01005427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14635:3339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63909.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       440..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          114 a          114 c          161 g          126 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc tgctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtggctttg
      241 gcatacactg ggtccgccag gctcctggga aggggctgga gtgggtgtca cttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ttgtccagag
      361 acaattccaa gaacatggta tatcttcaca tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagtt agtgggcata cagaggggac agttgaaaac tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005428             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14901:7057
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005428
VERSION     KCXD01005428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14901:7057"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63910.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          119 c          149 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gagtgaggtg caactggtgg agtccggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cactaactat
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg agtgggtggc agttatttcg
      301 tctgatggaa gtaagaaata ctacgcaacc tctgtgaggg accgcttcac catctccaga
      361 gacaattcca agaacatact ttatcttcaa atgaacaacc tgaaattgga agacacggcc
      421 gtctattact gtgcgagaga tgatattggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005429             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11795:11860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005429
VERSION     KCXD01005429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11795:11860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63911.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          114 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc ctttcggtga
       61 tcagcacaga acacagagga ctcaccatga tgtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttg
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaag taagacatat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtt catcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tgttttactg tgcgagagat gtccggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005430             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24928:18707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005430
VERSION     KCXD01005430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24928:18707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63912.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       409..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          106 a          144 c          136 g           89 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccctcaccga attgtccact cactgggtgc gacgggcccc
      241 cggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc cacagacaca gcctacatgg aactgagcag
      361 cctaagatct gaggacacgg ccgtgtatta ctgtgcgatt ggccctaccg gcaggtggaa
      421 cggctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01005431             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10685:14557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005431
VERSION     KCXD01005431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10685:14557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63913.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          120 a          145 c          142 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg agttgttaat cctgtaaatg gtgaaataat
      301 acacgcagac aatttccagg ccagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgaccagtc tgagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcggt agcagcgtct ggtccagcct cttcaacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005432             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18124:6073
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005432
VERSION     KCXD01005432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18124:6073"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63914.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          117 c          145 g          130 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggaatctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtac ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tttccggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtacaaggg ggatagataa ctaccacttt agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005433             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7086:12368
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005433
VERSION     KCXD01005433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7086:12368"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63915.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          112 a          141 c          131 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agttggtaca gtctggggtt gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggag aaggacttga gtggatggga ggtgttcatc ctgaatttgg taaagtagac
      301 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga cttctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005434             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20229:9882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005434
VERSION     KCXD01005434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20229:9882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63916.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          121 c          153 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cggcctgggg ggtccctgag actctcctgt ggagcctctg gattcacctt cagtaatttt
      241 ggcatccact gggtccgcca ggctccaggg aagggcctgg agtgggtggc agttatatcg
      301 tctgatgaaa gtaagaaata ctatgcagac tcggtgaagg accgattcac catctccaga
      361 gacaattcca agaacattct atatcttcaa atgaacaacc tgaagttgga cgacacggcc
      421 gtctactact gcgcgagaga cgcatttggc agcggctgtg actactgggg ccggggcgtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005435             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:17523:9496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005435
VERSION     KCXD01005435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:17523:9496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..397
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63917.1"
                     /translation="CSSGRRQLDFDYW"
     D_segment       407..412
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           90 a          134 c          132 g          105 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagcta cagttgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc tgtcacctgc gctgtctctg
      181 gtggctctat caacatttac tactggaatt ggatccgcct ggccccaggg aagggactgg
      241 actggattgg acatatctat ggtagcggtg ggagcaccat ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtt ctccctgaac ctgaggtctg
      361 tgaccgccgc ggacacggcc gtgtattact gttcgagcgg tcggcgacag ttggactttg
      421 actactgggg ccggggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005436             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5861:8271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005436
VERSION     KCXD01005436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5861:8271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63918.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..411
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          138 c          138 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagatctcc ctgaaagtga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gacagccgga tatagcagca gtgaaagctt
      421 ctacggtttg gattcgtggg gccaaggggt cgtcgtctcc gtctcctcag cc
//
LOCUS       KCXD01005437             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19556:14427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005437
VERSION     KCXD01005437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19556:14427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63919.1"
                     /translation="CARGPNYEDDNGYQTGFDSW"
     D_segment       415..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          139 c          139 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggaacccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc aacatctatg ccatcacttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tataacaaac tacgcacaga
      301 agttccaggg cagagtttcg attaccgcgg acacgcccac aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgcgagaggt cctaattacg
      421 aggatgataa cggataccag accggttttg actcctgggg cccgggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005438             415 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9903:15918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005438
VERSION     KCXD01005438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 415)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 415)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9903:15918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    47..413
                     /note="immunoglobulin heavy chain variable region"
     V_region        47..413
     V_segment       47..340
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <332..>382
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63920.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       351..363
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       372..413
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        414..>415
                     /gene="IGHG"
BASE COUNT           87 a          101 c          127 g          100 t
ORIGIN      
        1 acatgggggg gttttccttg ctgctatttt aaaaggtgtc cagggtgagg tgcagctggt
       61 ggaatctggg ggcggcttgg caaagcctgg ggggtccctg agactctcct gtgcagcctc
      121 tggattcacc ctcagtaact actggatgta ctgggttcgc caggcaccag ggaaggggct
      181 ggagtggatc tcagctatta acagtgttgg tgataccaca tactatgcag actccgtgaa
      241 gggcagattc accatctcca gagagaacgc caagaacact ctgtatcttc aaatggacag
      301 cctgagagct gaggacacgg ctatctatta ctgtgcgaga gttccgggcc tagtggtatt
      361 taccggttcg cttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005439             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:21543:6459
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005439
VERSION     KCXD01005439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:21543:6459"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63921.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          117 c          153 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtactttcgt
      301 ctgatggaaa taagaagtac tacgcagact ctgtgaagga ccgattcatc atctccagag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtttttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005440             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:7524:4273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005440
VERSION     KCXD01005440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:7524:4273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63922.1"
                     /translation="CVRYEDEAINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          137 c          130 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tgactccatc accagtagct actggaactg gatccgccag ccccccggga agggactgga
      241 atggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcagc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaag ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005441             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24657:18382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005441
VERSION     KCXD01005441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24657:18382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63923.1"
                     /translation="CATADYGNSLDFW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          117 c          149 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca attggtggag actgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcatc
      301 tgatggaatt atgagctact actcagacgc tatgaaggac cgatttacca tctccagaga
      361 caattccaag aacatgctat atcttcaagt gaacaacctg aagttggagg acactgccgt
      421 ttattactgt gcgacagccg actacggtaa cagccttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005442             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11538:10787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005442
VERSION     KCXD01005442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11538:10787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63924.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       409..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          149 c          132 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtctccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      301 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg gttggcccta gcggcacttg
      421 gaaccactgg tccttcgata tctggggccc tggcacccca gtcaccatct cctcagcc
//
LOCUS       KCXD01005443             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8555:6205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005443
VERSION     KCXD01005443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8555:6205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..469
     V_segment       112..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63925.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       410..415
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..469
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          109 a          107 c          139 g          116 t
ORIGIN      
        1 acatggggca cagtgttcca ttcggtgatc agcacagaac acagaggact caccatgaag
       61 tttgggctga gctgggtttt ccttgttgct attttaagag gtgtccagtg tgaggtgcag
      121 ctggtggagt ctggaggagg cttggttcag cctggggggt ccctgagact ctcctgtgca
      181 gccactggat tcaccttcag tagctatggc atgcactggg tccgccaggc tccagggaag
      241 gggctggagt gggtggcagt tatatcatac gatgaaaata agaaatacta cgcagactct
      301 ctgagggacc gattcaccat ctccagagac aattccaaga acatgcttta tcttcaaatg
      361 aacaacctga aattggagga cacggccgtt tattactgtg cgaggaggcc ctggagtgca
      421 gatgcttttg atttctgggg ccaaggactc agggtcaccg tctcttcagc c
//
LOCUS       KCXD01005444             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10942:18397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005444
VERSION     KCXD01005444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10942:18397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63926.1"
                     /translation="CATAHSGRWINWYFEIW"
     D_segment       424..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          119 a          141 c          137 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagcagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccattcac tgggtgcgac
      241 aggcccctgg aaaggggctt gaatggatgg gaagtgttga tcctgtttat ggtgaaatga
      301 taaacgcaga gaagttcccg ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gttggtcagt ctgcgatctg aggacacggc cgtgtattac tgtgcaacag
      421 cccatagcgg caggtggatt aactggtact tcgaaatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01005445             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17503:6861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005445
VERSION     KCXD01005445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17503:6861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..482
     V_segment       116..405
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63927.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       423..431
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          109 a          109 c          139 g          127 t
ORIGIN      
        1 acatgggatt cccaggtgtt ttcattcaga gatcaggact gaacacacag gactcaccat
       61 ggagtttatg ctgagctggg ttttccttgt tgctatgtta aaaggtgtcc agtgtgtgga
      121 gcagctggtg gaatctgggg gaggcttggt acagcctggg gcgtccctga gactctcctg
      181 tgcagcctct ggattcacct tcagtagctt tgacatgcac tgggttcgcc aggctccagg
      241 gaagggtctg gactgggtat caggtattaa cattggcggt gacacatact acccagactc
      301 tgtgaagggt cgattcacta tgtccagaga caatgccaag aactccgtgt atcttcaaat
      361 gaacagcctg agagttgagg acactgctgt gtatttttgt gcaaggggga tagataacta
      421 ccactatagt gatacggact ttgactactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01005446             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14563:8925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005446
VERSION     KCXD01005446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14563:8925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..442
     V_segment       85..381
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63928.1"
                     /translation="CARDEDPSIFDHW"
     D_segment       392..396
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           86 a          132 c          127 g           99 t
ORIGIN      
        1 acatgggggg acatcctgtg caagaacatg aagcacctgt ggttcttcct cttcctggtg
       61 gcagctccca gatgggtcct gtcccaggtg cagctgcagg agtcgggccc aggactggtg
      121 aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtggcgccat cagcaggggt
      181 ttctactgga cctggatccg ccaaccccca gggaaggggc tggagtggat tgggtgtatc
      241 ggtggtagta gtggtaccac ctattataac ccctccctca agagtcgagc ctccatttca
      301 aaagacacgt ccaacaatca actctccctg aagctgagtt ctgtgaccgt cgcggacacg
      361 gccgtgtatt actgtgcgag agatgaagac ccctccattt ttgaccactg gggccaggga
      421 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005447             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15078:15072
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005447
VERSION     KCXD01005447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15078:15072"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63929.1"
                     /translation="CATGRIGSSGWSNLFTGLESW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          147 c          145 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggatggga gttgttgatc ctgtcaatgg tgaagaaatt
      301 cacgcagaga aattccaggg cagagtcacc ttgaccgagg acacgtccac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcggctg gtccaacctc ttcaccggtt tggaatcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005448             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7175:10609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005448
VERSION     KCXD01005448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7175:10609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63930.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       452..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          117 c          152 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg actgggtatc aggtattaac
      301 attggcggtg acacgtacta cccagactct gtgaagggtc gattcactat gtccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatagtg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005449             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:7115:9791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005449
VERSION     KCXD01005449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:7115:9791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63931.1"
                     /translation="CARYEAGTTLIDYW"
     D_segment       400..411
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           91 a          140 c          130 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccgtcacc agcacctact ggagctggat ccgccagccc ccagggaaag gactggagtg
      241 gattggctat atctatggtg gtagtgggag taccggctac aacccctccc tcaggagtcg
      301 agtcgacatt tcgacagaca cgtccaacaa ccagttttcc ctgaagctga gctctgtgac
      361 cgccgcggac accgccgtct actactgtgc gagatatgaa gctggaacaa ccctaattga
      421 ctactggggc cagggagtcc tggtcatcgt ctcctcagcc
//
LOCUS       KCXD01005450             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14286:7634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005450
VERSION     KCXD01005450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14286:7634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63932.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          142 c          148 g           97 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgagatcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcca ggtgtccgga tacacgttca gtgaaatctc catgcactgg gtgcgacaga
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggaact gagtagcctg agatctgacg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005451             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22389:16590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005451
VERSION     KCXD01005451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22389:16590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63933.1"
                     /translation="CARRGIAAGWSFDYW"
     D_segment       438..448
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          120 c          160 g          110 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtacagctgg tggagtctgg gggcggcttg gcaaagccgg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttcc tactacatga
      241 actgggtccg ccaggctcca ggaaaggggc tggagtggat ctcaggtgtt aacagcggtg
      301 gggagagtac atactatgca gactccgtgg agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagacc tgaggacacg gctgtctatt
      421 actgtgcgag aagagggata gcagctggat ggagctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005452             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15647:5738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005452
VERSION     KCXD01005452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15647:5738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..494
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63934.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       414..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          109 a          136 c          146 g          109 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 agacttctgg atacaccttc agcatctctg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttgg gtggatggga gggatcatcc ctcttgttgg tgtgacaaac tacgaacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc ttcatggaac
      361 tgagcagcct gagatctgag gacacggccg tctactattg tgcgacaggg gtatattacc
      421 aggatgaata cggttatttt tatgtcggcg gtgactttga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01005453             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19846:4855
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005453
VERSION     KCXD01005453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19846:4855"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63935.1"
                     /translation="CAIGPSGSWNNWSFDIW"
     D_segment       416..427
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          107 a          138 c          133 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt cttatgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgagttgtcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtggcaag tgttgatcct gcatatggtg aaatgatgtt
      301 ccagggtaga gtcaccatga ctgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaga tctgaggaca cggccgtgta ttactgtgcg attggcccta gtggcagctg
      421 gaacaactgg tccttcgata tctggggccg tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01005454             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17022:13657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005454
VERSION     KCXD01005454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17022:13657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63936.1"
                     /translation="CANALSGGLDYW"
     D_segment       444..449
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          100 a          127 c          163 g          107 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggtact
      241 ggatgaactg ggtccgccag gcgccaggga aggggctgga gtgggtctca gctattacta
      301 gtggtggcga cagcacatac tacgctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaactctag gaatacgctc tccctgcaaa tgaacagcct tagagcggag gacacggccg
      421 tgtactactg tgcgaacgcg ttaagtgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005455             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7269:11802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005455
VERSION     KCXD01005455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7269:11802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..309
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..309
     V_segment       8..248
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63937.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       258..263
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       267..309
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        310..>311
                     /gene="IGHG"
BASE COUNT           77 a           74 c           89 g           71 t
ORIGIN      
        1 acatggggag actctcctgt gcagcctctg gattcacctt cagtaacttt ggcatacact
       61 gggtccgcca gggtccaggg aaggggctgg agtgggtggc agttatatcg tatgatgaaa
      121 ctaggacata ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      181 agaacatgat atttcttcaa atgaacaacc tgaaattgga ggacacggcc gtgtattact
      241 gtgcgagaga tgtcagggga acggggtttg actactgggg ccagggagtc ctggtccccg
      301 tctcctcagc c
//
LOCUS       KCXD01005456             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12496:10894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005456
VERSION     KCXD01005456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12496:10894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63938.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          118 c          149 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtatgatg
      301 agactaagaa atactacgca gactctgtga agggccgatt caccatctcc agagacaatt
      361 ccaaaaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgcgag agattcttac ggtcgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005457             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12937:13533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005457
VERSION     KCXD01005457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12937:13533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63939.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          115 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaaggc ccgattcacc gtctccagag
      361 acaattccaa gaacatgtta tatcttcaaa cggacaacct gaaattggaa gacacggccg
      421 tgtattactg cgcgagagat gtctggggga ggggatttga ctattggggc cagggaatcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005458             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:11006:9770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005458
VERSION     KCXD01005458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:11006:9770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63940.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           96 a          148 c          145 g          109 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaagtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggctgggg gcgattgatc ctggtgactc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagtaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005459             414 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:12122:4968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005459
VERSION     KCXD01005459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 414)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 414)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:12122:4968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    52..412
                     /note="immunoglobulin heavy chain variable region"
     V_region        52..412
     V_segment       52..345
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <337..>381
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63941.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       346..350
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       366..412
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        413..>414
                     /gene="IGHG"
BASE COUNT           84 a          100 c          134 g           96 t
ORIGIN      
        1 acatgggtga gctgggtttt ccttgttgct cttttgaaag gtgtccagtg tgaggtgcag
       61 ctggtggagt ctgggggcgg cttggcaaag cctggggggt ccctgagact ctcctgcgca
      121 gcctctggat tcaacttcaa ttactactac atgaactggg tccgccaggc tccagggaag
      181 gggctggagt ggatctcagg tattaacagt ggtggggata gcacatacta tgcggactcc
      241 gtgaagggca gattcaccat ctccagagag aacgccaaga acacactgta tcttcaaatg
      301 gacagcctga gagctgagga cacggctgtc tattactgtg cgagagtggt gggtggtgcc
      361 gcaggatact tcgacttctg gggccagggc gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005460             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15130:10269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005460
VERSION     KCXD01005460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15130:10269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63942.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           90 a          138 c          132 g          102 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt gggaccacct actacaaccc ctccctcaag
      301 agtcgagccg ccatttcaaa agacacgtcc aacaatcaat tctccctgag gttgagttct
      361 ctgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005461             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12559:15942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005461
VERSION     KCXD01005461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12559:15942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63943.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          115 a          138 c          153 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctggaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 ggggttcggt agcagtgtct ggtccaatct cgtttatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01005462             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13895:14651
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005462
VERSION     KCXD01005462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13895:14651"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..496
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63944.1"
                     /translation="CATADYGNSLDYW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>499
                     /gene="IGHG"
BASE COUNT          113 a          119 c          147 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt atgaaatact acgcagactc tatgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaagaacctg aaattggagg acactgccgt
      421 ctattattgt gcgacagccg actacggtaa cagccttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01005463             411 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13106:11999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005463
VERSION     KCXD01005463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 411)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 411)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13106:11999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    55..407
                     /note="immunoglobulin heavy chain variable region"
     V_region        55..407
     V_segment       55..348
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <340..>378
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63945.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       351..359
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       370..407
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        408..>411
                     /gene="IGHG"
BASE COUNT           91 a           91 c          129 g          100 t
ORIGIN      
        1 acatgggggc tgagctgggt tttccttgtt gctattttaa gaggtgtcca gtgtgaggtg
       61 cagctggtgg agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt
      121 gcagcctctg gattcacctt cagttactat ggcatgcact gggtccgcca ggctccaggg
      181 aaggggctgg agtgggtggc agttatgtcg aatgatggaa ctaagaaata ctacggagac
      241 tctgtgaagg accgattcac catctccaga gacaattcca agaacaggct atatcttcaa
      301 atgaacaacc tgaaattgga ggacacggca gtctattact gtgcgagaga tgatagtggg
      361 gtgatcatcg actactgggg ccagggagtc ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01005464             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12312:12261
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005464
VERSION     KCXD01005464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12312:12261"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63946.1"
                     /translation="CTRDVRGTGFDYW"
     D_segment       439..444
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          116 c          145 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctacttta
      121 agaggtgtcc agtgtgacgt gcagctggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tacagcctct ggattcacct tcagtacctt tggcatacac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtatgatgaa
      301 actaagcaat attacgcaga ctctgtgaag gaccgattca ccctctccag agacaattcc
      361 aagaatatgc tatatcttca aatgaacaac ctgaaactgg aggacacggc cgtttattac
      421 tgtacgagag atgtcagagg aacggggttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01005465             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14083:10544
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005465
VERSION     KCXD01005465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14083:10544"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63947.1"
                     /translation="CTRIWCPRDLRSGCNWFDVW"
     D_segment       458..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          106 a          129 c          157 g          125 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggagcacct cgtggagtct gggggaggcc tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagg ctctggattc atctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaagggg actggagtgg gtctcgtcca ttagtaacac
      301 tggtaaaact atatactaca ctgactccgt ggagggccga ttcaccatct ccagagacaa
      361 cgcccagaac tcggtgtctc tgcaaatgag cagcctgaga gccgaggaca cggccctata
      421 ttactgtact agaatttggt gtccccgcga tttaagaagc ggctgtaatt ggttcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005466             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5201:9700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005466
VERSION     KCXD01005466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5201:9700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..325
     V_segment       7..253
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <247..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63948.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       262..273
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..325
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           69 a           93 c           94 g           71 t
ORIGIN      
        1 acatgggggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
       61 gctatacact gggtccgcca ggctcccggg aaggggctgg agtgggtctc agccattagt
      121 agtggtggta gcacatacta cgcagactcc atgaagggcc gagccaccat ctccagagac
      181 aactcaaaga acacggtctc cctgcaagtg aacagcctga cttctgagga cacggccgtg
      241 ttttactgtg cgagagggga gacagcttca gtttactacg ctttggattc ctggggccaa
      301 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005467             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11689:2928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005467
VERSION     KCXD01005467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11689:2928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63949.1"
                     /translation="CAKTYYSGTLEFW"
     D_segment       416..428
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..473
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          146 c          129 g          107 t
ORIGIN      
        1 acatggggct ccctcaccgc acagctggga tctcagttct tcatttctgt cctccaccac
       61 gatggggtca actgccatcc tcgccctcct cctggctgtt ctccaaggag tctgtgccga
      121 ggtgcagctg gtgcagtctg gggcagaggt gagaaggccc ggggagtctc tgaggatctc
      181 ctgtaagact tctggataca gctttaccac cagctgggtc agttgggtgc gccagatgcc
      241 cgggaaaggc ctggagtgga tggggaccat ctatcctgct gattctgagg ccaaatacaa
      301 cccctccttc caaggccacg tcactatctc agtcgacaac tccatcagta ccacctacct
      361 gcattggagc agcctgaagg cctcggacac cgccacatat ttctgtgcga aaacctacta
      421 tagtggtact ttggagttct ggggccaggg agccctggtc accgtcgcct cagcc
//
LOCUS       KCXD01005468             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:22487:16445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005468
VERSION     KCXD01005468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:22487:16445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63950.1"
                     /translation="CSRYTPGTTVFDYW"
     D_segment       398..408
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           93 a          143 c          125 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tcactggtga
      181 ctccatcacc agtacctact gggcctggat ccgccagccc cccgggaagg ggctggagtg
      241 gattggctac atctacggtg gtacagagag caccggctac aacccctcac tcaagagtcg
      301 ggtcaccatt tcaacagaca cgtccaagaa ccagttttac ctgaacatga ggtctattac
      361 cgccgcggac accgccgttt atttctgttc gagatacaca cctggaacaa cggtctttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005469             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18174:5032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005469
VERSION     KCXD01005469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18174:5032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63951.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          153 g          119 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtgg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaacttggag gacacggccg
      421 tctattactg tgcgagggac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005470             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17958:3892
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005470
VERSION     KCXD01005470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17958:3892"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63952.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       410..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          117 a          141 c          127 g           99 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaagt ggagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggaacca ccttcaccga attatccctg cactgggttc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagttt taatcctata tatggtgaaa ttttacacac
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtgtat tactgtgcgg cagctgatag
      421 tggttaccca ttttactact tcgatatctg gggccctggc accccaatca ccatctcctc
      481 agcc
//
LOCUS       KCXD01005471             379 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13086:16253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005471
VERSION     KCXD01005471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 379)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 379)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13086:16253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..377
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..377
     V_segment       8..301
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>346
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63953.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       303..309
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       336..377
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        378..>379
                     /gene="IGHG"
BASE COUNT           84 a           93 c          120 g           82 t
ORIGIN      
        1 acatggggag gtccacctgg tgcagtctgg ggctgaagtg aagaagcctg gggcctcagt
       61 gaaggtctcc tgcaaagttt ccggatacac cttcaccgat ttatccatgc actgggtgcg
      121 acaggcccct ggaaaagggc ttgagtggat gggaggtgtt gatactgtat ctgatggagt
      181 gatatacgca gagaacttcc agggcagagt caccatgacc gaggacacgt ctacagacac
      241 agcctacatg gagctgagca gcctgagatc tgaggacacg gccgtttatt actgtgcgag
      301 aggtgtgaca gcagacgtct tcggtttcct cgggcttgac tactggggcc agggagtcct
      361 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005472             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11796:18195
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005472
VERSION     KCXD01005472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11796:18195"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63954.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       424..433
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           99 a          144 c          131 g          109 t
ORIGIN      
        1 acatgggggc tccctcaccg cacagctggg atctcagtgc ttccttttct gtcctccacc
       61 acgatggggt caactgccat cctcaccctc ctactggctg ttctccaagg agtctgtgcc
      121 gaggtgcagc tggtgcagtc tggagcagag gtgaaaaggc ccggggagtc tctgaagatc
      181 tcctgtaaga cttctggata cagctttacc agttactgga tcacctgggt gcgccagatg
      241 cccgggaaag gcctggagtg gatgggggcg attgatccta gtgattctgc taccaaatac
      301 agcccgtcct tccaaggcca ggtcaccatt tcagccgaca agtccatcac caccgcctac
      361 ctagaatgga gcagcctgaa ggcctcggac accgccacgt atttttgtgc gaaaggtccc
      421 ggagtgatta ttaactactt tgactactgg ggccagggag ccctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01005473             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5759:6209
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005473
VERSION     KCXD01005473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5759:6209"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63955.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       426..431
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          114 a          141 c          141 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagag gcctggggcc tcagttaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaaatatc catgcactgg gtgcgacagg
      241 cccccggaaa aggacttgag tggatgggaa gtgttgatcc tgtgtatagt gaagaaatac
      301 tcgcagataa tttccacgac agagtcacca tgaccgagga cacgtctaca ggcacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt atatttctgt gcggcgggcc
      421 ttggggggta tctagtgctt actgaatacc tcgaattctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01005474             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23427:9243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005474
VERSION     KCXD01005474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23427:9243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63956.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       269..274
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           79 a           77 c           90 g           76 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
       61 tggcatccac tgggtccgcc aggctccagg gaaggggctg gagtgggtga cagttatatc
      121 gtatgatgaa acaaagaaat actacgcaga ctctctgaag gaccgcttca tcatctccag
      181 agacaattcc aagaacatgg tatatcttca aatgaataac ctgaaattgg atgacacggc
      241 cgtatattac tgtgtgagag atgtcagggg aacggggttt gacttctggg gccagggtgt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005475             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:24533:6119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005475
VERSION     KCXD01005475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:24533:6119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..469
     V_segment       100..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63957.1"
                     /translation="CARYSYGGSYFFGFFDFW"
     D_segment       394..402
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          134 c          132 g          114 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ttgtccctca cctgcgctgt ctctggtggc
      181 tccatcagca gtaactcctg gagctggatc cgccaggccc cagggaaggg gctggaatgg
      241 attggatata tctatggcgg tagtgggaac accacctaca acccctccct caagagtcga
      301 gtcaccattt caaaagacat gtccaagaac cagttttccc tgaagttgat ctctgtgacc
      361 gccgcggaca ccgccgtgta ttattgtgcg agatacagtt acggtggcag ctatttcttt
      421 gggttctttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005476             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15382:16494
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005476
VERSION     KCXD01005476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15382:16494"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63958.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       411..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          113 a          133 c          132 g          107 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacttgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggcgcag tctggggctg acgtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccttca ccgaattatc cctgcactgg gtgcgacagg
      241 gccctggaaa aggacttgag tggatgggag gttttgcttc tatatatggt gaattaatcc
      301 atgaaaggtt ccagggaaga gtcagtttga ccgaggacac gtccacagac acagcctata
      361 tggagctgag cagccttaga tctgaggaca cggccgtgta ttattgtgcg gcagctgata
      421 gtggttaccc attttactac ttcgatatct ggggccctgg caccccaatc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005477             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13834:12799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005477
VERSION     KCXD01005477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13834:12799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63959.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT           97 a          123 c          159 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcaactggt ggagtctggg ggcggcctgg cttggcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagt ttcagttact actacatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 gggtagcaca ttctatgcag actccgtgga gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtctcttc acatggacgg cctgagacct gaggactcgg ctgtttatta
      421 ctgtgcgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005478             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11345:16526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005478
VERSION     KCXD01005478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11345:16526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63960.1"
                     /translation="CARERCTSSVCAGFLDYW"
     D_segment       408..412
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          138 c          138 g          100 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag gtttcctgcg
      181 gggcttctgg attcaccttc gatacccatg gtatcaactg ggttcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatac cccttattgg tatcacaaac tacgcaaaga
      301 actctcaggg cagagtcaca ataagcgcga acacgtccac aaacacagcc tacatggagc
      361 tgaacagcct gagatctgag gacacggcca tctactactg tgcgagagaa cgctgcactt
      421 ctagtgtttg cgccgggttc cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005479             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:25693:13677
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005479
VERSION     KCXD01005479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:25693:13677"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63961.1"
                     /translation="CVRDSSWYNWDQDFDYW"
     D_segment       406..416
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           98 a          131 c          139 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgaaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtcact caaatgcgct gtctctggtg
      181 gctccatcac cgggaactac tggagttgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg taccactgat agtggtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcagcagac acgtccaaga accagttctc cctggagttg aggtctgtga
      361 ccgccgcgga cacggccgtg tattattgtg tgagagatag tagttggtat aactgggacc
      421 aagactttga ctattggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005480             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17874:22296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005480
VERSION     KCXD01005480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17874:22296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..416
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63962.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       426..432
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..486
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT           97 a          121 c          148 g          122 t
ORIGIN      
        1 acatgggggc cccagaattc ccaggtgttt ctgttcggcg atcagcacta aacacagaac
       61 ataccatgga gtttgtgctg agctgggttt tccttgttgc tcttttgaaa ggtgtccagt
      121 gtgaggtgca gctggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
      181 tctcctgcgc agcctctgga ttcagcttca gttactactt catgagttgg gtccgccagt
      241 ctccagggaa ggggctggag tggatctcag gtatttccag tggtggggat agcacatact
      301 ctgcagactc cgtgaagggc agattcacca tttccagaga gaacgccaag accacactgt
      361 atcttcacat ggacagcctg agagctgagg acacggctgt ctattactgt gcaagagatc
      421 gacgtgtaca gtcgttatcc tggttcgatg tctggggccc gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01005481             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18363:16872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005481
VERSION     KCXD01005481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18363:16872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63963.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          141 c          150 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga gcttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaatagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005482             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22195:18997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005482
VERSION     KCXD01005482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22195:18997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63964.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       420..426
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          113 a          139 c          137 g          100 t
ORIGIN      
        1 acatggggac acacaacagc cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctgcagg cgcccgctct
      121 gaggttcagt tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcgagg tttccggata caccttcacc gaactgtcca tccactgggt gcgacaggcc
      241 cctggaaaag gccttgagtg gatgggaagt gttgatcctg aatatggtga aatgataaac
      301 gcagaaaagt tccagggcag agtcaccttg accgaggaca cgtctacagg aacggcctac
      361 atggagctga tcagcctgag atctgaagac acggccgtgt attactgtgc gacatcaccc
      421 agcggcaatt ggcttttttg gtacttcgat ttttggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01005483             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16241:11340
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005483
VERSION     KCXD01005483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16241:11340"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63965.1"
                     /translation="CAIGPSGTWNGWSFDVW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           99 a          144 c          139 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gtatatggtg aaatggtgtt
      301 ccagggcggg gtcaccatga ccgaggacac gtctacagac acagcctact tggagctcaa
      361 cagcctgagc tctgaagaca cggccgtgta ctactgtgcg attggcccta gcggcacctg
      421 gaacggctgg tccttcgatg tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01005484             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9017:12239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005484
VERSION     KCXD01005484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9017:12239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63966.1"
                     /translation="CAAGHSGSWNYWYFDFW"
     D_segment       428..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          140 c          143 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctgc agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg gggtgttgat cctgcatttg gtgaaatgat
      301 acacgtagag aggttccagg gcagagtcac cctgaccgag gacacgtcta cagatacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtttttct gtgcagccgg
      421 acatagtggc agctggaact actggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005485             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12470:19730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005485
VERSION     KCXD01005485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12470:19730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63967.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       400..407
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           80 a          138 c          132 g          113 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc gattacttct ggaactgggt ccgccagtcc ccagggaggg ggctggagtg
      241 gattggattt ttctatggtg ctactgggag caccggctac aacccctccc tcaagagtcg
      301 agtcaccttt tcagcagaca cgtcccagaa ccagttttcc ctgaggctga cctctgtgac
      361 cgccgcggac accgccgttt attattgtgc gagatatcag ggtgattcct tgtactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005486             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17636:15670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005486
VERSION     KCXD01005486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17636:15670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63968.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          134 c          135 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggttgcag ctcccagatg ggtcctgtcc cagctgcagg tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatac atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005487             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17100:18401
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005487
VERSION     KCXD01005487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17100:18401"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63969.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          115 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcactaac tttggcattc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgcatgatg
      301 aaactaagaa atattacgca gactctgtta gggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctggattt ggaggacacg gccgtgtatt
      421 actgtgcgag ggacgcattt ggcagcggct gtgactactg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005488             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18869:9890
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005488
VERSION     KCXD01005488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18869:9890"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63970.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       445..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          107 a          117 c          161 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacgttt
      241 ggcgtccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 aatgatggaa gtaaaaagta ccacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattccg aggccaagct atatcttcaa atgaacaagc tgaaagtgga ggacgcggcc
      421 gtgtactact gtgtgagaga cgcgtatggt tccggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01005489             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22297:14482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005489
VERSION     KCXD01005489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22297:14482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..489
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63971.1"
                     /translation="CAREFSPYDYFWSDFYSYYFDYL"
     D_segment       433..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT           97 a          144 c          134 g          116 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtgactcctt cagcggttac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gcatatcagt gggagtagtg ggagcaccga ctacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaca gacacgtcca agagccactt ctccctgaaa ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga gttttccccc tacgactatt
      421 tttggagtga tttttactct tactactttg actacttggg ccagggactc ctggtcaccg
      481 tctcctcagt c
//
LOCUS       KCXD01005490             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13632:17926
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005490
VERSION     KCXD01005490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13632:17926"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63972.1"
                     /translation="CASVRCTGYKYGPFDYW"
     D_segment       426..432
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          135 c          144 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgagat gaagaagcct ggggcctcag tgaaggtctc
      181 ctgtcaggtt ctcggacaca ccttcaccga attatgcatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgactgga tgggcggtgt tgatcctgta aatggtgaga tcatgtacgc
      301 agagaagttc caggacagag tcaccgtgac cgaggatacg tccacagaca cagtctacat
      361 ggagttgagc agcctgagat ctgaggacac ggccgtgtat tattgtgcga gtgtccggtg
      421 caccggctac aaatacggac cgtttgacta ctggggccag ggagccctgg tcatcgtctc
      481 ctcagcc
//
LOCUS       KCXD01005491             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23312:13495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005491
VERSION     KCXD01005491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23312:13495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63973.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       444..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          113 c          160 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgtta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcagc
      181 ccggggggtc actgagactg tcctgtgcag cctctggatt caccttcagt agctctggca
      241 tgcactgggt ccgccaggct ccagggaagg gactggagtg ggaggcactt atatctaatg
      301 atggaagtaa gaaatattac gcagactccg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctgtat cttcaaatga acaacctgaa attggatgac acggccgtgt
      421 attactgtgc gcgagttgga gagggtagtg gtggtgcgga ggactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005492             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12971:15284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005492
VERSION     KCXD01005492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12971:15284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63974.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       431..439
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          143 c          143 g           98 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcggctac aggtgcccat tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatccatg gcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tttaacacac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgcccac aagcacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggcct tttattactg tgcgagaggg acaacccacc
      421 tcgagatggc aactggaatc ggagactact ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005493             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8700:6232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005493
VERSION     KCXD01005493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8700:6232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63975.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          141 c          136 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tataccttca ccgaactgtc cattcattgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acgcagaaaa attccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggacct gatcagtctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcac ctggctatat tggtacttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01005494             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11306:3913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005494
VERSION     KCXD01005494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11306:3913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63976.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       433..437
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          117 c          149 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcatctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct ttggcatgca
      241 ctgggtccgc caggctccag gaaaggggct ggactgggtg gcagttatgt cgtctgatgg
      301 aaataacaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctctatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtatatta
      421 ctgtgcgaga gatgtctttg gcggggggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005495             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6928:18810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005495
VERSION     KCXD01005495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6928:18810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63977.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          107 a          127 c          155 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctctagggaa ggggctggag tggatctcag gtattaacgc
      301 tggtggggac accacatact atgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccaag aacacactgc accttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005496             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11621:15232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005496
VERSION     KCXD01005496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11621:15232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63978.1"
                     /translation="CVRDSSGSGFDYW"
     D_segment       438..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          111 c          148 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tctggcatac
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactataca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt cacatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agattcaagc ggttcgggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005497             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14562:15789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005497
VERSION     KCXD01005497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14562:15789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63979.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          125 c          148 g          104 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccccaca gaagccccag agcaaagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtatct ggttatttta cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01005498             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13116:16001
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005498
VERSION     KCXD01005498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13116:16001"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63980.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          115 c          148 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatagcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaactaagaa atactacgta gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatcaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01005499             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14200:6802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005499
VERSION     KCXD01005499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14200:6802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63981.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       443..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          120 c          149 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgaact gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ttttggcatc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtctgat
      301 ggaaataacc tatactacgc agactctctg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tggtgtatct tcaaatgaac aacctgaaat tggaggacac ggccgtctat
      421 tactgtgcga gagattcata tggcagcggc tccgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005500             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11155:5848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005500
VERSION     KCXD01005500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11155:5848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63982.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          111 a          142 c          134 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaataccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgta tattactgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005501             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5246:18346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005501
VERSION     KCXD01005501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5246:18346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63983.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       443..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          114 c          150 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagag cacagaggac tcaccatgaa gtttgggctg aactgggttt tccttgtttc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtatttttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggctg ttatatcgaa
      301 tgatggaagt aaaaaatact actcagactc tgtgaaggac cgattcacca tctccagaga
      361 caactccgag gccaatgtat atcttcaaat gaataacctg aagttagagg acacggccgt
      421 atattactgt gtgagagatg cgtatggttc cggcttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005502             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18976:14477
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005502
VERSION     KCXD01005502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18976:14477"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..492
     V_segment       102..392
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63984.1"
                     /translation="CALDAGFGETILVVDINMFPHFDSW"
     D_segment       414..436
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT           98 a          141 c          139 g          116 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgtgat gtctctggtg
      181 cctccatcag tacttcctgg tggacctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggga gatcaatggt tatagtggta gtttttactc caacccctcc ctcaacagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga accagttcgc cctgaaactg agctctgtga
      361 ccgccgcgga cacggccgta tattactgtg cgctagatgc cgggtttggg gaaacgatat
      421 tagtagtcga tattaatatg ttcccccact ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005503             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16470:20220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005503
VERSION     KCXD01005503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16470:20220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63985.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       410..417
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           96 a          149 c          123 g          104 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtac aagaacatgc agtatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agtcgtaact ggtggagttg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctctg gtagtcttgg aagcaccagt aacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagacat tcagaccccg caactactag
      421 ctggtacttc gatctctggg gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01005504             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12374:10744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005504
VERSION     KCXD01005504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12374:10744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63986.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          116 a          144 c          129 g           90 t
ORIGIN      
        1 acatggggca tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggg aaagtagact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccac ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005505             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:23454:15840
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005505
VERSION     KCXD01005505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:23454:15840"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..290
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63987.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       300..306
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..360
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           79 a           89 c          112 g           82 t
ORIGIN      
        1 acatgggggt ggagtctggg ggcggcttgg caaagcctgg ggggtccctg agactctcct
       61 gcgcagcctc tggattcagg ttcaattatt actacatgag ctgggtccgc caggctccag
      121 ggaaggggct ggagtggatc tcaggtatta atagtggtgg ggaaagcaca tactctgcag
      181 actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca ctatatcttc
      241 aaatggacag cctgatatct gaggacacgg ctgtctatta ctgtgtgaga gatcgacgtg
      301 tacagtcgtt atcctggttc gatgtctggg gcccgggagc cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01005506             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12714:5281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005506
VERSION     KCXD01005506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12714:5281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..448
     V_segment       85..384
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63988.1"
                     /translation="CARRIRGGWPYFDFW"
     D_segment       394..398
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           96 a          138 c          115 g          101 t
ORIGIN      
        1 acatgggggt gactcctgtg ccccaccatg gacacgcttt gctccacgct cctgctgctg
       61 accgtcccgt cctgggtctt gtcccaggtg accttgaagg agtctggtcc tgcgctggtg
      121 aaacccacac agaccctcac gctgacctgc gccgtctctg ggttctcact caacaatatt
      181 ggtatggggg tgggctggat ccgtcagccc tcaggaaaga ccctggagtg gcttgcacac
      241 atttactggg atgataacaa gctctacagc acatctctaa agaacagact caccatctcc
      301 agggacacct ccaaaaacct ggtacttctg acaatgacca acatggaccc tgcggacaca
      361 gccacatatt tctgtgcacg aagaattagg ggcggttggc cgtattttga cttctggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005507             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14165:16037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005507
VERSION     KCXD01005507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14165:16037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63989.1"
                     /translation="CAAGHSGTWIHWYFDLW"
     D_segment       427..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          145 c          136 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagcttcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cgttgatcct gcatatggtg aatttacacc
      301 cggagagaag ttccagggca gagtaacaat gaccgaggac acgtctatag acacagccta
      361 catggaactg agcagcctga actctgagga cacggccgtc tattactgtg cagccgggca
      421 cagcggcacc tggatccact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005508             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10523:16669
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005508
VERSION     KCXD01005508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10523:16669"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..462
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63990.1"
                     /translation="CARYEDDSGYYYFDSW"
     D_segment       406..418
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>466
                     /gene="IGHG"
BASE COUNT           89 a          133 c          129 g          115 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacttgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc atctgcgctg tctctggtgc
      181 ctccatcacc agtagcttct ggagctggat ccgacagccc ccagggaagg gactggagtg
      241 gattggctat atctatggta gtactgggag tagcagttcc aatccctccc tcaagagtcg
      301 agtcaccatt tcaacggaca cgtccaagaa ccagttttcc ctgaaactga gctctgtgac
      361 cgccgcggac accgcctttt atttctgtgc gagatatgaa gatgatagtg gttattacta
      421 ctttgactcc tggggccagg gagtcctggt caccgtctcc tcggcc
//
LOCUS       KCXD01005509             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15994:21055
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005509
VERSION     KCXD01005509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15994:21055"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63991.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          113 c          147 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaagaa atactacgca aattctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caattgaaca acctgaaatt ggacgacacg gccgtctatt
      421 attgtgcgag agatgatctt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005510             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16514:15084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005510
VERSION     KCXD01005510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16514:15084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    14..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        14..374
     V_segment       14..307
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <299..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63992.1"
                     /translation="CTRADIEAAASFDFW"
     D_segment       313..326
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       331..374
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           96 a           99 c          104 g           77 t
ORIGIN      
        1 acatggggac tcccaggtgc agctggtgca gtctggggct gacattaagc agcctggggc
       61 ctcagtgaaa ctctcctgca agacttcggc atatagcttc atgaactact acatgcactg
      121 ggtgagacag gcccctggac aaggcctaga gtggatagga ctgatctccc cttataatgg
      181 ttataaaggg tacgcacaga acttccagga cagagtcacc ataaccacgg acacgtccac
      241 gaccacaggc tacatggagc tgagaagcct gagatatgag gacacaggcg tttattactg
      301 tacgagagca gatatagaag cggctgcctc ctttgacttc tggggccagg gagtcctggt
      361 caccgtctcc tcagcc
//
LOCUS       KCXD01005511             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11665:18498
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005511
VERSION     KCXD01005511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11665:18498"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..506
     V_segment       134..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63993.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       449..456
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          109 a          133 c          153 g          113 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc acctggtgga gtctggagga gacttggtcc agccgggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg gcatgacctg
      241 ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta ttggcggtgg
      301 taggatatac tacgcagact ccgtgaaggg ccgattcacc atctccagag acaactcaga
      361 gaaaacgctc tccctgcaaa tgaacagcct gagacctgag gacacggccg tatattactg
      421 tgcgtcgaac ctacgtggaa acacctacac ttactggcgg tcctttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005512             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15139:17608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005512
VERSION     KCXD01005512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15139:17608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..342
     V_segment       9..281
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <273..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63994.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       291..296
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..342
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           77 a           83 c          103 g           81 t
ORIGIN      
        1 acatgggggg aggaggcttg gttcagccgg gggggtccct gagactctcc tgtgcagcct
       61 ctggattcac cttcagtacc tttggcatgc actgggtccg ccaggctcca gggatggggc
      121 tggagtgggt ggcagttcta tcttccgatg gaaataagat atactacgca gactctttga
      181 aggaccgatt caccatctcc agagacaatt ccaagaacat gctatatctt caaatgaaca
      241 acctgaaatt ggaggacacg gccgtatatt actgtgtgcg agatgtcagg ggaacggggt
      301 ttgactattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005513             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:26250:5905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005513
VERSION     KCXD01005513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:26250:5905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63995.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          140 c          149 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag ttttccggat acaccttcag tgaaatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005514             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11171:13322
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005514
VERSION     KCXD01005514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11171:13322"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63996.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       427..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          139 c          140 g          103 t
ORIGIN      
        1 acatggggga ttcaacaact gcatccaacc tcaagagaag cccctgagag cacagtttct
       61 caccatggac ttgacctgga agatcctcct cttggtgaca gcagccacag gtgcccactc
      121 ccaggtgcaa ctggtgcagt ctgggggtga gattaagcag cctggggcct cagtgaagct
      181 ctcctgtcag gcttctggat attccctcac tcactacttc atgcactggg tgagacaggc
      241 ccctggacag ggccttgagt ggataggact gatcacccct cacaatgatc ataaagtcta
      301 cgcacagaac ttccagggca gagtcaccat aactacggac acgtccacga gcacagtgtc
      361 catggagctg agcagcctga gatccgaaga cacagccgta tactactgtg cgagaggggg
      421 ggacatagaa tattgtactg gtagtggttg tggggagctt gactcctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005515             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18980:3839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005515
VERSION     KCXD01005515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18980:3839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63997.1"
                     /translation="CARRPWDSDAFDFW"
     D_segment       442..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>503
                     /gene="IGHG"
BASE COUNT          115 a          118 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtccggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag cctccaggga aggggctgca gtgggtggca gttatatcgt
      301 acgatgaaga taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgaggagg ccctgggatt cagatgcttt tgatttctgg ggccaagggc
      481 tcagggtcac cgtctcttta gcc
//
LOCUS       KCXD01005516             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13905:3476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005516
VERSION     KCXD01005516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13905:3476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..485
     V_segment       95..388
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63998.1"
                     /translation="CARYFNYEDDYGYSNTGGTDAFDFW"
     D_segment       396..419
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           95 a          137 c          137 g          118 t
ORIGIN      
        1 acatgggggg agagtcatgg acctcctgtg caagaacatg aagcacctgt ggttcttcct
       61 tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg agtcgggccc
      121 aggactggtg aagccttcgg agaccctgtc cctcacctgc ggtgtctctg gtggctccat
      181 cagcaatagc ttctggagct ggatccgcca gcccccaggg acggggctgg agtggattgg
      241 ctatatcttt ggtggtactg ggagcaccaa ctacaatccc tccctcaaga gtcgagtcac
      301 catttcaaca gacacgtcca agaaccagtt ttccctgagg ttgacctctg tgaccgccgc
      361 ggacaccgcc gtgtattact gtgcgagata tttcaattac gaggatgatt acggttactc
      421 taacaccggt ggtactgatg cttttgattt ctggggccaa ggtctcaggg tcaccgtctc
      481 ttcagcc
//
LOCUS       KCXD01005517             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16445:8527
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005517
VERSION     KCXD01005517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16445:8527"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX63999.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       433..438
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          148 c          139 g           91 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgcccg
      121 ctctgaggtc cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattc tccacgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgcatatg gtgaaatgac
      301 acacgcagaa aacttccagg gcagactcac catgaccgag gacacgtcta cagacacggc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattatt gtgcgagatc
      421 atccagcggt acgtggctat actggtactt cgatacctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005518             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5256:16813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005518
VERSION     KCXD01005518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5256:16813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..493
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64000.1"
                     /translation="CAAGLGDYLVLTEYLEFW"
     D_segment       429..434
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          116 a          139 c          140 g          102 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actgtgaggt ccagctggtg cagtctgggg ctgaagtgaa gaggcctggg gcctcagtta
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaaat atccatgcac tgggtgcgac
      241 aggcccctgg aaaaggactt gagtggatgg gaagtgttga tcctgtttat agtgaagaaa
      301 tactcgcaga taatttccac gacagagtca ccatgaccga ggacacgtct acaggcacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtatatttt tgtgcggcgg
      421 gccttgggga ctatctagtg cttactgaat acctcgaatt ctggggccag ggcgccctgg
      481 tcatcgtctc ctccgcc
//
LOCUS       KCXD01005519             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11628:15213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005519
VERSION     KCXD01005519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11628:15213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..486
     V_segment       112..419
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64001.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       426..435
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>492
                     /gene="IGHG"
BASE COUNT           86 a          147 c          143 g          116 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcac
      121 ctgcaggagt cgggcccagg actgctgaag ccttcggaga ccctgtctgt cacctgcgct
      181 gtctctggtg gctctatcag cagtaccaac tggagctgga tccgccaggc cccagggaag
      241 ggactggagt ggattgggtg tatctttggt ggtggtttct ttggtggtgg aagtcacacc
      301 tcctacagcc cctccctcaa gagtcgagtc accctatcag tagacgcgtc caagacccag
      361 ctctccctga ggctgacgtc tgtgaccgcc gcggacacgg ccgtgtattt ctgtgcgagc
      421 gctgatagtg gttatcctcc ctacttcttt gacatctggg gccagggagt cctggtcacc
      481 gtctccccag cc
//
LOCUS       KCXD01005520             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12361:17771
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005520
VERSION     KCXD01005520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12361:17771"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64002.1"
                     /translation="CARWSAANFDYW"
     D_segment       403..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           88 a          138 c          135 g           97 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgggcaa gaacatgaag catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcaa ctgcaggagt
      121 cgggcccagg actggtgaag ccctcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccaccaa cagtggttat ggctggagct gggtccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtgtctctat gatagtagtg ggaacacgta ctacaacccc tccctcaaga
      301 gtcgcgtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaac ctgaggtcta
      361 tgaccgccgc ggacacggcc gtctattact gtgcgagatg gtcggcagcc aactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005521             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:12856:5239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005521
VERSION     KCXD01005521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:12856:5239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..438
     V_segment       135..361
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64003.1"
                     /translation="CTRGIDNYHFTNTDFDYW"
     D_segment       373..380
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT          105 a          101 c          117 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtgaat tcaccttcag ttcctatgac atgcactggg
      181 ttcgccaggc tccagggaag ggtctggagt gggtttccgg tattaacatt ggcggtgaca
      241 catactaccc agactctgtg aagggtcgat tcactatctc cagagacaat gccaagaact
      301 ccttgtatct tcaaatgaac agcctgagag ttgaggacac tgctgtgtat ttttgtacaa
      361 gggggataga taactaccac tttactaata cggactttga ctactggggc cagggagtcc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005522             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20452:12538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005522
VERSION     KCXD01005522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20452:12538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64004.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005523             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:25318:4422
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005523
VERSION     KCXD01005523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:25318:4422"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64005.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          117 c          153 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggttcg
      181 ccctgggggg tccctgagac tctcctgtgc agcctctgga tttaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttttgtcgtc
      301 tgatggaggt tacaaatacc acgcagactc taagaaggac cgattcacca tctccagaga
      361 caattccaga aacatcctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagggg aatacagtaa ctctattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01005524             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14176:10489
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005524
VERSION     KCXD01005524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14176:10489"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64006.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          121 a          142 c          126 g           99 t
ORIGIN      
        1 acatggggaa acacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga accaccttca ccgaattatc cctgcactgg gttcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gttttaatcc tatatatggt gaaattttac
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta cccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01005525             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7224:14813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005525
VERSION     KCXD01005525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7224:14813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64007.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          138 c          128 g          108 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggacaggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat caccagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtttattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005526             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11903:15766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005526
VERSION     KCXD01005526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11903:15766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..499
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64008.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       425..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          140 c          140 g          109 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctgatgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacaccttc agcatctttg ccatcaattg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gggatcatcc ctcttgttgg gataacaaac
      301 tacgtgcaga agttccaggg cagagtcacc attaccgcgg acacgtccac aagtatagcc
      361 tacatggagc tgagcggcct aagatctgag gacacggccg tgtattactg ttcgagaggg
      421 tcaaattacg aggatgcttc cgattacttt tccgcctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005527             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16777:14323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005527
VERSION     KCXD01005527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16777:14323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..396
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64009.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       402..416
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          137 c          127 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag aaccggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtga
      181 ctctatcagc agtagtcact ggtggagctg gatccgccag cccccaggga aaggcctgga
      241 gtggattggc tatatcagtg gtagtggtga taacacctac tacaacccct ccctcaagaa
      301 tcgagtcacc ttttcaacag tcacgtccaa gaaccagttc tcccttaagc tgagctctgt
      361 gaccgccgcg gacacggcca tgtattactg ttcgagggtg cgtggataca actacatttt
      421 atttgactcc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005528             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10019:7266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005528
VERSION     KCXD01005528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10019:7266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64010.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          112 c          150 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaaacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcctatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005529             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19522:12435
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005529
VERSION     KCXD01005529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19522:12435"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64011.1"
                     /translation="CARGQYSWKGVVVDFW"
     D_segment       420..427
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..468
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          130 c          138 g          105 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctgctggtg gcagctccca gatgggtcct gtcccaggtg cagttgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat caacagtgac tactggacct ggatccgcca ggccccaggg aagggactgg
      241 agtggattgg acgtatctat ggtagaagtg ggagcaccga ctacaatccc tccctccaga
      301 gtcgagtcac catttcaata gacacgtcca agaaccagtt ctccctgaag ctgagttctg
      361 tgaccgtcgc ggacacggcc gtatactact gtgcgagagg ccagtatagt tggaaaggtg
      421 tcgtggtaga tttctggggc caaggcctca gggtctccgt ctcttcagcc
//
LOCUS       KCXD01005530             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5994:11663
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005530
VERSION     KCXD01005530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5994:11663"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64012.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          114 c          154 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 cattcactgg gtccgccaga ctccggggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagacatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtgt attttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgcgagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005531             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17445:16691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005531
VERSION     KCXD01005531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17445:16691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64013.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       435..445
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          120 a          146 c          141 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctccccaac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgtggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc gaggtttcca aatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg acttgttgat cctgtaaatg gtgaactaat
      301 acacgcagac aagttccagg gcagagtcac catgaccgaa gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgacatctga ggacacggcc atctactact gtgcgacagg
      421 gaggatcggt accagtggct ggtccaacct cttcaatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01005532             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17055:16119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005532
VERSION     KCXD01005532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17055:16119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64014.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          143 c          145 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgggtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005533             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20364:3819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005533
VERSION     KCXD01005533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20364:3819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..453
     V_segment       93..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64015.1"
                     /translation="CARTSGGWSPYFDFW"
     D_segment       389..404
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           89 a          138 c          130 g           98 t
ORIGIN      
        1 acatggggag agtcacggac atcctgtgca agaacatgaa gcacctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt gactccatca
      181 gcagtaccta ttggagctgg atccgccagc ccccagggaa gggactggag tggattggac
      241 gtatctctgg tggtggtggg aacaccgact acaacccctc cctcaagagt caagtcacca
      301 tttcaagaga cacgtccagg aaccagttct ccctgcagct gaattatgtg accgccgcgg
      361 acacggccgt atattactgt gcgagaacta gcggtggctg gtccccctac tttgactttt
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005534             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13842:5723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005534
VERSION     KCXD01005534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13842:5723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64016.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       431..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          139 c          150 g           98 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagac cggggctgcg gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctatgtca tcaattgggt gcgccaggcc
      241 cctggacaag ggctagagtg gatgggaggg atcatccctc ttgttggtac aacaaactac
      301 gcacagaggt tccagggcag agtcacgatt attgcggaca cgtccacaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcccc
      421 cctactgaag ggggtgatta ttctgggggg gctttgagcc gatggggcca gggagtccag
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005535             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21143:20434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005535
VERSION     KCXD01005535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21143:20434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..425
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64017.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          102 a          124 c          154 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgaagcctc cgggttcacc ttcagtgacc actgcataca
      241 ctgggtccgc caggcttcag ggaaggggct ggagtgggtc tcaggtatta cttatactgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacac
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctattt
      421 ctgtgtggca ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcgc
      481 cgtctcctca gcc
//
LOCUS       KCXD01005536             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17930:17948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005536
VERSION     KCXD01005536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17930:17948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64018.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          120 c          150 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggt cgaggctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005537             417 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20165:17581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005537
VERSION     KCXD01005537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 417)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 417)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20165:17581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    61..415
                     /note="immunoglobulin heavy chain variable region"
     V_region        61..415
     V_segment       61..354
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>384
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64019.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       357..362
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       373..415
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        416..>417
                     /gene="IGHG"
BASE COUNT           88 a           90 c          133 g          106 t
ORIGIN      
        1 acatgggagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt
       61 gaggtgcagc tggtggagtc tggaggagac ttggttcagc cgggggggtc cctgagactc
      121 tcctgtggag cctctggatt caccttcagt acttttggca tgcactgggt ccgccaggct
      181 ccagggaagg ggctggagtg ggtggcagtt acatcgtctg atgaaagtaa taaatactac
      241 gcagactctg tgaaggcccg attcaccgtc tccagagaca attccaagaa catgttatat
      301 cttcaaatgg acaacctgaa attggaagac acggccgtgt attactgcgc gagagatgtc
      361 tgggggaggg gatttgacta ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005538             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:9922:9685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005538
VERSION     KCXD01005538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:9922:9685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64020.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       434..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          117 c          150 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcatctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcatgc
      241 actgggtccg ccaggctcca ggaaaggggc tggactgggt ggcagttatg tcgtctgatg
      301 gaaataacaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctctatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcttt ggcggggggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005539             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21508:5027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005539
VERSION     KCXD01005539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21508:5027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..481
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64021.1"
                     /translation="CARWGSEDDNVYLDLYFDSW"
     D_segment       424..429
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           98 a          138 c          133 g          114 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcatg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc ttctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tcagcagtga cttctggaac tggatccgcc agtccccagg gaagggactg
      241 gaatggattg ggtatatcta tggtggaact gggagcacca gctacaatcc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccagt tttccctgaa gctgagctct
      361 gtgaccgccg cggacaccgc cgtttattac tgtgcgagat ggggttccga agatgataac
      421 gtttacttag atctttactt tgactcctgg ggccagggac tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01005540             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11379:14250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005540
VERSION     KCXD01005540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11379:14250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64022.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       447..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          115 a          124 c          146 g          129 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcagtg actatgccct
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg attggctata ttagaagcca
      301 atataacaat ttcgcgacag aatacgcccc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacgc tatttctgca aatgagtagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgcaccaccc attttggtgg taattattac ttggactact ttgtctactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005541             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:23696:7132
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005541
VERSION     KCXD01005541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:23696:7132"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..468
     V_segment       96..386
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <381..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64023.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       411..418
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          101 a          120 c          143 g          106 t
ORIGIN      
        1 acatgggggt gatcagcaca gaacacagag gactcaccat ggagtctggg ctgagctggg
       61 ttttccttgt tgctatgttc agaggtgtcc agtgtgaggt gcagctggtg gagtctggag
      121 gagacttggt ccagccgggg gggtccctga gactctcctg tgcagcctct ggattcacct
      181 tcagtagcta tggcatgacc tgggtccgcc aggctccagg gaaggggctg gagtgggtct
      241 catacattag tattggtggt agtaatagat actacgcaga ctccgtgaag ggccgattca
      301 ccatctccag agacaactca gagaaaacgc tctccctgca aatgaacagc ctgagacctg
      361 aggacacggc cgtgtattac tgtgcgtcga acctacgtgg aaacacctac acttactggc
      421 ggtcctttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005542             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:11087:14156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005542
VERSION     KCXD01005542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:11087:14156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64024.1"
                     /translation="CAIGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          143 c          141 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctgggacc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt atatttctgt gcgatagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005543             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10577:17550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005543
VERSION     KCXD01005543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10577:17550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64025.1"
                     /translation="CTRSPITAAGVFDFW"
     D_segment       425..434
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          119 a          136 c          126 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtgcagtc tgggggtgag attaagcagc ctggggcctc aatgaagctc
      181 tcctgcaagg cttctggata taccttcact gactattaca tacactgggt gagacaggcc
      241 cctggacaag gccttgactg ggtaggactg ttctcccctt acaatgatta caaagactac
      301 gctcagaact tccgggacag agtcaccata actgtggaca tgtccacgag cacaggctac
      361 atggaactga gcagcctgag atctgaggac acagccgtgt attactgtac gagaagcccc
      421 ataacagcgg ctggagtttt tgacttctgg ggccagggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01005544             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:24401:15502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005544
VERSION     KCXD01005544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:24401:15502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..496
     V_segment       139..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64026.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       442..447
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          104 a          116 c          162 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagttg gtggagtctg ggggcggctt ggcacagcct
      181 ggggggtccc tgagactctc ctgttcagcc tctggattca ccttcagtag gcactggatg
      241 aactgggtcc gccaggctcc aggaaagggg ctagagtggg tctccggtat taatagtggt
      301 ggggacacta catactacgc agactccgtg aagggccgat tcaccatgtc cagagacaat
      361 tcaaagaaca ctctctccct gcaaatgaac agcctgagag cggaggacac ggccgtgtat
      421 tattgtgtgc aaggggaaat ttttggagtg ggtttggatt tctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005545             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20079:21413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005545
VERSION     KCXD01005545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20079:21413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..319
     V_segment       8..240
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <232..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64027.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       255..260
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           58 a           91 c           98 g           74 t
ORIGIN      
        1 acatggggcg ctgtctctgg tggccccatc agcggtggtt atggctggag ctggatccgc
       61 caggccccag ggaagggact ggagtggatt ggttttatct atggtactgg tggtagcacc
      121 tactacacac cctccctcaa gagtcgactc accatttcag cggacacgtc caagaaccag
      181 ttctccctgc atctgacctc tgtaaccgcc gcggacacgg ccgtgtatta ctgtgcgaga
      241 gtttcgggca ggtgggaact ttttgagcct gggtcagagg acttctgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005546             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16292:15295
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005546
VERSION     KCXD01005546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16292:15295"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64028.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          141 c          149 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgaaatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgat tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005547             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24535:11885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005547
VERSION     KCXD01005547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24535:11885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64029.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          130 c          154 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcag
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc aatacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattagta
      301 gtggtggtag cacatactac gtagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcgaatga acagcctgag agtggaggac acggccgtgt
      421 attactgtgc gaaaggaggt agcagctctt tctactggta tttcgatatc cggggccctg
      481 gcaccccagt caccatctcc tcagcc
//
LOCUS       KCXD01005548             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17124:3430
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005548
VERSION     KCXD01005548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17124:3430"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..490
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64030.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          116 a          112 c          144 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cggtgtgagg tacaactggt ggagtctgga ggaggcttgg ttcaacctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagaaatt ttggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt cgtctgatgg
      301 aagtaacaaa tactacgcca actctgtgaa gagccgattc accatttcca gagacaattc
      361 caagagcata ctatatcttc aaatgaacaa cttgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gatgatattg ggaccggttt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca acc
//
LOCUS       KCXD01005549             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:21842:19446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005549
VERSION     KCXD01005549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:21842:19446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..338
     V_segment       8..271
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64031.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       277..284
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..338
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>344
                     /gene="IGHG"
BASE COUNT           62 a          102 c           99 g           81 t
ORIGIN      
        1 acatggggga gaccctgtct gtcacctgcg ctgtctctgg tggctctatc agcagtacca
       61 actggagctg gatccgccag gccccaggga agggactgga gtggattggg tgtatctttg
      121 gtggtggtat ctttggtggt ggaagtaaca cctactacag cccctccctc aagagtcgag
      181 tcaccctgtc agtagacgcg tccaagaccc agctctccct gaaactgacg tctgtaaccg
      241 ccgcggacac ggccgtgtat ttctgtgcga gcgctgatag cggttatcct ccctacttct
      301 ttgacatctg gggccaggga gtcctggtca ccgtctcccc agcc
//
LOCUS       KCXD01005550             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20183:15179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005550
VERSION     KCXD01005550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20183:15179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..493
     V_segment       136..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64032.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       439..444
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          103 a          115 c          159 g          118 t
ORIGIN      
        1 acatggggga gaggagccca gccctcgaag tccacagtgt tccattcggt gatcagcact
       61 gaacacagag gactcaccat ggagtctggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagttggtg gagtctgggg gcggcttggc acagcctggg
      181 gggtccctga gactctcctg ttcagcctct gggttcacct tcagtaggca ctggatgaac
      241 tgggtccgcc aggctccagg aaaggggcta gagtgggtct ccggtattaa tagtggtggg
      301 gatactacat actacgtaga ctccgtgaag ggccgattca ccatgtccag agacaattca
      361 aagaacactc tctccctgca aatgaacagc ctgagagcgg aggacacggc cgtgtattat
      421 tgtgtgcaag gggaaatttt tggagtgggt ttggatttct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005551             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18868:14361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005551
VERSION     KCXD01005551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18868:14361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64033.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       447..452
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          109 a          113 c          156 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctatgttaa gaggtgtcca gtgtgaggtg cagatggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatcttt
      241 ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttca
      301 tatgatgaaa ttacgaaata ctacgcagac tctgcgaagg accgattcac catctccaga
      361 gacaattcca agaatgtggt atatcttcaa atgaacagcc tgaaattgga ggacacggcc
      421 gtgtatttct gtgcgagagg ggattttggt aatggcgtcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctctgc c
//
LOCUS       KCXD01005552             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21029:10634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005552
VERSION     KCXD01005552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21029:10634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64034.1"
                     /translation="CARYDDDDYGYYYLDYW"
     D_segment       404..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          135 c          131 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 ctccatcagc aatagttact ggttctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggctat atctatggtt ctactgggag caccagctac aacccctccc tcaagagtcg
      301 agtcagcatt tcaacagaca cgtccgagga ccagttctcc ctgaagttga gttctgtgac
      361 cgccacggac accgccgtgt attattgtgc gagatatgac gacgatgatt acggttacta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005553             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:19297:6361
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005553
VERSION     KCXD01005553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:19297:6361"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64035.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          115 a          143 c          132 g           91 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtaga
      301 ctacacacag aagtgccgag acagagtcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tttcctcagc
      481 c
//
LOCUS       KCXD01005554             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12959:18429
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005554
VERSION     KCXD01005554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12959:18429"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64036.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          134 c          130 g          109 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agtcttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tgactccatc agcaatagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tgctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005555             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9300:9293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005555
VERSION     KCXD01005555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9300:9293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64037.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          140 c          134 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagtct gagatctgag gacacggccg tgtattattg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005556             389 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:25467:6947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005556
VERSION     KCXD01005556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:25467:6947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..387
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..387
     V_segment       24..317
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>356
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64038.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       331..336
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       343..387
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        388..>389
                     /gene="IGHG"
BASE COUNT           82 a           95 c          124 g           88 t
ORIGIN      
        1 acatggggaa gggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
       61 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      121 acatgagttg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattgccg
      181 ctgatgggga tagcacatac tatgcagact ccatgaaggc cagattcact atctccagag
      241 agaacgccaa gaacacactg catcttcaaa tggacagcct gagagcagag gacacggctg
      301 tctattactg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gtctggggcc
      361 cgggagtcct gatcaccgtc tcctcagcc
//
LOCUS       KCXD01005557             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:12923:8442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005557
VERSION     KCXD01005557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:12923:8442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..523
     V_segment       145..444
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64039.1"
                     /translation="CAREAYSWNNLYFYGLDSW"
     D_segment       451..464
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..523
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          118 a          120 c          162 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga agagaccccg cctgggattc ccaggagttt ccacttggtg
       61 atcagcactg aacacaaacc accagccatg gagtttgggc tgagctgggt tttccttgtt
      121 gctatttgga aaggtgtcca gtgtgaggtg caactggtgg aatccggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgattat
      241 ggtatggact gggtccgcca ggctccagga aaggggctgg agtgggtagg tttcattaga
      301 agcaaagctt atggtgggac agaagaatac tccgcgtctg tgaaaggcag attcaccatc
      361 tccagagatg attcaaagaa cacggcgtat ctgcaaatga gcagcctgaa aaccgaggac
      421 acggccgtgt atttctgtgc tagagaggcg tatagctgga acaatctata tttctatggt
      481 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005558             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13205:21382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005558
VERSION     KCXD01005558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13205:21382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64040.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       400..406
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          137 c          146 g           98 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc aacttcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttttcggtg gtcgcaatgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaccag acacgtccaa gaaccagttc tccctgaggc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagggag gggatatcag cggcgggggt
      421 cgactactgg ggccagggag ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005559             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:7875:14577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005559
VERSION     KCXD01005559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:7875:14577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..447
     V_segment       93..389
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64041.1"
                     /translation="CARWSAANFDLW"
     D_segment       394..400
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           90 a          132 c          132 g           95 t
ORIGIN      
        1 acatggggag agtcacggac ctcctgggca agaacatgag gcatctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggg ggctccatca
      181 acagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg gagtggattg
      241 ggtgtatcta tgatagtagt ggaaacacct actacaaccc ctccctcaag agtcgagtca
      301 ccatttcaaa agacacgtcc aagaaccagt tctccctgaa tctgaggtct atgaccgccg
      361 cggacacggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac ctctggggcc
      421 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005560             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:16625:2530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005560
VERSION     KCXD01005560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:16625:2530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..343
     V_segment       8..274
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <266..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64042.1"
                     /translation="CARDEDSYAYYYYFDHW"
     D_segment       286..301
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..343
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>349
                     /gene="IGHG"
BASE COUNT           71 a          103 c          101 g           74 t
ORIGIN      
        1 acatggggga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
       61 ctccatcagc aataactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      121 gattggacgt atccatggta gtggggggaa caccgactac aacccctccc tcaagagtcg
      181 agtcaccttt gcaagagaca ggtccaagaa ccagttctcc ctggagctga gctctgtgac
      241 cgcggcggac tcggccgtct attattgtgc gagagacgag gattcttacg cttactatta
      301 ctactttgac cactggggcc agggagtcct ggtcaccgtc tccccagcc
//
LOCUS       KCXD01005561             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19956:18882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005561
VERSION     KCXD01005561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19956:18882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64043.1"
                     /translation="CARVDYSGNYYFHRFDVW"
     D_segment       404..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           98 a          141 c          130 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agttacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgaa acttcagcag
      121 tggggcgaag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggtgacta ctactggagc tggatccgcc agccccccgg gaaggggctg
      241 gagtggattg gatatatcta tgctgatagt gcgaccacca actacaaccc ctccctcaac
      301 aatcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag tggactatag tggtaattat
      421 tacttccacc gcttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005562             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12966:3212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005562
VERSION     KCXD01005562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12966:3212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64044.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       434..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          134 c          149 g          107 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtggagtc cggggctgag gtgaagaagc ctggggcctc agcgaagctc
      181 tcctgcaagg ccgctggata cattttcagt acctctgcca tcagttggct gcgacaggcc
      241 cctggacaag ggcttgagtg gatggggggg attatgcctc ttgttggtag aacaaactac
      301 gcacagaggt tccagggcag agtcacgatt accgcggaca cgtccacaag gacagccaac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc gagcggtggt
      421 ttccaggatg agaacggtta ctattttcca gactattttg acttttgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005563             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:23654:17937
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005563
VERSION     KCXD01005563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:23654:17937"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..254
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <248..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64045.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       263..274
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..326
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           69 a           93 c           95 g           71 t
ORIGIN      
        1 acatgggggg ggatccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
       61 tgctatacac tgggtccgcc aggctcccgg gaaggggctg gagtgggtct cagccattag
      121 tagtggtggt agcacatact acgcagactc catgaagggc cgagccacca tctccagaga
      181 caactcaaag aacacggtct ccctgcaagt gaacagcctg acttctgagg acacggccgt
      241 gttttactgt gcgagagggg agacagcttc agtttactac gctttggatt cctggggcca
      301 aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01005564             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:23428:6074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005564
VERSION     KCXD01005564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:23428:6074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..475
     V_segment       106..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64046.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       406..417
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          141 c          137 g          104 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctttg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tcagcagtaa ctactgggcc tggatccgcc agcccccagg gaagggactg
      241 gagtggattg gacgtatctc tggtagtggt gggagcaccg tctacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac tgacacgtcc aagaaccagg tctccctgaa agtgacttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgacag ccggatatag cagcagcgaa
      421 agcttctacg gtttggattc ctggggccaa ggggtcgtcg tcatcgtctc ctcagcc
//
LOCUS       KCXD01005565             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14043:9855
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005565
VERSION     KCXD01005565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14043:9855"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64047.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          112 a          144 c          135 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gaatggatgg gaagtgttga tcctctatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggccg tgtattactg tgcgactggc cctagcggca
      421 cctggaacgc ctggtacctc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01005566             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:22224:12583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005566
VERSION     KCXD01005566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:22224:12583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64048.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       414..419
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..468
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           92 a          142 c          131 g          105 t
ORIGIN      
        1 acatgggatg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggggt
      121 cgggcccagg gctggtgaag ccttcggaga ccctgtccct cacctgcgct gtttctggtg
      181 actccatcaa cagtggctac tactggagtt ggatccgcca acccccaggg agggggctgg
      241 agtggattgg gtctatcggt ggtagtagtg gcagcaccta ctacaacccc tccctcaaga
      301 gtcgagtcac cctttcaaaa gacacgtcca ggaaccagtt ctccctgaaa ctgagctctg
      361 tgaccgccgc agacacggcc gtttattact gtgcgagaaa acttccaggt ctccaactaa
      421 ccggtttcga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005567             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23145:11355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005567
VERSION     KCXD01005567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23145:11355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64049.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       400..407
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           84 a          138 c          129 g          112 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc gattacttct ggaactggat ccgccagtcc ccagggaggg ggctggagtg
      241 gattggatat ctctatggtg ctactgggat caccggctac aacccctccc tcaagagtcg
      301 agtcaccttt tcagcagaca cgtccaagaa ccagttttcc ctgaagctga cctctgtgac
      361 cgccgcggac accgccgttt attattgtgc gagatatcag ggtgattcct tgtactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005568             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22372:14677
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005568
VERSION     KCXD01005568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22372:14677"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64050.1"
                     /translation="CAREYCTTTDCAGFFDFW"
     D_segment       419..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          133 c          143 g          106 t
ORIGIN      
        1 catgggggca tcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagcta caggtgtcca
      121 gtcccaggtc cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 gctttcctgc aaggcttctg gattcacctt cgacaactat ggaatcaact gggtgcggca
      241 ggcccctgga caagggcttg agtggatggg agtgaccatc ccccttgttg gtattgtaaa
      301 ttatgcagag aagttccagg gcagagtcac gattaacgcg gacacgtcca caaacacagc
      361 cttcatggag gtgaggagcc tgagatctga ggacacggcc atttatttct gtgcgagaga
      421 atactgtaca actacagatt gcgccggctt ctttgacttc tggggccagg gagccatggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005569             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20264:9575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005569
VERSION     KCXD01005569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20264:9575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64051.1"
                     /translation="CARRPLPYEDDYSYYLGIFDYW"
     D_segment       413..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          100 a          134 c          141 g          115 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgt aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggtgatt atggctggaa ctggatccgc caggccccag ggaagggact
      241 ggagtggatt gggagtattt atggtagtag tggtaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga ggctgagctc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ttgtgcgaga agaccgcttc cctacgagga
      421 tgattacagt tattatttgg ggatctttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01005570             276 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:7355:13553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005570
VERSION     KCXD01005570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 276)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 276)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:7355:13553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..274
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..274
     V_segment       9..207
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <199..>243
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64052.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       214..221
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       229..274
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        275..>276
                     /gene="IGHG"
BASE COUNT           66 a           67 c           83 g           60 t
ORIGIN      
        1 acatgggtct acatgagctg ggtccgtcag gctccaggga aggggctgga gtggatctca
       61 agtattgaca atggtgggac taccgcaatt tatgcagact ccgtgagggg cagattcagc
      121 atctccagag agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag
      181 gacacggctg tctattattg tgcgagagca cgcggggtga tcattacata ctttgactcc
      241 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005571             537 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14351:16957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005571
VERSION     KCXD01005571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 537)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 537)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14351:16957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    181..535
                     /note="immunoglobulin heavy chain variable region"
     V_region        181..535
     V_segment       181..474
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <466..>504
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64053.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       478..490
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       494..535
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        536..>537
                     /gene="IGHG"
BASE COUNT          119 a          129 c          163 g          126 t
ORIGIN      
        1 acatggggcc tctgctgatg aaaaccagcc cagccctgac cctgcagctc tgggagagga
       61 gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca cagaggactc
      121 accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt
      181 gaggtgctgc tggtggagtc tggaggaggc ttggttcagc ctggggggtc cctgagactc
      241 tcctgtgcag tctctggatt caccttcagt agctttggca tgcactgggt ccgccaggct
      301 ccagggaagg ggctggagtg ggtggcagtg acatcgtatg atggaagttg gaagtactac
      361 ggagactctg tgaaggaccg attcaccatc tccagagaca attccaagaa catgctatat
      421 cttcagatga acaacctgaa attggaggac acggccgtat atttctgtgc gagaggggaa
      481 tacagtaact ctattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005572             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12891:8231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005572
VERSION     KCXD01005572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12891:8231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64054.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       422..431
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          119 a          142 c          126 g          101 t
ORIGIN      
        1 acatggggca acacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga accaccttca ccgaattatc cctgcactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gttttaatcc tatttatggt gaaattttac
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg atatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta tccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01005573             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20746:11641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005573
VERSION     KCXD01005573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20746:11641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64055.1"
                     /translation="CARVGEDSGGAEDLDFW"
     D_segment       448..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          116 c          158 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcaggacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgagata caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg aatgggtggc acttatatcg
      301 tatgatggag ataagaaata ctacgcagac tctgtgaagg accgattcac cctctccaga
      361 gacaattccg agaacatcct atatcttcaa atgtacaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgcgagagt tggagaggat agtggtggtg cggaggacct tgacttctgg
      481 ggccaaggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005574             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14203:12999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005574
VERSION     KCXD01005574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14203:12999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64056.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          118 a          143 c          136 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ttctgaggtc cagctggtgc aatctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctttatatg gtgaaatgat
      301 acacacagaa cagttccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggtc gtgtattact gtgcgagtgg
      421 ccctagcggc agctggaacg actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005575             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:7829:8119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005575
VERSION     KCXD01005575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:7829:8119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64057.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          112 c          153 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcattc
      241 actgggtccg ccagactccg gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagac atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtgtatttt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgcg agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005576             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12409:9246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005576
VERSION     KCXD01005576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12409:9246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64058.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          123 c          147 g          106 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagtgtcac cgaattatcg attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aagaaattca
      301 cggagaggac ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagttg agcaacctga gatctgagga cacgggcgtg tattattgtg cgagtgggtt
      421 tagtatctgg ttattttacg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01005577             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20374:10177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005577
VERSION     KCXD01005577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20374:10177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64059.1"
                     /translation="CARGIDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          118 a          115 c          149 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagttggtgg aatctggggg aggattggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactttagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005578             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18048:10818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005578
VERSION     KCXD01005578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18048:10818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64060.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       420..426
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          116 a          138 c          142 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagtccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtac agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aggtgttgat actgtatctg atggaatgat
      301 atacgcagaa aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgcgagagg
      421 tgtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005579             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18586:7274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005579
VERSION     KCXD01005579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18586:7274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64061.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       436..441
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          112 c          150 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac gttcagtaac tatggaatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg agtgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01005580             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:17538:10599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005580
VERSION     KCXD01005580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:17538:10599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..504
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64062.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       450..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>508
                     /gene="IGHG"
BASE COUNT          104 a          127 c          157 g          120 t
ORIGIN      
        1 acatggggga gacaggagcc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtggatctca tccattagga acactggtaa
      301 aatcgtatac tacgctgact ccgtgaaggg ccgattcacc atctccagag acaacgccaa
      361 gaactcgctg tctctgcgaa tgagcagcct gagagccgag gacacggccg tgtattactg
      421 tactagaatt ggcgtcggat ctctggcaac ggctggtgac tattttgacc actggggcca
      481 gggagtcctg gtcaccgtct cctccgcc
//
LOCUS       KCXD01005581             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10828:17867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005581
VERSION     KCXD01005581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10828:17867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64063.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       452..467
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          117 a          117 c          154 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca ctgatatcgt
      301 atgatggaag taaggaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tattttcaac tgcacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagtg gggacatatg atagtggtta ttacaccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005582             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13019:7092
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005582
VERSION     KCXD01005582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13019:7092"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64064.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          117 a          117 c          157 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca cttatatcgt
      301 ttgatggaac taagcaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tgtattactg tgcgagagtt agtgggcata cagagggtac agttgaatac tttgactact
      481 ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005583             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:10211:9945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005583
VERSION     KCXD01005583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:10211:9945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64065.1"
                     /translation="CATGRIGSSGWSNLFTGLESW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          147 c          145 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctggg aaagggcttg agtggatggg agttgttgat cctgtcaatg gtgaagaaat
      301 tcacgcagag aaattccagg gcagagtcac cttgaccgag gacacgtcca cagacacagc
      361 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcggt agcagcggct ggtccaacct cttcaccggt ttggaatcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005584             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14804:20814
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005584
VERSION     KCXD01005584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14804:20814"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64066.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          114 c          152 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtaactctg
      241 gcattcactg ggtccgccag gctccagggg aggggctgga gtgggtgtca gttatatcgt
      301 atgatgaaag taagacatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatggta catcttcaaa tgaacaccct gaatttggag gacacggccg
      421 tatattactg tgtgagagat tcttacggta gaggctttga ccagtggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005585             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24979:16488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005585
VERSION     KCXD01005585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24979:16488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64067.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           91 a          137 c          134 g           99 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctggg caagaacatg aagcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccctcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat caacagtggt tatggctgga gctgggtccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtctc tatgatagta gtgggaacac gtactacaac ccctccctca
      301 agagtcgcgt caccatttca aaagacacgt ccaagaacca gttctccctg aacctgaggt
      361 ctatgaccgc cgcggacacg gccgtctatt actgtgcgag atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005586             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7503:3145
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005586
VERSION     KCXD01005586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7503:3145"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64068.1"
                     /translation="CASGPSGTWNDWYFDIW"
     D_segment       427..439
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          145 c          134 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaactttcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgact ggatgggaag tgttgatcct ctatatggtg aaatgataca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg accagcctga gatctgagga cacggccgtg tattattgtg cgagtggccc
      421 tagcggcacc tggaacgact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005587             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22567:12952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005587
VERSION     KCXD01005587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22567:12952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64069.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       442..454
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          121 c          151 g          122 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtacaactgg tggaatctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cctcagtaac tactggatgt
      241 actgggttcg ccaggcacca gggaaggggc tggagtggat ctcagctatt aacagtgttg
      301 gtgataccac atactatgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctatctatt
      421 actgtgcgag agttccgggc ctagtggtat ttaccggttc gcttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005588             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:23707:10012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005588
VERSION     KCXD01005588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:23707:10012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64070.1"
                     /translation="CVKGDTAAVYYGLDFW"
     D_segment       437..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          102 a          129 c          157 g          118 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc actggcagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcag
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctgttcactg ggtccgccag gctccagaaa aggggctgga gtgggtctca gctgttagta
      301 ccggtggtac cacatactac tcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgttctcc cttcaaatga gcagcctgag agctgaggac acggccgtgt
      421 attactgtgt gaagggggat acagctgcag tctactacgg tttggatttc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01005589             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18486:7006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005589
VERSION     KCXD01005589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18486:7006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..483
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64071.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>487
                     /gene="IGHG"
BASE COUNT          119 a          141 c          132 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcgaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgaatgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccctgac cgaggacacg tctacagaca cagcctacat
      361 ggaactgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgattt ctggggccct ggcaccccaa tcaccatctc
      481 ctccgcc
//
LOCUS       KCXD01005590             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20587:5002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005590
VERSION     KCXD01005590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20587:5002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64072.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          113 c          155 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcacgatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tcgggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaaca aagaaatact acgcagactc tctgaagggc cgcttcatca tctccagaga
      361 caattccaag aatatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggtgtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005591             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16538:15134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005591
VERSION     KCXD01005591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16538:15134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64073.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       413..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          107 a          151 c          132 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcccggg gcctcagtga
      181 aggtctcctg caaggtctcc ggaaacacct tcaccgaatt gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcccgcatat ggtgaaatga
      301 cgttccaggg cagagtcatc atgaccgagg acacgtctac agacacagcc tacatggagc
      361 tgaccagcct gacatctgac gacacggccg tctattactg tgcggttggc cctagcggca
      421 cttggaacca ctggcccttc gatatctggg gccctgtcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01005592             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11713:4190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005592
VERSION     KCXD01005592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11713:4190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..467
     V_segment       89..382
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64074.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       386..405
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..467
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          129 c          143 g          101 t
ORIGIN      
        1 acatggggcc ctgggaacac agctcatcac catggacttg acctggaggc tcctctttgt
       61 ggtggcagca gctacaggtg cccagtctca ggtccagctg gtgcagtccg gggctgagat
      121 ggagaagcct ggggcctcag tgaagctctc ctgtaaggct tctggataca ccttcagcat
      181 ctatgtcatc agttgggtgc gacaggcccc tggacaaggg cttgagtgga tgggaggcat
      241 cttccctctt gttggtacaa caaactacgc acagaagttc cagggcagag tcacgattac
      301 cgcggacacg gccacaagca cagcctacat ggacctgagc agcctgggat ctggggacac
      361 ggccgtgtat tattgtgcga gaggctactg tactggtagt ggttgtaacc ttacattcaa
      421 ccggctcgat gtctggggcc cgggagtccc ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005593             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10940:7788
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005593
VERSION     KCXD01005593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10940:7788"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64075.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          114 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005594             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20857:18864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005594
VERSION     KCXD01005594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20857:18864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64076.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          119 c          150 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtgt atcttcaaat gaacaacctg acatttgagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgat tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005595             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23528:16613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005595
VERSION     KCXD01005595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23528:16613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64077.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       407..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          131 c          139 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctccggaga ccctgtccct cacctgcgct gtctctggtg
      181 ggtctatcag aagtagttac tgcagctgga tccgccagac cccagggaag ggactggagt
      241 ggattgggta tatctatggg agtgatagta gtaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagtgctc cctgaagttg agcgctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagttcggg tatagaagtg gttgcctaca
      421 gcattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005596             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21389:20471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005596
VERSION     KCXD01005596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21389:20471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64078.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..448
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          154 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 gccctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttttgtcgt
      301 ctgatggagg ttacaaaaac cacgcagagt ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagca attccattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcggcc
//
LOCUS       KCXD01005597             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:7840:18186
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005597
VERSION     KCXD01005597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:7840:18186"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64079.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           90 a          138 c          132 g          102 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagccg ccatttcaaa agacacgtcc aacaatcaac tctccctgag gttgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005598             297 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10324:22822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005598
VERSION     KCXD01005598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 297)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10324:22822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..295
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..295
     V_segment       8..225
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <217..>264
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64080.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       228..243
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       247..295
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        296..>297
                     /gene="IGHG"
BASE COUNT           65 a           80 c           86 g           66 t
ORIGIN      
        1 acatgggctg gattcacctt cagtacctat gctatgcact gggtccgcca ggctccaggg
       61 aaggggctgg agtgggtctc agccattagt gttggtggta gtacatacta cgcagactcc
      121 gtgaggggcc gattcaccat ctccagagac aactcagaga acacgctctc cctgcacatg
      181 aacagcctga cagctgagga cacggccgtg tattactgtg cgaaagggga tacagctaca
      241 gtttattacg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005599             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18978:6132
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005599
VERSION     KCXD01005599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18978:6132"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64081.1"
                     /translation="CATGTIGSSVWSSLFNGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          117 a          144 c          146 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagctc caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatgcact gggttcgaca
      241 ggcccctgga aaagggcctg agtggatggg ggttgttaat cctgtaaatg gtgaagaaat
      301 acacgcagag aagttccagg ccagagtcac catgaccgag gacacgtcta caggcacagc
      361 ctatatggag ctgagtagtc tgagatctga ggacacggcc atctattact gtgcgacagg
      421 gacgatcggt agcagcgtct ggtccagcct cttcaacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005600             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10088:6130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005600
VERSION     KCXD01005600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10088:6130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64082.1"
                     /translation="CARSPSGNWLYWFFDFW"
     D_segment       421..427
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          146 c          129 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattttcc atccactggc tacgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtttttggtg aaataattca
      301 cgcagagata ttccagaaca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctga gatctgagga cacggccgtg tattactgtg cgcgatcacc
      421 cagcggcaac tggctatact ggttcttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005601             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12368:19552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005601
VERSION     KCXD01005601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12368:19552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64083.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       436..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          119 c          146 g          118 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcactacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat cgtttgatga
      301 aactaaggaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtgtatta
      421 ctgtgtgaga gattcttacg gccgaggctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005602             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11556:16168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005602
VERSION     KCXD01005602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11556:16168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64084.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          115 a          120 c          144 g          131 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga actgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggtggagt ctgggggagg cttggtacat
      181 cctggggcgt ccctgagact ctcctgtgca gcctctgagt tcaccttcag tggctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctagaat gggtatcagg tattaacatt
      301 ggcggtgacc catactaccc agactctgtg aagggtcgat tcaccatctc cagagacaac
      361 gccaagaact ccttgtatct tcaaatgaac aacctgagac ctgaggacac tgctgtgtat
      421 tattgtgtga gggggatgga taactaccac ttcagtaata cggactttga ctattggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005603             413 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10530:8249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005603
VERSION     KCXD01005603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 413)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 413)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10530:8249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..411
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..411
     V_segment       33..340
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <333..>380
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64085.1"
                     /translation="CASADSGFPPYFFDFW"
     D_segment       344..352
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..411
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        412..>413
                     /gene="IGHG"
BASE COUNT           71 a          123 c          120 g           99 t
ORIGIN      
        1 acatgggggc agctcccaga tgggtcctgt cccagctgca gctgcaggag tcgggcccag
       61 gacttgtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt ggctctatca
      121 gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggaa tggattgggt
      181 gtatctttgg tggtggtatc tttggtggtg gtagtaacac ccagtacagc ccctccctca
      241 agagtcgagt caccctttca gtagacgcgt ccaagaacca actctccctg cagctgacgt
      301 ctgtgaccgc cgcggacacg gccatctatt tctgtgcgag cgctgatagt ggttttcctc
      361 cctacttctt tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005604             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13793:7213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005604
VERSION     KCXD01005604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13793:7213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64086.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       439..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          123 c          155 g          119 t
ORIGIN      
        1 acatgggctg agagaggagc cttagccctg gatttcaagg cacttccacc tggggatcag
       61 cactgaacac agaggaccca ccatggagtt gggactgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggaggct tggtccagcc
      181 tggagggtct ctgagactct cctgtgtagc ctctggattc agcttcagaa gttacgacat
      241 gagttgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagtcacac
      301 tggtgaaacc atataccacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtcta
      421 ttactgcact aggaaccgga atactgttat gattgggtgg ttcgatgtct ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005605             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15289:7055
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005605
VERSION     KCXD01005605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15289:7055"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64087.1"
                     /translation="CARLGSSYGIFLRYFDHW"
     D_segment       409..417
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           90 a          137 c          141 g          109 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggcgaa gccttcagag accctgtccc tcacctgcgc tgtctctgga
      181 gtctctatca gcggtggtta tgactggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtatatctc tggtagtagt gggaccacca actacaaccc gtccctcatg
      301 aatcgagtca ccgtgtcaaa agacacgtcc aagaaccagt tctccctgaa agtgagctct
      361 gtgaccgccg cggacacggc cgtctattac tgtgcgaggc tgggtagcag ctacggtatt
      421 tttttgcgct actttgacca ctggggccgg ggagtcgtgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005606             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23092:16693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005606
VERSION     KCXD01005606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23092:16693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..439
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64088.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       442..448
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          114 a          122 c          160 g          121 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattcccagg cgtctccact tggtgatcag
       61 cactgaacac aagagactca ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 tttaaagggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgtagg ctctggattc accttcagtg actatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg gttggctata ttagaagcaa
      301 atcttacaat tacgcggcag aatacgccgc atcggtgaaa ggcaggttca ccgtctccag
      361 agatgattca aagaacacgc tacatctgca aatgagcagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgtgctagag gggatatacc ggctatagag gcctactacg gtttggattc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005607             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11189:11047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005607
VERSION     KCXD01005607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11189:11047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..363
     V_segment       8..288
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64089.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       302..308
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       312..363
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           89 a           92 c          107 g           77 t
ORIGIN      
        1 acatgggggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg aaggtctcct
       61 gcaaggtttc cggatacatc ttaaccgagt tatccataca ctgggtgcga caggcccctg
      121 gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg atagacgcag
      181 agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg
      241 agctgagcag tctgagatct gaggacacgg ccgtgtatta ctgtgcgaca tcatccagcg
      301 gcacctggct atactggtac ttcgatttct ggggccctgg caccccaatc accatctcct
      361 cagcc
//
LOCUS       KCXD01005608             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8709:15327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005608
VERSION     KCXD01005608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8709:15327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64090.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       409..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          108 a          141 c          136 g           90 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtctttctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccctcaccga agtgtccact cactgggtgc gacaggcccc
      241 cggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc cacagacaca gcctacatgg aattgagcag
      361 cctaagatct gaggacacgg ccgtgtatta ctgtgcgatt ggacctaccg gcaggtggaa
      421 cggctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01005609             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16907:4524
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005609
VERSION     KCXD01005609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16907:4524"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..462
     V_segment       114..405
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64091.1"
                     /translation="CARADRGSSIDYW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>468
                     /gene="IGHG"
BASE COUNT          107 a          107 c          139 g          115 t
ORIGIN      
        1 acatggggca cagtgttcca ttcggtgatc agcacagaac acagaagact caccatgaag
       61 tttgggctga gttgggtttt ccttgttgca attttaagag gtgtccagtg tggggtgcag
      121 ctggtggagt ctggaggagg cttggttcag cctggggggt ccctgagact ctcctgtgta
      181 gcctctggat tcaccttcag aacctatggc atgcactggg tccgccaggc cccagggaag
      241 gggctggagt gggtggcggt tatatcatat gatgatgaca agaaatatta cgcagactct
      301 gtgaaggacc gattcaccat ctccagagac aattccaaga acattcttta tcttcaaatg
      361 aacaacctga aattggagga cacggccgtg ttttattgtg cgagagcgga tcgcggcagt
      421 tcaattgact actggggcca gggagtcctg gtcaccgtct ccccagcc
//
LOCUS       KCXD01005610             378 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9475:19367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005610
VERSION     KCXD01005610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 378)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 378)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9475:19367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    22..376
                     /note="immunoglobulin heavy chain variable region"
     V_region        22..376
     V_segment       22..315
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <307..>345
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64092.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       318..330
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       342..376
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        377..>378
                     /gene="IGHG"
BASE COUNT           87 a           88 c          117 g           86 t
ORIGIN      
        1 acatggggag gtgtccagtg tgaagtccaa ctggtggagt ctggaggagg cttggttcag
       61 ccgggggggt ccctgcgact ctcctgtgca gcctctggat tcaccttcac tacttttggc
      121 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgaat
      181 gatggaagta agaaatatta cgcagactct gtgaaggacc gattcacctt gtccagagac
      241 aataccaaga acatgctata tattcaaatg aacaacctga aattggagga cacggccatg
      301 tattactgtg tgagagatga ctacggtagc ggcctcgggt cctggggcca gggagtcctg
      361 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005611             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17789:15188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005611
VERSION     KCXD01005611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17789:15188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64093.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       444..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          115 a          112 c          153 g          118 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcac ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgaa gcctctggat tcaccttcag tagttatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtat
      301 gatgtaagta agaaatacta cgcagacgct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acaccctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattactgtg ggagagatga taatggggtg cttatcgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005612             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:5922:5454
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005612
VERSION     KCXD01005612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:5922:5454"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64094.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          112 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgacctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005613             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17629:18033
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005613
VERSION     KCXD01005613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17629:18033"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64095.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          144 c          144 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggct tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005614             420 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15400:6657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005614
VERSION     KCXD01005614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 420)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 420)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15400:6657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    64..418
                     /note="immunoglobulin heavy chain variable region"
     V_region        64..418
     V_segment       64..357
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <349..>387
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64096.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       358..363
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       373..418
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        419..>420
                     /gene="IGHG"
BASE COUNT           95 a          115 c          123 g           87 t
ORIGIN      
        1 acatgggggg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
       61 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      121 atctcctgcc aggcttccgg atacacctta accgaccact acctacactg ggtgcgacag
      181 gctcctggaa aaggacttga gtggatggga ggtattcttc ctgagtatgg taaagttgac
      241 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      301 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      361 ggtccctacc attactttga ctactggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005615             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17982:8532
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005615
VERSION     KCXD01005615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17982:8532"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64097.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          139 c          134 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01005616             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24547:15073
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005616
VERSION     KCXD01005616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24547:15073"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64098.1"
                     /translation="CATSSSGTWLYWYFDIR"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          136 g           94 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcga caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat attggtactt cgatatccgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005617             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14270:4498
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005617
VERSION     KCXD01005617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14270:4498"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..476
     V_segment       102..409
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64099.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       415..422
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>482
                     /gene="IGHG"
BASE COUNT           86 a          144 c          140 g          112 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcac ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct gtctctggtg
      181 gctctatcag cagtaccaac tggagctgga tccgccaggc cccagggaag ggactggagt
      241 ggattgggtg tatctttggt ggtggtatct ttggtggtgg aagtaacacc tactacagcc
      301 cctccctcaa gagtcgagtc accctgtcag tagacgcgtc caagacccag ctctccctga
      361 aactgacgtc tgtaaccgcc gcggacacgg ccgtgtattt ctgtgcgagc gctgatagcg
      421 gttatcctcc ctacttcttt gacatctggg gccagggagt cctggtcacc gtctccccag
      481 cc
//
LOCUS       KCXD01005618             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15035:3950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005618
VERSION     KCXD01005618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15035:3950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64100.1"
                     /translation="CARGPVTIFGVLITGLDYW"
     D_segment       426..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          142 c          142 g          103 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatccacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaaggacttg agtggatggg aggtgttgct cctctatatg gtgaaatgat
      301 gcacgcagac aacttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga cgacacggcc gtgtattact gtgcgcgtgg
      421 gcctgttaca atttttggcg tacttattac ggggcttgac tactggggtc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005619             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13886:5650
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005619
VERSION     KCXD01005619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13886:5650"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64101.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       443..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          116 c          152 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgtggctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcggcct
      181 ggggggtccc tgagactctc ctgtgcagtc tctggattca ccttcagtaa ttttggcatc
      241 cactgggtcc gccaggctcc agggaagggc ctggagtggg tggcagttat atcgtctgat
      301 gaaagtaaga aatactatgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaact tggaggacac ggccgtctat
      421 tactgtgcga gggacgcatt tggcagcggc tgtgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005620             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19405:18668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005620
VERSION     KCXD01005620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19405:18668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64102.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       438..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          114 c          150 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggaacccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttatt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt acagcctctg gattcacctt cagtagctat
      241 ggcttacact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tctgatgaaa gtaggaaata ctacgcagac tctctgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattatt gtgcgaggga tgataatggg gtgcttatcg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005621             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15442:6011
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005621
VERSION     KCXD01005621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15442:6011"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64103.1"
                     /translation="CARPRNIGVRYLGYW"
     D_segment       401..406
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           93 a          136 c          138 g           98 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag ggctggtgga gccttcggag accctgtccc tcacctgcgc tgtctctggg
      181 ggctccatca gtggttacta ctggaactgg atccgccaac ctccagggaa ggggctggag
      241 tggattggat atatcggtgg tagtagtggg atcacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt atactattgt gcgagaccaa ggaacatagg ggtgcgatac
      421 ctgggctact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005622             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15285:3760
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005622
VERSION     KCXD01005622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15285:3760"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64104.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          139 c          139 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctggcc ctcacctgcg ctgtctctgg
      181 tggctccatc agtggttact ggtggggctg gatccgccag tccccaggga gggggctgga
      241 atggattgga tttttcggtg gtagtggtgg gaacacctac tacaagtcct ccctccagag
      301 tcgagtcacc atttcagccg acccgtccaa gaaccagttc tccctgatac tgacctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgcggggg aatatagcag cgactggcat
      421 tgactactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005623             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6912:18649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005623
VERSION     KCXD01005623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6912:18649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64105.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          114 c          153 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatcc
      241 actgggtccg ccaggctccg gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaacaaagaa attctacgca ggctctctga aggaccgctt catcatctcc agagacaact
      361 ccaagaacat ggtatatctt caaatgaata gcctgcaatt ggaggacacg gccatatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgacttctg gggccagggt gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005624             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13553:15288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005624
VERSION     KCXD01005624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13553:15288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64106.1"
                     /translation="CANALTGGLDYW"
     D_segment       436..444
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          108 a          122 c          155 g          106 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaga tactggatga
      241 actgggtccg ccaggctcca gagaaggggc tggagtgggt ctcaggtatt aatagtggtg
      301 gggatagcac acactacgca gactccgtga agggtcgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gccttagagc ggaggacacg gccatatatt
      421 actgtgcgaa cgcgttaact ggggggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005625             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18791:11731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005625
VERSION     KCXD01005625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18791:11731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64107.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          140 c          137 g          106 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag
      121 tcccaggtcc gcctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgcg gggcttctgg attcaccctc gacacctatg gtatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtggtcatcc cccttattgg tatcataaac
      301 tacgcaaaga actctcaggg cagactcaca ataaccgcga acacgtccac aaatacagcc
      361 tatttggaac tgagcagtct gagatctgag gacacggcca tctattactg tgcgagagaa
      421 tactgtactt ctagttcttg cgccgggttc cttgactact ggggccaggg agccctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005626             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18162:16790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005626
VERSION     KCXD01005626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18162:16790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64108.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       418..437
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          141 c          146 g          106 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata caccttcagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggctac
      421 tgtactggta gtggttgtaa ccttacattc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01005627             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:26945:12407
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005627
VERSION     KCXD01005627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:26945:12407"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..343
     V_segment       8..282
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <274..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64109.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       292..297
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..343
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           81 a           81 c          104 g           79 t
ORIGIN      
        1 acatgggctg gaggaggctt ggttcagccg ggggggtccc tgagactctc ctgtgcagcc
       61 tctggattca ccttcagttc ctatggcata cactgggtcc gccagtctcc agggaagggg
      121 ctggagtggg tggcagttat atcgtatgat gaaactaaga agtactacgc agactctgtg
      181 agggaccgat tcaccatctc cagagacaat tccaaaaaca tggtatatct tcaaatgaac
      241 aacctgaaat tggaggacac ggccgtatat tactgtgtga gagatgtcag gggaacgggg
      301 tttgacttct ggggccaggg aggcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005628             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20132:19514
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005628
VERSION     KCXD01005628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20132:19514"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64110.1"
                     /translation="CATHGGDSDIWNSLYHGLDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          120 a          148 c          142 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagccac cggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagttaaga agcctggggc ctcagtgatg
      181 gtctcctgcc aggtttccgg atacaccgtc accgaaattc ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgctc ctgaaaaaaa tgagttaata
      301 cacgcagaca agttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtggcct gacatctgag gacacggccg tgtattactg tgcgacccac
      421 ggaggggata gcgacatctg gaactcccta tatcacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005629             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9472:18875
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005629
VERSION     KCXD01005629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9472:18875"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64111.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggcg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005630             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10612:10286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005630
VERSION     KCXD01005630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10612:10286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64112.1"
                     /translation="CATSSSGTWLYWSFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          142 c          134 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacatctta accgaattat ccatacactg ggtgcgacag
      241 gccgctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgaaa
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagtct gagatctgac gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtccttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005631             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13210:14231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005631
VERSION     KCXD01005631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13210:14231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64113.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       441..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          102 a          126 c          155 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca caccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccattg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctaagact ctcctgtgaa gcctccgggt tcaccttcag tgaccactgc
      241 atacactggg tccgccaggc ttcagggaag gggctggagt gggtctcagg tattacttat
      301 actggtgtta ccacatggta cgcagactcc gtgaggggca gattcaccat ctccagagag
      361 aacaccaaga acacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tatttctgtg tggcaggaag gcggcacgtg gaccttgact actggggcca gggagtcctg
      481 gtcgccgtct cctcagcc
//
LOCUS       KCXD01005632             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10024:13004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005632
VERSION     KCXD01005632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10024:13004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..468
     V_segment       108..401
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64114.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       411..418
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           85 a          143 c          140 g          102 t
ORIGIN      
        1 acatgggggg gaaatgctct ctgagagtca cggacatcct gtgcaagaac atgaagcgcc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcagctgc
      121 aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct
      181 ctggtggctc cttcagcggt tactcctgga gctggatccg ccagccccca ggcaagggtc
      241 tggagtggat tggacatgtc agtggtagta gtgggagcac cgactacaac ccctccctca
      301 agagtcgagt caccatttca acagacacgt ccaagcgcca gttctccctg aggctgattt
      361 ctgtgaccgc cgcggacacg gccgtctatc attgtgcgag agtccggggc gtgactatct
      421 attactttga ctactggggc cagggagccc tggtcaccgt cgcctcagcc
//
LOCUS       KCXD01005633             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7012:5030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005633
VERSION     KCXD01005633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7012:5030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..491
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64115.1"
                     /translation="CARGDFGNGVDYW"
     D_segment       441..446
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          108 a          111 c          155 g          121 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatg
      121 ttaagaggtg tccagtgtga ggtgcagatg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtat ctttggcatc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ttcatatgat
      301 gaaattacga aatactacgc agactctgcg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaatg tggtatatct tcaaatgaac agcctgaaat tggaggacac ggccgtgtat
      421 ttctgtgcga gaggggattt tggtaatggc gtcgactact ggggccaggg agtcctggtc
      481 accgtctcct ctgcc
//
LOCUS       KCXD01005634             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:4602:21493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005634
VERSION     KCXD01005634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:4602:21493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..514
     V_segment       145..441
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <433..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64116.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       452..466
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          107 a          124 c          157 g          128 t
ORIGIN      
        1 acatggggga gctctaggag aggagcccag ccctgggatt cccaggtgtt ttcatttgtg
       61 atcagcactg aacacagaag actcatcatg gagtttggcc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gggtgaggtg cagctggtgg agtctggggg cggcttggca
      181 aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgactac
      241 tggatgtact gggttcgcca gacacctgag cgggggctgg agtggctctc agctattgat
      301 agtgctggta ctagtaccac atactatgca gactccgtga agggcagatt caccatctcc
      361 agagagaacg ccaaaaacac actgtatctt cagatggaca gcctgagaac tgaggacacg
      421 gctgtctatt actgtgcgag agttccgggc ctagtggtat ttactggttc gcttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005635             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5803:15178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005635
VERSION     KCXD01005635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5803:15178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64117.1"
                     /translation="CARLEKDDYGYYTMGVNRFDVW"
     D_segment       412..423
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           95 a          139 c          142 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 ggttggacgt atctctggta gtggtgggac caccgactat aacccctccc tcaggagtcg
      301 agtcaccatt tcaacagaca cgtccaaaaa ccagttctcc ctgaaactga gctctgtgac
      361 cgtcgcggac acggccgtgt attactgtgc gagattggag aaggatgatt atggttatta
      421 cactatgggg gtcaaccggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01005636             304 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11675:9685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005636
VERSION     KCXD01005636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 304)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 304)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11675:9685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..302
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..302
     V_segment       8..226
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>271
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64118.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       227..236
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       260..302
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        303..>304
                     /gene="IGHG"
BASE COUNT           74 a           74 c           93 g           63 t
ORIGIN      
        1 acatggggga tacaccttca ccgaattatc catgcactgg gtgcgacagg cccctggaaa
       61 agggcttgag tgggtgggag gtgttgatcc tctatatggt gaaaaaagac acgcagagaa
      121 gttccagggc agagtctcca tgaccgagga cacgtctaca aacacagcct acatggagct
      181 gagcagcctg agatctgagg acacggccgt gtactattgt gcgagaggat attgtagcgg
      241 tagtcactgc tcgtccggat ttgactactg gggccaggga gtcctggtca ccgtctcctc
      301 agcc
//
LOCUS       KCXD01005637             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13625:13919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005637
VERSION     KCXD01005637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13625:13919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64119.1"
                     /translation="CASNSITSGPDYW"
     D_segment       399..405
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          141 c          129 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag gcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cgcctgcagc tgcaggcggc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgg
      181 ctctatcagc ggtaactact ggagctggat ccgccgggcc ccagggaagg gactggagtg
      241 gattggatat atctacggta gtgattttac caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagcagata cgtccaagaa ccagctctcc ctgaacctgg cctctgtgac
      361 cgccgcggac acggccgtct atttctgtgc cagtaatagt ataacatctg gtccagatta
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005638             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21875:4371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005638
VERSION     KCXD01005638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21875:4371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..327
     V_segment       9..260
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64120.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       267..274
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           73 a           83 c           98 g           75 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttatt
       61 tctacatgag ctgggtccgt caggctccag gaaaggggct ggagtggatc tcaagtattg
      121 acaatggtgg gactaccaca aattttgcag actccgtgag gggcaggttc accatctcca
      181 gagagaacgc caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg
      241 ctgtctatta ttgtgcgaga gcgcgcgggg tgatcattac atactttgac tcctggggcc
      301 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005639             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8152:15809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005639
VERSION     KCXD01005639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8152:15809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64121.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       441..449
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          113 c          155 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccacacgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctttttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg aggctctcct gtgcagcctc tggattcacc ttcagtcact atggcgttca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat cgtatgatga
      301 aaataagaaa tactacgcag actctgtgag ggaccgattc accatctcca gagacaattc
      361 caagaccatg gtatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtattt
      421 ctgtgtgaga gatgtcagag gcggtggctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005640             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:26770:8481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005640
VERSION     KCXD01005640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:26770:8481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64122.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       445..449
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          114 c          153 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagtacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatctcatt
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcacat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagatg tcagggggac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005641             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18241:3116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005641
VERSION     KCXD01005641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18241:3116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64123.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          117 c          145 g          131 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggaatctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagttc ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tttccggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtacaaggg ggatagataa ctaccacttt agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005642             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7677:6597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005642
VERSION     KCXD01005642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7677:6597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..259
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64124.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       269..274
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..320
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           79 a           76 c           94 g           73 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagctt
       61 tggcatacac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc
      121 gtatgatgaa actaagaaat actacgcaga ctctgtgagg gaccgattca ccatctccag
      181 agacaattcc aaaaacatgg tatatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtatattac tgtgcgagag atgtcagggg aacggggttt gacttctggg gccagggagt
      301 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005643             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10798:17798
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005643
VERSION     KCXD01005643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10798:17798"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64125.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          113 a          122 c          155 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcaca aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtga agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc aattattact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca agtattaata
      301 gtggtgggga aagcacatac tctgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacacta tatcttcaaa tggacagcct gagaactgag gacacggctg
      421 tctattactg tgtgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005644             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21828:12231
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005644
VERSION     KCXD01005644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21828:12231"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..497
     V_segment       139..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64126.1"
                     /translation="CAKGGSSSFYWYFDLG"
     D_segment       435..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          130 c          148 g          115 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagcactgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct ggcttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggcggctt ggcaaagcct
      181 gggggatccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctatgctatg
      241 cactgggtcc gccaggctcc agggaagggg ctgaaatggg tctcatctat tagtagtggt
      301 ggtctcacat actacgcaga ctccgtgaag ggccgatttg ccatctccag agacaactca
      361 aagaacacgc tctccctgca aatgaacagc ctgagcgctg aggacacggc cgtatattac
      421 tgtgcgaaag gaggtagcag ctctttctat tggtacttcg atctggggcc ctggcacccc
      481 agtgaccatc tcctcagcc
//
LOCUS       KCXD01005645             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:2752:10688
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005645
VERSION     KCXD01005645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:2752:10688"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64127.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       400..414
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          135 c          133 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggcgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atattagtat tagtgggagg accgactaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cagttctccc tgaagttgac ctctgtgacc
      361 gtcgcggaca cggccgtgta ttactgtgcg agatatccat atagtgggag ctacttcagg
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005646             280 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:26456:14174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005646
VERSION     KCXD01005646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 280)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 280)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:26456:14174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..278
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..278
     V_segment       8..205
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <197..>247
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64128.1"
                     /translation="CARVGENTGGAEDFDFW"
     D_segment       213..221
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..278
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        279..>280
                     /gene="IGHG"
BASE COUNT           69 a           63 c           84 g           64 t
ORIGIN      
        1 acatgggggc atgcactggg tccgccaggc tccagggaag gggctggagt gggtgtcact
       61 tatatcgtat gatggaagta agaaatacta cgcagactct gtgaaggacc gattcaccat
      121 ctccagagac aattccgaga acatgctatt tcttcaaatg aacaacctga aattggacga
      181 cacggccgtg tatttctgtg cgagagttgg agagaatact ggtggtgcgg aggactttga
      241 cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005647             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14221:20141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005647
VERSION     KCXD01005647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14221:20141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64129.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       412..416
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           93 a          138 c          132 g          101 t
ORIGIN      
        1 acatggggga aggttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggcgccat cagcagtggt ttctactgga cctggatccg ccaaccccca gggaaggggc
      241 tggagtggat tgggtgtatc ggtggtaata gtggtaccac ctactacaac ccctccctca
      301 agagtcgagc caccatttca aaagacacgt ccaacaatca actctccctg aaggtgagtt
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag agatgaagac ccctccattt
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005648             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17069:4346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005648
VERSION     KCXD01005648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17069:4346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64130.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       434..439
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          148 c          139 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 gctctgaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt ctccacgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgcatat ggtgaaatga
      301 cacacgcaga aaacttccag ggcagactca ccatgaccga ggacacgtct acagacacgg
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtattat tgtgcgagat
      421 catccagcgg tacgtggcta tactggtact tcgatacctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01005649             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9346:4723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005649
VERSION     KCXD01005649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9346:4723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64131.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       428..435
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          110 a          141 c          145 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gcagtgaaga ggcctggggc ctcagttaag
      181 gtctcctgca aggtttccgg atactccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctgtgtatgg tgaagaaata
      301 cacgcagaga atttccagga cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggagc tgagcagcct gagacgtgag gacacggccg tgtatttctg tgcggcgggc
      421 cttggggggt atttagttct tactgaatac ctcgaattct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01005650             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21818:7545
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005650
VERSION     KCXD01005650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21818:7545"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64132.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          147 c          146 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggatggga gttgttgatc ctgtcaatgg tgaagaaata
      301 cacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcgcctg gtccaacctc ttcaccggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005651             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:26629:14740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005651
VERSION     KCXD01005651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:26629:14740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64133.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          116 c          150 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttctt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tatgatgaaa gtaagaaata ctacgcagac tctctgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgcaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgataatggg gtgcttatcg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005652             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10340:18164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005652
VERSION     KCXD01005652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10340:18164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64134.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       437..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          131 c          154 g          113 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcaact ggtggagtct gggggcggct tggcaaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcagta cctatgctat
      241 acactgggtc cgccaggctc ccgggaaggg gctggagtgg gtctcagcca ttagtagtgg
      301 tggtagcaca tactacgcag actccatgaa gggccgagcc accatctcca cagacaactc
      361 aaagaacacg gtctccctgc aagtgaacag cctgacttct gaggacacgg ccgtgtttta
      421 ctgtgcgaga ggggagacag cttcagttta ctacgctttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005653             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18638:9241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005653
VERSION     KCXD01005653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18638:9241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64135.1"
                     /translation="CARDAGYGDTILVVDINMFPHFDYW"
     D_segment       414..437
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          103 a          138 c          137 g          117 t
ORIGIN      
        1 acatggggat cctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtga tgtctctggt
      181 gcctccatca gtagttactg gtggacctgg atccgccagt ccccagggaa gggactggaa
      241 tggattgggg agatcaatgg taatagtggt agtatttact acaacccctc cctcaacagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt atatttctgt gcgagagatg ccggctatgg ggatacgata
      421 ttagtcgtcg atattaatat gttcccccac tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005654             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24991:8592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005654
VERSION     KCXD01005654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24991:8592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64136.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          111 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agtaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttatgtcgt
      301 ctgatggaac taagaaattc tacgcagact ctgtgaaggt ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacagcct gaaatcggag gacacggccg
      421 tgtattattg tggtagagat gataatgggg tgattatcga ctactggggc cagggagtcc
      481 tggtcaccgt cacctcagcc
//
LOCUS       KCXD01005655             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24577:14168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005655
VERSION     KCXD01005655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24577:14168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64137.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          122 c          158 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actcaacaca gaacatacca tggagtatgt gctgagttgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005656             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14742:17627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005656
VERSION     KCXD01005656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14742:17627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    15..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        15..280
     V_segment       15..219
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <211..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64138.1"
                     /translation="CARDLLGLTFDHW"
     D_segment       226..230
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       237..280
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>282
                     /gene="IGHG"
BASE COUNT           65 a           82 c           74 g           61 t
ORIGIN      
        1 acatgggtca gcgacagtta caggtggagc tggatccgcc agcccccagg gaagggactg
       61 gagtggattg gatacatcta tggtcctact acgactacca actacaaccc ctccctcaaa
      121 agtcgagtca ccatttcaaa agacacgtcc aagaatcaga tctccttgag gttgacctct
      181 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atcttctggg tttgaccttt
      241 gaccactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005657             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12123:16187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005657
VERSION     KCXD01005657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12123:16187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64139.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           93 a          138 c          131 g          101 t
ORIGIN      
        1 acatggggaa ggttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggcgccatc agcagtggtt tctactggac ctggatccgc caacccccag ggaaggggct
      241 ggagtggatt gggtgtatcg gtggtaatag tggtaccacc tactacaacc cctccctcaa
      301 gagtcgagcc accatttcaa aagacacgtc caacaatcaa ctctccctga aggtgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005658             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16685:15835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005658
VERSION     KCXD01005658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16685:15835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64140.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       406..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           88 a          139 c          137 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgga agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca cctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatcagtgg gagtagtggg agcaccgact acaagtcctc cctcaacagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaggct gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtcc ggggcgttac tatccactac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005659             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:17040:12545
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005659
VERSION     KCXD01005659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:17040:12545"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64141.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       427..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..494
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          140 c          147 g           97 t
ORIGIN      
        1 acatgggcaa cgcagagtac atggggatca cacaacaacc acatccctcc cctacagaag
       61 ccccagagca cagcacctca ccatggactg gacctggagg atcctcctct tggtggcagc
      121 agctacaggc gcccactctg aggtccttct ggtgcagtct ggggctgagg tgatgcagcc
      181 tggggcctca gtgaaggtct cctgcaaggt ttccggatac accttcaccg atttgtccat
      241 acactgggtg cgacaggccc ctggaaaagg gcttgagtgg gtgggaagtg ttgatcctga
      301 atatggtgaa atgacgttcc aggggagagt caccatgacc gaggacacgt ctacagacac
      361 ggcctacatg gagctgagta gcctgagatc tgaggacacg ggcgtgtatt actgtgcgat
      421 tggccctagc ggcaggtgga accactggtc cttcgagatc tggggacctg ggaccccaat
      481 caccatctcc tcagcc
//
LOCUS       KCXD01005660             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19945:16002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005660
VERSION     KCXD01005660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19945:16002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64142.1"
                     /translation="CATSPSGTWLFWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          146 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactgc aggcgcccgc
      121 tctgaggtcc acctggtgca atctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacgcagaaa aattccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggagc tgatcagtct gagatctgaa gacacggccc tgtattactg tgcgacatca
      421 cccagcggca cctggctatt ttggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01005661             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:10079:11975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005661
VERSION     KCXD01005661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:10079:11975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..493
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64143.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       412..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          104 a          139 c          146 g          106 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtctcaggtc
      121 cagctggtgc agtccggggc tgagatggag aagcctgggg cctcagtgaa gctctcctgt
      181 aaggcttctg gatacacctt gagcatctat gtcatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg aggcatcttc cctcttgttg gtacaacaaa ctacgcacag
      301 aagttccagg gcagagtcac gattaccgcg gacacgtcca caagcacagc ctacatggac
      361 ctgagcagcc tgggatctgg ggacacggcc gtctattatt gtgcgagagg ctactgtact
      421 ggtagtggtt gtaaccttac attcaaccgg ctcgatgtct ggggcccggg agtcccggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005662             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13622:17929
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005662
VERSION     KCXD01005662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13622:17929"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64144.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       404..413
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           84 a          141 c          136 g          103 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtccccagga aaggggctgg
      241 agtggattgg gtttttcggt ggttatggtg ggagcaccta ctacaacccc tccctccaga
      301 gtcgagtcac catttcagcc gacacgtcca aacaccagtt ctccctgata ctgacctctg
      361 tgaccgccgc ggacacggcc ctctactatt gtgcgagggg gaatatagca gcgactggca
      421 ttgactactg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005663             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:8029:15442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005663
VERSION     KCXD01005663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:8029:15442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64145.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       263..268
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           73 a           86 c           86 g           75 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg tagcctctgg attccccttc actacctctg
       61 gcatgcactg ggtccgccag gctccaggga aggggctcga gtggctgaca gttatatcgt
      121 ttgatgaaac taaggaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      241 tgtattactg tgcgagagat tcttacggcc gaggctttga ctcctggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005664             353 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:27682:12327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005664
VERSION     KCXD01005664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 353)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 353)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:27682:12327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..351
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..351
     V_segment       8..295
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <288..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64146.1"
                     /translation="CANGMSGLDYW"
     D_segment       296..300
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       310..351
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        352..>353
                     /gene="IGHG"
BASE COUNT           71 a           94 c          111 g           77 t
ORIGIN      
        1 acatgggggt gcacctggtg gagtctgggg gcggcttggc aaagcctggg ggatccctga
       61 gactctcctg tgcagcctct ggattcacct tcagtcgcta tgctatgcac tgggtccgcc
      121 aggctccagg gaaggggctg gagtgggtct caggtattac tagtggtggt aacacatact
      181 tcgcagactc cgtgaagggc cgattcaccc tctccagaga cgactcaaag aacacagtct
      241 ccttgcaaat gaacagtctg agacctgagg acacggccgt gtattactgt gcgaatggga
      301 tgtcagggct tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005665             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:7188:15206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005665
VERSION     KCXD01005665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:7188:15206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..471
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64147.1"
                     /translation="CARGLPTVFGVVITDVW"
     D_segment       419..430
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           94 a          137 c          136 g          106 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gacgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccctcgg agaccctgtc cctcacctgc actgtctctg
      181 gtgactcctt cagcggttac tactggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gcatatcagt gttagtcttg ggaagaccga ctacaacccg tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgaag gtgaactctg
      361 tgaccgccgc ggacacggcc gtatattact gtgcgagagg acttcctaca gtttttggag
      421 tggttattac ggatgtctgg ggcccgggag tcctggtcat cgtctcctca gcc
//
LOCUS       KCXD01005666             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:25991:12780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005666
VERSION     KCXD01005666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:25991:12780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..487
     V_segment       118..411
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64148.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       426..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          114 a          140 c          139 g           96 t
ORIGIN      
        1 acatggggga cccaacaaca acacccctcc acagaagccc ctggatcaca gctccttgcc
       61 atggactgga cctggaggat cctcttcttg gtggcagcag caacaggtgc ccactcccag
      121 gtgcagctgg tgcagtcggg ggctgaggtg aagcagccgg ggacatcagt gaaggtctcc
      181 tgcaaggctt ctggctacac cttcactagc tatggtatga actgggtgcg acaggcccag
      241 ggacaacggc ttgagtggat gggatggctc aacaccgaca ctgggaaccc aacgtatgcc
      301 cagggcttca aagaacgatt tacattctcc atggacacct ctatgaccac ggcatatctg
      361 cagatcagca gcctaaagac tgaggacacg gccgtatact actgtgcaag aagtttgggc
      421 tggcatgatt ataatgacgt cgcccttgac ttctggggcc agggagtcct ggtcgccgtc
      481 tcctcagcc
//
LOCUS       KCXD01005667             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13201:2050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005667
VERSION     KCXD01005667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13201:2050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..473
     V_segment       108..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64149.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       407..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>476
                     /gene="IGHG"
BASE COUNT          111 a          138 c          132 g           95 t
ORIGIN      
        1 acatggggac atccctcccc tacagaagcc ccagagcaca gcacctcacc atggactgga
       61 cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag gtccagctgg
      121 tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggttt
      181 ccggattcac cttcaccgat ttatccatac actggatacg acaggcccct ggaaaagggc
      241 ttcagtggat gggaagtgtt gatcctgcat atggtgaaat gataaacgca gagaagttcc
      301 agggcagagt caccatgacc gaggacacgt ctacagacac agccttcatg gaattgagca
      361 gcctgaaatc tgacgacacg gccgtatatt actgtgcgag tggccctagc ggcacctgga
      421 tcgactggtc cttcgatgtc tggggccctg gcaccccaat caccgtctcc tcaacc
//
LOCUS       KCXD01005668             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5812:21918
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005668
VERSION     KCXD01005668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5812:21918"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..490
     V_segment       139..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64150.1"
                     /translation="CAGGAYANLDYW"
     D_segment       439..443
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          106 a          124 c          154 g          108 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaaatg gtggagtctg ggggcggctt ggcaaagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag atactggatg
      241 aactgggtcc gccaggctcc aggaaagggg ctggagtggg tctcagctct taattatgat
      301 ggggatagta catactacgc agactccgtg aagggccgat tcaccatctc cagagacaac
      361 tcaaagaaca cgctctccct gcaaatgcac agcctgagag aagatgacac ggccgtttat
      421 ttctgtgcgg gcggggcgta cgctaacctc gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01005669             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17111:12674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005669
VERSION     KCXD01005669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17111:12674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64151.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          143 c          132 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccga gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gactactggg gccagggagc cctggtcacc gtttcctcag
      481 cc
//
LOCUS       KCXD01005670             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12662:18013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005670
VERSION     KCXD01005670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12662:18013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64152.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          135 c          130 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccatca ccaatagtta ctggaactgg atccgccagc ccccaggaaa ggggctggag
      241 tggattgggt ctatctatgg tggtactggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgccgt ttattattgt gcgagatatg aggatgaata cagtgactac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005671             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13435:19868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005671
VERSION     KCXD01005671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13435:19868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64153.1"
                     /translation="CARDAGVGATILYYYDFW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          135 c          137 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcagtg tctctggtgg
      181 ctccttcagt ggttactact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggttt atcggcggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa tcaattctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgttt attactgtgc gagagatgcg ggagtgggag ccacaatcct
      421 ttattactat gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005672             339 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11303:12455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005672
VERSION     KCXD01005672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 339)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 339)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11303:12455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..335
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..335
     V_segment       7..258
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>306
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64154.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       281..288
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..335
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        336..>339
                     /gene="IGHG"
BASE COUNT           71 a           93 c           99 g           76 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt tggtgattat
       61 ggcatgcact gggtccgcca ggctccggga aagggactgg agtggatctc atccattagg
      121 aacactggta aaatcgtata ctacgctgac tccgtgaagg gccgattcac catctccaga
      181 gacaacgcca agaactcgct gtctctgcga atgagcagcc tgagagccga ggacacggcc
      241 gtgtattact gtactagaat tggcgtcgga tctctggcaa cggctggtga ctattttgac
      301 cactggggcc agggagtcct ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01005673             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7188:10355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005673
VERSION     KCXD01005673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7188:10355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64155.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          111 c          154 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacg atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtcggg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaacaaagaa atactacgca gactctctga agggccgctt catcatctcc agagacaatt
      361 ccaagaatat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgacttctg gggccagggt gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005674             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15342:5412
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005674
VERSION     KCXD01005674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15342:5412"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64156.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       442..449
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          118 c          147 g          118 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gcaactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaagt aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaaatggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggaatgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01005675             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15790:12415
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005675
VERSION     KCXD01005675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15790:12415"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64157.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          112 a          142 c          133 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gtagcctgac atctgaggac acggccgtgt attactgtgc gactggccct agcggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacctc aatcaccatc tcctcagcc
//
LOCUS       KCXD01005676             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12262:16997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005676
VERSION     KCXD01005676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12262:16997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64158.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       412..417
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          113 a          141 c          129 g           91 t
ORIGIN      
        1 acatgggaca caaccaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggct cctcctcttg gtggcagcag ctacaggcgc ccactccgag
      121 gtccagctgg tacagtctgg ggctgaggtg aagaagcctg gggcctccgt gaaaatctcc
      181 tgccaggctt ctggatacac cttaaccgac cactacctgc actgggtgcg acaggctcct
      241 ggaaaaggac ttgagtggat gggaggtgtt catcctgaat atggtaaagt agactacaca
      301 cagaagttcc gagacagagt caccatcacc gcggacatgt cgacagagac agcctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtttatt actgtgtgac agtgggtccc
      421 taccattact ttgactactg gggccaggga gccctggtca ccgtttcctc agcc
//
LOCUS       KCXD01005677             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22733:10244
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005677
VERSION     KCXD01005677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22733:10244"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64159.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          112 a          132 c          158 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 aattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggtcca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtaga aatagaaact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg agacctgagg acacggccgt
      421 gtattactgt gcgtcgaacc tgcgtggaaa cacctacact tactggcggt cttttgactc
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005678             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7416:14812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005678
VERSION     KCXD01005678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7416:14812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64160.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          119 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg agtgaggtgc aactggtgga gtccggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatttcgt
      301 ctgatggaag taagaaatac tacgcaacct ctgtgaggga ccgcttcacc atctccagag
      361 acaattccaa gaacatactt tatcttcaaa tgaacaacct gaaattggaa gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005679             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12086:17493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005679
VERSION     KCXD01005679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12086:17493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..502
     V_segment       139..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64161.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       442..452
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          129 c          151 g          115 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catggagtct gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtacagcc actggattca ccttcagtag ttttggcatg
      241 agctgggtcc gccagcctcc agggaagggg ctggagtggg tctcatacat tagtaatagt
      301 ggtagtagca catactacgc agactccgtg aagggccgat tcaccatctc cagagacaac
      361 tcaaagaaca cgctctccct gcaaatgaac agcctgacag ctgaggacac ggccgtgtat
      421 cactgtgcga aacatcgttt cagcagctgg tcgtatttcc ttgacttctg gggccaggga
      481 atcctggtcg ccgtctcctc agcc
//
LOCUS       KCXD01005680             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19595:6723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005680
VERSION     KCXD01005680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19595:6723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64162.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       435..450
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          123 c          159 g          117 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagcac tggaagtcca cagtgttcca ttcggtgatc
       61 agcactgaac acagaggact caccatggag tctgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag gtggtggagt ctgggggcgg cttggcaaag
      181 cctgggggat ccctgagact ctcctgtgca gcctctggat tcaccttcag tacctatgct
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtctcagc cattagtgtt
      301 ggtggtagta catactacgc agactccgtg aggggccgat tcaccatctc cagagacaac
      361 tcagagaaca cgctctccct acaaatgaac agcctgagag ctgaggacac ggccgtgtat
      421 tactgtgcga aaggggatac agctacagtt tattacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ctgtctcctc agcc
//
LOCUS       KCXD01005681             360 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15825:16455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005681
VERSION     KCXD01005681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 360)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 360)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15825:16455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..358
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..358
     V_segment       7..273
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <265..>327
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64163.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       282..307
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       317..358
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        359..>360
                     /gene="IGHG"
BASE COUNT           75 a          102 c           97 g           86 t
ORIGIN      
        1 acatggggac tggtgaagcc ttcggagacc ctgtccctca cctgcggtgt ctctggtgtc
       61 tccatcaaca ttaactactg gagctggatc cgccagtccc cagggaaggg gctggagtgg
      121 attgggttta tctatggtgg tgatggctac accacctcca atccctccct caagagtcga
      181 gtcaccattt caacagacac gtccaagaac cagttttccc tgaagctgaa gtctgtgacc
      241 gccgcggaca ccgccgtgta ttactgtgcg agatatccgc gttacgagga tgatcacggt
      301 tactattctg tggaaattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005682             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17211:14362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005682
VERSION     KCXD01005682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17211:14362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64164.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          118 c          154 g          121 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggccgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005683             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6380:13313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005683
VERSION     KCXD01005683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6380:13313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64165.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          113 a          144 c          131 g           90 t
ORIGIN      
        1 acatggggga cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtggacta
      301 cacacagaag ttccgagaca gactcaccat caccgcggac atgtcgacag agacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005684             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21003:4835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005684
VERSION     KCXD01005684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21003:4835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64166.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          121 c          157 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaatatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaagatgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005685             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9738:9414
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005685
VERSION     KCXD01005685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9738:9414"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64167.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       267..272
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           79 a           78 c           91 g           72 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
       61 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      121 atgatgaaac taagacatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      181 acaattccaa aaacatggtg tatcttcaaa tgaacaacct gaaattggag gacacggcca
      241 tatattactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005686             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:12750:5932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005686
VERSION     KCXD01005686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:12750:5932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64168.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       437..444
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          111 c          148 g          122 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actttggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggattgg gtggcagtta tgtcatatga
      301 tgaaaatatg aaattctacg cagactctgt gaaggaccga ttcaccattt ccagagacaa
      361 ttccaagaac atggtttatc ttcaaatgaa caacctgaaa ttggaggata cggccgtata
      421 ttactgtgcg agaggggaat acagcaactc tattgactac tggggccggg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005687             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21244:20940
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005687
VERSION     KCXD01005687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21244:20940"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64169.1"
                     /translation="CAKGDTATPYYSLDSW"
     D_segment       437..448
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          128 c          158 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctcttttaag aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactacg
      241 ctatgcattg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattagca
      301 gtggtggtag aacattctac gcagactccg tgaagggccg attcaccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctggg aggtgaggac acggccgtgt
      421 attactgtgc gaagggggat acagctaccc cttactacag tttggattcc tggggccaag
      481 gggtcgtcgt cactggctcc tcagcc
//
LOCUS       KCXD01005688             435 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19978:6948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005688
VERSION     KCXD01005688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 435)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19978:6948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    58..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        58..433
     V_segment       58..351
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <343..>402
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64170.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       360..369
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..433
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>435
                     /gene="IGHG"
BASE COUNT           91 a          129 c          124 g           91 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctttgtg gtggcagcag ctacaggtgc ccagtcccag
       61 gtccagctgg tacagtccgg ggctgaggtg aagaagcctg gggcctcagt gaagctctcc
      121 tgtaaggctt ctggatacac cttcaacatc tatgccatca attgggtgcg acaggcccct
      181 ggacaggggc ttgagtggat gggagggatc atccctcttg ttgatatgac aaactacgca
      241 cagaggttcc agggcagagt cacgattacc gcggacacgt ccacagccac agccttcttg
      301 gaactgagca gcctgagatc tgacgacacg gccatttatt actgtgcgag agcccgggcc
      361 tacggtagcg gctaccgctc agactggttc ttcgatgtct ggggccctgg caccccaatc
      421 accatctcct cagcc
//
LOCUS       KCXD01005689             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17270:12177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005689
VERSION     KCXD01005689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17270:12177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..487
     V_segment       118..411
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64171.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       412..416
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          110 a          145 c          135 g           99 t
ORIGIN      
        1 acatggggaa acaaccacat ccctcctcta aagaagcccc tgggagcaca gctcatcacc
       61 atggactgga cctggaggct cctctttgtg gtggcagcag ctgcaggtgt ccagtcccag
      121 gtccacctgg tgcagtccgg ggctgaggtg aagaagcctg gggcctcagt gaaaatttcc
      181 tgcggggctt ctggattcac cttcgacacc catggtatca actgggtgcg acaggcccct
      241 ggacaaggac ttcagtggat gggagtgatc atccccctta ttggtatcac caactacgca
      301 aagaactctc agggcagagt cacactaacc gcggacacgt ccacaaacac agcctacatg
      361 gagctgaaca gcctgagatt tgaggacacg gccatctact actgtgcgag agaacgctgc
      421 acttctagtg tttgcgccgg gttccttgac tcctggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01005690             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:6892:10225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005690
VERSION     KCXD01005690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:6892:10225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..489
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64172.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       433..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT           98 a          149 c          133 g          111 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggctac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gcatatcagt gggagtagtg ggagcaccga ctacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaca gacacgtcca agagccactt ctccctgaaa ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga gttttccccc tacgactact
      421 cttggagtga tttttactca tactactttg actacttggg ccagggactc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005691             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22363:7749
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005691
VERSION     KCXD01005691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22363:7749"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64173.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       427..434
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          112 a          143 c          151 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgcccg
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgactta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgac cctgcaaatg gtgaaataat
      301 acacgcagat agtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgcgatctga ggacacggcc gtttattact gtgcgagagg
      421 gggcttcggt agcagtgtct ggtccaatct cgtctatggt ttggattcct ggggccaagg
      481 ggtcgccgtc accgtctcct cagcc
//
LOCUS       KCXD01005692             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15512:11903
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005692
VERSION     KCXD01005692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15512:11903"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64174.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          121 a          142 c          128 g           98 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg aaccaccttc accgaattat gcctgcactg ggttcgacag
      241 gcccctggaa aagggcttga gtggatggga agttttaatc ctatatatgg tgaaatttta
      301 caaacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01005693             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13201:21402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005693
VERSION     KCXD01005693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13201:21402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64175.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       455..467
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          115 c          155 g          126 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca ctgatatcgt
      301 atgatggaag taaggaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tattttcaac tgcacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagtg gggacatatg atagtggtta ttataccttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005694             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4637:19587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005694
VERSION     KCXD01005694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4637:19587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64176.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       432..436
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          123 c          157 g          114 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcaa cttcaattac tactacatta
      241 actgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt gacagtggtg
      301 gacatagcac atactatgcg gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag agtggtgggt ggtgccgcag gatacttcga cttctggggc cagggcgccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005695             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13797:11926
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005695
VERSION     KCXD01005695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13797:11926"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64177.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          145 c          137 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccgacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgaat ggatgggagg cgttgatcct gcatatggtg aatttacacc
      301 cggagagaat ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta
      361 catggagctg agcagcctga agtctgagga cacggccgtc tattactgtg cagccgggta
      421 tagcggcagc tggaaccact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005696             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21630:20036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005696
VERSION     KCXD01005696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21630:20036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64178.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       444..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          102 a          122 c          161 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcga cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgct gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcggg tattgacagt
      301 ggtgggggta ccacatacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccgaga acacactgta tcttcaaatg gacagcctga cagctgagga cacggctgtc
      421 tattactgtg cgagagtcgt gggtggtagt gctggatact ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005697             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:2327:14740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005697
VERSION     KCXD01005697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:2327:14740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..471
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64179.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..412
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..471
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           93 a          138 c          134 g          108 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct ctcctgcact gtctctggtg
      181 gctccttcag tggttactac tggacctgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggtt tatcggtggt ggtagtggga acaccgaata caacccctcc ctcaaaagtc
      301 gagtcaccat ttcaagagac acgtccaaga atcaattctc cctgaaactg acctctttga
      361 ccgccgcgga cacggccgtt tattactgtg cgagagatgc gggcgtggga gccacaatcc
      421 tttactacta tgactactgg ggcctgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005698             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24921:15389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005698
VERSION     KCXD01005698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24921:15389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..484
     V_segment       100..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64180.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       406..427
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           96 a          142 c          133 g          115 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca catgcgctgt ctctggtggc
      181 tctatcagca gtactaaatg gtggagctgg atccgccagc ccccagggaa agggctggag
      241 tggattgggt atatcagtgg tagtagtggt aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacgga cacgtccaac aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt ttattattgt gcgagatccc aatcctattg tagtgggctt
      421 tactgcttcg gctactacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01005699             396 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12702:12914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005699
VERSION     KCXD01005699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 396)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 396)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12702:12914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    34..394
                     /note="immunoglobulin heavy chain variable region"
     V_region        34..394
     V_segment       34..327
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <319..>363
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64181.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       334..341
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       349..394
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        395..>396
                     /gene="IGHG"
BASE COUNT           80 a           90 c          128 g           98 t
ORIGIN      
        1 acatggggct ttttgtttgc aggtgtccag tgtgaggtgc agctggtgga gtctgggggc
       61 ggcttggtaa agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc
      121 agttatttct acatgagctg ggtccgtcag gctccaggga aggggctgga gtggatctca
      181 agtattgaca gtggtgggac taccgcaaat tatgcagact ccgtgagggg cagattcatc
      241 atctccagag agaacgccaa gaatatagtg tatcttcaaa tggacagcct gagagctgag
      301 gacacggctg tctattattg tgcgagagcg cgcggggtga tcattacata ctttgactcc
      361 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005700             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4909:9746
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005700
VERSION     KCXD01005700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4909:9746"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..504
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64182.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       441..461
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          113 a          108 c          157 g          128 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaga tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggactg ggtgacagtt atatcgtatg
      301 atggaagtac gaagtactat gtagactctg tgaaggaccg attcaccatc tccagagaca
      361 attcgaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attattgtgt gagagtagac tgtagtggtg gtgtctgcta ctttgactac tggggccagg
      481 gagtcctggt caccgtctcg tcagcc
//
LOCUS       KCXD01005701             280 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19815:12586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005701
VERSION     KCXD01005701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 280)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 280)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19815:12586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..278
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..278
     V_segment       8..205
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <197..>247
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64183.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       216..223
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..278
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        279..>280
                     /gene="IGHG"
BASE COUNT           68 a           63 c           87 g           62 t
ORIGIN      
        1 acatgggggc atgcactggg tccgccaggc tccagggaag ggactggagt gggtggcact
       61 gatatcgtat gatggaagta agaaatacta cgcagactct gtgaaggacc gattcaccct
      121 ctccagagac aattccgaga acatcctata tcttcaaatg aacaacctga aattggagga
      181 cacggccgtg tatttttgtg cgagagttgg agagggtact ggtggtgcgg aggactttga
      241 cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005702             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5933:10070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005702
VERSION     KCXD01005702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5933:10070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..477
     V_segment       126..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64184.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       424..429
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          111 a          137 c          138 g           93 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 agctctcctg caaggcttct ggatacagct tcaacatcga tgccatcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagggatcat ccctcttgtc ggtataacaa
      301 actacgcaca gaagttccag ggcagagtct cgattaccgc ggacacgtcc acaagcacag
      361 cctacatgga actgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgatcc
      421 aagggaacag ccagtttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005703             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19336:14776
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005703
VERSION     KCXD01005703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19336:14776"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64185.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       442..453
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          118 c          153 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca ttgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcca ggctccaggg aagggtctgg agtgggtggc agttatgtcg
      301 catgatggaa ctaagaaatt ctacgcagac tctgtgaagg accgattcac catctccagg
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgagattgga ggacgcggcc
      421 gtgtattact gtgcgagagg agactacggt aacagccttg actactgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01005704             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19961:14128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005704
VERSION     KCXD01005704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19961:14128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64186.1"
                     /translation="CARYPYSGSYLRYFDYW"
     D_segment       398..412
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          135 c          135 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtccagtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggcgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctcctttagt ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat gttagtatta gtgggagcac cgactacaac ccctccctca agagtcgagt
      301 caccatttca acagacacgt ccaagaacca gttctccctg aagttgacct ctgtgaccgc
      361 cgcggacacg gccgtgtatt actgtgcgag atatccatat agtgggagct acttgaggta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005705             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17207:12953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005705
VERSION     KCXD01005705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17207:12953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64187.1"
                     /translation="CARYEGAAAGTWFFDYW"
     D_segment       403..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           90 a          142 c          130 g          106 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcacct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcacca atcattactg gaactggatc cgccagcccc ccgggaaggg actggagtgg
      241 gttgggtctc tctatggtgc tactgggagc accaactata atccctccct caagagtcga
      301 gtcagcattt caacagacat gtccaagaac caattttccc tgaaactgac ctctgtgacc
      361 gccgcggaca ccgccgtcta ttactgtgcg agatatgagg gggcggcagc tggaacctgg
      421 ttctttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005706             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:25577:9058
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005706
VERSION     KCXD01005706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:25577:9058"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64188.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       405..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          100 a          134 c          136 g          109 t
ORIGIN      
        1 actggggaaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctcctt cagcggttac tattggagct ggattcgcca gcccccaggg aagggactgg
      241 aatggattgg gtatattagt gccagtactg ggagcaccga ctacaacccc tccttcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgagg ctgacgtctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagaga gaaatactat agtggtagtt
      421 ataaacacaa ctggttcgat gtctggggtc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005707             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15262:11860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005707
VERSION     KCXD01005707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15262:11860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64189.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          120 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttc
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg tagcctctgg attcacgttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtactttcgt
      301 ctgatggaag taacaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaactccaa gaacacacta tatcttcaaa tgaataacct gaaactggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005708             406 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15068:14557
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005708
VERSION     KCXD01005708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 406)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 406)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15068:14557"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    41..404
                     /note="immunoglobulin heavy chain variable region"
     V_region        41..404
     V_segment       41..334
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <326..>373
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64190.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       338..345
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       360..404
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        405..>406
                     /gene="IGHG"
BASE COUNT           81 a          121 c          114 g           90 t
ORIGIN      
        1 acatgggctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
       61 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      121 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      181 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      241 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      301 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      361 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005709             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13846:15975
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005709
VERSION     KCXD01005709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13846:15975"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64191.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          119 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttc
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacacacta tattttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005710             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14741:21353
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005710
VERSION     KCXD01005710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14741:21353"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..497
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64192.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       417..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          113 a          137 c          144 g          109 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccacctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacc ttcagcatct cttccatcag ttgggtgcga caggcccctg
      241 gacaagggct tgggtggata ggagggatca tccctcttgt tggtatgaca aactacgaac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacgaataca gtcttcatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtctacta ttgtgcgaca ggggtatatt
      421 accaggatga aaacggttat ttttatgtcg gcggtgactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01005711             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7998:3984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005711
VERSION     KCXD01005711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7998:3984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64193.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          105 a          140 c          138 g           97 t
ORIGIN      
        1 acatgggggc atccaacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtaca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatggtg
      301 ttccagggca gagtcacctt gaccgaggac acgtctatag acacagccta catggagttg
      361 agcagcctga gatctgagga cacggccgtg tattactgcg cgattggccc tagcggcaac
      421 tggaacggct ggtccttcga tatctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005712             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8513:4205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005712
VERSION     KCXD01005712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8513:4205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64194.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       416..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          110 a          143 c          138 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ctttctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccc tcaccgaagt gtccactcac tgggtgcgac
      241 aggcccccgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc tacatggaat
      361 tgagcagcct aagatctgag gacacggccg tgtattactg tgcgattgga cctaccggca
      421 ggtggaacgg ctggtccttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01005713             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20351:6624
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005713
VERSION     KCXD01005713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20351:6624"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64195.1"
                     /translation="CARVTGIDESSVEYFEFW"
     D_segment       444..450
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..513
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          119 a          121 c          151 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag tctccagggc aggggctgga atgggtggca cttatatcgt
      301 atgatggaac taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagta accggtatag atgaaagttc cgttgaatac ttcgagttct
      481 ggggccaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005714             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13140:17518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005714
VERSION     KCXD01005714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13140:17518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64196.1"
                     /translation="CTRIWCPRDLTSGCNWFDVW"
     D_segment       457..465
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          104 a          128 c          159 g          126 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggagcacct cgtggagtct gggggaggcc tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagg ctctggattc atctttggtg attatggcat
      241 gcattgggtc cgccaggctc cgggaggggg actggagtgg gtctcgtcca ttagtaacac
      301 tggtaaaagt atatactaca ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgcccagaac tcggtgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact agaatttggt gtccccgcga tttaaccagc ggctgtaatt ggttcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005715             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11536:18333
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005715
VERSION     KCXD01005715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11536:18333"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..432
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64197.1"
                     /translation="CARGVDNHHYSDTEFDLW"
     D_segment       454..460
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          116 a          121 c          149 g          124 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgttgct
      121 atattaaaag gtgtccagtg tgtggagcag ctggtggagt ctgggggagg cttggtacag
      181 ccgggggcgt ccctgagact ctcctgtgca gcctctgaat tcaccttcag tagctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctggagt ggatatcagg tattaacatt
      301 ggcggtgaca catactaccc agactctgtg aagggtcggt tcaccatctc cagagacaat
      361 gccaagaact ccttgtatct tcaaatgaac agcctgagag ctgaggacac tgctgtatat
      421 tattgtgcaa gaggcgtaga taaccaccac tacagtgata cggagtttga cctctggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005716             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14770:2854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005716
VERSION     KCXD01005716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14770:2854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..474
     V_segment       108..399
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64198.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       413..419
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..474
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          112 a          137 c          133 g           94 t
ORIGIN      
        1 acatggggac atccctcccc tacagaagcc ccagagcaca gcacctcacc atggactgga
       61 cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag gtccagctgg
      121 tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc tgcaaggttt
      181 ccggatacat cttaaccgaa ttatccatcc actgggtgcg acaggcccct ggaaaagggc
      241 ttgagtggat gggaagtgtt gatcctcaat atggtgaaat gatagacgca gagaaattcc
      301 agggcagagt caccctgacc gaggacacgt ctacagacac agcctacatg gagctgagca
      361 gtctgagatc tgaggacacg gccgtgtatt actgtgcgac atcatccagc ggcacctggc
      421 tatactggta cttcgatatc tggggccctg gcaccccaat caccctctcc tcagcc
//
LOCUS       KCXD01005717             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:26109:14728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005717
VERSION     KCXD01005717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:26109:14728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..265
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <257..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64199.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       276..284
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           77 a           81 c           91 g           79 t
ORIGIN      
        1 acatgggcag ccggaggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag
       61 tttctatggc ttgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt
      121 aatttcgaat gatgaaaata acaaatacta cgcagactct gtgaaggacc gattcaccat
      181 ttctagagac aattccatga acatgctatt tcttcaaatg aacaacctga acttggacga
      241 cacggccgtc tattactgtg tgagagatga tttaggcagc ggcttagggt cctggggcca
      301 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005718             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:3816:15340
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005718
VERSION     KCXD01005718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:3816:15340"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..493
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64200.1"
                     /translation="CATGRIGSSVWSSLFNGLDSW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>499
                     /gene="IGHG"
BASE COUNT          116 a          143 c          144 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccgtcaccga tttatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggagttgt taatcctgta aatggagaaa tgatacacgc
      301 agagaagttc caggccagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttggtc agcctgacat ctgaggacac ggccatctat tactgtgcga cagggaggat
      421 cggtagcagc gtctggtcca gcctcttcaa cggcttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tccgcagcc
//
LOCUS       KCXD01005719             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15519:7040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005719
VERSION     KCXD01005719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15519:7040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..460
     V_segment       94..390
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64201.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       406..411
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..460
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           91 a          140 c          131 g          100 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcaggg gtcgggccca
      121 gggctggtga agccttcgga gaccctgtcc ctcacctgcg ctgtttctgg tgactccatc
      181 aacagtggct actactggag ttggatccgc caacccccag ggagggggct ggagtggatt
      241 gggtctatcg gtggtagtag tggcagcacc tactacaacc cctccctcaa gagtcgagtc
      301 accctttcaa aagacacgtc caggaaccag ttctccctga aactgagctc tgtgaccgcc
      361 gcagacacgg ccgtttatta ctgtgcgaga aaacttccag gtctccaact aaccggtttc
      421 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005720             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16379:17288
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005720
VERSION     KCXD01005720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16379:17288"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..460
     V_segment       100..393
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64202.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       395..401
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..460
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          112 c          147 g          114 t
ORIGIN      
        1 ggtgtttctg ttcggcgatc agcactaaac acagaacata ccatggagtt tgtgctgagc
       61 tgggttttcc ttgttgctct tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct
      121 gggggcggct tggcaaagcc tggggggtcc ctgagactct cctgcgcagc ctctggtttc
      181 agcttcagtt tctactatat gacctgggtc cgccaggctc cagggaaggg gctggagtgg
      241 atctcaggta ttgacactgg tggggatagc acctactatg cagactccgt gaagggcaga
      301 ttcaccatct ccagagagaa cgccaagaag acactgtatc ttcagatgga cagcctgaga
      361 gctgaggaca cggctgtcta ttactgtgcg agagtagtgg gtggtgccgc cggatacttc
      421 gatttctggg gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005721             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21397:5665
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005721
VERSION     KCXD01005721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21397:5665"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..516
     V_segment       141..433
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64203.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       447..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          119 a          124 c          151 g          124 t
ORIGIN      
        1 acatggggtg ggagaggaga cccagccttg ggatttccag ctgtctccag ttggcgatca
       61 gcactgaaca caggagactc gccatggagt ttgtactgag ctgggttttc cttgttgcta
      121 tattaaaagg tgtccggtgt gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggcgggtc cctgagactc tcctgtgcag cctctggatt caccttcagt gactttgcca
      241 tgagctgggt ccgccaggct tctgggaaag gactggagtg ggttggctat attagaacca
      301 aatataacaa ttacgcggca gaatacgccg catcggtgaa aggcaggttc accatctcca
      361 gagatgattc aaagaacacg atatatctgc aaatgagtag cctgaaaacc gaggacacgg
      421 ccgtgtatta ctgcaccaca tggagatatt actatagtac tggttacccc acctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005722             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:24753:4206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005722
VERSION     KCXD01005722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:24753:4206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64204.1"
                     /translation="CAKDAFGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          119 c          154 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatctcga
      301 atgatggaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tgttttactg tgcgaaagac gcctttggca gcggctgtga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005723             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5886:12155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005723
VERSION     KCXD01005723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5886:12155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64205.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          114 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtaactatg
      241 gaatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaga taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01005724             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16611:16675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005724
VERSION     KCXD01005724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16611:16675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64206.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          119 c          145 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca cctttagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005725             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18765:5923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005725
VERSION     KCXD01005725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18765:5923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64207.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       441..449
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          112 c          148 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgcgatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcaaccgga
      181 ggggtccctg agactctcct gtgcagcctc tggattcact ttcagtttct atggcttgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt cgaatgatga
      301 aaataacaaa tactacgcag actctgtgaa ggaccgattc accatttcta gagacaattc
      361 catgaacatg ctatttcttc aaatgaacaa cctgaacttg gacgacacgg ccgtctatta
      421 ctgtgtgaga gatgatttag gcagcggctt agggtcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005726             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:17804:19753
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005726
VERSION     KCXD01005726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:17804:19753"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..494
     V_segment       134..425
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64208.1"
                     /translation="CTKDDVVVFSGPVDW"
     D_segment       447..453
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          105 a          116 c          149 g          126 t
ORIGIN      
        1 acatggggga ggagcccagc cctgggattc ccaggtgttt tcatttgtga tcagcactga
       61 acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag ggtgaggtgc aactggtgga gtctgggggc ggcttggcga agcctggggg
      181 gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtaactact ggatgtactg
      241 ggttcgccag gcacctggga aggggctgga gtgtatctcc ggtattaata ctgctggtgg
      301 tagcacgtac tatgcagact ccgtgaaggg cagattcacc atctccagag agaacgccaa
      361 gaacactcta tatcttcaaa tgaacagcct gagagctgag gacacggctg tctattactg
      421 tacgaaagat gacgttgtcg ttttttctgg tcccgtagac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005727             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14903:8684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005727
VERSION     KCXD01005727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14903:8684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64209.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       430..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          124 c          149 g          105 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcggcca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacagtgt caccgaatta tcgattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgtaaaag gtgaagaaat
      301 tcacggagag gagttccagg acagagtcac catgaccgag gacccgtcta cagacacagc
      361 ctacatggag ttgagcaacc tgagatctga ggacacggcc gtgtattatt gtgcgagtgg
      421 gtttagtgtc tggttattta acgacgtttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005728             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10459:14930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005728
VERSION     KCXD01005728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10459:14930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64210.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       442..446
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          139 c          144 g          101 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggttttcgga tacaccttca gcgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgacac tgtctctgac ggagtgatat
      301 acgcagagaa cttccagggc agagtcgcca tgaccgagga cacgtctaca gacacagcct
      361 acatggaatt gagcagcctg agatctgagg acacggccgt ttattactgt gcgagaggtt
      421 tatcaccaga cgtcttcggt ttcctcgggc ttggctactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005729             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6856:10826
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005729
VERSION     KCXD01005729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6856:10826"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64211.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       443..447
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          114 c          152 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggcggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtgacagtt atctcatttg
      301 atgaaactaa gaaatactac gcagactctg tgagggaccg attcaccatc tccagagaca
      361 attccaaaaa catggtatat cttcacatga acaacctgaa attggaggac acggccgtat
      421 attactgtgc gagagatgtc agggggacgg ggtttgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005730             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10440:15791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005730
VERSION     KCXD01005730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10440:15791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64212.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       442..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          110 a          114 c          160 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcactgata tcgtttgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatggaca acctgaaatt ggaggacacg gccgtgtatt
      421 tttgtgcgag agttggagag ggtactggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005731             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16132:16931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005731
VERSION     KCXD01005731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16132:16931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..502
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64213.1"
                     /translation="CARGWNSVEVEVDTHYGLDSW"
     D_segment       421..427
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>506
                     /gene="IGHG"
BASE COUNT          114 a          145 c          143 g          104 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 agctttcctg caaggcttct ggattcacct tcgacgacta tgctatcaac tgggttcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat ccctcttgtt catataacaa
      301 cctacgcaga gaagctccag ggcagactca cgattaccgc ggacacctcc acagccacag
      361 cctacatgga actgaccagc ctgagatctg aggacacggc cgtctattac tgtgcgcgag
      421 gctggaatag tgttgaggta gaggttgaca cacactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tctgcc
//
LOCUS       KCXD01005732             373 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10019:10723
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005732
VERSION     KCXD01005732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 373)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 373)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10019:10723"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..371
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..371
     V_segment       8..296
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>340
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64214.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       304..312
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       326..371
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        372..>373
                     /gene="IGHG"
BASE COUNT           83 a           97 c          108 g           85 t
ORIGIN      
        1 acatggggag gtccagctgg tgcagtctgg ggccgaagtg aagaagcctg gggcctcagt
       61 gagggtctcc tgcaaggttt ccggacacac cttcagcgaa ttatccattc actgggtgcg
      121 acaggccccc ggaaaagggc ttgagtgggt gggaggtttt gctcctatat atggtgaaat
      181 cctacacaca gacaagttcc agggcagagt caccttgacc gaggacacgt ctacagacac
      241 cgcctatatg gagttgagca gcctgagatc tgaggacacg gccgtatatt actgtgtggc
      301 ggctgatagt ggttaccctt tttactactt cgatatctgg ggccctggca ccccaatcat
      361 catctcctca gcc
//
LOCUS       KCXD01005733             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14252:16648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005733
VERSION     KCXD01005733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14252:16648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64215.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          112 a          145 c          140 g           95 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgagttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagcct gtcatctgag gacacggccg tgtatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01005734             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12659:15685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005734
VERSION     KCXD01005734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12659:15685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..348
     V_segment       8..261
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <255..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64216.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       276..288
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..348
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           77 a           89 c          110 g           74 t
ORIGIN      
        1 acatggggcc tggggcctca gtaaaggtct cctgccaggt ttccggatac accttcagtg
       61 aaatgtccat gcactgggtg cgacaggccc ctggaaaagg gcttgagtgg atgggatgtg
      121 ttgctcctgg aaatggtgaa ataatacacg cagagaactt ccagggcaga gtcaccatga
      181 ccgaggacac gtctacagac acagcctaca tggagctgag tagcctgaga tctgaggaca
      241 cggccgtgta ttactgtgcg acagggaggt tcgggagcag cgtctggtcc agcctcttct
      301 acggtttgga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005735             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:5584:5373
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005735
VERSION     KCXD01005735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:5584:5373"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64217.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       288..293
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           82 a           83 c          102 g           83 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc aacctggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agtaagtttg gcatacactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttatttcgt ctgatggaag taacaaatac tacgcaagct
      181 ctgtgaagag ccgattcacc atctccagag acaattccaa gaacatacta tatctgcaaa
      241 tgaacaactt gaaattggag gacacggccg tctattactg tgcgagagat gatcttggga
      301 ccggttttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005736             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19875:8819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005736
VERSION     KCXD01005736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19875:8819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64218.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          110 c          154 g          121 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcatg ttcagtaact ttggcatcca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg tcagttatat cgtatgatgt
      301 aactgtgaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacacg ctatatcttc aaatgcacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ttgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggag tcctggtcac
      481 cgtctcgtca gcc
//
LOCUS       KCXD01005737             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12940:5133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005737
VERSION     KCXD01005737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12940:5133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64219.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          121 a          142 c          136 g           96 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gccaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      301 gtagacgcag agaaattcca gggcagagtc accattaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag tctgagatct gaggacacgg ccgtgtatta ctgtgcgaca
      421 tcatccagcg gcacctggct atactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01005738             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21624:8388
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005738
VERSION     KCXD01005738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21624:8388"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64220.1"
                     /translation="CVRDRRVQSLSWFDAW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          125 c          159 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgctcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc
      301 tggtggggat agcacatact atgcagactc cgtgaagggt agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaagt ggacagcctg agagctgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg cctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005739             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2480:14382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005739
VERSION     KCXD01005739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2480:14382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64221.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       413..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          107 a          139 c          138 g           98 t
ORIGIN      
        1 acatggggga gcatccaaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaaggactt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatgg
      301 tgttccaggg cagagtcacc atgaccgagg atacgtctat agacacagcc tacatggagt
      361 tgagcagcct gagatctgag gacacggccg tttattactg cgcgattggc cctagcggca
      421 actggaacgg ctggtccttc gatatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01005740             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18548:12072
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005740
VERSION     KCXD01005740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18548:12072"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64222.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          136 c          142 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgatttgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgaatatggt gaaatgacgt
      301 tccaggggag agtcaccatg accgaggaca cgtctacaga cacggcctac atggagctga
      361 gtagcctgag atctgaggac acgggcgtgt attactgtgc gattggccct agcggcaggt
      421 ggaaccactg gtccttcgag atctggggac ctgggacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01005741             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11659:11876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005741
VERSION     KCXD01005741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11659:11876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64223.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       431..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          124 c          157 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagcacc tatgctatgc
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagtacata ctacgcagac tccgtgaggg gccgattcac catctccaga gacaactcag
      361 agaacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc gtatattact
      421 gtgcgaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01005742             304 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15610:10950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005742
VERSION     KCXD01005742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 304)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 304)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15610:10950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..302
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..302
     V_segment       8..226
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>271
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64224.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       227..237
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..302
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        303..>304
                     /gene="IGHG"
BASE COUNT           73 a           73 c           84 g           74 t
ORIGIN      
        1 acatggggga tttaccttcg acaactatgg aatcaactgg gtgcggcagg cccctggaca
       61 agggcttgag tggatgggcg tggtcatccc ccttgttggt attattaatt atgcagagaa
      121 cttccagggc agagtaacga ttaacgcgga cacgtccata aacacagcct tcatggaatt
      181 caggagcctg agatctgacg acacggccat ttatttctgt gcgagagaat actgtacaac
      241 tactgattgc gccgggttct ttgactactg gggccaggga gtcatggtca ccgtctcctc
      301 agcc
//
LOCUS       KCXD01005743             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:12788:7389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005743
VERSION     KCXD01005743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:12788:7389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64225.1"
                     /translation="CAIGPSGSWNNWSFDIW"
     D_segment       418..429
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          140 c          134 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttcttatgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagttgt ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggca agtgttgatc ctgcatatgg tgaaatgatg
      301 ttccagggta gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgtg tattactgtg cgattggccc tagtggcagc
      421 tggaacaact ggtccttcga tatctggggc cgtggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005744             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18617:6013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005744
VERSION     KCXD01005744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18617:6013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64226.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          113 a          142 c          130 g           91 t
ORIGIN      
        1 acatggggga cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttctggatac accttaaccg accactacct acactgggtg cgacaggctc
      241 ctggaaaagg acctgagtgg atgggaggta ttcaccctga gtatggtaaa gtagactaca
      301 cacagaagtt ccgagacaga gtcaccatca tcgcggacat gtcgacagag acagtctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgttta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgacttc tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005745             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23397:3299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005745
VERSION     KCXD01005745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23397:3299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..490
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64227.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       432..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>497
                     /gene="IGHG"
BASE COUNT          114 a          138 c          142 g          103 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcggcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacatct tcaccgaatt atccatgcac tggctgcgac
      241 aggcccctgg aaaagggctt gagtggttgg gaagtgttga ttataaatat gatgaagtaa
      301 tccacgcaga caatttccag gacagagtca gcatgaccga ggacacgtcc acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcggcgg
      421 gccttggggg atatttactg cttactgaat atttccagtt ctggggccag ggcgccctgg
      481 tcaccgtctc ttccgcc
//
LOCUS       KCXD01005746             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11809:15578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005746
VERSION     KCXD01005746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11809:15578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64228.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       435..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          105 a          126 c          159 g          127 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtctg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agctttggcg atcatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca tcagtaatac
      301 tggtaaagcc gtacactacg ctgactccgt gaagggccga ttcaccattt ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttattgttgt agcgattact atagtggtag ttattactat tggggctacg gcttggattc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005747             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:10436:14497
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005747
VERSION     KCXD01005747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:10436:14497"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64229.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          140 c          133 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggacctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatgt ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01005748             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22907:15678
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005748
VERSION     KCXD01005748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22907:15678"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64230.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          120 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccac tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaagttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga ctactggggc cggggcgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005749             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9851:2101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005749
VERSION     KCXD01005749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9851:2101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64231.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       440..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          115 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc tattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ttattttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg caggttctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtggct gttatgtcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaag tgaacaccct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtctttggcg ggggacttga ctactggggc cagggagtcc
      481 cggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005750             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20562:7755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005750
VERSION     KCXD01005750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20562:7755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..494
     V_segment       119..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64232.1"
                     /translation="CARARAYGSGYRSDWFFDVW"
     D_segment       421..430
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..494
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          148 c          138 g          102 t
ORIGIN      
        1 acatggggat agcaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccagctg gtacagtccg gggctgaggt gaagaagcct ggggcctcag tgaagctctc
      181 ctgtaaggct tctggataca ccttcaacat ctatgccatc aattgggtgc gacaggcccc
      241 tggacagggg cttgagtgga tgggagggat catccctctt gttgatatga caaactacgc
      301 acagaggttc cagggcagag tcacgattac cgcggacacg tccacagcca cagccttctt
      361 ggaactgagc agcctgagat ctgacgacac ggccatttat tactgtgcga gagcccgggc
      421 ctacggtagc ggctaccgct cagactggtt cttcgatgtc tggggccctg gcaccccaat
      481 caccatctcc tcagcc
//
LOCUS       KCXD01005751             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13306:14800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005751
VERSION     KCXD01005751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13306:14800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64233.1"
                     /translation="CARAGFSGSESFYGLDIW"
     D_segment       403..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           89 a          139 c          135 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc tcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt ctttggggac cctgtccctc acctgcgatg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccaggcc cccgggaagg gactggaatg
      241 gattggacgt ttctctggta gtggtggaaa caccgactac aacccctccc tcacctctcg
      301 agtcaccttt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga aatctgtgac
      361 cgccgcggac acggccgtct atttctgtgc gagagccgga tttagcggca gcgaaagttt
      421 ctacggtttg gatatttggg gccaaggggt cgccgtcacc gtctcctcag cc
//
LOCUS       KCXD01005752             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:25941:13510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005752
VERSION     KCXD01005752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:25941:13510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64234.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       444..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          122 c          159 g          118 t
ORIGIN      
        1 acatggggga cctctgggag aggagcccag ccccagagtt cccaggcgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgtgg
      121 ctcttttgaa aggagtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggtaa
      181 agccgggggg gtccctgaga ctctcctgcg tagtctctgg attcagcttc agttatttct
      241 acatgagctg ggtccggcag gctccaggga aggggctgga gtggatctca agtattgaca
      301 gtggtgggac taccacaaat tatgcagact ccgtgagggg cagcttcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gaaagccgag gacacggctg
      421 tctattattg tgcgagagcg cgcggggtga ttattacata ctttgactcc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005753             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23918:5527
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005753
VERSION     KCXD01005753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23918:5527"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..332
     V_segment       4..259
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64235.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       270..284
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..332
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           74 a           89 c           91 g           80 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgactactg
       61 gatgtactgg gttcgccaga cacctgacca ggggctggag tggatctcag ctattgatag
      121 tgctggtact actaccacat actatgcaga ctccgtgaag ggcagattca ccatctccag
      181 agagaacgcc aaaaacacac tgtatcttca gatggacagc ctgagaactg aggacacggc
      241 tgtctattac tgtgcgagag ttccgggcct agtggtattt actggttcgc ttgactactg
      301 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005754             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21269:19270
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005754
VERSION     KCXD01005754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21269:19270"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64236.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          117 c          160 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctccgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005755             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13219:17563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005755
VERSION     KCXD01005755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13219:17563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..482
     V_segment       113..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64237.1"
                     /translation="CARERCSASSCAGFLDSW"
     D_segment       412..419
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          106 a          138 c          143 g           97 t
ORIGIN      
        1 acatggggac cacatccctc ctctaaagaa gcccctggga gcacagctca tcaccatgga
       61 ctggacctgg aggctcctct ttgtggtggc agcagctaca ggtgtccagt cccaggtcca
      121 gctggtacag tccggggctg aggtgaagaa gcctggggcc tcagtgaaag tttcctgcaa
      181 ggcttctgga ttcaccctcg acaactatgg catcaactgg gtgcgccagg cccccggaca
      241 ggggcttgag tggatgggag tgatcatccc ccttattgga ataataaact acgcagagaa
      301 cgtccagggc agagtcgcga tttccgcgga cacgtccata aatacagcct acatggaggt
      361 gcgcagcctg agatctgagg acacggccat ctattactgt gcgcgagaac gttgtagtgc
      421 tagcagttgc gccggattcc tagactcctg gggccaggga gccctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01005756             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13005:14770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005756
VERSION     KCXD01005756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13005:14770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64238.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          129 a          143 c          132 g           90 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagcg acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacagat tcaccgaatc atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gaatggatgg gaagtgttga tcctgaatat ggtgaaatga
      301 taaacacaga gaaattccag gacagagtca ccctgaccga ggacacgtct acagacacag
      361 cctacatgga tctgagcacc ctgagatctg acgacacggc catatattac tgtgcgagag
      421 cccatagcgg cagctggaat aactggtact tcgatctctg gggccctggc accccaatca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005757             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20042:11287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005757
VERSION     KCXD01005757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20042:11287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64239.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       436..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          125 c          157 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggtgata gcacatacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgtt tcttcaaatg gacagcctga gagctgacga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005758             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23517:17258
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005758
VERSION     KCXD01005758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23517:17258"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..460
     V_segment       85..384
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64240.1"
                     /translation="CARVQGGSYYYGGGYFEFW"
     D_segment       389..405
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..460
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT          100 a          137 c          118 g          107 t
ORIGIN      
        1 acatgggggt gactcctgtg ccccaccatg gacacgcttt gctacacact cctgctactg
       61 accgtcccgt cctgggtctt gtcccaggtg accttgaagg agtctggtcc tgcgctggtg
      121 aaacccacac agaccctcac gctgacctgc actttctctg ggttctcatt cagttcttct
      181 ggaacaggtg tgggctggat ccgtcagccc ccagggaagg ccctggaatg gcttgcaagc
      241 atttattgga atgatactaa attccacagc acaacgctga agttcaggct caccatctcc
      301 aaggacacct ccaaaaacca ggtggttcta acaataacca acgtggaccc tgtggacaca
      361 gccacatatt actgtgcacg ggtacaaggt ggtagttatt actacggtgg gggatacttc
      421 gagttctggg gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005759             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:25250:11010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005759
VERSION     KCXD01005759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:25250:11010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..485
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64241.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       439..448
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>491
                     /gene="IGHG"
BASE COUNT          111 a          117 c          149 g          114 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagccggggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt ggcatacact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg catgatgaaa
      301 ctaggaaata ctacgcagac tctgttaggg accgattcac cgtctccaga gacaattcca
      361 acaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtgtattact
      421 gtacgagaga cgcatttggc agcggctgtg actactgggg cctgggagtc ctggtcaccg
      481 tctccccagc c
//
LOCUS       KCXD01005760             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15343:9360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005760
VERSION     KCXD01005760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15343:9360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..327
     V_segment       8..262
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <255..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64242.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       269..278
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           60 a          101 c           95 g           73 t
ORIGIN      
        1 acatggggcc ttcagagacc ctgtccctca cctgcgctgt ctctggtggc tccatcagcg
       61 gttactggtg gggctggatc cgccagtccc cagggaaggg gctggagtgg attgggtttt
      121 tcggtggtag tggtgggagc acctactaca aatcctccct ccagagtcgc gtcaccattt
      181 caaccgacac gtccaagaac cagttctccc taatactgac ctctgtgacc gccgcggaca
      241 cggccctcta ttactgtgcg agggggaata tagcagcgac tggcattgac tactggggcc
      301 agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005761             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23269:7410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005761
VERSION     KCXD01005761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23269:7410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..489
     V_segment       126..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64243.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       422..430
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          119 a          142 c          134 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccccccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaact acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ccgaagtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggacacacct acaccgaagt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttgc tcctatatat ggtgaaatac
      301 taaacacaga caagttccag ggcagagtca ccatgaccga ggacacgtct gcagacacag
      361 cctacatgga gttgagcagc ctgagatctg aggacacggc cgtatattac tgtgtggcgg
      421 ctgatagtgg ttaccctttt tactacttcg atatctgggg ccctggcacc ccaatcagca
      481 tctcctcagc c
//
LOCUS       KCXD01005762             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17571:14325
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005762
VERSION     KCXD01005762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17571:14325"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..483
     V_segment       123..416
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64244.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       426..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          100 a          144 c          131 g          110 t
ORIGIN      
        1 acatggggag tctccctcac cgcacagctg ggatctcagt gcttcctttt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcaccc tcctactggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggagcag aggtgaaaag gcccggggag tctctgaaga
      181 tctcctgtaa gacttctgga tacagcttta ccagttactg gatcacctgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatggggg cgattgatcc tagtgattct gctaccaaat
      301 acagcccgtc cttccaaggc caggtcacca tttcagccga caagtccatc accaccgcct
      361 acctagaatg gagcagcctg aaggcctcgg acaccgccac gtatttttgt gcgaaaggtc
      421 ccggagtgat tattaactac tttgactact ggggccaggg agccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005763             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6466:13781
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005763
VERSION     KCXD01005763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6466:13781"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..443
     V_segment       89..382
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64245.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       391..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          106 a           95 c          136 g          108 t
ORIGIN      
        1 acatgggagc acagaacaca gaggactcac catgaagttt gggctgaact gggttttcct
       61 tgttgctatt ttaagaggtg tccagtgtga ggtgcagttg gtggagtctg gaggaggctt
      121 ggttcagccg ggggggtccc tgagactctc ctgtgcagct tctggattca ccttcagtag
      181 ttatggcatg cactgggtcc gcctggctcc agggaagggg ctggagtggg tggcagttac
      241 atcgtctgat gaaagtaaga aatactacgg agactctgtg aaggaccgat tcaccatctc
      301 cagagacaat tccaagaaca tactatatct tcaaatgaac aacctgaaat tggaggacac
      361 ggccgtgtac tactgtggga gagatgataa tggggtgatt atcgactact ggggccaggg
      421 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005764             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20727:12695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005764
VERSION     KCXD01005764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20727:12695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64246.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          121 a          140 c          127 g           99 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatgc ctgcactggg ttcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag ttttaatcct atatatggtg aaattttaca
      301 aacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01005765             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12147:14995
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005765
VERSION     KCXD01005765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12147:14995"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64247.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          130 c          136 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atttatggga gtgatagtag taccaaatac aacccctcct tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccggtgttcc ctgaagctga actctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005766             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22352:14008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005766
VERSION     KCXD01005766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22352:14008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64248.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          135 c          144 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatta gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaaa gaccagttct ccctgagtct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc ggcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005767             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12023:14713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005767
VERSION     KCXD01005767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12023:14713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64249.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       406..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          139 c          127 g          106 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtaact actggaactg gatccgccag cccccaggaa agggactgga
      241 gtggattgga tatctctatg gtagtactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccctgaggc tgagctctgt
      361 gaccgccgcg gacaccgccg tttattactg tgcgagatat ggagatgata gtgttcatta
      421 caactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005768             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15706:20310
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005768
VERSION     KCXD01005768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15706:20310"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64250.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          115 c          153 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtcctg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaag taacatatac tacgcagcct ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaaatttgag gacacggccg
      421 tctattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005769             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19190:14908
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005769
VERSION     KCXD01005769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19190:14908"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64251.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       443..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          115 c          148 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttctat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttcttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtgacagtt atatcgtatg
      301 atgaaagtaa gaaatactac gcagactctc tgaaggaccg attcaccatt tccagagaca
      361 attccaagaa cacgctatat cttcaaatga acaacctgca attggaggac acggccgtgt
      421 attactgtgc gagagatgat aatggggtgc ttatcgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005770             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22731:20253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005770
VERSION     KCXD01005770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22731:20253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64252.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          136 c          129 g          107 t
ORIGIN      
        1 acatggggga tgctctctga gagtcaagga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctactggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggc agtatctctg gtgcttatgg gagcaccagt tataacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005771             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15989:8386
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005771
VERSION     KCXD01005771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15989:8386"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64253.1"
                     /translation="CATHGGYSDIWNSLYHGLDSW"
     D_segment       425..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          121 a          147 c          141 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcca ccggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagttaag aagcctgggg cctcagtgat
      181 ggtctcctgc caggtttccg gatacaccgt caccgaaatt tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgct cctgaaaaaa atgagttaat
      301 acacgcagac aagttccagg acagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtggcc tgacatctga ggacacggcc gtgtattact gtgcgaccca
      421 cggagggtat agcgacatct ggaactccct atatcacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005772             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24545:9983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005772
VERSION     KCXD01005772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24545:9983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64254.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          110 a          121 c          159 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattact gtactaggaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005773             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7829:6635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005773
VERSION     KCXD01005773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7829:6635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64255.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          141 c          149 g           97 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgagatcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcca ggtgtccgga tacacgttca gtgaaatctc catgcactgg gtgcgacaga
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggaact gagtagcctg agatctgacg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005774             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9924:16577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005774
VERSION     KCXD01005774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9924:16577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64256.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          146 c          140 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gtaaatggtg aactaataca
      301 cgcagacaac ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga cacggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag cc
//
LOCUS       KCXD01005775             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6311:9905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005775
VERSION     KCXD01005775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6311:9905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64257.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       407..413
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           84 a          138 c          139 g          105 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagttcccag atgggtcctg tcccaggtgc ggctgcagga
      121 gtcgggccca ggacttgtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggttact actggggctg gatccgccgg cccccagggg agggtctgga
      241 gtggattggg tatatcagtg ggagtggtgg gagttccgac tacaagtcct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttc tccctgaagc tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagtc cggggcgtaa ctatccacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005776             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17295:7103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005776
VERSION     KCXD01005776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17295:7103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..483
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64258.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       400..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..483
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           99 a          137 c          138 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggcccctgtc ccagctgcag ttgcaggagt
      121 cgggcccagg actgatgaag ccttcagaga ccctgtccct cagctgcgct gtctctggtg
      181 gctccataag tggtaactgg tggagctgga tccgccagcc cccagggaag ggactggact
      241 ggattggacg tatctctggt actagtgggg acaccaatta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttctc cctgaagctg aactctgtga
      361 ccgccgcgga cgcggccgtg tattattgtg caagagcgga ttacgaggat gattacggtt
      421 atcatttagg atacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005777             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9066:20631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005777
VERSION     KCXD01005777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9066:20631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..470
     V_segment       119..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64259.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       417..422
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          109 a          134 c          136 g           93 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 tgtccagctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaagctctc
      181 ctgcaaggct tctggataca gcttcaacat cgatgccatc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagggat catccctctt gtcggtataa caaactacgc
      301 acagaagttc cagggcagag tctcgattac cgcggacacg tccacaagca cagcctacat
      361 ggaactgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcga tccaagggaa
      421 cagccagttt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005778             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14886:10560
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005778
VERSION     KCXD01005778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14886:10560"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..332
     V_segment       8..250
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <242..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64260.1"
                     /translation="CARGARSDYHSGYYTHFDYW"
     D_segment       271..289
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       290..332
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           75 a           90 c           93 g           76 t
ORIGIN      
        1 acatggggtg aagctctcct gcaaggcttc tggatatacc ttcagcatct ttgccatcag
       61 ttgggtgcga caggcccctg gacaagggct tgagtggatg ggggggatca tccctcttgt
      121 tgatatgaca aactacgcac agaagttcca gggcagagtc acgattaccg cggacacgtc
      181 cacaagcaca gcctacatgg aactgagcag cctgagatct gaggacacgg ccctatatta
      241 ttgtgcgcga ggcgcccggt ctgattatca tagtggttat tacacccact ttgactactg
      301 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005779             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15840:9451
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005779
VERSION     KCXD01005779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15840:9451"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..259
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64261.1"
                     /translation="CARVRGAAAGFFDFW"
     D_segment       269..280
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           74 a           85 c           97 g           72 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg cgcagcctct ggattcagct tcagttactt
       61 ctacatgacc tgggtccgcc agcctccagg gaaggggctg gagtgggtct caggtattaa
      121 cactggtggg gatgacacaa actatgtaga ctccgtgaag ggcagattca ccatctccag
      181 agagaacgcc aagaacacac tgtatcttca aatggacagc ctaagacctg aggacacggc
      241 tgtctattac tgtgcgagag tgagaggggc agcggctggt ttctttgact tctggggcca
      301 aggagtccta gtcaccgtct cctcagcc
//
LOCUS       KCXD01005780             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14197:20147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005780
VERSION     KCXD01005780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14197:20147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64262.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          109 a          120 c          155 g          125 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcccg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcaa attcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtgctagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005781             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14772:11930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005781
VERSION     KCXD01005781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14772:11930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64263.1"
                     /translation="CARDDRGTGFDYW"
     D_segment       439..444
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          117 c          152 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagcg
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatct
      121 taagaggtgc ccagtgtgag gtgcaactgg cggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcaataac tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt gtcagttaca acgaatgatg
      301 gaaatacgaa gtactacgca gactctgtga aagaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt cgaatgaaca acctgagatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgatcgt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005782             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11839:2940
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005782
VERSION     KCXD01005782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11839:2940"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64264.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       438..450
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          119 c          151 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggttcgcc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt cgctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt ttgtcgtctg
      301 atggaggtta caaataccac gcagactcta agaaggaccg attcaccatc tccagagaca
      361 attccaagaa catcctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagaggggaa tacagtaact ctattgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005783             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7485:12127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005783
VERSION     KCXD01005783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7485:12127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64265.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          138 c          127 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005784             400 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17898:8109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005784
VERSION     KCXD01005784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 400)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 400)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17898:8109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    35..398
                     /note="immunoglobulin heavy chain variable region"
     V_region        35..398
     V_segment       35..328
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <320..>367
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64266.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       338..344
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       354..398
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        399..>400
                     /gene="IGHG"
BASE COUNT           74 a           98 c          130 g           98 t
ORIGIN      
        1 acatggggtt gctcttttga aaggtgtcca gtgtgaggtg caactggtgg agtctggggg
       61 cggcctggct tggcctgggg ggtccctgag actctcctgc gcagcctctg gattcagttt
      121 cagttactac tacatgagtt gggtccgcca ggctccaggg aaggggctgg agtggatctc
      181 aggtattaac agtggtgggg gtagcacatt ctatgcagac tccgtggagg gcagattcac
      241 catctccaga gagaacgcca agaacacact gtctcttcac atggacggcc tgagacctga
      301 ggactcggct gtttattact gtgcgagaga tcgacgtgta cagtcgttat cctggttcga
      361 tgtctggggc ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005785             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13455:21923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005785
VERSION     KCXD01005785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13455:21923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64267.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          149 c          133 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtctccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacgt
      301 tccagggcag agtcatcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac acggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gtccttcgat atctggggcc ctggcacccc agtcaccatc tcctcagcc
//
LOCUS       KCXD01005786             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14134:19575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005786
VERSION     KCXD01005786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14134:19575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64268.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          112 a          144 c          133 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaaatgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgcccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01005787             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6151:5699
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005787
VERSION     KCXD01005787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6151:5699"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64269.1"
                     /translation="CARSGDYGYYYDFDYW"
     D_segment       404..422
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          138 c          133 g          103 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcctcct cctgctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcagtaac tcctggaact ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg acgtttctat aatagtggtg ggaacaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcgaca gacacgtcca agaaccagtt ctccctgaag ctgaactctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagatc gggtgattac ggttactatt
      421 acgactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005788             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14255:16942
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005788
VERSION     KCXD01005788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14255:16942"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64270.1"
                     /translation="CATGRIGSSGWSTLFTGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          151 c          148 g           95 t
ORIGIN      
        1 acatgggggc accacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaggc accctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattac ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga gtggctggga gttgttgatc ctgtcaatgc tgaagaaata
      301 cacgcagaga ggttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgagcagtct catatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcggctg gtccaccctc ttcaccggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005789             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:13326:6931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005789
VERSION     KCXD01005789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:13326:6931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..475
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64271.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       403..411
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           97 a          136 c          138 g          106 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctctg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tgagcagtca ctactgcagc tggatccgcc agtccccagg gaagggactg
      241 gagtggattg gacgtatctc tggtagtggt gggagcaccg actacaaccc ctccctcaag
      301 agtcgagtca ccatctcaac agacacgtcc aagaaggaga tctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgagag aagactatgg tggtaattat
      421 tattttaacc ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005790             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20330:13914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005790
VERSION     KCXD01005790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20330:13914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..523
     V_segment       142..434
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64272.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       449..468
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       481..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          113 a          131 c          155 g          126 t
ORIGIN      
        1 acatgggggc tgagagagga gccttagccc tggatttcaa ggcacttcca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggagg cttggtccag
      181 cctggagggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttacgac
      241 atgacctggg tccgccaggc tccgggaaag gggctggaat gggtctcata tattagttac
      301 actggtaaaa ccatatacta ctctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga actctctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtg
      421 tattattgtt ctagagcggc ttacgaacat gatgacggtt actattacgt cggcaggttt
      481 tttgactgct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005791             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12534:19351
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005791
VERSION     KCXD01005791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12534:19351"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64273.1"
                     /translation="CASGPSGTWNDWYFDIW"
     D_segment       424..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          117 a          144 c          135 g           91 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga actgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgactgga tgggaagtgt tgatcctcta tatggtgaaa tgatacacac
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgacc agcctgagat ctgaggacac ggccgtgtat tattgtgcga gtggccctag
      421 cggcacctgg aacgactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01005792             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16188:5860
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005792
VERSION     KCXD01005792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16188:5860"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64274.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       261..266
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           74 a           78 c           96 g           73 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtactttt
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttacatcg
      121 tctgatgaaa gtaagaaata ctacgcagac tctgtgaagg cccgattcac cgtctccaga
      181 gacaattcca agaacatgtt atatcttcaa acggacaacc tgaaattgga agacacggcc
      241 gtgtattact gcgcgagaga tgtctggggg aggggatttg actattgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005793             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8265:7420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005793
VERSION     KCXD01005793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8265:7420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64275.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       451..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          115 c          155 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgagatac agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta gatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tctattactg tgcgagaatg gattgtactg gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005794             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18752:13155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005794
VERSION     KCXD01005794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18752:13155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64276.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          112 a          121 c          146 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcttctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 gagaactcct tgttccttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005795             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18694:3624
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005795
VERSION     KCXD01005795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18694:3624"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64277.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       428..434
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          112 c          145 g          119 t
ORIGIN      
        1 acatggggag aggaacccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttatt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt acagcctctg gattcacctt cagtagctat ggcttacact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg tctgatgaaa
      301 gtaggaaata ctacgcagac tctctgaagg accgattcac catttccaga gacaattcca
      361 agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtgtattatt
      421 gtgcgaggga tgataatggg gtgcttatcg acttctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005796             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23226:5226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005796
VERSION     KCXD01005796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23226:5226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64278.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       434..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..498
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          132 c          149 g          111 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcgaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcaatacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcaggtatt agtagtggtg
      301 gtaccacata ctacgcagac tccgtgaagg gccgattcac catctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgaacagcc tgacaactga ggacacggcc gtatattact
      421 gtgcgaaggg aggtagcagc tctttctact ggtacttcga tatccggggc cctggcaccc
      481 cagtcaccat ctcctcagcc
//
LOCUS       KCXD01005797             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13530:7524
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005797
VERSION     KCXD01005797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13530:7524"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..332
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64279.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       267..283
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..332
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           81 a           82 c           93 g           78 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatatcgtt
      121 tgatggaact aagcaatact acgcagactc tgtgaaggac cgattcacca tttccagaga
      181 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggggg acacggccgt
      241 acattactgt gcgagagtta gtgggcatac agagggtaca gttgaatact ttgactactg
      301 gggccaggga gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005798             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20225:17298
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005798
VERSION     KCXD01005798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20225:17298"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64280.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          121 a          141 c          135 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctgttg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg ggagtgttga tcctcaatat ggtgagatga
      301 tagacgcaga gaaattccag ggcagagtct ccatgaccga ggacacgtct acagacacag
      361 cctacataga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01005799             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12664:14522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005799
VERSION     KCXD01005799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12664:14522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..484
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64281.1"
                     /translation="CAGGPSGIWNGWYFDIW"
     D_segment       418..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>487
                     /gene="IGHG"
BASE COUNT          114 a          142 c          136 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga cttatccatt cactgggtgc gactggcccc
      241 tggaaaaggg cttcagtgga tcggaagtgt tgatcctgca tatggtgaaa tgataaacgc
      301 agagaatttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttaagc agcctgagat ctgaggacac ggccgtgtat tactgtgcgg gtggccctag
      421 cggcatctgg aacggctggt acttcgatat ctggggccct ggcaccccaa tcaccgtctc
      481 ctcaacc
//
LOCUS       KCXD01005800             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:25380:5869
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005800
VERSION     KCXD01005800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:25380:5869"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64282.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggttc agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaatttcaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005801             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14194:19615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005801
VERSION     KCXD01005801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14194:19615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64283.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          117 c          149 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ccattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
      241 gcatgcactg ggtccgccgg gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tacgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgaggggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005802             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9002:10875
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005802
VERSION     KCXD01005802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9002:10875"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64284.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          118 c          150 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttcctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgtagcct ctggattcac gttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtctgtactt tcgtctgatg
      301 gaagtaacaa atactacgca gactctatga aggaccgatt caccatctcc agagacaact
      361 ccaagaacac actatatctt caaatgaata acctgaaact ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005803             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:20805:11981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005803
VERSION     KCXD01005803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:20805:11981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64285.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          109 c          159 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccagggtcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaagtaggac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtgtatgtt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005804             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21020:12088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005804
VERSION     KCXD01005804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21020:12088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64286.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       433..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          145 c          142 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tccccaacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggac ttgttgatcc tgtaaatggt gaactaatac
      301 acgcagacaa gttccagggc agagtcacca tgaccgaaga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg acatctgagg acacggccat ctacttctgt gcgacaggga
      421 ggatcggtac cagtggctgg tccaacctct tcaatggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01005805             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:7706:14617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005805
VERSION     KCXD01005805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:7706:14617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64287.1"
                     /translation="CVRRPFGSDAFDFW"
     D_segment       446..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          114 c          150 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa atttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtcactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgca
      301 tgatgaaaat aagaaatact acgtagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg caattggagg acacggccgt
      421 gtattattgt gtgagacgac cgttcggtag tgatgctttt gatttctggg gccaagggct
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01005806             383 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18298:12021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005806
VERSION     KCXD01005806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 383)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 383)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18298:12021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..381
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..381
     V_segment       12..308
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <300..>350
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64288.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       319..333
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       340..381
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        382..>383
                     /gene="IGHG"
BASE COUNT           81 a           94 c          118 g           90 t
ORIGIN      
        1 acatgggggg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag cctggggggt
       61 ccctgagact ctcctgtgca gcctctggat tcaccttcag tgactactgg atgtactggg
      121 ttcgccagac acctgagcag gggctggaat ggatctcagc tattgatagt gctggtacta
      181 gtaccacata ctatgcagac tccgtgaagg gcagattcac catctccaga gagaacgcca
      241 aaaacacact gtatcttcag atggacagcc tgagaactga ggacacggct gtctattact
      301 gtgcgagagt tccgggccta gtggtattta ctggttcgct tgactactgg ggccagggag
      361 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005807             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12280:16897
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005807
VERSION     KCXD01005807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12280:16897"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64289.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          139 c          149 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggag acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgcgcct ggaaatgggg aaataataca
      301 cgcagataac ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgta tattactgtg cgagcgggac
      421 atttgggacc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcagc gtctcctcag cc
//
LOCUS       KCXD01005808             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24508:18596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005808
VERSION     KCXD01005808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24508:18596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64290.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          120 c          151 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg agccttggtt
      181 cgccctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttttgtcg
      301 tctgatggag gttacaaata ccacgcagac tctaagaagg accgattcac catctccaga
      361 gacaattcca agaacatcct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagagg agaatacagt aactctattg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005809             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20829:15690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005809
VERSION     KCXD01005809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20829:15690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64291.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          111 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gacttgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01005810             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7458:18348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005810
VERSION     KCXD01005810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7458:18348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64292.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       439..444
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          111 a          114 c          155 g          116 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 gggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta ctagtggcat
      241 gcactgggtc cgccaggctc cagggaaggg actggagtgg gtggctgttg aatcgcatga
      301 tggaaataag aaatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaacaac atgctatatc ttcaaatgaa caacctgaaa ttggaggata cggccgtgta
      421 ttactgtgtg agagatgcct acgggggcgg tttggattcc tggggccaag gggtcgtcgt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005811             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19670:8828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005811
VERSION     KCXD01005811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19670:8828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64293.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       447..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          113 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgaa ttcacgttca gtaattttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatctcgaa
      301 tgatgccact aagaaatact acgtggactc tgtgaaggac cgattcacca tctccagaga
      361 caactctaag aaaatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatg cgtttggcag cgggcttgat tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005812             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:14458:2030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005812
VERSION     KCXD01005812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:14458:2030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64294.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          123 c          146 g          130 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc ttctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccgagaa ctccttgttc cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005813             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22665:15441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005813
VERSION     KCXD01005813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22665:15441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64295.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       309..314
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       318..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           86 a           84 c          109 g           83 t
ORIGIN      
        1 acatgggggt gcaactggtg gagtctggag gaggcttggt tcagcctggg gggtccctga
       61 gactctcctg tgcagcctct ggattcacct tcagcacctt tggcatacac tgggtccgcc
      121 aggctccagg gaaggggctg gagtgggtgg cagttatatc gtatgatgaa actaagaaat
      181 actacgcaga ctctgtgagg gaccgattca ccatctccag agacaattcc aaaaacatgg
      241 tatattttca aatgaacaac ctgaaattgg aggacacggc cgtatattac tgtgcgagag
      301 atgtcagggg aacgggattt gacttctggg gccagggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01005814             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6913:2755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005814
VERSION     KCXD01005814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6913:2755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64296.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       436..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          116 c          154 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgtttcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggagtc cctgagactc tcctgtgcag cctctggatt caccttcagt agctctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtgtctgta atttcgtctg
      301 atggaggtaa gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 actccaagaa catactatat cttcaaatga acagcctgaa attggaggac acggccgtgt
      421 atttctgtgt gagagatgcc ttcgggggcg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005815             391 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:5903:17270
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005815
VERSION     KCXD01005815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 391)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 391)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:5903:17270"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..389
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..389
     V_segment       20..313
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>358
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64297.1"
                     /translation="CARGLSPDVFGFLGLGYW"
     D_segment       339..343
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       352..389
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        390..>391
                     /gene="IGHG"
BASE COUNT           82 a           99 c          124 g           86 t
ORIGIN      
        1 acatgggggc gcccactctg aggtccagct ggtgcagtct ggggctgaag tgaagaagcc
       61 tggggcctca gtgaaggtct cctgcaaggt tttcggatac accttcagcg atttatccat
      121 gcactgggtg cgacaggccc ctggaaaagg gcttgagtgg atgggaggtg ttgacactgt
      181 ctctgacgga gtgatatacg cagagaactt ccagggcaga gtcgccatga ccgaggacac
      241 gtctacagac acagcctaca tggaattgag cagcctgaga tctgaggaca cggccgttta
      301 ttactgtgcg agaggtttat caccagacgt cttcggtttc ctcgggcttg gctactgggg
      361 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005816             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16112:7335
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005816
VERSION     KCXD01005816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16112:7335"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..415
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64298.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       419..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           99 a          139 c          135 g          114 t
ORIGIN      
        1 atggggaggg tccagcttac atgggaaatg ctctctgaga gtcatggacc tcctgtgcaa
       61 gaacatgaag cacctgtggt tcttccttct cctggtggca gctcccagat gggtcctgtc
      121 ccaggtgcgg ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct
      181 cacctgcgct gtctctggtg actccatcag cagtagctac tggaactggg tccgccagcc
      241 cccagggaag ggactggaat ggattgggta tatctctggt gcttatggga gcaccaacta
      301 caacccctct ctcaagagtc gagtcaccat ttcactagac acgtccaaga gccacttttc
      361 cctgaggctg agttctgtga ccgccgcgga caccgccgta tattactgtg tgagatatga
      421 ggatgaatcc attaattacc actttgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005817             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12908:14885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005817
VERSION     KCXD01005817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12908:14885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64299.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       442..447
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          114 c          152 g          120 t
ORIGIN      
        1 acatgggggg agagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagagcaca gaggactcac catgaagttt gggctgagct gggttttctt tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtat ttctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggc tggcagttaa atcgtttgat
      301 ggaactaaga tatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtttat
      421 tactgtgtga gagacgccta cgggagcggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005818             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13379:10109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005818
VERSION     KCXD01005818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13379:10109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64300.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       419..425
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          137 c          142 g          101 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagtcccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtaca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga ggtgttgata ttgtatctga tggaatgata
      301 tacgcagaaa acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgcgagaggt
      421 gtgacagcag acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005819             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14223:6481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005819
VERSION     KCXD01005819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14223:6481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..431
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64301.1"
                     /translation="CARARYYHDSGYHWYFDIW"
     D_segment       438..457
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..510
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          124 a          146 c          137 g          105 t
ORIGIN      
        1 acatgggggg gcagagtaca tggggacata acaaccacgt ccctcctcta aagaagcccc
       61 tgggaacaca gctcatcacc atggacttga cctggaggct cctctttgtg gtggcagcag
      121 ctacaggtgc ccagtcccag gtccagctga tgcagtccgg ggctgaggtg aagaagcttg
      181 gggcctcagt gaagctctcc tgcaaggctt ctggatacac cttcaacatc tatgccatca
      241 gttgggtgcg acaggcccct ggacaagggc ttcagtggat gggaggaatc atccctcttg
      301 ttgatctaac aaactacgca caagaattcc agggcagagt cacgattacc gcggacacgt
      361 ccacaaccac tgcctacatg gagctgagca gcctgagatc tgaggacacg gccatatatt
      421 actgtgcgag agcgcgatat taccatgata gtggttacca ctggtacttc gatatctggg
      481 gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01005820             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23679:16054
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005820
VERSION     KCXD01005820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23679:16054"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64302.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          122 a          142 c          134 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggac ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005821             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17438:11961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005821
VERSION     KCXD01005821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17438:11961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64303.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          135 c          129 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc agttgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagttat aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtcccagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggagccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005822             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:27015:6061
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005822
VERSION     KCXD01005822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:27015:6061"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..420
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64304.1"
                     /translation="CAREYCTSDSCAGFFDYW"
     D_segment       421..432
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          117 a          138 c          138 g          105 t
ORIGIN      
        1 acatgggggg catcacaaaa caaccacatc cctcctctaa agaagcccct gggaacacag
       61 ctcatcacca tggactggac ctggaggctc ctctttgtgg tggcagcagc tacaggtgtc
      121 cagtcccagg tccacttggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtttcct gcaaggcttc tggattcacc ctcgacaact atggaatcaa ttgggtgcga
      241 caggcccctg gacaagggct tgagtgggtg ggagtgatca tcccccttgt cggtatagtg
      301 aactacgtag agaccctcca gggcagaggc accataaccg cggacacgtc aacaaacaca
      361 gtctacatgg aactgaacag cctgagatct gacgacacgg ccatctatta ctgtgcgaga
      421 gaatactgta cttctgattc ttgcgccgga ttctttgact actggggcca gggagtcctg
      481 gtcaccgtct cttcagcc
//
LOCUS       KCXD01005823             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17726:4836
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005823
VERSION     KCXD01005823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17726:4836"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..396
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64305.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       403..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           92 a          135 c          130 g          103 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctac aattgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg ctgtctctgg
      181 tggctctatc agcatttact actggaattg gatccgccag gccccaggga agggactgga
      241 ctggattgga catatctatg gtagcggtga tagcaccaac ttcaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagttc tccctgaacc tgaggtctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagcggt cggcggcagc tggactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005824             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15047:17657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005824
VERSION     KCXD01005824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15047:17657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..487
     V_segment       120..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64306.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       423..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>491
                     /gene="IGHG"
BASE COUNT          113 a          140 c          141 g           97 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgaag tgaagaggcc tggggcctca gttaaggtct
      181 cctgcaaggt ttccggatac accttcaccg aaatatccat gcactgggtg cgacaggccc
      241 ccggaaaagg acttgagtgg atgggaagtg ttgatcctgt gtatagtgaa gaaatactcg
      301 cagataattt ccacgacaga gtcaccatga ccgaggacac gtctacaggc acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgtata tttctgtgcg gcgggccttg
      421 gggggtatct agtgcttact gaatacctcg aattctgggg ccagggcgcc ctggtcaccg
      481 tctcctccgc c
//
LOCUS       KCXD01005825             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22848:4900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005825
VERSION     KCXD01005825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22848:4900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64307.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       436..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          124 c          159 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cacccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg cgcagcctgg
      181 ggggtccctg aaactcccct gcgcagcctc tggattcagc ttcagctact tctacatgag
      241 ctgggtccgc caggctccag gaaaggggct ggagtggatc tcagggattg acagtggtgg
      301 gggtgacaca ttctatgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaggaca ctgtatcttc aaatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgcgagg tctactggga gctacagggg atactttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005826             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11081:4797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005826
VERSION     KCXD01005826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11081:4797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64308.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          112 a          115 c          159 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccttgagac tctcctgtac agcctccgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa gggactggag tgggtggcac tgatttcgta
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcaccc tctccagaga
      361 caattccgag aacatcctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttttgt gcgagagttg gagagggtac tggtggtgcg gaggactttg acttctgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005827             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20740:9016
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005827
VERSION     KCXD01005827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20740:9016"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64309.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       443..451
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          112 c          153 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcggttata tcgtttgatg
      301 atagtaagaa atactacgta gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcttac ggtagtggct gggactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005828             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16368:19597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005828
VERSION     KCXD01005828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16368:19597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..410
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64310.1"
                     /translation="CVRERGEDGGAGIPHYFDYW"
     D_segment       435..442
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          143 c          141 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagacgc ctggggcctc agtgaaactc
      181 tcctgcaaga cttctggata cagcttcagc atctatgcca tccattgggt gcgtcaggcc
      241 cctggacaag gccttgagtg gatgggacgg atcgtccctc ttgttggtat gacaaactac
      301 gcacagaagt tccaggacag agtcacactt accgcggaca cgtccacaag gacagcctac
      361 atggaactga gcagcctgag atctgacgac acggccttct attattgtgt acgagagagg
      421 ggcgaagatg ggggagctgg aatcccccac tactttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01005829             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14733:15298
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005829
VERSION     KCXD01005829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14733:15298"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64311.1"
                     /translation="CAREFSPYDYVWSDFYSYYFDYL"
     D_segment       410..416
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           94 a          145 c          135 g          113 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc acaaaagtcg
      301 agtcatcatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actatgtttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005830             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:3913:19863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005830
VERSION     KCXD01005830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:3913:19863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64312.1"
                     /translation="CAREEKFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          112 a          116 c          153 g          122 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc atctggagga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg taacctctgg attcaccttc agtagctatg
      241 gcatgcactg ggcccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagatttac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagag gagaaatttg gctacagttt tgacttctgg ggccagggag
      481 tcctggtcac cgtctcctcg gcc
//
LOCUS       KCXD01005831             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18745:6071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005831
VERSION     KCXD01005831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18745:6071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64313.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       435..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          113 c          157 g          115 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ttttggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttac atcgtctgat
      301 gaaagtaaga aatactacgc agactctgtg aaggcccgat tcaccgtctc cagagacaaa
      361 tccaagaaca tgttatatct tcaaatggac aacctgaaat tggaagacac ggccgtctat
      421 tactgcgcga gagatgtctg ggggagggga tttgactatt ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005832             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22878:12445
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005832
VERSION     KCXD01005832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22878:12445"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..507
     V_segment       127..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64314.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       427..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>513
                     /gene="IGHG"
BASE COUNT          115 a          140 c          147 g          111 t
ORIGIN      
        1 acatggggag catcacataa caaccacgtc cctcctctaa agaagcccct gggaacacag
       61 ctcatcacca tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc
      121 cagtcccagg tccacctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg
      181 aagctctcct gcaagacttc tggatacacc ttcagcatct ctgccatcag ttgggtgcga
      241 caggcccctg gacaagggct tgggtggatg ggagggatca tccctcttgt tggtgtgaca
      301 aactacgaac agaagttcca gggcagagtc acgattaccg cggacacgtc cacgaataca
      361 gtcttcatgg aactgagcag cctgagatct gaggacacgg ccgtctacta ttgtgcgaca
      421 ggggtatatt accaggatga atacggttat ttttatgtcg gcggtgactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01005833             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:25607:10715
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005833
VERSION     KCXD01005833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:25607:10715"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..509
     V_segment       146..438
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64315.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       445..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          110 a          121 c          160 g          120 t
ORIGIN      
        1 acatggggga gctctgagag aggagcctta gccctggatt tcaaggcact tccacctggg
       61 gatcagcact gaacacagag gacccaccat ggagttgggg ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagttggtg gagtctgggg gaggcttggt
      181 ccagcctgga gggtctctga gactctcctg tgtaggctct ggattcagct tcagaagtta
      241 cgaaatgagt tgggtccgcc aggctccggg aaaggggctg gagtgggtct catatattag
      301 tcacactggt gaaaccatat accacgctga ctccgtgaag ggccgattca ccatctccag
      361 agacaacgcc aagaattcgc tgtctctgca aatgagcagc ctgagagccg aggacacggc
      421 cgtgtattac tgtactagaa accggaatac tgtcatgatt gggtggttcg atgtctgggg
      481 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005834             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21719:17432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005834
VERSION     KCXD01005834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21719:17432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64316.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          144 c          137 g           89 t
ORIGIN      
        1 acatggggga cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgaagcag cctggggcct tagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaactgag
      361 cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggcccta ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01005835             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18833:6138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005835
VERSION     KCXD01005835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18833:6138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64317.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       417..421
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          147 c          134 g          100 t
ORIGIN      
        1 acatgggatc acaaaacaac cacatccctc ctctaaagaa gcccctggga gcacagctca
       61 tcaccatgga ctggacctgg aggctcctct ttgtggtggc agcagctgca ggtgtccagt
      121 cccaggtcca cctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaaaa
      181 tttcctgcgg ggcttctgga ttcaccttcg acacccatgg tatcaactgg gtgcgacagg
      241 cccctggaca aggacttcag tggatgggag tgatcatccc ccttattggt atcaccaact
      301 acgcaaagaa ctctcagggc agagtcacac taaccgcgga cacgtccaca aacacagcct
      361 acatggagct gaacagcctg agatttgagg acacggccat ctactactgt gcgagagaac
      421 gctgcacttc tagtgtttgc gccgggttcc ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005836             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:11046:11095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005836
VERSION     KCXD01005836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:11046:11095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64318.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          143 c          129 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctgctgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtggcttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctctggtg ctactgggag taccagctac accccctccc tcaagagtcg
      301 agtcaccatt tcaacaaaca cgtccaagaa ccacttttcc ctgaggctgc actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gcggatgatt acggttatta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005837             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11185:13752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005837
VERSION     KCXD01005837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11185:13752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64319.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       436..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          104 a          124 c          160 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca ggtggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ccattagtgt
      301 tggtggtagt acatattacg cagactccgt gaggggccga ttcaccatct ccagagacaa
      361 ctcagagaac acgctctccc tgcaaatgaa cagcctgaga gctgaggaca cggccgtgta
      421 ttactgtgcg aaaggggata cagctacagt ttattacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005838             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4453:7416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005838
VERSION     KCXD01005838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4453:7416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..403
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64320.1"
                     /translation="CARMPLNSGSYYFPGYVDYW"
     D_segment       419..429
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           89 a          144 c          142 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccggtggc tccttcagca gtggttactg gagctggatc cgccaacccc cagggaaggg
      241 gctggagtgg attgggtata tcggtggtag tagtggttcc acctactaca acccctccct
      301 caagagtcga gtcatcattt caaaagacac gtccaagaag caggtctccc tgagcctgac
      361 ctctgtgacc gccgcggaca cggccgtgta ttattgtgcg agaatgcccc ttaacagcgg
      421 tagttattat ttccccgggt acgttgacta ctggggccag ggcgtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005839             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:26325:13646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005839
VERSION     KCXD01005839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:26325:13646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..433
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64321.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       444..458
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          111 a          123 c          154 g          120 t
ORIGIN      
        1 acatggggct aggagaggag cccagccctg ggattcccag gtgttttcat ttgtgatcag
       61 cactgaacac agaagactca tcatggagtt tggcctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagggtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accatcagta actactggat
      241 gtactgggtt cgccaggcac cagggaaggg gctggagtgg atctcagcca ttaatagtgc
      301 tgaaagtacc acatactatg cagacgccgt gaagggcaga ttcaccatct ccagagacaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagtaccgg gcctagtggt gtttactggt tcccttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005840             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:21631:18313
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005840
VERSION     KCXD01005840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:21631:18313"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64322.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          116 a          143 c          131 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctacac tgggtgcgac
      241 aggctcctgg gaaaggactt gagtggatgg gaggtgttca tcctgaatat ggaaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01005841             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19966:20438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005841
VERSION     KCXD01005841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19966:20438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64323.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          111 c          156 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagt agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgaa tcgcatgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggtggatacg gccatgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005842             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11254:11188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005842
VERSION     KCXD01005842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11254:11188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64324.1"
                     /translation="CAKGETAAVYYGLDSW"
     D_segment       441..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          110 a          134 c          151 g          111 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc agctggtcga gtccgggggc ggcttggcga
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctacg
      241 ccattcactg ggtccgccag gctccaggga agggactgga gtgggtctca gccattagta
      301 gtggtggcag cacattctac gcagcctccg tgaagggccg attcaccatc tccagagaca
      361 attcaaagaa cacgctctcc ctacaaatga acagcctaac aactgaggac acggccatgt
      421 attactgtgc gaaaggagaa acagctgcag tttactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01005843             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14227:19900
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005843
VERSION     KCXD01005843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14227:19900"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..517
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64325.1"
                     /translation="CARERFGGTGVIIYSWVDFW"
     D_segment       451..464
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..517
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          107 a          128 c          163 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtatttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttcttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca acctccggat tcaccttcag tgacttctac
      241 atggactggg tccgccaggc tccagggaag gggctggagt gggtctcacg tattaatcat
      301 gatggtggta gcacatggta cgcagactcc gtgaggggca gattcaccat ctccagagac
      361 aacgccaaga acacactgta tcttcaaata gacagcctga gacctgagga cacagccgtg
      421 tatttctgtg cgagagagcg gtttggggga actggggtga ttatctacag ctgggtcgat
      481 ttctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005844             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9493:11090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005844
VERSION     KCXD01005844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9493:11090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..483
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64326.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       400..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..483
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           99 a          135 c          139 g          112 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcga gaacatgaag tatctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ttgcaggagt
      121 cgggcccagg actgatgaag ccttcagaga ccctgtccct cagctgcgct gtctctggtg
      181 gctccataag tggtaactgg tggagctgga tccgccagcc cccagggaag ggactggact
      241 ggattggacg tatctctggt actagtgggg acaccaatta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttctc cctgaagctg aactctgtga
      361 ccgccgcgga cgcggccgtg tattattgtg caagagcgga ttacgaggat gattacggtt
      421 atcatttagg atacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005845             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14703:9797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005845
VERSION     KCXD01005845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14703:9797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64327.1"
                     /translation="CARDAFGSGLDYW"
     D_segment       449..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          118 c          151 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctctcttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agacttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagatat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatttcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgcttcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc ttaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgctttcggc agcgggcttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005846             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13271:14935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005846
VERSION     KCXD01005846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13271:14935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64328.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          111 c          152 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccaatcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005847             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9697:7917
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005847
VERSION     KCXD01005847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9697:7917"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..505
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64329.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       433..445
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          117 a          143 c          150 g           97 t
ORIGIN      
        1 acatgggggc agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgaga tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gccaggtgtc cggatacacg ttcagtgaaa tctccatgca ctgggtgcga
      241 cagacccctg gaaaagggct tgagtggatg ggatgtgttg ctcctggaaa tggtgaaata
      301 atacacgcag agaacttcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg aactgagtag cctgagatct gacgacacgg ccgtgtatta ctgtgcgaca
      421 gggaggttcg ggagcagcgt ctggtccagc ctcttctacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005848             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21451:16058
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005848
VERSION     KCXD01005848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21451:16058"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64330.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       407..422
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          135 c          131 g          108 t
ORIGIN      
        1 acatggggga atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtggctccat caccaatagt tactggaact ggatccgcca gcccccagga aaggggctgg
      241 agtggattgg gtctatctat ggtggtactg ggagcaccgg ctacaatccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgaag ctgacctctg
      361 tgaccgccgc ggacaccgcc gtttattatt gtgcgagata tgaggatgaa tacagtgact
      421 actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005849             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23673:8297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005849
VERSION     KCXD01005849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23673:8297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64331.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       442..447
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          102 a          127 c          157 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccatt gtgaggcgca cctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctaagac tctcctgtga agcctccggg ttcaccttca gtgaccactg
      241 catgcactgg gtccgccagg cttcagggag ggggctggag tgggtctcag gtattactta
      301 tactggtgtt accacatggt acgcagactc cgtgaggggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgggaggaa ggcggcacgt ggaccttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005850             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22063:16311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005850
VERSION     KCXD01005850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22063:16311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64332.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          119 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccaa gaatatacta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005851             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19994:12865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005851
VERSION     KCXD01005851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19994:12865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64333.1"
                     /translation="CVKGDTAAVYYGLDFW"
     D_segment       438..447
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          103 a          129 c          157 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggcagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggca
      181 gagcctgggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 gctgttcact gggtccgcca ggctccagaa aaggggctgg agtgggtctc agctgttagt
      301 accggtggta ccacatacta ctcagactcc gtgaagggcc gattcaccat ctccagagac
      361 aactcaaaga acacgttctc ccttcaaatg agcagcctga gagctgagga cacggccgtg
      421 tattactgtg tgaaggggga tacagctgca gtctactacg gtttggattt ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005852             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5230:9667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005852
VERSION     KCXD01005852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5230:9667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64334.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       406..414
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          132 c          135 g          114 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctctcagc ggtggttatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggc tatatctatg gtgctagagg gagcaccacc tacaacccgt ccctcaggaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttg tccctgaagt tgagttctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagacag tgctgttatt atgatgactt
      421 tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005853             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12189:10683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005853
VERSION     KCXD01005853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12189:10683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..238
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <232..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64335.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       261..267
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..325
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           78 a           85 c           95 g           69 t
ORIGIN      
        1 acatgggcct gcaaggtttc cggaaacacc ttcaccgaat tatccatgca ctgggtgcga
       61 caggcccctg gaaaagggct tgagtggatg ggatgtgtcg atcctgcaca aggtgaaata
      121 atacacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      181 gccttcatgg aattgagcag cctgacatct gaggacacgg ccgtgtattt ctgtgcgaaa
      241 ggggggttcg gaaccagcgt ctggtccaat ctcttctacg gtttggattc ctggggccaa
      301 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005854             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19630:19667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005854
VERSION     KCXD01005854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19630:19667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    28..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        28..342
     V_segment       28..275
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <267..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64336.1"
                     /translation="CTRSPITAAGVFDFW"
     D_segment       286..295
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..342
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           89 a           96 c           84 g           75 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caatgaagct ctcctgcaag gcttctggat
       61 ataccttcac tgactattac atacactggg tgagacaggc ccctggacaa ggccttgact
      121 gggtaggact gttctcccct tacaatgatt acaaagacta cgctcagaac ttccgggaca
      181 gagtcaccat aactgtggac atgtccacga gcacaggcta catggaactg agcagcctga
      241 gatctgagga cacagccgtg tattactgta cgagaagccc cataacagcg gctggagttt
      301 ttgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005855             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16948:15878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005855
VERSION     KCXD01005855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16948:15878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..390
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64337.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       411..420
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           95 a          144 c          133 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagt agttactggt ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggaa gtactggtag cacctactac accccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccatttctcc ctgaaactga actctgtgac
      361 caccgcggac acggccgtat attactgtgc aaacgtcttg ggcccctggg gcagctggtc
      421 acactacttt gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005856             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20024:18465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005856
VERSION     KCXD01005856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20024:18465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64338.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          117 a          112 c          154 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgat ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tatgatgtaa gtaagaaata ctacgcagac gctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgggagaga tgataatggg gtgcttatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005857             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7952:18339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005857
VERSION     KCXD01005857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7952:18339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64339.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       407..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          134 c          137 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctccggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctctatcag cagtagttac tgcagctgga tccgccagac cccagggaag ggactggagt
      241 ggattggcta tatatatggg agtgatagta gcaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagtgctc cctgaaggtg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagttcggg tatagaagtg gttgcctaca
      421 gcattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005858             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22720:20533
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005858
VERSION     KCXD01005858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22720:20533"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64340.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          114 a          143 c          129 g           91 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccaag cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt gttcatcctg aatatggtaa agtagactac
      301 acacagaagt tccgagacag agtcaccatc accgcggaca tgtcgacaga gacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgactt ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005859             331 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21086:20684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005859
VERSION     KCXD01005859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 331)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 331)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21086:20684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    11..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        11..329
     V_segment       11..243
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <236..>298
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64341.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       264..275
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>331
                     /gene="IGHG"
BASE COUNT           72 a           86 c           98 g           75 t
ORIGIN      
        1 acatgggctc tcctgcaagg ccgctggata cattttcagt acctctgcca tcagttggct
       61 gcgacaggcc cctggacaag ggcttgagtg gatggggggg atcatgcctc ttgttggtag
      121 aacaaactac gcacagaggt tccagggcag agtcacgatt accgcggaca cgtccacaag
      181 gacagccaac atggagctga gcagcctgac atctgaggac acggccgtgt attactgtgc
      241 gagcggtggt ttccaggatg agaacggtta ctattttcca gactattttg acttttgggg
      301 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005860             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19713:19515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005860
VERSION     KCXD01005860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19713:19515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64342.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       400..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          134 c          131 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctacaat tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagt atttactact ggaattggat ccgccaggcc ccagggaagg gactggactg
      241 gattggacat atctatggta gcggtggtag caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagttctcc ctgaacctga ggtctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagcggtcgg cggcagctgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005861             277 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8096:8157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005861
VERSION     KCXD01005861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 277)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 277)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8096:8157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..275
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..275
     V_segment       8..209
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <206..>244
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64343.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       220..225
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..275
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        276..>277
                     /gene="IGHG"
BASE COUNT           63 a           71 c           85 g           58 t
ORIGIN      
        1 acatgggagt gaccactgca tacactgggt ccgccaggct tcagggaagg ggctggagtg
       61 ggtctcaggt attacttata ctggtgttac cacatggtac gcagactccg tgaggggcag
      121 attcaccatc tccagagaga acaccaagaa cacactgtat cttcaaatgg acagcctgag
      181 agctgaggac acggctgtct atttctgtgt ggcaggaagg cggcacgtgg accttgacta
      241 ctggggccag ggagtcctgg tcgccgtctc ctcagcc
//
LOCUS       KCXD01005862             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13967:10416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005862
VERSION     KCXD01005862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13967:10416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64344.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       426..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          119 a          144 c          137 g           95 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cattctgagg tccagctggt gcaatctggg gctgaggtga tgcagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctttata tggtgaaatg
      301 atacacacag aacagttcca gggcagagtc accctgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgagt
      421 ggccctagcg gcagctggaa cgactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01005863             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10535:15503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005863
VERSION     KCXD01005863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10535:15503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64345.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       430..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          114 a          142 c          144 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg acacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggctggga ggtgttgatc ttgtatatga tgaaataata
      301 cacgcagaga agttccaagg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgct cactgaatac ctcgagttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01005864             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:15980:4228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005864
VERSION     KCXD01005864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:15980:4228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64346.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       419..427
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          113 a          140 c          145 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaagtgagg aagcctgggg tctcagtaaa
      181 ggtctcctgc aaggtttccg gaaacaccat caccgaatta tccgtgcact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg gggtgttgat cccgtctatg gtgaaataag
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtctattact gtgcgcgagg
      421 atattgtcat ggtagttact gttcctcggg tcttgtctcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005865             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8247:15206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005865
VERSION     KCXD01005865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8247:15206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64347.1"
                     /translation="CARWEAASFDYW"
     D_segment       405..409
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           84 a          131 c          138 g          106 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agaacatgaa gcgcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccgtca gcggtggtta tggctggagc tggatccgcc aggccccagg gaagggactg
      241 gagtggattg ggagtatcta tggtcatagt ggtagcaccc gctacaatcc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgacctct
      361 gtgaccgccg cggacacggc cgtgtatttc tgtgcgagat gggaagctgc ctcttttgac
      421 tactggggtc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005866             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11625:7479
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005866
VERSION     KCXD01005866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11625:7479"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64348.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       446..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          112 a          115 c          151 g          129 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggaatctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctttgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggactggg tatcaggtat taacattggc
      301 ggtgacacgt actacccaga ctctgtgaag ggtcgattca ctatgtccag agacaatgcc
      361 aagaactccg tgtatcttca aatgaacagc ctgagtgttg aggacactgc tgtgtatttt
      421 tgtgcaaggg ggatagataa ctaccactat agtgatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005867             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:21793:17046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005867
VERSION     KCXD01005867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:21793:17046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64349.1"
                     /translation="CAREFSPYDYFWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           95 a          145 c          133 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actatttttg
      421 gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005868             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11711:8914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005868
VERSION     KCXD01005868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11711:8914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64350.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       262..274
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           77 a           75 c           95 g           74 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagtctctg gattcacctt cagtagcttt
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgacatcg
      121 tatgatggaa gttggaagta ctacggagac tctgtgaagg accgattcac catctccaga
      181 gacaattcca agaacatgct atatcttcag atgaacaacc tgaaattgga ggacacggcc
      241 gtatattact gtgcgagagg ggaatacagt aactctattg actactgggg ccagggagtc
      301 ctggtcaccg tctcctcagt c
//
LOCUS       KCXD01005869             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4612:9523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005869
VERSION     KCXD01005869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4612:9523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64351.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       439..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          108 a          118 c          150 g          120 t
ORIGIN      
        1 ggggagctct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta cctctggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg ctgacagtta tatcgtatga
      301 tgaaactaag aaatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atggtgtatc ttcaaatgaa caacctgaca tttgaggacg cggccgtgta
      421 ttactgtgcg agagattctt acggtcgagg ctttgattcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005870             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13280:7127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005870
VERSION     KCXD01005870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13280:7127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..498
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64352.1"
                     /translation="CVRDAFGSGCDYW"
     D_segment       449..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>501
                     /gene="IGHG"
BASE COUNT          118 a          115 c          150 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgaactgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg agggttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt caatacctat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 aatgatgaaa ctaaaaaata ctacgcagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct atatcttcaa atggacaacc tgaaattgga ggactcggcc
      421 gtgtattact gtgtgagaga cgcatttggc agcggctgtg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcaac c
//
LOCUS       KCXD01005871             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:16812:19818
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005871
VERSION     KCXD01005871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:16812:19818"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64353.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          130 c          138 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggttctgtcc cagctgcagc tgcaggagtc
      121 gggcccaggg ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact ggagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atccatggga gtgatagtag taccaagtac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa tcaatgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 tattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01005872             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:25476:10993
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005872
VERSION     KCXD01005872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:25476:10993"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64354.1"
                     /translation="CARDEGEISGYRFGYW"
     D_segment       453..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          111 c          162 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaaa ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcatc atctctagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gagattggag gacacggcca
      421 tgtattactg tgcgagggat gagggggaga ttagtgggta ccgatttggc tactggggcc
      481 agggagtccg ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005873             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:25839:7385
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005873
VERSION     KCXD01005873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:25839:7385"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64355.1"
                     /translation="CANALSGGLDYW"
     D_segment       444..449
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          101 a          126 c          162 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggtact
      241 ggatgaactg ggtccgccag gcgccaggga aggggctgga gtgggtctca gctattacta
      301 gtggtggcga cagcacatac tacgctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaactctaa gaatacgctc tccctgcaaa tgaacagcct tagagcggag gacacggccg
      421 tgtattactg tgcgaacgcg ttaagtgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005874             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10025:15472
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005874
VERSION     KCXD01005874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10025:15472"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64356.1"
                     /translation="CARDTSFTGRYDYW"
     D_segment       400..404
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           93 a          138 c          128 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag ccatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggaatc
      121 gggcccagga gtggtgaagc cttcggggac cctgtccctc acgtgcgctg tctctggtgg
      181 ctccatcagt attagttata ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattgga tacatctatg gtagtagtac gaccaccaac tacaacccct ccctcaaaag
      301 tcgagtcacc atttcacaag acacgtccaa gaaccagttc tccttgaggc tgaactctgt
      361 gaccgccgcg gacacggccg tatatttctg tgcgcgagat acttccttta ccggccggta
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005875             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16543:8402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005875
VERSION     KCXD01005875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16543:8402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..420
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <412..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64357.1"
                     /translation="CARWEAASFDYW"
     D_segment       426..430
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           91 a          136 c          144 g          109 t
ORIGIN      
        1 acatggggag ggtccagctc acatgggaaa tgttctctga gagtcacgga catcctgtgt
       61 aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc agctgcagga gtcgggccca gcagtggtga agcctttgga gaccctgtcc
      181 ctcacctgcg ctgtctctgg tggctccgtc agcggtggtt atggctggag ctggatccgc
      241 caggccccag ggaagggact ggagtggatt gggagtatct atggtcatag tggtagcacc
      301 cgctacaatc cctccctcaa gagtcgagtc accatttcaa aagacacgtc caagaaccag
      361 ttctccctga agctgacctc tgtgaccgcc gcggacacgg ccgtgtattt ctgtgcgaga
      421 tgggaagctg cctcttttga ctactggggt cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005876             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14821:4189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005876
VERSION     KCXD01005876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14821:4189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64358.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          112 a          142 c          132 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt
      181 ctcctgcaag atttccggat acaccttcac cgaattatcc atacactggg tgcggcaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 tagcctgaca tctgaggaca cggccgtgta ttactgtgcg actggcccta gcggcacctg
      421 gaacgcctgg tacctcgata tctggggccc tggcacctca atcaccatct cctcagcc
//
LOCUS       KCXD01005877             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17408:5673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005877
VERSION     KCXD01005877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17408:5673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64359.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       435..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..499
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          104 a          139 c          148 g          110 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagcactgg aagtccacag tgttccattc ggtgatcacc
       61 actgaacaca gaggactcac catggagtct gggctgagct gggttttcct tcttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg ggggcggctt ggcgaagcct
      181 gggggatccc tgagactctc ctgtgcagcc tctggattca ccttcaacac ctatgctatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtactgct
      301 ggtagcacat actacgcaga ctccgtgaag ggccgcttca ccgtctccag agacaactca
      361 aagaacacgc tctccctcca agtgaacagc ctgagacctg aggacacggc cgtgtattac
      421 tgtgcgaaag gaggtagcag ctctttctac tggtacttcg atatccgggg ccctggcacc
      481 ccagtcacca tctcctcagc c
//
LOCUS       KCXD01005878             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:11234:18513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005878
VERSION     KCXD01005878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:11234:18513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64360.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       441..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          119 c          151 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagt actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg catctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
      241 ggcatgcact gggtccgcca ggctccagga aaggggctgg actgggtggc agttatgtcg
      301 tctgatggaa ataacaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct ctatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagaga tgtctttggc ggggggcttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005879             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10454:21612
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005879
VERSION     KCXD01005879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10454:21612"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64361.1"
                     /translation="CARDLNTALSYNSLDVW"
     D_segment       401..407
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..467
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          145 c          124 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc aataactact ggacctggat ccgccaatcc ccagggaagg gactggagtg
      241 gattggacgt atctctggtt atggtgactt caccgcctac accccctccc tcgagagtcg
      301 agtctccatt tcaaaagact cgtccaagag ccaattctcc ctgaaactga actctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagatctc aatacagccc tttcgtacaa
      421 ctcattggat gtctggggcc ggggacttct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005880             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:18082:8629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005880
VERSION     KCXD01005880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:18082:8629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64362.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       424..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          143 c          145 g          102 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatccacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgct cctctatatg gtgaaatgat
      301 gctcgcagac aactgccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga cgacacggcc gtgtattact gtgcgcgtgg
      421 gcctattaca atttttggcg tacttattac ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005881             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13183:8570
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005881
VERSION     KCXD01005881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13183:8570"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..462
     V_segment       84..375
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64363.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       398..404
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..462
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT          107 a          123 c          139 g           95 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
       61 cagcagctac aggcgcccac tctgaggtcc aactggtgca gtctggggct gaaatgaaga
      121 agcctggggc ctcagttagg gtctcctgca aggtttccgg aaacaccttc accgaattat
      181 ccatgcactg ggtgcgacag gcccctggaa aagggcttga gtggatggga tgtgtcgatc
      241 ctgcacaagg tgaaataata cacgcagaga aattccaggg cagagtcacc atgaccgagg
      301 acacgtctac agacacagcc ttcatggaat tgagcagcct gacatctgag gacacggccg
      361 tgtatttctg tgcgaaaggg gggttcggaa ccagcgtctg gtccaatctc ttctacggtt
      421 tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01005882             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4581:19874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005882
VERSION     KCXD01005882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4581:19874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..260
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64364.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       266..272
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       278..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           77 a           82 c           90 g           74 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gtacagcctc tggattcacc ttcagtacct
       61 ctggcatgca ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat
      121 cgtatgatga aactaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca
      181 gagacaattc caagaacatg gtatatcttc aaatgaacaa cctgaaattg gaggacgcgg
      241 ccgtgtatta ctgtgcgaga gattcttacg gtcgaggctt tgactcctgg ggccagggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005883             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19229:13841
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005883
VERSION     KCXD01005883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19229:13841"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..447
     V_segment       69..362
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <354..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64365.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       366..385
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..447
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           91 a          120 c          138 g          100 t
ORIGIN      
        1 acatggggac catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg
       61 cccagtctca ggtccagctg gtgcagtccg gggctgagat ggagaagcct ggggcctcag
      121 tgaagctctc ctgtaaggct tctggataca ccttcagcat ctatgtcatc agttgggtgc
      181 gacaggcccc tggacaaggg cttgagtgga tgggaggcat cttccctctt gttggtacaa
      241 caaactacgc acagaagttc cagggcagag tcacgattac cgcggacacg tccacaagca
      301 cagcctacat ggacctgagc agcctgggat ctggggacac ggccgtgtat tattgtgcga
      361 gaggttactg tactggtagt ggttgtaacc ttacattcaa ccggctcgat gtctggggcc
      421 cgggagtccc ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005884             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8651:20594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005884
VERSION     KCXD01005884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8651:20594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..498
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64366.1"
                     /translation="CATGVYYQDEYGSFYIGGDFDFW"
     D_segment       414..435
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          138 c          143 g          111 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggcccctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca atccggggct gatgtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcctctgg atacaccttc agcatctctg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttgg gtggatggga gggatcatcc ctcttgttgg tatgacaaac tacgaacaga
      301 agttccacgg cagagtcacg attaccgcgg acacgtccac gaatacagtc ttcatggagc
      361 tgagcagcct gagatctgag gacacggccg tctattattg tgcgacaggg gtatattacc
      421 aggatgaata cggttctttt tatatcggcg gtgactttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005885             351 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5900:7795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005885
VERSION     KCXD01005885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 351)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 351)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5900:7795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..349
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..349
     V_segment       6..285
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <277..>318
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64367.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       295..300
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..349
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        350..>351
                     /gene="IGHG"
BASE COUNT           77 a           86 c          109 g           79 t
ORIGIN      
        1 acatgggggt ctgggggcgg cttggcaaag cctggggggt ccctgagact ctcctgtgca
       61 gcctctggat tcaccttcag tagacactgg atgaactggg tccgccagcc tccaggaaag
      121 gggcttgagt gggtctcaac tattaatagt ggtggggata acacatatta cgcggactcc
      181 gtgaagggcc gattcaccat ctccagagac aattcaaaga acacgctcct cctgcaaatg
      241 aacagcctga gagtggagga cacggccgtg tattactgtg ttcaagggga aatttttgga
      301 gtgggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01005886             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:18396:16578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005886
VERSION     KCXD01005886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:18396:16578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64368.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       436..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          125 c          159 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca ggtggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag ccattagtgt
      301 tggtggtagt acatactacg cagactccgt gaggggccga ttcaccatct ccagagacaa
      361 ctcagagaac acgctctccc tacaaatgaa cagcctgaga gctgaggaca cggccgtgta
      421 ttactgtgcg aaaggggata cagctacagt ttattacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01005887             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14112:15877
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005887
VERSION     KCXD01005887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14112:15877"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..388
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64369.1"
                     /translation="CMKYRYHSGTYNDYW"
     D_segment       405..413
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           96 a          135 c          134 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcgcag tctccggtga
      181 ctccttcagc agttactggt ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag gtcaatggtg atagtgggag cgccaactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaggaa gcaggtctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccgtat attactgtat gaaatatcgc tatcatagtg gtacttataa
      421 cgactactgg ggcctgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005888             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21743:3274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005888
VERSION     KCXD01005888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21743:3274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..465
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64370.1"
                     /translation="CARYEDDSGYYYFDSW"
     D_segment       409..421
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>469
                     /gene="IGHG"
BASE COUNT           90 a          133 c          130 g          116 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacttga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agttgcagga
      121 gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcatctgcg ctgtctctgg
      181 tgcctccatc accagtagct tctggagctg gatccgacag cccccaggga agggactgga
      241 gtggattggc tatatctatg gtagtactgg gagtagcagt tccaatccct ccctcaagag
      301 tcgagtcacc atttcaacgg acacgtccaa gaaccagttt tccctgaaac tgagctctgt
      361 gaccgccgcg gacaccgcct tttatttctg tgcgagatat gaagatgata gtggttatta
      421 ctactttgac tcctggggcc agggagtcct ggtcaccgtc tcctcggcc
//
LOCUS       KCXD01005889             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17443:4436
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005889
VERSION     KCXD01005889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17443:4436"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64371.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..410
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           85 a          136 c          140 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga cttgtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggggctggat ccgccagccc ccaggggagg ggctggagtg
      241 gattgggtat atcagtggga gtggtgggag taccgactac aagtcctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005890             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12466:8674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005890
VERSION     KCXD01005890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12466:8674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..453
     V_segment       93..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <378..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64372.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       406..412
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           82 a          136 c          140 g           97 t
ORIGIN      
        1 acatggggag agtcacggac atcctgtgca agaacatgaa gcacctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccagctgaa gctgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt gtctccatca
      181 gcactcactc ctggagctgg gtccgccagc ccccagggaa ggtactggag tggattggac
      241 gtatctctgg tagtggtggg cgcacggact acaatccctc cctcaagagt cgagtcacct
      301 tttcaacaga cacgtccagg aaccagttgt ccctgaggct gacgtctgtg accgccgcgg
      361 acacggccgt gtattactgt gcgagagttg aaagcgcctg gtccgtgggg tgggattact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005891             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:25845:5207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005891
VERSION     KCXD01005891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:25845:5207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..348
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..348
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64373.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       293..298
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       307..348
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        349..>350
                     /gene="IGHG"
BASE COUNT           80 a           80 c          108 g           82 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc agccgggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcagcttc agtggctttg gcatgcactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttatatcgt atgatgaaac taagaaatat tacgcagact
      181 ctgtgaagga ccgattcacc gtctccagag acaattccaa gaacatgcta tattttcaaa
      241 tgaacaacct gaaattggaa gacacggccg tgtattactg tgcgagagat gtctatggca
      301 ggggacttga ctactggggc ctgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005892             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:6072:9228
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005892
VERSION     KCXD01005892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:6072:9228"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64374.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       424..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          120 a          145 c          132 g           96 t
ORIGIN      
        1 acatggggaa catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gattcacctt caccgattta tccatacact ggatacgaca
      241 ggcccctgga aaagggcttc agtggatggg aagtgttgat cctgcatatg gtgaaatgat
      301 aaacgcagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 cttcatggaa ttgagcagcc tgaaatctga cgacacggcc gtatattact gtgcgagtgg
      421 ccctagcggc acctggatcg actggtcctt cgatgtctgg ggccctggca ccccaatcac
      481 cgtctcctca acc
//
LOCUS       KCXD01005893             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17142:11931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005893
VERSION     KCXD01005893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17142:11931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..496
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64375.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       436..443
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>502
                     /gene="IGHG"
BASE COUNT          120 a          141 c          142 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttcgtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgtaaa gtttccggat acacggtcat cgatttatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gaacatggtg aagtaatata
      301 cgcagacaac ttccagggca gagtcgccat gagcgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cgacccacgg
      421 aggatataga ggcatctgga actccctata ctacggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctccccag cc
//
LOCUS       KCXD01005894             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11829:18363
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005894
VERSION     KCXD01005894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11829:18363"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64376.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       440..449
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          110 a          116 c          150 g          116 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagtaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcaactggtg gagtctgggg gaggcttggt tcggccgggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcaatagttt tggcatccac
      241 tgggtccgcc aggctccagg gaagggcctg gagtgggtgt cagttatatc gtctgatgaa
      301 agtaagaaat attacgcaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaacatgg tatatcttca agtgaacaac ctgaagctgg aggacacggc cctctattac
      421 tgtgcgagag acgcatatgg cagcggctgt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01005895             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9528:18664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005895
VERSION     KCXD01005895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9528:18664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64377.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          112 a          117 c          148 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca atcactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggat tgggtggcag ttatgtcgtt
      301 tgatgaaaat gtgaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtattactgt gcgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01005896             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18924:7443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005896
VERSION     KCXD01005896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18924:7443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64378.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       309..314
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       318..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           84 a           85 c          110 g           83 t
ORIGIN      
        1 acatgggggt acagctggtg gagtctggag gagacttggt tcaccctggg gggtccctga
       61 gactctcctg tgcagcctct ggattcacct tcagtaactt tggcatacac tgggtccgcc
      121 agggtccagg gaaggggctg gagtgggtgg cagttatatc gtatgatgaa actaggacat
      181 actacgcaga ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatga
      241 tatttcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattac tgtgcgagag
      301 atgtcagggg aacggggttt gactactggg gccagggagt cctggtcccc gtctcctcag
      361 cc
//
LOCUS       KCXD01005897             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22944:12273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005897
VERSION     KCXD01005897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22944:12273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64379.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          122 c          145 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttccc
      301 atgatgaaac taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacaaacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005898             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:18226:14885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005898
VERSION     KCXD01005898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:18226:14885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64380.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          119 c          158 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga gttcccaggc gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg tggctctttt
      121 gaaaggagtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagccggg
      181 ggggtccctg agactctcct gcgtagtctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgg caggctccag ggaaggggct ggagtggatc tcaagtattg acagtggtgg
      301 gactaccaca aattatgcag actccgtgag gggcagcttc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgaaagcc gaggacacgg ctgtctatta
      421 ttgtgcgaga gcgcgcgggg tgattattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005899             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18685:10785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005899
VERSION     KCXD01005899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18685:10785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64381.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          111 a          115 c          154 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagtctctgg attcaccttc aggaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ttgatggaat taagagttat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa gaacatgcta aatcttcaaa tgaacgacct gaaattggag gacacggccg
      421 tgtattactg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01005900             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15783:10537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005900
VERSION     KCXD01005900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15783:10537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64382.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       401..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           83 a          136 c          139 g          103 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtgtt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagtc accagggaag gggctggagt
      241 ggattgggtt tttcggtggt agtggtggga acacctacta caagtcgtcc ctccagagtc
      301 gagtcaccat ttcaaccgac acgtccaaga accagttctc cctgacactg acctctgtga
      361 ccgccgcgga cacggccctc tattactgtg cgagggggaa tatagcagcg actggcattg
      421 attactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005901             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17547:8393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005901
VERSION     KCXD01005901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17547:8393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64383.1"
                     /translation="CTKGRSGGVWPNSFDYW"
     D_segment       430..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          135 c          143 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggccccagg aaaagggctt gagtggatgg gaagtgttga tcctgtatat ggtgaaataa
      301 ttgtcgcaga caatttccag gacagagtca ccatgaccga ggacacgtct accgacacag
      361 cctacatgga gctgagcagc ctggaatctg acgacacggc catgtattac tgtacgaaag
      421 ggaggagtgg tggtgtctgg ccgaactcct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005902             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:2917:10194
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005902
VERSION     KCXD01005902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:2917:10194"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..494
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64384.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          109 a          118 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cgttcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
      241 gcatgcactg ggtccgccag actccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatagaaa taatatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatgctg tatcttcaaa tgaacaacct acagttggag gacacggccg
      421 tgtattcctg tgtgcgagat gcctacggta ccgggttgga ttcctggggc caaggcgtcg
      481 tcgtcatcgt ctccccagcc
//
LOCUS       KCXD01005903             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17446:17928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005903
VERSION     KCXD01005903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17446:17928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64385.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       409..414
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           97 a          137 c          127 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtcca gttgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcggttacta ctggaactgg atccgccaac caccagggaa ggggctggag
      241 tggattgggt ttatcgctgg tagtagtggg accaccaact acaacccctc cctcaagagt
      301 cgagtcacca tctcaacaga cacgtccaag aaccagttct ccctgaacct gaactctgtg
      361 accgccgcgg acacggccat gtattactgt gcgagaaata gatttatggg tattagagtt
      421 cttgcctact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005904             389 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7288:8530
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005904
VERSION     KCXD01005904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7288:8530"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..387
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..387
     V_segment       8..299
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <291..>356
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64386.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       309..315
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       334..387
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        388..>389
                     /gene="IGHG"
BASE COUNT           83 a           86 c          123 g           97 t
ORIGIN      
        1 acatgggggt gcagctggtg gagtctgggg gaggcttggt aaagcctggg gggtccctga
       61 gactctcttg tgtagtctct ggattctcct tcagtaacta tgttatgcat tgggtccgcc
      121 aggctccagg aaagggtctg gagtgggtct cacttattag tggaagtggt ggtaccacag
      181 actacgcaga ctctgtgaag ggccgattca ccctctccag agacaacgcc aaggaatcgc
      241 tttttctgca aatgaacagc ctaagagccg aggacacggc cgtgtattac tgtgctagag
      301 gcggggaaat agtggattca gagattattg aggattacta cggtttggat ttctggggcc
      361 aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01005905             325 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:17855:8527
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005905
VERSION     KCXD01005905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 325)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 325)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:17855:8527"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..323
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..323
     V_segment       8..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>292
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64387.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       264..269
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..323
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        324..>325
                     /gene="IGHG"
BASE COUNT           81 a           77 c           91 g           76 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg tgcagcctct ggattcacgt tcagtaacta
       61 tggaatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc
      121 gtacgatgaa aataagaaat actacgcaga ctctctgaag gaccgattca ccatctccag
      181 agacaattcc aagaacatgc tttatcttca aatgaacaac ctgaaattgg aggacacggc
      241 cgtttattac tgtgcgagga ggccctggag tgcagatgct tttgatttct ggggccaagg
      301 actcagggtc accgtctctt cagcc
//
LOCUS       KCXD01005906             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6726:14321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005906
VERSION     KCXD01005906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6726:14321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64388.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          127 c          158 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtcttaacag
      301 tggtggggat accacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaact ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005907             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:12883:5077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005907
VERSION     KCXD01005907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:12883:5077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64389.1"
                     /translation="CVRLDCSGGVCYFDYW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          109 c          157 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agatggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ctgggtgaca gttatatcgt
      301 atgatggaag tacgaagtac tatgtagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagatta gactgtagtg gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01005908             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:14726:8465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005908
VERSION     KCXD01005908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:14726:8465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..395
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64390.1"
                     /translation="CTTWTTGYNYYFAYFDSW"
     D_segment       403..411
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          138 c          131 g          112 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga gcggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc gacactaaca ggtggagttg gatccgccag tccccaggga agggactgga
      241 gtggattgga tacatcgatg gttctagtac gcgcaccgac tatattccct ccctcaaaag
      301 tcgagtcacc atttcaaaag acacgtccag gaaccagttc tccttgaggc tgaattctgt
      361 gaccgccgcg gacacggccg tgtattactg tacgacttgg acgactggtt acaattatta
      421 tttcgcctac tttgactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005909             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15401:20537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005909
VERSION     KCXD01005909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15401:20537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64391.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       447..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          106 a          123 c          156 g          124 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttgtcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcgggggc tggagtggat ctcagctatt gatagtgctg
      301 gtactagtac cacataccat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctcgtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005910             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22517:7668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005910
VERSION     KCXD01005910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22517:7668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    77..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        77..437
     V_segment       77..366
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <359..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64392.1"
                     /translation="CVKSGSASLHWYLEIW"
     D_segment       368..375
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       387..437
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT           90 a          117 c          135 g           97 t
ORIGIN      
        1 acatgggaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
       61 aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg cggaacccgg
      121 gggatccctg agactctcct gtgcagcctc tggattcacc ttcagtacct atgctatgca
      181 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcagctatta gtagtggtgg
      241 aaccacatcc tacgcagact ccgtgaaggg ccgattcacc gtctccagag acaactcaaa
      301 aaacacgctg tccctgcaga tgaacagcct gagagctgag gacacggccg tgtattactg
      361 tgtgaagagt gggagtgcca gccttcactg gtacctcgaa atctggggcc ctggcacccc
      421 aatcaccatc tcctcagcc
//
LOCUS       KCXD01005911             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14377:18397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005911
VERSION     KCXD01005911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14377:18397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64393.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       434..442
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          115 a          111 c          154 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaactaagaa gtactacgga gactctgtga aagaccgatt caccatctcc agagacaatt
      361 ccaagaacag gctatatctt caaatgaaca acctgaaatt ggaggacacg gcagtatatt
      421 actgtgcgag agatgatagt ggggtgatca tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01005912             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13571:18675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005912
VERSION     KCXD01005912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13571:18675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64394.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       408..415
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..468
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          151 c          122 g          103 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcacggaca tcctgtacaa gaacatgcgg tatctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcac ctgcaggagt
      121 cgggcccagg actggggaag ccttcagaaa ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag tcgtaactgg tggagttgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtcttggaa gtaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tatttctgtg cgagacattc agaccccgca actactagct
      421 ggtacttcga tctctggggc cccggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01005913             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:17951:7126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005913
VERSION     KCXD01005913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:17951:7126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..429
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64395.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       436..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..500
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          108 a          133 c          149 g          112 t
ORIGIN      
        1 acatggggct gggagaggag cccagcactg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcgaagcc
      181 tgggggatcc ctgagactct cctgtgcagc ctctggattc accttcaata cctatgctat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtctcaggta ttagtagtgg
      301 tggtaccaca tactacgcag actccgtgaa gggccgattc accatctcca gagacaactc
      361 aaagaacacg ctctccctgc aaatgaacag cctgacaact gaggacacgg ccgtatatta
      421 ctgtgcgaag ggaggtagca gctctttcta ctggtacttc gatatccggg gccctggcac
      481 cccagtcacc atctcctcag cc
//
LOCUS       KCXD01005914             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9428:3728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005914
VERSION     KCXD01005914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9428:3728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64396.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       429..439
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          114 a          142 c          143 g           95 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga cacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggctgggag gtgttgatct tgtatatgat gaaataatac
      301 acgcagagaa gttccaaggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattactgt gcggcgggcc
      421 ttgggggata tttactgctc actgaatacc tcgagttctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01005915             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11824:9391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005915
VERSION     KCXD01005915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11824:9391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64397.1"
                     /translation="CAAQIHSGGWSGRFDVW"
     D_segment       432..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..491
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          135 c          146 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcctggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatatgcctt cacagaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggc aggtgttgat tctgaatatg gtgaaatgat
      301 tgacgcggag acgttccagg acagagtcac catgaccgac gacacgtcta cagatacagc
      361 ctacatggag ttgagtatcc tgagatctga ggacacggcc gtgtattact gtgcggccca
      421 aattcatagt ggcggctggt ctgggcggtt cgatgtctgg ggcccgggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01005916             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20667:8718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005916
VERSION     KCXD01005916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20667:8718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64398.1"
                     /translation="CARRPWDADAFDFW"
     D_segment       442..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>503
                     /gene="IGHG"
BASE COUNT          114 a          117 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag cctccaggga aggggctgca gtgggtggca gttatatcgt
      301 acgatgaaga taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtattactg tgcgaggagg ccctgggatg cagatgcttt tgatttctgg ggccaagggc
      481 tcagggtcac cgtctcttta gcc
//
LOCUS       KCXD01005917             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12818:11843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005917
VERSION     KCXD01005917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12818:11843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64399.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          120 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgagact aagaaatact acgcagactc tgtgaaggac cgattcagca tctccagaga
      361 caactccaag aatatgctat atcttcaact gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005918             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10681:18905
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005918
VERSION     KCXD01005918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10681:18905"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..519
     V_segment       138..430
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64400.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       445..464
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..519
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          112 a          129 c          154 g          126 t
ORIGIN      
        1 acatggggag agaggagcct tagccctgga tttcaaggca cttccacctg gggatcagca
       61 ctgaacacag aggacccacc atggagttgg ggctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggaggcttg gtccagcctg
      181 gagggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tacgacatga
      241 cctgggtccg ccaggctccg ggaaaggggc tggagtgggt ctcatatatt agttacactg
      301 gtaaaaccat atactactct gactccgtga agggccgatt caccatctcc agagacaacg
      361 tcaagaactc tctgtctctg caaatgagca gcctgagagc cgaggacacg gccgtgtatt
      421 attgttctag agcggcttac gaacatgatg acggttacta ttacgtcggc aggttttttg
      481 actgctgggg ccagggagcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005919             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:23521:2295
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005919
VERSION     KCXD01005919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:23521:2295"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64401.1"
                     /translation="CVTVGSYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          116 a          142 c          130 g           94 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgcca
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttcc ggatacacct taaccgacca ctacctacac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtattct tcctgagtat ggtaaagttg
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggttccta ccattacttt gactactggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01005920             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12303:16212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005920
VERSION     KCXD01005920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12303:16212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64402.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          118 c          150 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa attctacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgatgct ggaggacacg gccgtctatt
      421 actgtgcgag agacgcatat ggcagcggct gtgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005921             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6657:12635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005921
VERSION     KCXD01005921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6657:12635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64403.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          146 c          135 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cgttgatcct gcatatggtg agtttacacc
      301 cggagagaag ctccagggca gagtcaccat gaccgaagac acgtctatag acacagccta
      361 catggagctg agcagcctga attctgacga cacggccgtc tattactgtg ctgccgggta
      421 tagcggcagc tggaaccact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01005922             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20639:8681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005922
VERSION     KCXD01005922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20639:8681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..484
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64404.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       401..422
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..484
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          135 c          138 g          113 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgcg agaacatgaa gtatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gttgcaggag
      121 tcgggcccag gactgatgaa gccttcagag accctgtccc tcagctgcgc tgtctctggt
      181 ggctccataa gtggtaactg gtggagctgg atccgccagc ccccagggaa gggactggac
      241 tggattggac gtatctctgg tactagtggg gacaccaatt acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccacttct ccctgaagct gaactctgtg
      361 accgccgcgg acgcggccgt gtattattgt gcaagagcgg attacgagga tgattacggt
      421 tatcatttag gatacaactg gttcgatgtc tggggcccgg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01005923             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8574:6759
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005923
VERSION     KCXD01005923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8574:6759"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64405.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          113 c          150 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcttgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaaataacaa atactacgca gactctgtga aggaccgatt caccatttct agagacaatt
      361 ccatgaacat gctatttctt caaatgaaca acctgaactt ggacgacacg gccgtctatt
      421 actgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005924             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21884:9968
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005924
VERSION     KCXD01005924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21884:9968"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64406.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          114 c          158 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagag tctcctgtgt agcctctgga ttcaccttca atagctatgg
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tgggtgggaa ttgtttcctt
      301 tgatggaact aagagatact acgcagactc tgtgagggac cgagtcacca tttccagaga
      361 caactccaag aatatgctat atcttcaaat ggacaacctg aaattcgaag acacggccgt
      421 gtattacagt acgagagtag actgtagtgg tggtgtctgc tactttgacc actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005925             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16726:12607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005925
VERSION     KCXD01005925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16726:12607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64407.1"
                     /translation="CARDRFMGIGALGYW"
     D_segment       399..403
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           88 a          132 c          145 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgtaa gagcatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagc agtggtgaag ccttcggaga ccctgtccct cacctgcgaa gtctctggtg
      181 gctccatcag cggtggttat ggctggacct ggatccgcca ggccccaggg aagggactgg
      241 agtgggttgg gagaatgtat ggtagcagtg gtagcaccta ctacaacccc tccctcaagg
      301 gtcgagtcac catttcaaaa gacacgtcca agatccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtttattatt gtgcgagaga taggttcatg ggcatagggg
      421 ctctcggcta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005926             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13427:3318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005926
VERSION     KCXD01005926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13427:3318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64408.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       438..450
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          113 c          148 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagt tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcaga aactatggca
      241 tgcactgggt ccgccaggcc ccagggaagg ggctggattg ggtggcagtt atgtcgtttg
      301 atgaaaatgt gaaattctac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa tatgctatat cttcaaatga acaacctgaa attggaggac acggccctgt
      421 attactgtgc gagaggggaa tacagtaact ctattgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005927             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22160:5625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005927
VERSION     KCXD01005927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22160:5625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..515
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64409.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       458..465
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          104 a          139 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggttca actggtggag tctggaggag acttggtcca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttcctatgg
      241 catgacctgg gtccgccagg ctccagggaa ggggctggag tgggtctcat acattagtat
      301 tggtggtggt accacatcct acgcagactc cgtgaagggc cgattcaccg tctccagaga
      361 caactcagag aaaacgctct ccctgcaaat gaacagcctg agacctgacg acacggccgt
      421 gtattactgt gcgtcgaatc tacgtggtaa cacctacact tactggcggt cctttgactc
      481 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005928             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:4148:10820
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005928
VERSION     KCXD01005928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:4148:10820"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64410.1"
                     /translation="CARTTSRGLVFDFW"
     D_segment       398..402
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..459
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           90 a          139 c          129 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcac ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccttcag cagttactgg tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggcttgggga gatcaatggt aatagcggaa ccaccaacta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaaaagac gcgtccaaga atcagttctc cctgaaccta aattctgtga
      361 ccgccgcgga cacggccgtc tatttctgtg cgaggaccac ctcccgggga cttgtttttg
      421 atttctgggg ccaagggctc agggtcaccg tctcttcagc c
//
LOCUS       KCXD01005929             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10175:4935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005929
VERSION     KCXD01005929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10175:4935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64411.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       420..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          110 a          146 c          135 g           92 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgaag tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 agggtctcct gcaggatttc cggatacacc ttcaccgaat tatccataca ctgggtgcgg
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctctgta tggtgaaatg
      301 aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc ctacttggaa
      361 ctgagcggcc tgacttctga ggacacggcc gtgtattact gtgcgactgg ccctaccggc
      421 acctggaacg cctggtacct cgatatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01005930             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:20110:16846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005930
VERSION     KCXD01005930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:20110:16846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64412.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       436..447
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          111 a          115 c          153 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccattgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactgtc ctgtgcagcc tctggattca ccttcattaa ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggt ctggagtggg tggcagttat gtcgcatgat
      301 ggaactaaga aattctacgc agactctgtg aaggaccgat tcaccatctc cagggacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgagat tggaggacgc ggccgtgtat
      421 tactgtgcga gaggagacta cggtaacagc cttgactact ggggccaggg agtcctgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01005931             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22137:14787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005931
VERSION     KCXD01005931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22137:14787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..484
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64413.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       423..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          103 a          140 c          144 g           99 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgat gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggatt cgccttcaga atgtatgccc tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gctgggaggg atcgtccctc ttgttggaac aacaaactcc
      301 gcacagaagt tccaggacag agtcacgatt accgcggaca cgtccacaag cacagtctac
      361 atggagctga gcagcctgag atctgacgac acggccgtgt attactgtgc gagaggcctg
      421 ggtagcagcg cccactttgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01005932             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23211:10613
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005932
VERSION     KCXD01005932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23211:10613"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64414.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          123 c          153 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagca cacagaggac tcaccatgaa gtttggactg acctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctctgc ggcctctgga ttcaccttca gtacctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgaa
      301 tgatgaaagt aacaaatact acgcagactc tgtgaagggc cgattcagca tctccagaga
      361 caattcgaag aacatgctat atcttcacat gaacaccctg aaattggacg acacggccgt
      421 ctattactgt gcgacagatg cgtttggtag cgggattgac cactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005933             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14484:11136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005933
VERSION     KCXD01005933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14484:11136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..497
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64415.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       417..439
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          111 a          137 c          146 g          109 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccacctggt gcagtccggg gctgaggtga agaggcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggatacacc ttcagcatct ctgccatcag ttgggtgcga caggcccctg
      241 gacaaggact tgggtggatg ggagggatca tccctcttgt tggtatgaca aactacgaac
      301 agaagttcca gggcagagtc acgattaccg cggacacgtc cacgaataca gtcttcatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtctacta ttgtgcgaca ggggtatatt
      421 accaggatga atacggttat ttttatgtcg gcggtgactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01005934             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18660:10522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005934
VERSION     KCXD01005934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18660:10522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..397
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64416.1"
                     /translation="CTRGNIAATGIDYW"
     D_segment       401..408
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           88 a          132 c          138 g          106 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg ggaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gtccccaggg aaggggctgg
      241 agtggattgg gtatatcggt ggtagtaatg ggaacatctt ctataacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgaat ctgatctctg
      361 tgtccgccgc ggacacggcc gtgtattact gtacgagggg gaatattgca gcgactggca
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005935             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21614:9195
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005935
VERSION     KCXD01005935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21614:9195"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..468
     V_segment       84..375
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64417.1"
                     /translation="CATGIYYQDEYGSFSIGGDFDSW"
     D_segment       384..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           98 a          126 c          141 g          105 t
ORIGIN      
        1 acatgggggg aacacagctc atcaccatgg acttgacctg gaggctcctc tttgtggtgg
       61 cagcagctac aggtgcccag tcccaggtcc acctggtgca gtccggggct gaggtgaaga
      121 agcctggggc ctcagtgaag ctctcctgca aggcctctgg atacaccttc agcatctctg
      181 ccatcagttg ggtgcgacag gcccctggac aagggcttgg gtggatggga gggatcatcc
      241 ctcttgttgg tatgacaaac tacgaacaga acttccaggg cagagtcacg attaccgcgg
      301 acacgtccac gaatacagtc ttcatggagc tgagcggcct gagatctgag gacacggccg
      361 tctattattg tgcgacaggg atatattacc aggatgaata cggttctttt tctatcggcg
      421 gtgactttga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005936             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23656:16622
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005936
VERSION     KCXD01005936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23656:16622"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..400
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64418.1"
                     /translation="CAKKYRGSYFYSHFDYW"
     D_segment       410..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          100 a          131 c          133 g          113 t
ORIGIN      
        1 acatggggat gctgtctgag agtcagggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcagctg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccttcac ctgcgctgtc
      181 tctggtggct ctatcagcga ttactcctgg agctggatcc gccagacctc agggaaggga
      241 ctggagtgga ttggagatat tgatgataat attgggggca tcaagtacaa atcctccctc
      301 aggagtcgag tcaccatttc aaaagacacg tccaagaatc agttgtccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtctat tactgtgcga aaaagtatcg tggtagttat
      421 ttctactccc actttgacta ctggggccag ggaatcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005937             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:22206:8607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005937
VERSION     KCXD01005937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:22206:8607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64419.1"
                     /translation="CAGGPSGIWNGWYFDIW"
     D_segment       418..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          113 a          142 c          137 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga cttatccatt cactgggtgc gactggcccc
      241 tggaaaaggg cttcagtgga tcggaagtgt tgatcctgca tatggtgaaa tgataaacgc
      301 agagaatttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttaagc agcctgagat ctgaggacac ggccgtgtat tactgtgcgg gtggccctag
      421 cggcatctgg aacggctggt acttcgatat ctggggccct ggcaccccaa tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01005938             528 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:20780:5955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005938
VERSION     KCXD01005938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:20780:5955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..526
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..526
     V_segment       145..438
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>495
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64420.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       452..471
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       484..526
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        527..>528
                     /gene="IGHG"
BASE COUNT          112 a          132 c          157 g          127 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg caactggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtccctgag actctcctgt gcagcctctg gattcacctt cggtagttac
      241 gacatgacct gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 tacactggta aaaccatata ctactctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaactctct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattatt gttctagagc ggcttacgaa catgatgacg gttactatta cgtcggcagg
      481 ttttttgact gctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005939             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4616:11267
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005939
VERSION     KCXD01005939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4616:11267"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64421.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          117 a          139 c          150 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgcct
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtaa
      181 aggtctcctg ccaggtttcc ggagacacct tcagtgaaat gtccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgttgc tcctggaaat ggggaaataa
      301 tacacgcaga taacttccag ggcagagtca ccatgaccga ggacacgtct atagacacag
      361 cctacatgga gctgagtagc ctgagatctg aggacacggc cgtatattac tgtgcgagcg
      421 ggacatttgg gaccagcgtc tggtccagcc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt cagcgtctcc tcagcc
//
LOCUS       KCXD01005940             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15701:3865
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005940
VERSION     KCXD01005940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15701:3865"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..480
     V_segment       106..413
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64422.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       420..429
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>486
                     /gene="IGHG"
BASE COUNT           88 a          145 c          139 g          114 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcacctgcag
      121 gagtcgggcc caggactggt gaagccttcg gagaccctgt ctgtcacctg cgctgtctct
      181 ggtggctcta tcagcagtac caactggagc tggatccgcc aggccccagg gaagggactg
      241 gagtggattg gctgtatctt tggtggtggt atctttggtg gtggaagtaa cacctactac
      301 agcccctccc tcaagagtcg agtcaccctg tcagtagacg cgtccaaggc ccagctctcc
      361 ctgaagctga cgtctgtgac caccgcggac acggccgtct atttctgtgc gagcgctgat
      421 agtggttatc ctccctactt ctttgacatc tggggccagg gagtcctggt caccgtctcc
      481 ccagcc
//
LOCUS       KCXD01005941             372 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22522:16423
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005941
VERSION     KCXD01005941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 372)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 372)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22522:16423"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..370
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..370
     V_segment       10..303
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <295..>339
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64423.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       304..308
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       324..370
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        371..>372
                     /gene="IGHG"
BASE COUNT           79 a           93 c          121 g           79 t
ORIGIN      
        1 acatggggtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc gggggggtcc
       61 ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat gaactgggtc
      121 cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg tggggatagc
      181 acatactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa cgccaagaac
      241 acactgtatc ttcatatgga cagcctgaga actgaggaca cggctgtcta ttactgtgcc
      301 agagtggtgg gtggtgccgc aggatacttc gacttctggg gccagggcgt cctggtcacc
      361 gtctcctcag cc
//
LOCUS       KCXD01005942             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17014:12238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005942
VERSION     KCXD01005942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17014:12238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64424.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          109 a          118 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagacact
      241 ggatgaactg ggtccgccag cctccaggaa aggggcttga gtgggtctca actattaata
      301 gtggtgggga taacacatat tacgcggact ccgtgaaggg ccgattcacc atctccagag
      361 acaattcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattactg tgttcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005943             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15195:15190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005943
VERSION     KCXD01005943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15195:15190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64425.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       436..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          126 c          156 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcaacttcaa ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtggggata gcacctacta tgcggactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga aaactgacga cacggctgtc
      421 tattactgtg cgagagtggt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01005944             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:17555:17638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005944
VERSION     KCXD01005944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:17555:17638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64426.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          116 c          150 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagaaactat
      241 ggcctgcact gggtccgcca ggccccaggg aaggggctgg attgggtggc agttatgtcg
      301 tttgatgaaa atgtgaaatt ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 ctgtattact gtgcgagagg ggaatacagt aactctattg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01005945             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6606:10045
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005945
VERSION     KCXD01005945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6606:10045"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..490
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64427.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          113 a          114 c          145 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtttctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgca aactctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagaacat actttatctt caaatgaaca acttgaaatt ggaggacacg gccgtctact
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc gcc
//
LOCUS       KCXD01005946             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12936:10458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005946
VERSION     KCXD01005946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12936:10458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..396
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64428.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       403..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           93 a          135 c          129 g          103 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccaa atgggtcctg tcccagctac aattgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg ctgtctctgg
      181 tggctctatc agcatttact actggaattg gatccgccag gccccaggga agggactgga
      241 ctggattgga catatctatg gtagcggtga tagcaccaac ttcaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagttc tccctgaacc tgaggtctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagcggt cggcggcagc tggactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005947             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5814:18438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005947
VERSION     KCXD01005947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5814:18438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64429.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          110 a          121 c          154 g          130 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgagc aggggctgga atggatctca gctattgata
      301 gtgctggtac tagtaccaca tactatgcag actccgtgaa gggtagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005948             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:21037:15182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005948
VERSION     KCXD01005948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:21037:15182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64430.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          111 c          155 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc aggagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatat tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005949             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:11827:17998
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005949
VERSION     KCXD01005949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:11827:17998"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64431.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          113 c          153 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaattc tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005950             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:23105:5857
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005950
VERSION     KCXD01005950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:23105:5857"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64432.1"
                     /translation="CVRDSSWYNWDQDFDYW"
     D_segment       408..418
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          100 a          131 c          138 g          103 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgaagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtca ctcaaatgcg ctgtctctgg
      181 tggctccatc accgggaact actggagttg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtaccactg atagtggtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcagcag acacgtccaa gaaccagttc tccctggagt tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattattg tgtgagagat agtagttggt ataactggga
      421 ccaagacttt gactattggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005951             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:16473:9748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005951
VERSION     KCXD01005951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:16473:9748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64433.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          145 c          133 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaatta tcattgcact gggtgcgcca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgtggac cctgcatatg gtgaaatgat
      301 acacacagag atattccagg gcagaatcac catgaccgag gacacgtcaa cagacacagc
      361 ctacatggag ctaagcagcc tgagatctga ggacacggcc gtttattact gtgcgatatc
      421 atccagcggc acctggctat tctggtactt cgatgtctgg ggccctggct ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01005952             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14179:13691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005952
VERSION     KCXD01005952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14179:13691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64434.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       400..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          136 c          130 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctacaat tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcaac atttactact ggaattggat ccgccaggcc ccagggaagg gactggactg
      241 gattggacat atctatggta gcggtggtag caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtggaca cgtccaagaa ccacttctcc ctgaacctga ggtctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagcggtcgg cggcagctgg actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005953             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15355:14143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005953
VERSION     KCXD01005953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15355:14143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64435.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaca ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga agacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctactttaag aggtgtccag tgtgacgtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatat tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tgtatttctg tgtgagagat gttaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005954             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:12472:9162
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005954
VERSION     KCXD01005954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:12472:9162"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..506
     V_segment       128..420
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64436.1"
                     /translation="CARGDCTDTDCSSAGGAFDFW"
     D_segment       426..433
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          109 a          140 c          152 g          107 t
ORIGIN      
        1 acatggggga gcatcacata acaaccacgt ccctcctcta tagaagcccc tgggaacaca
       61 gctcatcacc atggacttga cctggaggct cctctttgtg gtggcagcag ctacaggtgc
      121 ccagtcccag gtccagctgg tgcagtccgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaagctctcc tgcaaggctt ctggatacac gttcagcatc tatgccatca gttgggtgcg
      241 acaggcccct ggacaagggc ttgagtggat gggagggatc atccctcttg ttgatataac
      301 aaactacgca cagaggttcc agggcagagt cacgatttcc gcggacacgt ccacaagcac
      361 agcctacatg gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag
      421 gggagattgt actgatactg actgctcttc cgcggggggc gcctttgatt tctggggcca
      481 agggctcagg gtcaccgtct cttcagcc
//
LOCUS       KCXD01005955             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:15428:12368
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005955
VERSION     KCXD01005955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:15428:12368"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..483
     V_segment       105..404
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64437.1"
                     /translation="CARHGGFYSATDKSTFDNW"
     D_segment       416..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          100 a          136 c          142 g          107 t
ORIGIN      
        1 acatggggga atgctccctg agagtcatgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagtcttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gttactccat caacagtggt tactactact ggggctggat ccgtcagccc ccagggaagg
      241 ggctggagtg gattgggtat ataggtggta gtactgggag cgcctactac aaccccgccc
      301 tcaagagtcg agttgccatt tcaaaagaca cgtccaagaa ccagttctcc ctgaagctga
      361 ggtctgtgac cgccgcggac acggccgtgt atcactgtgc gagacatgga ggtttctata
      421 gtgcgactga caagtcaaca tttgacaact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01005956             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14370:17559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005956
VERSION     KCXD01005956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14370:17559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64438.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       448..454
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..521
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          118 a          125 c          157 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagcact gaacacaaga gactcaccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcaggctct ggattcacct tcagtgacta
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaaatct tacaattacg cgacagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaaga acaccctaca tctgcaaatg agcagcctga aaatcgagga
      421 cacggccgtg tattactgtg ctagagggga tataccggct atagaggcct actacggttt
      481 ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01005957             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:25934:11103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005957
VERSION     KCXD01005957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:25934:11103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64439.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       421..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          102 a          141 c          134 g          112 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa agctctctga gagtcatgga cctcctgtgc
       61 aagaacatga agcacctgtg gttcttcctt ctcctggtgg cagttcccag atgggtcctg
      121 tcccaggtgc agctacagga gtcgggccca ggactggtga agccttcgga gaccctgtcc
      181 ctcacctgcg ctgtctctgg tgactccatc ggcaatagct actggaactg gatccgccag
      241 cccccaggga agggtctgga gtggattggg tatatctctg gtgcttatgg gagcaccagc
      301 tacaacccct ccctcaagag tcgagtcacc atttcaacag acacgtccaa gaaccacttt
      361 tccctgaggc tgagttctgt gaccgccgcg gacaccgccg tgtattactg tgtgagatat
      421 gaggatgaat ccattaacta ccactttgac tactggggcc agggagtcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01005958             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19767:6379
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005958
VERSION     KCXD01005958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19767:6379"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64440.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       428..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          123 c          149 g          105 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcggccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacagtgtca ccgaattatc gattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgtaaaaggt gaagaaattc
      301 acggagagga gttccaggac agagtcacca tgaccgagga cccgtctaca gacacagcct
      361 acatggagtt gagcaacctg agatctgagg acacggccgt gtattattgt gcgagtgggt
      421 ttagtgtctg gttatttaac gacgttttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01005959             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9915:11463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005959
VERSION     KCXD01005959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9915:11463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64441.1"
                     /translation="CARWSAANFDYW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           91 a          137 c          133 g           99 t
ORIGIN      
        1 acatggggaa agttctctga gagtcacgga cctcctgggc aagaacatga agcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc aacagtggtt atggctggag ctgggtccgc cagcccccag ggaagggtcc
      241 ggagtggatt gggtgtctct atgatagtag tggcaacacg tactacaacc cctccctcaa
      301 gagtcgcgtc accatttcaa aagacacgtc caagaaccag ttctccctga acctgaggtc
      361 tatgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005960             333 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24946:13012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005960
VERSION     KCXD01005960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 333)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 333)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24946:13012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..331
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..331
     V_segment       7..250
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <247..>300
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64442.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       266..273
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       287..331
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        332..>333
                     /gene="IGHG"
BASE COUNT           79 a           86 c           88 g           80 t
ORIGIN      
        1 acatgggggg cgtccctgaa gctctcctgt gcagcctctg agttcacctt cagtgactat
       61 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      121 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      181 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      241 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      301 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01005961             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21110:17646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005961
VERSION     KCXD01005961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21110:17646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..296
     V_segment       8..226
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64443.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       236..242
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       252..296
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           67 a           76 c           87 g           68 t
ORIGIN      
        1 acatggggga ttcagcttca gttactactt catgagttgg gtccgccagg ctccagggaa
       61 ggggctggag tggatctcag gtattaccag tggtggggat aacacatact ctgcagactc
      121 cgtgaagggc agattcacca tctccagaga gaacgccaag accacactgt atcttcacat
      181 ggacagcctg agagctgagg acacggctgt ctattactgt gcaagagatc gacgtgtaca
      241 gtcgttatcc tggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01005962             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:10632:11087
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005962
VERSION     KCXD01005962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:10632:11087"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64444.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       440..444
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          109 c          156 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cctcagtaac tatggcatac
      241 actgggtccg ccaggctcca ggggaggggc tggagtgggt ggcagttata tcgtatgatg
      301 gaagtaagaa atattacgca gactctgtga aggaccgatt caccatttcc agtgacagtt
      361 ccaagaacat ggcatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgtgag agatgcgttt ggttccggtt tggattcctg gggcctgggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005963             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:27741:8910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005963
VERSION     KCXD01005963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:27741:8910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64445.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          103 a          116 c          164 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcacagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctcaggtgtt aatagtggtg
      301 gggatagcac atactacgca gactccgtga agggccgatt caccatgtcc agagacaatt
      361 caaagaacac tctctccctg caaatgaaca gcctgagagc ggcggacacg gccgtgtatt
      421 attgtgtgca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01005964             545 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17256:7874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005964
VERSION     KCXD01005964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 545)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 545)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17256:7874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    171..543
                     /note="immunoglobulin heavy chain variable region"
     V_region        171..543
     V_segment       171..461
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <456..>512
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64446.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       470..484
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       502..543
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        544..>545
                     /gene="IGHG"
BASE COUNT          122 a          153 c          155 g          115 t
ORIGIN      
        1 acatgggggc actggtgtct gccgaggtaa atacagatct gtccttgtcc agagagcatc
       61 acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc accatggact
      121 ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct gaggtccagc
      181 tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc tcctgcaagg
      241 tttccggatc caccttcacc gaattatcca tacactgggt gcgacaggcc cctggaaaag
      301 ggcttgagtg gatgggaggt gttgctcctc tatatggtga aatgatgcac gcagacaact
      361 tccagggcag agtcaccttg accgaggaca cgtctacaga cacagcctac atggagctga
      421 gcagcctgag atctgacgac acggccgtgt attactgtgc gcgtgggcct attacaattt
      481 ttggcgtact tattacgggg cttgactatt ggggccaggg agtcctggtc accgtctcct
      541 cagcc
//
LOCUS       KCXD01005965             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14693:9016
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005965
VERSION     KCXD01005965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14693:9016"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64447.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          113 c          155 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact agtggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggctgttgaa tcgcatgatg
      301 gaaataagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaacaacat gctatatctt caaatgaaca acctgaaatt ggaggatacg gccgtgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01005966             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:19724:6060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005966
VERSION     KCXD01005966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:19724:6060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64448.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          122 c          148 g          118 t
ORIGIN      
        1 acatggggaa ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaaa taacctatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagat tcatatggca gcggctccga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005967             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18648:8168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005967
VERSION     KCXD01005967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18648:8168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64449.1"
                     /translation="CAIGPSGTWNGWSFDVW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           99 a          144 c          140 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgtatatggt gaaatggtgt
      301 tccagggcgg ggtcaccatg accgaggaca cgtctacaga cacagcctac ttggagctca
      361 acagcctgag ctctgaagac acggccgtgt actactgtgc gattggccct agcggcacct
      421 ggaacggctg gtccttcgat gtctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01005968             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6749:12307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005968
VERSION     KCXD01005968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6749:12307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64450.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       444..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          112 c          159 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtagt
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg agtgggtggc tgttgaatcg
      301 catgatggaa ataagaaata ctatgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggatacggcc
      421 gtgtattact gtgtgagaga tgcctacggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01005969             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:25897:11503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005969
VERSION     KCXD01005969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:25897:11503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64451.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       408..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          141 c          135 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtatcgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccaa atgcgtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcaacttct actggaactg gatccgccag accccaggga aggggctgga
      241 gtggattggg tgtatcagtg gtgatagtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtccac atttcgacag acacgtccaa gaaacagttc tccctgaaga tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagac ccccggtggc agctggaact
      421 cctcttcttt gactattggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005970             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17519:16435
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005970
VERSION     KCXD01005970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17519:16435"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..497
     V_segment       134..427
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64452.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       437..443
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..497
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          118 c          153 g          118 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc gatcagcaca
       61 aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa
      121 aggtgtccag tgtgaggtga agctggtgga gtctgggggc ggcttggcaa agcctggggg
      181 gtccctgaga ctctcctgcg cagcctctgg attcagcttc aattattact acatgagctg
      241 ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaata gtggtgggga
      301 aagcacatac tctgcagact ccgtgaaggg cagattcacc atctccagag agaacgccaa
      361 gaacacgcta tatcttgaaa tggacagcct gagaactgag gacacggctg tctattattg
      421 tgtgagagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc cgggagccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005971             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22441:6221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005971
VERSION     KCXD01005971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22441:6221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64453.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       440..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          119 c          151 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc atctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggaa aggggctgga ctgggtggca gttatgtcgt
      301 ctgatggaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtctttggcg gggggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005972             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5429:14565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005972
VERSION     KCXD01005972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5429:14565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64454.1"
                     /translation="CAIGPSGSWNDWSLDIW"
     D_segment       417..428
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          140 c          136 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaacttca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga aacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgtatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaattga
      361 gcagcctgag atctgaggac acggccgtgt attactgtgc gattggcccc agtggcagct
      421 ggaacgactg gtccctcgac atctggggac ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01005973             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5831:6442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005973
VERSION     KCXD01005973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5831:6442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64455.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          121 a          143 c          143 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaaatgaa gaagcctggg gcctcagtta
      181 gggtctcctg caaggtttcc ggaaacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgtcga tcctgcacaa ggtgaaataa
      301 tacacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 ccttcatgga attgagcagc ctgacatctg aggacacggc cgtgtatttc tgtgcgaaag
      421 gggggttcgg aaccagcgtc tggtccaatc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01005974             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:13028:5738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005974
VERSION     KCXD01005974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:13028:5738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..484
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64456.1"
                     /translation="CATSPYYEDENVFYPYNWFDVW"
     D_segment       402..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..484
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           97 a          144 c          136 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gtttctgtgg
       61 ttcttcctcc tcctggtggc aactcccaga tgggtcctgt cccagctaca gctgcgggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcagctgcgc tgtctctggt
      181 gactccatca gtaggaactg gtggacctgg atccgacagc ccccagggag gggactggag
      241 tgggttggac gtatctctgg aagtagtggg agcaccatct ataatccctc cctcaagagt
      301 cgagtcgcca tttcaacaga cacgtccaag aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt atattactgt gcgaccagcc cgtattacga ggatgagaac
      421 gttttctacc cctacaactg gttcgatgtc tggggcccgg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01005975             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6206:15731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005975
VERSION     KCXD01005975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6206:15731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64457.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          115 a          114 c          154 g          116 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaact aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 ctattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01005976             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:15866:10221
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005976
VERSION     KCXD01005976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:15866:10221"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64458.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          115 a          122 c          146 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccaagaa ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005977             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:26286:20068
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005977
VERSION     KCXD01005977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:26286:20068"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64459.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          110 a          119 c          155 g          121 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcacaaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcaatt attactacat
      241 gagctgggtc ctccaggctc cagggaaggg gctggagtgg atctcaggta ttaatagtgg
      301 tggggaaagc acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acgctatatc ttgaaatgga cagcctgaga actgaggaca cggctgtcta
      421 ttattgtgtg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01005978             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15888:19943
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005978
VERSION     KCXD01005978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15888:19943"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..330
     V_segment       6..253
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <246..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64460.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       271..279
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           76 a           81 c           92 g           83 t
ORIGIN      
        1 acatgggggc gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
       61 acatgcactg ggttcgccag gctccaggga agggtctgga ctgggtatca ggtattaaca
      121 ttggcggtga cacgtactac ccagactctg tgaagggtcg attcactatg tccagagaca
      181 atgccaagaa ctccgtgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      241 atttttgtgc aagggggata gataactacc actatagtga tacggacttt gactactggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005979             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14360:4226
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005979
VERSION     KCXD01005979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14360:4226"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64461.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       426..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          146 c          143 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgattt atccattcac tgggtgcgac
      241 aggcccctgg aaaagggctt cagtggatgg gaggtgttga tcctggacat agtgaaatga
      301 tacacgcaga caacttccag ggcagagtcg ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgaccc
      421 acggagggta tagaggcatc tggaactccc tatactacgg tttcgattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01005980             287 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8121:9852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005980
VERSION     KCXD01005980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8121:9852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..285
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..285
     V_segment       6..224
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <216..>254
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64462.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       235..243
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..285
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        286..>287
                     /gene="IGHG"
BASE COUNT           71 a           74 c           76 g           66 t
ORIGIN      
        1 acatgggatt caccttcagt acttttggca tccactgggt ccgccaggct ccagggaagg
       61 ggctggagtg ggtggcagtt atatcgtctg atggaaataa cctatactac gcagactctc
      121 tgaaggaccg attcaccatc tccagagaca attccaagaa catggtgtat cttcaaatga
      181 acaacctgaa attggaggac acggccgtct attactgtgc gagagattca tatggcagcg
      241 gctccgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01005981             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21224:12247
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005981
VERSION     KCXD01005981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21224:12247"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64463.1"
                     /translation="CTTSSWGDDFW"
     D_segment       448..454
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          125 c          146 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcatct tcgatgacta
      241 tgccatgaac tgggtccgcc aggcttctgg gaaaggactg gagtggattg cctatattag
      301 aaacaagtat aacaattacg cgacagaata cgccgcgtcg gtgaagggca gattcaccat
      361 ctccagagat gattcaaaga acacggtatt tctgcaattg aacagcctaa aaaccgagga
      421 ctcggccgtc tattactgca ccacctccag ctggggcgac gacttctggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005982             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22803:6519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005982
VERSION     KCXD01005982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22803:6519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..450
     V_segment       87..380
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64464.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       384..391
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           89 a          134 c          126 g          103 t
ORIGIN      
        1 acatggggat ggacctcctg tgcaagaaca tgaagcacct gtggttcttc cttctcctgg
       61 tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc ccaggactgg
      121 cgaagccttc ggagaccctg tccctcacct gcgctgtctc tggtgactcc gtcaccagta
      181 gctactggaa ctggatccgc cagcccccag ggaagggact ggagtggatt gggtatatct
      241 ctggtgctta tgggagcacc agctacaacc cctccctcag gagtcgagtc accatttcaa
      301 cagacacgtc caagaaccag ttttccctga ggctgagttc tgtgaccgcc gcggacaccg
      361 ccgtgtatta ttgtgtgaga tatgaggatg aatccattaa ctaccacttt gacttctggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005983             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5229:12279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005983
VERSION     KCXD01005983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5229:12279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64465.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       444..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          111 a          114 c          149 g          122 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgcgat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcaacc
      181 ggaggggtcc ctgagactct cctgtgcagc ctctggattc accttcagtt tctatggctt
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tttcgaatga
      301 tgaaaataac aaatactacg cagactctgt gaaggaccga ttcaccattt ctagagacaa
      361 ttccatgaac atgctatttc ttcaaatgaa caacctgaac ttggacgaca cggccgtcta
      421 ttactgtgtg agagatgatt taggcagcgg cttagggtcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01005984             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:26803:11946
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005984
VERSION     KCXD01005984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:26803:11946"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64466.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           92 a          135 c          137 g          111 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggaccc cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctctcagc ggtggttatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggc tatatctatg gtggtagtgg gagcaccacc tacaacccgt ccctcaggaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttg tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagacag tgctgttact atgatgactt
      421 tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005985             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19463:4006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005985
VERSION     KCXD01005985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19463:4006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..360
     V_segment       1..282
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <276..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64467.1"
                     /translation="CANVMGPWGSWSHYFDYW"
     D_segment       301..310
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..360
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           75 a          107 c          102 g           78 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcggacag cctgtccctc acctgcgctg
       61 tctctggtgc ctccattaat agttactggt ggagctggat ccgccagccc ccagggaagg
      121 gactggagtg gattggggag atcaatggta ataatggtaa cacctactac aacccctccc
      181 tcaagagtcg actcaccatt tcaaaagacg cgtccaagaa tcagttctcc ctgaagctga
      241 gttctgtgac cgccgcggac acggccgtgt attactgcgc gaacgtcatg ggcccctggg
      301 gcagctggtc acattacttt gactactggg gccagggagt cctggtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01005986             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12540:5094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005986
VERSION     KCXD01005986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12540:5094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64468.1"
                     /translation="CARGPVTIFGVLITGLDYW"
     D_segment       426..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          142 c          143 g          103 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatccacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaaggacttg agtggatggg aggtgttgct cctctatatg gtgaaatgat
      301 gcacgcagac aacttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga cgacacggcc gtgtattact gtgcgcgtgg
      421 gcctgttaca atttttggcg tacttattac ggggcttgac tactggggtc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005987             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:10301:17397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005987
VERSION     KCXD01005987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:10301:17397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..498
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64469.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       433..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          138 c          148 g           99 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggcttctgga tacaccttca gcatctatgt catcaattgg gtgcgccagg
      241 cccctggaca agggctagag tggatgggag gaatcatccc tcttgttggt acaacaaact
      301 acgcacagaa gttccagggc agagtcacga ttattacgga cacgtccaca agcacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattactgt gcgagaggcc
      421 cccctactga agggggtgat tattctgggg gggctttgag ccgatggggc cagggagtcc
      481 aggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005988             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16856:9138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005988
VERSION     KCXD01005988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16856:9138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64470.1"
                     /translation="CTKGRSGGVWPNSFDYW"
     D_segment       426..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          134 c          141 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 cccaggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggtg aaataattgt
      301 cgcagacaat ttccaggaca gagtcaccat gaccgaggac acgtctaccg acacagccta
      361 catggagctg agcagcctgg aatctgacga cacggccatg tattactgta cgaaagggag
      421 gagtggtggt gtctggccga actcctttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01005989             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12153:11458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005989
VERSION     KCXD01005989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12153:11458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64471.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          139 c          148 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggactga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagatagc ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gtcaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01005990             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6720:20243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005990
VERSION     KCXD01005990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6720:20243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..477
     V_segment       87..380
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <372..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64472.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       399..421
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           96 a          137 c          135 g          111 t
ORIGIN      
        1 acatggggac ggacatcctg tgcaagaaca tgaagcacct gtggttcttc ctcctgctgg
       61 tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc ccaggactgg
      121 tgaagccttc ggagaccctg tccctcacct gtgatgtctc tggtgcctcc atcagtactt
      181 cctggtggac ctggatccgc cagcccccag ggaagggact ggagtggatt ggggagatca
      241 atggttatag tggtagtttt tactccaacc cctccctcaa cagtcgagtc accatttcaa
      301 aagacgcgtc caagaaccag ttcgccctga aactgagctc tgtgaccgcc gcggacacgg
      361 ccgtatatta ctgtgcgcga gatgccgggt ttggggaaac gatattagta gtcgatatta
      421 atatgttccc ccactttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005991             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8227:3345
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005991
VERSION     KCXD01005991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8227:3345"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..480
     V_segment       117..407
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64473.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       408..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          138 c          130 g           99 t
ORIGIN      
        1 acatggggac aacaaccaca tccctcccct acagaagccc cagagcacag ctcctcacca
       61 tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc cactctgagg
      121 tccaactggt gcagtctggg gctgaagtaa aggggcctgg ggcctcagtg aaggtctcct
      181 gcaaggtttc cggatacacc ttcaccgaat tatccataca ctgggtgcga caggcccctg
      241 gaaaaggcct tgagtggatg ggaggttttg gtcctgtgta tggtgaaata atacacacag
      301 agaagttcca gggcagagtc actatgaccg aggacacgtc tacagacaca gcctacatgg
      361 agctgagcag cctgagatct gaggacacgg ccgtctatta ctgtgcggca gctgatagtg
      421 gttacccatt ttactacttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01005992             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14890:17559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005992
VERSION     KCXD01005992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14890:17559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64474.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       399..403
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           96 a          145 c          135 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc acttcctact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggatat atctatgctg atagtgggac caccagctac aacccgtccc tcaagagtcg
      301 agtcaccatt tcaatagaca cgtccaagaa tctgtactcc ctgaaactga gctctgtgac
      361 cgccgcggac acggcctttt attactgtgc gagacgtcct actcgcacgc gggttctata
      421 tgaggcgaca ggggaagact ttgactcctg gggccaggga ctcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01005993             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9470:11953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005993
VERSION     KCXD01005993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9470:11953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..470
     V_segment       113..403
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64475.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       412..421
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           85 a          140 c          143 g          104 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcacggac ctcctgtgca agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca
      121 gctgcaggag tcgggcccag gactggtgaa gccttcggag accctggccc tcacctgcgc
      181 tgtctctggt ggctccatca gtggttactg gtggggctgg atccgccagt ccccagggag
      241 ggggctggaa tggattggat ttttcggtgg tagtggtggg aacacctact acaagtcctc
      301 cctccagagt cgagtcacca tttcagccga cccgtccaag aaccagttct ccctgatact
      361 gacctctgtg accgccgcgg acacggccct ctattactgt gcgcggggga atatagcagc
      421 gactggcatt gactactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01005994             325 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12980:22887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005994
VERSION     KCXD01005994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 325)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 325)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12980:22887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..323
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..323
     V_segment       5..253
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <245..>292
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64476.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       259..268
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..323
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        324..>325
                     /gene="IGHG"
BASE COUNT           74 a           83 c           93 g           75 t
ORIGIN      
        1 acatgggtct ctgagactct cctgtgtagc ctctggattc agcttcagaa gttacgaaat
       61 gagttgggtc cgccaggctc cgggaaaggg gctggagtgg gtctcatata ttagtcacac
      121 tggtgaaacc atataccacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      181 cgccaagaat tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      241 ttactgtact aggaaccgga atactgtaat gattgggtgg ttcgatgtct ggggcccggg
      301 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01005995             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5368:8052
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005995
VERSION     KCXD01005995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5368:8052"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64477.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       418..426
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          110 a          141 c          134 g           92 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag caactacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgag gtgatgcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg ggtgggaagt gttgatcctg catatggtga aatgacgttc
      301 cagggtagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagc
      361 agcctgacat ctgaggacac ggccgtgtat tactgcgcga ttggccctag tggcagatgg
      421 aacgactggt ccttcgacat ctggggacct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01005996             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5753:9449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005996
VERSION     KCXD01005996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5753:9449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64478.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       230..242
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           76 a           67 c           78 g           68 t
ORIGIN      
        1 acatggggga ttcaccttca gaaactatgg catgcactgg gtccgccagg ccccagggaa
       61 ggggctggat tgggtggcag ttatgtcgtt tgatgaaaat gtgaaattct acgcagactc
      121 tgtgaaggac cgattcacca tctccagaga caattccaag aacatgctat atcttcaaat
      181 gaacaacctg aaattggagg acacggcctt gtattactgt gcgagagggg aatacagtaa
      241 ctctattgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005997             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16254:6093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005997
VERSION     KCXD01005997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16254:6093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64479.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          116 c          146 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttt
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaaact ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatactt tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctactactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01005998             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17233:13932
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005998
VERSION     KCXD01005998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17233:13932"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64480.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          142 c          129 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctgctgaagc cttcggggac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcacc agtagcttct ggaactgggt ccgccagccc cccgggaagg ggctggagtg
      241 gattggctat atctctggtg ctactgggag taccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga attctgtgac
      361 cgccgcggac accgccgaat attactgtgc gagatatgac gcggatgatt acggttatta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01005999             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17582:4022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01005999
VERSION     KCXD01005999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17582:4022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64481.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          118 a          115 c          148 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggag gagagatttg gctacagttt tgacttttgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006000             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:25026:10007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006000
VERSION     KCXD01006000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:25026:10007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64482.1"
                     /translation="CAGGSRRQSENW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           83 a          131 c          140 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctatgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatcggtgg tactagtggg agtacctact acaatccctc cctcgagagt
      301 cgagtcacca tttcaacaga cacgtccaag aatctcttct ccctgaagat gagttcttta
      361 accgccgcgg acacggccat gtatttctgt gcgggcggaa gtcggcggca gtcggagaac
      421 tggggccagg gagtcctggt caccgtctct tcagcc
//
LOCUS       KCXD01006001             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10743:20749
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006001
VERSION     KCXD01006001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10743:20749"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64483.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       428..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          116 a          135 c          143 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag ttttccggaa aaaccttcac tgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatctt gcatatgatg aaataatgga
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cggcgggcct
      421 tgggggatat ttactgcata ctgaatactt cgagttctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01006002             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8379:3627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006002
VERSION     KCXD01006002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8379:3627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64484.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       440..445
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          111 c          150 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct atggcatcca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg acagttatat cgtatgatga
      301 aacaaagaaa tactacgcag actctctgaa ggaccgcttc atcatctcca gagacaattc
      361 caagaacatg gtatatcttc aaatgaataa cctgaaattg gatgacatgg ccgtatatta
      421 ctgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggtg tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006003             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17925:15250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006003
VERSION     KCXD01006003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17925:15250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64485.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       413..424
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          109 a           99 c          143 g          116 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcagc
      121 tggtggagtc tggaggaggc ttggttcagc cgggggggtc cctgagactc tcctgtgcag
      181 cctctggatt cagtttcagt aattatggca tgcactgggt ccgccaggct ccagggaagg
      241 ggctggaatg ggtggcagtt atgtcatctg atggaactaa gaaattctac gcagactctg
      301 tgaaggtccg attcaccatc tccagagaca attccaagaa catggtatat cttcaaatga
      361 acagcctgaa atcggaggac acggccgtat attattgtgg gagagatgat aatggggtga
      421 ttatcgacta ctggggccag ggagtcctgg tcaccgtcac ctcagcc
//
LOCUS       KCXD01006004             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19515:14897
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006004
VERSION     KCXD01006004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19515:14897"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64486.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          117 c          160 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcacagcctg
      181 gggggtccct gagactctcc tgttcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctccggtatt aatagtggtg
      301 gggaaactac atactacgca gactccgtga agggccgatt caccatctcc agagacaatt
      361 caaagaacac tctctccctg caaatgaaca gcctgagagc ggaggacacg gccgtgtatt
      421 attgtgtgca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006005             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17620:4839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006005
VERSION     KCXD01006005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17620:4839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64487.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       403..414
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           95 a          139 c          136 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaacta ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac gtatctctgg cagtggtggg agcaccgtct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagattt ccctgaaagt gacctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgacagccg gatatagcag cagcgaaagc
      421 ttctacggtt tggattcctg gggccaaggg gtcgtcgtca tcgtctcctc agcc
//
LOCUS       KCXD01006006             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14055:20378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006006
VERSION     KCXD01006006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14055:20378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64488.1"
                     /translation="CARVDTSTLDATAADYW"
     D_segment       435..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          118 c          151 g          124 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt catcttcagt acctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcactt atatcgtttg
      301 atggaagtaa gcaatattac gcagactctg tgaaggaccg attcaccatc tctagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 atttctgtgc gagagtggat acatctacac ttgatgcaac agcagctgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006007             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17210:9290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006007
VERSION     KCXD01006007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17210:9290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64489.1"
                     /translation="CARDGRGSGTDVW"
     D_segment       445..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          111 c          160 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccgtc agtagttttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatggaaa tacgagattc tacgcagact ctgtgaagga ccgattcacc atctccagcg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagagat gggcggggtt caggcacgga tgtctggggt cggggagttc
      481 tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01006008             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6663:17487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006008
VERSION     KCXD01006008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6663:17487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..444
     V_segment       84..377
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64490.1"
                     /translation="CVRVHDYAMYYFDSW"
     D_segment       383..390
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          100 a           99 c          133 g          114 t
ORIGIN      
        1 acatgggcag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctattttaa gaggttccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      121 agcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtagttatg
      181 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgc
      241 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctctagag
      301 acaattccaa gaatacggtt tttctgcaaa tgaattccct gaaaatggag gacacggccg
      361 tgtattactg tgtgagagtc catgactacg ctatgtacta ctttgactcc tggggccagg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006009             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13452:15846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006009
VERSION     KCXD01006009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13452:15846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64491.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       408..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           94 a          135 c          136 g          113 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 aggctctctc agcggtggtt atgactggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt ggctatatct atggtggtac tgggagcacc acctacaacc cgtccctcag
      301 gaatcgagtc accatttcaa aagacacgtc caagaaccag ttgtccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtatatta ttgtgcgaga cagtgctgtt actatgatga
      421 ctttttagac tactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006010             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:16122:10216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006010
VERSION     KCXD01006010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:16122:10216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64492.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       412..422
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          111 a          141 c          132 g           91 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgagggtctc
      181 ctgcaagatt tccggataca ccttcaccga attatccata cactgggtgc ggcaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcta tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagtag
      361 cctgacatct gaggacacgg ccgtgtatta ctgtgcgact ggccctagcg gcacctggaa
      421 cgcctggtac ctcgatatct ggggccctgg cacctcaatc accatctcct cagcc
//
LOCUS       KCXD01006011             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16693:5708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006011
VERSION     KCXD01006011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16693:5708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..484
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64493.1"
                     /translation="CAREYCTSDACAGFFDYW"
     D_segment       409..420
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          112 a          133 c          139 g          102 t
ORIGIN      
        1 acatggggga accacatccc tcctctaaag aagcccctgg gagcacagct catcaccatg
       61 gactggacct ggaggctcct ctttgtggtg gcagcagcta caggtgtcca gtcccaggtc
      121 cacttggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa ggtttcctgc
      181 aaggcttctg gattcaccct cgacaactat ggaatcaact gggtgcgaca ggcccctgga
      241 caagggctgg agtggatggg agtgatcatc ccccttgtcg gtatagtgaa ctacgtagag
      301 aacctccagg gcagagccac gataaccgcg gacacgtcaa caaacacagt ctacatggaa
      361 ttgaacagcc tgagatctga cgacacggcc atctattatt gtgcgagaga atactgtact
      421 tctgatgctt gcgccggatt ctttgactac tggggccagg gagtcccggt caccgtctct
      481 tcagcc
//
LOCUS       KCXD01006012             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18619:10351
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006012
VERSION     KCXD01006012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18619:10351"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64494.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       421..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          138 c          140 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg gatgcgacag
      241 gcccctggaa aagggcttga gtgggtgggg ggtgttgatc ctgaatatgg tgaaatgaca
      301 cacgtagaga aattccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtatttctg tgcagccgga
      421 tatagtggca gctggaactc ctggtacttc gatttctggg gtcctggcac cgcaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006013             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22917:11349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006013
VERSION     KCXD01006013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22917:11349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..397
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64495.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       398..404
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT          106 a          103 c          136 g          116 t
ORIGIN      
        1 acatggggtt ccattcggtg atcagcacag aacacagagg actcaccatg aagtttgggc
       61 tgagctgggt tttccttatt gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg
      121 agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt acagcctctg
      181 gattcacctt cagtagctat ggcttacact gggtccgcca ggctccaggg aaggggctgg
      241 agtgggtgac agttatatcg tctgatgaaa gtaggaaata ctacgcagac tctctgaagg
      301 accgattcac catttccaga gacaattcca agaacacgct atatcttcaa atgaacaacc
      361 tgaaattgga ggacacggcc gtgtattatt gtgcgaggga tgataatggg gtgcttatcg
      421 acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006014             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10074:7130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006014
VERSION     KCXD01006014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10074:7130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64496.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          139 c          134 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tggggagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01006015             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22210:17996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006015
VERSION     KCXD01006015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22210:17996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64497.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           83 a          133 c          145 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccacatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggaacagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacgtactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga gcagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006016             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14886:6750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006016
VERSION     KCXD01006016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14886:6750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64498.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       445..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          119 c          150 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgaa ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggttcggc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agttttggca
      241 tccactgggt ccgccaggct ccagggaagg gcctggagtg ggtggcagtt atatcgtctg
      301 atgaaagtaa gaaattctac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catactatat cttcaaatga acaacctgat gctggaggac acggccgtct
      421 attactgtgc gagagacgca tatggcagcg gctgtgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006017             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20502:4819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006017
VERSION     KCXD01006017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20502:4819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64499.1"
                     /translation="CATGPSGTWNAWFLDIW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          144 c          133 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaaa cctggggcct cagtgagggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttatcc atccactggg tgcggcaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctgcagac acagcctaca tggaactgag
      361 tagcctgaca tctgaggaca cggccgtgta ttactgtgcg actggcccta gcggcacctg
      421 gaacgcctgg ttcctcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006018             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20636:8564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006018
VERSION     KCXD01006018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20636:8564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64500.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          123 a          141 c          134 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006019             354 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:20159:12801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006019
VERSION     KCXD01006019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 354)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 354)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:20159:12801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..352
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..352
     V_segment       7..277
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <271..>321
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64501.1"
                     /translation="CVTSSSGTWLYWYFDVW"
     D_segment       291..297
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       301..352
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        353..>354
                     /gene="IGHG"
BASE COUNT           85 a           91 c          101 g           77 t
ORIGIN      
        1 acatgggggg ctgaggtgaa gaagcctggg gcctcagtga aggtctcctg caagatttcc
       61 ggatacacct tcaccgaatt atccatgcac tgggtgcgac aggcccctgg aaaagggctt
      121 gagtggatgg gaagtgttga tcctgtatat ggtgaaatta taaattcaga gaggttccag
      181 ggcagagtca ccctgaccga ggacacgtct acagacacag cctacatgga gctgagcagc
      241 ctgagatctg aagacacggc cgtgtattat tgtgtgacct catccagcgg cacctggcta
      301 tactggtact tcgatgtctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01006020             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:23276:9205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006020
VERSION     KCXD01006020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:23276:9205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64502.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          113 c          158 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaaa taagaaatac tacgaagact ctctgaaggc ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tggacaacct gaaattggaa gacacggccg
      421 tgtattactg cgcgagagat gtctggggga ggggatttga ctattggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006021             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15418:19283
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006021
VERSION     KCXD01006021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15418:19283"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64503.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       444..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          113 c          158 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg cggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gtagcctctg gattcacctt cagtagtagt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctggc tgttgaatcg
      301 catgatggaa ataagaaata ctatgcagac tccgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt atatcttcaa atgaacaacc tgaaattggt ggatacggcc
      421 atgtattact gtgtgagaga tgcctacggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006022             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21228:12598
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006022
VERSION     KCXD01006022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21228:12598"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..456
     V_segment       96..389
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64504.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       395..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           84 a          136 c          128 g          110 t
ORIGIN      
        1 acatggggct gagagtcatg gacctcctgt gcaagaacat gaagcacctg tggttcttcc
       61 ttctcctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc
      121 caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct ggtggctcca
      181 tcagcgatta cttctggaac tggatccgcc agtccccagg gagggggctg gagtggattg
      241 gatatctcta tggtgctact gggatcaccg gctacaaccc ctccctcaag agtcgagtca
      301 ccttttcagc agacacgtcc aagaaccagt tttccctgaa gctgacctct gtgaccgccg
      361 cggacaccgc cgtttattat tgtgcgagat atcagggtga ttccttgtac tactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006023             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9694:11703
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006023
VERSION     KCXD01006023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9694:11703"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64505.1"
                     /translation="CARTGDSGTYYSGEYFDYW"
     D_segment       444..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>517
                     /gene="IGHG"
BASE COUNT          121 a          114 c          155 g          127 t
ORIGIN      
        1 acatgggagc tctaggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca ggagttatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatctcgta
      301 tgatggaagt aagaaatatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattctaag aacatactac atcttcaaat gaacaacctg agattggagg acacggccgt
      421 gtattactgt gcgagaacag gggatagtgg tacttattat tcgggggaat actttgacta
      481 ctggggccag ggagtcctgg tcaccgtctc cttatcc
//
LOCUS       KCXD01006024             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15670:6588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006024
VERSION     KCXD01006024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15670:6588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64506.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT          117 a          142 c          131 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg ctacagcttc gccgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggttttgcta gtatatatgg tcaaataata
      301 catacagaga gattccaggg cagagtcacc atgacagcgg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctccgcc
//
LOCUS       KCXD01006025             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13327:6514
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006025
VERSION     KCXD01006025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13327:6514"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64507.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       405..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           90 a          138 c          133 g          110 t
ORIGIN      
        1 acatggggag gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca ccagtagctt ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tggtactggg agtaccagct acaatccctc cctcaggagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gaactctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg acgcggatga ttacggttat
      421 tattaccttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006026             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17811:11910
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006026
VERSION     KCXD01006026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17811:11910"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64508.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       404..411
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          143 c          135 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc gcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactcct ggagctggat ccgccagccc ccaggcaatg gtctggagtg
      241 gattggacat gtcagtggta gtagtgggag caccgactac aacccctccc tcaagagtcg
      301 attcaccatt tcaacagaca cgtccaagcg ccagttctcc ctgaggctga tttctgtgac
      361 cgccgcggac acggccgtct atcattgtgc gagagtccgg ggcgtgacta tctattactt
      421 tgactactgg ggccagggag ccctggtcac cgtcgcctca gcc
//
LOCUS       KCXD01006027             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14395:19991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006027
VERSION     KCXD01006027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14395:19991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64509.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       404..408
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           97 a          109 c          141 g          118 t
ORIGIN      
        1 acatggggag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgtttctatt ttaagaggtg tccagtgtga ggtgcagctg
      121 gtggagtctg gaggaggctt ggttcagcct ggggagtccc tgagactctc ctgtgcagcc
      181 tctggattct ccttcagtcg ctctggcatg cactgggtcc gccaggctcc agggaagggg
      241 ctggactggg tgtctgtaat gtcgtctgat ggaagtaaga aatactacgc agactctgtg
      301 aaggaccgat tcaccatctc cagagacaac tccaagaaca tactctatct tcaaatgaac
      361 aacctgaaat tggaggacac ggccgtgtat ttctgtgtga gagatgcctt cgggggcggt
      421 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006028             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20259:14622
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006028
VERSION     KCXD01006028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20259:14622"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64510.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          123 c          156 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 tgatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagagct gacgacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006029             364 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20913:4784
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006029
VERSION     KCXD01006029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 364)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 364)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20913:4784"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..362
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..362
     V_segment       8..301
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>331
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64511.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       310..316
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       323..362
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        363..>364
                     /gene="IGHG"
BASE COUNT           86 a           82 c          113 g           83 t
ORIGIN      
        1 acatggggag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg gggggtccct
       61 gagactctcc tgtgaagcct ctggattcac cttcaggagt tatggcatgc actgggtccg
      121 ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg tgagtaagaa
      181 atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt ccaagaacac
      241 gctatatctt caaatgaaca acctgaaatt ggaggacacg gccatttatt actgtgggag
      301 agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca ccgtctcctc
      361 agcc
//
LOCUS       KCXD01006030             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:10509:10646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006030
VERSION     KCXD01006030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:10509:10646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64512.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       401..408
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           84 a          137 c          132 g          111 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcag gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cgattacttc tggaactgga tccgccagtc cccagggagg gggctggagt
      241 ggattggata tatctatggt gctactggga gcaccggcta caacccctcc ctcaagagtc
      301 gagtcacctt ttcagcagac acgtccaaga accagttttc cctgaagctg acctctgtga
      361 ccgccgcgga caccgccgtt tattattgtg cgagatatca gggtgattcc ttgtactact
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006031             349 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15319:11565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006031
VERSION     KCXD01006031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 349)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 349)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15319:11565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..347
     V_segment       8..277
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <269..>316
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64513.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       280..295
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       299..347
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>349
                     /gene="IGHG"
BASE COUNT           73 a           92 c          107 g           77 t
ORIGIN      
        1 acatgggggg ggcggcttgg caaagcctgg gggatccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtacct atgctatgca ctgggtccgc caggctccag ggaaggggct
      121 ggagtgggtc tcagccatta gtgttggtgg tagtacatat tacgcagact ccgtgagggg
      181 ccgattcacc atctccagag acaactcaga gaacacgctc tccctgcaaa tgaacagcct
      241 gagagctgag gacacggccg tgtattactg tgcgaaaggg gatacagcta cagtttatta
      301 cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006032             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20110:2844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006032
VERSION     KCXD01006032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20110:2844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64514.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       440..444
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          118 c          150 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gctgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagaa atactacgca gactctttga aagaccgatt caccatatcc agagacaact
      361 ccaagaacat agtatatctt caactgaaca gcctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtgtat ggctcggggc ttgactactg gggccaggga gtcctgctca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006033             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21856:18299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006033
VERSION     KCXD01006033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21856:18299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64515.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          136 c          129 g          109 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggacaggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgtcag cccccaggga agggactgga
      241 gtggattggg tatatctctg gttcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006034             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8344:15272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006034
VERSION     KCXD01006034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8344:15272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..479
     V_segment       110..406
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64516.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       417..431
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          103 a          111 c          143 g          124 t
ORIGIN      
        1 acatggggag gtgttttcat ttgtgatcag cactgaacac agaagactca tcatggagtt
       61 tggcctgagc tgggttttcc ttgttgctat tttaaaaggt gtccagggtg aggtgcagct
      121 ggtggagtct gggggcggct tggcaaagcc tggggggtcc ctgagactct cctgtgcagc
      181 ctctggattc accttcagtg actactggat gtactgggtt cgccagacac ctgaacaggg
      241 gctggagtgg atctcagcta ttgatagtgc tggtactagt accacatact atgcagactc
      301 cgtgaagggc agattcacca tctccagaga gaacgccaaa aacacactgt atcttcagat
      361 ggacagtctg agaactgagg acacggctgt ctattactgt gcgagagttc cgggcctagt
      421 ggtatttact ggttcgcttg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01006035             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19288:3883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006035
VERSION     KCXD01006035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19288:3883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..339
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64517.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       283..296
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..339
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           78 a           81 c           99 g           83 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct
       61 tcagtagtta tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
      121 cagttatatc gtttgatgga agtaagaaat actacgcaga ctctatgaag gaccgattca
      181 ccatctccag agacaattcc aagaacatgc tagatcttca aatgagcaac ctgaaattgg
      241 aggacacggc cgtctattac tgtgcgagaa tggattgtac tggtggtgtc tgctactttg
      301 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006036             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22927:4074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006036
VERSION     KCXD01006036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22927:4074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64518.1"
                     /translation="CARGYCSGSFCSSAFDYW"
     D_segment       424..434
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          118 a          128 c          144 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt caggggctga gatgaagaag cctggggcct cagtgaaggt
      181 ctcttgcaag gtttccggaa acaccttcag cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggagg tgttgaacct ggatatggtg aaataatata
      301 tgcagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctga gatctgagga tacggccgtt tattactgtg cgaggggata
      421 ctgtagtggt agtttctgtt cgtcagcctt tgattactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006037             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17603:5149
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006037
VERSION     KCXD01006037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17603:5149"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..452
     V_segment       98..394
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64519.1"
                     /translation="CARWESADFDYW"
     D_segment       395..400
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       408..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           93 a          127 c          133 g          101 t
ORIGIN      
        1 acatggggct ctgagagtca cggacatcct gtgtaagaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgcacctgc aggagtcggg
      121 cccagcagtg gtgaagcctt cggagaccct gtccctcacc tgcgttgtct ctggtgcctc
      181 catcagcggt ggttatggct ggagctggat ccgtcaggcc ccagagaaag gactggagtg
      241 gattgggaat atctatggat atagtggtag cacaaactac aacccctccc tcaggagtcg
      301 agtcaccatt tcaaaagaca cgtccaagaa ccagttctcc ctgaagatga gctctgtgac
      361 cgccgcggac tcggccgtgt attattgtgc gagatgggag tcagcggact ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006038             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:15485:17419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006038
VERSION     KCXD01006038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:15485:17419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64520.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       413..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          146 c          137 g           88 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccctca ccgaagtgtc cactcactgg gtgcgacagg
      241 cccccggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtccacaga cacagcctac atggaactga
      361 gcagcccaag atctgaggac acggccgtgt attactgtgc gattggccct accggcaggt
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01006039             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15103:12721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006039
VERSION     KCXD01006039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15103:12721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..495
     V_segment       135..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64521.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       429..433
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..495
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          122 c          157 g          114 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actctcctgc gcagcctctg gattcaactt caattactac tacatgaact
      241 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattgac agtggtgggg
      301 atagcacata ctatgcggac tccgtgaagg gcagattcac catctccaga gagaacgcca
      361 agaacacact gtatcttcaa ttggacagcc tgagagctga ggacacggct gtctattact
      421 gtgcgagagt ggtgggtggt gccgcaggat acttcgactt ctggggccag ggcgccctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006040             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20883:20522
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006040
VERSION     KCXD01006040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20883:20522"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..280
     V_segment       8..193
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64522.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       207..220
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..280
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>282
                     /gene="IGHG"
BASE COUNT           65 a           74 c           89 g           54 t
ORIGIN      
        1 acatgggggg tgcgacaggc ccctgggaaa gggcttgagt ggatgggagt tgttgatcct
       61 gccaatggtg aagaaataca cgcagagaag ttccagggca gagtcaccat gaccgaggac
      121 acgtcgacag acacagccta catggacttg accagtctca gatctgagga cacggccatc
      181 tattactgtg cgacagggag gatcggtagc agcgcctggt ccaacctctt caccggtttg
      241 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006041             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20435:9297
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006041
VERSION     KCXD01006041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20435:9297"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..492
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64523.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       429..436
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>496
                     /gene="IGHG"
BASE COUNT          111 a          141 c          145 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgcagtgaag aggcctgggg cctcagttaa
      181 ggtctcctgc aaggtttccg gatactcctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtgtatg gtgaagaaat
      301 acacgcagag aatttccagg acagagtcac catgaccgag gacacgtcca cagacacagc
      361 ctacatggag ctgagcagcc tgagacgtga ggacacggcc gtgtatttct gtgcggcggg
      421 ccttgggggg tatttagttc ttactgaata cctcgaattc tggggccagg gcgccctggt
      481 caccgtctcc tccgcc
//
LOCUS       KCXD01006042             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10556:16116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006042
VERSION     KCXD01006042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10556:16116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..462
     V_segment       99..391
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <384..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64524.1"
                     /translation="CASADNGYPPYYFDNW"
     D_segment       401..407
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           89 a          139 c          128 g          108 t
ORIGIN      
        1 atgggggttc tctgagagtc acggacatcc tgtgcaagaa catgaagcac ctgtggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca gctgcagctg caggagtcgg
      121 gcccaggact ggtgaagcct tcggagaccc tgtctgtcac ctgcgctgtc tctggtgact
      181 ctctcagcag taactactgg agctggatcc gccaggcccc aggaaagggt ctggagtgga
      241 ttggatatat cttcggtggt gatagtaacg cctactacaa cccctccctc aagagtcgag
      301 tcaccctgtc agtagacacg tccaagagcc agttctccct gaggctgaac tctttgaccg
      361 ccgcggacac ggccgtctat tattgtgcga gcgctgataa tggttatccc ccctactact
      421 ttgacaactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006043             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6995:10662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006043
VERSION     KCXD01006043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6995:10662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..474
     V_segment       123..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64525.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       421..426
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          111 a          136 c          137 g           92 t
ORIGIN      
        1 acatggggac acataacaac cacgtccctc ctctaaagaa gcccctggga acacagctca
       61 tcaccatgga cttgacctgg aggctcctct ttgtggtggc agcagctaca ggtgcccagt
      121 cccaggtcca gctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagc
      181 tctcctgcaa ggcttctgga tacagcttca acatcgatgc catcagttgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag ggatcatccc tcttgtcggt ataacaaact
      301 acgcacagaa gttccagggc agagtctcga ttaccgcgga cacgtccaca agcacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt gtattactgt gcgatccaag
      421 ggaacagcca gtttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006044             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21642:21018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006044
VERSION     KCXD01006044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21642:21018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64526.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          123 a          137 c          134 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatact caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006045             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11648:9421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006045
VERSION     KCXD01006045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11648:9421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64527.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           94 a          139 c          129 g          100 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg aaaggggctg
      241 gagtggattg ggtgtatcgg aggtaatagt ggtaccacct actacaaccc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc aacaatcaac tctccctgaa gctgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006046             387 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:23917:12376
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006046
VERSION     KCXD01006046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 387)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 387)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:23917:12376"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..385
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..385
     V_segment       69..318
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <310..>354
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64528.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       328..337
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       338..385
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        386..>387
                     /gene="IGHG"
BASE COUNT           81 a          116 c          101 g           89 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg agtctctgaa gatctcctgt aagacttctg gatacagttt taccagctac
      121 tggatcacct gggtgcgcca gatgcccggg aaaggcctgg agtggatggg ggcgattgat
      181 cctagtgatt ctgctaccaa atacagcccg tccttccaag gccaggtcac catttcagcc
      241 gacaagtcca tcaccaccgc ctacctggag tggagcagcc tgaaggcctc ggacaccgcc
      301 acgtattact gtgcgaaagg tcccggagtg attattaact actttgacta ctggggccag
      361 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006047             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19545:5794
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006047
VERSION     KCXD01006047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19545:5794"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64529.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          134 c          136 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca ggtgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattggat acatctatgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagtgct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006048             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14468:9510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006048
VERSION     KCXD01006048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14468:9510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64530.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          111 c          158 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg atttactttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatac tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacagcct gaaattggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006049             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20211:14383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006049
VERSION     KCXD01006049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20211:14383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64531.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       410..416
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          100 a          135 c          127 g          104 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtcc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcggttact actggaactg gatccgccaa ccaccaggga aggggctgga
      241 gtggattggc tatatcgctg gtagtagtgg gagcatcgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaatcaattc tccctgaagc tgaactctgt
      361 gaccgccgcg gacacggcca tctattactg tgcgagaaat agatttatgg gtataagagt
      421 tcttgcctac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006050             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:27416:10856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006050
VERSION     KCXD01006050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:27416:10856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..513
     V_segment       141..434
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64532.1"
                     /translation="CTRIGVGSLATTGQYFDYW"
     D_segment       458..464
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          111 a          123 c          154 g          127 t
ORIGIN      
        1 acatggggga gctctgagac aggagcctta gccctggatt ccaagaactt ccactttggg
       61 atcagctctg aacacagagg accatggagt tggggctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggaggc ttggtccagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cacctttggt gattatggca
      241 tgcactggat ccgccaggct ccgggaaagg gactggagtg ggtctcatcc attagaaaca
      301 ctggtaaaac tatatattat gctgactccg tgaagggccg attcaccatt tccagagaca
      361 acgccaagaa ctcgttgtct ctgcaaatgg acagcctgag agccgaggac acggccgtgt
      421 attattgtac tagaattggc gtcggatctc tagcaacgac tggtcagtac tttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006051             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:14956:5333
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006051
VERSION     KCXD01006051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:14956:5333"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64533.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       419..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          112 a          149 c          135 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcgc cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgaat ggatgggcgg cgttgatcct gcatatggtg aattttcacc
      301 cggagagaag ttccagggca gactcaccat gaccgaggac acgtctgtag acacagccta
      361 catgaacctg agcagcctga actctgagga cacggccgtc tattactgtg cagccggata
      421 tagcggcagc tggaaccact ggtacttcga tctctggggc cctggcaccc ccatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006052             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:24486:13620
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006052
VERSION     KCXD01006052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:24486:13620"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64534.1"
                     /translation="CTRYGGDRGDWYFDYW"
     D_segment       414..420
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          138 c          138 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggagctgggt ccgccagccc ccagggaagg ggctggactg
      241 gattgggtat atctatggtg gtagtgggag caccggctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaaactga actctctgac
      361 cgccgcggac accgccgtgt attactgcac gagatatggg ggagatcggg gcgactggta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006053             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19168:4306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006053
VERSION     KCXD01006053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19168:4306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64535.1"
                     /translation="CAAGYSGSWNYWYFDFW"
     D_segment       436..444
                     /gene="IGHD1-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          138 c          143 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcagcgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtgggtg gggggtgttg atcctgtata tggtgaaatg
      301 atacacgtag agaagttcca gggcagagtc accctgaccg aggacacgtc tacagacaca
      361 gcctacatgg aactgagcag cctgagatct gaggacacgg ccgtgttttt ctgtgcagcc
      421 gggtacagtg gcagttggaa ctactggtac ttcgatttct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01006054             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12534:14974
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006054
VERSION     KCXD01006054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12534:14974"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64536.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          111 c          152 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgtaact aagaaatatt acgcagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaataacctg aaaatggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006055             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:19036:10136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006055
VERSION     KCXD01006055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:19036:10136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64537.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          125 c          159 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcactc aacacagaac ataccatgga gtatgtgctg agttgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatcccag gtattaacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006056             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5388:4140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006056
VERSION     KCXD01006056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5388:4140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64538.1"
                     /translation="CVRVVETATIYPSFDYW"
     D_segment       403..417
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           93 a          138 c          135 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccacca gcattaataa ctggtggagt tggatccgcc agtccccagg gaaggggctg
      241 gagtggattg ggggtgtcta tagtattggt ggggtcaccg aatacaaccc ctccctcaag
      301 agtcgagtca ccatctcaaa agacacgtcc aagagccagt tctccctgaa tctgagctct
      361 gtgaccgccg cggataccgc catatattac tgtgtgagag tcgtggagac agctacaatt
      421 tacccctcct ttgactactg gggccgggga gtcctggtca tcgtctcctc agcc
//
LOCUS       KCXD01006057             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17127:4252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006057
VERSION     KCXD01006057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17127:4252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64539.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          122 a          141 c          135 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg agatgggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga actgagcagt ctgagatctg aggacacggc cgtatattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01006058             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9883:11740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006058
VERSION     KCXD01006058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9883:11740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..457
     V_segment       100..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64540.1"
                     /translation="CAREGISAAGVDYW"
     D_segment       396..402
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           81 a          137 c          144 g           97 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcaact tcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagtccc cagggaaggg gctggagtgg
      241 attgggtttt tcggtggtcg caatgggaac acctactaca acccctccct caagagtcga
      301 gtcaccattt caccagacac gtccaagaac cagttctccc tgaggctgag gtctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agggagggga tatcagcggc gggggtcgac
      421 tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006059             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16613:12218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006059
VERSION     KCXD01006059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16613:12218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64541.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       283..287
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           72 a           84 c          106 g           81 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagttcct ttggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggactgggtg gcagttatgt cgtctgatgg aagtaacaag tactacgcag actctgtgaa
      181 ggaccgattc accatctcca gagacaattc caagaacatg gtttatcttc aaatgaacaa
      241 cctgaaattg gaggacacgg ccgtgtatta ctgtgcgaga gatgtctttg gcggggggct
      301 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006060             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10362:16037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006060
VERSION     KCXD01006060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10362:16037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64542.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          142 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcc aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatggta
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006061             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21555:18420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006061
VERSION     KCXD01006061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21555:18420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..448
     V_segment       94..390
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64543.1"
                     /translation="CARWSAANFDYW"
     D_segment       395..401
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           90 a          131 c          136 g           93 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgggc aagaacatga ggcatctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg gggctccatc
      181 agcagtggtt atggctggag ctggatccgc cagcccccag ggaaggggct ggagtggatg
      241 gggtgtatct atgatagtag tggaaacacc tactacaacc cctccctcaa gagtcgagtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga agctgaggtc tatgaccgcc
      361 gcggacacgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006062             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18514:13367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006062
VERSION     KCXD01006062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18514:13367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64544.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       447..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          114 a          124 c          147 g          129 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcagtg actatgccct
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg attggctata ttagaagcca
      301 atataacaat ttcgcgacag aatacgcccc atcggtgaaa ggcagattcg ccatctccag
      361 agatgattca aagaacacgc tatttctgca aatgagtagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgcaccaccc attttggtgg taattattac ttggactact ttgtctactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006063             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15964:13712
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006063
VERSION     KCXD01006063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15964:13712"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64545.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          138 c          138 g          101 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaggtaca ggcgcccact
      121 ctgaggtcca gctggtgcag tcgggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgtttttggt gaaataatga
      301 attcagagaa gttccagggc agagtcgcct tgaccgagga cacgtctaca gacacagcct
      361 acatggagtt gagcagcctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatat tggtacttcg atgtctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01006064             377 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16875:8631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006064
VERSION     KCXD01006064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 377)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 377)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16875:8631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..375
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..375
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>344
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64546.1"
                     /translation="CARELSPYDYFWSDFYSYYFDYL"
     D_segment       319..324
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       328..375
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        376..>377
                     /gene="IGHG"
BASE COUNT           75 a          114 c          100 g           88 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaaac cttcggagac cctgtccctc acctgcgctg
       61 tctctggtgg ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg
      121 gactggagtg gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc
      181 tcaaaagtcg agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga
      241 gctctgtgac cgccgcggac acggccgtgt attactgtgc gagagagctt tccccctacg
      301 actatttttg gagtgatttt tactcttact actttgacta cttgggccag ggactcctgg
      361 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006065             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21281:9250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006065
VERSION     KCXD01006065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21281:9250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..450
     V_segment       96..389
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64547.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       392..396
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           97 a          102 c          142 g          111 t
ORIGIN      
        1 acatgggggt gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg
       61 ttttccttgc tgttatttta agaggtgtcc agtgtgacgt gcagctggtg gagtctggag
      121 gaggcttggt tcagcctggg gggtccctga gactctcctg tgcaggttct ggattcacct
      181 tcagtaactt tggcatgcac tgggtccgcc aggctccagg gaaggggctg gactgggtgg
      241 ctgttatgtc gtctgatgga agtaagaaat actacgcaga ctctgtgaag gaccgattca
      301 ccatctccag agacaattcc aagaacatgg tatatcttca agtgaacacc ctgaaattgg
      361 aggacacggc cgtgtattac tgtgcgagag atgtctttgg cgggggactt gactactggg
      421 gccagggagt cccggtcacc gtctcctcag cc
//
LOCUS       KCXD01006066             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18832:16243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006066
VERSION     KCXD01006066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18832:16243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..456
     V_segment       105..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64548.1"
                     /translation="CAGGSRRQPENW"
     D_segment       407..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           83 a          132 c          142 g          101 t
ORIGIN      
        1 acatgggggg atgctctctg agagtcacgg acctcctatg caagagcatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcggttac tggtggggct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg gtatatcggt ggtactagtg ggagtaccta ctacaatccc tccctcgaga
      301 gtcgagtcac catttcaaca gacacgtcca agaatctctt ctccctgaag atgagttctt
      361 taaccgccgc ggacacggcc atgtatttct gtgcgggcgg aagtcggcgg cagccggaga
      421 actggggcca gggagtcctg gtcaccgtct cttcagcc
//
LOCUS       KCXD01006067             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22850:14387
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006067
VERSION     KCXD01006067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22850:14387"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64549.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       440..448
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          115 a          111 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaataggcta tatcttcaaa tgaacaacct gaaattggag gacacggcag
      421 tgtattactg tgcgagagat gatagtgggg tgatcatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01006068             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:25175:15117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006068
VERSION     KCXD01006068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:25175:15117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64550.1"
                     /translation="CARRGIAAGWSFDYW"
     D_segment       440..450
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          110 a          121 c          159 g          112 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtacagct ggtggagtct gggggcggct tggcaaagcc
      181 gggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcagtt cctactacat
      241 gaactgggtc cgccaggctc caggaaaggg gctggagtgg atctcaggtg ttaacagcgg
      301 tggggagagt acatactatg cagactccgt ggagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga cctgaggaca cggctgtcta
      421 ttactgtgcg agaagaggga tagcagctgg atggagcttt gactactggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006069             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:26976:15603
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006069
VERSION     KCXD01006069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:26976:15603"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64551.1"
                     /translation="CVRYGADYEDDYDYYSFDYW"
     D_segment       405..430
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           96 a          133 c          135 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acttgcgctg tctctggtga
      181 ctccatcacc agtagcttct ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctatggca gtactgggag caccggctac aatacctccc tcaagagtcg
      301 agtctccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga attctgtgac
      361 cgccgcagac accgccgtgt atttctgtgt gagatatggg gcggattacg aggatgatta
      421 cgattactat agttttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006070             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14358:12300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006070
VERSION     KCXD01006070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14358:12300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..506
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64552.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       444..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          122 c          156 g          124 t
ORIGIN      
        1 acatggggga gacaggagtc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgg agctggtgga gtctggggga ggcttggtcc agccgggggg
      181 gtccctgaga ctctcctgtg tagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccatcagaa acactggtaa
      301 aatcgtatac tacgctgact ccgtgaaggg ccgattcatc atctccagag acaacgccaa
      361 gaattcgctg tctctgcaaa tgagcagcct gagagtcgag gactcggccg tctattactg
      421 tactagaatt ggcgtcggat ctctagcacc ggctggtgaa tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006071             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10706:15996
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006071
VERSION     KCXD01006071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10706:15996"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..489
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64553.1"
                     /translation="CANGMSGLDYW"
     D_segment       434..438
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          102 a          123 c          154 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca ggtattacta
      301 gtggtggtaa cacatacttc gcagactccg tgaagggccg attcaccatc tccagagacg
      361 actcaaagaa cacagtctcc ttgcaaatga acagtctgag acctgaggac acggccgtgt
      421 attactgtgc gaatgggatg tcagggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006072             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:25795:18331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006072
VERSION     KCXD01006072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:25795:18331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64554.1"
                     /translation="CASGFSGRWILWYFEIW"
     D_segment       421..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          140 c          138 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggccctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggacaga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggcg aaatgataga
      301 cgcagagaag ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg aacagcctga gatctgagga cacggccgtg tattattgtg cgagcggctt
      421 tagcggcagg tggatcctct ggtatttcga aatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006073             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17804:17961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006073
VERSION     KCXD01006073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17804:17961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64555.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          141 c          137 g          107 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccgcctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg cggggcttct ggattcaccc tcgacaccta tggtatcaac tgggtgcgac
      241 aggcccctgt acaagggctt gagtggatgg gagtggtcat cccccttatt ggtatcataa
      301 actacgcaaa gaactctcag ggcagactca caataaccgc gaacacgtcc acaaatacag
      361 cctatttgga actgagcagt ctgagatctg aggacacggc catctattac tgtgcgagag
      421 aatactgtac ttctagttct tgcgccgggt tccttgacta ctggggccag ggagccctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006074             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20932:10568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006074
VERSION     KCXD01006074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20932:10568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64556.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          109 c          157 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtatc tttggcatgc
      241 attgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaagtaagaa atactacaca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaaaat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgcgcgag agacgatttt ggcagcggct tagggtactg gggccaggga gccctggtga
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006075             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:9391:8765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006075
VERSION     KCXD01006075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:9391:8765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..441
     V_segment       81..374
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <366..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64557.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       381..388
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           96 a          103 c          137 g          107 t
ORIGIN      
        1 acatgggaaa cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc
       61 ttttgaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggtaaagc
      121 ctggggggac cctgagactc tcctgcgcag cctctggatt cagcttcagt tatttctaca
      181 tgagctgggt ccgtcaggcc ccagggaagg ggctggagtg gatctcaagt attgacaatg
      241 gtgggactac cgcaatttat gcagactccg tgaggggcag attcagcatc tccagagaga
      301 acgccaagaa cacactgtat cttcaaatgg acagcctgag agctgaggac acggctgtct
      361 attattgtgc gagagcacgc ggggtgatca ttacatactt tgactcctgg ggccagggag
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006076             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:10714:16772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006076
VERSION     KCXD01006076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:10714:16772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..466
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64558.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       403..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           89 a          142 c          127 g          110 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctgctgac
      181 tccatcacca gtagcttctg gaactggatc cgccagcccc cagggagggg gctggagtgg
      241 attggctata tctctggtgc tactgggagt tccagctaca acccctccct caagagtcga
      301 gtctccattt caacagacac gtccaagaac cagttttccc tgaagctgaa ctctgtgacc
      361 gccgcggaca ccgccgtgta ttactgtgcg agatatgacg acgatgatta cggttcttat
      421 taccttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006077             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16884:13425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006077
VERSION     KCXD01006077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16884:13425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64559.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          145 c          141 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgatgaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccctcagc atctctgcca tcagttgggt acgacaggcc
      241 cctggacaag ggcttgagtg gatgggagag atcttccctc ttgttggtgt gacaaaatac
      301 gcacagaact tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctgc gcggcctgag atctgaggac acggccgtat attactgtgc gagaagaggt
      421 ggccacggta ccaccaccac gttgtacttc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006078             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13176:4458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006078
VERSION     KCXD01006078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13176:4458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..491
     V_segment       101..394
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64560.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       413..435
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT           98 a          141 c          139 g          115 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgtgatg tctctggtgc
      181 ctccatcagt acttcctggt ggacctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggggag atcaatggtt atagtggtag tttttactcc aacccctccc tcaacagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttcgcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtat attactgtgc gcgagatgcc gggtttgggg aaacgatatt
      421 agtagtcgat attaatatgt tcccccactt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006079             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23199:15863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006079
VERSION     KCXD01006079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23199:15863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64561.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       448..464
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          120 c          154 g          126 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccctc agtaactact
      241 ggatgtactg ggttcgccag gcaccaggga aggggctgga gtggatctca gctattaata
      301 gtgttggtga tagcacatac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agagcgccaa gaacacacta tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcgagagta ccgggcctag tggtatttac tgcttcactt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006080             453 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6758:17546
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006080
VERSION     KCXD01006080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 453)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 453)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6758:17546"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..451
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..451
     V_segment       100..390
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>420
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64562.1"
                     /translation="CAGGSRRQPENW"
     D_segment       402..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..451
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        452..>453
                     /gene="IGHG"
BASE COUNT           82 a          132 c          139 g          100 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacctc ctatgcaaga gcatgaagca cctgtggttc
       61 ttcctcctcc tggtggtagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagcg gttactggtg gggctggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggtata tcggtggtac tagtgggagt acctactaca atccctccct cgagagtcga
      301 gtcaccattt caacagacac gtccaagaat ctcttctccc tgaagatgag ttctttaacc
      361 gccgcggaca cggccatgta tttctgtgcg ggcggaagtc ggcggcagcc ggagaactgg
      421 ggccagggag tcctggtcac cgtctcttca gcc
//
LOCUS       KCXD01006081             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15923:7666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006081
VERSION     KCXD01006081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15923:7666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64563.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          113 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc ggaacctatg
      241 gcatgcactg ggtccgccag gctccaggga tgggcctgga gtgggtgacg gttatatcga
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacgt gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcgtttggta gcgggcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006082             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21104:8742
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006082
VERSION     KCXD01006082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21104:8742"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64564.1"
                     /translation="CATGNIGSSGWSSLFTGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          147 c          148 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg gaaagggctt gagtggatgg gagttgttga tcctgtcaac ggtgaagaaa
      301 tacacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga cttgaccagt ctcagatctg aggacacggc cgtctattac tgtgcgacag
      421 ggaacatcgg tagcagcggc tggtccagcc tcttcaccgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtttcc tcagcc
//
LOCUS       KCXD01006083             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:17474:6844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006083
VERSION     KCXD01006083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:17474:6844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64565.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       441..447
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          111 c          152 g          117 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcacctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgaagcc tctggattca ccttcagtag ttatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtatgat
      301 gtaagtaaga aatactacgc agacgctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca ccctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtggga gagatgataa tggggtgctt atcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006084             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16647:19433
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006084
VERSION     KCXD01006084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16647:19433"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64566.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          117 c          149 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttata
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca gttatatcgt
      301 acgatgaaac taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01006085             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21462:14463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006085
VERSION     KCXD01006085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21462:14463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64567.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       439..443
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          115 c          157 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttct attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgt
      121 tattttaaga ggtgtccagt gtgacgtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc aggttctgga ttcaccttca gtaactttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggac tgggtggctg ttatgtcgtc
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaagt gaacaccctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tctttggcgg gggacttgac tactggggcc agggagtccc
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006086             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18651:4042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006086
VERSION     KCXD01006086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18651:4042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64568.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          122 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctattttaag aggtgtccag tgtgaggtcc acctggtgga atctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agttcctttg
      241 gcatgcactg ggtccgccag gcaccgggga aggggctgga gtgggtggca gttttatcgt
      301 ctgatggaag taacaaatac tacgcagact ctttgaaaga ccgattcacc atatccagag
      361 acaactccaa gaacatacta tatcttcaac tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagat gtgtatggct cggggcttga ctactggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01006087             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:15378:16625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006087
VERSION     KCXD01006087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:15378:16625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64569.1"
                     /translation="CARDESALSYPFEYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           87 a          145 c          133 g           98 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ccccatcagc agtaactact ggacctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggacgc atctatggtg ttcgtgggac taccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaaggtga cctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gcgagacgag agcgccttgt cttacccctt
      421 tgagtactgg ggccagggag tctcggtcac cgtctcctca gcc
//
LOCUS       KCXD01006088             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8183:21523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006088
VERSION     KCXD01006088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8183:21523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64570.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       430..438
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          124 c          148 g          107 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcggcca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacagtgt caccgaatta tcgcttcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgtaaaag gtgaagaaat
      301 tcacggagag gagttccagg acagagtcac catgaccgag gacccgtcta cagacacagc
      361 ctacatggag ttgagcaacc tgagatctga ggacacggcc gtgtattatt gtgcgagtgg
      421 gtttagtatc tggttatttt atgacgtttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006089             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18386:19870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006089
VERSION     KCXD01006089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18386:19870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64571.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       429..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          146 c          147 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgta aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggga aagggcttga atggatggga gttgttgatc ctgtcaatgg tgaagaaata
      301 cacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggact tgaccagtct cagatctgag gacacggcca tctattactg tgcgacaggg
      421 aggatcggta gcagcggctg gtccagcctc ttcaccggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006090             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16495:12512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006090
VERSION     KCXD01006090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16495:12512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..462
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64572.1"
                     /translation="CARDAGTGTPFDYW"
     D_segment       407..413
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           92 a          144 c          131 g           97 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acctcctgtg caagaacatg aggcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctacagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtaac ttctggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg acgtatctat ggtagtactg atagcaccag ctacaacccc tccctcacga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga tgcgggaact gggaccccct
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006091             424 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12620:9554
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006091
VERSION     KCXD01006091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 424)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 424)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12620:9554"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    59..422
                     /note="immunoglobulin heavy chain variable region"
     V_region        59..422
     V_segment       59..351
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <344..>391
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64573.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       364..372
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       381..422
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        423..>424
                     /gene="IGHG"
BASE COUNT           79 a          125 c          125 g           95 t
ORIGIN      
        1 acatgggcac ctgtggttct tcctcctcct ggtggcagct cccagatggg tcctgtccca
       61 gctgcagctg caggagtcgg gcccaggact ggtgaagcct ccggagaccc tgtccctcac
      121 ctgcgctgtc tctggtggct ctatcagcag tagttactgc agctggatcc gccagacccc
      181 agggaaggga ctggagtgga ttgggtatat ctatgggagt tatagtagta ccaactacaa
      241 cccctccctc aagagtcgag tcaccctgtc agtggacacg tccgagaacc agtgctccct
      301 gaagctgagc tctgtgaccg ccgcggacac ggccgtgtat tattgtgcga gttcgggtat
      361 agaagtggtt gcctacagca ttgactactg gggccaggga gtcctggtca ccgtctcctc
      421 agcc
//
LOCUS       KCXD01006092             540 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12039:21896
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006092
VERSION     KCXD01006092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 540)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12039:21896"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    184..538
                     /note="immunoglobulin heavy chain variable region"
     V_region        184..538
     V_segment       184..475
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <469..>507
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64574.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       486..491
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       497..538
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        539..>540
                     /gene="IGHG"
BASE COUNT          118 a          136 c          164 g          122 t
ORIGIN      
        1 acatggggct ccctctgctg atgaaaacca gcccagccct gaccctgcag ctctgggaga
       61 ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga acacagagga
      121 ctcaccatga agtttggact gagctgggtt ttccttgttg ctattttaag aggtgtccag
      181 tgtgaggtgc agctggtgga gtctggagga ggcttggttc agcctggggg gtccctgaga
      241 ctctcctgtg cggcctctgg attcaccttc agtacctatg gcatgcactg ggtccgccag
      301 gctccaggga aggggctgga gtgggtggcg gttatatcga atgatgaaag taacaaatac
      361 tacgcagact ctgtgaaggg ccgattcagc atctccagag acaattcgaa gaacatgcta
      421 tatgtgcaca tgaacaccct gcaattggac gacacggccg tgtattactg tgcgacagat
      481 gcgtttggta gcgggattga ccactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006093             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20655:19095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006093
VERSION     KCXD01006093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20655:19095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..469
     V_segment       115..408
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64575.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       418..423
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          105 a          103 c          143 g          120 t
ORIGIN      
        1 acatgggagt ccacagtgtt ccattcggtg atcagcacag aacacagagg actcaccatg
       61 aagtttgggc tgacttgggt tttccttgtt gctattttaa gaggtgtcca gtgtgaggtg
      121 cagctggtgg agtctggggg aggcttggtt cagcctgggg ggtccctgag actctcctgt
      181 gcagcctctg gattcatgtt cagtaactat ggcatccact gggtccgcca ggctccaggg
      241 aaggggctgg agtgggtgtc agttatatcg tatgatgtaa ctgtgaaata ctacgcagac
      301 tctgtgaagg accgattcac catctccaga gacaattcca agaacacgct atatcttcaa
      361 atgaacaacc tgaaattgga ggacacggcc gtgtattatt gtgtgagaga tgtcagggga
      421 acggggtttg acttctgggg ccagggagtc ctggtcaccg tctcgtcagc c
//
LOCUS       KCXD01006094             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13458:2953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006094
VERSION     KCXD01006094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13458:2953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..500
     V_segment       131..424
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64576.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       439..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          118 a          142 c          144 g           98 t
ORIGIN      
        1 acatggggca gagtacatgg ggacccaaca acaacacccc tccacagaag cccctggatc
       61 acagctcctt gccatggact ggacctggag gatcctcttc ttggtggcag cagcaacagg
      121 tgcccactcc caggtgcagc tggtgcagtc gggggctgag gtgaagcagc cggggacatc
      181 agtgaaggtc tcctgcaagg cttctggcta caccttcact agctatggta tgaactgggt
      241 gcgacaggcc cagggacaac ggcttgagtg gatgggatgg ctcaacaccg acactgggaa
      301 cccaacgtat gcccagggct tcaaagaacg atttacattc tccatggaca cctctatgac
      361 cacggcatat ctgcagatca gcagcctaaa gactgaggac acggccgtat actactgtgc
      421 aagaagtttg ggctggcatg attataatga cgtcgccctt gacttctggg gccagggagt
      481 cctggtcgcc gtctcctcag cc
//
LOCUS       KCXD01006095             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12183:16707
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006095
VERSION     KCXD01006095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12183:16707"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64577.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          138 c          127 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcttggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccaggc ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatggaac caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccagttttcc ctgaggctgg gttctgtgac
      361 cgccgcggac accgccgtat attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006096             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6104:18579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006096
VERSION     KCXD01006096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6104:18579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..511
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64578.1"
                     /translation="CTRIGFGSLAVAGHYFDFW"
     D_segment       454..463
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          103 a          127 c          155 g          128 t
ORIGIN      
        1 acatgggagc tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcacctg gtggagtctg ggggagactt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca cctttggtga ttatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatccat tgataggacg
      301 gctaaaaccg tctactacgc tgactccgtg aggggccgat tcaccatttc cagagacaac
      361 gccaagaact cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tattgtacta gaattggctt tggatctcta gcagtggctg gtcactactt tgacttctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006097             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15086:4851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006097
VERSION     KCXD01006097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15086:4851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64579.1"
                     /translation="CSTWRYYYSVGYPTFDYW"
     D_segment       445..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          117 a          119 c          152 g          129 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc atcttcagtg actttgccat
      241 gagttgggtc cgccaggctt ctgggaaagg actggagtgg gttggctatg ttagaaccaa
      301 atataacaat tacgcgacag aatacgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacga tatatctgca aatgagcagc ctgaaaaccg aggacacggc
      421 cgtgtatttc tgcagcacat ggaggtatta ttatagtgtt ggttatccca cctttgacta
      481 ctggggccag ggagtcctgg tcgccgtctc ctcagcc
//
LOCUS       KCXD01006098             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16096:6500
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006098
VERSION     KCXD01006098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16096:6500"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64580.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          116 c          148 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca attggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttagttcgtc
      301 tgatggaagt aacaaatact acacaaactc tgtgaagagc cgattcaccg tctccagaga
      361 caattcccag aacatacttt atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006099             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18037:4475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006099
VERSION     KCXD01006099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18037:4475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64581.1"
                     /translation="CARGIDNYHYTDTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          116 c          150 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctatg
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggaatctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctttgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggactggg tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatgtccag agacaatgcc
      361 aagaactccg tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtgcaaggg ggatagataa ctaccactat actgatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006100             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17162:9637
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006100
VERSION     KCXD01006100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17162:9637"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64582.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          114 c          143 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cggtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcaacctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact ttggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg acagttattt cgtctgatgg
      301 aactaacaaa tactacgcaa actctgtgaa gagccgattc accatctcca gagacaattc
      361 caagaacata ctatatcttc aaatgaacaa cttgaaattg gaggacacgg ccgtctatta
      421 ctgtgcgaga gatgatattg ggaccggttt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006101             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:4466:10420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006101
VERSION     KCXD01006101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:4466:10420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64583.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       452..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          119 c          150 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggcg cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcggcctctg aattcccctt tagcagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatagtg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006102             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:23236:19465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006102
VERSION     KCXD01006102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:23236:19465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64584.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          121 a          139 c          139 g          102 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgtcagg cttctggata ttccctcact cactacttca tgcactgggt gagacaggcc
      241 cctggacagg gccttgagtg gataggactg atcacccctc aaaatgatca taaagtctac
      301 gcacagaact tccagggcag agtcaccata actacggaca cgtccacgag cacagtgtcc
      361 atggagctga gcagcctgag atccgaagac acagccgtat actactgtgc gagagggggg
      421 gacatagaat attgtactgg tagtggttgt ggggagcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006103             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:9114:8566
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006103
VERSION     KCXD01006103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:9114:8566"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64585.1"
                     /translation="CARGYCHGTYCSSGLVSW"
     D_segment       429..444
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          142 c          140 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga agtgaggagg cctggggcct cagtgaaggt
      181 ctcctgcaag ctttccggac acaccttcag cgaattatcc gtcaactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggagg tgttcatcct ctatatggta aaataacaca
      301 cgcagagaac ttccaggaca gagtcctcat gaccgaggac acgtcgacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtc tactattgtg cgagaggata
      421 ttgtcacggt acttattgct cctcgggtct tgtgtcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006104             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18806:18138
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006104
VERSION     KCXD01006104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18806:18138"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64586.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          113 c          157 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggcg gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagtagtgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctggctg ttgaatcgca
      301 tgatggaaat aagaaatact atgcagactc cgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggtgg atacggccat
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006105             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17890:15239
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006105
VERSION     KCXD01006105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17890:15239"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..307
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..307
     V_segment       8..230
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <225..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64587.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       246..256
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..307
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        308..>311
                     /gene="IGHG"
BASE COUNT           73 a           76 c           94 g           68 t
ORIGIN      
        1 acatgggggt ttccggaaaa accttcaccg aattatccat tcactgggtg cgacaggccc
       61 ctggaaaagg gcttgagtgg atgggaggtg ttgatcttgc atatgatgaa ataatggacg
      121 cagagaagtt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctata
      181 tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgcg gcgggccttg
      241 ggggatattt actgcttact gaatacctcg aattctgggg ccagggcgcc ctggtcaccg
      301 tctcctccgc c
//
LOCUS       KCXD01006106             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13645:5202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006106
VERSION     KCXD01006106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13645:5202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64588.1"
                     /translation="CTAHYSGSYYIDYFAYW"
     D_segment       446..465
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          120 a          123 c          151 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattt ccagctgtct ccacttgatg
       61 atcagcactg aacacaggag actcgccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gactcacctt cagtgactat
      241 gccatgagct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      301 agcacatata gaaattacgc gacagaatac gccgcatcgg tgaaaggcag attcaccatc
      361 tccagagatg attcaaggaa cacgctatat ctgcaaatga gcagcctgga aatagaggac
      421 acggccgtgt attattgcac tgcccactat agtggtagtt attacataga ctactttgcc
      481 tactggggcc agggagacct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006107             442 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:5512:11619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006107
VERSION     KCXD01006107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:5512:11619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    86..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        86..440
     V_segment       86..382
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <374..>409
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64589.1"
                     /translation="CARWEAASFDYW"
     D_segment       388..392
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>442
                     /gene="IGHG"
BASE COUNT           80 a          127 c          134 g          101 t
ORIGIN      
        1 acatgggggg gacatcctgt gtaagaacat gaagcacctg tggttcttcc tcctcctggt
       61 ggcagctccc agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc cagcagtggt
      121 gaagcctttg gagaccctgt ccctcacctg cgctgtctct ggtggctccg tcagcggtgg
      181 ttatggctgg agctggatcc gccaggcccc agggaaggga ctggagtgga ttgggagtat
      241 ctatggtcat agtggtagca cccgctacaa tccctccctc aagagtcgag tcaccatttc
      301 aaaagacacg tccaagaacc agttctccct gaagttgacc tctgtgaccg ccgcggactc
      361 ggccgtgtat ttctgtgcga gatgggaagc tgcctctttt gactactggg gccagggagt
      421 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006108             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14685:2674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006108
VERSION     KCXD01006108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14685:2674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..488
     V_segment       127..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64590.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       418..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>492
                     /gene="IGHG"
BASE COUNT          118 a          142 c          133 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccacctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggctacagc ttcgccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg gggggttttg ctagtatata tggtcaaata
      301 atacatacag agagattcca gggcagagtc accatgacag cggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctgacatct gaggacacgg ccgtgtatta ctgtgcggca
      421 gctgatagtg gttacccatt ttactacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctccg cc
//
LOCUS       KCXD01006109             397 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14195:11583
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006109
VERSION     KCXD01006109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14195:11583"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..395
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..395
     V_segment       20..313
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>364
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64591.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       321..332
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       352..395
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        396..>397
                     /gene="IGHG"
BASE COUNT           85 a          106 c          118 g           88 t
ORIGIN      
        1 acatgggggt gcccagtccc aggtccagct gatgcagtcc ggggctgagg tgaagaagcc
       61 tggggcctca gtgaagctct cctgcaaggc ttctggatac accttcagca tctttgccat
      121 caattgggtg cgacaggccc ctggacaagg gcttgagtgg atgggaggga tcatccctct
      181 tgttgggata acaaactacg tgcagaagtt ccagggcaga gtcaccatta ccgcggacac
      241 gtccacaagt atagcctaca tggagctgag cggcctaaga tctgaggaca cggccgtgta
      301 ttactgttcg agagggtcaa attacgagga tgcttccgat tacttttccg cctttgactc
      361 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006110             435 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:13621:10784
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006110
VERSION     KCXD01006110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 435)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:13621:10784"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..433
     V_segment       76..368
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>402
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64592.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       375..384
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       392..433
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>435
                     /gene="IGHG"
BASE COUNT           79 a          130 c          130 g           96 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggtagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagccttca
      121 gagaccctgt ccctcacctg cgctgtctct ggtggctcca tcagcggtta ctggtggggc
      181 tggatccgcc agtccccagg gaaggggctg gagtggattg ggtttttcgg tggtagtggt
      241 gggagcacct actacaaatc ctccctccag agtcgcgtca ccatttcaac cgacacgtcc
      301 aagaaccagt tctccctaat actgacctct gtgaccgccg cggacacggc cctctattac
      361 tgtgcgaggg ggaatatagc agcgactggc attgactact ggggccaggg actcctggtc
      421 accgtctcct cagcc
//
LOCUS       KCXD01006111             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6795:9874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006111
VERSION     KCXD01006111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6795:9874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..508
     V_segment       136..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <421..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64593.1"
                     /translation="CASNLRGNTFSYWRSFDFW"
     D_segment       442..448
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          108 a          131 c          154 g          117 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat ggagtctggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gagacttggt ccagccgggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagcta tggcatgacc
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtct catacattag tattggtggt
      301 ggtagtaaat actacgcaga ctccgtgaag ggccgattca ccatctccag agacaactca
      361 gagaaaacgc tctccctgca aatgaacagc ctgacacctg aggacacggc cgtttattac
      421 tgtgcgtcga acctacgtgg aaacaccttc agttactggc ggtcctttga cttctggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006112             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:25075:6778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006112
VERSION     KCXD01006112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:25075:6778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64594.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       406..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          104 a          147 c          131 g           93 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagccc ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggaaaca ccttcaccga attgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcccgca tatggtgaaa tgacattcca
      301 gggcagagtc ttcatgaccg aggacacgtc tacagacaca gcctacatgg agctgaccag
      361 cctgacatct gacgacgcgg ccgtctatta ctgtgcggtt ggccctagcg gcacttggaa
      421 ccactggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01006113             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:26985:6427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006113
VERSION     KCXD01006113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:26985:6427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64595.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          140 c          135 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacttg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatttctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006114             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21956:13719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006114
VERSION     KCXD01006114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21956:13719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64596.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          120 c          145 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaacgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagacctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccacttc agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006115             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13226:9344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006115
VERSION     KCXD01006115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13226:9344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64597.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          112 a          143 c          134 g           92 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaaatgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01006116             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16014:18219
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006116
VERSION     KCXD01006116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16014:18219"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64598.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          116 a          145 c          138 g           94 t
ORIGIN      
        1 acatggggga catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgacgtgaag aagcctgggg cctctgtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgagtta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttc agtggatggg aagtgttgat cctgcatatg gtgaaatgat
      301 aaacacagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtctatttct gtgcgagtgg
      421 ccctagcggc agctggaacg gctggtactt cgatatctgg ggccctggca cccctatcac
      481 cgtctcctca acc
//
LOCUS       KCXD01006117             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18993:5630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006117
VERSION     KCXD01006117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18993:5630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64599.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          108 a          145 c          137 g           88 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaaggt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaactgag
      361 cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggcccta ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006118             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10962:14989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006118
VERSION     KCXD01006118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10962:14989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..496
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64600.1"
                     /translation="CATADYGNSLDFW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>499
                     /gene="IGHG"
BASE COUNT          109 a          117 c          149 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag actgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtcgttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcatc
      301 tgatggaagt atgagtttct actcagactc tatgaaggac cgatttacca tctccagaga
      361 caattccaag aacatagtat atcttcaagt gaacaacctg aagttggagg acactgccgt
      421 ttattactgt gcgacagccg actacggtaa cagccttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01006119             337 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20849:11921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006119
VERSION     KCXD01006119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20849:11921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..335
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..335
     V_segment       5..270
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <263..>304
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64601.1"
                     /translation="CAREGISASGVDYW"
     D_segment       274..280
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       296..335
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        336..>337
                     /gene="IGHG"
BASE COUNT           59 a           97 c          110 g           71 t
ORIGIN      
        1 acatgggctg gtgaagcctt cggagaccct gtccctcacc tgcgctgtct ctggtggctc
       61 catcagcggt tactggtggg gctggatccg ccagtcccca gggaaggggc tggagtggat
      121 tgggtttttc ggtggtcgca atgggaacac gtactacaac ccctccctca agagtcgagt
      181 caccatttca ccagacacgt ccaaagagca gttctccctg aggctgaggt ctgtgaccgc
      241 cgcggacacg gccgtgtatt actgtgcgag ggaggggata tcagcgtcgg gggtcgacta
      301 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006120             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16936:13061
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006120
VERSION     KCXD01006120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16936:13061"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..425
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64602.1"
                     /translation="CTGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          108 a          123 c          154 g          106 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg gactgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagatgg tggagtctgg gggcggcttg gcaaaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tactggatga
      241 actgggtccg ccagactcca ggaaaggggc tggagtgggt ctcagctatt aattatgatg
      301 ggggtagcgc atactacgca gactccgtga agggccgatt caccatttcc agagacaact
      361 caaagagtac gctctccctg caaatgagca gcctgagagc ggaggacacg gccgtatatt
      421 actgtacggg cggggcatac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006121             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19389:11498
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006121
VERSION     KCXD01006121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19389:11498"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..434
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <433..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64603.1"
                     /translation="CTRLYSGNYRIMMFDSW"
     D_segment       445..454
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          117 a          124 c          152 g          123 t
ORIGIN      
        1 acatggggct gggagaggag acccagcctt gggatttcca gctgtctcca cttggtgatc
       61 agcactgaac acaggagact cgccatggag tttgtactga gctgggtttt ccttgttgct
      121 atactaaaag gtgtccagtg tgaggcgcag ttggtggagt ctgggggaga cttggtccag
      181 cctggcgggt ccctgagact ctcctgtgca gcctctggat tcagcttcac tgactatgcc
      241 atgagctggg tccgccaggc ttctgggaga ggactggagt gggttggcta tatgagaagt
      301 gaacatacca attacgcgac agagtacgcc gcatcggtga aaggcagatt caccatctcc
      361 agagatgatt caaagaacac cctatatctg caaatgagca gcctgaaaac cgaggacacg
      421 gccgtgtatt actgcacccg tctctatagt gggaactata gaattatgat gtttgactct
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006122             437 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:26019:9072
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006122
VERSION     KCXD01006122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 437)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 437)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:26019:9072"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    81..435
                     /note="immunoglobulin heavy chain variable region"
     V_region        81..435
     V_segment       81..374
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <366..>404
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64604.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       381..388
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       392..435
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        436..>437
                     /gene="IGHG"
BASE COUNT           96 a           97 c          135 g          109 t
ORIGIN      
        1 acatggggga gtaagagaaa cagtggatat gtgtggcagt ttctgacctt ggtgtctctc
       61 tgttcgcagg tgtccagtgt gaggtccagc tggtggagtc tggaggaggc ttggttcagc
      121 ctggggggtc cctgagactc tcctgtgcag cctctggatt cagtttcagc aactctggca
      181 ttcactgggt ccgccaggct ccaggggagg ggctggagtg ggtggcagtt atatcgtatg
      241 atgaaagtaa gacatactac gcagactctg tgaaggaccg attcaccatt tccagagaca
      301 attccaagaa catggtacat cttcaaatga acaccctgaa tttggaggac acggccgtat
      361 attactgtgt gagagattct tacggtagag gctttgacca gtggggccag ggagtcctgg
      421 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006123             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19515:6916
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006123
VERSION     KCXD01006123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19515:6916"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64605.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       437..444
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          119 a          113 c          149 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccatccg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccaatgtgag gtgcagctgg tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac gttcagtaac tatgggatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg aatgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01006124             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:18144:10438
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006124
VERSION     KCXD01006124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:18144:10438"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64606.1"
                     /translation="CVTDARGSGLDSW"
     D_segment       442..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          119 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtcc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg actcaccttc agtagctatg
      241 gcctccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtcacatcgt
      301 ctgatgggag taagaagtac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaatttcaa gaacatgctt gatcttcaaa tgaacagcct gaaattggaa gacacggccg
      421 tgtattactg tgtgacagat gcgaggggtt ccggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006125             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17137:14237
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006125
VERSION     KCXD01006125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17137:14237"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64607.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       438..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          108 c          154 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagttag ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt aatggcatgc
      241 actgggtccg ccaggttcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgttct
      421 actgtgtgag agactcttat gggagtggtt tggatgcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006126             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16061:9458
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006126
VERSION     KCXD01006126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16061:9458"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64608.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       427..436
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          133 c          146 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 ccccaggaaa agggcttgag tggatgggaa gtgttgatcc tgtatatggt gaaataattg
      301 tcgcagagaa tttccaggac agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg gaatctgagg acacggccgt gtattactgt gcgaaaggga
      421 ggagtggtgg tgtctggccg agctccttcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006127             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5691:10556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006127
VERSION     KCXD01006127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5691:10556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64609.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          114 c          151 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agcacctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tattttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtcaggggaa cgggatttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006128             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10854:11586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006128
VERSION     KCXD01006128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10854:11586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64610.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          121 c          151 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccatt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca ctaactatgg
      241 catgcactgg gtccgccagg ctccagggaa gggtctggag tgggtggcag ttatgtcgca
      301 tgatggaact aagaaattct acgcagactc tgtgaaggac cgattcacca tctccaggga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg agactggagg acgcggccgt
      421 ctattactgt gcgagaggag actacggtaa cagccttgac tactggggcc agggagtcct
      481 gctcaccgtc tcctcagcc
//
LOCUS       KCXD01006129             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15877:4572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006129
VERSION     KCXD01006129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15877:4572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64611.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       424..432
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          122 c          147 g          106 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg gccactctga
      121 ggtccagttg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca gtgtcaccga attatcgctt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgta aaaggtgaag aaattcacgg
      301 agaggagttc caggacagag tcaccatgac cgaggacccg tctacagaca cagcctacat
      361 ggagttgagc aacctgagat ctgaggacac ggccgtgtat tattgtgcga gtgggtttag
      421 tatctggtta ttttatgacg ttttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01006130             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15495:9683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006130
VERSION     KCXD01006130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15495:9683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64612.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          122 c          147 g          129 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgaactgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg agttcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006131             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11059:12791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006131
VERSION     KCXD01006131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11059:12791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..465
     V_segment       99..395
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64613.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       411..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..465
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           90 a          141 c          132 g          104 t
ORIGIN      
        1 atgggggttc tctgagagtc acggacatcc tgtgcaagaa catgaagcac ctgtggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcagctg caggggtcgg
      121 gcccagggct ggtgaagcct tcggagaccc tgtccctcac ctgcgctgtt tctggtgact
      181 ccatcaacag tggctactac tggagttgga tccgccaacc cccagggagg gggctggagt
      241 ggattgggtc tatcggtggt agtagtggca gcacctacta caacccctcc ctcaagagtc
      301 gagtcaccct ttcaaaagac acgtccagga accagttctc cctgaaactg agctctgtga
      361 ccgccgcaga cacggccgtt tattactgtg cgagaaaact tccaggtctc caactaaccg
      421 gtttcgattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006132             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:27179:14346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006132
VERSION     KCXD01006132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:27179:14346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..474
     V_segment       108..399
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64614.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       405..425
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           94 a          142 c          132 g          108 t
ORIGIN      
        1 acatgggggg ctgtctgaga gtcagggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca ggtcccagat gggtcctgtc ccagccgcag ctgcagctgc
      121 aggagtcggg cccaggactg gtgaaacctt cggagaccct gtccctcgcc tgcgttgtct
      181 ctggtggctc catcagcgat tactcctgga gctggatccg ccagccccca gggaagggac
      241 tggagtggat tgggaatatt gatgttcatc tagcgggccc caactacaac ccctccctca
      301 agagtcgagt cgccatttca aaagacacgt ccaagaatca gttctccctg aagctgagct
      361 ctgtgaccgc cgcggacacg gccgtatatt tctgtgcgaa acaatatagt ggtagttatt
      421 actactccca ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006133             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12661:11005
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006133
VERSION     KCXD01006133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12661:11005"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64615.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       439..444
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          111 a          108 c          152 g          121 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttat tgctatttta
      121 agaggtgtcc agtgtgaggt gcacctggtg gagtctgggg gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcatgt tcagtaacta tggcatccac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgt cagttatatc gtatgatgta
      301 actgtgaaat actacgcaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaatacgg tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattat
      421 tgtgtgagag atgtcagggg aacggggttt gacttctggg gccagggagt cctggtcacc
      481 gtctcgtcag cc
//
LOCUS       KCXD01006134             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14176:17959
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006134
VERSION     KCXD01006134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14176:17959"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..511
     V_segment       139..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64616.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       449..462
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          106 a          122 c          158 g          127 t
ORIGIN      
        1 acaggggggc tctgagacag gagtcttagg cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtggagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgtagcc tctggattca cctttggtga ttatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatccat tagaaacact
      301 ggtaaaatcg tatactacgc tgactccgtg aagggccgat tcatcatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agcctgagag tcgaggactc ggccgtctat
      421 tactgtacta gaattggcgt cggatctcta gcaccggctg gtgaatactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006135             403 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:7928:13563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006135
VERSION     KCXD01006135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 403)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 403)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:7928:13563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..401
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..401
     V_segment       71..334
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <326..>370
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64617.1"
                     /translation="CARTSGGWSPYFDFW"
     D_segment       337..352
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       355..401
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        402..>403
                     /gene="IGHG"
BASE COUNT           78 a          118 c          114 g           93 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      121 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      181 gattggacgt gtctctggtg gtggtgggaa caccgactac aacccctttt tcaagagtcg
      241 agtcaccttt tcaagagaca cgtccaggaa ccagatctcc ctggagatga attatgtgac
      301 cgccgcggac acggccgtgt attactgcgc gagaactagc ggtggctggt ccccctactt
      361 tgacttttgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006136             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:21732:12398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006136
VERSION     KCXD01006136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:21732:12398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64618.1"
                     /translation="CARELSPYDYVWSDFYSYYFDYL"
     D_segment       412..418
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           95 a          147 c          133 g          114 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggc atatcagtgg gactagtggg agcaccgact acaacccctc cctcaaaagt
      301 cgagtcacca tttcaacaga cacgtccaag agtcacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagc tttcccccta cgactatgtt
      421 tggagtgatt tttactctta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01006137             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16988:4769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006137
VERSION     KCXD01006137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16988:4769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64619.1"
                     /translation="CARGRSGGVWPNYFDYW"
     D_segment       426..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          133 c          146 g          101 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 ccctggaaga gggcttgagt ggatgggagg tgttgatcct gtgtatggtg aaattattgt
      301 cgcagagaat ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctgg aatctgcgga cacggccatc tattactgtg cgagagggag
      421 gagtggtggt gtctggccga actactttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01006138             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:6440:22116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006138
VERSION     KCXD01006138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:6440:22116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64620.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       439..451
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          109 c          156 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag taacggcatg
      241 cactgggtcc gccaggttcc agggaagggg ctggagtggg tggcagtgac atcgtttgat
      301 gaaagtaaga aatactacgc agactctgtg aaggaccgat tcaccgtctc cagagacaat
      361 tccaagaaca tggtatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagactctta tggaagtggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006139             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22771:16370
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006139
VERSION     KCXD01006139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22771:16370"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64621.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          130 c          148 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gatctggctt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggagga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcattg ggtccgccag gctccaggga aggggctgaa atgggtctca tctattagta
      301 gtggtggtct cacatactac gcagactccg tgaagggccg atttgccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag cgctgaggac acggccgtat
      421 attactgtgc gaaaggaggt agcagctctt tctattggta cttcgatatc tggggccctg
      481 gcaccccagt gaccatctcc tcagcc
//
LOCUS       KCXD01006140             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10913:14362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006140
VERSION     KCXD01006140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10913:14362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64622.1"
                     /translation="CARGTGAILVYFDSW"
     D_segment       434..440
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          121 c          153 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgaga tacaactggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcaggctc tggattcagc ctcagacact attatatgac
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtgatgg
      301 gagtggcaca tactatgcag actccgtgaa ggacagattc accatctcca gagacaacgc
      361 caagaacaca ctgtctcttc aaatggacag cctgacagct gaggacacgg ctgtctatta
      421 ctgtgcgagg gggactgggg cgattcttgt gtattttgac tcttggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006141             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16180:14832
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006141
VERSION     KCXD01006141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16180:14832"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64623.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       444..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>503
                     /gene="IGHG"
BASE COUNT          112 a          115 c          152 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagtctctgg attcaccttc aggaattatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ttgatggaat taagagttat tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa gaacatgcta aatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgagacgc ccttggaacg ctgactactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01006142             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7096:12854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006142
VERSION     KCXD01006142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7096:12854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64624.1"
                     /translation="CARWGTPFDFW"
     D_segment       401..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          136 c          132 g          103 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga agcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcttg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga ggccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tagctccatc aacagtggtt atgcctggag ttggatccgc cagcccccag ggaaggggct
      241 ggagtgggtt gggcatttct atgatagtag tgggaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aggacacgtc caagaaccaa ttctccctga agctgacctc
      361 tgtgaccgcc gcggacacgg ccgtctattt ctgtgcgaga tgggggaccc cctttgactt
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006143             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9780:8652
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006143
VERSION     KCXD01006143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9780:8652"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64625.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          120 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttc
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg cagcctctgg attccccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatgaaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatacta tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006144             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:9858:13222
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006144
VERSION     KCXD01006144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:9858:13222"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64626.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       446..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          117 c          149 g          128 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggcgcagctg gtggaatctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcggcc tctgaattcc cctttagcag ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggagtggg tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtgcaaggg ggatagataa ctaccactat agtgatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006145             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11370:16367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006145
VERSION     KCXD01006145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11370:16367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64627.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       262..267
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           73 a           87 c           85 g           74 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttccccttca ctacctctgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctcgag tggctgacag ttatatcgtt
      121 tgatgaaact aaggaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      181 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      241 gtattactgt gcgagagatt cttacggccg aggctttgac tcctggggcc agggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006146             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15873:14929
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006146
VERSION     KCXD01006146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15873:14929"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    96..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        96..453
     V_segment       96..388
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64628.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       396..404
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           80 a          139 c          135 g          101 t
ORIGIN      
        1 acatggggct gagagtcacg gacctcctgt gcaagaacat gaagcacctg tggttcttcc
       61 tcctcctggt ggtagctccc agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc
      121 caggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct ggtggctcca
      181 tcagcggtta ctggtggggc tggatccgcc agtcgccagg gaaggggctg gagtggattg
      241 ggtttttcgg tggttatggt gggaacacct actacaaccc ctccctccaa agtcgagtca
      301 ccatttcaac cgacacgtcc aagacccagt tctccctgat tctgacctct gtgaccgccg
      361 cggacacggc cctctatttc tgtgcgaggg ggaacatagc agcgactggc attgactact
      421 ggggccaggg actcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006147             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:3923:16348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006147
VERSION     KCXD01006147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:3923:16348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64629.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           95 a          147 c          145 g          111 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc cttgtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtctcc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006148             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14822:4989
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006148
VERSION     KCXD01006148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14822:4989"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    129..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        129..483
     V_segment       129..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64630.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       422..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          112 a          147 c          136 g           90 t
ORIGIN      
        1 acatggggag agagcatcac acaacaacca catccctccc ctacagaagc cccagagcac
       61 agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg
      121 cccactctga ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag
      181 tgagggtctc ctgcaaggtt tccggctaca ccttcaccga attatccata cactgggtgc
      241 gccaggcccc tggaagaggg cttgagtgga tgggaagtgt tgatcctcta tatggcgaaa
      301 tgaagttcca gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg
      361 aactgagtag cctgacatct gaggacacgg ccgtgtatta ctgtgcgact ggccctagcg
      421 gcacctggaa cgcctggtac ctcgatatct ggggccctgg caccccaatc accatctcct
      481 cagcc
//
LOCUS       KCXD01006149             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14406:15205
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006149
VERSION     KCXD01006149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14406:15205"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64631.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       410..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          131 c          139 g          104 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagcctccgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgggtctat cagaagtagt tactgcagct ggatccgcca gaccccaggg aagggactgg
      241 agtggattgg gtatatctat gggagtgata gtagtaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtg ctccctgaag ttgagcgctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc gggtatagaa gtggttgcct
      421 acagcattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006150             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:25964:8048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006150
VERSION     KCXD01006150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:25964:8048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64632.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagta ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcattcactg ggtccgccag actccgggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagacatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggtg tattttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgcgagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006151             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11854:3282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006151
VERSION     KCXD01006151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11854:3282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64633.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          104 a          128 c          158 g          110 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcaatacc tatgctatac
      241 actgggtccg ccaggctccc gggaaggggc tggactgggt ctcagccatt agtagtggtg
      301 ggcgcacata ctacgcagac tccgtgaagg gccgagtcac catctccaga gacaactcaa
      361 agaacacggt ctccctgcaa atgaacagcc tgggagctga ggacacggcc gtgttttact
      421 gtgcgagagg ggagacagct tcagtttact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006152             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14979:19692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006152
VERSION     KCXD01006152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14979:19692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..494
     V_segment       104..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64634.1"
                     /translation="CARDAGFGETILVVDINMFPHFDSW"
     D_segment       416..438
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT           99 a          141 c          140 g          116 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgtg atgtctctgg
      181 tgcctccatc agtacttcct ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gttatagtgg tagtttttac tccaacccct ccctcaacag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccagttc gccctgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgcgagat gccgggtttg gggaaacgat
      421 attagtagtc gatattaata tgttccccca ctttgactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006153             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15857:18417
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006153
VERSION     KCXD01006153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15857:18417"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64635.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       443..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          122 a          115 c          152 g          125 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcaatg agtatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg attggctata ttagaagcaa
      301 atataacgat tacgcgacag aatatgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacac tatatctgca gatgagcagc ctgaaaaccg aggagacggc
      421 cgtgtattac tgcacccgtc tctatagtgg gaactataga attatgatgt ttgactactg
      481 gggccaggga gtcctggtca gtgtctcctc agcc
//
LOCUS       KCXD01006154             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7414:20008
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006154
VERSION     KCXD01006154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7414:20008"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64636.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          110 a          118 c          156 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cacaaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggttccct gagactctcc tgcgcagcct ctggattcag cttcaattat tactacatga
      241 gctgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt aatagtggtg
      301 gggaaagcac atactctgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac gctatatctt gaaatggaca gcctgagaac tgaggacacg gctgtctatt
      421 attgtgtgag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006155             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20011:11258
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006155
VERSION     KCXD01006155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20011:11258"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64637.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          104 a          145 c          135 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg agtatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa aggccttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 gcagcctgag atctgaggac acggccatgt atttctgtgc gatcggccct agcggcagct
      421 ggaacgcctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01006156             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14819:14935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006156
VERSION     KCXD01006156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14819:14935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64638.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       421..429
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          111 a          142 c          134 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcaactac aggcacccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtg tattattgcg cgattggccc tagtggcaga
      421 tggaacgact ggtccttcga catctgggga cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01006157             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15406:9663
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006157
VERSION     KCXD01006157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15406:9663"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64639.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          115 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgctg
      121 ctgttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006158             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5501:6134
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006158
VERSION     KCXD01006158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5501:6134"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64640.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       431..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          110 a          143 c          151 g           98 t
ORIGIN      
        1 atgggggcat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccgctc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaatata
      301 cgcagagagg ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagt agcggctggt ccagcctctt caccggtttg gattcctggg gccgaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006159             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12948:15157
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006159
VERSION     KCXD01006159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12948:15157"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64641.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          113 c          153 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc aatcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gtgagagatg tcaggggaac ggggtttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006160             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17429:6147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006160
VERSION     KCXD01006160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17429:6147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64642.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       447..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          118 c          157 g          115 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagtg cagctggtgg agtctggggg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtggctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtggc ggttatagcc
      301 aatgatggaa ctaagaaata ctacgcagac tctgtgaagg accgattcag catttccaga
      361 gacaactcca agaacatact gtatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctactact gtgcgacaga tgcgtttggt agcgggattg actactgggg ccggggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006161             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:24299:7109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006161
VERSION     KCXD01006161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:24299:7109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64643.1"
                     /translation="CATSSSGSWLYWYFDVW"
     D_segment       419..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          114 a          140 c          137 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcagcga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctgta tatggtgaga tgattgacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggtcctgagc agcctgagat ctgaggacac ggccgtctat tactgtgcga catcatccag
      421 cggcagttgg ctatactggt acttcgatgt ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01006162             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16221:20312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006162
VERSION     KCXD01006162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16221:20312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64644.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          118 c          150 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttcctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattccc cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtctgtaatt tcgtctgatg
      301 aaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacat actatttctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006163             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13375:3312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006163
VERSION     KCXD01006163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13375:3312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64645.1"
                     /translation="CARYEGAAAGTWFFDYW"
     D_segment       404..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          142 c          131 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc aatcattact ggaactggat ccgccagccc cccgggaagg gactggagtg
      241 ggttgggtct ctctatggtg ctactgggag caccaactat aatccctccc tcaagagtcg
      301 agtcagcatt tcaacagaca tgtccaagaa ccaattttcc ctgaaactga cctctgtgac
      361 cgccgcggac accgccgtct attactgtgc gagatatgag ggggcggcag ctggaacctg
      421 gttctttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006164             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18673:16303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006164
VERSION     KCXD01006164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18673:16303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64646.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          120 a          142 c          127 g           99 t
ORIGIN      
        1 acatggggga acacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga accaccttca ccgaattatc cctgcactgg gttcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gttttaatcc tatatatggt gaaattttac
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg acatctgagg acacggccgt gtattactgt gcggcagctg
      421 atagtggtta cccattttac tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01006165             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18589:15029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006165
VERSION     KCXD01006165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18589:15029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64647.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          117 c          151 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg acctgggttt tccttgttgc
      121 tattttagga ggtgtccggt gtgaggtgcg actggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcag ttatttcgtc
      301 tgatggaagt aagaaatact acgcaaactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006166             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:28393:13494
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006166
VERSION     KCXD01006166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:28393:13494"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64648.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          116 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 ccgcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccgga gtgaggtgcg actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catgcactgg gtccgtcagg ctccagggaa ggggctggag tgggtggctg ttatttcgtc
      301 tgatggaagt aagaaatact acgcaaactc tctgagggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006167             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:7580:7424
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006167
VERSION     KCXD01006167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:7580:7424"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64649.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          121 c          146 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggttc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagacatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattcaa tatcttcaca tgaacaacct gaaattggag gatacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006168             307 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14186:17487
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006168
VERSION     KCXD01006168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 307)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14186:17487"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..305
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..305
     V_segment       8..233
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>274
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64650.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       250..260
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       262..305
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        306..>307
                     /gene="IGHG"
BASE COUNT           66 a           92 c           85 g           64 t
ORIGIN      
        1 acatgggaag acttctggat acagctttac cgattactgg atcagttggg tgcgccagat
       61 gcccgggaaa ggcctggagt ggatgggaat gatctatcct agtgattctg atcccagata
      121 cagcccgtcc ttccaaggcc aggtcaccat ctcagccgac aggtccatca gcaccgccta
      181 cctggagtgg ggcagcctga aggcctcgga caccgccacg tattactgtg cgagagctgg
      241 acgctacacc tacagttacc cctttgacta ctggggccag ggagtcctgg tcaccgtctc
      301 ctcagcc
//
LOCUS       KCXD01006169             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19063:16588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006169
VERSION     KCXD01006169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19063:16588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64651.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       448..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          116 c          161 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctccgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga gtgggtggca ctgatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatcctg tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagagggta ctggtggtgc ggaggacttt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006170             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11503:16112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006170
VERSION     KCXD01006170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11503:16112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64652.1"
                     /translation="CARWSAANFDSW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           85 a          133 c          137 g          102 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcctagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatccgc agtggttatg gctggagctg gatccgccag tccccaggga aggggctgga
      241 gtggattgga tgtgtctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaatgg acacgtccaa gaaccagttc tccctggagc tgaggtctat
      361 gaccgccgcg gacacggccg tgtatcactg tgcgagatgg tcggcagcca actttgactc
      421 ctggggtcag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006171             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19800:14990
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006171
VERSION     KCXD01006171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19800:14990"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64653.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          112 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtccggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcatgttc agtaactatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagggat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01006172             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7888:18660
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006172
VERSION     KCXD01006172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7888:18660"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64654.1"
                     /translation="CAGGAYANLDYW"
     D_segment       444..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          125 c          154 g          110 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gaactgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aaatggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctgga gtgggtctca gctcttaatt
      301 atgatgggga tagtacatac tacgcagact ccgtgaaggg tcgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgcacagcct gagagaggat gacacggccg
      421 tatatttctg tgcgggcggg gcgtacgcta acctcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006173             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16442:19166
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006173
VERSION     KCXD01006173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16442:19166"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..498
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64655.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       443..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>502
                     /gene="IGHG"
BASE COUNT          110 a          114 c          154 g          124 t
ORIGIN      
        1 catggggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agtctctgga ttcaccttca ggaattatgg
      241 catgcactgg gttcgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgtt
      301 tgatggaatt aagagttatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcaaag aacatgctaa atcttcaaat gaacgacctg aaattggagg acacggccgt
      421 gtattactgt gcgagacgcc cttggaacgc tgactacttt gactactggg gccagggagt
      481 cctggtcacc gtctcctccg cc
//
LOCUS       KCXD01006174             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8615:20923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006174
VERSION     KCXD01006174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8615:20923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64656.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       432..436
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          123 c          156 g          116 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcaa cttcaattac tactacatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt aacagtggtg
      301 gtgatagcac atactatgcg gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtttctt caaatggaca gcctgagagc tgacgacacg gctgtctatt
      421 actgtgcgag agtggtgggt ggtgccgcag gatacttcga cttctggggc cagggcgccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006175             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13777:17518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006175
VERSION     KCXD01006175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13777:17518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..477
     V_segment       111..402
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64657.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       408..428
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           97 a          142 c          131 g          109 t
ORIGIN      
        1 acatggggaa atgctgtctg agagtcaggg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcaggtccca gatgggtcct gtcccagccg cagctgcagc
      121 tgcaggagtc gggcccagga ctggtgaaac cttcggagac cctgtccctc gcctgcgttg
      181 tctctggtgg ctccatcagc gattactcct ggagctggat ccgccagccc ccagggaagg
      241 gactggagtg gattgggaat attgatgttc atctagcggg ccccaactac aacccctccc
      301 tcaagagtcg agtcgccatt tcaaaagaca cgtccaagaa tcagttctcc ctgaagctga
      361 gctctgtgac cgccgcggac acggccgtat atttctgtgc gaaacaatat agtggtagtt
      421 attactactc ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006176             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:23864:15144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006176
VERSION     KCXD01006176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:23864:15144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64658.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       415..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          109 a          146 c          138 g           88 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccct caccgaagtg tccactcact gggtgcgaca
      241 ggcccccgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgaa
      301 ggtccagggc agagtcacca tgaccgagga cacgtccaca gacacagcct acatggaact
      361 gagcagccta agatctgagg acacggccgt gtattactgt gcgattggcc ctaccggcag
      421 gtggaacggc tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01006177             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16609:18567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006177
VERSION     KCXD01006177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16609:18567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64659.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       441..449
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          113 c          149 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgcgatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccgga
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtttct atggcttgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagtaattt cgaatgatga
      301 aaataacaaa tactacgcag actctgtgaa ggaccgattc accatttcta gagacaattc
      361 catgaacatg ctatttcttc aaatgaacaa cctgaacttg gacgacacgg ccgtctatta
      421 ctgtgtgaga gatgatttag gcagcggctt agggtcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006178             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:27077:12822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006178
VERSION     KCXD01006178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:27077:12822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..496
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64660.1"
                     /translation="CATADYGNSLDFW"
     D_segment       440..451
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>499
                     /gene="IGHG"
BASE COUNT          113 a          120 c          146 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tcggggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 cttgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaaat atgaaatact acgcagactc tatgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaagt gaacaacctg aaattggaag acactgccgt
      421 ttattactgt gcgacagccg actacggtaa cagccttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcaacc
//
LOCUS       KCXD01006179             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19396:15261
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006179
VERSION     KCXD01006179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19396:15261"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..491
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64661.1"
                     /translation="CARERCNTRVCAGFFDYW"
     D_segment       425..430
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          143 c          140 g           97 t
ORIGIN      
        1 acatggggga caaaacaacc acatccctcc tctaaagaag cccctgggag cacagctcat
       61 caccatggac tggacctgga ggctcctctt tgtggtggca gcagctacag gtggccagtc
      121 ccaggtccag gtggtgcagt ccggggctga agtgaagaag cccggggcct cagtgaaagt
      181 ttcctgcaag gcctctggat tcaccctcga caactttggc atcaactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagt gaccatcccc cttgttggga taattaacta
      301 cgcagagaag ttccagggca gagccacact taccgcggac acgtccacaa acacagccta
      361 catggaactg accggcctga tatctgagga cacggccatc tattactgtg cgagagaacg
      421 ctgtaatact cgtgtttgcg ccggcttctt tgactactgg ggccagggag tcccggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006180             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21766:10443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006180
VERSION     KCXD01006180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21766:10443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64662.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          116 a          143 c          129 g           89 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggaaaag gacttgagtg gatgggaggt gttcatcctg aatatgggaa agtagactac
      301 acacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga gacagtctac
      361 atggagctga gcagcctgag atctgaggac acggccactt attactgtgt gacagtgggt
      421 ccctaccatt actttgacta ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006181             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11245:19684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006181
VERSION     KCXD01006181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11245:19684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64663.1"
                     /translation="CARDESSINYPFDFW"
     D_segment       409..415
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           91 a          139 c          129 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagt atctgtggct
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcaac ttcaggagtc
      121 gggcccagga caggtgaggc cttcagagac cctgtccctc acctgcgctg tctctcgtgg
      181 ctccatcagt ggttacaggt ggagctggat tcgccagccc ccagggaagg gactggagtg
      241 gattggacgc atctctggta gtggtgggag caccacctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaataa acggttttcc ctgaagatga gctctgtgac
      361 cgccgcggac acggccgtct atttctgtgc gagagatgag agctccatta actacccttt
      421 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006182             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10536:5179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006182
VERSION     KCXD01006182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10536:5179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..479
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64664.1"
                     /translation="CARADYGSSLLPEYFDFW"
     D_segment       409..421
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>483
                     /gene="IGHG"
BASE COUNT           96 a          151 c          131 g          105 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag
      121 ctgcaggagt cgggcccagg actggtgagg ccttcggaga ccctgaccct cacctgcgct
      181 gtctctggtg gctccatcag cactaacttc tggaactgga tccgccagcc cccagggaag
      241 ggactggagt ggattggacg tatctctggt attgctggga ataccgacta caatccctcc
      301 ctcaagagtc gagtctccat ttcaaaagac acgtccaaca accagttcca cctgcacctg
      361 acctctgtga ccgccgcgga cacggccgta tattactgtg cgagagcgga ctacggtagc
      421 agcttgctcc ctgaatactt cgatttctgg ggccagggcg ccctggtcac cgtctcctcc
      481 gcc
//
LOCUS       KCXD01006183             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:3846:12120
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006183
VERSION     KCXD01006183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:3846:12120"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64665.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       421..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          110 a          142 c          141 g          103 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggtctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat ccaccttcac cgagttatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgctcct ctatatggtg aaatgatgca
      301 cgcagacaac ttccagggca gagtcacctt gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgacga cacggccgtg tattactgtg cgcgtgggcc
      421 tattacaatt tttggcgtac ttattacggg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006184             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11497:13656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006184
VERSION     KCXD01006184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11497:13656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64666.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       434..445
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          116 c          151 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cattgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact atggcatgca
      241 ctgggtccgc caggctccag ggaagggtct ggagtgggtg gcagttatgt cgcatgatgg
      301 aactaagaaa ttctacgcag actctgtgaa ggaccgattc accatctcca gggacaattc
      361 caagaacatg gtatatcttc aaatgaacaa cctgagattg gaggacgcgg ccgtctatta
      421 ttgtgcgaga ggagactacg gtaacagcct tgacttctgg ggccagggag tcctgctcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006185             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5156:7191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006185
VERSION     KCXD01006185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5156:7191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64667.1"
                     /translation="CVRDGYGSGLDAW"
     D_segment       447..456
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          108 c          161 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcggggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agcacgtttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttataacga
      301 atgatggaag taagaattac tacgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaatatggta tatattcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gggtacggta gtggtttgga tgcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006186             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16957:5481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006186
VERSION     KCXD01006186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16957:5481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64668.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          123 a          140 c          136 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaggtggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01006187             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8035:11646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006187
VERSION     KCXD01006187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8035:11646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64669.1"
                     /translation="CVRYEDESINYHFDNW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           97 a          139 c          125 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctccaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgaca actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006188             428 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5119:8872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006188
VERSION     KCXD01006188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5119:8872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    166..426
                     /note="immunoglobulin heavy chain variable region"
     V_region        166..426
     V_segment       166..343
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <342..>395
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64670.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       357..368
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..426
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        427..>428
                     /gene="IGHG"
BASE COUNT          108 a           95 c          125 g          100 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccagt tggcgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccggtgtg aggtgcagct ggtggagtct gggggaggct tctgggaaag
      181 gactggagtg ggttggctat attagaacca aatataacaa ttacgcggca gaatacgccg
      241 catcggtgaa aggcaggttc accatctcca gagatgattc aaagaacacg atatatctgc
      301 aaatgagtag cctgaaaacc gaggacacgg ccgtgtatta ctgcaccaca tggagatatt
      361 actatagtac tggttacccc acctttgact actggggcca gggagtcctg gtcaccgtct
      421 cctcagcc
//
LOCUS       KCXD01006189             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13263:10528
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006189
VERSION     KCXD01006189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13263:10528"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64671.1"
                     /translation="CARGPSAWSVGWDYW"
     D_segment       415..421
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           85 a          141 c          137 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 tctccatcag cactcactac ttgacctggg tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agcagtggga gcaccgacta caacccctcc ctcaacagtc
      301 gagtcaccat ttcaagagac acgtccaaga atcagttctc cctgaagctg aggtctgtga
      361 ctgtcgcgga cacggccgtc tatttctgtg cgagaggacc tagcgcctgg tccgtggggt
      421 gggattactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006190             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13528:10549
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006190
VERSION     KCXD01006190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13528:10549"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64672.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       395..403
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          136 c          130 g          114 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgttcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccaaatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cctcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactcct ggagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gatcggttat gtctatggtg atagtgggaa caccgaatac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagact cgtccaagaa tcagttttcc ctgaagctga gttctgtgac
      361 cgccgcggac accgccgtgt atcactgtgc gagatacagt tacggttcca actacttctt
      421 tgggttcttt gactattggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006191             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:17227:14977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006191
VERSION     KCXD01006191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:17227:14977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    152..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        152..325
     V_segment       152..250
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <244..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64673.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       265..276
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..325
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           73 a          107 c           88 g           59 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gagggcagag tcaccatgac cgaggacacg
      181 tctacagaca cagcctacat ggagctgagc agcctgagat ctgaggacac ggccgtctat
      241 tactgtgcga ttggccctag tggcagctgg aacgactggt ccttcgacat ttggggacct
      301 ggcaccccaa tcaccgtctc ctcagcc
//
LOCUS       KCXD01006192             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16130:13105
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006192
VERSION     KCXD01006192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16130:13105"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64674.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          116 c          154 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgtta
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcct
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacctgcta tatcttcaaa tgaacagcct gaaattggag gacacggcca
      421 catactactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcagcgt ctcctcagcc
//
LOCUS       KCXD01006193             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24767:10124
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006193
VERSION     KCXD01006193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24767:10124"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64675.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          124 c          148 g          107 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgcttcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgagg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtatct ggttatttta tgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006194             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21353:19507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006194
VERSION     KCXD01006194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21353:19507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64676.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       444..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          116 a          110 c          152 g          120 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggttcac ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgaa gcctctggat tcaccttcag tagttatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcatat
      301 gatgtaagta agaaatacta cgcagacgct gtgaaggacc gattcaccat ttccagagac
      361 aattccaaga acacgctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattactgtg ggagagatga taatggggtg cttatcgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006195             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:12872:10298
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006195
VERSION     KCXD01006195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:12872:10298"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64677.1"
                     /translation="CARWSAANFDYW"
     D_segment       405..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           92 a          133 c          137 g           98 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga cctcctgggc aagaacatga ggcatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg atgtctctgg
      181 gggctccatc agcagtggtt atggctggag ctggatccgc cagcccccag ggaaggggct
      241 ggagtggatt gggtgtatct acgatagtag tggaaacacc tactacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccag ttctccctga agctgaggtc
      361 tatgaccgcc gcggacgcgg ccgtgtatta ctgtgcgaga tggtcggcag ccaactttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006196             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:9464:4346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006196
VERSION     KCXD01006196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:9464:4346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    82..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        82..463
     V_segment       82..379
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <370..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64678.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       385..402
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          105 a          136 c          118 g          106 t
ORIGIN      
        1 aatgggggaa tcctgtgctc caccatggac acgctttgct acacactcct gctactgacc
       61 gtcccgtcct gggccttgtc ccaggtcacc ttgaaggagt ctggtcctgc gctcgtgaaa
      121 cccacacaga ccctcacgtt gacctgcacc ttctctgggt tctcaatcag ctctactgga
      181 agaggtgtgg gctggatccg tcagccccca gggaaggccc tggaatggct tgcaaccatt
      241 tattggaatg atagtaaata ctacagcaca tcgctgaaga gcaggctcac cgtctccaag
      301 gacacctcca aaaaccaggt ggttctgaca atgaccaaca tggaccctgt ggacacagcc
      361 aaatattact gtgcacggga ttactgtagt gggatttact gcgatgtaaa tgggcactac
      421 tttgacctct ggggccaggg agtcctggtc gccgtctcct cagcc
//
LOCUS       KCXD01006197             441 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:14068:4977
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006197
VERSION     KCXD01006197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 441)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:14068:4977"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..439
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..439
     V_segment       76..369
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>408
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64679.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       373..380
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..439
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        440..>441
                     /gene="IGHG"
BASE COUNT           88 a          126 c          126 g          101 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc ttctcctggt ggcagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacctg cggtgtctct ggtgactcca tcagtagtag ctactggaac
      181 tggatccgcc agcccccggg gaagggactg gagtggattg ggtatatctc tggtgcttat
      241 gggagcacca gctacaatcc ctccctcaag agtcgagtca ccatttcaac agacacgtcc
      301 aagaaccagt tttccctgag gctgagttct gtgaccgccg cggacaccgc cgtgtattac
      361 tgtgtgagat atgaggatga gtccattaac taccactttg actactgggg ccagggagtc
      421 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006198             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:10625:11293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006198
VERSION     KCXD01006198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:10625:11293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64680.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          139 c          127 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg cgcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006199             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:16142:18434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006199
VERSION     KCXD01006199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:16142:18434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64681.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          109 a          138 c          134 g          104 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag tcccaggtcc
      121 gcctggtgca gtccgggact gaggtgaaga agcctggggc ctcagtgaag atttcctgcg
      181 gggcttctgg tttcaccctc gacacctatg gtatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttattgg tatcaccaac tacgcagaaa
      301 actctcaggg cagactcaca ataaccgcga acacgtccac aaatacagtc tatatggaac
      361 tgagcagtct gagatctgag gacacggcca tctattactg tgcgagagaa tactgtactt
      421 ctagtacttg cgccgggttc cttgactact ggggccaggg agccctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01006200             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8790:10432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006200
VERSION     KCXD01006200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8790:10432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64682.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       441..446
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          107 a          114 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggcgg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgta gcctctggat tcaccttcag tcgtagtggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt ggctggctgt tgagtcgcat
      301 gatggaaata agaaatacta tgcagactcc gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatggtata tcttcaaatg aacaacctga aattggtgga tacggccatg
      421 tattactgtg tgagagatgc ctacgggggc ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006201             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18179:7018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006201
VERSION     KCXD01006201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18179:7018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64683.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..451
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          120 c          152 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgct
      121 gctattttaa gaggtgtcca gtgtgaggtc cacctggtgg aatctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaccttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatggaa gtaagaaata ctacgcagac tctttgaaag accgattcac catatccaga
      361 gacaactcca agaacatagt atatcttcaa ctgaacagcc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagaga tgtgtatggc tcggggcttg actactgggg ccagggagtc
      481 ctgctcaccg tctcctcagc c
//
LOCUS       KCXD01006202             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6060:7076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006202
VERSION     KCXD01006202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6060:7076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..498
     V_segment       135..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64684.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       442..447
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          126 c          151 g          118 t
ORIGIN      
        1 acatggggga gaggagccca gccccagaat tcccaggtgt ttctgttcgg cgatcagcac
       61 taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg cagttaatgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actctcctgc gcagcctctg gattcagctt cagttactac tacatgagct
      241 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaac gctggtgggg
      301 ataccacata ctctgcagac tccgtgaagg gcagatccac catctccaga gagaacgcca
      361 agaacacact gcatcttcaa atggacagcc tgagacctga ggacacggct gtctattact
      421 gtgtgagaga tcgacgtgtt cagtcgttat cctggttcga tgtctggggc ccgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006203             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8440:4279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006203
VERSION     KCXD01006203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8440:4279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64685.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       273..285
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           74 a           83 c           98 g           77 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgcagtctct ggattcacct
       61 tcagtagctt tggcatgcac tgggtccgcc aggctccagg gaaggggctg gaatgggtgg
      121 cagtgacgtc ctatgatgga agttggaact actacggaga ctctgtgaag gaccgattca
      181 ccatctccag agacaattcc aagagcctgc tatatcttca aatggacaac ctgaacttgg
      241 aggacacggc cgtatattac tgtgcgagag gggaatacag taactctatt gacttctggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006204             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:16711:7220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006204
VERSION     KCXD01006204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:16711:7220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64686.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       404..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           89 a          142 c          128 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctgctga
      181 ctccatcacc agtagcttct ggaactggat ccgccagccc ccagggaggg ggctggagtg
      241 gattggctat atctctggtg ctactgggag ttccagctac aacccctccc tcaagagtcg
      301 agtctccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gacgatgatt acggttctta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006205             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14645:19664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006205
VERSION     KCXD01006205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14645:19664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64687.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          142 c          132 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctcaggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccttt tcaagagaca cgtccaggaa ccagttctcc ctgcagctga attatgtaac
      361 cgccgcggac acggccgtgt attactgtgc cagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006206             337 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:24876:15899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006206
VERSION     KCXD01006206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:24876:15899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..335
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..335
     V_segment       9..265
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <257..>304
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64688.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       276..282
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..335
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        336..>337
                     /gene="IGHG"
BASE COUNT           71 a           98 c           94 g           74 t
ORIGIN      
        1 acatggggag ccttcggaga ccctgtccct cacctgcgct gtctctggtg gctccatcag
       61 agagtactat tggagctgga tccgccaggc cccagggaag ggactggagt ggattggcta
      121 catctatggt aacattggga gcaccagcta taacccgtcc ctccagagtc gagtcaccgt
      181 ttcaatagac acgtccaaga atcacttctc cctgaagttg acgtctgtga ccgccgcgga
      241 cacggccgta tatcactgtg cgagacatct ctattcctgg aaagggaagt ggatcgatgt
      301 ctggggcccg ggagtcctga tcaccgtctc ctcagcc
//
LOCUS       KCXD01006207             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9678:15425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006207
VERSION     KCXD01006207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9678:15425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64689.1"
                     /translation="CATGRIGSSGWSTLFTGLDSW"
     D_segment       427..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          110 a          152 c          146 g           94 t
ORIGIN      
        1 acatggggac cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaggcac cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattaccc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggctgggagt tgttgatcct gtcaatgctg aagaaataca
      301 cgcagagagg ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 catggacttg agcactctca catctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agcggctggt ccaccctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006208             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:21820:17809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006208
VERSION     KCXD01006208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:21820:17809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64690.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       440..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          117 a          121 c          159 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagg cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttggtct gacctgggtt ttccttgttg
      121 gtattttgaa aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggctc
      181 agcctggggg gtccctgaga ctctcctgtg cagcgtctgg gttcaccttc agtagctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gccatatcat
      301 ttgatggaag taagaaaaac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa caacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatactactg ttcgagggag tggatacagt gggcacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006209             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17424:4725
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006209
VERSION     KCXD01006209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17424:4725"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64691.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga ttctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtt tatcttcaga tgaacaacct gaagttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006210             548 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:16908:15282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006210
VERSION     KCXD01006210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 548)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 548)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:16908:15282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    165..546
                     /note="immunoglobulin heavy chain variable region"
     V_region        165..546
     V_segment       165..457
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <450..>515
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64692.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       472..491
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       504..546
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        547..>548
                     /gene="IGHG"
BASE COUNT          118 a          142 c          159 g          129 t
ORIGIN      
        1 acatgggggg acccaaccct gaccctgcag ctctgagaga ggagccttag ccctggattt
       61 caaggcactt ccacctgggg atcagcactg aacacagagg acccaccatg gagttggggc
      121 tgagctgggt tttccttgtt gctattttaa aaggtgtcca gtgtgaggtg caactggtgg
      181 agtctggggg aggcttggtc cagcctggag ggtccctgag actctcctgt gcagcctctg
      241 gattcacctt cagtagttac gacatgacct gggtccgcca ggctccggga aaggggctgg
      301 aatgggtctc atatattagt tacactggta aaaccatata ctactctgac tccgtgaagg
      361 gccgattcac catctccaga gacaacgcca agaactctct gtctctgcaa atgagcagcc
      421 tgagagccga ggacacggcc gtgtattatt gttctagagc ggcttacgaa catgatgacg
      481 gttactatta cgtcggcagg ttttttgact gctggggcca gggagccctg gtcaccgtct
      541 cctcagcc
//
LOCUS       KCXD01006211             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19101:12731
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006211
VERSION     KCXD01006211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19101:12731"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64693.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          116 a          121 c          144 g          129 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga actgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggtggagt ctgggggagg cttggtacag
      181 cctggggcgt ccctgaagct ctcctgtgca gcctctgagt tcaccttcag tgactatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctagaat gggtatcagg tattaacatt
      301 ggcggtgacc catactaccc agactctgtg aagggtcgat tcaccatctc cagagacaac
      361 gccaagaact ccttgtatct tcaaatgaac aacctgagac ctgaggacac tgctgtgtat
      421 tattgtgtga gggggatgga taactaccac ttcagtaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006212             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:24103:12916
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006212
VERSION     KCXD01006212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:24103:12916"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64694.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          142 c          133 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006213             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15274:18772
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006213
VERSION     KCXD01006213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15274:18772"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..496
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64695.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>502
                     /gene="IGHG"
BASE COUNT          113 a          142 c          149 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaaggag cctggggcct cagtgaaggt
      181 ctcctgccag gtttccgaat acaccttcag tgaaatgtcc ttgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgta tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctccccag cc
//
LOCUS       KCXD01006214             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24097:14071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006214
VERSION     KCXD01006214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24097:14071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..470
     V_segment       119..393
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64696.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       402..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT          114 a          133 c          134 g           91 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcag agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg atgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt accggataca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaagga cttgagtgga tgggaagtgt tgatcctgta tatggtgaaa tgaaagaggg
      301 cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac tgagtagcct
      361 gagatctgag gatacggccg tgtattattg tgcagtcggc aatagcggca gctggatctc
      421 ctggtccttc gatgtctggg gccctggcac cccaatcacc atctcctcag cc
//
LOCUS       KCXD01006215             371 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12689:19708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006215
VERSION     KCXD01006215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 371)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 371)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12689:19708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..369
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..369
     V_segment       12..305
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <297..>338
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64697.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       315..320
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       324..369
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        370..>371
                     /gene="IGHG"
BASE COUNT           81 a           88 c          120 g           82 t
ORIGIN      
        1 acatggggtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag cctggggggt
       61 ccctgagact ctcctgtgca gcctctggat tcaccttcag taggcactgg atgaactggg
      121 tccgccaggc tccaggaaag gggctagagt gggtctcaac tattaatagt ggtggggata
      181 acacatatta cgcagactcc gtgaagggcc gattcaccat ctccagagac aactcaaaga
      241 acacgctcct cctgcaaatg aacagcctga gagtggagga cacggccgtg tattactgtg
      301 ttcaagggga aatttttgga gtgggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      361 tctcctcagc c
//
LOCUS       KCXD01006216             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12449:11734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006216
VERSION     KCXD01006216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12449:11734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64698.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       423..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          142 c          146 g          109 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtctcaggt ccagctggtg cagtccgggg ctgagatgga gaagcctggg gcctcagtga
      181 agctctcctg taaggcttct ggatacacct tcagcatcta tgtcatcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gaggcatctt ccctcttgtt ggtacaacaa
      301 actacgcaca gaagttccag ggcagagtca cgattaccgc ggacacgtcc acaagcacag
      361 cctacatgga cctgagcagc ctgggatctg gggacacggc cgtgtattat tgtgcgagag
      421 gttactgtac tggtagtggt tgtaacctta cattcaaccg gctcgatgtc tggggcccgg
      481 gagtcccggt caccgtctcc tcagcc
//
LOCUS       KCXD01006217             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16977:11931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006217
VERSION     KCXD01006217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16977:11931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64699.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          119 a          141 c          135 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctgttgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggg ggtgttgatc ctcaatatgg tgagatgata
      301 gacgcagaga aattccaggg cagagtctcc atgaccgagg acacgtctac agacacagcc
      361 tacatagagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006218             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:24228:12680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006218
VERSION     KCXD01006218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:24228:12680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64700.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          114 c          145 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tcttttaaga ggtgtccagt gtgaggtgca attggtggag tctggaggag gcttgattca
      181 gcctgggggg tccctgaggc tctcctgtgc agcctctgga ttcaccttca gtaattatgg
      241 cttccactgg gtccgccagg ctccagtgaa ggggctggag tgggttgcag ttatgtcgta
      301 tgatgaaaat gtgaaatact acgcagactc tgtaaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgagagggg aatacagtaa ctctattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006219             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20637:6851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006219
VERSION     KCXD01006219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20637:6851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64701.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgctagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 cggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006220             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11997:15053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006220
VERSION     KCXD01006220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11997:15053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64702.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       448..460
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          123 c          152 g          124 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtac aactggtgga atctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccctc agtaactact
      241 ggatgtactg ggttcgccag gcaccaggga aggggctgga gtggatctca gctattaaca
      301 gtgttggtga taccacatac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggcta
      421 tctattactg tgcgagagtt ccgggcctag tggtatttac cggttcgctt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006221             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12280:11460
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006221
VERSION     KCXD01006221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12280:11460"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64703.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          113 c          153 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 tgagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcattaac tatggcattc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgcaca gcctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgtccgg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006222             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17190:14666
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006222
VERSION     KCXD01006222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17190:14666"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64704.1"
                     /translation="CANVLGPWGSWSHYFEYW"
     D_segment       413..422
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          144 c          135 g           99 t
ORIGIN      
        1 acatgggaat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ctcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcctcagag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatcg gtagttactg gtggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg aaatagcggt agtacctact acagcccctc cctcaagagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccaccact ccctgaagct gaactctgtg
      361 accaccgcgg acacggccgt gtatttctgt gcgaacgtct taggcccctg gggcagctgg
      421 tcacactact ttgagtactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006223             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10360:10028
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006223
VERSION     KCXD01006223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10360:10028"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64705.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          141 c          135 g           99 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat ataccttcac cgaactgtcc attcattggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaaa ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggacctg atcagtctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcacc tggctatatt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006224             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5723:16653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006224
VERSION     KCXD01006224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5723:16653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64706.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       447..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          114 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggg ggcttcgttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtatctctg
      241 gcatgcattg ggtccgccag gctccaggga aggggctgga gtgggtggca gttaaatcgt
      301 ttgatggaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gagattggag gacacggccg
      421 tttattactg tgtgagagat gcctacggga gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006225             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22773:15074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006225
VERSION     KCXD01006225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22773:15074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..448
     V_segment       85..378
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64707.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       382..389
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           92 a          130 c          124 g          104 t
ORIGIN      
        1 acatgggggg acctcctgtg caagaacatg aagcacctgt ggttcttcct tctcctggtg
       61 gcagctccca gatgggtcct gtcccaggtg cacctgcagg agtcgggccc aggactggtg
      121 aagtcttcgg agaccctgtc cctcacctgc ggtgtctctg gtgactccat cagcaatagc
      181 tactggaact ggatccgcca gcccccaggg aagggactgg agtggattgg gtatatctct
      241 ggtgcttatg ggagcaccag ctacaatccc tccctcaaga gtcgagtcac catttcaaca
      301 gacacgtcca agaaccagtt ttccctgagg ctgagttctg tgaccgccgc ggacaccgcc
      361 gtgtattatt gtgtgagata tgaggatgaa tccattaact accactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006226             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:24285:12953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006226
VERSION     KCXD01006226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:24285:12953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64708.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       443..450
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          119 c          148 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttcag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg ccgcctctgg attcaccttc agtacttata
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaac taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01006227             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8299:19956
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006227
VERSION     KCXD01006227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8299:19956"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64709.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       445..465
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          112 a          115 c          157 g          126 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgac actctcctgt gtagcctctg gattcacctt cagtagctat
      241 ggcatgggct gggtccgcca ggctccaggg aaggggctgg agtgggtggg aattgtttcg
      301 tttgatggaa ctaagagata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca agaatatcct atatcttcaa atgaacaacc tgaaattcga agacacggcc
      421 gtgtattata gtacgagagt agactgtagt ggtggtgtct gctactttga ccactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006228             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13381:17854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006228
VERSION     KCXD01006228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13381:17854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64710.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       448..453
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          118 c          159 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgaactgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagttggtgg agtctggggg cggcttggca
      181 aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagacac
      241 tggatgaact gggtccgcca gcctccagga aaggggcttg agtgggtctc aactattaat
      301 agtggtgggg ataacacata ttacgcggac tccgtgaagg gccgattcac catctccaga
      361 gacaattcaa agaacacgct cctcctgcaa atgaacagcc tgagagtgga ggacacggcc
      421 gtgtattact gtgttcaagg ggaaattttt ggagtgggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006229             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17991:5773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006229
VERSION     KCXD01006229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17991:5773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64711.1"
                     /translation="CAAGHSGSWNYWYFDFW"
     D_segment       429..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          140 c          144 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctcccctg cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg ggggtgttga tcctgcattt ggtgaaatga
      301 tacacgtaga gaggttccag ggcagagtca ccctgaccga ggacacgtct acagatacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtttttc tgtgcagccg
      421 gacatagtgg cagctggaac tactggtact tcgatttctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01006230             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15156:16847
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006230
VERSION     KCXD01006230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15156:16847"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64712.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           99 a          139 c          142 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca gccacttccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcg tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgtatatggt gaaatggtgt
      301 tccagggcgg ggtcaccatg accgaggaca cgtctacaga cacagcctac ttggagctga
      361 acagcctgag gtctgaagac acggccgtgt attactgtgc gattggccct agcggcatct
      421 ggaacggctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01006231             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23871:12293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006231
VERSION     KCXD01006231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23871:12293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64713.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          140 c          143 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataatata
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag cc
//
LOCUS       KCXD01006232             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:4621:7146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006232
VERSION     KCXD01006232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:4621:7146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..395
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64714.1"
                     /translation="CASLLNPSSDSW"
     D_segment       401..406
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           83 a          134 c          137 g          102 t
ORIGIN      
        1 acatggggga ggtctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gtcttcggag accctgtccc tcacctgcgc tgtttctggt
      181 ggctccatca ggggttactg gtggggctgg atccggcagt ccccagggaa gggtctggag
      241 tggattggct atatcggtgg cagtagtggg agcacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagattt ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt gtattcctgt gcgagtcttc taaacccttc gagtgactcc
      421 tggggccagg gagtcctggt caccgtctcg tcagcc
//
LOCUS       KCXD01006233             419 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17354:5419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006233
VERSION     KCXD01006233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 419)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 419)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17354:5419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..417
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..417
     V_segment       63..355
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>386
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64715.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       362..373
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       374..417
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        418..>419
                     /gene="IGHG"
BASE COUNT           79 a          126 c          123 g           91 t
ORIGIN      
        1 acatggggaa gcacctgtgg ttcttcctcc tcctggtggc agctcccaga tgggtcctgt
       61 cccagctgca attgcaggag tcgggcccag gactggtgaa gccttcggag accctgtctg
      121 tcacctgcgc tgtctctggt ggctctatca gcatttacta ctggaattgg atccgccagg
      181 ccccagggaa gggactggac tggattggac atatctatgg gagcggtggt agcaccaact
      241 acaacccctc cctcaagagt cgagtcaccc tgtcagtaga cacgtccaag aaccagttct
      301 ccctgaacct gaggtctgtg accgccgcgg acacggccgt atattactgt gcgagcggtc
      361 ggcggcagct ggactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006234             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:6567:5680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006234
VERSION     KCXD01006234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:6567:5680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..475
     V_segment       112..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64716.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       414..421
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           98 a          137 c          144 g           98 t
ORIGIN      
        1 atggggaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat caccatggac
       61 ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc ccaggtccag
      121 ctggtgcagt ccggggctga tgtgaagaag cctggggcct cagtgaagct ctcctgcaag
      181 gcttctggat tcgccttcag aatgtatgcc ctcagttggg tgcgacaggc ccctggacaa
      241 gggcttgagt ggctgggagg gatcgtccct cttgttggaa caacaaactc cgcacagaag
      301 ttccaggaca gagtcacgat taccgcggac acgtccacaa gcacagtcta catggagctg
      361 agcagcctga gatctgacga cacggccgtg tattactgtg cgagaggcct gggtagcagc
      421 gcccactttg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006235             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7495:4556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006235
VERSION     KCXD01006235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7495:4556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64717.1"
                     /translation="CARWGTPFDYW"
     D_segment       399..403
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           89 a          135 c          132 g           99 t
ORIGIN      
        1 acatgggggg tcctctgaga gtcacggacc tcctgggcaa gaacatgaag catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcttgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggta
      181 actccatcaa cagtggttat gcctggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtgggttgg gcatatctat gatagtagtg ggaacaccta ctacagcccc tccctcaaga
      301 gtcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgatg ctgaattctg
      361 tgaccgccgc ggacacggcc gtatattact gtgcgagatg ggggaccccc tttgactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006236             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21098:8800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006236
VERSION     KCXD01006236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21098:8800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64718.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          113 c          154 g          120 t
ORIGIN      
        1 acatggggag ggctgggaga ggggcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaac aaagaaattc tacgcagact ctctgaagga ccgcttcatc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaataacct gaaattagag gacacggccg
      421 tatatttctg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggtgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006237             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16075:9868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006237
VERSION     KCXD01006237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16075:9868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64719.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          108 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgaagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtctct gagactctcc tgtgcagctt ccggattcac cttcagtttc tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttaca tcgaatgatg
      301 aaagtaagaa atactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaaatt gaaggacacg gccgtgtact
      421 actgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006238             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8693:20286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006238
VERSION     KCXD01006238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8693:20286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64720.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          133 c          137 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggc tatatatatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtgg acacgtccaa gaaccagtgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtatttttg tgcgagttcg ggtatagaag tggttgcgta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006239             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:9645:16727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006239
VERSION     KCXD01006239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:9645:16727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..448
     V_segment       88..378
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <370..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64721.1"
                     /translation="CVKGETAAAYYGLDSW"
     D_segment       385..390
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..448
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT          103 a          110 c          134 g          103 t
ORIGIN      
        1 acatggggca ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt
       61 gttgctattt taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg
      121 gcaaaacctg ggggatccct gagactctcc tgtacagcct ctggattcac cttcaatact
      181 tattctatgc attgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctgtt
      241 agtagtagtg ggagcacata ctacgcagac tccgtgaggg gccgatgcac catctccaga
      301 gacaactcaa agaacataat ctccctgcaa atgaacagcc tgagaactga ggacacggcc
      361 ctatattact gtgtgaaagg agaaacagct gcagcatact acggtttgga ttcctggggc
      421 caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006240             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16593:12596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006240
VERSION     KCXD01006240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16593:12596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64722.1"
                     /translation="CASGSRRQPDKW"
     D_segment       403..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..452
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           85 a          138 c          139 g           92 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg gctcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atcggtggaa ctagtgggag cacctactac aacccctccc tcaagagccg
      301 agtcaccatt tcaacagaca cgtccaagaa ccaggtctcc ctgaagttga tcactgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagtggaagt cggcggcagc cggataaatg
      421 gggccagggc ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006241             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18821:13220
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006241
VERSION     KCXD01006241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18821:13220"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..489
     V_segment       120..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64723.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       414..423
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          135 c          132 g          106 t
ORIGIN      
        1 acatggggaa aaacaaccac atccctcctc taaagaagcc cctgggagca cagctcatca
       61 ccatggactg gacctggagg ctcctctttg tggtggcagc agctacaggt gtccagtccc
      121 aggtccagct ggtgcagtcc ggggctgagg tgaagaagcc tggggcctca gtgaaggttt
      181 cctgcaaggc ttctggattc accttcgaca actatggtat caactgggtg cgacaggccc
      241 ctggacaggg gcttgagtgg atgggagtaa ccatccccct tgttggtata atcaactaca
      301 gagacaacgt ccaggacaga gtcaccattt ccgcggacac gtccacaaac acagcctaca
      361 tggaaataaa cagcctgaga tctgacgaca cggccatcta ttactgtgcg agagaatatt
      421 gtacttctac tgattgcgcc ggattttttg acttctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006242             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18014:9176
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006242
VERSION     KCXD01006242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18014:9176"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64724.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          121 a          142 c          133 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctgttgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg gagtgttgat cctcaatatg gtgagatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga cgacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca tcc
//
LOCUS       KCXD01006243             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:17389:6177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006243
VERSION     KCXD01006243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:17389:6177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64725.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       439..444
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          110 a          112 c          154 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcggaacct atggcatgca
      241 ctgggtccgc caggctccag ggatgggcct ggagtgggtg acggttatat cgaatgatgg
      301 aagtaagaaa tactacgcag actctgtgaa ggaccgattc agcatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cgtgaaattg gaggacacgg ccgtttatta
      421 ctgtgtgaga gatgcgtttg gtagcgggct tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006244             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9126:5816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006244
VERSION     KCXD01006244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9126:5816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..450
     V_segment       87..380
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64726.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       384..391
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           91 a          131 c          126 g          104 t
ORIGIN      
        1 acatggggat ggacctcctg tgcaagaaca tgaagcacct gtggttcttc cttctcctgg
       61 tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc ccaggacagg
      121 tgaggccttc ggagaccctg tccctcacct gcgctgtctc tggtgactcc atcagcagta
      181 gctactggaa ttggatccgc cagcccccag ggaagggact ggagtggatt gggtatatct
      241 ctggtgctta tgggagcacc agctacaacc cctccctcaa gagtcgagtc accatttcaa
      301 cagacatgtc caagaaccag ttttccctga ggctgagttc tgtgaccgcc gcggacaccg
      361 ccgtgtatta ctgtgtgaga tatgaggatg aatccattaa ctaccacttt gacttctggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006245             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11105:18009
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006245
VERSION     KCXD01006245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11105:18009"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64727.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       427..436
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          132 c          147 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 ccccaggaaa agggcttgag tggatgggaa gtgttgatcc tgtatatggt gaaataattg
      301 tcgcagagaa tttccaggac agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg gaatctgagg acacggccgt gtattactgt gcgaaaggga
      421 ggagtggtgg tgtctggccg agctccttcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006246             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:9664:9393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006246
VERSION     KCXD01006246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:9664:9393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..505
     V_segment       135..428
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64728.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       451..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>509
                     /gene="IGHG"
BASE COUNT          103 a          128 c          159 g          119 t
ORIGIN      
        1 acatgggggg agacaggagc cttagccctg gattccaaga acttccactt tgggatcagc
       61 tctgaacaca gaggaccatg gagttggggc tgagctgggt tttccttgtt gctattttaa
      121 aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt tggtgattat ggcatgcact
      241 gggtccgcca ggctccggga aagggactgg agtgggtctc atccattagg aacactggta
      301 aaatcgtata ctacgctgac tccgtgaagg gccgattcac catttccaga gacaacgcca
      361 agaactcgct gtctctgcga atgagcagcc tgagagccga ggacacggcc gtgtactact
      421 gtactagaat tggcgtcgga tctctggcaa cggctggtga ctactttgac cactggggcc
      481 agggagtcct ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01006247             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21946:12315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006247
VERSION     KCXD01006247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21946:12315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64729.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          109 c          156 g          120 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggcggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgtagcctc tggatttact ttcagtagta gtggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg gctgttgaat cgcatgatgg
      301 aaataagaaa tactatgcag actccgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg gtatatcttc aaatgaacag cctgaaattg gtggatacgg ccatgtatta
      421 ctgtgtgaga gatgcctacg ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006248             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:27777:9061
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006248
VERSION     KCXD01006248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:27777:9061"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..502
     V_segment       139..432
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64730.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       438..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          119 c          158 g          118 t
ORIGIN      
        1 acatggggga gagaggagcc ttagccctgg atttcaaggc acttccacct ggggatcagc
       61 actgaacaca gaggacccac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtgtga ggtgcagttg gtggagtctg ggggaggctt ggtccagcct
      181 ggagggtctc tgagactctc ctgtgtagcc tctggattca gcttcagaag ttacgaaatg
      241 agttgggtcc gccaggctcc gggaaagggg ctggagtggg tctcatatat tagtcacact
      301 ggtgaaacca tataccacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaatt cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tactgtacta ggaaccggaa tactgtaatg attgggtggt tcgatgtctg gggcccggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006249             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17196:18090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006249
VERSION     KCXD01006249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17196:18090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..363
     V_segment       1..287
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64731.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       295..302
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..363
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           75 a          100 c          105 g           85 t
ORIGIN      
        1 tgcaggagtc gggcccagga ctggtgaagc cttcagagac cctgtccctc atatgcgctg
       61 tctctggagg ctctatcagc ggtggttatg actggagctg gatccgccag cccccaggga
      121 ggggactgga gtggattggg tatatctatg gtagtcgtgg gggcgccacc tacaacccgt
      181 ccctcaagaa tcgagtcacc atctcaaaag acacgtccaa gaaccagttg tccctgaagc
      241 tgaaccctgt gaccgccgcg gacacggccg tatattattg tgcgagacag tgttgttact
      301 atgatgactt tttagactac tttgacttct ggggccaggg agtcctggtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01006250             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13178:3509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006250
VERSION     KCXD01006250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13178:3509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..523
     V_segment       142..434
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64732.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       449..468
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       481..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          114 a          131 c          154 g          126 t
ORIGIN      
        1 acatggggtc tgagagagga gccttagccc tggatttcaa ggcacttcca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggagg cttggtccag
      181 cctggagggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttacgac
      241 atgacctggg tccgccaggc tccgggaaag gggctggaat gggtctcata tattagttac
      301 actggtaaaa ccatatacta ctctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgccaaga actctctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtg
      421 tattattgtt ctagagcggc ttacgaacat gatgacggtt actattacgt cggcaggttt
      481 tttgactgct ggggccaggg agcccaggtc accgtctcct cagcc
//
LOCUS       KCXD01006251             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17168:18168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006251
VERSION     KCXD01006251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17168:18168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..500
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64733.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       422..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          117 a          140 c          146 g          101 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaacc ctggtgcctc agtgaagctc
      181 tcctgcaagg ggtctggact caccctcagc accgaggcca tcagttgggt gcgacaggcc
      241 cctggacaag gacctgactg gatgggaggg atcatccctc tcgtgggtgc aacaaactac
      301 gcacagaagt tccagggcag agtcaagttt atcgcggaca cgtccataaa cacagcctac
      361 atggaactga gcggcctgag atctgaggac acggccgtgt attattgtgc gaaatccgtg
      421 aattacgagg aagataatgg ttactattta ccgacggggt ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01006252             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15768:8110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006252
VERSION     KCXD01006252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15768:8110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64734.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          135 c          132 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag cccccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagt agtagctact ggaactggat ccgccagccc ccggggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgagtcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006253             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21914:6024
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006253
VERSION     KCXD01006253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21914:6024"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64735.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       448..452
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          128 c          152 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccatt gtgaggtgca gctggtggaa tctgggggcg gcttggcaaa
      181 gcctgggggg tccctaagac tctcctgtgc agcatccgga ttcaccttca gtgaccactg
      241 catgcactgg gtccgccagg cttcagggaa ggggctggag tgggtctcag gtattactta
      301 tactggtgtt accacttggg acgcagactc cgtgaggggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcacat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gtgacaggaa ggcgacacgt ggaccttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006254             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23335:15569
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006254
VERSION     KCXD01006254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23335:15569"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64736.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       408..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          106 a          143 c          135 g           93 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgag gtgatgcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccttcacc gaattgtcca tgcactgggt gcgacaggcc
      241 ccaggaagag gccttgagtg ggtgggaagt gttgatcctg catatggtga aatgacgttc
      301 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagc
      361 agcctgagat ctgaggacac ggccgtatat tactgtgcga tcggccctag cggcagttgg
      421 aacgcctggt ccttcgatat ctggggccat ggcaccccaa tcgccatctc ctcagcc
//
LOCUS       KCXD01006255             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16089:17715
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006255
VERSION     KCXD01006255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16089:17715"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64737.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       430..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          114 a          142 c          143 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggctggga ggtgttgatc ttgcatatga tgaaataata
      301 catgcagaga agttccaggg cagagtcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggaac tgagcagcct gagatctgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgct cactgaatac ctcgagttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01006256             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12363:10642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006256
VERSION     KCXD01006256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12363:10642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..482
     V_segment       104..411
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64738.1"
                     /translation="CASADSGYPPYFFDFW"
     D_segment       418..427
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           84 a          142 c          142 g          116 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtct gtcacctgcg atgtctctgg
      181 tggctctatc accagcacca actggagctg gatccgccgg gccccaggga agggactgga
      241 gtggattggg tgtatctttg gtggtggtat ctttggtggt ggtagtaaca cccactacag
      301 tccctccctc aagagtcgag tcaccctgtc agtagacgcg tccaagaacc aactctccct
      361 gcagctgacg tctgtgaccg ccgcggacac ggccgtgtat ttctgtgcga gcgctgatag
      421 tggttatcct ccctacttct ttgacttctg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01006257             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18377:12232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006257
VERSION     KCXD01006257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18377:12232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64739.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          135 c          129 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga caggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaattggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca tgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006258             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11707:9609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006258
VERSION     KCXD01006258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11707:9609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64740.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       441..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          108 c          154 g          117 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgaact gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagttg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagct tctggattca ccttcagtag ttatggcatg
      241 cactgggtcc gcctggctcc agggaagggg ctggagtggg tggcagttac atcgtctgat
      301 gaaagtaaga aatactacgg agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tactatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtac
      421 tactgtggga gagatgataa tggggtgatt atcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006259             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22944:13506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006259
VERSION     KCXD01006259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22944:13506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64741.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       454..461
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          102 a          132 c          158 g          125 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgctgcttt
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct gggggggcct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attgtggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttagtaagac
      301 tggtgaaacc gaatactaca ctgactccgt gaagggccga ttcaccatct ccagaaacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgcact agaatttgtt gtccccgtga ttttagcagc gactgtcact ggttcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006260             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18879:8061
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006260
VERSION     KCXD01006260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18879:8061"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64742.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          143 c          136 g           96 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaaa ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagtctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcacc tggctatatt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006261             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14850:9449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006261
VERSION     KCXD01006261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14850:9449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64743.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          113 a          142 c          128 g           92 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaggct tccggataca ccttaaccga ccactaccta cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtat tcttcctgag tatggtaaag ttgactacac
      301 acagaagttc caagacagag tcaccatcac cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgactact ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006262             297 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11600:20440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006262
VERSION     KCXD01006262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 297)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 297)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11600:20440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..295
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..295
     V_segment       7..225
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <217..>264
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64744.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       239..244
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..295
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        296..>297
                     /gene="IGHG"
BASE COUNT           65 a           76 c           86 g           70 t
ORIGIN      
        1 acatggggat tcagcttcag tttctactac atgagctggg tccgccagcc tccagggaag
       61 ggtctggagt ggatctcagg tattaacgct ggtggggatg gcacatactc tgcagactcc
      121 gtgaagggca gattcaccat ctccagagag aacgccaaga acacactgca tcttcaaatg
      181 gacagcctga gaactgagga cacggctgtc tatttctgtg tgagagatcg acgtgttcag
      241 tcgttatcct ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006263             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24181:16987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006263
VERSION     KCXD01006263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24181:16987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64745.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       448..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          112 a          121 c          158 g          123 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg ttcacctggt gcagtctggg ggcggcttga caaagcctgg
      181 ggggtccctg agactctcct gtgcggcctc cggattcacc ttcagtaact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgaatca gtcatgatgg
      301 tgatagcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagaatgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gaggacacag ccgtatatta
      421 ctgtgcgaga gagcgttttg ggggaattgg ggtgattatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01006264             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13647:8010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006264
VERSION     KCXD01006264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13647:8010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64746.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       414..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          146 c          137 g           89 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccctc accgaagtgt ccactcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctaa gatctgagga cacggccgtg tattactgtg cgattggccc taccggcagg
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01006265             388 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:14459:2751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006265
VERSION     KCXD01006265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 388)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 388)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:14459:2751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..386
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..386
     V_segment       20..311
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>355
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64747.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       325..331
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       335..386
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        387..>388
                     /gene="IGHG"
BASE COUNT           94 a          101 c          113 g           80 t
ORIGIN      
        1 acatgggggc gcccactctg aggtccagct ggtgcagtct ggggctgagg tgaagaagcc
       61 tggggcctca gtgaaggtct cctgcaaggt ttccggatac atcttaaccg aattatccat
      121 gcactgggtg cgacaggccc ctggagaagg gcttgagtgg atgggaagtg ttgatcctca
      181 atatggtgaa atgatagacg cagagaaatt ccagggcaga gtcaccatga ccgaggacac
      241 gtctacagac acagcctaca tggaactgag cagtctgaga tctgaggaca cggccgtata
      301 ttactgtgcg acatcatcca gcggcacctg gctatactgg tacttcgata tctggggccc
      361 tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006266             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12267:4389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006266
VERSION     KCXD01006266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12267:4389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..496
     V_segment       133..426
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64748.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..445
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          101 a          124 c          152 g          121 t
ORIGIN      
        1 acatggggga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg atcagcacta
       61 aacacagaac aaaccatgga gtttgtgctg agctgggttt tccttgttgc tcttttgaaa
      121 ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa gcctgggggg
      181 tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta catgagctgg
      241 gtccgccagc ctccagggaa gggtctggag tggatctcag gtattaacgc tggtggggat
      301 ggcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag
      361 aacacactgc atcttcaaat ggacagcctg agaactgagg acacggctgt ctatttctgt
      421 gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006267             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13952:10025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006267
VERSION     KCXD01006267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13952:10025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64749.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       436..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          110 a          115 c          149 g          116 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaagtgc agctggtgga gtctggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactctt gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga atgggtggcg gttatatcca atgatggaag
      301 taagaaatac tacgcagact ctgtgaagga ccgattcagc atttccaggg acaaccccaa
      361 gaacatgcta tatcttcaaa tgaacaacct gaaattggat gacacggccg tctattactg
      421 tgcgacagat gcgtttggta gcgggattga ctactggggc cggggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01006268             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18439:13051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006268
VERSION     KCXD01006268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18439:13051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64750.1"
                     /translation="CVRYEDESINYHFDNW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           99 a          139 c          125 g          107 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagttccca gatgggtcct gtcccaggtg cagctccagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc actgtctctg
      181 gtgactccat caccagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccactt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga caactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006269             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22628:19082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006269
VERSION     KCXD01006269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22628:19082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64751.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       235..241
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           70 a           68 c           85 g           66 t
ORIGIN      
        1 acatggggga ttcaccttca gtagctttgg catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggcag ttatatcgtc tgctggaagt aagaaatact acgcagactc
      121 tttgaaagac cgattcacca tatccagaga cgactccagg aacatgctat atcttcaact
      181 gaacaacctg aaattggagg acacggccgt gtattactgt gcgagagatg tgtatggctg
      241 ggggcttgac tactggggcc agggagtcct agtcaccgtc tcctcagcc
//
LOCUS       KCXD01006270             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:3092:11599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006270
VERSION     KCXD01006270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:3092:11599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64752.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtt tatcttcaga tgaacaacct gaagttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006271             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:15399:7675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006271
VERSION     KCXD01006271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:15399:7675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64753.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       423..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          119 a          139 c          140 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 gtctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctggga cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccgttcatt gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtattgat cctctatatg gtgaaatgat
      301 acacacagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagatacagc
      361 ctacatggag ctgaggagcc tgagatctga cgacacggcc gtgtattact gtgcgaggtc
      421 ggatagcggc agttggaacg gctggtacct cgatctctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006272             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6361:15098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006272
VERSION     KCXD01006272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6361:15098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64754.1"
                     /translation="CARGGDIEYCTGSGCGELDSW"
     D_segment       426..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          120 a          139 c          139 g          103 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ctctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcaac tggtgcagtc tgggggtgag attaagcagc ctggggcctc agtgaagctc
      181 tcctgtcagg cttctggata ttccctcact cactacttca tgcactgggt gagacaggcc
      241 cctggacagg gccttgagtg gataggactg atcacccctc acaatgatca taaagtctac
      301 gcacagaact tccagggcag agtcaccata actacggaca cgtccacgag cacagtgtcc
      361 atggagctga gcagcctgag atccgaagac acagccgtat actactgtgc gagagggggg
      421 gacatagaat attgtactgg tagtggttgt ggggagcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006273             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7317:3592
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006273
VERSION     KCXD01006273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7317:3592"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..511
     V_segment       142..438
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64755.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       449..463
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          108 a          123 c          154 g          128 t
ORIGIN      
        1 acatgggggt ctaggagagg agcccagccc tgggattccc aggtgttttc atttgtgatc
       61 agcactgaac acagaagact catcatggag tttggcctga gctgggtttt ccttgttgct
      121 atattaaaag gtgtccaggg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tgactactgg
      241 atgtactggg ttcgccagac acctgagcgg ggcctggagt ggatctcagc tattgatagt
      301 gctgttacta gtaccacata ctatgcagac tccgtgaagg gcagattcac catctccaga
      361 gagaacgcca aaaacacact gtatcttcag atggacagcc tgagaactga ggacacggct
      421 gtctattact gtgcgagagt tccgggccta gtggtattta ctggttcgct tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006274             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:24323:2801
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006274
VERSION     KCXD01006274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:24323:2801"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64756.1"
                     /translation="CARVSGITESSVEYFEFW"
     D_segment       438..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..507
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          119 a          120 c          150 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagc tatggcatgc
      241 actgggtccg ccagtttcca ggggaggggc tggaatgggt ggcacttata tcgtatgatg
      301 gaactaagaa atactacgga gactctatga aggaccgatt caccatctcc agagacaatt
      361 ccaacaacat gctatatctt caaatgaaca acctcaaagt ggaggacacg gccgtctatt
      421 actgtgcgag agtaagcggt ataactgaaa gttccgttga atacttcgag ttctggggcc
      481 agggcgccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006275             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17548:7852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006275
VERSION     KCXD01006275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17548:7852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..428
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64757.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       446..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          113 a          116 c          149 g          129 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgttgct
      121 atgttaaaag gtgtccagtg tgtggagcag ctggtggaat ctgggggagg cttacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctttgacatg
      241 cactgggttc gccaggctcc agggaagggt ctggactggg tatcaggtat taacattggc
      301 ggtgacacat actacccaga ctctgtgaag ggtcgattca ctatgtccag agacaatgcc
      361 aagaactccg tgtatcttca aatgaacagc ctgagagttg aggacactgc tgtgtatttt
      421 tgtgcaaggg ggatagataa ctaccactat agtgatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006276             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26007:7866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006276
VERSION     KCXD01006276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26007:7866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64758.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          123 c          146 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgcagggtcg attcaccatc tccagagaca
      361 acgccaagaa ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006277             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9769:11307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006277
VERSION     KCXD01006277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9769:11307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64759.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       419..425
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          140 c          144 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctcca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc accgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctga tggagtgata
      301 tacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgcgagaggt
      421 gtgacagcag acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006278             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21096:8806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006278
VERSION     KCXD01006278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21096:8806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64760.1"
                     /translation="CATGRMGSSGWSNLFTGLESW"
     D_segment       428..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          144 c          147 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aggtgaagca gcctggggcc tcagtgaagg
      181 tctcctgtaa ggtttccgga tacaccgtca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa aggccttgag tggatgggag ttgttgatcc tgtcaatggt gaagaaatac
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggactt gaccagtctc agatctgagg acacggccat ctattactgt gcgacaggga
      421 ggatgggtag cagcggctgg tccaacctct tcactggttt ggaatcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006279             356 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17591:16882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006279
VERSION     KCXD01006279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 356)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 356)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17591:16882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..354
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..354
     V_segment       4..283
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <276..>323
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64761.1"
                     /translation="CVKGDTAAVYYGLDFW"
     D_segment       287..296
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       303..354
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        355..>356
                     /gene="IGHG"
BASE COUNT           73 a           96 c          107 g           80 t
ORIGIN      
        1 acatggggga gtctgggggc ggcttggcag agcctggggg atccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agtacctatg ctgttcactg ggtccgccag gctccagaaa
      121 aggggctgga gtgggtctca gctgttagta ccggtggtac cacatactac tcagactccg
      181 tgaagggccg attcaccatc tccagagaca actcaaagaa cacgttctcc cttcaaatga
      241 gcagcctgag agctgaggac acggccgtgt attactgtgt gaagggggat acagctgcag
      301 tctactacgg tttggatttc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006280             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22553:12643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006280
VERSION     KCXD01006280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22553:12643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..475
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64762.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       416..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>481
                     /gene="IGHG"
BASE COUNT           85 a          143 c          139 g          114 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaac aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggttctgtcc cagctgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agtaccaact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtgt atctttggtg gtggtatctt tggtggtgga agtaacacct actacagccc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagacccagc tctccctgaa
      361 gttgacgtct gtgaccgccg cggacacggc cgtatatttc tgtgcgagcg ctgacagtgg
      421 ttatcctccc tacttctttg acatctgggg ccagggagtc ctggtcaccg tctccccagc
      481 c
//
LOCUS       KCXD01006281             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17592:4271
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006281
VERSION     KCXD01006281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17592:4271"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64763.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       419..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          147 c          136 g           94 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcaa caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccattcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggcgttgat cctgcatatg gtgagtttac
      301 acccggagag aagctccagg gcagagtcac catgaccgaa gacacgtcta tagacacagc
      361 ctacatggag ctgagcagcc tgaattctga cgacacggcc gtctattact gtgctgccgg
      421 gtatagcggc agctggaacc actggtactt cgatctctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006282             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:5380:18683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006282
VERSION     KCXD01006282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:5380:18683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64764.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          104 a          127 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc
      301 tggtggggat accacctact atgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaact ggacagcctg agagctgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtgt cctcagcc
//
LOCUS       KCXD01006283             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17023:19913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006283
VERSION     KCXD01006283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17023:19913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64765.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          117 c          147 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt ttccttgtta
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01006284             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10179:5888
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006284
VERSION     KCXD01006284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10179:5888"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64766.1"
                     /translation="CVTGPSGTWNAWYLEIW"
     D_segment       420..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          113 a          143 c          136 g           91 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaactggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 agggtctcct gcaaggtttc cggatacacc ttcaccgaat tatccataca ctgggtgcgg
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctctata tggtgaaatg
      301 aagttccagg gcagagtcac catgaccgag gacacgtctg cagacacagc ctacatggaa
      361 ctgagtagcc tgacatctgg ggacacggcc gtgtattact gtgtgactgg ccctagcggc
      421 acctggaacg cctggtacct cgaaatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01006285             303 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9189:5678
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006285
VERSION     KCXD01006285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 303)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 303)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9189:5678"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..301
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..301
     V_segment       8..228
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <220..>270
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64767.1"
                     /translation="CARDSSWYNWNQDFDYW"
     D_segment       239..252
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       257..301
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        302..>303
                     /gene="IGHG"
BASE COUNT           70 a           85 c           86 g           62 t
ORIGIN      
        1 acatgggctg gtggctccat caccggtaac tactggagct ggatccgcca gcccccaggg
       61 aagggactgg agtggattgg acgtagcact gatagtggtg ggagtactga ctacaacccc
      121 tccctcaaga gtcgagtcac catttcaaca gacacgtcca agaaccagtt ctccctgaag
      181 ctgagctctg tgaccgccgc ggacacggcc gtgtattact gtgcgagaga tagtagttgg
      241 tataactgga accaagactt tgactactgg ggccagggac tcctggtcac cgtctcctca
      301 gcc
//
LOCUS       KCXD01006286             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4078:12674
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006286
VERSION     KCXD01006286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4078:12674"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64768.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       443..454
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          110 c          152 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cttctggatt caccttcagt agttatggca
      241 tgcactgggt ccgcctggct ccagggaagg ggctggagtg ggtggcagtt acatcgtctg
      301 atgaaagtaa gaaatactac ggagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catactatat cttcaaatga acaacctgaa attgaaggac acggccgtgt
      421 actactgtgg gagagatgat aatggggtga ttatcgactt ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006287             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24174:15828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006287
VERSION     KCXD01006287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24174:15828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64769.1"
                     /translation="CVRDGYGSGLDAW"
     D_segment       441..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          106 c          160 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcggg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagcacg tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata acgaatgatg
      301 gaagtaagaa ttactacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaatat ggtatatatt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgggtac ggtagtggtt tggatgcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006288             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15088:12576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006288
VERSION     KCXD01006288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15088:12576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64770.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          113 c          157 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatatctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctggg gtgggtgtca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa aaacatggtt tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006289             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:6423:4545
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006289
VERSION     KCXD01006289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:6423:4545"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64771.1"
                     /translation="CATGRIGSSAWSSLFTGLDSW"
     D_segment       431..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          116 a          148 c          147 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg gaaagggcct gagtggatgg gagttgttga tcctgtcaat ggtgaagaaa
      301 tacacgcaga gaagttccag ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga cttgaccagt ctcagatctg aggacacggc catctattac tgtgcgacag
      421 ggagaatcgg tagcagcgcc tggtccagcc tcttcaccgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006290             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17655:15218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006290
VERSION     KCXD01006290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17655:15218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..336
     V_segment       1..266
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64772.1"
                     /translation="CARGRYNWKGVLVDFW"
     D_segment       271..283
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..336
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           69 a          100 c           94 g           75 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt gactccgtca
       61 gcaataacta ctggacttgg atccgccagc ccccagggaa ggggctggaa tggattggcc
      121 gtatctatgg tcgtattggg aacaccgact acaacccctc cctcaacagt cgagtcgcca
      181 tttcaacaga cacgtccaag aaccagttct ccctgaagct cagctctgtg acggccgcgg
      241 acacggccgt ttattactgt gcgagaggcc ggtataactg gaaaggtgtc ttagtggatt
      301 tctggggcca agggctcagg gtcgccgtct cttcagcc
//
LOCUS       KCXD01006291             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:8758:2559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006291
VERSION     KCXD01006291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:8758:2559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64773.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       441..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          114 c          152 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcttt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatt tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggcagttaaa tcgtttgatg
      301 gaactaagat atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agacgcctac gggagcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006292             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6294:10802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006292
VERSION     KCXD01006292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6294:10802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64774.1"
                     /translation="CARDDLGSGFDYW"
     D_segment       444..450
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          111 c          150 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctgttt
      121 taagaggtgt ccagtgcgag gtgcagctgg tggagtctgg aggagacttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtctgatg
      301 gaagtaagac atactacgca aactctgtga aggaccgatt caccatatta agagacaatt
      361 ccaagaatat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agacgatttg ggaagtggct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006293             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19428:1851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006293
VERSION     KCXD01006293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19428:1851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64775.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          137 c          141 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gaatatggtg aactgacgtt
      301 ccaggggaga gtcaccatga ccgaggacac gtctacagac acggcctaca tggagctgag
      361 tagcctgaga tctgaggaca cgggcgtgta ttactgtgcg attggcccta gcggcaggtg
      421 gaaccactgg tccttcgaga tctggggacc tgggacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006294             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13090:6240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006294
VERSION     KCXD01006294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13090:6240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..396
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64776.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       405..411
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT          102 a          108 c          137 g          112 t
ORIGIN      
        1 acatggggcc attcggtgat cagcacagaa cacagaggac tcaccatgaa gtttgggctg
       61 agctgggttt tccttgttgc tattttaaga ggtgtccagt gtgaggtcca cctggtggaa
      121 tctggaggag gcttggttca gcctgggggg tccctgagac tctcctgtgc agcctctgga
      181 ttcaccttca gtagctttgg catgcactgg gtccgccagg ctccagggaa ggggctggag
      241 tgggtggcag ttatatcgtc tgatgaaagt aagaaatact acgccgactc tttgaaagac
      301 cgattcacca tatccagaga cgactccagg aacatgctat atcttcaact gaacaacctg
      361 aaattggacg acacggccgt gtattactgt gcgagagatg tgtatggctg ggggcttgac
      421 tactggggcc agggagtcct agtcaccgtc tcctcagcc
//
LOCUS       KCXD01006295             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9361:11571
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006295
VERSION     KCXD01006295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9361:11571"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..500
     V_segment       119..411
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64777.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       421..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          138 c          145 g          105 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggc tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccagttg gtgcagtccg gggctgaggt gaagaggcct ggggcctcag tgaagctctc
      181 ctgcaaggct cctggataca tcttcagtat atctgccatc agttgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagggat catccctctt gttggtgtaa caaccaacgc
      301 acagaagttc caggacagag tcacgattac cgcggacacg tccacaagca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat ttctgtgcga gtggcggctt
      421 cgaggatgat aacggtcact attatacgac actaacattt cacgattggg gccagggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006296             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:16249:16981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006296
VERSION     KCXD01006296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:16249:16981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64778.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       434..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..507
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          111 a          119 c          163 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc caggcctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg gtctgacctg ggttttcctt gttggtcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagccttg gctcagcctg
      181 gggggtccct gagactctcc tgtgcagcgt ctgggttcac cttcagtagc tatgccatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagccata tcgtttgatg
      301 gaagtaagaa gaactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtact
      421 actgttcgag ggagtggata cagtgggcgc agttagtgag cggtttggat tcctggggcc
      481 aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006297             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14249:9887
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006297
VERSION     KCXD01006297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14249:9887"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64779.1"
                     /translation="CAREYCTTADCAGFFDSW"
     D_segment       408..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          106 a          127 c          141 g          111 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agctggtgca gtccggggct gagttgaaga agcctggggc ctcagtgaag gtttcctgca
      181 aggcttctgg atttaccttc gacaactatg gaatcaactg ggtgcggcag gcccctggac
      241 aagggcttga gtggatggga gtggtcatcc cccttcttgg tattattaat tatgcagaga
      301 acttccaggg cagagtaacg attaacgcgg acacgtccat aagcacagcc ttcatggagt
      361 tcaggagcct gagatctgac gacacggcca tttatttctg tgcgagagaa tactgtacaa
      421 ctgcggattg cgccgggttc tttgactcct ggggccaggg agtcatggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01006298             298 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7300:17108
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006298
VERSION     KCXD01006298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7300:17108"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..296
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..296
     V_segment       10..235
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <227..>265
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64780.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       244..250
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       257..296
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        297..>298
                     /gene="IGHG"
BASE COUNT           77 a           66 c           87 g           68 t
ORIGIN      
        1 acatggggta gcctctggat tcaccttcag gagttatggc atgcactggg tccgccaggc
       61 tccagggaag gggctggagt gggtggcagt tatatcgtat gatgtaagta agaaatatta
      121 cgcagacgct gtgaaggacc gattcaccat ctccagagac aattccaaga acacgctata
      181 tcttcaaatg aacaacctga aattggagga cacggccgtg tattactgtg ggagagatga
      241 taatggggtg cttatcgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006299             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14478:12807
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006299
VERSION     KCXD01006299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14478:12807"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64781.1"
                     /translation="CARICNGIYCGRYGLDSW"
     D_segment       408..416
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          137 c          137 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgga gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctccatca gtactagcaa ctattggagc tggatccgcc agtccccagg caaggggctg
      241 gaatggattg ggggcaccta tggtaatggt gggagtaccg aatacaaccc ctccttcaag
      301 agtcgaatca gtgtttcaaa agacacgtcc aagaaccagt tctccctgaa gctgaactct
      361 gtgaccgccg cggacaccgc cgtctattac tgtgcgagaa tctgtaatgg tatttattgc
      421 gggcgctacg gtttggattc ctggggccaa ggggtcgccg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006300             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20940:6083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006300
VERSION     KCXD01006300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20940:6083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..477
     V_segment       108..401
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64782.1"
                     /translation="CVRESYSGNYYFNRFDVW"
     D_segment       408..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           99 a          135 c          134 g          111 t
ORIGIN      
        1 acatggggaa aaaatgttct ctgagagtca cggacatcct gtgcaagaac atgaagcacc
       61 tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcccag ctgcagctgc
      121 aggagtcggg cccaggactg gtgaagcctt tggagaccct gtccctcacc tgcgctgtct
      181 ctggtggctc cagtagcaat aattactgga gctggatccg ccagtcccca gggaagggac
      241 tggagtggat tggacatatc tctggtagtg gtgggaggac cgactacaac ccctccctcc
      301 agagtcgagt caccatttca actgacacgt ccaagagcca gttctccctg aagttgagct
      361 ctgtgaccgc cgcggacacg gccgtctatt actgtgtaag agagtcatat agtggtaatt
      421 attacttcaa ccggttcgat gtctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006301             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:17513:7683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006301
VERSION     KCXD01006301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:17513:7683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64783.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          105 a          118 c          162 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctcc ggtattaata
      301 gtggtgggga cactacatac tacgcagact ccgtgaaggg ccgattcacc atgtccagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggatttctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006302             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5571:13944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006302
VERSION     KCXD01006302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5571:13944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64784.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       435..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          142 c          141 g           99 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccaac tggtgcagtc tggggctgaa atgaagaagc ctggggcctc agttagggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gtcgatcctg cacaaggtga aataatacac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagccttc
      361 atggagttga gcagcctgag atctgaggac acggccgtgt atttctgtgc gaaagggggg
      421 ttcggaacca gcgtctggtc caacctcttc tacggtttgg attcctgggg ccaaggggtc
      481 ttcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006303             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13261:9861
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006303
VERSION     KCXD01006303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13261:9861"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64785.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       267..272
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           76 a           74 c           93 g           77 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc agtaactatg
       61 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      121 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      241 tgtattattg tgtgagagat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      301 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01006304             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20102:9986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006304
VERSION     KCXD01006304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20102:9986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..494
     V_segment       118..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64786.1"
                     /translation="CARVRYYGDDYGHSPGRFDVW"
     D_segment       425..436
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          106 a          142 c          147 g          101 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggagactcc tctttgtggt ggcagcagct acaggtgccc agtccccggt
      121 ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga agctctcctg
      181 caaggcatct ggatacacct tcagcatcta tgccatcagt tgggtgcgac aggcccctgg
      241 acaagggctt gagtggatgg gagggatcgt ccctcttgtt gatatggcaa actacgcaga
      301 gaagttccag ggcagagtca ccattaccgc ggacacgtcc acaagtacag cctacatgga
      361 actgagcggc ctgagatctg aggacacggc cgtctattac tgtgcgagag ttcgctatta
      421 cggcgatgat tacggtcact ccccggggag gttcgatgtc tggggcccgg gagtcctgat
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006305             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17426:13280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006305
VERSION     KCXD01006305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17426:13280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64787.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          136 c          127 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactgggt ccgccagccc ccagggaagg gactggaatg
      241 gattgggtat atctctggtg cttatgggac caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtcgaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtat attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006306             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:22941:7007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006306
VERSION     KCXD01006306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:22941:7007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64788.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       448..452
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          150 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gaactgggtt ttccttgtta
      121 ctattttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg caggctctgg attcaccttc agtatttttg
      241 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaaa taaaaaatac tcctcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccga ggccaatgta tatcttcaaa tgaataacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcgtatggct ccggcttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006307             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10904:9102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006307
VERSION     KCXD01006307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10904:9102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64789.1"
                     /translation="CARGRSGGVWPNSFDYW"
     D_segment       426..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          131 c          145 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgatttatcc atgcactggg tgcgacaggc
      241 cccaggaaaa gggcttgagt ggatgggaag tgttgatcct gtatatggtg aaataattgt
      301 cgcagagaat ttccaggaca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagcctgg aatctgagga cacggccgtg tattactgtg cgagagggag
      421 gagtggtggt gtctggccga actcctttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01006308             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6872:19079
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006308
VERSION     KCXD01006308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6872:19079"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64790.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       398..412
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          136 c          133 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggcgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat attagtatta gtgggaggac cgactacaac ccctccctca agagtcgagt
      301 caccatttca acagacacgt ccaagaacca gttctccctg aagttgacct ctgtgaccgt
      361 cgcggacacg gccgtgtatt actgtgcgag atatccatat agtgggagct acttcaggta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006309             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:16823:13675
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006309
VERSION     KCXD01006309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:16823:13675"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64791.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       411..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          108 a          145 c          136 g           88 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgag gtgaagcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata caccctcacc gaagtgtcca ctcactgggt gcgacaggcc
      241 cccggaaaag ggcttgagtg ggtgggaagt gttgatcctg catatggtga aatgaagttc
      301 cagggcagag tcaccatgac cgaggacacg tccacagaca cagcctacat ggaactgagc
      361 agcctaagat ctgaggacac ggccgtgtat tactgtgcga ttggccctac cggcaggtgg
      421 aacggctggt ccttcgatat ctggggccct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01006310             521 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:25387:8988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006310
VERSION     KCXD01006310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 521)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 521)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:25387:8988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    156..519
                     /note="immunoglobulin heavy chain variable region"
     V_region        156..519
     V_segment       156..442
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <438..>488
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64792.1"
                     /translation="CAVGYSGRWNNWYFNLW"
     D_segment       450..467
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..519
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        520..>521
                     /gene="IGHG"
BASE COUNT          130 a          147 c          142 g          102 t
ORIGIN      
        1 acatggggga ggtaaataca gatctgtcct tgtccagaga gcatcacaca acaaccacat
       61 ccctccccta cagaagcccc agagcatagc acctcaccat ggactggacc tggaggatcc
      121 tcctcttggt ggcagcagct acaggcgccc actctgaggt ccaggtggtg cagtctgggg
      181 ctgaggtgaa ggagcctggg gcctcagtga aggtctcctg caaggtttcc ggatacacct
      241 tcaccgaatt atccatgcac tgggtgcgac aggcccctgg gaaagggctt gagtggatgg
      301 gaagtgttga tcctctatat ggtgaaatga aacacacaga gttccatgcc agattcacca
      361 tgaccgagga cacgtctaca gacacggcct acatggagct gagcagccta agatcagagg
      421 acacggccct gtattactgt gcagtcggat atagcggcag atggaacaac tggtacttca
      481 atctctgggg ccctggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01006311             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13787:15608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006311
VERSION     KCXD01006311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13787:15608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64793.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       442..447
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          118 c          158 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggttca gctggtggag tctggaggag gcttgggtca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttaagtcgca
      301 tgatggaact aagaagtact acgcagactc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aacatggtat atcttcacat gaacaacctg aaattagaag acacggccgt
      421 gtattactgt gtgagagatg cctacggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006312             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19393:8082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006312
VERSION     KCXD01006312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19393:8082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64794.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          109 a          116 c          156 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccagtt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgaagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactttcct gcgcagcctc tggattcagc ttcaattatt actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta atagtggtgg
      301 ggaaagtacg tactatgcag agtccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctatttcttc aaatggacag cctgagaact gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006313             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:12928:4182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006313
VERSION     KCXD01006313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:12928:4182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..489
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64795.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       411..432
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT           98 a          142 c          134 g          117 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg cagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gtggctctat cagcagtact aaatggtgga gctggatccg ccagccccca gggaaagggc
      241 tggagtggat tgggtatatc agtggtagta gtggtaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca acggacacgt ccaacaacca gttttccctg aagctgagct
      361 ctgtgaccgc cgcggacacg gccgtttatt attgtgcgag atcccaatcc tattgtagtg
      421 ggctttactg cttcggctac tactactttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006314             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22347:16466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006314
VERSION     KCXD01006314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22347:16466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..457
     V_segment       106..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64796.1"
                     /translation="CASLLNPSSDSW"
     D_segment       404..409
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           87 a          134 c          136 g          102 t
ORIGIN      
        1 acatggggaa aaaggtctct gagagtcacg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggtagctccc agatgggtcc tgtcccaggt gcagctgcag
      121 gagtcgggcc caggactggt gaagtcttcg gagaccctgt ccctcacctg cgctgtttct
      181 ggtggctcca tcaggggtta ctggtggggc tggatccggc agtccccagg gaagggtctg
      241 gagtggattg gctatatcgg tggcagtagt gggagcacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccaga tttccctgaa gctgacctct
      361 gtgaccgccg cggacacggc cgtgtattcc tgtgcgagtc ttctaaaccc ttcgagtgac
      421 tcctggggcc agggagtcct ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01006315             527 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12832:17604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006315
VERSION     KCXD01006315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12832:17604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..525
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..525
     V_segment       144..436
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>494
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64797.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       451..470
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       483..525
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        526..>527
                     /gene="IGHG"
BASE COUNT          114 a          132 c          154 g          127 t
ORIGIN      
        1 acatgggagc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag tgtgaggtgc aactggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttacg
      241 acatgacctg ggtccgccag gctccgggaa aggggctgga atgggtctca tatattagtt
      301 acactggtaa aaccatatac tactctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgccaa gaactctctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattattg ttctagagcg gcttacgaac atgatgacgg ttactattac gtcggcaggt
      481 tttttgactg ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006316             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15129:14558
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006316
VERSION     KCXD01006316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15129:14558"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64798.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          105 a          121 c          157 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagtcccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagtctc tggattcagt ttcagtcact acttcatgag
      241 ctgggtccgc caggctccag ggaagggact ggagtggatc tcagggatta acagtggtgg
      301 agataccaca cactatgcag actccgtgaa gggcagattc accatgtcca gagagaacgc
      361 caagaacaca ctgtcccttc aaatggacgg cctgagagct gaagactcgg ctgtctatta
      421 ttgtgcgaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006317             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22123:14501
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006317
VERSION     KCXD01006317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22123:14501"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..484
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64799.1"
                     /translation="CARYFNYEDDYGYSNTGGTDAFDFW"
     D_segment       395..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..484
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           95 a          137 c          135 g          119 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg tggctccatc
      181 agcaatagct tctggagctg gatccgccag cccccaggga cggggctgga gtggattggc
      241 tatatctttg gtggtactgg gagcaccaac tacaatccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggt tgacctctgt gaccgcctcg
      361 gacaccgccg tgtattactg tgcgagatat ttcaattacg aggatgatta cggttactct
      421 aacaccggtg gtactgatgc ttttgatttc tggggccaag gtctcagggt caccgtctct
      481 tcagcc
//
LOCUS       KCXD01006318             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16527:10048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006318
VERSION     KCXD01006318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16527:10048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..343
     V_segment       7..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64800.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       271..283
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..343
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           77 a           87 c          108 g           73 t
ORIGIN      
        1 acatgggggg cctcagtaaa ggtctcctgc caggtttccg gatacacctt cagtgaaatg
       61 tccatgcact gggtgcgaca ggcccctgga aaagggcttg agtggatggg atgtgttgct
      121 cctggaaatg gtgaaataat acacgcagag aacttccagg gcagagtcac catgaccgag
      181 gacacgtcta cagacacagc ctacatggag ctgagtagcc tgagatctga ggacacggcc
      241 gtgtattact gtgcgacagg gaggttcggg agcagcgtct ggtccagcct cttctacggt
      301 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006319             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18970:12741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006319
VERSION     KCXD01006319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18970:12741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64801.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          118 c          148 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggggga ggcttcgttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agaaactttg
      241 gcatacactg ggtccgccag gctccaggga agggcctgga gtgggtggca gtcatttcgt
      301 ctgatggaac taagatatac tacgcaaact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgagtaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatcttggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006320             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6925:19491
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006320
VERSION     KCXD01006320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6925:19491"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..473
     V_segment       107..398
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64802.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       404..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          142 c          131 g          108 t
ORIGIN      
        1 acatgggggc tgtctgagag tcagggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag gtcccagatg ggtcctgtcc cagccgcagc tgcagctgca
      121 ggagtcgggc ccaggactgg tgaaaccttc ggagaccctg tccctcgcct gcgttgtctc
      181 tggtggctcc atcagcgatt actcctggag ctggatccgc cagcccccag ggaagggact
      241 ggagtggatt gggaatattg atgttcatct agcgggcccc aactacaacc cctccctcaa
      301 gagtcgagtc gccatttcaa aagacacgtc caagaatcag ttctccctga agctgagctc
      361 tgtgaccgcc gcggacacgg ccgtatattt ctgtgcgaaa caatatagtg gtagttatta
      421 ctactcccac tttgacttct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006321             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:11008:9956
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006321
VERSION     KCXD01006321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:11008:9956"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..439
                     /gene="IGHV3-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64803.1"
                     /translation="CARAFGVLIPYFDYW"
     D_segment       442..447
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          111 a          121 c          148 g          127 t
ORIGIN      
        1 acatgggggc tctgggaaag gaaccccagt cttgggattc ccagggattt tcattcggtg
       61 atcagcactg aagacagaag actcaccatg gaatttaggc tgagctgggt tttccttgtt
      121 gctgttttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggta
      181 cagcctgggg actccctgag actctcttgt acaggctctg gattctcctt cagtaactac
      241 tacatgtact gggtccgcca ggctccaggg aaggggctgg agtgggtctc atctattgat
      301 actggtgggg ataccacaag gtacacagac tccgtgaagg gccgattcac catctccaaa
      361 gagaacgcca agaacacact gtatcttcaa atggacagcc tgagagctga ggacacggct
      421 gtctattact gtgcgagagc ttttggagtc cttatcccgt actttgacta ctgggcccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006322             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:19732:16260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006322
VERSION     KCXD01006322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:19732:16260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64804.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          106 a          124 c          155 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattgccgct
      301 gatggggata gcacatacta tgcagactcc atgaaggcca gattcactat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagcagagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctga tcaccgtctc ctcagcc
//
LOCUS       KCXD01006323             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14788:18488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006323
VERSION     KCXD01006323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14788:18488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..486
     V_segment       123..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64805.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       417..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          119 a          140 c          135 g           94 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca ggtggtgcag tctggggctg aggtgaagga gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctgggaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaaac
      301 acacagagtt ccatgccaga ttcaccatga ccgaggacac gtctacagac acggcctaca
      361 tggagctgag cagcctaaga tcagaggaca cggccctgta ttactgtgca gtcggatata
      421 gcggcagatg gaacaactgg tacttcgatc tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01006324             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:6815:3246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006324
VERSION     KCXD01006324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:6815:3246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64806.1"
                     /translation="CASNSITSGPDYW"
     D_segment       399..405
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           85 a          141 c          130 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag gcacggacat cctgtgcaag aacatgaggc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cgcctgcagc tgcgggcggc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctctc acctgcgctg tctctggtgg
      181 ctctatcagc ggtaactact ggagctggat ccgccgggcc ccagggaagg gactggagtg
      241 gattggatat atctacggta gtgattttac caccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagcagata cgtccaagaa ccagctctcc ctgaacctgg cctctgtgac
      361 cgccgcggac acggccgtct atttctgtgc cagtaatagt ataacatctg gtccagatta
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006325             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13534:13018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006325
VERSION     KCXD01006325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13534:13018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..469
     V_segment       100..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64807.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       400..411
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           91 a          141 c          136 g          103 t
ORIGIN      
        1 acatggggtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc tttggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccatcagca gtaactactg ggcctggatc cgccagcccc cagggaaggg actggagtgg
      241 attggacgta tctctggtag tggtgggagc accgtctaca acccctccct caagagtcga
      301 gtcaccattt caactgacac gtccaagaac caggtctccc tgaaagtgac ttctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg acagccggat atagcagcag cgaaagcttc
      421 tacggtttgg attcctgggg ccaaggggtc gtcgtcatcg tctcctcagc c
//
LOCUS       KCXD01006326             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20073:7417
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006326
VERSION     KCXD01006326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20073:7417"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64808.1"
                     /translation="CARGETASVYYALDSW"
     D_segment       440..451
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          131 c          155 g          114 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatacactgg gtccgccagg ctcccgggaa ggggctggag tgggtctcag ccattagtag
      301 tggtggtagc acatactacg cagactccat gaagggccga gccaccatct ccagagacaa
      361 ctcaaagaac acggtctccc tgcaagtgaa cagcctgact tctgaggaca cggccgtgtt
      421 ttactgtgcg agaggggaga cagcttcagt ttactacgct ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006327             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10471:7955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006327
VERSION     KCXD01006327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10471:7955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64809.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       441..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          112 c          155 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtatt tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaaa tcgtttgatg
      301 gaactaagat atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcctac gggagcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006328             434 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20857:20786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006328
VERSION     KCXD01006328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 434)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 434)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20857:20786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..432
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..432
     V_segment       78..371
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <363..>401
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64810.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       381..386
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..432
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        433..>434
                     /gene="IGHG"
BASE COUNT          100 a           95 c          131 g          108 t
ORIGIN      
        1 acatgggcag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
       61 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      121 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcatac
      181 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      241 aaactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      301 ccaaaaacat ggtatatttt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      361 actgtgcgag agatgtcagg ggaacgggat ttgacttctg gggccaggga gtcctggtca
      421 ccgtctcctc agcc
//
LOCUS       KCXD01006329             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:25701:10632
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006329
VERSION     KCXD01006329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:25701:10632"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64811.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          143 c          130 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctgcactggg tgcgacaggc
      241 tcctggaaaa ggacttgagt ggatgggagg tgttcatcct gaatatggta aagtggacta
      301 cacacagaag ttccgagaca gactcaccat caccgcggac atgtcgacag agacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact actggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006330             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11057:6612
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006330
VERSION     KCXD01006330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11057:6612"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64812.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          118 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccat gaacatggta tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006331             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15729:8348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006331
VERSION     KCXD01006331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15729:8348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..486
     V_segment       126..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64813.1"
                     /translation="CATADSGYPFYYFDFW"
     D_segment       421..428
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          117 a          141 c          129 g          101 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggcg cagtctgggg ctgacgtgaa gaagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaaggactt gagtggatgg gaggttttgc tcctatatat ggtgaaataa
      301 tacacgcaaa gttccagggc agagtcagtt tgaccgagga cacgtccaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ctattattgt gcgacagctg
      421 atagcggtta cccattttac tacttcgatt tctggggccc tggtacccca atcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01006332             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17881:4006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006332
VERSION     KCXD01006332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17881:4006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64814.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          122 a          143 c          133 g           96 t
ORIGIN      
        1 acatgggaga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaaccctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacatct taaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctcaatat ggtgaaatga
      301 tagacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacttgga gctgagcagt ctgagatctg aggacacggc cgtgtattac tgtgcgacct
      421 catccagcgg cacctggcta tactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01006333             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18131:17034
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006333
VERSION     KCXD01006333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18131:17034"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64815.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          108 a          146 c          133 g           92 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaagtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcag gatttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctgtatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac ttggaactga
      361 gcggcctgac ttctgaggac acggccgtgt attactgtgc gactggccct accggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01006334             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:23342:13695
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006334
VERSION     KCXD01006334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:23342:13695"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64816.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       442..448
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          110 c          153 g          118 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcacct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgaagc ctctggattc accttcagta gttatggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tatcgtatga
      301 tgtaagtaag aaatactacg cagacgctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac acgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttattgtggg agagatgata atggggtgct tatcgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006335             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18542:10875
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006335
VERSION     KCXD01006335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18542:10875"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64817.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          142 c          149 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgagatcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcc aggtgtccgg atacacgttc agtgaaatct ccatgcactg ggtgcgacag
      241 acccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagtagcct gagatctgac gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006336             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13714:13310
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006336
VERSION     KCXD01006336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13714:13310"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64818.1"
                     /translation="CATSPSGSWLFWYFDFW"
     D_segment       424..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          113 a          144 c          139 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg agatttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacgcagaaa ggttccaggg cagagtcacc ttgaccgaag acacgtctac aggaacggcc
      361 tacatggagc tgatcagcct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca gctggctatt ttggtacttc gatttctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006337             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13294:4001
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006337
VERSION     KCXD01006337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13294:4001"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64819.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       438..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          137 c          153 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgcgaggtgc acctggtgga gtctgggggc ggcctggcaa
      181 agcctggggg agccctgagc ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga atgggtctca gctattagta
      301 gtggtggcac cacatactac gcagactccg tgaagggccg attcaccgtc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccgtgt
      421 tttactgtgc gaaagccgat acagctacac catactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006338             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19301:8511
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006338
VERSION     KCXD01006338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19301:8511"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64820.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          115 c          157 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggtttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga atgggtggca gttgaatcgt
      301 ttgatggagg taagaaatac tacgctgact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006339             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8679:4972
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006339
VERSION     KCXD01006339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8679:4972"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64821.1"
                     /translation="CTRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          118 c          149 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctactttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagcaatat tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tttattactg tacgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006340             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22673:13871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006340
VERSION     KCXD01006340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22673:13871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64822.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       421..429
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          143 c          132 g          102 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc cgaagtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aaggtttccg gacacacctt cagcgaatta tccattcact gggtgcgaca
      241 ggcccccgga aaagggcttg agtgggtggg aggttttgct cctatatatg gtgaaatcct
      301 acacacagac aagttccagg gcagagtcac cttgaccgag gacacgtcta cagacaccgc
      361 ctatatggag ttgagcagcc tgagatctga ggacacggcc gtatattact gtgtggcggc
      421 tgatagtggt tacccttttt actacttcga tatctggggc cctggcaccc caatcatcat
      481 ctcctcagcc
//
LOCUS       KCXD01006341             324 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16138:1955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006341
VERSION     KCXD01006341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 324)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 324)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16138:1955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    10..322
                     /note="immunoglobulin heavy chain variable region"
     V_region        10..322
     V_segment       10..261
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <253..>291
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64823.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       272..281
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..322
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        323..>324
                     /gene="IGHG"
BASE COUNT           74 a           81 c           93 g           76 t
ORIGIN      
        1 acatgggggg gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtaat
       61 tttggcatcc actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata
      121 tcgtctgatg aaagtaagaa atactatgca gactctgtga aggaccgatt caccatctcc
      181 agagacaatt ccaagaacat ggtttatctt cagatgaaca acctgaagtt ggacgacacg
      241 gccgtctatt actgtgcgag agacgcattt ggcagcggct gtgacttctg gggccaggga
      301 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006342             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6458:13346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006342
VERSION     KCXD01006342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6458:13346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64824.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          111 c          155 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgttattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttatg tcgtctgatg
      301 gaactaagac attctacgca gactctgtga aggtccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca gcctgaaatc ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgatta tcgactactg gggccaggga gtcctggtca
      481 ccgtcgcctc agcc
//
LOCUS       KCXD01006343             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9418:18514
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006343
VERSION     KCXD01006343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9418:18514"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64825.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          107 a          126 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttaatggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc
      301 tggtggggat accacatact atgcagactc cgtgaagggc agatccacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006344             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13401:6786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006344
VERSION     KCXD01006344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13401:6786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64826.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       448..454
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..521
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          116 a          124 c          160 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagcact gaacacaaga gactcaccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgtaggctct ggattcacct tcagtgacta
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaaatct tacaattacg cggcagaata cgccgcatcg gtgaaaggca ggttcaccgt
      361 ctccagagat gattcaaaga acacgctaca tctgcaaatg agcagcctga aaaccgagga
      421 cacggccgtg tattactgtg ctagagggga tataccggct atagaggcct actacggttt
      481 ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006345             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14308:9080
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006345
VERSION     KCXD01006345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14308:9080"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64827.1"
                     /translation="CARNRFMGVRVLAYW"
     D_segment       401..405
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           94 a          137 c          132 g          101 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtccag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cggttactac tggaactgga tccgccaacc accagggaag ggcctggagt
      241 ggattgggta tatcgctggt agtagtggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga gccaattctc cctgaagctg aactctgtga
      361 ccgccgcgga cacggccatc tattactgtg cgagaaatag atttatgggt gtaagggttc
      421 ttgcctactg gggccaggga gtcctggtcg ccgtctcctc agcc
//
LOCUS       KCXD01006346             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:13258:17495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006346
VERSION     KCXD01006346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:13258:17495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64828.1"
                     /translation="CAKTYYSGTLEFW"
     D_segment       420..432
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..477
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           95 a          146 c          130 g          108 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag ttcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtacag tctggggcag aggtgagaag gcccggggag tctctgagga
      181 tctcctgtaa gacttctgga tacagcttta ccaccagctg ggtcagttgg gtgcgccaga
      241 tgcccgggaa aggcctggag tggatgggga ccatctatcc tgctgattct gaggccaaat
      301 acaacccctc cttccaaggc cacgtcacta tctcagtcga caactccatc agtaccacct
      361 acctgcattg gagcagcctg aaggcctcgg acaccgccac atatttctgt gcgaaaacct
      421 actatagtgg tactttggag ttctggggcc agggagccct ggtcaccgtc gcctcagcc
//
LOCUS       KCXD01006347             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14091:10161
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006347
VERSION     KCXD01006347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14091:10161"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64829.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       442..448
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          121 c          149 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tggctgacag ttatatcgta
      301 tgatgaaact aagcaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acgcggccgt
      421 gtattactgt gcgagagatt cttacggtcg aggctttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006348             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24674:17973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006348
VERSION     KCXD01006348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24674:17973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    130..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        130..493
     V_segment       130..423
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <415..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64830.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       437..442
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          104 a          124 c          149 g          118 t
ORIGIN      
        1 acatggggga gcccagcccc agaattccca ggtgtttctg ttcggcgatc agcactaaac
       61 acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct tttgaaaggt
      121 gtccagtgtg aggtgcagtt aatggagtct gggggcggct tggcaaagcc tggggggtcc
      181 ctgagactct cctgcgcagc ctctggattc agcttcagtt actactacat gagctgggtc
      241 cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacgctgg tggggatacc
      301 acatactatg cagactccgt gaagggcaga tccaccatct ccagagagaa cgccaagaac
      361 acactgcatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta ttactgtgtg
      421 agagatcgac gtgttcagtc gttatcctgg ttcgatgtct ggggcccggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006349             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:23551:5742
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006349
VERSION     KCXD01006349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:23551:5742"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..481
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64831.1"
                     /translation="CARAGNAAGPSTEYFEFW"
     D_segment       417..427
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..481
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>485
                     /gene="IGHG"
BASE COUNT           99 a          151 c          143 g           92 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga ggcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga ggcccggggc ctcagtgaag ctctcctgca
      181 aggcttccgg ttacaggttc accatctatg gcatcagttg ggtgcgacag gcccctggac
      241 aaggccttga gtggatggga gggatcctcc ctcttcttgg tacagcacac tacgcacaga
      301 cgttccaggg cagagtcacc attaccgcgg acacgtccac aagcacagcc tacatggacc
      361 tgaacagcct gagatctgag gacacggccg tgtattactg tgcgagagcc ggaaacgcag
      421 ctggtccctc cacggaatac ttcgagttct ggggccaggg cgccctggtc accgtctcct
      481 ccgcc
//
LOCUS       KCXD01006350             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22470:3212
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006350
VERSION     KCXD01006350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22470:3212"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..496
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64832.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       436..443
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>502
                     /gene="IGHG"
BASE COUNT          120 a          141 c          141 g          100 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttcgtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgtaaa gtttccggat acacggtcat cgatttatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gaacatggtg aagtaatata
      301 cgcagacaac ttccagggca gagtcgccat gagcgaggac acgtctacag acacagccta
      361 catggagctg agcatcctga catctgagga cacggccgtg tattactgtg cgacccacgg
      421 aggatataga ggcatctgga actccctata ctacggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctccccag cc
//
LOCUS       KCXD01006351             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:21614:14272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006351
VERSION     KCXD01006351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:21614:14272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64833.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          109 a          124 c          154 g          128 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgagc aggggctgga gtggatctca gctattgata
      301 gtgctgctac tagtaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006352             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18762:9306
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006352
VERSION     KCXD01006352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18762:9306"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64834.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006353             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14097:8287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006353
VERSION     KCXD01006353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14097:8287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64835.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          114 c          147 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgca acctctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagagcat actatatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006354             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18382:16872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006354
VERSION     KCXD01006354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18382:16872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..437
     V_segment       83..381
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <371..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64836.1"
                     /translation="CARVVAAGVDSW"
     D_segment       386..394
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT           89 a          141 c          110 g           99 t
ORIGIN      
        1 acatggggga atcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttgt cccaggtcac cttgaaggag tctggtcctg cgctcgtgag
      121 acccacacag accctcacgc tgacctgcac cttctctggg ttctcaatcg acactctcgc
      181 aacaggtgtg ggctggatcc gtcagccccc cgggaaggcc ctccaatggc ttgcaagcat
      241 ttattggaat gatagtagat tctacatcac atcgctgaag agccggctca ccatctccaa
      301 ggacacctcc aataaccagg tggttctgac aatgaccgac atggatcctt tggacacagc
      361 cacatattac tgtgcacgcg ttgtggcagc tggtgtggac tcctggggcc agggagtcct
      421 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006355             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19131:6793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006355
VERSION     KCXD01006355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19131:6793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64837.1"
                     /translation="CARDEGDVSGYRFGYW"
     D_segment       436..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          114 c          160 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggcg tctggaggag gcttggttca
      181 gcctgggggg tccctgaaac tctcctgtgc agcctctgaa ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtt
      301 tgatggaagt aagaaatact acgcagactc tatgaaggac cgattcacca tctctagaga
      361 caattccaag aacatgctat atcttcaagt gaacaacctg agattggagg acacggccat
      421 gtattactgt gcgagggatg agggggacgt tagcgggtac cgatttggct actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006356             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7604:6539
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006356
VERSION     KCXD01006356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7604:6539"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64838.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          117 c          155 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccact gtgaagtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agtctctggg ttcaccttca gtggctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggaa tgggtggcgg ttatatcgaa
      301 tgatggaact aacaaatact acgcagactc tctgaaggac cgatttagta tctccagaga
      361 gaattccaag aacatgctat atcttcaaat gaacaacctg aaactggagg acacggccgt
      421 ctattactgc gcgacagatg cgtttggtag cgggattgac tactggggcc ggggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006357             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14408:4812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006357
VERSION     KCXD01006357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14408:4812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..468
     V_segment       89..378
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <374..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64839.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       390..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>472
                     /gene="IGHG"
BASE COUNT          108 a          129 c          138 g           97 t
ORIGIN      
        1 acatggggcc ctgggaacac agctcatcac catggacttg acctggaggc tcctctttgc
       61 ggtggcagca gctacaggtg cccagtccca ggtccaactg gtgcagtccg gggctgaggt
      121 gaagaagcct ggggcctcag tgaagctctc ctgcaaggct tctgggttca cctttagcac
      181 cgaagccatc aattgggtgc gacaggcccc tggacaagga cttgactgga tgggaggggt
      241 catccctctt atgggtacaa caaactacgc acagaagttc cagggcagag tcacgtttac
      301 cgcggacacg tccataagca cagcctacat ggagctgagc agcctgagat ctgaggacac
      361 ggccgtgtat tattgtgcca aatccgtgaa ttacgaggaa gataacggtt actatatacc
      421 gacgcagttt gactactggg gccagggagt cctggtcacc gtctcctctg cc
//
LOCUS       KCXD01006358             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12293:5580
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006358
VERSION     KCXD01006358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12293:5580"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64840.1"
                     /translation="RARDVYGCGLDYW"
     D_segment       440..445
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          114 c          153 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtccacctgg tggaatctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcgc cttcagtagg tttggcatgc
      241 actgggtccg ccagactcca ggaaaggggc tggagtgggt ggcagttatg tcgtctgatg
      301 gaagtaggat atactacgca gactctttga aagaccgatt caccatatcc agagacaatt
      361 ccaagaacat gctatatctt caactgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 accgtgcgag agatgtctat ggctgtgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01006359             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22028:12380
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006359
VERSION     KCXD01006359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22028:12380"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64841.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          114 c          155 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc ggaacctatg
      241 gcattcactg ggtccgccag gctccaggga agggcctgga gtgggtgacg gttatatcga
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacgt gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcgtttggta gcgggcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006360             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10010:10063
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006360
VERSION     KCXD01006360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10010:10063"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..494
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64842.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          113 a          118 c          153 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggcg gttatatcca
      301 atgatggaag taagaaatac tacgcagact ctctgaagga ccgattcagc atttccaggg
      361 acaaccccaa gaacatacta tatcttcaaa tgaacaacct gaaattggat gacacggccg
      421 tctattactg tgcgacagat gcgtttggta gcgggattga ctactggggc cggggagtcc
      481 tggtcaccgt ctccgcagcc
//
LOCUS       KCXD01006361             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16465:4436
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006361
VERSION     KCXD01006361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16465:4436"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64843.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       452..460
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          119 c          150 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggcg cagctggtgg aatctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcggcctctg aattcacctt cagcagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactatagtg atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006362             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:5959:11190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006362
VERSION     KCXD01006362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:5959:11190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64844.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          142 c          142 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gcacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggaattg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006363             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6772:5269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006363
VERSION     KCXD01006363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6772:5269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64845.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       423..429
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          112 a          142 c          139 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac agccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctgc aggcgcccgc
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgcg aggtttccgg atacaccttc accgaactgt ccatccactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 gacgcagaaa agttccaggg cagagtcacc ttgaccgagg acacgtctac aggaacggcc
      361 tacatggagc tgatcagcct gagatctgaa gacacggccg tgtattactg tgcgacatca
      421 cccagcggca attggctttt ttggtacttc gatttttggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006364             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:26528:14337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006364
VERSION     KCXD01006364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:26528:14337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..448
     V_segment       85..378
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64846.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       382..389
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           91 a          133 c          122 g          104 t
ORIGIN      
        1 acatgggggg acctcctgtg caagaacatg aagcacctgt ggttcttcct tctcctggtg
       61 gcagttccca gatgggtcct gtcccaggtg cagctacagg agtcgggccc aggactggtg
      121 aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtgactccat cggcaatagc
      181 tactggaact ggatccgcca gcccccaggg aagggtctgg agtggattgg gtatatctct
      241 ggtgcttatg ggatcaccag ctacaacccc tccctcaaga gtcgagtcac catttcaaca
      301 gacacgtcca agaaccactt ttccctgagg ctgagttctg tgaccgccgc ggacaccgcc
      361 gtgtattact gtgtgagata tgaggatgaa tccattaact accactttga ctactggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006365             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:17090:8328
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006365
VERSION     KCXD01006365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:17090:8328"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64847.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          113 c          146 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagaaac tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgca aactctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagaacat actttatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006366             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23308:11945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006366
VERSION     KCXD01006366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23308:11945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64848.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          140 c          152 g           99 t
ORIGIN      
        1 acatgggggc atcacataac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga ggcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgag gacacggccg tgtattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006367             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15410:13577
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006367
VERSION     KCXD01006367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15410:13577"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64849.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       448..456
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          114 c          162 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gttattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagcccgggg ggtcactgag actgtcctgt gcagcctctg gattcacctt cagtagctct
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg agtgggaggc acttatatct
      301 aatgatggaa gtaagaaata ttacgcagac tccgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct gtatcttcaa atgaacaacc tgaaattgga tgacacggcc
      421 gtgtattact gtgcgcgagt tggagagggt agtggtggtg cggaggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006368             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23490:6308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006368
VERSION     KCXD01006368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23490:6308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..457
     V_segment       106..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64850.1"
                     /translation="CASNSITSGPDYW"
     D_segment       401..407
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           87 a          141 c          129 g          102 t
ORIGIN      
        1 acatggggat gttctctgag aggcacggac atcctgtgca agaacatgag gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccgcctgca gctgcaggcg
      121 gcgggcccag gactggtgaa gccttcggag accctgtctc tcacctgcgc tgtctctggt
      181 ggctctatca gcggtaacta ctggagctgg atccgccggg ccccagggaa gggactggag
      241 tggattggat atatctacgg tagtgatttt accaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagcaga tacgtccaag aaccagctct ccctgaacct ggcctctgtg
      361 accgccgcgg acacggccgt ctatttctgt gccagtaata gtataacatc tggtccagat
      421 tactggggcc ggggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006369             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23601:6030
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006369
VERSION     KCXD01006369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23601:6030"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64851.1"
                     /translation="CARSGSGTWNGWYLDLW"
     D_segment       423..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          139 c          140 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccag
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctgggac ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccattcattg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga actattgatc ctctttatgg tgaaatgata
      301 cacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agatacagcc
      361 tacatggagc tgaggagcct gagatctgag gacacggccg tatattattg tgcgaggtcg
      421 ggtagcggca cttggaacgg ctggtacctc gatctctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006370             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17383:4541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006370
VERSION     KCXD01006370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17383:4541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64852.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          114 a          144 c          129 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctgcactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtgttcatc ctgaatatgg taaagtagac
      301 tccatacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggacc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga ctactggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006371             371 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:18740:4249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006371
VERSION     KCXD01006371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 371)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 371)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:18740:4249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..369
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..369
     V_segment       8..281
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <273..>338
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64853.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       286..307
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       319..369
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        370..>371
                     /gene="IGHG"
BASE COUNT           80 a          103 c          105 g           83 t
ORIGIN      
        1 acatgggggg cccaggactg atgaagcctt cagagaccct gtccctcagc tgcgctgtct
       61 ctggtggctc cataagtggt aactggtgga gctggatccg ccagccccca gggaagggac
      121 tggactggat tggacgtatc tctggtacta gtggggacac caattacaat ccctccctca
      181 agagtcgagt caccatttca acagacacgt ccaagaacca cttctccctg aagctgaact
      241 ctgtgaccgc cgcggacgcg gccgtgtatt attgtgcaag agcggattac gaggatgatt
      301 acggttatca tttaggatac aactggttcg atgtctgggg cccgggagtc ctggtcaccg
      361 tctcctcagc c
//
LOCUS       KCXD01006372             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22827:14393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006372
VERSION     KCXD01006372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22827:14393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64854.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          127 c          156 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactacttc
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaccagt
      301 ggtggggcta acacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga ccacactgta tcttcacatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg taagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006373             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7283:12578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006373
VERSION     KCXD01006373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7283:12578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..485
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64855.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       429..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT           95 a          149 c          133 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggctactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggcat atcagtggga gtagtgggag caccgactac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaacagaca cgtccaagag ccacttctcc ctgaaactga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagttt tccccctacg actactcttg
      421 gagtgatttt tactcatact actttgacta cttgggccag ggactcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01006374             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:26813:12224
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006374
VERSION     KCXD01006374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:26813:12224"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64856.1"
                     /translation="CARSWGGLLSPEYFDFW"
     D_segment       447..452
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..508
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          116 a          116 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt gcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggaa cagctggtgg agtctgaggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattagc
      301 attggcggta gaacaaacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aatgacaaga aagacttgta tcttcaaatg aagagcctga gagctgagga cacggcagtg
      421 tatttttgtg ccagaagttg ggggggttta ctaagcccgg aatacttcga tttctggggc
      481 cagggcgccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006375             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14757:6651
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006375
VERSION     KCXD01006375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14757:6651"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64857.1"
                     /translation="CTRDVYGSGFDYW"
     D_segment       439..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          107 a          108 c          151 g          126 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagttggtg gagtctggag gaggcttggt tcagcctcgg
      181 gggtccctga gactctcctg tgtagcctct ggattcacct tcagtagtta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc gtctgatgga
      301 agtaggatat attacgcaga ctctgtgaag ggccgattca tcatctccag agacaattcc
      361 aagaacatgg tctatcttca aatgaacaac ctgaaatttg acgacacggc cgtgtattat
      421 tgtaccagag atgtgtacgg tagtgggttt gactactggg gcctgggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006376             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14351:9260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006376
VERSION     KCXD01006376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14351:9260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64858.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          121 c          146 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt tagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006377             369 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20582:14681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006377
VERSION     KCXD01006377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 369)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 369)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20582:14681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..367
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..367
     V_segment       8..279
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <271..>336
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64859.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       289..310
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       320..367
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        368..>369
                     /gene="IGHG"
BASE COUNT           76 a          106 c           98 g           89 t
ORIGIN      
        1 acatgggcag gactggtgca gccttcggag accctgtccc tcacatgcgc tgtctctggt
       61 ggctctatca gcagtactaa atggtggagc tggatccgcc agcccccagg gaaagggctg
      121 gagtggattg ggtatatcag tggtagtagt ggtaacacct actacaaccc ctccctcaag
      181 agtcgagtca ccatttcaac ggacacgtcc aacaaccagt tttccctgaa gctgagctct
      241 gtgaccgccg cggacacggc cgtttattat tgtgcgagat cccaatccta ttgtagtggg
      301 ctttactgct tcggctacta ctactttgac tactggggcc agggagtcct ggtcaccgtc
      361 tcctcagcc
//
LOCUS       KCXD01006378             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13042:14606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006378
VERSION     KCXD01006378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13042:14606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..478
     V_segment       112..403
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64860.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       409..429
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           97 a          142 c          132 g          109 t
ORIGIN      
        1 acatggggga aatgctgtct gagagtcagg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcaggtccc agatgggtcc tgtcccagcc gcagctgcag
      121 ctgcaggagt cgggcccagg actggtgaaa ccttcggaga ccctgtccct cgcctgcgtt
      181 gtctctggtg gctccatcag cgattactcc tggagctgga tccgccagcc cccagggaag
      241 ggactggagt ggattgggaa tattgatgtt catctagcgg gccccaacta caacccctcc
      301 ctcaagagtc gagtcgccat ttcaaaagac acgtccaaga atcagttctc cctgaagctg
      361 agctctgtga ccgccgcgga cacggccgta tatttctgtg cgaaacaata tagtggtagt
      421 tattactact cccactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006379             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:16908:9765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006379
VERSION     KCXD01006379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:16908:9765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64861.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       434..445
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          135 c          149 g          106 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtggagtc cggggctgag gtgaagaagc ctggggcctc agcgaagctc
      181 tcctgcaagg ccgctggata cattttcagt acctctgcca tcagttggct gcgacaggcc
      241 cctggacaag ggcttgagtg gatggggggg atcatgcctc ttgttggtag aacaaactac
      301 gcacagaggt tccagggcag agtcacgatt accgcggaca cgtccacaag gacagccaac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc gagcggtggt
      421 ttccaggatg agaacggtta ctattttcca gactattttg acttttgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006380             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22185:8230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006380
VERSION     KCXD01006380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22185:8230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64862.1"
                     /translation="CARDSYGSGSDYW"
     D_segment       435..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          108 a          120 c          143 g          116 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgaa ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc cgggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt acttttggca tccactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg atggaaataa
      301 cctatactac gcagactctc tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 catggtgtat cttcaaatga acaacctgaa attggaggac acggccgtct attactgtgc
      421 gagagattca tatggcagcg gctccgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01006381             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9991:3463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006381
VERSION     KCXD01006381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9991:3463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..494
     V_segment       131..424
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64863.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       438..443
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          124 c          150 g          118 t
ORIGIN      
        1 acatgggggg agcccagccc cagaattccc aggtgtttct gttcggcgat cagcactaaa
       61 cacagaacat accatggagt ttgtgctgag ctgggttttc cttgttgctc ttttgaaagg
      121 tgtccagtgt gaggtgcagt taatggagtc tgggggcggc ttggcaaagc ctggggggtc
      181 cctgagactc tcctgcgcag cctctggatt cagcttcagt tactactaca tgagctgggt
      241 ccgccaggct ccagggaagg ggctggagtg gatctcaggt attaacgctg gtggggatac
      301 cacatactat gcagactccg tgaagggcag atccaccatc tccagagaga acgccaagaa
      361 cacactgcat cttcaaatgg acagcctgag agctgaggac acggctgtct attactgtgt
      421 gagagatcga cgtgttcagt cgttatcctg gttcgatgtc tggggcccgg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006382             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:12876:14375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006382
VERSION     KCXD01006382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:12876:14375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64864.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       423..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          143 c          142 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctgggtct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atccaccttc accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgctc ctctatatgg tgaaatgatg
      301 cacgcagaca acttccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgac gacacggccg tgtattactg tgcgcgtggg
      421 cctattacaa tttttggcgt acttattacg gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006383             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10078:10791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006383
VERSION     KCXD01006383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10078:10791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64865.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       435..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          103 a          123 c          154 g          112 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacacaccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc attgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctaa gactctcctg tgcagcatcc ggattcagct tcagtgacca ctgcatgcac
      241 tgggtccgcc aggcttcagg gaaggggctg gagtgggtct caggtattac ttatactggt
      301 gttaccacat ggtacgcaga ctccgtgagg ggcagattca ccatctccag agagaacgcc
      361 aagaacacac tgtatcttca aatggacagc ctgagacctg aggacacggc tgtctattac
      421 tgtgtgggag gaaggcggca cgtggacctt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006384             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14700:3955
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006384
VERSION     KCXD01006384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14700:3955"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..496
     V_segment       139..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64866.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       437..442
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..496
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          121 c          151 g          115 t
ORIGIN      
        1 acatgggggg ggacaggagc ccagccctgg aagaccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgaact gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcaactg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattcc ccttcagtag ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagtcat ttcgtacgac
      301 gaaactaaga aatactacgc agactctctg gaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctttatct tcagatgaac aacctgaaat tggaggacac ggccgtttat
      421 tactgtgcgc ggaggccctg gagtgcagat gcctttgatt tctggggcca aggactcagg
      481 gtcaccgtct cttcagcc
//
LOCUS       KCXD01006385             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:24829:7764
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006385
VERSION     KCXD01006385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:24829:7764"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64867.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       446..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          110 a          118 c          151 g          119 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgtggct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctggaggagg cttggttcgg
      181 cctggggggt ccctgagact ctcctgtgca gtctctggat tcaccttcag taattttggc
      241 atccactggg tccgccaggc tccagggaag ggcctggagt gggtggcagt tatatcgtct
      301 gatgaaagta agaaatacta tgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatgctata tcttcaaatg aacaacctga acttggagga cacggccgtc
      421 tattactgtg cgagggacgc atttggcagc ggctgtgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006386             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:23564:8006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006386
VERSION     KCXD01006386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:23564:8006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64868.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       448..453
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          153 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag agcacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct
      241 ggcatgcact gggtccgcca gactccaggg aaggggctgg agtgggtggc agttaaatcg
      301 tttgatggaa ctaagatata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacattct atatcttcaa atgaacaacc tgaaattgga agacacggcc
      421 gtttattact gtgtgaggga tgcctacggg agcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006387             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19194:20311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006387
VERSION     KCXD01006387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19194:20311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64869.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           90 a          133 c          139 g           99 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctggg caagaacatg aggcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gatgtctcgg
      181 ggggctccat cagtagtggt tatggctgga gctggatccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtctc tacgatagta gtggaaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca aaagacacgt ccaagaacca gttctccctg aagctgaggt
      361 ctatgaccgc cgcggacgcg gccgtgtatt tctgtgcgag atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006388             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17587:10513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006388
VERSION     KCXD01006388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17587:10513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64870.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          140 c          134 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacaccacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa gtccaaggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcgtc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcgtcagcc
//
LOCUS       KCXD01006389             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11802:3904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006389
VERSION     KCXD01006389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11802:3904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..484
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64871.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       412..429
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..484
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          141 c          139 g          106 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag
      121 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct
      181 gtctctggtg gctccttcag cggttactac tggagctgga tccgccagcc cccagggaag
      241 gggctggagt ggattggata tatcagtgct agtagtggga ccaccgacta caacccctcc
      301 ctcaagagtc gagtcaccat ttcaagagac acgtccaaga acctcttctc cctgaacctg
      361 agctctgtga ccgccgcgga cacggccgtg tattactgtg cgagagagaa atactatagt
      421 ggtagttata aacacaactg gttcgatgtc tggggcccgg gagtcctggt cgccgtctcc
      481 tcagcc
//
LOCUS       KCXD01006390             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18067:4350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006390
VERSION     KCXD01006390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18067:4350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64872.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       443..450
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          118 c          149 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttcag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatt
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 tcgatgacaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01006391             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18440:18007
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006391
VERSION     KCXD01006391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18440:18007"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64873.1"
                     /translation="CARDESSINYPFDYW"
     D_segment       409..415
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           91 a          141 c          127 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcaac ttcaggagtc
      121 gggcccagga caggtgaggc cttcggagac cctgtccctc acctgcgctg tctctcgtgg
      181 ctccatcagt ggttacaggt ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgc atctctggta gtggtgggag caccacctac aaccccttcc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtttaacaa ccagttctcc ctgaacctga gctctgtgac
      361 cgccgcagac acggccgtct atttctgtgc gagagatgag agctccatta actacccttt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006392             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12591:10751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006392
VERSION     KCXD01006392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12591:10751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64874.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       446..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcttctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgcctg gctccaggga aggggctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattgaag gacacggccg
      421 tgtactactg tgggagagat gataatgggg tgattatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006393             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9161:16293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006393
VERSION     KCXD01006393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9161:16293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64875.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          114 c          148 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt cttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 ggggctccct gagactctcc tgtgcagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaagtaagaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgcaatt ggaggacacg gccgtatatt
      421 actgtgcgag agatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006394             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:16010:7295
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006394
VERSION     KCXD01006394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:16010:7295"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64876.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       435..441
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          108 a          125 c          154 g          115 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacaca ccatggagtt tgtgctgagc tggattttcc ttgttgctct
      121 tttgaaaggt gtccggtgtg aggtgcaact ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcactt actactacat
      241 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      301 tgggcatagc acatactatg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga attgaggaca cggctgtcta
      421 ttactgtgcg agagtagtgg gtggtgccgc aggatacttc gacttctggg gccagggcgc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006395             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20084:14431
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006395
VERSION     KCXD01006395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20084:14431"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64877.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       359..364
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..410
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           87 a           93 c          128 g          104 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtatctc tggcatgcac tgggtccgcc aggctccagg
      181 gaaggggctg gagtgggtgg cagtaaaatc gtttgatgga actaagatat actacgcaga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatgc tatatcttca
      301 aatgaacaac ctgaaattgg aggacacggc cgtttattac tgtgtgagag atgcctacgg
      361 gagcggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006396             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13171:14922
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006396
VERSION     KCXD01006396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13171:14922"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..514
     V_segment       133..426
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <418..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64878.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       436..442
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          109 a          117 c          155 g          135 t
ORIGIN      
        1 acatggggga gccacagccc cgggattccc agctgtctcc acttggtcat gaacactgaa
       61 ctcagaagac gcaccatgga gtttgtgctg agtttgcttt tccttgttgc ttttttaaaa
      121 ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggtaaa gcctgggggg
      181 tccctgagac tctcttgtgt agtctctgga ttctccttca gtaactatgt tatgcattgg
      241 gtccgccagg ctccaggaaa gggtctggag tgggtctcac ttattagtgg aagtggtggt
      301 accacagact acgcagactc tgtgaagggc cgattcaccc tctccagaga caacgccaag
      361 gaatcgcttt ttctgcaaat gaacagccta agagccgagg acacggccgt gtattactgt
      421 gctagaggcg gggaaatagt ggattcagag attattgagg attactacgg tttggatttc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006397             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18364:3090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006397
VERSION     KCXD01006397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18364:3090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64879.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          151 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttacatcgt
      301 ctgatgaaag taagaaatac tatgtagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatagta tatcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga ctactggggc cggggcgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006398             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9988:6536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006398
VERSION     KCXD01006398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9988:6536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64880.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          112 c          152 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccaatcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 tacgaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa attctacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006399             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:25696:12738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006399
VERSION     KCXD01006399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:25696:12738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..453
     V_segment       99..391
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <384..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64881.1"
                     /translation="CARRPWDSDAFDFW"
     D_segment       397..401
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       408..453
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>458
                     /gene="IGHG"
BASE COUNT          105 a          105 c          137 g          111 t
ORIGIN      
        1 acatggggtc ggtgatcagc acagaacaca gaggactcac catgaagttt gggctgagct
       61 gggttttcct tgttgctatt ttaagaggtg tccagtgtga ggtgcagctg gtggagtccg
      121 gaggaggctt ggttcagccg ggggggtccc tgagactctc ctgtgcagcc tctggattca
      181 ccttcagtaa ctatggcatg cactgggtcc gccagcctcc agggaagggg ctgcagtggg
      241 tggcagttat atcgtacgat gaagataaga aatactacgc agactctctg aaggaccgat
      301 tcaccatctc cagagacaat tccaagaaca tgctatatct tcaaatgaac aacctgaaat
      361 tggaggacac ggccgtgtat tactgtgcga ggaggccctg ggattcagat gcttttgatt
      421 tctggggcca agggctcagg gtcaccgtct ctttagcc
//
LOCUS       KCXD01006400             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22857:7117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006400
VERSION     KCXD01006400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22857:7117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64882.1"
                     /translation="CAGAHSGSWTNWSFDLW"
     D_segment       420..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          115 a          140 c          144 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga gggtcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag ccaggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat attcggtcac cgaagtgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct ctatatggtg aaataataga
      301 aggagagaag ttcccgggca gagtcaccat gaccgaggac acgtccacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cgggagccca
      421 tagcggcagc tggaccaact ggtccttcga tctctggggc cctggcactc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006401             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:24947:9912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006401
VERSION     KCXD01006401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:24947:9912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64883.1"
                     /translation="CTRDKGVYLRYFEFW"
     D_segment       448..452
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..505
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          127 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagcttgtgg agtctggggg aggcttggtc
      181 cagcctggag ggtccctgag actctcctgt gcagcctctg gattcatctt cagaaattac
      241 ggcatgagct gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacacaggtg aaaccatata ctatgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacccggcc
      421 gtgtattatt gtactagaga taagggagta tatctccgtt acttcgagtt ctggggccag
      481 ggcgccctgg ccaccgtctc ctcagcc
//
LOCUS       KCXD01006402             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13786:12923
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006402
VERSION     KCXD01006402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13786:12923"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64884.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          116 c          145 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatttcgtc
      301 tgatggaact aacaaatact acgcaaactc tgtgaagagc cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006403             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11947:9182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006403
VERSION     KCXD01006403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11947:9182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64885.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       447..455
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          115 c          158 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc acacggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 ttttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctggggc tctcctgtgc agcctctgga ttcaccttca gtcactatgg
      241 cgttcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaaat aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaag accatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gtgagagatg tcagaggcgg tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006404             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6981:15084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006404
VERSION     KCXD01006404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6981:15084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64886.1"
                     /translation="CARVLGYNNKYEVTRGRLDYW"
     D_segment       437..444
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          141 c          140 g           99 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aacctctcct
      181 gcaaggcttc tggatacccc ttcaacatct atgccatcaa ttgggtgcga caggcccctg
      241 gacaagggct tgagtggatg ggagggatca tccctcttgt tggcatgaca aactacgcac
      301 agaagttcca gggcagagtc accattaccg cggacacgtc cacaagtaca gcctacatag
      361 aactgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga gtcttagggt
      421 acaataacaa gtacgaagtt accaggggcc gtcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006405             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25701:9117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006405
VERSION     KCXD01006405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25701:9117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64887.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       446..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          103 a          122 c          162 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc gacttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg ctgcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctcg ggtattgaca
      301 gtggtggggg taccacatac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccga gaacacactg tatcttcaaa tggacagcct gacagctgag gacacggctg
      421 tctattactg tgcgagagtc gtgggtggta gtgctggata ctttgactac tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006406             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:7893:9466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006406
VERSION     KCXD01006406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:7893:9466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64888.1"
                     /translation="CARVRGAATGFFDHW"
     D_segment       451..458
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          109 a          120 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcgcta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtaca gctggtggag tctgggggcg gcttggcgaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca attacttcta
      241 cataagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgacag
      301 tggtggggat accacatact atgcagactc cgtaaagggc agattcatca tctccagaga
      361 gaatgccaag aatacactgt atcttcaaat ggacaacctg agagctgagg acacggctgt
      421 ctattattgt gcgagagtga gaggggcagc gactggtttc tttgaccact ggggccaggg
      481 agtcctcgtc accgtctcct cagcc
//
LOCUS       KCXD01006407             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:22777:11501
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006407
VERSION     KCXD01006407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:22777:11501"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64889.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           95 a          134 c          129 g          109 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcac ctgcaggagt
      121 cgggcccagg actggtgaag tcttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 actccatcag caatagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006408             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21941:3618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006408
VERSION     KCXD01006408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21941:3618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..360
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..360
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64890.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       305..310
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       314..360
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        361..>362
                     /gene="IGHG"
BASE COUNT           78 a           83 c          116 g           85 t
ORIGIN      
        1 acatgggggt gcagctggtg gagtctggag gcggcttggt tcagcctggg gggtccctga
       61 gactctcctg tgtagcctct ggattcacct tcagtagtag tggcatgcac tgggtccgcc
      121 aggctccagg gaaggggctg gagtggctgg ctgttgaatc gcatgatgga aataagaaat
      181 actatgcaga ctccgtgaag gaccgattca ccatctccag agacaattcc aagaacatgg
      241 tatatcttca aatgagcaac ctgaaattgg tggatacggc catgtattac tgtgtgagag
      301 atgcctacgg gggcggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag
      361 cc
//
LOCUS       KCXD01006409             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:4949:10454
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006409
VERSION     KCXD01006409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:4949:10454"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64891.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       453..457
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          104 a          124 c          157 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tcttgccagt
      301 ggtggggata gcacatacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagttgaaga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcattatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006410             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11366:16863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006410
VERSION     KCXD01006410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11366:16863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64892.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       447..453
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          114 c          151 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctg
      121 ttttaagagg tgtccagtgt gaggtacagc tggtggagtc tggaggagac ttggttcagc
      181 cgggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      301 atggaagtaa gacatactac gcaaactctg tgaaggaccg attcaccata ttaagagaca
      361 attccaagag catgctctat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagacgat atgggaagtg gctttgacta ctggggcccg ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006411             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11791:5047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006411
VERSION     KCXD01006411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11791:5047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64893.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       410..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          117 a          139 c          133 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaggtg gtgcagtctg gggctgaggt gaaggagcct ggggcctcag cgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcta tatggtgaaa tgaaacacac
      301 agagttccat gccagattca ccatgaccga ggacacgtct acagacacag cctacatgga
      361 gttgagcagc ctaagatctg aggacacggc cctgtattat tgtgcagtcg ggtatagcgg
      421 ccgatggaac aactggtact tcgatctctg gggccctggc accccaatca ccatctcctc
      481 agcc
//
LOCUS       KCXD01006412             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20355:12105
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006412
VERSION     KCXD01006412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20355:12105"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64894.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       435..445
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>514
                     /gene="IGHG"
BASE COUNT          118 a          151 c          143 g          102 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctccccaac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg acttgttgat cctgttaatg gtgacctaat
      301 acacgcagac aagttccagg gcagagtcac catgaccgaa gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgacatctga ggacacggcc atctactact gtgcgacagg
      421 gaggatcggt accagtggct ggtccaacct cttcaatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagtctcttc agcc
//
LOCUS       KCXD01006413             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21204:11424
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006413
VERSION     KCXD01006413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21204:11424"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64895.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          116 c          156 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cgttcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc aatacttttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtcatatcga
      301 atgatggagg taataaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacgtgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006414             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:7367:14013
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006414
VERSION     KCXD01006414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:7367:14013"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..511
     V_segment       136..427
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64896.1"
                     /translation="CVRERFGGIGVIIFNWIDVW"
     D_segment       463..469
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..511
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          110 a          122 c          159 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggta tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcacctggtg cagtctgggg gcggcctgac aaagcctggg
      181 gggtccctga gactctcctg tgcagcctcc ggattcacct tcagtgacta ctatatggac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtct cacgaatcgg tcatgatggt
      301 ggtttcacat ggtacgcaga ctccgtgaag ggcagattta ccatttccag agagagtgcc
      361 aagaacacac tgtttcttca aatggacagc ctgagaagtg acgacacagc cgtatattac
      421 tgtgtgagag agcggtttgg gggaattggg gtaataatct tcaactggat cgatgtctgg
      481 ggcccgggag tcctggtcac cgtcccctca gcc
//
LOCUS       KCXD01006415             397 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13974:10143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006415
VERSION     KCXD01006415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13974:10143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..395
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..395
     V_segment       20..311
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>364
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64897.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       331..342
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       354..395
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        396..>397
                     /gene="IGHG"
BASE COUNT           84 a           94 c          129 g           90 t
ORIGIN      
        1 acatgggggt gtccagtgtg aggtgcacct ggtgcagtct gggggcggct tgacaaagcc
       61 tggggggtcc ctgagactct cctgtgcggc ctccggattc accttcagtg actactatat
      121 ggactgggtc cgccaggctc cagggaaggg gctggagtgg gtctcacgaa tcagtcatga
      181 tggtgatagc acatggtacg cagactccgt gaagggcaga tttaccattt ccagagagaa
      241 tgccaagaac acactgtttc ttcaaatgga cagcctgaga agtgaggaca cagccgtata
      301 ttactgtgcg agagagcgtt ttgggggaat tggggtgatt atcttcaact ggatcgatgt
      361 ctggggcccg ggagtcctgg tcaccgtccc ctcagcc
//
LOCUS       KCXD01006416             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22587:7156
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006416
VERSION     KCXD01006416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22587:7156"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64898.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       420..426
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          138 c          144 g          100 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat actgtatctg atggagtgat
      301 atacgcagaa aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattatt gtgcgagagg
      421 tgtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006417             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7935:8757
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006417
VERSION     KCXD01006417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7935:8757"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    69..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        69..441
     V_segment       69..365
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64899.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       373..380
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           84 a          125 c          130 g          104 t
ORIGIN      
        1 acatggggaa catgaagcac ctgtggttct tcctcctcct ggtggcagct cccagatggg
       61 tcctgtccca ggtgcagctg caggagtcgg gcccaggact ggtgaagcct tcagagaccc
      121 tgtccctcac ctgcgctgtc tctggaggct ctatcagcgg tggttatgac tggagctgga
      181 tccgccagcc cccagggagg gggctggagt ggattgggta tatctatggt agtcgtgggg
      241 gcgccaccta caacccgtcc ctcaggaatc gagtcaccat ctcaaaagac acgtcccaga
      301 accagttgtc cctgaagctg aactctgtga ccgtcgcgga cacggccgta tattattgtg
      361 cgagacagtg ctgttactat gatgactttt tagactactt tgatttctgg ggccagggag
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006418             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22346:5536
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006418
VERSION     KCXD01006418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22346:5536"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64900.1"
                     /translation="CSRGSNYEDASDYFSAFDSW"
     D_segment       415..426
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          137 c          140 g          107 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctgatgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctttg ccatcaattg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg gataacaaac tacgtgcaga
      301 agttccaggg cagagtcacc attaccgcgg acacgtccac aagtatagcc tacatggagc
      361 tgagcggcct aagatctgag gacacggccg tgtattactg ttcgagaggg tcaaattacg
      421 aggatgcttc cgattacttt tccgcctttg actcctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006419             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10648:8320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006419
VERSION     KCXD01006419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10648:8320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64901.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          125 c          160 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttatgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgcg gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattagcag
      301 tggtggggat gacacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag accacactgt atcttcaaat ggacagcctg acagctgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttgtcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006420             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12286:18078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006420
VERSION     KCXD01006420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12286:18078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64902.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          116 c          149 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatttcga
      301 atgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006421             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10953:18171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006421
VERSION     KCXD01006421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10953:18171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64903.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       441..446
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          117 a          115 c          150 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga gctgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcacgttca gtaactatgg
      241 aatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggagtgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01006422             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9764:7000
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006422
VERSION     KCXD01006422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9764:7000"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..483
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64904.1"
                     /translation="CARRGYNNADDWYFDFW"
     D_segment       412..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..483
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          108 a          145 c          136 g           96 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggactggac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccaactggt gcagtccggg gctgaggtga aggagcctgg ggcctcagtg aagctctcct
      181 gccaggcttc tggatacacc ttcggcatct acgccatcaa ttgggtgcga caggcccctg
      241 gacaagggct tgagtggatg ggagggatca cccctcttat tggcttaaca aactacgcac
      301 agaagttcca gggcagagtc acgctcaccg cggacacgtc cacaagtaca gtctacatcg
      361 agttgaacag cctgagatct gaggacacgg ccgtgtattt ctgtgcgaga cgtggataca
      421 acaacgctga cgactggtac ttcgatttct ggggccctgg caccccgatc accgtctcct
      481 cagcc
//
LOCUS       KCXD01006423             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14794:17165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006423
VERSION     KCXD01006423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14794:17165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..481
     V_segment       121..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64905.1"
                     /translation="CATADSGYPFYYFDFW"
     D_segment       416..423
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          116 a          140 c          127 g          100 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggcgcagtc tggggctgac gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgtaagg tttccggata caccttcacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag gacttgagtg gatgggaggt tttgctccta tatatggtga aataatacac
      301 gcaaagttcc agggcagagt cagtttgacc gaggacacgt ccacagacac agcctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtctatt attgtgcgac agctgatagc
      421 ggttacccat tttactactt cgatttctgg ggccctggta ccccaatcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01006424             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13185:20253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006424
VERSION     KCXD01006424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13185:20253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64906.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          125 c          158 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attacttcta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt ttcttcaaat ggacagcctg acagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006425             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18127:15909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006425
VERSION     KCXD01006425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18127:15909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..515
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64907.1"
                     /translation="CAKRGWAGSWNGGHYFDYW"
     D_segment       449..461
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..515
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>518
                     /gene="IGHG"
BASE COUNT          107 a          131 c          163 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggtcc
      181 agcctggggg gtctctgaga ctctcctgtt cagcctctgg attcactttc agtagctatt
      241 ccatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattacta
      301 atggtggtgt taccacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcgat ggacacgctc tccctgcaaa tgaacagcct gagagctgag gacacggccg
      421 tgtattactg tgcgaaaaga gggtgggccg gcagctggaa cggggggcac tactttgact
      481 attggggcca gggagtcctg gtcaccgtct cctcaccc
//
LOCUS       KCXD01006426             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:5336:14574
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006426
VERSION     KCXD01006426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:5336:14574"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..400
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64908.1"
                     /translation="CARWGDSQSIYYFDFW"
     D_segment       401..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          137 c          133 g          109 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg
      181 tgactctatt accagtagta gctggtggaa ctggatccgc cagcccccag ggaaagggct
      241 ggaatggatt ggttatatca gtggtactag tgggagcacc gactatcacc cctccctcaa
      301 gagtcgagtc accatttcaa cagacacgtc caagaaccag tttaccctga cgttgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga tggggcgact cccagtccat
      421 ttactacttt gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006427             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:7456:10657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006427
VERSION     KCXD01006427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:7456:10657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64909.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       414..423
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          143 c          135 g          102 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc ggtagttact ggtggacctg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gaaatagtgg tagtacctac tatagcccct ctctcaagag
      301 tcgagtcacc atttcaaaag acgcgtccaa gaaccacctc tccctgaagc tgaactctgt
      361 gaccaccgcg gacacggccg tgtatttctg tgcgaacgtc ttaggcccct ggggcagctg
      421 gtcacactac tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006428             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22112:8647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006428
VERSION     KCXD01006428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22112:8647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64910.1"
                     /translation="CARGPGCTNSDCNGEAFDFW"
     D_segment       425..431
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..489
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          111 a          136 c          145 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctatg acatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttgg aacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattactg tgccagaggc cccgggtgta
      421 ctaatagtga ttgcaacggg gaggcttttg atttctgggg ccaagggctc agggtcaccg
      481 tctcttcagc c
//
LOCUS       KCXD01006429             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:3962:11540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006429
VERSION     KCXD01006429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:3962:11540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64911.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       445..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          112 a          115 c          147 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcga
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 cggaggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt ttctatggct
      241 tccactgggt ccgccaggct ccagggaagg gactggagtg ggtggcagtt atttcgaatg
      301 atgaaaataa caaatactac gcagactcta tgaaggaccg attcaccatt tctagagaca
      361 attccatgaa catgctattt cttcaaatga acaacctgaa cttggacgac acggccgtct
      421 attactgtgt gagagatgat ttaggcagcg gcttagggtc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006430             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21849:4331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006430
VERSION     KCXD01006430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21849:4331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64912.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          114 c          150 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgcg gttggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggat tgggtggcag ttacgtcgtt
      301 tgatgaaaat gtgaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtattactgt gcgagagggg aatatagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006431             350 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:11911:3550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006431
VERSION     KCXD01006431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 350)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 350)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:11911:3550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..347
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..347
     V_segment       4..287
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>317
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64913.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       291..297
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       306..347
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        348..>350
                     /gene="IGHG"
BASE COUNT           84 a           82 c           99 g           85 t
ORIGIN      
        1 acatggggga gtctggagga ggcttggttc aacctggggg gtccctgaga ctctcctgtg
       61 cagcctctgg attcaccttc agaaattttg gcatacactg ggtccgccag gctccaggga
      121 aggggctgga gtgggtggca gttatttcgt ctgatggaag taacaaatac tacgccaact
      181 ctgtgaagag ccgattcacc atttccagag acaattccaa gagcatacta tatcttcaaa
      241 tgaacaactt gaaattggag gacacggccg tctattactg tgcgagagat gatattggga
      301 ccggttttga ctactggggc cagggagtcc tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01006432             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14150:15834
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006432
VERSION     KCXD01006432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14150:15834"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64914.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          142 c          136 g           99 t
ORIGIN      
        1 acatggggag catcacacaa cagccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagctg caggcgcccg
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc gaggtttccg gatatacctt caccgaactg tccattcatt gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aagtgttgat cctgaatatg gtgaaatgat
      301 aaacgcagaa aaattccagg gcagagtcac cttgaccgag gacacgtcta caggaacggc
      361 ctacatggac ctgatcagtc tgagatctga agacacggcc gtgtattact gtgcgacatc
      421 acccagcggc acctggctat attggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006433             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:7973:10392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006433
VERSION     KCXD01006433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:7973:10392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64915.1"
                     /translation="CARPPYWGDPGDVW"
     D_segment       410..418
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..464
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           89 a          138 c          137 g          102 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacacga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcgatggtt acaggtggac ctggattcgc cagcccccgg ggaagggact
      241 ggagtggatt gggtacatct atggtagtaa tgcggacacc aactacaacc cctccctcaa
      301 aagtcgagtc actatttcaa aagacacgtc caggaaccag ttctccttga agttgaactc
      361 tgtgaccgcc gcggacacgg ccgtctattt ctgcgcgagg cccccgtatt ggggtgatcc
      421 aggcgatgtc tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006434             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7391:12964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006434
VERSION     KCXD01006434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7391:12964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64916.1"
                     /translation="CARDEDPSIFEYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           93 a          134 c          131 g          104 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt ggtaccacct actacaagtc ctccctcaag
      301 agtcgagcca ccatttcaaa agacacgtcc aacaatcaac tctccctgaa gttgagttct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gaatactggg gccagggagt cctggtcacc gtctcttcag cc
//
LOCUS       KCXD01006435             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18080:12037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006435
VERSION     KCXD01006435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18080:12037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64917.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       266..272
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           80 a           74 c           92 g           74 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
       61 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      121 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      241 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006436             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:12472:15416
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006436
VERSION     KCXD01006436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:12472:15416"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64918.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       402..415
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           90 a          132 c          141 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acttgcgttg tctctggcca
      181 ctccatcagc agtggctacc actggggctg gatccgtcag cccccaggga agggactgga
      241 ctatattggc tatatcagtg gtagtagtgg gagcacctac tacaagccct ccctcatgag
      301 tcgagtcatc atttcaagag acacgtcccg gaatgagttc tccctgaggc tgaggtctgt
      361 gactgtcgcg gacacggccg tgtattattg tgcgagacga gatagctgga acaacggggg
      421 gagccttgac tactggggcc agggattcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006437             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15287:18921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006437
VERSION     KCXD01006437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15287:18921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..472
     V_segment       100..396
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64919.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       404..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          135 c          135 g          112 t
ORIGIN      
        1 acatggggtt ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcagagacc ctgtccctca cctgcgctgt ctctggaggc
      181 tctctcagcg gtggttatga ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatctatgg tggtactggg agcaccacct acaacccgtc cctcaggaat
      301 cgagtcacca tttcaaaaga cacgtccaag aaccagttgt ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt atattattgt gcgagacagt gctgttacta tgatgacttt
      421 ttagactact ttgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006438             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16313:18595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006438
VERSION     KCXD01006438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16313:18595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64920.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          103 a          126 c          154 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact acttcatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta ccagtggtgg
      301 gactaacaca tactctgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaccaca ctgtatcttc acatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtaaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006439             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:26247:19098
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006439
VERSION     KCXD01006439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:26247:19098"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64921.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       442..456
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          116 c          146 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtcc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaaact ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacacactt tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ctggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006440             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16423:10684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006440
VERSION     KCXD01006440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16423:10684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..469
     V_segment       94..387
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <379..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64922.1"
                     /translation="CARYGADYEDDYDYYSFDYW"
     D_segment       398..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           96 a          131 c          134 g          110 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacttgcg ctgtctctgg tgactccatc
      181 accagtagct tctggagctg gatccgccag cccccaggga agggactgga gtggattgga
      241 tatatctatg gaagtactgg gagcaccggc tacaacccct ccctcaagag tcgagtctcc
      301 atttcaatag acacgtccaa gagccagttt tccctgaagt tgagctctgt gaccgccgca
      361 gacaccgcca tgtatttctg tgcgagatat ggggcggatt acgaggatga ttacgattac
      421 tatagttttg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006441             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14235:8198
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006441
VERSION     KCXD01006441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14235:8198"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64923.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          117 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttc
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctgggga gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtct gtaatttcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaactccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006442             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:19024:15364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006442
VERSION     KCXD01006442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:19024:15364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64924.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          141 c          135 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggg agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006443             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19753:6287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006443
VERSION     KCXD01006443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19753:6287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..336
     V_segment       1..266
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64925.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       270..277
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           73 a           96 c           89 g           80 t
ORIGIN      
        1 gactggtgaa gtcttcggag accctgtccc tcacctgcgg tgtctctggt gactccatca
       61 gcaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag tggattgggt
      121 atatctctgg tgcttatggg agcaccagct acaatccctc cctcaagagt cgagtcacca
      181 tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg accgccgcgg
      241 acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac cactttgact
      301 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006444             386 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5705:17973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006444
VERSION     KCXD01006444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 386)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 386)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5705:17973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..384
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..384
     V_segment       145..323
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <315..>353
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64926.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       334..342
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       343..384
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        385..>386
                     /gene="IGHG"
BASE COUNT           96 a           84 c          116 g           90 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cacacggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggctc cagggaaggg gctggagtgg gtggcagtta
      181 tatcgtatga tgaaaataag aaatactacg cagactctgt gagggaccga ttcaccatct
      241 ccagagacaa ttccaagacc atggtatatc ttcaaatgaa caacctgaaa ttggaggaca
      301 cggccgtgta tttctgtgtg agagatgtca gaggcggtgg ctttgactac tggggccagg
      361 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006445             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:9440:5400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006445
VERSION     KCXD01006445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:9440:5400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..481
     V_segment       100..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <385..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64927.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       398..402
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           96 a          145 c          134 g          108 t
ORIGIN      
        1 acatggggtt ctctgagagt cacagacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtggc
      181 tccttcagca cttcctactg gagctggatc cgccaggccc cagggaaggg actggagtgg
      241 attggatata tctatgctga tagtgggacc accagctaca acccgtccct caagagtcga
      301 gtcaccattt caatagacac gtccaagaat ctgtactccc tgaaactgag ctctgtgacc
      361 gccgcggaca cggcctttta ttactgtgcg agacgtccta ctcgcacgcg ggttctatat
      421 gaggcgacag gggaagactt tgactcctgg ggccagggac tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01006446             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14766:19025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006446
VERSION     KCXD01006446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14766:19025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..410
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64928.1"
                     /translation="CVRERGEDGGAGIPHYFDYW"
     D_segment       435..442
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          144 c          141 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagccgc ctggggcctc agtgaaactc
      181 tcctgcaaga cttctggata cagcttcagc atctatgcca tccattgggt gcgtcaggcc
      241 cctggacaag gccttgagtg gatgggacgg atcgtccctc ttgttggtat gacaaactac
      301 gcacagaagt tccaggacag agtcacactt accgcggaca cgtccacaag gacagcctac
      361 atggaactga gcagcctgag atctgacgac acggccttct attattgtgt acgagagagg
      421 ggcgaagatg ggggagctgg aatcccccac tactttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006447             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12709:3241
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006447
VERSION     KCXD01006447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12709:3241"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64929.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       441..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          115 a          114 c          156 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatgtcg
      301 aatgatggaa ctaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacaggct atatcttcaa atgaacaacc tgaaattgga ggacacggca
      421 gtctattact gtgcgagaga tgatagtggg gtgatcatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01006448             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24478:8433
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006448
VERSION     KCXD01006448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24478:8433"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..510
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64930.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       437..450
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..510
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          111 a          120 c          163 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccaggcct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttggtctgac ctgggttttc cttgttggtc
      121 ttttgaaagg tgtccagtgt gaggtgcagc tggtggagtc tggaggagcc ttggctcagc
      181 ctggggggtc cctgagactc tcctgtgcag cgtctgggtt caccttcagt agctatgcca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagcc atatcgtttg
      301 atggaagtaa gaagaactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 actccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 actactgttc gagggagtgg atacagtggg cgcagttagt gagcggtttg gattcctggg
      481 gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006449             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12251:18178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006449
VERSION     KCXD01006449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12251:18178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64931.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          139 c          135 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa gtccaaggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcgtc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcgtcagcc
//
LOCUS       KCXD01006450             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6132:15468
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006450
VERSION     KCXD01006450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6132:15468"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64932.1"
                     /translation="CATGRFGSSVWSTLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          142 c          149 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgagatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga catctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccaccctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006451             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15901:10086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006451
VERSION     KCXD01006451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15901:10086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64933.1"
                     /translation="CATDAFGSGIDHW"
     D_segment       444..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          114 c          157 g          115 t
ORIGIN      
        1 atggggagct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggaga cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgcg gcctctggat tcaccttcag aacctatggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcggt tatatcgaat
      301 gatgaaacta acaaatacta cggagactct gtgaagggcc gattcagcat ctccagagac
      361 aattcgaaga acatgctata tcttcaaatg aacaccctga aattggagga cacggccgtg
      421 tattactgtg cgacagatgc gtttggtagt gggattgacc actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006452             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15498:15147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006452
VERSION     KCXD01006452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15498:15147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..341
     V_segment       8..280
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <272..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64934.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       284..296
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           81 a           82 c           98 g           82 t
ORIGIN      
        1 acatggggga ggaggcttgg ttcagcctgg ggggtccctg agactctcct gtgcagcctc
       61 tggattcacc ttcagtaact atggcatgca ctgggtccgc caggctccag ggaaggggct
      121 ggattgggtg gcagttatgt cgtttgatga aaatgtgaaa ttctacgcag actctgtgaa
      181 ggaccgattc accatctcca gagacaattc caagaacatg ctatatcttc aaatgaacaa
      241 cctgaaattg gaggacacgg ccctgtatta ctgtgcgaga ggggaataca gtaactctat
      301 tgacttctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006453             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14036:8980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006453
VERSION     KCXD01006453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14036:8980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..373
     V_segment       7..298
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <292..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64935.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       312..318
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       324..373
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           89 a           99 c          107 g           80 t
ORIGIN      
        1 acatgggagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
       61 aaggtctcct gcaaagtttc cggatacacc ttcaccgaat tatcattgca ctgggtgcgc
      121 caggcccctg gaaaagggct tgagtgggtg ggaagtgttg accctgcata tggtgaaatg
      181 atacacacag agatattcca gggcagaatc accatgaccg aggacacgtc aacagacaca
      241 gcctacatgg agctaagcag cctgagatct gaggacacgg ccgtttatta ctgtgcgata
      301 tcatccagcg gcacctggct attctggtac ttcgatgtct ggggccctgg ctccccaatc
      361 accatctcct cagcc
//
LOCUS       KCXD01006454             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:9118:11657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006454
VERSION     KCXD01006454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:9118:11657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..487
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64936.1"
                     /translation="CAREFSPYDYVWSDFYSYYFDYL"
     D_segment       412..418
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT           95 a          145 c          135 g          114 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccttca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggc atatcagtgg gagtagtggg agcaccgact acaacccctc ccacaaaagt
      301 cgagtcatca tttcaacaga cacgtccaag agccacttct ccctgaaact gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagagt tttcccccta cgactatgtt
      421 tggagtgatt tttactctta ctactttgac tacttgggcc agggactcct ggtcaccgtc
      481 tcctcagcc
//
LOCUS       KCXD01006455             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:5574:13369
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006455
VERSION     KCXD01006455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:5574:13369"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64937.1"
                     /translation="CARWEAASFDYW"
     D_segment       405..409
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           85 a          131 c          137 g          106 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccgtca gcggtggtta tggctggagc tggatccgcc aggccccagg gaagggactg
      241 gagtggattg ggagtatcta tggtcatagt ggtagcaccc gctacaatcc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgacctct
      361 gtgaccgccg cggacacggc cgtgtatttc tgtgcgagat gggaagctgc ctcttttgac
      421 tactggggtc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006456             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7322:2999
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006456
VERSION     KCXD01006456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7322:2999"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64938.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          139 c          149 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggactga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagagc ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gtcaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006457             306 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20555:14059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006457
VERSION     KCXD01006457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 306)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 306)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20555:14059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..304
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..304
     V_segment       9..243
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <235..>273
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64939.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       252..258
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       259..304
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        305..>306
                     /gene="IGHG"
BASE COUNT           75 a           81 c           84 g           66 t
ORIGIN      
        1 acatggggct cctgccaggc ttctggatac accttaaccg accactacct gcactgggtg
       61 cgacaggctc ctggaaaagg acttgagtgg atgggagggg ttcatcctga atatggtaaa
      121 gtagactaca cacagaagtt ccaagacaga gtcaccatca ccgcggacat gtcgacagag
      181 acagtctaca tggagttgag cagcctgaga tctgaggaca cggccgttta ttactgtgtg
      241 acagtaggtc cctaccatta ctttgacttc tggggccagg gagccctggt caccgtctcc
      301 tcagcc
//
LOCUS       KCXD01006458             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16094:17963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006458
VERSION     KCXD01006458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16094:17963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64940.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       427..434
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          105 a          138 c          146 g          101 t
ORIGIN      
        1 acatggggga tcacataaca accacgtccc tcctctaaag aagcccctgg gaacacagct
       61 catcaccatg gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca
      121 gtcccaggtc cagctggtgc agtccggggc tgatgtgaag aagcctgggg cctcagtgaa
      181 gctctcctgc aaggcttctg gattcgcctt cagaatgtat gccctcagtt gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg agggatcgtc cctcttgttg gaacaacaaa
      301 ctccgcacag aagttccagg gcagagtcac gattaccgcg gacacgtcca caagcacagt
      361 ctacatggag ttgagcagcc tgagatctga ggacacggcc atgtattact gtgcgagagg
      421 cctgggtagc agcgcccact ttggtttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01006459             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16987:16983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006459
VERSION     KCXD01006459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16987:16983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..438
     V_segment       84..377
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <369..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64941.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       378..383
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT          102 a          122 c          128 g           88 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggctcctc ctcttggtgg
       61 cagcagctac aggcgcccac tccgaggtcc agctggtaca gtctggggct gaggtgaaga
      121 agcctggggc ctccgtgaaa atctcctgcc aggcttctgg atacacctta accgaccact
      181 acctgcactg ggtgcgacag gctcctggaa aaggacttga gtggatggga ggtgttcatc
      241 ctgaatatgg taaagtagac tacacacaga agttccgaga cagagtcacc atcaccgcgg
      301 acatgtcgac agagacagcc tacatggagc tgagcagcct gagatctgag gacacggccg
      361 tttattactg tgtgacagtg ggtccctacc attactttga ctactggggc cagggagccc
      421 tggtcaccgt ttcctcagcc
//
LOCUS       KCXD01006460             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8857:7299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006460
VERSION     KCXD01006460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8857:7299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64942.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          139 c          138 g           96 t
ORIGIN      
        1 acatggggat ccaacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatggtgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctatagac acagcctaca tggagttgag
      361 cagcctgaga tctgaggaca cggccgtgta ttactgcgcg attggcccta gcggcaactg
      421 gaacggctgg tccttcgata tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006461             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:28988:12310
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006461
VERSION     KCXD01006461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:28988:12310"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64943.1"
                     /translation="CARGTTHLEMATGIGDYFDSW"
     D_segment       438..446
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          145 c          144 g           98 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cggctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atccatggca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttgattt aacacactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgcccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggcctttt attactgtgc gagagggaca
      421 acccacctcg agatggcaac tggaatcgga gactactttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006462             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:19895:9981
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006462
VERSION     KCXD01006462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:19895:9981"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64944.1"
                     /translation="CARVVGGAAGYLDFW"
     D_segment       431..437
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          106 a          125 c          157 g          111 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 ggatagcacc taccatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caggaacaca ctgtatcttc aaatggacag cctgagagct gacgacacgg ctgtctatta
      421 ctgtgcgaga gtggtaggtg gtgccgcagg atacctcgac ttctggggcc agggcgcact
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006463             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14952:3411
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006463
VERSION     KCXD01006463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14952:3411"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64945.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       424..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          118 a          144 c          136 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ttctgaggtc cagctggtgc aatctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctttatatg gtgaaatgat
      301 acacacagaa cagttccagg gcagagtcac cctgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcgagtgg
      421 ccctagcggc agctggaacg actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006464             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:20410:4576
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006464
VERSION     KCXD01006464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:20410:4576"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64946.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          123 a          139 c          137 g           96 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccaggtggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      301 atagacgcag agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagtag tctgagatct gaggacacgg ccgtgtatta ctgtgcgaca
      421 tcatccagcg gcacctggct atactggtac ttcgatatct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01006465             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20630:15991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006465
VERSION     KCXD01006465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20630:15991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..482
     V_segment       113..409
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64947.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       425..432
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          103 a          142 c          133 g          106 t
ORIGIN      
        1 acatggggca catgggaaat gttctctgag agtcatggac ctcctgtgca agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgaa
      121 gctgcaggag tcgggtccag gactggtgaa gccttcagag accctgtccc tcacctgcgc
      181 tgtctctgga ggctctatca gcggtgttta tgactggacc tggatccgcc agcccccagg
      241 gaaggggctg gagtggattg ggtatgtcca tggtgatact gggaacaccg actacaaccc
      301 gtccctcaag aatcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgac
      361 gctgaggtct gtgaccgccg cggacacggc cgtatattac tgtgcgagac gcccagaaaa
      421 cagttactac ttctactact ttgactactg gggccacgga gccctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01006466             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20970:16337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006466
VERSION     KCXD01006466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20970:16337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64948.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          123 a          141 c          128 g           97 t
ORIGIN      
        1 acatgggggc aacacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtgtccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcctga gtggatggga agttttaatc ctatatatgg tgaaatatta
      301 cacacagaga cattccaggg cagactcacc atgaccgggg acacgtctac agacacggcc
      361 tacatggaac tgagaagcct gatatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggtacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01006467             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:11595:8647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006467
VERSION     KCXD01006467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:11595:8647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64949.1"
                     /translation="CASGGYEDDSGFYFPDFFDSW"
     D_segment       423..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          107 a          136 c          145 g          116 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 ctctcctgca aggctgctgg atacatcttt agtatctctg ccatcagttg ggtgcgacag
      241 gcccctggac agggacttga gtggatggga gggatcatcc ctcttgttgg tgtaacaaat
      301 aacgcacgga agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc
      361 ttcatggatc tgagcagcct gagatctgag gacacggccg tctattattg tgcgagcggt
      421 ggttacgagg atgattccgg tttttatttt ccagacttct ttgactcctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006468             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:22356:21096
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006468
VERSION     KCXD01006468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:22356:21096"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..493
     V_segment       103..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64950.1"
                     /translation="CARDAGYGDTISLVDINMFPHFDYW"
     D_segment       414..437
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          101 a          134 c          140 g          120 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctggaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgtgc tgtctctggt
      181 gcctccatca gtagttactg gtggagttgg atccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg taatagtggt agtatttact acaacccttc cctcatcagt
      301 cgagtctcca tttcaaaaga cgcgtccaag aatcagttct ccctgaagct aagctctgtg
      361 accgccgcgg acacggccgt ctattactgt gcgagagatg ccgggtatgg ggatacgata
      421 tcactagtcg atattaatat gtttccccac tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006469             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12824:12418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006469
VERSION     KCXD01006469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12824:12418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64951.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       431..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          103 a          126 c          157 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcccg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagtacata ctacgcagac tccgtgaggg gccgattcac catctccaga gacaactcag
      361 agaacacgct ctccctgcac atgaacagcc tgacagctga ggacacggcc gtgtattact
      421 gtgcgaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caagggttcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006470             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22067:6718
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006470
VERSION     KCXD01006470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22067:6718"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64952.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       427..433
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          138 c          152 g          100 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga gacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgcaagtgat gaagtaatac
      301 acgcagatgg tttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcggcctg agatctgagg acacggccgt gtattactgt gcgagaggga
      421 ggttcggtag tagcgtctgg tccaatctcg tctatggttt cgattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006471             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14812:14581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006471
VERSION     KCXD01006471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14812:14581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..486
     V_segment       126..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64953.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       414..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          115 a          134 c          133 g          106 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggact tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggcg cagtctgggg ctgacgtgaa gaagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacacct tcaccgaatt atccctgcac tgggtgcgac
      241 agggccctgg aaaaggactt gagtggatgg gaggttttgc tcctatatat ggtgaattaa
      301 tccatgaaag gttccaggga agagtcagtt tgaccgagga cacgtctaca gacacagcct
      361 atatggagct gagcagcctg agatctgagg acacggccat gtattattgt gcggcagctg
      421 acagtggtta cccattttac tacttcgata tttggggccc tggcacccca atcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01006472             337 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22092:17168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006472
VERSION     KCXD01006472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 337)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 337)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22092:17168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..335
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..335
     V_segment       8..273
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <266..>304
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64954.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       280..291
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..335
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        336..>337
                     /gene="IGHG"
BASE COUNT           67 a           99 c           97 g           74 t
ORIGIN      
        1 acatggggga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
       61 ctctatcagc atttactact ggaattggat ccgccaggcc ccagggaagg gactggactg
      121 gattggacat atctatggta gcggtgatag caccaacttc aacccctccc tcaagagtcg
      181 agtcaccctg tcagtagaca cgtccaagaa ccagttctcc ctgaacctga ggtctgtgac
      241 cgccgcggac acggccgtat attactgtgc gagcggtcgg cggcagctgg actttgacta
      301 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006473             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17112:13152
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006473
VERSION     KCXD01006473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17112:13152"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64955.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       444..456
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          110 c          158 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggctgggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcaacg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgatatcgt
      301 ttgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc gtctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tgtattactg tgtgagagac tcttatggaa gtggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006474             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9581:15961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006474
VERSION     KCXD01006474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9581:15961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64956.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          122 c          159 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtattg acagtggtgg
      301 ggatagcaca tactatgcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aattggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006475             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13951:6992
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006475
VERSION     KCXD01006475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13951:6992"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64957.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          118 a          113 c          154 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccaatcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgtgagaga tgtcagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006476             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16214:16311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006476
VERSION     KCXD01006476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16214:16311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64958.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          116 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttcttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg ctccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaag taagaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gcaattggag gacacggccg
      421 tatattactg tgcgagagat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006477             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:23514:14526
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006477
VERSION     KCXD01006477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:23514:14526"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64959.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       408..413
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           96 a          137 c          128 g          103 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtccag ttgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cggttactac tggaactgga tccgccaacc accagggaag gggctggagt
      241 ggattgggtt tatcgctggt agtagtggga ccaccaacta caacccctcc ctcaagagtc
      301 gagtcaccat ctcaacagac acgtccaaga accagttctc cctgaacctg aactctgtga
      361 ccgccgcgga cacggccatg tattactgtg cgagaaatag atttatgggt attagagttc
      421 ttgcctactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006478             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:24167:16496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006478
VERSION     KCXD01006478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:24167:16496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64960.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          114 a          143 c          132 g           92 t
ORIGIN      
        1 acatgggggg catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtaga
      301 ctacacacag aagttccgag acagagtcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tttcctcagc
      481 c
//
LOCUS       KCXD01006479             291 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:8547:11466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006479
VERSION     KCXD01006479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 291)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:8547:11466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..289
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..289
     V_segment       8..206
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <199..>258
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64961.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       209..233
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..289
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        290..>291
                     /gene="IGHG"
BASE COUNT           65 a           74 c           85 g           67 t
ORIGIN      
        1 acatgggatg gcatgcactg ggtccgccag gctccgggaa agggactgga gtgggtctca
       61 tccatcagta atactggtaa agccgtacac tacgctgact ccgtgaaggg ccgattcacc
      121 atttccagag acaacgccaa gaactcgctg tctctgcaaa tgagcagcct gagagccgag
      181 gacacggccg tgtattattg ttgtagcgat tactatagtg gtagttatta ctattggggc
      241 tacggcttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006480             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16709:13164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006480
VERSION     KCXD01006480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16709:13164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64962.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          114 c          157 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggtttggttc
      181 agcctggggt gtccctgaga ctctcttgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccagggc aggggctgga ttgggtggca gttgaatcgt
      301 ttgatggagg taagaaatac tacgctgact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006481             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11286:16702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006481
VERSION     KCXD01006481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11286:16702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64963.1"
                     /translation="CATGRIGGSGWSNLFTGLESW"
     D_segment       432..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          148 c          147 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgt caggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctggg aaagggcttg agtggatggg agttgttgat cctgtcaatg gtgaagaaat
      301 tcacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcggt ggcagcggct ggtccaacct cttcaccggt ttggaatcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006482             416 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:24172:15874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006482
VERSION     KCXD01006482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 416)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 416)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:24172:15874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    42..414
                     /note="immunoglobulin heavy chain variable region"
     V_region        42..414
     V_segment       42..338
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <330..>383
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64964.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       346..353
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       367..414
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        415..>416
                     /gene="IGHG"
BASE COUNT           82 a          116 c          122 g           96 t
ORIGIN      
        1 acatgggcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
       61 cgggcccagg actggtgaag ccttcagaga ccctgtccct catatgcgct gtctctggag
      121 gctctatcag cggtggttat gactggagct ggatccgcca gcccccaggg aggggactgg
      181 agtggattgg gtatatctat ggtagtcgtg ggggcgccac ctacaacccg tccctcaaga
      241 atcgagtcac catctcaaaa gacacgtcca agaaccagtt gtccctgaag ctgaactctg
      301 tgaccgccgc ggacacggcc gtatattatt gtgcgagaca gtgttgttac tatgatgact
      361 ttttagacta ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006483             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19701:11385
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006483
VERSION     KCXD01006483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19701:11385"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64965.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          121 c          146 g          129 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttc agtgcctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 atgccaagaa ctccttgtat cttcaaatga acaacctgag agctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc actacagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006484             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:23665:11702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006484
VERSION     KCXD01006484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:23665:11702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64966.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          119 a          142 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atccactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccct
      481 ttcctcagcc
//
LOCUS       KCXD01006485             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:26976:10344
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006485
VERSION     KCXD01006485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:26976:10344"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..469
     V_segment       106..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64967.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       411..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           96 a          133 c          137 g          105 t
ORIGIN      
        1 acatggggaa aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctccg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcta tcagcagtag ttactgcagc tggatccgcc agaccccagg gaagggactg
      241 gagtggattg gctatatata tgggagtgat agtagtacca actacaaccc ctccctcaag
      301 agtcgagtca ccctgtcagt ggacacgtcc aagaaccagt gctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtgtatttt tgtgcgagtt cgggtataga agtggttgcg
      421 tacagcattg actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006486             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18552:18696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006486
VERSION     KCXD01006486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18552:18696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64968.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          138 c          139 g          102 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagg tacaggcgcc
      121 cactctgagg tccagctggt gcagtcgggg gctgaggtga agaagcctgg ggcctcagtg
      181 aagttctcct gtaaggtttc cggatacacc ttcaccgaat tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctgtttt tggtgaaata
      301 atgaattcag agaagttcca gggcagagtc gccttgaccg aggacacgtc tacagacaca
      361 gcctacatgg agttgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaca
      421 tcatccagcg gcacctggct atattggtac ttcgatgtct ggggccctgg caccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01006487             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17509:13018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006487
VERSION     KCXD01006487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17509:13018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64969.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          110 c          146 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaattgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gaggctctcc tgtgcagcct ctggattcac cttcacaaat tatggcttgc
      241 actgggtccg ccaggctcca gtgaaggggc tggagtgggt tgcagttata tcgtatgatg
      301 aaaatgtgaa attctacgca gactctgtaa aggaccgatt caccatctcc agagacaatt
      361 ccaagaagat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006488             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10879:19025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006488
VERSION     KCXD01006488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10879:19025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    82..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        82..436
     V_segment       82..377
                     /gene="IGHV2-173"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64970.1"
                     /translation="CARRLWGRFDSW"
     D_segment       384..390
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..436
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           93 a          134 c          110 g          101 t
ORIGIN      
        1 acatggggac tcctgtgccc caccatggac acgctttgct ccacgctcct gctgctgacc
       61 gtcccgtcct gggtcttgtc ccaggtgacc ttgaaggagt ctggtcctac gctggtgaaa
      121 cccacacaga ccctcacgct gacctgtacc ttctctgggt tctcaatcag ttctactgat
      181 acgggtgtga gctggatccg tcagccccca gggaaggccc tggaatggct tgcaaccgtt
      241 tattgggata atgataagtt cttcggcaca tctctgaaga acagactcac catctccaag
      301 gacacctcca aaaaccaggt ggttctcaca atgaccaaca tggaccctgt ggacacagcc
      361 acatattact gtgcacgacg actctgggga aggtttgact cctggggcca gggagtcctg
      421 gtcagtgtct cctcagcc
//
LOCUS       KCXD01006489             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11256:5587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006489
VERSION     KCXD01006489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11256:5587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64971.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       416..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          136 c          139 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccata cactggatgc gacaggcccc
      241 tggaaaaggg cttgagtggg tggggggtgt tgatcctgaa tatggtgaaa tgacacacgt
      301 agagaaattc cagggcagag tcaccttgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtgtat ttctgtgcag ccggatatag
      421 tggcagctgg aactcctggt acttcgattt ctggggtcct ggcaccgcaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01006490             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20583:15182
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006490
VERSION     KCXD01006490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20583:15182"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..339
     V_segment       8..251
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <243..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64972.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       260..282
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..339
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           74 a           98 c           85 g           84 t
ORIGIN      
        1 acatggggtc cctcacatgc gctgtctctg gtggctctat cagcagtact aaatggtgga
       61 actggatccg ccagccccca gggaaagggc tcgagtggat tgggtatatc agtggtagta
      121 gtggtaacac ctactacaac ccctccctca agagtcgagt caccatttca acagacacgt
      181 ccaacaacca gttctccctg aagctgagct ctgtgaccgc cgcggacacg gccttttatt
      241 attgtgcgag atcccaatca tattgtagtg ggctttactg cttcggctac tactactttg
      301 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006491             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19390:14904
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006491
VERSION     KCXD01006491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19390:14904"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64973.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          140 c          135 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcgac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gatgtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ttggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006492             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17993:4671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006492
VERSION     KCXD01006492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17993:4671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64974.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          116 c          154 g          120 t
ORIGIN      
        1 acatgggggc gctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgt
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctggc ttcaccttca attcctttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgca
      301 tgatgaaact aagaaatact acgcagactc tgtgaaagac cgattcagca tctccagaga
      361 caattccaag aacatggtct atcttcaaat gaacaacctg agattggagg acacggccgt
      421 ctattactgt gtgagagatg cgtttggtag cgggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006493             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14509:12209
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006493
VERSION     KCXD01006493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14509:12209"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64975.1"
                     /translation="CARDESAWNYPFDYW"
     D_segment       407..416
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           89 a          142 c          132 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg accggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cactcactgg tggagctgga tccgccagcc ccccgggaag ggactggagt
      241 ggattggacg tatctctggt actagtggga ggactgacta caacccctcc ctcgagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cttgaagttg aattctgtga
      361 ccgccgcgga cacggcccta tattactgtg cgagagatga gtccgcctgg aactatccct
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006494             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23027:11541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006494
VERSION     KCXD01006494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23027:11541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64976.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          135 c          129 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaattgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga catgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006495             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5674:10590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006495
VERSION     KCXD01006495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5674:10590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64977.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       441..446
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          115 c          159 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtactttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttacatcg
      301 tctgatgaaa gtaagaaata ctacgcagac tctgtgaagg cccgattcac cgtctccaga
      361 gacaattcca agaacatgtt atatcttcaa acggacaacc tgaaattgga agacacggcc
      421 gtgtattact gcgcgagaga tgtctggggg aggggatttg actattgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006496             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20112:6124
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006496
VERSION     KCXD01006496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20112:6124"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64978.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          137 c          132 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggc
      181 ggctccatca ccaatagcta ctggaactgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg tggcactggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggtt gacctctgtg
      361 accgccgcgg acaccgccgt ttattattgt gcgagatatg aggatgaata cagtgactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006497             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:7959:8308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006497
VERSION     KCXD01006497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:7959:8308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64979.1"
                     /translation="CAISSSGSWLFWYFDIW"
     D_segment       424..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          118 a          144 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggccc agctggtgca gtctggggcg gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacatcttc accgaattat cgttccactg ggtgcgccag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgcatttgg tgaaatgata
      301 cacacagaga aattccaggg cagaatcacc atgaccgagg acacgtccac agacacagcc
      361 tacatggaac taagcagcct gagatctgag gacacggccg tgtatttctg tgcgatatca
      421 tccagcggca gctggctatt ctggtatttc gacatctggg gccctggcac tccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006498             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12753:23687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006498
VERSION     KCXD01006498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12753:23687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..496
     V_segment       116..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64980.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       416..429
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>502
                     /gene="IGHG"
BASE COUNT          111 a          135 c          146 g          110 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc agtcccaggt
      121 ccacctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga agctctcctg
      181 caaggcttct ggatacacct tcagcatctc tgccatcagt tgggtgcgac aggcccctgg
      241 acaagggctt gggtggatgg gagggatcat ccctcttgtt ggtatgacaa actacgaaca
      301 gaagttccag ggcagagtca cgattaccgc ggacacgtcc acgaatacag tcttcatgga
      361 actgagcagc ctgagatttg aggacacggc cgtctactat tgtgcgacag gggtatatta
      421 ccaggatgaa aacggttatt tttatgtcgg cggtgacttt gactactggg gccagggagt
      481 cctggtcacc gtctccccag cc
//
LOCUS       KCXD01006499             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:19795:13084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006499
VERSION     KCXD01006499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:19795:13084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64981.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       436..441
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          103 a          124 c          154 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacacacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cattgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtcccta agactctcct gtgcagcatc cggattcagc ttcagtgacc actgcatgca
      241 ctgcgtccgc caggcttcag ggaaggggct ggagtgggtc tcaggtatta cttatactgg
      301 tgttaccaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgtggga ggaaggcggc acgtggacct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006500             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13651:18783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006500
VERSION     KCXD01006500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13651:18783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..488
     V_segment       137..423
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64982.1"
                     /translation="CTGGAYANLDYW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          105 a          128 c          154 g          103 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctttttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtcgct actggatgaa
      241 ctgggtccgc caggctccag gaaagggact ggagtgggtc tcagctatta atagtgatgg
      301 ggagaacaca tactacgcag actccgtgaa gggccgattc tccatctcca gagacaactc
      361 aaagaacacg ctctccctgc aaatgaacag cctgagaccg gaggacacgg ccgtgtatta
      421 ctgcacgggc ggggcatacg ctaacctcga ctactggggc cagggagtcc tggtcaccgt
      481 ctcgtcagcc
//
LOCUS       KCXD01006501             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15113:17070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006501
VERSION     KCXD01006501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15113:17070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    18..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        18..378
     V_segment       18..311
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <303..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64983.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       324..329
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       341..378
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           80 a          112 c          105 g           83 t
ORIGIN      
        1 acatgggggt cctgtcccag gtccagttgc aggagtcggg cccaggactg gtgaagcctt
       61 cggagaccct gtccctcacc tgcgctgtct ctggtgactc catcagcggt tactactgga
      121 actggatccg ccaaccacca gggaaggggc tggagtggat tgggtttatc gctggtagta
      181 gtgggaccac caactacaac ccctccctca agagtcgagt caccatctca acagacacgt
      241 ccaagaacca gttctccctg aacctgaact ctgtgaccgc cgcggacacg gccatgtatt
      301 actgtgcgag aaatagattt atgggtatta gagttcttgc ctactggggc cagggagtcc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006502             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:12353:3503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006502
VERSION     KCXD01006502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:12353:3503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..457
     V_segment       106..395
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64984.1"
                     /translation="CASNSITSGPDYW"
     D_segment       401..407
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           91 a          140 c          124 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgag gcacctgtgg
       61 ttcttcctcc tcctggcggc agctcccaga tgggtcctgt cccgcctgca gctgcaggcg
      121 tcgggcccag gactggtgaa gccttcggag accctgtctc tcacctgcgc tgtctctggt
      181 gcctctatca gcggtaacta ctggagctgg atccgccagg ccccagggaa gggactggag
      241 tggattggat atatctatgg tagtgatatt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagttct ccctgaacct ggcctctgtg
      361 accgccgcgg acacggccat ctatttctgt gccagtaaca gtataacatc tggtccagac
      421 tattggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006503             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:16911:10937
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006503
VERSION     KCXD01006503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:16911:10937"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64985.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       439..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          133 c          148 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctggcttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gcacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctgaaa tgggtctcat ctattagtag
      301 tggtggtctc acatactacg cagactccgt gaagggccga tttgccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagcctgagc gctgaggaca cggccgtata
      421 ttactgtgcg aaaggaggta gcagctcttt ctattggtac ttcgatatct ggggccctgg
      481 caccccagtg accatctcct cagcc
//
LOCUS       KCXD01006504             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17678:8266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006504
VERSION     KCXD01006504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17678:8266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64986.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          143 c          135 g           96 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggtcca actgatacag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acgcagaaag attccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagtctg agatctgaag acacggccgt gtattactgt gcgacatcac
      421 ccagcggcac ctggctatat tggtacttcg atttctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01006505             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14938:11377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006505
VERSION     KCXD01006505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14938:11377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..298
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..298
     V_segment       9..221
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <214..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64987.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       239..247
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       254..298
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        299..>300
                     /gene="IGHG"
BASE COUNT           74 a           69 c           82 g           75 t
ORIGIN      
        1 acatggggat tcaccttcag tagctttgac atgcactggg ttcgccaggc tccagggaag
       61 ggtctggact gggtatcagg tattaacatt ggcggtgaca catactaccc agactctgtg
      121 aagggtcgat tcactatgtc cagagacaat gccaagaact ccgtgtatct tcaaatgaac
      181 agcctgagag ttgaggacac tgctgtgtat ttttgtgcaa gggggataga taactaccac
      241 tatagtgata cggactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006506             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23853:17071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006506
VERSION     KCXD01006506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23853:17071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64988.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          121 a          139 c          135 g           94 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagcgacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatattg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01006507             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16627:20422
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006507
VERSION     KCXD01006507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16627:20422"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64989.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          142 c          144 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctggggcc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatac
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt gtatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006508             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13421:18461
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006508
VERSION     KCXD01006508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13421:18461"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64990.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          138 c          138 g           97 t
ORIGIN      
        1 acatggggat ccaacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatggtgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctatagac acagcctaca tggagttgag
      361 cagcctgaga tctgaggaca cggccgtgta ttattgcgcg attggcccta gcggcaactg
      421 gaacggctgg tccttcgata tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006509             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8354:4048
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006509
VERSION     KCXD01006509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8354:4048"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64991.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       419..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          108 a          140 c          147 g          107 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 tcaggtccag ctggtgcagt ccggggctga gatggagaag cctggggcct cagtgaagct
      181 ctcctgtaag gcttctggat acagcttcag catctatgtc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg catcttccct cttgttggta caacaaacta
      301 cgcacagaag ttccagggca gagtcacgat taccgcggac acggccacaa gcacagccta
      361 catggacctg agcagcctgg gatctgggga cacggccgtg tattattgtg cgagaggtta
      421 ctgtactggc aatggttgta accttacttt caaccggctc gatgtctggg gcccgggagt
      481 cccggtcacc gtctcctcag cc
//
LOCUS       KCXD01006510             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:10476:8892
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006510
VERSION     KCXD01006510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:10476:8892"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..479
     V_segment       122..415
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64992.1"
                     /translation="CARGRIHLQFMDSW"
     D_segment       428..435
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          112 a          133 c          138 g           98 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagcgcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgtaag gcttctggat acaccttcaa catgtttgcc atcaattggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gaacatccct cttgttgata taacaaagta
      301 cgcacagaag ttccaggaca gagtcacatt taccgcggac acgtccacta gcacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg cgagagggag
      421 gattcaccta cagttcatgg actcctgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01006511             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11214:4879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006511
VERSION     KCXD01006511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11214:4879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64993.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          114 c          151 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtaca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag aacatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006512             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15309:16648
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006512
VERSION     KCXD01006512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15309:16648"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64994.1"
                     /translation="CPRGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          114 c          155 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcgt
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaga tgaacaacct gaaattggag gacacggccg
      421 tatattactg tccgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006513             284 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:20539:3087
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006513
VERSION     KCXD01006513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 284)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 284)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:20539:3087"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..282
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..282
     V_segment       9..209
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <201..>251
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64995.1"
                     /translation="CVRDSSWYNWDQDFDYW"
     D_segment       220..230
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       238..282
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        283..>284
                     /gene="IGHG"
BASE COUNT           65 a           75 c           84 g           60 t
ORIGIN      
        1 acatggggaa ctactggagt tggatccgcc agcccccagg gaagggactg gagtggattg
       61 gacgtaccac tgatagtggt gggagcaccg actacaaccc ctccctcaag agtcgagtca
      121 ccatttcagc agacacgtcc aagaaccagt tctccctgga gttgaggtct gtgaccgccg
      181 cggacacggc cgtgtattat tgtgtgagag atagtagttg gtataactgg gaccaagact
      241 ttgactattg gggccaggga ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006514             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20191:22072
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006514
VERSION     KCXD01006514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20191:22072"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64996.1"
                     /translation="CARDVYGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          116 c          154 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgaa actggtggag tctggaggag gcttggttcg
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 cgtccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggtat atcttcaaat gaacaacctg aagttggagg acacggccgt
      421 ctattactgt gcgagagacg tatatggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006515             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14913:11042
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006515
VERSION     KCXD01006515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14913:11042"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..499
     V_segment       144..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64997.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       440..444
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          113 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatatctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtatttct gtgtgagaga tgccttcggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006516             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:14808:15873
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006516
VERSION     KCXD01006516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:14808:15873"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64998.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          118 a          141 c          130 g          100 t
ORIGIN      
        1 acatgggagc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagctc
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaagtaaagg ggcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatggga ggttttggtc ctgtgtatgg tgaaataata
      301 cacacagaga agttccaggg cagagtcact atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01006517             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13459:12611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006517
VERSION     KCXD01006517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13459:12611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..474
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX64999.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       402..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..474
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           95 a          140 c          137 g          104 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccttcag cggttactac tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattggata tatcagtgct agtagtggga ccaccgacta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaagagac acgtccaaga acctcttctc cctgaacctg agctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagagaa atactatagt ggtagttata
      421 aacacaactg gttcgatgtc tggggcccgg gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01006518             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7761:9023
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006518
VERSION     KCXD01006518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7761:9023"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..432
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65000.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       443..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          121 a          115 c          152 g          126 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gatttccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgcagc ctctggattc accttcaatg agtatgccat
      241 gagctgggtc cgccaggctt ctgggaaagg actggagtgg attggctata ttagaagcaa
      301 atataacgat tacgcgacag aatatgccgc atcggtgaat ggcagattca ccatctccag
      361 agatgattca aagaacacac tatatctgca gatgagcagc ctgaaaaccg aggagacggc
      421 cgtgtattac tgcacccgtc tctatagtgg gaactataga attatgatgt ttgactactg
      481 gggccaggga gtcctggtca gtgtctcctc agcc
//
LOCUS       KCXD01006519             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7520:12130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006519
VERSION     KCXD01006519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7520:12130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..495
     V_segment       137..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65001.1"
                     /translation="CARARGVIITYFDYW"
     D_segment       437..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          102 a          122 c          159 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgac
      241 ctgggtccgc caggctccag ggaaggggct ggaatggatc tcaggtatta gcagtggtgg
      301 ggatagcaca tcctatgcag actccgtgaa gggcagattc accatctccc gagaggacgc
      361 caagaacaca ctgtatcttc agatggacag tctgagagtt gaggacacgg ctgtctatta
      421 ctgtgcgagg gcgcgcgggg tgattattac atactttgac tactggggcc agggagtcct
      481 ggccaccgtc tcctcggcc
//
LOCUS       KCXD01006520             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9282:8682
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006520
VERSION     KCXD01006520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9282:8682"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..491
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65002.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       418..432
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          144 c          139 g          102 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaagctt tccggatcca ccttcaccga attatccata cactgggtgc gacaggcccc
      241 tggaaagggg cttgaatgga tgggaggtgt tgctcctctt tatggtgaaa tgatgcacgc
      301 agacaacttc cagggcagag tcaccttgac cgaggacccg tctacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgacgacac ggccgtgtat tactgtgcgc gtgggcctat
      421 tacaattttt ggcgtactta ttacggggct tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006521             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23702:3329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006521
VERSION     KCXD01006521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23702:3329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65003.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          118 c          147 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtggctg acagttatat cgtatgatga
      301 aactaagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacgcgg ccgtgtatta
      421 ctgtgcgaga gattcttacg gtcgaggctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006522             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13204:14039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006522
VERSION     KCXD01006522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13204:14039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65004.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       411..415
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          103 a          113 c          134 g          115 t
ORIGIN      
        1 acatgggcag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgctgctatt ttaagaggtg tccagtgtga ggtccacctg
      121 gtggaatctg gaggaggctt ggttcagcct ggggggtccc tgagactctc ctgtgcagcc
      181 tctggattca ccttcagttc ctttggcatg cactgggtcc gccaggcacc ggggaagggg
      241 ctggagtggg tggcagtttt atcgtctgat ggaactaaca aatactacgc agactctttg
      301 aaagaccgat tcaccatatc cagagacaac tccaagaaca tactatatct tcaactgaac
      361 aacctgaaat tggaggacac ggccgtgtat tactgtgcga gagatgtgta tggctcgggg
      421 cttgactact ggggccaggg agtcctgctc accgtctcct cagcc
//
LOCUS       KCXD01006523             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9117:16833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006523
VERSION     KCXD01006523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9117:16833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65005.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          138 c          133 g          102 t
ORIGIN      
        1 acatgggggg gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcagtggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtaatagt gggaccacct actacaaccc ctccctcaag
      301 agtcgagccg ccatttcaaa agacacgtcc aacaatcaat tctccctgag gttgagttct
      361 ctgaccgccg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006524             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13497:15194
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006524
VERSION     KCXD01006524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13497:15194"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65006.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       404..411
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           82 a          143 c          137 g          101 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc gcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactcct ggagctggat ccgccagccc ccaggcaagg gtctggagtg
      241 gattggacat gtcagtggta gtagtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagcg ccagttctcc ctgaggctga tttctgtgac
      361 cgccgcggac acggccgtct atcattgtgc gagagtccgg ggcgtgacta tctattactt
      421 tgactactgg ggccagggag ccctggtcac cgtcgcctca gcc
//
LOCUS       KCXD01006525             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15717:7130
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006525
VERSION     KCXD01006525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15717:7130"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65007.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          143 c          136 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccatt
      121 ctgaggtcca gctggtgcaa tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tttatatggt gaaatgatac
      301 acacagaaca gttccagggc agagtcaccc tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtattactgt gcgagtggcc
      421 ctagcggcag ctggaacgac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01006526             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:25266:15751
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006526
VERSION     KCXD01006526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:25266:15751"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65008.1"
                     /translation="CAGGAYANLDYW"
     D_segment       435..439
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          124 c          154 g          111 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca aatggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagatactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctcttaatta
      301 tgatggggat agtacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcaaag aacacgctct ccctacaaat gcacagcctg agagaggatg acacggccgt
      421 atatttctgt gcgggtgggg cgtacgctaa cctcgactat tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006527             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15024:12434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006527
VERSION     KCXD01006527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15024:12434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65009.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       444..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          119 c          151 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tatgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatggt gtatcttcaa atgaacaacc tgacatttga ggacgcggcc
      421 gtgtattact gtgcgagaga ttcttacggt cgaggctttg attcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006528             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22655:4347
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006528
VERSION     KCXD01006528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22655:4347"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65010.1"
                     /translation="CARDEGDVSGYRFGYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          114 c          160 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtggc gtctggagga ggcttggttc
      181 agcctggggg gtccctgaaa ctctcctgtg cagcctctga attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ttgatggaag taagaaatac tacgcagact ctatgaagga ccgattcacc atctctagag
      361 acaattccaa gaacatgcta tatcttcaag tgaacaacct gagattggag gacacggcca
      421 tgtattactg tgcgagggat gagggggacg ttagcgggta ccgatttggc tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006529             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:8443:4590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006529
VERSION     KCXD01006529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:8443:4590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65011.1"
                     /translation="CARHLYSWKGKWIDVW"
     D_segment       408..414
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          135 c          134 g          104 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacaga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gggctggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agagagtact attggagctg gatccgccag gccccaggga agggactgga
      241 gtggattggc tacatctatg gtaacattgg gagcaccagc tataacccgt ccctccagag
      301 tcgagtcacc gtttcaatag acacgtccaa gaatcacttc tccctgaagt tgacgtctgt
      361 gaccgccgcg gacacggccg tatatcactg tgcgagacat ctctattcct ggaaagggaa
      421 gtggatcgat gtctggggcc cgggagtcct gatcaccgtc tcctcagcc
//
LOCUS       KCXD01006530             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:18573:13388
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006530
VERSION     KCXD01006530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:18573:13388"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..502
     V_segment       122..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65012.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       422..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>508
                     /gene="IGHG"
BASE COUNT          113 a          138 c          147 g          110 t
ORIGIN      
        1 acatggggga cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccac ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag acttctggat acaccttcag catctctgcc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgggt ggatgggagg gatcatccct cttgttggtg tgacaaacta
      301 cgaacagaag ttccagggca gagtcacgat taccgcggac acgtccacga atacagtctt
      361 catggaactg agcagcctga gatctgagga cacggccgtc tactattgtg cgacaggggt
      421 atattaccag gatgaatacg gttattttta tgtcggcggt gactttgact actggggcca
      481 gggagtcctg gtcaccgtct ccccagcc
//
LOCUS       KCXD01006531             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20400:9074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006531
VERSION     KCXD01006531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20400:9074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65013.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          109 c          154 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcaggagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atattacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006532             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:24104:2667
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006532
VERSION     KCXD01006532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:24104:2667"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..327
     V_segment       1..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65014.1"
                     /translation="CARVDCSGGVCFFDYW"
     D_segment       264..282
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       285..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           75 a           78 c           93 g           83 t
ORIGIN      
        1 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtggctatg
       61 gcatgaactg ggtccgccag gctccaggga agggactgga ttgggtgtca attatatcgt
      121 ttgatggaac taagaaatac tacgcagact ctgtgaagga ccggttcacc atctccagag
      181 acaattccaa gaacatacta tatcttcaaa tgaacagcct gaaattggag gacacggccg
      241 tgtattactg tgcgagagtg gactgtagtg gtggtgtctg cttttttgac tactggggcc
      301 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006533             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21530:10680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006533
VERSION     KCXD01006533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21530:10680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65015.1"
                     /translation="CASVTFGTSVWSSLFYGLDSW"
     D_segment       435..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          139 c          146 g          100 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggaga caccttcagt gaaatgtcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatgggga aataatacac
      301 gcagataact tccagggcag agtcaccatg accgaggaca cgtctataga cacagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtat attactgtgc gagcgtgaca
      421 tttgggacca gcgtctggtc cagcctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcagcg tctcctcagc c
//
LOCUS       KCXD01006534             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18152:17320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006534
VERSION     KCXD01006534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18152:17320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65016.1"
                     /translation="CATGRIGSSAWSNLFTGLDSW"
     D_segment       430..443
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          116 a          147 c          146 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtttggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgt aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctggg aaagggcttg agtggatggg agttgttgat cctgccaatg gtgaagaaat
      301 acacgcagag aagttccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggac ttgaccagtc tcagatctga ggacacggcc atctattact gtgcgacagg
      421 gaggatcggt agcagcgcct ggtccaacct cttcaccggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006535             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8465:15348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006535
VERSION     KCXD01006535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8465:15348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65017.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       406..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          105 a          143 c          135 g           92 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attgtccatg cactgggtgc gacaggcccc
      241 aggaagaggc cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgacgttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag
      361 cctgagatct gaggacacgg ccgtatatta ctgtgcgatc ggccctagcg gcagttggaa
      421 cgcctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01006536             296 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21304:12034
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006536
VERSION     KCXD01006536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 296)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 296)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21304:12034"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..294
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..294
     V_segment       8..232
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <225..>263
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65018.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       239..250
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       251..294
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        295..>296
                     /gene="IGHG"
BASE COUNT           61 a           85 c           85 g           65 t
ORIGIN      
        1 acatgggtgt ctctggtggc tctatcagta tttactactg gaattggatc cgccaggccc
       61 cagggaaggg actggactgg attggacata tctatggtag cggtggtagc accaactaca
      121 acccctccct caagagtcga gtcaccctgt cagtagacac gtccaagaac cagttctccc
      181 tgaacctgag gtctgtgacc gccgcggaca cggccgtata ttactgtgcg agcggtcggc
      241 ggcagctgga ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006537             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7035:6377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006537
VERSION     KCXD01006537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7035:6377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65019.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          115 c          151 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 caaccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcttgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 aatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga
      361 gacaattcca tgaacatgct atttcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006538             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19988:11963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006538
VERSION     KCXD01006538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19988:11963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65020.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       430..442
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          142 c          149 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtaaag
      181 gtctcctgcc aggtttccgg atacaccttc agtgaaatgt ccatgcactg ggtgcgacag
      241 gcccctgaaa aagggcttga gtggatggga tgtgttgctc ctggaaatgg tgaaataata
      301 cacgcagaga acttccaggg cagagtcacc atggccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagcct gagatctgac gacacggccg tatattactg tgcgacaggg
      421 aggttcggga gcagcgtctg gtccagcctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006539             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4078:19447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006539
VERSION     KCXD01006539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4078:19447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65021.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       441..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          117 c          147 g          117 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg ttcggcctgg
      181 ggggtccctg agactctcct gttcagcctc tggattcacc ttcagtaatt ttggcatcca
      241 ctgggtccgc caggctccag ggaagggcct ggagtgggtg gcagttacat cgtctgatga
      301 aagtaagaaa tactatgcag actctgtgaa ggaccgattc accctctcca gagacaattc
      361 caagaatata ctatatcttc aaatgaacaa cctgaagttg gaggacacgg ccgtctatta
      421 ctgtgcgaga gacgcatatg gcagcggctg tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006540             335 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10166:13868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006540
VERSION     KCXD01006540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 335)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 335)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10166:13868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..333
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..333
     V_segment       8..272
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <264..>302
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65022.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       283..287
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..333
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        334..>335
                     /gene="IGHG"
BASE COUNT           71 a          102 c           90 g           72 t
ORIGIN      
        1 acatgggggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct ggtggcgcca
       61 tcagcagtgg tttctactgg acctggatcc gccaaccccc aggaaagggg ctggagtgga
      121 ttgggtgtat cggaggtaat agtggtacca cctactacaa cccctccctc aagagtcgag
      181 ccaccatttc aaaagacacg tccaacaatc aactctccct gaagctgagt tctgtgaccg
      241 ccgcggacac ggccgtgtat tactgtgcga gagatgaaga cccctccatt tttgactact
      301 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006541             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:25393:14679
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006541
VERSION     KCXD01006541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:25393:14679"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65023.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          140 c          147 g          106 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata cagcttcagc atctatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt gccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggca atggttgtaa ccttactttc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01006542             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15850:14930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006542
VERSION     KCXD01006542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15850:14930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65024.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       439..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          114 c          153 g          118 t
ORIGIN      
        1 acatggggac tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca actggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgcgac tctcgtgtgt agcctctgga ttcaccttca ctacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgaa
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacct tgtccagaga
      361 caataccaag aacatgttat atattcagat gaacaacctg aaattggagg acacggccat
      421 atattactgt gtgagagatg actacggtag cggcctcggg tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006543             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6906:12828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006543
VERSION     KCXD01006543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6906:12828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..506
     V_segment       146..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65025.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       439..454
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..506
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          106 a          126 c          160 g          116 t
ORIGIN      
        1 acatgggggc agctctggga gaggagccca gcactggaag tccacagtgt tccattcggt
       61 gatcagcact gaacacagag gactcaccat ggagtctggg ctgagctggg ttttccttgt
      121 tgctatttta agaggtgtcc agtgtgaggt gcaggtggtg gagtctgggg gcggcttggc
      181 aaagcctggg ggatccctga gactctcctg tgcagcctct ggattcacct tcagtaccta
      241 tgctatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtct cagccattag
      301 tgttggtggt agtacatact acgcagactc cgtgaggggc cgattcacca tctccagaga
      361 caactcagag aacacgctct ccctacaaat gaacagcctg agagctgagg acacggccgt
      421 gtattactgt gcgaaagggg atacagctac agtttattac ggtttggatt cctggggcca
      481 aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01006544             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13749:8866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006544
VERSION     KCXD01006544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13749:8866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65026.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          135 c          134 g          106 t
ORIGIN      
        1 acatggggat ggtctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcac tgtctctggt
      181 ggctccgtca gcaatagtta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg gggtactggg agcgccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acaccgcctt gtattattgt gcgagatatg aggatgaata cagtgactac
      421 tactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006545             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19922:3125
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006545
VERSION     KCXD01006545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19922:3125"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65027.1"
                     /translation="CARGYCSGSHCSSGFDYW"
     D_segment       419..428
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          118 a          138 c          144 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aggtgttgat cctctatatg gtgaaaaaag
      301 acacgcagag aagttccagg gcagagtctc catgaccgag gacacgtcta caaacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtactatt gtgcgagagg
      421 atattgtagc ggtagtcact gctcgtccgg atttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006546             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15774:8684
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006546
VERSION     KCXD01006546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15774:8684"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65028.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       452..465
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          114 a          115 c          156 g          125 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgagata cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tttgatggaa gtaagaaata ctacgcagac tctatgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct agatcttcaa atgagcaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaat ggattgtact ggtggtgtct gctactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006547             368 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15349:13246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006547
VERSION     KCXD01006547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 368)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 368)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15349:13246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..366
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..366
     V_segment       4..286
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <285..>335
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65029.1"
                     /translation="CTSHYSGSYYLDYFDSW"
     D_segment       295..315
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       319..366
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        367..>368
                     /gene="IGHG"
BASE COUNT           85 a           88 c          105 g           90 t
ORIGIN      
        1 acatggggga gtctggggga ggcttggtcc agcctggcgg gtccctgaga ctctcctgtg
       61 ctgcctctgg atttagtttc ggagactttg ccatgagttg ggtccgccag gcttctggga
      121 aaggactgga gtgggttggc tatattagaa gcgtacatag gaattacgcg acagaatacg
      181 ccgcgtcggt aaaaggcaga tttaccatct ccagagatga ttcaaagaac acgctatatt
      241 tacaaatgag cagcctgaaa accgaggaca cggccgtcta tttctgcacc agccactata
      301 gtggtagtta ttacttagac tactttgact cctggggcca gggagtcctg gtcaccgtct
      361 cctcagcc
//
LOCUS       KCXD01006548             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8568:16225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006548
VERSION     KCXD01006548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8568:16225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65030.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       412..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          138 c          128 g          111 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtagct tttggatctg gatccgccag cccccaggga agggcctgga
      241 gtggataggg tctatctatg gtgctactgg gagcaccttt tacgacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccaattt tccctgaagc tggactctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat agcgatactg atagttatta
      421 ctactttgac tactggggcc agggagtccg ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006549             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:25016:5646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006549
VERSION     KCXD01006549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:25016:5646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65031.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          115 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttcttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgta
      301 tgatgaaagt aagaaatact acgcagactc tctgaaggac cgattcacca tttccagaga
      361 caattccaag aacacggtat atcttcaaat gaacaacctg caattggagg acacggccgt
      421 gtattactgt gcgagagatg ataatggggt gcttatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006550             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16541:21143
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006550
VERSION     KCXD01006550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16541:21143"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..486
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65032.1"
                     /translation="CARARYYHDSGYHWYFDIW"
     D_segment       414..433
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          114 a          145 c          130 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgacga agcctggggc ctcagtgaag ctctcctgcc
      181 aggcttctgg ctacaccttc aacatctacg ccatcagctg ggtgcgacag gcccccggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tataacaaac tacgcacaaa
      301 agttccaggg cagagtcacg gttaccgcgg acacgtccat aactacagcc tacatggaac
      361 tgaacagcct aagatctgag gacacggcca tatattactg tgcgagagcg cgatattacc
      421 atgatagtgg ttaccactgg tacttcgata tctggggccc tggcacccca atcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01006551             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:7797:18961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006551
VERSION     KCXD01006551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:7797:18961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65033.1"
                     /translation="CAREGISASGVDYW"
     D_segment       399..405
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          136 c          144 g          100 t
ORIGIN      
        1 acatggggat gctctctgag ggtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtaca acttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tcgcaatggg aacacctact acaacccctc cctcaagagt
      301 cgagtcacca tttcaccaga cacgtccaaa gaccagttct ccctgaggct gaggtctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagggagg ggatatcagc gtcgggggtc
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006552             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12223:18543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006552
VERSION     KCXD01006552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12223:18543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65034.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          113 a          123 c          147 g          130 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag cttctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aacgccgaga actccttgtt ccttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006553             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:9158:3948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006553
VERSION     KCXD01006553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:9158:3948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..397
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65035.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       413..420
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           99 a          140 c          130 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgaagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggagg
      181 ctctatcagc ggtgtttatg actggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatgtccatg gtaatactgg gaacaccgac tacaacccgt ccctcaagaa
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgacgc tgaggtctgt
      361 gaccgccgcg gacacggccg tatattactg tgcgagacgc ccagaaaaca gttactactt
      421 ctactacttt gactactggg gccacggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006554             389 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10628:14608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006554
VERSION     KCXD01006554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 389)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 389)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10628:14608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    12..387
                     /note="immunoglobulin heavy chain variable region"
     V_region        12..387
     V_segment       12..304
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <303..>356
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65036.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       318..329
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       344..387
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        388..>389
                     /gene="IGHG"
BASE COUNT           92 a           96 c          112 g           89 t
ORIGIN      
        1 acatggggtg tgaggtgcag ctggtggagt ctgggggagg cttggtccag cctggcgggt
       61 ccctgagact ctcctgtgca gcctctggat tcaccttcag tgactttgcc atgagctggg
      121 tccgccaggc ttctgggaaa ggactggagt gggttggcta tattagaacc aaatataaca
      181 attacgcggc agaatacgcc gcatcggtga aaggcaggtt caccatctcc agagatgatt
      241 caaagaacac gatatatctg caaatgagta gcctgaaaac cgaggacacg gccgtgtatt
      301 actgcaccac atggagatat tactatagta ctggttaccc cacctttgac tactggggcc
      361 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006555             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12792:16790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006555
VERSION     KCXD01006555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12792:16790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65037.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          118 c          158 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ttcctgcgca gcctctggat tcagcttcaa ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaatagt
      301 ggtggggaaa gtacgtacta tgcagagtcc gtgaggggca gattcaccat ctccagagag
      361 aacgccaaga acacactatt tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006556             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:3577:7649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006556
VERSION     KCXD01006556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:3577:7649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..443
     V_segment       89..382
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65038.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       393..402
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          105 a          102 c          134 g          104 t
ORIGIN      
        1 acatgggagc acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct
       61 tgttgctatt ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt
      121 ggttcggccg ggggggtccc tgagactctc ctgtgcagtc tctggattca ccttcaatac
      181 ctatggcatg cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat
      241 atcgaatgat gaaactaaga aatactacgc agactctgtg aaggaccgat tcaccatctc
      301 cagagacaat tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac
      361 ggccgtgtat tactgtacga gagacgcatt tggcagcggc tgtgactact ggggccaggg
      421 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006557             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15139:17091
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006557
VERSION     KCXD01006557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15139:17091"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65039.1"
                     /translation="CARVRGVNIHYFDYW"
     D_segment       407..411
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           88 a          138 c          136 g          101 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgccg tctctggtgg
      181 ctccttcaga ggttactact ggacctggat tcgccagccc ccagggaagg ggctggagtg
      241 gattgggttt gtcagtggta gtggtgagag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga tttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaaata tccactactt
      421 tgactactgg ggccagggag ccctggtcac cgtcgcctca gcc
//
LOCUS       KCXD01006558             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9860:18713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006558
VERSION     KCXD01006558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9860:18713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    106..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        106..475
     V_segment       106..399
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65040.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       403..411
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           96 a          136 c          140 g          105 t
ORIGIN      
        1 acatggggga aatgttctct gagagtcacg gacatcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggcagctccc agatgggtcc tgtcccagct gcagctgcag
      121 gagtcgggcc caggactggt gaagcctctg gagaccctgt ccctcacctg cgctgtctct
      181 ggtggctcca tgagcagtca ctactgcagc tggatccgcc agtccccagg gaagggactg
      241 gagtggattg gacggatctc tggtagtggt gggagcaccg actacaaccc ctccctcaag
      301 agtcgagtca ccatctcaac agacacgtcc aagaaggaga tctccctgaa gctgagctct
      361 gtgaccgccg cggacacggc cgtgtattat tgtgcgagag aagactatgg tggtaattat
      421 tattttaacc ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006559             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:10955:15748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006559
VERSION     KCXD01006559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:10955:15748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65041.1"
                     /translation="CARNRFMGVRVLAYW"
     D_segment       400..404
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           98 a          135 c          128 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtccagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcagtg tctctggtga
      181 ctccatcagc ggttactact ggaactggat ccgccaacca ccagggaagg ggctggagtg
      241 gattgggtat atcgctggta gtagtgggac catcgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccaattctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccatct attactgtgc gagaaataga tttatgggtg taagagttct
      421 tgcctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006560             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17111:15646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006560
VERSION     KCXD01006560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17111:15646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65042.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       446..451
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          114 c          151 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagag cacagaggac tcaccatgaa atttgggctg aactgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttaaatcatt
      301 tgatggaact aagatatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aatatgttat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cctacgggag cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006561             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:4735:14790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006561
VERSION     KCXD01006561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:4735:14790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65043.1"
                     /translation="CARDESAINNPFDHW"
     D_segment       411..416
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           92 a          137 c          133 g          102 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtgcaa gaacatgaag tatctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag gcttcagaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag aagtcactgg tggagttgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtggtggca tcagcatcta caagccctcc ctcaagagtc
      301 gagtctccat ttcaacagac acgtccaaga atcagttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagatga gagcgccatt aacaaccctt
      421 ttgaccactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006562             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10196:11954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006562
VERSION     KCXD01006562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10196:11954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65044.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          115 a          140 c          149 g           99 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctgggactg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgaaatgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagag cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggtcaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006563             416 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6869:16114
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006563
VERSION     KCXD01006563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 416)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 416)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6869:16114"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    60..414
                     /note="immunoglobulin heavy chain variable region"
     V_region        60..414
     V_segment       60..339
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <333..>383
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65045.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       350..362
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..414
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        415..>416
                     /gene="IGHG"
BASE COUNT           88 a          115 c          128 g           85 t
ORIGIN      
        1 acatgggctg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
       61 aggtctttct ggtgcagtct ggggctgagg tgaagcagcc tggggcctca gtgaaggtct
      121 cctgcaaggt ttccggatac accctcaccg aagtgtccac tcactgggtg cgacaggccc
      181 ccggaaaagg gcttgagtgg gtgggaagtg ttgatcctgc atatggtgaa atgaagttcc
      241 agggcagagt caccatgacc gaggacacgt ccacagacac agcctacatg gaattgagca
      301 gcctaagatc tgaggacacg gccgtgtatt actgtgcgat tggacctacc ggcaggtgga
      361 acggctggtc cttcgatatc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01006564             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22581:2597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006564
VERSION     KCXD01006564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22581:2597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65046.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           92 a          136 c          129 g          110 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gttcccagat gggtcctgtc ccaggtgcag ctgctggagt
      121 cgggcccggg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cactagttac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta tatctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattattgtg tgagatatga ggatgaatcc attaactacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006565             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:26976:7629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006565
VERSION     KCXD01006565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:26976:7629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65047.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       439..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          116 c          148 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caattggtgg agtctggagg aggcttggtt
      181 caacctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa gtaacaaata ctacacaaac tctgtgaaga gccgattcac cgtctccaga
      361 gacaattccc agaacatact ttatcttcaa atgaacaact tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatcttggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006566             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:7554:7122
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006566
VERSION     KCXD01006566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:7554:7122"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65048.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          113 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcgt
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tgtcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagaggg gaatacagta actctattga ctactggggc cggggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006567             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4999:6084
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006567
VERSION     KCXD01006567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4999:6084"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65049.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       436..446
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          119 a          149 c          142 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccaa cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg acaggggctt gagtggatgg gacttgttga tcctgtaaat ggtgaactaa
      301 tacacgcaga caagttccag ggcagagtca ccatgaccga agacacgtct acagacacag
      361 cctacatgga cttgaccagc ctgacatctg aggacacggc catctactac tgtgcgacag
      421 ggaggatcgg taccagtggc tggtccaacc tcttcaatgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006568             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:5620:7409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006568
VERSION     KCXD01006568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:5620:7409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65050.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       401..415
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          141 c          134 g          101 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtacct actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cgtatctctg gtggtggtgg gaacaccgac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaagag acacgtccag gaaccacctc tccctgcagc tgaattatgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagaaca agcggtggct ggtcccccta
      421 ctttgactat tggggccagg gagtcctggt caccgtttcc tcagcc
//
LOCUS       KCXD01006569             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:26011:12642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006569
VERSION     KCXD01006569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:26011:12642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65051.1"
                     /translation="CTTHGGYTGIWNSLYYGFDSW"
     D_segment       436..443
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          121 a          143 c          139 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ttggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgtaaa gtttccggat acacgttcac cgatttatcc attcactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggagg tgttaatcct gaacatggtg aagtaataca
      301 cgcagacagc ttccagggca gagtcgccat gagcgaggac acgtctacag acacagccta
      361 catggagctg aacagcctga catctgagga cacggccgtg tattactgta cgacccacgg
      421 agggtataca ggcatctgga actccctata ctacggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006570             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:19875:6053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006570
VERSION     KCXD01006570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:19875:6053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..444
     V_segment       90..382
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65052.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       383..389
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..444
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT          103 a          100 c          134 g          109 t
ORIGIN      
        1 acatggggag cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc
       61 ttattgctat tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct
      121 tggttcagcc tggggggtcc ctgagactct cctgtacagc ctctggattc accttcagta
      181 gctatggctt gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtgacagtta
      241 tatcgtctga tgaagatagg aaatactacg cagactctct gaaggaccga ttcaccattt
      301 ccagagacaa ttccaagaac acgctatatc ttcaaatgaa caacctgaaa ttggaggaca
      361 cggccgtgta ttactgtgcg agggatgata atggggtgct tatcgacttc tggggccagg
      421 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006571             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:21381:10463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006571
VERSION     KCXD01006571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:21381:10463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65053.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          111 c          156 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gaagcctctg gattcacctt caggagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgtaa gtaagaaata ttacgcagac gctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgggagaga tgataatggg gtgcttatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006572             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:20212:9369
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006572
VERSION     KCXD01006572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:20212:9369"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65054.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       448..454
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..521
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          117 a          126 c          159 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagcact gaacacaaga gactcaccat ggagtttgca ctgagctggg ttttcgttgt
      121 tgctacttta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcaggctct ggattcacct tcagtgacta
      241 tgccatgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaaatct tacaattacg cgacagaata cgccgcatcg gtgaaaggca ggttcaccat
      361 ctccagagat gattcaaagt acacgctaca tctgcaaatg agcagcctga aaaccgagga
      421 cacggccgtg tattactgtg ctagagggga tataccggct atagaggcct actacggttt
      481 ggattcctgg ggccaagggg tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006573             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14828:7175
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006573
VERSION     KCXD01006573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14828:7175"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65055.1"
                     /translation="CARVDCSGGVCYFDYW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          118 a          116 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtg ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtggg gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagccatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca attatatcgt
      301 atgatggaaa tgagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa taaacaacct gaaattggag gacacggcca
      421 tgtattactg tgcgagagta gactgtagtg gtggtgtctg ctactttgac tattggggcc
      481 agggagtcct cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006574             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:15327:14945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006574
VERSION     KCXD01006574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:15327:14945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65056.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       432..438
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          112 c          149 g          119 t
ORIGIN      
        1 acatgggggg ggagaggaac ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tattgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtacagcc tctggattca ccttcagtag ctatggctta
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tgacagttat atcgtctgat
      301 gaaagtagga aatactacgc agactctctg aaggaccgat tcaccatttc cagagacaat
      361 tccaagaaca cgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tattgtgcga gggatgataa tggggtgctt atcgacttct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006575             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20460:11199
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006575
VERSION     KCXD01006575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20460:11199"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65057.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          113 c          153 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcga
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaggatgcta tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccat ctcctcagcc
//
LOCUS       KCXD01006576             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:14717:5189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006576
VERSION     KCXD01006576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:14717:5189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65058.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       446..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          115 c          150 g          122 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgcg
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 ccggaggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tttctatggc
      241 ttgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt aatttcgaat
      301 gatgaaaata acaaatacta cgcagactct gtgaaggacc gattcaccat ttctagagac
      361 aattccatga acatgctatt tcttcaaatg aacaacctga acttggacga cacggccgtc
      421 tattactgtg tgagagatga tttaggcagc ggcttagggt cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006577             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22355:18329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006577
VERSION     KCXD01006577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22355:18329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65059.1"
                     /translation="CARVVGGSAGYFDYW"
     D_segment       439..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          102 a          120 c          160 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcgacttgg caaagcctgg
      181 ggggtccctg agactctcct gcgctgcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcgggtattg acagtggtgg
      301 gggtaccaca tactatgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 cgagaacaca ctgtatcttc aaatggacag cctgacagct gaggacacgg ctgtctatta
      421 ctgtgcgaga gtcgtgggtg gtagtgctgg atactttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006578             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19073:8394
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006578
VERSION     KCXD01006578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19073:8394"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65060.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       426..432
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          122 a          138 c          134 g           95 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagg tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggata catcttaacc gaattatcca tacactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaagt gttgatcctc aatatggtga aatgatagac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gtagtctgag atctgaggac acggccgtgt attactgtgc gacatcatcc
      421 agcggcacct ggctatactg gtacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01006579             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:8378:10160
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006579
VERSION     KCXD01006579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:8378:10160"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65061.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          122 a          143 c          142 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctggga cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 acacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 cttcatggag ttgagcagcc tgagatctga ggacacggcc gtatatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaacct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01006580             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13550:9930
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006580
VERSION     KCXD01006580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13550:9930"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65062.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          119 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006581             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13727:11029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006581
VERSION     KCXD01006581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13727:11029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65063.1"
                     /translation="CASVSSGNYYFLHFEYW"
     D_segment       445..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          115 a          120 c          149 g          130 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattcccagg cgtctccact tggtgatcag
       61 cactgaacac aagagactca ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgagactct cctgtgtagc ctctggattc ggcttcagtg actatgtcat
      241 gagttgggtc cgccagactt ctgggaaagg actggagtgg gttggttata ttagaggcaa
      301 atctaacaat tacgcgacag aatacgcccc atcggtgaaa ggcaggttca ccatctccag
      361 agatgattca aaggacacgc tatatctgca aatgaccagc ctgacaatcg aggacacggc
      421 cgtgtattac tgtgctagcg tctctagtgg taattattac ttcctccact ttgaatactg
      481 gggccaggga gtccaggtca tcgtctcctc agcc
//
LOCUS       KCXD01006582             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12050:12798
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006582
VERSION     KCXD01006582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12050:12798"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65064.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       420..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          118 a          138 c          139 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccagtc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctgggacct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc gttcattggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tattgatcct ctatatggtg aaatgataca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag atacagccta
      361 catggagctg aggagcctga gatctgacga cacggccgtg tattactgtg cgaggtcgga
      421 tagcggcagt tggaacggct ggtacctcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006583             398 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24726:5961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006583
VERSION     KCXD01006583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 398)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 398)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24726:5961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..396
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..396
     V_segment       33..326
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <318..>365
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65065.1"
                     /translation="CARYEADGASYYFDYW"
     D_segment       332..336
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       349..396
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        397..>398
                     /gene="IGHG"
BASE COUNT           74 a          121 c          113 g           90 t
ORIGIN      
        1 acatgggggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag tcgggcccag
       61 gactggtgaa gccctcggag accctgtccc tcacctgcgg tgtctctggt gactccgtcg
      121 tcaatagctt ctggagctgg ttccgcctgc ctctagggaa gggactggag tggattggct
      181 atatctatgg tgcgactggg agcaccacct acaacccctc cctcaagagt cgagccacca
      241 tttccacaga cacgtccaag aatcagtttt ccctgaagct gacctctgtg accgccgcgg
      301 acaccgccgt gtattactgt gcgagatatg aagctgatgg tgcttcttac tactttgact
      361 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006584             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17112:8300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006584
VERSION     KCXD01006584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17112:8300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65066.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          114 c          151 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gcacctttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat attttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagatg tcaggggaac gggatttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006585             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:15760:4410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006585
VERSION     KCXD01006585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:15760:4410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65067.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       442..446
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          113 c          149 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgaactg ggttttcctt gttactattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcaggct ctggattcac cttcagtatt tttggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgaatgatg
      301 gaaataaaaa atactcctca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccgaggccaa tgtatatctt caaatgaata acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agatgcgtat ggctccggct tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006586             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20738:9607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006586
VERSION     KCXD01006586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20738:9607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65068.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       238..246
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       248..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           70 a           68 c           83 g           68 t
ORIGIN      
        1 acatggggga ttcaccttca gtacctctgg catgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggcgg ttatatcgtt tgatgatagt aagaaatact acgcagactc
      121 tgtgaaggac cgattcacca tttccagaga caattccaag aacatgctat atcttcacat
      181 gaacaacctg aaattggaag acacggccgt gtattactgt gtgagagatg cttacggtag
      241 tggctgggac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006587             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14835:18709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006587
VERSION     KCXD01006587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14835:18709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..398
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65069.1"
                     /translation="CARWGDSQSIYYFDFW"
     D_segment       399..403
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           92 a          136 c          133 g          109 t
ORIGIN      
        1 atgggggatg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacatgcgct gtctctggtg
      181 actctattac cagtagtagc tggtggaact ggatccgcca gcccccaggg aaagggctgg
      241 aatggattgg ttatatcagt ggtactagtg ggagcaccga ctatcacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt taccctgacg ttgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagatg gggcgactcc cagtccattt
      421 actactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006588             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14040:7815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006588
VERSION     KCXD01006588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14040:7815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65070.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       417..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          140 c          136 g          106 t
ORIGIN      
        1 acatgggatc acaaaacaac cacatccctc ctctaaagaa gcccctggga gcacagctca
       61 tcaccatgga ctggacctgg aggctcctct ttgtggtggc agcagctgca ggtgtccagt
      121 cccaggtccg cctggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tttcctgcgg ggcttctgga ttcaccctcg acacctatgg tatcaactgg gtgcgacagg
      241 cccctggaca agggcttgag tggatgggag tggtcatccc ccttattggt atcataaact
      301 acgcaaagaa ctctcagggc agactcacaa taaccgcgaa cacgtccaca aatacagcct
      361 atttggaact gagcagtctg agatctgagg acacggccat ctattactgt gcgagagaat
      421 actgtacttc tagttcttgc gccgggttcc ttgactactg gggccaggga gccctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006589             420 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:7708:10548
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006589
VERSION     KCXD01006589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 420)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 420)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:7708:10548"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    52..418
                     /note="immunoglobulin heavy chain variable region"
     V_region        52..418
     V_segment       52..345
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <337..>387
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65071.1"
                     /translation="CARRGYNNADDWYFDFW"
     D_segment       347..355
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..418
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        419..>420
                     /gene="IGHG"
BASE COUNT           89 a          121 c          124 g           86 t
ORIGIN      
        1 acatggggga ggctcctctt tgtggtggca gcagctacag gtgcccagtc ccaggtccaa
       61 ctggtgcagt ccggggctga ggtgaaggag cctggggcct cagtgaagct ctcctgccag
      121 gcttctggat acaccttcgg catctacgcc atcaattggg tgcgacaggc ccctggacaa
      181 gggcttgagt ggatgggagg gatcacccct cttattggct taacaaacta cgcacagaag
      241 ttccagggca gagtcacgct caccgcggac acgtccacaa gtacagtcta catcgagttg
      301 aacagcctga gatctgagga cacggccgtg tatttctgtg cgagacgtgg atacaacaac
      361 gctgacgact ggtacttcga tttctggggc cctggcaccc cgatcaccgt ctcctcagcc
//
LOCUS       KCXD01006590             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9894:17413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006590
VERSION     KCXD01006590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9894:17413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65072.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          112 c          155 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccccgagac tctcctgtgc agtctctgga ttcgccttca gtaactttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag tgacatcgta
      301 tgatggaagt tggaagtact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagggg aatatagtaa ctctattgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006591             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18558:5109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006591
VERSION     KCXD01006591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18558:5109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..495
     V_segment       117..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65073.1"
                     /translation="CASGGFQDENGYYFPDYFDFW"
     D_segment       430..441
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          134 c          150 g          105 t
ORIGIN      
        1 acatggggga caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccaactggt ggagtccggg gctgaggtga agaagcctgg ggcctcagcg aagctctcct
      181 gcaaggccgc tggatacatt ttcagtacct ctgccatcag ttggctgcga caggcccctg
      241 gacaagggct tgagtggatg ggggggatca tgcctcttgt tggtagaaca aactacgcac
      301 agaggttcca gggcagagtc acgattaccg cggacacgtc cacaaggaca gccaacatgg
      361 agctgagcag cctgagatct gaggacacgg ccgtgtatta ttgtgcgagc ggtggtttcc
      421 aggatgagaa cggttactat tttccagact attttgactt ttggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006592             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22079:16507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006592
VERSION     KCXD01006592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22079:16507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..464
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65074.1"
                     /translation="CARYEDDSGYYYFDSW"
     D_segment       408..420
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>468
                     /gene="IGHG"
BASE COUNT           90 a          133 c          129 g          116 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacttgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gttgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcatctgcgc tgtctctggt
      181 gcctccatca ccagtagctt ctggagctgg atccgacagc ccccagggaa gggactggag
      241 tggattggct atatctatgg tagtactggg agtagcagtt ccaatccctc cctcaagagt
      301 cgagtcacca tttcaacgga cacgtccaag aaccagtttt ccctgaaact gagctctgtg
      361 accgccgcgg acaccgcctt ttatttctgt gcgagatatg aagatgatag tggttattac
      421 tactttgact cctggggcca gggagtcctg gtcaccgtct cctcggcc
//
LOCUS       KCXD01006593             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19896:11575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006593
VERSION     KCXD01006593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19896:11575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65075.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          105 a          144 c          133 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gtatatggtg aaatgatgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggagctgag
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg attggcccta gcggcagttg
      421 gaaccactgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006594             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10107:2315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006594
VERSION     KCXD01006594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10107:2315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65076.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          111 a          144 c          136 g           90 t
ORIGIN      
        1 acagggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaactg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01006595             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:3164:8507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006595
VERSION     KCXD01006595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:3164:8507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65077.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          115 a          146 c          125 g           90 t
ORIGIN      
        1 acatgggaca cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 acgtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttctggatac accttaaccg accactacct gcactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggtg ttcatcctga atatggtaaa gcagactaca
      301 cacagaagtt ccaaaacaga gtcaccatca ccgcggacat gtcgacagag acagcctaca
      361 tggagctgag cagcctcaga tctgaggaca cggccgttta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgacttc tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006596             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14644:17826
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006596
VERSION     KCXD01006596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14644:17826"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65078.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       443..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          109 a          121 c          159 g          120 t
ORIGIN      
        1 acatgggggc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag tgtgaggtgc agttggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtctctgaga ctctcctgtg tagcctctgg attcagcttc agaagttacg
      241 aaatgagttg ggtccgccag gctccgggaa aggggctgga gtgggtctca tatattagtc
      301 acactggtga aaccatatac cacgctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgccaa gaattcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattactg tactaggaac cggaatactg taatgattgg gtggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006597             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:8447:14579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006597
VERSION     KCXD01006597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:8447:14579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65079.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       443..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          114 c          153 g          122 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tcgggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gttttggcat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tgtcgtctga
      301 tggaaataac atatactacg cagcctctgt gaaggaccga ttcgccatct ccagagacaa
      361 ttccaagaac atgctatatc ttcaaatgaa caacctgaaa tttgaggaca cggccgtgta
      421 ttactgtgcg agagatgtgt acggtagtgg gttagactac tggggcctgg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006598             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17336:19935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006598
VERSION     KCXD01006598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17336:19935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65080.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       428..434
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          116 a          140 c          131 g           95 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagttggta cagtctgggg ttgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggggttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gttgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 taggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01006599             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:6207:5285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006599
VERSION     KCXD01006599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:6207:5285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..363
     V_segment       8..289
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <282..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65081.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       302..310
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       322..363
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           82 a           80 c          118 g           85 t
ORIGIN      
        1 acatgggggt gcagtctggg gctgaggtga agatgcctgg ggcctcagtg aaggtctcct
       61 gcaaggtttc cggatacagc gtcaccgaat tatccattca ctgggtgcga caggcccctg
      121 gaaaagggct tgagtggatg ggaggtgttg atcctgtaaa aggtgaaata attcacggag
      181 aggggttcca ggacagagtc accatgaccg aggacccgtc tacagacaca gcctacatgg
      241 agttgagcaa cctgagatca gaggacacgg ccgtttatta ttgtgcgagt gggtttagta
      301 tctggttatt ttacgacgtt ctggattcgt ggggccaagg ggtcgtcgtc accgtctcct
      361 cagcc
//
LOCUS       KCXD01006600             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:9074:16272
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006600
VERSION     KCXD01006600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:9074:16272"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65082.1"
                     /translation="CARRGGHGTTTTLYFFDFW"
     D_segment       445..451
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          144 c          141 g          102 t
ORIGIN      
        1 acatggggat cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtggtga agcctggggc ctcagtgaag
      181 ctctcctgca aggcttctgg atacaccctc agcatctctg ccatcagttg ggtacgacag
      241 gcccctggac aagggcttga gtggatggga gagatcttcc ctcttgttgg tatgacaaaa
      301 tacgcacaga acttccaggg cagagtcacg attaccgcgg acacgtccac aagtacagcc
      361 tacatggaac tgagcggcct gagatctgag gacacggccg tatattactg tgcgagaaga
      421 ggtggccacg ggaccaccac cacgttgtac ttctttgact tctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006601             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6603:8739
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006601
VERSION     KCXD01006601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6603:8739"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..520
     V_segment       145..444
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65083.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       447..453
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..520
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          117 a          125 c          157 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattc ccaggcgtct ccacttggtg
       61 atcagcactg aacacaagag actcaccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcaggctctg gattcacctt cagtgactat
      241 gccatgagct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      301 agcaaatctt acaattacgc gacagaatac gccgcatcgg tgaaaggcag gttcaccatc
      361 tccagagatg attcaaagaa caccctacat ctgcaaatga gcagcctgaa aatcgaggac
      421 acggccgtgt attactgtgc tagaggggat ataccggcta tagaggccta ctacggtttg
      481 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006602             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:6897:8452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006602
VERSION     KCXD01006602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:6897:8452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..464
     V_segment       105..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65084.1"
                     /translation="CVRYEGAAAGTWYFDYW"
     D_segment       404..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>469
                     /gene="IGHG"
BASE COUNT           95 a          136 c          135 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caagtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgaccctc acctgcactg tctctggtgg
      181 ctccatcagc agtagcttct ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctatggtg ctactgggac caccagctac aatccccccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaaggtga actctgtgac
      361 cgccgcggac accgccgtat attattgtgt gagatatgag ggggcggcag ctggaacctg
      421 gtactttgac tactggggcc agggagtcca ggtcaccgtc tccttagcc
//
LOCUS       KCXD01006603             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:5058:9319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006603
VERSION     KCXD01006603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:5058:9319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65085.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       432..436
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          104 a          123 c          158 g          115 t
ORIGIN      
        1 acatgggctg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcaa cttcaattac tactacatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtggat ctcaggtatt gacagtggtg
      301 gggatagcac atactatgcg gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caattggaca gcctgagagc tgaggacacg gctgtctatt
      421 actgtgcgag agtggtgggt ggtgccgcag gatacttcga cttctggggc cagggcgccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006604             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19678:16510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006604
VERSION     KCXD01006604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19678:16510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65086.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          121 a          140 c          136 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcgac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ttggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006605             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10141:7141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006605
VERSION     KCXD01006605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10141:7141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65087.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggccg ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctatccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006606             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16557:9500
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006606
VERSION     KCXD01006606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16557:9500"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65088.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          151 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttcttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaag taagaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacggta tatcttcaaa tgaacaacct gcaattggag gacacggccg
      421 tgtattactg tgcgagagat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006607             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8500:15135
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006607
VERSION     KCXD01006607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8500:15135"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65089.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       421..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          138 c          140 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccagt
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctgggacc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc cgttcattgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtattgatcc tctatatggt gaaatgatac
      301 acacagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gatacagcct
      361 acatggagct gaggagcctg agatctgacg acacggccgt gtattactgt gcgaggtcgg
      421 atagcggcag ttggaacggc tggtacctcg atctctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01006608             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10840:9626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006608
VERSION     KCXD01006608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10840:9626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65090.1"
                     /translation="CARGTGAILVYFDSW"
     D_segment       434..440
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          124 c          155 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc ctgtgtgaga tacaactggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ctcaggcact actatctgac
      241 ctgggtccgc cagggtccag ggaaggggct ggagtggatc tcaggtatca acagtggtgg
      301 gagtagcaca tactatgcag actccgtgaa ggacagattc accatgtcca gagacaacgc
      361 caagaacaca ctgtatcttc aaatggacaa cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcgagg gggactgggg cgattcttgt gtactttgac tcctggggcc agggagccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006609             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13302:16141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006609
VERSION     KCXD01006609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13302:16141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65091.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       436..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          115 c          150 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gaacccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttattgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtagctatgg
      241 cttgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgacag ttatatcgtc
      301 tgatgaaagt aggaaatact acgcagactc tctgaaggac cgattcacca tttccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagggatg ataatggggt gcttatcgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006610             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:22800:3047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006610
VERSION     KCXD01006610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:22800:3047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65092.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          132 c          138 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 gtctatcaga agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattgggtat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagttga gcgctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006611             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17108:5709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006611
VERSION     KCXD01006611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17108:5709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65093.1"
                     /translation="CATADYGNSLDFW"
     D_segment       441..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          108 a          122 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagcttcg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatagtgt
      301 ctgatggaag tatgagatac tacgcagact ctatgaagga ccgattctcc atctccagag
      361 acaattccaa gaacatgcta tttcttcaag tgaacaacct gaaattggag gacactgccg
      421 tttattactg tgcgacagcc gactacggaa acagccttga cttctggggc ccggcagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01006612             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19190:5356
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006612
VERSION     KCXD01006612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19190:5356"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65094.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          110 a          121 c          159 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtaggctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aaggggctgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtgtattact gtactagaaa ccggaatact gtcatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006613             438 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15947:13734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006613
VERSION     KCXD01006613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 438)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 438)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15947:13734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..436
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..436
     V_segment       146..366
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <358..>405
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65095.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       376..382
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       392..436
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        437..>438
                     /gene="IGHG"
BASE COUNT           93 a          104 c          132 g          109 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcaactgga ttcagtttca gttactacta catgagttgg
      181 gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag tggtgggggt
      241 agcacattct atgcagactc cgtggagggc agattcacca tctccagaga gaacgccaag
      301 aacacactgt ctcttcacat ggacggcctg agacctgagg actcggctgt ttattactgt
      361 gcgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc gggagtcctg
      421 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006614             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14410:3329
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006614
VERSION     KCXD01006614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14410:3329"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..464
     V_segment       83..381
                     /gene="IGHV2-118"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65096.1"
                     /translation="CVRSVPFFEDDYGYFPYFDFW"
     D_segment       394..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          139 c          118 g          116 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tccacgctcc tgctgctgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcctg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcgc cttctctggg ttctcactca gcactagtgg
      181 tttgggtgtg gcctggatcc gtcagccctc acggaagacc ctggagtggc ttgcacacat
      241 taattggaat gatgatgagc gctacaatac atctctaaag agtaggctca ccatctccaa
      301 ggacaccgcc ataaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc
      361 cacatattac tgtgtacgga gtgtcccgtt tttcgaggat gattacggtt actttcctta
      421 ctttgacttc tggggccagg gagtcctggt cactgtctcc tcagcc
//
LOCUS       KCXD01006615             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21113:10196
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006615
VERSION     KCXD01006615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21113:10196"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..474
     V_segment       105..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65097.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       405..416
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..474
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT           98 a          138 c          136 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagcctttgg agaccctgtc cctcacctgc gctgtctctg
      181 gtggctccat cagcagtaac tactggagct ggatccgcca gtccccagga aagggactgg
      241 agtggattgg acgtatttct gggagtggtg ggagcaccgt ctacaacccc tccctcaaga
      301 gtcgagtcac cttttcaaca gacacgtcca agaacgagat ctccctgaaa gtgacctctg
      361 tgaccgccgc ggacacggcc gtatattatt gtgcgacagc cggatatagc agcagcgaaa
      421 gcttctacgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006616             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18108:5965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006616
VERSION     KCXD01006616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18108:5965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..441
     V_segment       87..380
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65098.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       390..395
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT          102 a           98 c          133 g          110 t
ORIGIN      
        1 acatggggac agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg
       61 ttgctatttt aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg
      121 ttcagccggg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct
      181 atggcatcca ctgggtccgc caggctccag ggaaggggct ggagtgggtg acagttatat
      241 cgtatgatga aacaaagaaa ttctacgcag actctctgaa ggaccgcttc atcatctcca
      301 gagacaattc caagaacatg gtatatcttc aaatgaataa cctgaaatta gaggacacgg
      361 ccgtatattt ctgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggtg
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006617             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10372:19200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006617
VERSION     KCXD01006617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10372:19200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65099.1"
                     /translation="CARVGEDTGGAEDLDFW"
     D_segment       449..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          113 a          119 c          158 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctcttttaag aggtgtccag tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctccgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga agggactgga ctgggtggca ctgatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccga gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttttg tgcgagagtt ggagaggata ctggtggtgc ggaggacctt gacttctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006618             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11617:8021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006618
VERSION     KCXD01006618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11617:8021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65100.1"
                     /translation="CARGDYGNSLDYW"
     D_segment       416..427
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          107 a          109 c          144 g          115 t
ORIGIN      
        1 acatgggggg aagtccacag tgttccattc ggtgatcagc acagaacaca gaggactcac
       61 catgaagttt gggctgagct gggttttcct tgttgctatt ttaagaggtg tccattgtga
      121 ggtgcagctg gtggagtctg gaggaggctt ggttcagcct ggggggtccc tgagactgtc
      181 ctgtgcagcc tctggattca ccttcattaa ctatggcatg cactgggtcc gccaggctcc
      241 agggaagggt ctggagtggg tggcagttat gtcgcatgat ggaactaaga aattctacgc
      301 agactctgtg aaggaccgat tcaccatctc cagggacaat tccaagaaca tggtatatct
      361 tcaaatgaac aacctgagat tggaggacgc ggccgtgtat tactgtgcga gaggagacta
      421 cggtaacagc cttgactact ggggccaggg agtcctgctc accgtctcct cagcc
//
LOCUS       KCXD01006619             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24701:10285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006619
VERSION     KCXD01006619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24701:10285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65101.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          135 c          129 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcagttgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagtt ataacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtcccag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggagcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006620             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:11278:5233
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006620
VERSION     KCXD01006620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:11278:5233"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65102.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       441..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          114 c          156 g          116 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gcggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcggaac ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggc ctggagtggg tgacggttat atcgaatgat
      301 ggaagtaaga aatactacgc ggactctgtg aaggaccgat tcagcatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacgtgaaat tggaggacac ggccgtctat
      421 tactgtgtga gagatgcgtt tggtagcggg cttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006621             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18884:10012
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006621
VERSION     KCXD01006621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18884:10012"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65103.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT          117 a          143 c          131 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccga ctacaccttc gccgaattac ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggttttgcta gtatatatgg tgaaataata
      301 catacagaga gattccaggg cagagtcacc atgacagcgg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc gatcaccatc
      481 tcctccgcc
//
LOCUS       KCXD01006622             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11383:6762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006622
VERSION     KCXD01006622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11383:6762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65104.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          116 c          150 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttctt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg gctccctgag actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtgac agttatatcg
      301 tatgatgaaa gtaagaaata ctacgcagac tctctgaagg accgattcac catttccaga
      361 gacaattcca agaacacgct atatcttcaa atgaacaacc tgcaattgga ggacacggcc
      421 gtatattact gtgcgagaga tgataatggg gtgcttatcg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006623             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:29171:13587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006623
VERSION     KCXD01006623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:29171:13587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..328
     V_segment       7..258
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65105.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       268..274
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..328
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           74 a           80 c           99 g           77 t
ORIGIN      
        1 acatgggggg ggtccctgag actttcctgc gcagcctctg gattcagctt caattattac
       61 tacatgagct gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaat
      121 agtggtgggg aaagtacgta ctatgcagag tccgtgaggg gcagattcac catctccaga
      181 gagaacgcca agaacacact atttcttcaa atggacagcc tgagaactga ggacacggct
      241 gtctattact gtgtgagaga tcgacgtgta cagtcgttat cctggttcga tgtctggggc
      301 ccgggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006624             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:25123:16003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006624
VERSION     KCXD01006624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:25123:16003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65106.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          134 c          137 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgcg gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatctatgg gagtgatagt agtaccaact acaacccctc cctcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccagtgct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006625             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27620:9870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006625
VERSION     KCXD01006625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27620:9870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..492
     V_segment       141..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65107.1"
                     /translation="CANALTGGLDYW"
     D_segment       439..447
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          122 c          158 g          110 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 ccactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aggtactgga
      241 tgaactgggt ccgccaggct ccaggaaagg ggctggagtg ggtctcagct attgcaagtg
      301 gtggagaaag cacatactat gcagactccg tgaagggccg attcaccgtc tccagagaca
      361 actcaaagaa cacagtctcc ctgcaaatga acagtcttag cgcggaggac acggccgtgt
      421 attactgtgc gaatgcgtta actgggggtc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006626             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:22483:15425
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006626
VERSION     KCXD01006626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:22483:15425"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65108.1"
                     /translation="CARYGDDSVHYNFDSW"
     D_segment       408..414
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          141 c          132 g          104 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcggcccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtggct tctggaactg gatccgccag cccccaggga aggggctgga
      241 atggattgga tatatctatg gtggtactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc gtttcaacag acacgtccaa gaaccagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacaccgccg tgtactactg tgcgagatat ggagatgaca gtgttcatta
      421 caactttgac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006627             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22148:9837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006627
VERSION     KCXD01006627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22148:9837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65109.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       442..449
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          114 a          118 c          144 g          133 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg ggattcccag gtgttttcat tcagagatca
       61 ggactgaaca cacaggactc accatggagt ttatgctgag ctgggttttc cttgttgcta
      121 tattaaaagg tgtccagtgt gtggagcagc tggtggaatc tgggggaggc ttggtacagc
      181 ctggggcgtc cctgagactc tcctgtgcag cctctgaatt caccttcagt tcctatgaca
      241 tgcactgggt tcgccaggct ccagggaagg gtctggagtg ggtttccggt attaacattg
      301 gcggtgacac atactaccca gactctgtga agggtcgatt cactatctcc agagacaatg
      361 ccaagaactc cttgtatctt caaatgaaca gcctgagagt tgaggacact gctgtgtatt
      421 tttgtacaag ggggatagat aactaccact ttagtaatac ggactttgac tactggggcc
      481 atggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006628             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:24223:17519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006628
VERSION     KCXD01006628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:24223:17519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..494
     V_segment       104..397
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65110.1"
                     /translation="CARDAGYGDTISLVDINMFPHFDYW"
     D_segment       415..438
                     /gene="IGHD3-20"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          101 a          137 c          140 g          118 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gctcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctggagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgtg ctgtctccgg
      181 tgcctccatc agcagttact ggtggagttg gatccgccag cccccaggga agggactgga
      241 gtggattggg gagatcaatg gtaatagtgg tagtttttac tacaaccctt ccctcatcag
      301 tcgagtctcc atttcaaaag acgcgtccaa gaatcacttc tccctgaagc taagctctgt
      361 gaccgccgcg gacacggccg tatattattg tgcgagagat gccgggtatg gggatacgat
      421 atcactagtc gatattaata tgttccccca ctttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006629             341 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21183:11625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006629
VERSION     KCXD01006629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 341)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 341)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21183:11625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..339
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..339
     V_segment       1..264
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <258..>308
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65111.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       270..290
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       295..339
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        340..>341
                     /gene="IGHG"
BASE COUNT           69 a          102 c           88 g           82 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcgcctgcgt tgtctctggt ggctccatca
       61 gcgattactc ctggagctgg atccgccagc ccccagggaa gggactggag tggattggga
      121 atattgatgt tcatcttgcg ggccccaact acaacccctc cctcaagagt cgagtcgcca
      181 tttcaaaaga cacgtccaag aatcagttct ccctgaagct gagctctgtg accgccgcgg
      241 acacggccgt atatttctgt gcgaaacaat atagtggtag ttattactac tcccactttg
      301 acttctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006630             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20003:10512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006630
VERSION     KCXD01006630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20003:10512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65112.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           97 a          135 c          129 g          109 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggacaggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtagc tactggaatt ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacatgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006631             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13535:18580
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006631
VERSION     KCXD01006631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13535:18580"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65113.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       398..406
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          136 c          139 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctctggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatgagc agtcactact gcagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgg atctctggta gtggtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatc tcaacagaca cgtccaagaa ggagatctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagaagac tatggtggta attattattt
      421 taaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006632             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12434:5690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006632
VERSION     KCXD01006632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12434:5690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65114.1"
                     /translation="CVRGMDNYHHINTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          114 a          120 c          146 g          127 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggagcatctg gtggagtctg ggggaggctt ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgg ctatgacatg
      241 cactgggtcc gccaggctcc agggaagggt ctggagtggg tttcaggtat taacattggc
      301 gatgacccat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagagctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccaccac attaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006633             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11011:18133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006633
VERSION     KCXD01006633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11011:18133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65115.1"
                     /translation="CARVDTSTLDATAADYW"
     D_segment       438..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          117 a          120 c          152 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggcgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca cttatatcgt
      301 ttgatggaag taagcaatat tacgcagact ctgtgaagga ccgattcacc atctctagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagagtg gatacatcta cacttgatgc aacagcagct gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006634             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:19417:2642
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006634
VERSION     KCXD01006634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:19417:2642"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..460
     V_segment       76..372
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <364..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65116.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       381..403
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           95 a          134 c          124 g          109 t
ORIGIN      
        1 acatgggggt gcaagaacat gaagcacctg tggttcttcc tcctcctggt ggcagctccc
       61 agatgggtcc tgtcccaggt gcagctgcag gagtcgggcc caggactggt gaagccttcg
      121 gagaccctgt ccctcacatg cgctgtctct ggtggctcta tcagcagtac taaatggtgg
      181 aactggatcc gccagccccc agggaaaggg ctcgagtgga ttgggtatat cagtggtagt
      241 agtggtaaca cctactacaa cccctccctc aagagtcgag tcaccatttc aacagacacg
      301 tccaacaacc agttctccct gaagctgagc tctgtgaccg ccgcggacac ggccttttat
      361 tattgtgcga gatcccaatc atattgtagt gggctttact gcttcggcta ctactacttt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006635             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:7662:12050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006635
VERSION     KCXD01006635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:7662:12050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65117.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       439..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          115 c          152 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg gggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaacttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttca
      301 tctgatggaa gtaacaaata ctacgcaaac tctgtgaagg accgatttac catctccaga
      361 gacaattcca agaacatagt atatcttcaa atgaacaacc tgaaatcgga ggacacggcc
      421 gtctattact gtgcgagaga tgatatgggg accggttttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006636             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9917:14939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006636
VERSION     KCXD01006636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9917:14939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65118.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       417..425
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          139 c          145 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aagtgaggaa gcctggggtc tcagtaaagg
      181 tctcctgcaa ggtttccgga aacaccatca ccgaattatc cgtgcactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatggggg gtgttgatcc cgtctatggt gaaataagac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtcgaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ctattactgt gcgcgaggat
      421 attgtcatgg tagttactgt tcctcgggtc ttgtctcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006637             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14635:9602
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006637
VERSION     KCXD01006637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14635:9602"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65119.1"
                     /translation="CTGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          103 a          129 c          155 g          104 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcgc tactggatga
      241 actgggtccg ccaggctcca ggaaagggac tggagtgggt ctcagctatt aatagtgatg
      301 gggagaacac atacttcgca gactccgtga agggccgatt ctccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgagacc ggaggacacg gccgtgtatt
      421 actgcacggg cggggcgtac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006638             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7151:15765
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006638
VERSION     KCXD01006638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7151:15765"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65120.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       428..434
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          139 c          151 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgcaaatgg tgaaataata
      301 cacgcagatg gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 aggttcggta gtagcgtctg gtccaatctc gtctatggtt tcgattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006639             344 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15448:13137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006639
VERSION     KCXD01006639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 344)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 344)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15448:13137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..342
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..342
     V_segment       8..267
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>311
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65121.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       273..293
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       298..342
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        343..>344
                     /gene="IGHG"
BASE COUNT           72 a          102 c           89 g           81 t
ORIGIN      
        1 acatgggggt gaaaccttcg gagaccctgt ccctcgcctg cgttgtctct ggtggctcca
       61 tcagcgatta ctcctggagc tggatccgcc agcccccagg gaagggactg gagtggattg
      121 ggaatattga tgttcatcta gcgggcccca actacaaccc ctccctcaag agtcgagtcg
      181 ccatttcaaa agacacgtcc aagaatcagt tctccctgaa gctgagctct gtgaccgccg
      241 cggacacggc cgtatatttc tgtgcgaaac aatatagtgg tagttattac tactcccact
      301 ttgacttctg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006640             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19156:18441
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006640
VERSION     KCXD01006640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19156:18441"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..325
     V_segment       7..258
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65122.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       265..272
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..325
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           73 a           83 c           96 g           75 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgc gcagcctctg gattcagctt cagttatttc
       61 tacatgagct gggtccgtca ggctccagga aaggggctgg agtggatctc aagtattgac
      121 aatggtggga ctaccacaaa ttttgcagac tccgtgaggg gcaggttcac catctccaga
      181 gagaacgcca agaacacact gtatcttcaa atggacagcc tgagagctga ggacacggct
      241 gtctattatt gtgcgagagc gcgcggggtg atcattacat actttgactc ctggggccag
      301 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006641             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8351:14786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006641
VERSION     KCXD01006641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8351:14786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65123.1"
                     /translation="CARDSDSREFSFDYW"
     D_segment       449..453
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          121 c          144 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggttcacc tgctggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agctatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggactg ggtggcagtt atatcgtatg
      301 atggaagtaa gaaatactac gcagactctg tgaatgaccg attcaccatc tccagagaca
      361 attccaacaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgc gagagattcc gactcccgag aattcagttt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006642             394 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:24001:15864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006642
VERSION     KCXD01006642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 394)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 394)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:24001:15864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    39..392
                     /note="immunoglobulin heavy chain variable region"
     V_region        39..392
     V_segment       39..329
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <323..>361
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65124.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       336..348
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       351..392
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        393..>394
                     /gene="IGHG"
BASE COUNT           73 a          118 c          117 g           86 t
ORIGIN      
        1 acatgggctg gtggcagctc ccagatgggt cctgtccgag ctgcagctgc aggagtcggg
       61 cccaggactg gtgaagcctt cggagaccct gtctgtcacc tgcgctgtct ctggtgactc
      121 aatcagcagt tacttctgga actggatccg ccaggcccca gggaagggac tggagtggat
      181 tgggtttctc tatggtagtg atagtacctc caactacaat ccctccctca agagtcgagt
      241 caccctgtct gtggacacgt ccaacaacca ggtctccctg atgctgaact ctgtgaccgc
      301 cgcggacacg gccgtctatt actgtgcgac cgggaagcgg cagctggatc ttgactactg
      361 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006643             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:13278:18371
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006643
VERSION     KCXD01006643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:13278:18371"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65125.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       450..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          118 c          157 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga ggctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactttg
      241 gcgtgcactg ggtccgccag gctccaggga aggggctgga gtggatggcg gttatttcgt
      301 ctgatggagg taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctg attcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gcatttggta gcggctgtga cttctggggc ccgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006644             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9184:6534
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006644
VERSION     KCXD01006644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9184:6534"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65126.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       423..431
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          142 c          136 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaact acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg tagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagcagcct gacatctgag gacacggccg tgtattactg cgcgattggc cctagtggca
      421 gatggaacga ctggtccttc gacatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01006645             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16377:9426
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006645
VERSION     KCXD01006645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16377:9426"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..425
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65127.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       441..448
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          115 a          120 c          146 g          127 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg gattcccagg tgttttcatt cagagatcag
       61 gactgaacac acaggactca ccatggagtt tatgctgagc tgggttttcc ttgtttctat
      121 attaaaaggt gtccagtgtg tggagcatct ggtggagtct gggggaggct tggtacagcc
      181 tggggcgtcc ctgagactct cctgtgcagc ctctgaattc accttcagtg gctatgacat
      241 gcactgggtt cgccaggctc cagggaaggg tctagaatgg gtatcaggta ttaacattgg
      301 cggtgaccca tactacccag actctgtgaa gggtcgattc accatctcca gagacaacgc
      361 caagaactcc ttgtatcttc aaatgaacaa cctgagacct gaggacactg ctgtgtatta
      421 ttgtgtgagg gggatggata actaccactt cagtaatacg gactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006646             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21682:4480
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006646
VERSION     KCXD01006646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21682:4480"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65128.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       446..451
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          116 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagag cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctctgg
      241 catgcactgg gtcctccagg ctccagggaa ggggctggag tgggtggcag taaaatcgtt
      301 tgatggaact aagatatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg cctacgggag cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006647             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10280:18305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006647
VERSION     KCXD01006647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10280:18305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..500
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65129.1"
                     /translation="CARGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          115 a          141 c          150 g           98 t
ORIGIN      
        1 acatgggggc accacacaac aaccacatcc ctcgcctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaagtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtcgcctgca aggtttccgg aaacaccttc accgaattat tcatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgtcgatc ctgctcaagg tgaaataata
      301 tacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgagaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc tgcc
//
LOCUS       KCXD01006648             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11828:6935
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006648
VERSION     KCXD01006648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11828:6935"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..453
     V_segment       90..382
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65130.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       395..403
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           93 a          132 c          132 g           98 t
ORIGIN      
        1 acatgggagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc ttcctcctcc
       61 tggtggcagc tcccagatgg gtcctgtccc agctgcagct gcaggagtcg ggcccaggac
      121 tggtgaagcc tccggagacc ctgtccctca cctgcgctgt ctctggtggc tctatcagca
      181 gtagttactg cagctggatc cgccagaccc cagggaaggg actggagtgg attggctata
      241 tatatgggag tgatagtagc accaactaca acccctccct caagagtcga gtcaccctgt
      301 cagtagacac gtccaagaac cagtgctccc tgaaggtgag ctctgtgacc gccgcggaca
      361 cggccgtgta ttattgtgcg agttcgggta tagaagtggt tgcctacagc attgactact
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006649             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15129:13529
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006649
VERSION     KCXD01006649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15129:13529"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65131.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          117 c          160 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagccgg
      181 gggggtccct aagactctcc tgtgcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tggagtgggt ctcaactatt aatagtggtg
      301 gggacaacac atattacgca gactccgtga agggccgact taccatttcc agagacaact
      361 caaagaacac gctcctcctg caaatgaaca gcctgagagt ggaggacacg gccgtgtatt
      421 actgtgttca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006650             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6013:8419
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006650
VERSION     KCXD01006650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6013:8419"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    78..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        78..438
     V_segment       78..368
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <360..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65132.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       371..386
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       390..438
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           88 a          110 c          139 g          103 t
ORIGIN      
        1 acatgggcag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
       61 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcccg
      121 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      181 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagccatt agtgttggtg
      241 gtagtacata ttacgcagac tccgtgaggg gccgattcac catctccaga gacaactcag
      301 agaacacgct ctccctgcaa atgaacagcc tgacagctga ggacacggcc gtgtattact
      361 gtgcgaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caaggggccg
      421 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006651             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19512:17540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006651
VERSION     KCXD01006651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19512:17540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..416
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65133.1"
                     /translation="CASERCTSSVCAGFLDSW"
     D_segment       418..422
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          147 c          135 g          101 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag
      121 tcccaggtcc acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa
      181 atttcctgcg gggcttctgg attcaccttc gacacccatg gtatcaactg ggtgcgacag
      241 gcccctggac aaggacttca gtggatggga gtgatcatcc cccttattgg tatcaccaac
      301 tacgcaaaga actctcaggg cagagtcaca ctaaccgcgg acacgtccac aaacacagcc
      361 tacatggagc tgaacagcct gagatttgag gacacggcca tctactactg tgcgagtgaa
      421 cgctgcactt ctagtgtttg cgccgggttc cttgactcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006652             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22714:8593
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006652
VERSION     KCXD01006652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22714:8593"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65134.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       440..447
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          109 a          130 c          149 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctggctt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggagga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcattg ggtccgccag gctccaggga aggggctgaa atgggtctca tctattagta
      301 gtggtggtct cacatactac gcagactccg tgaagggccg atttgccatc tccagagaca
      361 actcaaagaa cacgctctcc ctgcaaatga acagcctgag cgctgaggac acggccgtat
      421 attactgtgc gaaaggaggt agcagctctt tctattggta cttcgatatc tggggccctg
      481 gcaccccagt gaccatctcc tcagcc
//
LOCUS       KCXD01006653             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9902:19112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006653
VERSION     KCXD01006653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9902:19112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65135.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          118 a          114 c          150 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgcaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006654             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11091:20218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006654
VERSION     KCXD01006654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11091:20218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65136.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       413..419
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..468
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           92 a          143 c          130 g          105 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcac ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cgcctgcgct gtttctggtg
      181 actccatcaa cagtggctac tactggagct ggatccgcca acccccagag aaggggctgg
      241 agtggattgg gtttttcggt ggtagtagtg gtagcaccta ctacaacccc tccctcaaga
      301 gtcgagtcac cctttcaaaa gacacgtcca ggaaccagtt ctccctgaaa ctgacctctg
      361 tgaccgccgc ggacacggcc gtctattact gtgcgagaaa acttccaggt ctgcaactaa
      421 ccggtttcga ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006655             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5569:18795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006655
VERSION     KCXD01006655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5569:18795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65137.1"
                     /translation="CAIGPSGTWNGWSFDVW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          100 a          145 c          140 g           96 t
ORIGIN      
        1 acatggggag catcacacaa cagccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgtatatg gtgaaatggt
      301 gttccagggc ggggtcacca tgaccgagga cacgtctaca gacacagcct acttggagct
      361 caacagcctg agctctgaag acacggccgt gtactactgt gcgattggcc ctagcggcac
      421 ctggaacggc tggtccttcg atgtctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01006656             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:16984:10161
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006656
VERSION     KCXD01006656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:16984:10161"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65138.1"
                     /translation="CARGIDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          116 a          115 c          151 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagttggtgg agtctggggg aggattggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtgtc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactttagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006657             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7449:13486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006657
VERSION     KCXD01006657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7449:13486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..459
     V_segment       105..401
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65139.1"
                     /translation="CARWSAANFDYW"
     D_segment       406..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           93 a          131 c          138 g           99 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acctcctggg caagaacatg aggcatctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg caactgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gatgtctctg
      181 ggggctccat cagcagtggt tatggctgga gctggatccg ccagccccca gggaaggggc
      241 tggagtggat tgggtgtatc tacgatagta gtggaaacac ctactacaac ccctccctca
      301 agagtcgagt caccatttca aaagacacgt ccaagaacca gttctccctg aagatgaggt
      361 ctatgaccgc cgcggacgcg gccgtgtatt attgtgcgag atggtcggca gccaactttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006658             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20922:7542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006658
VERSION     KCXD01006658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20922:7542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..467
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65140.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       408..415
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..467
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          150 c          122 g          103 t
ORIGIN      
        1 acatgggatg ctctctgaga gtcacggaca tcctgtacaa gaacatgcgg tatctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcac ctgcaggagt
      121 cgggcccagg actggggaag ccttcagaaa ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag tcgtaactgg tggagttgga tccgccagcc cccagggaag ggactggagt
      241 ggattggacg tatctctggt agtcttggaa gtaccagcta caacccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tatttctgtg cgagacattc agaccccgca actactagct
      421 ggtacttcga tctctggggc ccggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01006659             423 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12107:4825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006659
VERSION     KCXD01006659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 423)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 423)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12107:4825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    52..421
                     /note="immunoglobulin heavy chain variable region"
     V_region        52..421
     V_segment       52..345
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <337..>390
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65141.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       346..350
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       380..421
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        422..>423
                     /gene="IGHG"
BASE COUNT           90 a          121 c          123 g           89 t
ORIGIN      
        1 acatggggga ggctcctctt tgtggtggca gcagctgcag gtgtccagtc ccaggtccac
       61 ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaaaat ttcctgcggg
      121 gcttctggat tcaccttcga cacccatggt atcaactggg tgcgacaggc ccctggacaa
      181 ggacttcagt ggatgggagt gatcatcccc cttattggta tcaccaacta cgcaaagaac
      241 tctcagggca gagtcacact aaccgcggac acgtccacaa acacagccta catggagctg
      301 aacagcctga gatttgagga cacggccatc tactactgtg cgagagaacg ctgcacttct
      361 agtgtttgcg ccgggttcct tgactcctgg ggccagggag tcctggtcac cgtctcctca
      421 gcc
//
LOCUS       KCXD01006660             365 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:27107:15392
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006660
VERSION     KCXD01006660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 365)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 365)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:27107:15392"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    50..363
                     /note="immunoglobulin heavy chain variable region"
     V_region        50..363
     V_segment       50..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>332
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65142.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       291..308
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       313..363
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        364..>365
                     /gene="IGHG"
BASE COUNT           81 a          103 c          102 g           79 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgcgctg
       61 tctctggtgg ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg
      121 ggctggagtg gattggatat atcagtgcta gtagtgggac caccgactac aacccctccc
      181 tcaagagtcg agtcaccatt tcaagagaca cgtccaagaa cctcttctcc ctgaacctga
      241 gctctgtgac cgccgcggac acggccgtgt attactgtgc gagagagaaa tactatagtg
      301 gtagttataa acacaactgg ttcgatgtct ggggcccggg agtcctggtc gccgtctcct
      361 cagcc
//
LOCUS       KCXD01006661             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23309:6378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006661
VERSION     KCXD01006661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23309:6378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65143.1"
                     /translation="CAAGHSGSWNYWYFDFW"
     D_segment       428..439
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          139 c          143 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctgc agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg gggtgttgat cctgcatttg gtgaaatgat
      301 acacgtagag aggttccagg gcagagtcac tctgaccgag gacacgtcta cagatacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtgtttttct gtgcagccgg
      421 acatagtggc agctggaact actggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006662             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19844:11443
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006662
VERSION     KCXD01006662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19844:11443"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65144.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          115 c          151 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtcactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggat tgggtggcag ttatgtcgtt
      301 tgatgaaaat gtgaagttct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtattactgt gcgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006663             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18011:5520
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006663
VERSION     KCXD01006663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18011:5520"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..358
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..358
     V_segment       8..299
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <291..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65145.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       302..310
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       321..358
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        359..>362
                     /gene="IGHG"
BASE COUNT           84 a           82 c          115 g           81 t
ORIGIN      
        1 acatgggggt gcagctggtg gagtctggag gaggcttggt tcagcctggg gggtccctga
       61 gactctcctg tgcagcctct ggattcacct tcagttacta tggcatgcac tgggtccgcc
      121 aggctccagg gaaggggctg gagtgggtgg cagttatgtc gaatgatgga agtaagaaat
      181 actacggaga ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacaggc
      241 tatatcttca aatgaacaac ctgaaattgg aggacacggc agtgtattac tgtgcgagag
      301 atgatagtgg ggtgatcatc gactactggg gccagggagt cctggtcacc gtctcctccg
      361 cc
//
LOCUS       KCXD01006664             313 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22648:16281
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006664
VERSION     KCXD01006664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 313)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 313)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22648:16281"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..311
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..311
     V_segment       6..241
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <233..>280
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65146.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       251..257
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       267..311
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        312..>313
                     /gene="IGHG"
BASE COUNT           67 a           83 c           90 g           73 t
ORIGIN      
        1 atgggtctcc tgcgcagcct ctggattcag cttcagttac tacttcatga gttgggtccg
       61 ccaggctcca gggaaggggc tggagtggat ctcaggtatt accagtggtg gggataacac
      121 atactctgca gactccgtga agggcagatt caccatctcc agagagaacg ccaagaccac
      181 actgtatctt cacatggaca gcctgagagc tgaggacacg gctgtctatt actgtgcaag
      241 agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag tcctggtcac
      301 cgtctcctca gcc
//
LOCUS       KCXD01006665             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18696:4952
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006665
VERSION     KCXD01006665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18696:4952"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65147.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       419..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          137 c          139 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactgga tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggggg tgttgatcct gaatatggtg aaatgacaca
      301 cgtagagaaa ttccagggca gagtcacctt gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tatttctgtg cagccggata
      421 tagtggcagc tggaactcct ggtacttcga tttctggggt cctggcaccg caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006666             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22491:13349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006666
VERSION     KCXD01006666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22491:13349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65148.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       409..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          150 c          131 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtctccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      301 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggagctgac
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg gttggcccta gcggcacttg
      421 gaaccactgg cccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006667             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13054:19177
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006667
VERSION     KCXD01006667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13054:19177"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65149.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       434..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          103 a          125 c          157 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagg tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatgcta
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagcc attagtgttg
      301 gtggtagtac atactacgca gactccgtga ggggccgatt caccatctcc agagacaact
      361 cagatagcac gctctccctg caaatgaaca gcctgagtac tgaggacacg gccgtgtatt
      421 actgtgccaa aggggataca gctacagttt attacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006668             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:8592:12599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006668
VERSION     KCXD01006668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:8592:12599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..438
     V_segment       84..377
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <369..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65150.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       378..383
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT          102 a          123 c          126 g           89 t
ORIGIN      
        1 acatggggag agcacagcac ctcaccatgg actggacctg gaggctcctc ctcttggtgg
       61 cagcagctac aggcgcccac tccgaggtcc agctggtaca gtctggggct gaggtgaaga
      121 agcctggggc ctccgtgaaa atctcctgcc aggcttccgg atacacctta accgaccact
      181 acctacactg ggtgcgacag gctcctggaa aaggacttga gtggatggga ggtattcttc
      241 ctgagtatgg taaagttgac tacacacaga agttccaaga cagagtcacc atcaccgcgg
      301 acatgtcgac agagacagtc tacatggagc tgagcagcct gagatctgag gacacggccg
      361 tttattactg tgtgacagtg ggtccctacc attactttga ctactggggc cagggagccc
      421 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006669             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16534:9062
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006669
VERSION     KCXD01006669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16534:9062"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65151.1"
                     /translation="CAGGSRRQPDTW"
     D_segment       406..413
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           82 a          138 c          140 g           97 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagagcatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca agactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtgggcctg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatcggtg gtactagtgg gagcacctac tacaacccct ccctcaggag
      301 tcgagtcatc atttcaacag acacgtccaa gaatcacttc tccctgaagc tgacctctct
      361 gaccgccgcg gacacggccg tgtattattg tgcgggcgga agtcggcggc agccggatac
      421 ctggggccag ggagtcctgg tcaccgtctc gtcagcc
//
LOCUS       KCXD01006670             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:24865:18002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006670
VERSION     KCXD01006670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:24865:18002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..459
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65152.1"
                     /translation="CARVRGVNIHYFDCW"
     D_segment       407..411
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>463
                     /gene="IGHG"
BASE COUNT           86 a          141 c          137 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcaga ggttaccact ggacctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtct gtcagtgata gtggtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaactgaca cgtccaagaa ccagttctcc ctgaagctga tttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgtaaata tccactactt
      421 tgactgctgg ggccagggag ccctggtcac cgtcgcctcg gcc
//
LOCUS       KCXD01006671             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16856:10022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006671
VERSION     KCXD01006671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16856:10022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..489
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65153.1"
                     /translation="CAAGLGGYLVLTEYLEFW"
     D_segment       425..431
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>493
                     /gene="IGHG"
BASE COUNT          111 a          140 c          140 g          102 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga agtgaagagg cctggggcct cagttaaggt
      181 ctcctgcaag gtttccggat actccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct gtgtatggtg aagaaataca
      301 cgcagagaat ttccaggaca gattcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagctg agcagcctga gacctgagga cacggccgtg tatttctgtg cggcgggcct
      421 tgggggatat ttagttctta ctgaatacct cgaattctgg ggccagggcg ccctggtcac
      481 cgtctcctcc gcc
//
LOCUS       KCXD01006672             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15552:3388
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006672
VERSION     KCXD01006672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15552:3388"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..505
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65154.1"
                     /translation="CARVTGIDGTSVEYFDFW"
     D_segment       436..450
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..505
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          117 c          151 g          124 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tggagcctct ggattcacct tcagtagtta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatatc atttgatgga
      301 actaagaaat actacgcaga ctctgtgacg gaccgattca ccatctccag agacgattcc
      361 aagaatttgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtatattac
      421 tgtgcgagag taaccggtat agatggaact tccgttgaat acttcgactt ctggggccag
      481 ggcgccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006673             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11467:14355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006673
VERSION     KCXD01006673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11467:14355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65155.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           86 a          142 c          134 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtacctact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtctccatt tcaagagaca cgtccaggaa ccagttctcc ctgcagctgg attatgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006674             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:11613:14906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006674
VERSION     KCXD01006674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:11613:14906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65156.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       409..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          137 c          129 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtaacttct ggatctggat ccgccagccc ccagggaagg ggctggagtg
      241 gatagggtct atctatggta gtactgggag caccttttac gacccctccc tcaagggtcg
      301 agtcaccatt tcaacagaca cgtccaagaa cctattttcc ctgaagctgg actccgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatagc gatactgata gttattactt
      421 ctttgactac tggggccagg gagtccgggt caccgtctcc tcagcc
//
LOCUS       KCXD01006675             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7768:13366
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006675
VERSION     KCXD01006675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7768:13366"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..485
     V_segment       131..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65157.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       433..439
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          109 c          149 g          117 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcacc tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgtag cctctggatt caccttcagg agttatggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg atgtaagtaa
      301 gaaatattac gcagacgctg tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 cacgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt attactgtgg
      421 gagagatgat aatggggtgc ttatcgacta ctggggccag ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01006676             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:12578:15265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006676
VERSION     KCXD01006676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:12578:15265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65158.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       425..440
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          118 a          143 c          137 g           96 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 attctgaggt ccagctggtg caatctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctttatat ggtgaaatga
      301 tacacacaga acagttccag ggcagagtca ccctgaccga ggatacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgagtg
      421 gccctagcgg cagctggaac gactggtact tcgatatctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01006677             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:15210:10692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006677
VERSION     KCXD01006677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:15210:10692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65159.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       446..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          111 a          118 c          153 g          116 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctggaggagg cttggttcgg
      181 ccgggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttttggc
      241 atccactggg tccgccaggc tccagggaag ggcctggagt gggtggcagt tatatcgtct
      301 gatgaaagta agaaatacta cgcagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatgctata tcttcaaatg aacaacctga agttggagga cacggccgtc
      421 tattactgtg cgagagacgc atatggcagc ggctgtgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006678             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:28892:12892
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006678
VERSION     KCXD01006678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:28892:12892"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..509
     V_segment       140..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65160.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       436..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..509
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          111 a          120 c          163 g          117 t
ORIGIN      
        1 acatggggct gggagaggag cccaggcctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tggtctgacc tgggttttcc ttgttggtct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct ggaggagcct tggctcagcc
      181 tggggggtcc ctgagactct cctgtgcagc gtctgggttc accttcagta gctatgccat
      241 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagcca tatcgtttga
      301 tggaagtaag aagaactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ctccaagaac atgctatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ctactgttcg agggagtgga tacagtgggc gcagttagtg agcggtttgg attcctgggg
      481 ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006679             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18541:6974
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006679
VERSION     KCXD01006679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18541:6974"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65161.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           88 a          142 c          130 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctgctgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcacc agtggcttct ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atctctggtg ctactgggag taccagctac accccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctgc actctgtgac
      361 cgccgcggat accgccgtgt attactgtgc gagatatgac gcggatgatt acggttatta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006680             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7320:18673
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006680
VERSION     KCXD01006680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7320:18673"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..441
     V_segment       75..360
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <357..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65162.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       376..383
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           99 a          105 c          124 g          115 t
ORIGIN      
        1 acatgggagg actcaccatg gagtttatgc tgagctgggt tttccttgtt tctatattaa
       61 aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta cagcctgggg
      121 cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat gacatgcact
      181 gggttcgcca ggctccaggg aagggtctag aatggctatc aggtattaac attggcggtg
      241 acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac aacgccaaga
      301 actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg tattattgtg
      361 tgagggggat ggataactac cacttcagta atacggactt tgactactgg ggccagggag
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006681             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:8369:10124
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006681
VERSION     KCXD01006681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:8369:10124"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..458
     V_segment       83..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65163.1"
                     /translation="CARVQGGSYYYGGGYFEFW"
     D_segment       387..403
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..458
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT          100 a          136 c          117 g          107 t
ORIGIN      
        1 acatggggga ctcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggtcttgt cccaggtgac cttgaaggag tctggtcttg cgctggtgaa
      121 acccacacag accctcacgc tgacctgcac tttctctggg ttctcattca gttcttctgg
      181 aacaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaagcat
      241 ttattggaat gatactaaat tccacagcac aacgctgaag ttcaggctca ccatctccaa
      301 ggacacctcc aaaaaccagg tggttctaac aataaccaac gtggaccctg tggacacagc
      361 cacatattac tgtgcacggg tacaaggtgg tagttattac tacggtgggg gatacttcga
      421 gttctggggc cagggcgccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006682             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:24582:4878
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006682
VERSION     KCXD01006682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:24582:4878"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65164.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          101 a          123 c          161 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt cggggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaatagt
      301 ggtggggatg atacatacta tgcagactcc gtgaagggcc gattcacctt gtccagagag
      361 aacgccaaga acacactgta tcttcacatg gtcagcctga gaggtgagga cacggctgtc
      421 tattactgtg cgagagaccg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006683             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:12851:17791
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006683
VERSION     KCXD01006683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:12851:17791"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65165.1"
                     /translation="CGRDDNGVIIDFW"
     D_segment       440..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          109 c          152 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagctt ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaagaa atactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaaatt gaaggacacg gccgtgtact
      421 actgtgggag agatgataat ggggtgatta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006684             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:4873:13537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006684
VERSION     KCXD01006684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:4873:13537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65166.1"
                     /translation="CVRGMDNYHFINTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          114 a          120 c          146 g          133 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtttc aggtattaac
      301 attggcgatg acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg accaacctga gagttgagga cactgctgtg
      421 tattattgtg taagggggat ggataactac cacttcatta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006685             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14709:10263
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006685
VERSION     KCXD01006685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14709:10263"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65167.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       359..366
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       371..410
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           82 a           92 c          130 g          108 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggcttggt tcagcctcgg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtagttt tggcatgcac tgggtccgcc aggctccagg
      181 gagggggctg gagtgggtgg cagttatgtc gtctgatgga agtaacatat actacgcagc
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatgt tatatcttca
      301 aatgaacaac ctgcaatttg aggacacggc cgtgtattac tgtgcgagag atgtgtacgg
      361 tagtgggtta gactactggg gcctgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006686             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13233:10581
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006686
VERSION     KCXD01006686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13233:10581"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    132..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        132..486
     V_segment       132..425
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65168.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       429..441
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          111 a          112 c          145 g          120 t
ORIGIN      
        1 acatgggagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc agcacagaac
       61 acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct attttaagag
      121 gtgtccagtg tgaggtgcag ttggcggagt ctggaggagg cttggttcag cctggggggt
      181 ccctgagact ctcctgtgca gcctctggat tcaccttcag taactttggc atgcactggg
      241 tccgtcaggc tccaggaaag gggctggagt gggtggcagt tatctcgtct gatggaagtt
      301 acaaatacta cgaagactct ttgaaggacc gattcaccat ctccagagac aattccagga
      361 acatgcaata tcttcagatg aacaacctga aattggagga cacggccgtg tatttctgtg
      421 cgagagggga atacagtaac tctattgact tctggggcca gggagtcctg gtcaccgtct
      481 cgtcagcc
//
LOCUS       KCXD01006687             449 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12482:15664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006687
VERSION     KCXD01006687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 449)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 449)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12482:15664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..447
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..447
     V_segment       93..389
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <381..>416
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65169.1"
                     /translation="CARWSAANFDYW"
     D_segment       394..400
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..447
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        448..>449
                     /gene="IGHG"
BASE COUNT           87 a          129 c          133 g          100 t
ORIGIN      
        1 acatggggag agtcacggac ctcctgggca agaacatgaa gcatctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt ggctccatta
      181 gtagtggtta tggctggagc tggatccgcc agcccccagg gaagggcctg gagtggattg
      241 ggtgtctcta tgatagtagt gggaacacct actacaatcc ctccctcaag agtcgagtca
      301 ccatttcaaa ggacacgtcc aagaaccagt tctccctgaa gctgaggtct atgaccgccg
      361 cggacacggc cgtctatttt tgtgcgagat ggtcggcagc caactttgac tactggggcc
      421 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006688             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11483:5779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006688
VERSION     KCXD01006688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11483:5779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..328
     V_segment       7..253
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65170.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       261..269
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..328
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           74 a           88 c           90 g           78 t
ORIGIN      
        1 acatgggggg cctcagtgag ggtctcctgc aaggtttccg gacacacctt cagcgaatta
       61 tccattcact gggtgcgaca ggcccccgga aaagggcttg agtgggtggg aggttttgct
      121 cctatatatg gtgaaatcct acacacagac aagttccagg gcagagtcac cttgaccgag
      181 gacacgtcta cagacaccgc ctatatggag ttgagcagcc tgagatctga ggacacggcc
      241 gtatattact gtgtggcggc tgatagtggt tacccttttt actacttcga tatctggggc
      301 cctggcaccc caatcatcat ctcctcagcc
//
LOCUS       KCXD01006689             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12341:17106
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006689
VERSION     KCXD01006689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12341:17106"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65171.1"
                     /translation="CATGPSGTWNAWYLDMW"
     D_segment       417..427
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          111 a          142 c          135 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg atacagcttc accgaattat ccatacactg ggtgcggcag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctttatatgg tgaaatgaag
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga catctgagga cacggccgtt tattactgtg cgactggccc tagcggcacc
      421 tggaacgcct ggtacctcga tatgtggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01006690             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:13219:2608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006690
VERSION     KCXD01006690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:13219:2608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65172.1"
                     /translation="CVQGEIFGVGLDFW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          116 c          163 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcac
      181 agcctggggg gtccctgaga ctctcctgtt cagcctctgg gttcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctcc ggtattaata
      301 gtggtgggga tactacatac tacgtagact ccgtgaaggg ccgattcacc atgtccagag
      361 acaattcaaa gaacactctc tccctgcaaa tgaacagcct gagagcggag gacacggccg
      421 tgtattattg tgtgcaaggg gaaatttttg gagtgggttt ggatttctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006691             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:16442:18004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006691
VERSION     KCXD01006691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:16442:18004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65173.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          122 a          141 c          135 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtgctt cgatatctgg ggccctggca ccccgatcac
      481 catctcctca acc
//
LOCUS       KCXD01006692             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:10783:15293
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006692
VERSION     KCXD01006692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:10783:15293"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65174.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           96 a          136 c          128 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcaaggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttcta ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggcagt atctctggtg cttatgggag caccagttat aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006693             340 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:24525:3805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006693
VERSION     KCXD01006693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:24525:3805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..338
     V_segment       7..268
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <260..>307
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65175.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       277..284
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..338
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>340
                     /gene="IGHG"
BASE COUNT           75 a           96 c           91 g           78 t
ORIGIN      
        1 acatggggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtgactccat
       61 cagcagtagc tactggaact ggatccgcca gcccccaggg aagggactgg agtggattgg
      121 gtatatctat ggtagtactg ggagcaccgg ctacaatccc tccctcaaga gtcgagtcac
      181 catttcaaca gacacgtcca agaaccagtt ctccctgaag ttgaactctg tgatcgccgc
      241 ggacaccgcc gtgtattact gtgcgagata tggagatgat agtgttcatt acaactttga
      301 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006694             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:18143:13448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006694
VERSION     KCXD01006694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:18143:13448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65176.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       434..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          112 c          154 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttctattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgac gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagctt ctggattcac cttcagtaac tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt ggcagttatg tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca ccctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag agatgtcttt ggcgggggac ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006695             435 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:21547:10146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006695
VERSION     KCXD01006695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 435)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:21547:10146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..433
     V_segment       79..358
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <352..>402
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65177.1"
                     /translation="CAIGPSGNWNGWSFDVW"
     D_segment       366..381
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       384..433
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>435
                     /gene="IGHG"
BASE COUNT           90 a          119 c          134 g           92 t
ORIGIN      
        1 acatggggac agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca
       61 gctacaggcg cccactctga ggtccttctg gtgcagtctg ggactgaggt gatgcagcct
      121 ggggcctcag tgaaggtctc ctgcaaggtt tccggataca ccttcaccga actgtccatg
      181 cactgggtgc gacaggcccc tggaaaaggg cttgagtggg tgggaagtgt tgatcctgca
      241 tatggtgaaa tggtgttcca gggcagagtc accatgaccg aggacacgtc tatagacaca
      301 gcctatatgg agttgagcag cctgagatct gaggacacgg ccgtgtatta ctgcgcgatt
      361 ggccctagcg gcaactggaa cggctggtcc ttcgatgtct ggggacctgg caccccaatc
      421 accatctcct cagcc
//
LOCUS       KCXD01006696             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:16386:18018
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006696
VERSION     KCXD01006696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:16386:18018"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..501
     V_segment       141..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65178.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       434..449
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          123 c          159 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcact ggaagtccac agtgttccat tcggtgatca
       61 gcactgaaca cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagg tggtggagtc tgggggcggc ttggcaaagc
      181 ctgggggatc cctgagactc tcctgtgcag cctctggatt caccttcagt acctatgcta
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagcc attagtgttg
      301 gtggtagtac atattacgca gactccgtga ggggccgatt caccatctcc agagacaact
      361 cagagaacac gctctccctg caaatgaaca gcctgagagc tgaggacacg gccgtgtatt
      421 actgtgcgaa aggggataca gctacagttt attacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006697             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17727:16744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006697
VERSION     KCXD01006697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17727:16744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65179.1"
                     /translation="CARYPYSGSYFRYFDYW"
     D_segment       398..412
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          137 c          133 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggcgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat attagtatta gtgggaggac cgactacaac ccctccctca agagtcgagt
      301 caccatctca acagacacgt ccaagaacca gttctccctg aagttgacct ctgtgaccgt
      361 cgcggacacg gccgtgtatt actgtgcgag atatccatat agtgggagct acttcaggta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006698             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12913:3722
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006698
VERSION     KCXD01006698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12913:3722"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65180.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       431..437
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          138 c          140 g          101 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaggt acaggcgccc
      121 actctgaggt ccagctggtg cagtcggggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctgttttt ggtgaaataa
      301 tgaattcaga gaagttccag ggcagagtcg ccttgaccga ggacacgtct acagacacag
      361 cctacatgga gttgagcagc ctgagatctg aggacacggc cgtgtattac tgtgcgacat
      421 catccagcgg cacctggcta tattggtact tcgatgtctg gggccctggc accccaatca
      481 ccatctcctc agcc
//
LOCUS       KCXD01006699             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24163:12493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006699
VERSION     KCXD01006699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24163:12493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65181.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          111 a          142 c          135 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattattgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01006700             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5929:14301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006700
VERSION     KCXD01006700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5929:14301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    148..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        148..523
     V_segment       148..440
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <439..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65182.1"
                     /translation="CTTWRYYYSTGYPTFDYW"
     D_segment       454..465
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       480..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          123 a          128 c          149 g          125 t
ORIGIN      
        1 acatgggggc agctctggga gaggagaccc agccttggga tttccagctg tctccagttg
       61 gcgatcagca ctgaacacag gagactcgcc atggagtttg tactgagctg ggttttcctt
      121 gttgctatat taaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg
      181 gtccagcctg gcgggtccct gaaactctcc tgtgcagcct ctggattcac cttcagtgac
      241 tttgccatga actgggtccg ccaggcttct gggaaaggac tggagtgggt tggctatatt
      301 agaaccaaat ataacaatta cgcgacagaa tacgccgcat cggtgaaagg caggttcacc
      361 atctccagag atgattcaaa gaacacgata tatctgcaaa tgagcagcct gaaaaccgag
      421 gacacggccg tgtattactg caccacatgg agatattact atagtactgg ttaccccacc
      481 tttgactact ggggccaggg agtcctggtc tccgtctcct cagcc
//
LOCUS       KCXD01006701             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:10120:17863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006701
VERSION     KCXD01006701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:10120:17863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65183.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          114 c          149 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006702             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:25175:3587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006702
VERSION     KCXD01006702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:25175:3587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..484
     V_segment       118..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65184.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       426..431
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          114 a          146 c          136 g           90 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccgctctgag
      121 gtccagctgg tgcagtccgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacac cttcaccgaa ttctccacgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggaggtgtt gatcctgcat atggtgaaat gacacacgca
      301 gaaaacttcc agggcagact caccatgacc gaggacacgt ctacagacac ggcctacatg
      361 gagctgagca gcctgagatc tgaggacacg gccgtgtatt attgtgcgag atcatccagc
      421 ggtacgtggc tatactggta cttcgatacc tggggccctg gcaccccaat caccatctcc
      481 tcagcc
//
LOCUS       KCXD01006703             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:26500:16276
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006703
VERSION     KCXD01006703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:26500:16276"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65185.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       435..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          123 c          157 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg gggcggcttg gcgaagcctg
      181 ggggatccct gagactcttc tgtgcagcct ctggatttac cttcaatacc tattctatac
      241 actgggtccg ccaggctccc gggaaggggc tggagtgggt ctcagccatt agtagtggtg
      301 gtagaacata ctacgcagac tccgtgaagg gccgagtcac catctccaga gacaactcaa
      361 agaacacagt ctccctgcaa atgaacagcc tgggagctga ggacacggcc gtgttttact
      421 gtgcgagagg ggagacagct tcagtttact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006704             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:16201:2543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006704
VERSION     KCXD01006704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:16201:2543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65186.1"
                     /translation="CARADRGSSIDFW"
     D_segment       441..447
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          114 a          115 c          148 g          119 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaagactca ccatgaagtt tgggctgagc tgggttttcc ttgttgcaat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctaagactct cctgtgcagc ctctggattc accttcagta cctatggcat
      241 gcactgggtc cgccaggctc cagggcaggg gctggagtgg gtggcggtta tatcttatga
      301 tgatgataag aaatactaca cagactcttt gaaggaccga ttcaccatat ccagagacaa
      361 ttccaagaac actctttatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      421 ttattgtgcg agagcggatc gcggcagttc aattgacttc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006705             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:17277:11151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006705
VERSION     KCXD01006705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:17277:11151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65187.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          113 c          151 g          123 t
ORIGIN      
        1 acatggggag ttctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggcgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgtcag gctccaggaa aggggctgga gtgggtggca gttatctcgt
      301 ctgatggaag ttacaaatac tacgaagact ctttgaagga ccgattcacc atctccagag
      361 acaattccag gaacatgcaa tatcttcaga tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01006706             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8941:5519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006706
VERSION     KCXD01006706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8941:5519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    129..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        129..501
     V_segment       129..422
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <414..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65188.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       439..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          120 c          153 g          126 t
ORIGIN      
        1 acatggggag gagtcttagc cctggattcc aagaacttcc actttgggat cagctctgaa
       61 cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt ttaaaaggtg
      121 tccagtgtga ggtggagctg gtggagtctg ggggaggctt ggtccagcct ggggggtccc
      181 tgagactctc ctgtgtagcc tctggattca cctttggtga ttatggcatg cactgggtcc
      241 gccaggctcc gggaaaggga ctggagtggg tctcatccat tagaaacact ggtaaaatcg
      301 tatactacgc tgactccgtg aagggccgat tcatcatctc cagagacaac gccaagaatt
      361 cgctgtctct gcaaatgagc agcctgagag tcgaggactc ggccgtctat tactgtacta
      421 gaattggcgt cggatctcta gcaccggctg gtgaatactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006707             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:2944:13937
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006707
VERSION     KCXD01006707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:2944:13937"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..280
     V_segment       8..193
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <187..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65189.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       207..220
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..280
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>282
                     /gene="IGHG"
BASE COUNT           66 a           71 c           90 g           55 t
ORIGIN      
        1 acatgggggg tacgacaggc ccctgggaaa gggcttgagt ggatgggagt tgttgatcct
       61 gtcaatggtg aagaaataca cgcagagaag ttccagggca gagtcaccat gaccgaggac
      121 acgtggacag acacagccta catggacttg accagtctca gatctgagga cacggccatc
      181 tattactgtg cgacagggag gatcggtagc agcggctggt ccaacctctt caccggtttg
      241 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006708             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:13414:16816
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006708
VERSION     KCXD01006708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:13414:16816"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..506
     V_segment       134..427
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65190.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       444..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          121 c          156 g          126 t
ORIGIN      
        1 acatggggga gacaggagtc ttagccctgg attccaagaa cttccacttt gggatcagct
       61 ctgaacacag aggaccatgg agttggggct gagctgggtt ttccttgttg ctattttaaa
      121 aggtgtccag tgtgaggtgg agctggtgga gtctggggga ggcttggtcc agcctggggg
      181 gtccctgaga ctctcctgtg tagcctctgg attcaccttt ggtgattatg gcatgcactg
      241 ggtccgccag gctccgggaa agggactgga gtgggtctca tccattagaa acactggtaa
      301 gatcgtatac tacgctgact ccgtgaaggg ccgattcatc atctccagag acaacgccaa
      361 gaattcgctg tctctgcaaa tgagcagcct gagagtcgag gactcggccg tctattactg
      421 tactagaatt ggcgtcggat ctctagcacc ggctggtgaa tactttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006709             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18862:19303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006709
VERSION     KCXD01006709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18862:19303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65191.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccat tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatgcactg ggtccgccag gctccaggga agggtctgga gtgggtggca gttatgtcgc
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccaggg
      361 acaattacaa gaacatggta tatcttcaaa tgaacaacct gagattggag gacgcggccg
      421 tctattattg tgcgagagga gactacggta acagccttga cttctggggc cagggagtcc
      481 tgctcaccgt ctcctcagcc
//
LOCUS       KCXD01006710             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21297:4902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006710
VERSION     KCXD01006710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21297:4902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65192.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          115 a          144 c          129 g           93 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctacact gggtgcgaca
      241 ggctcctgga aaaggacctg attggatggg aggtattcac cctgagtatg gtaaagtaga
      301 ctacacacag aagttccgag acagagtcac catcatcgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctagtcgccg tctcctcagc
      481 c
//
LOCUS       KCXD01006711             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18344:14763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006711
VERSION     KCXD01006711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18344:14763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65193.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          128 c          140 g          110 t
ORIGIN      
        1 acatggggga cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg atttaccttc gacaaatatg gaatcaactg ggtgcggcag
      241 gcccctggac aagggcttga gtggatggga gtggtcatcc cccttgttgg tattatcaat
      301 tatgcagaga acttccaggg cagaataatg attaacgcgg acacgtccat aaacacagcc
      361 ttcatggagt tcaggagcct gagatctgac gacacggcca tttatttctg tgcgagagaa
      421 tactgtacaa ctactgattg cgccgggttc tttgactact ggggccaggg agtcacggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006712             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21855:13737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006712
VERSION     KCXD01006712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21855:13737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..401
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <393..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65194.1"
                     /translation="CARVTGIAAAGTFFFDHW"
     D_segment       408..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT           92 a          137 c          138 g          112 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcgt ctcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc ggtgtctctg
      181 gtggctctat cagcagttat aactggtgga gttggattcg ccagtcccca gggaaaggac
      241 tggagtggat tgggtttatc ggtggtggta gtgatagtac ctcctatagc ccctccctca
      301 agagtcgagt caccatttca acagacaggt ccaagaacca gttctccctg aaactgacct
      361 ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgcg agtcaccggt atagcggcag
      421 ctggcacgtt cttctttgac cactggggcc agggactcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006713             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19890:10039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006713
VERSION     KCXD01006713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19890:10039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65195.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       451..458
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..500
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          122 c          157 g          117 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagtt ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat
      241 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      301 tggggatagc acctactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgacgaca cggctgtcta
      421 ttactgtgcg agagtggtgg gtggtgccgc aggatatttc gacttctggg gccagggcgc
      481 actggtcacc gtctcctcag cc
//
LOCUS       KCXD01006714             280 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:23259:7428
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006714
VERSION     KCXD01006714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 280)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 280)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:23259:7428"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..278
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..278
     V_segment       9..211
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <203..>247
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65196.1"
                     /translation="CARVRGVTIYYFDYW"
     D_segment       221..228
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       233..278
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        279..>280
                     /gene="IGHG"
BASE COUNT           55 a           84 c           82 g           59 t
ORIGIN      
        1 acatgggggt tactcctgga gctggatccg ccagccccca ggcaagggtc tggagtggat
       61 tggacatgtc agtggtagta gtgggagcac cgactacaac ccctccctca agagtcgagt
      121 caccatttca acagacacgt ccaagcgcca gttctccctg aggctgattt ctgtgaccgc
      181 cgcggacacg gccgtctatc attgtgcgag agtccggggc gtgactatct attactttga
      241 ctactggggc cagggagccc tggtcaccgt cgcctcagcc
//
LOCUS       KCXD01006715             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12753:11120
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006715
VERSION     KCXD01006715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12753:11120"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..391
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65197.1"
                     /translation="CAGRTWSGGTPLLDYW"
     D_segment       424..431
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          135 c          134 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tggaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggttt
      181 ctccatcagc agtgactact ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atatatggaa gaagtgggag catctactat aatccctccc tcaacagtcg
      301 agtcaccttt tcaacagaca cgtccaagaa ccagttctcc ttgaagctga actctgtgac
      361 cgccgcagac gcggccgttt attactgtgc ggggcggacc tggagtggtg gcacgcccct
      421 ccttgattat tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006716             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:8038:8274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006716
VERSION     KCXD01006716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:8038:8274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65198.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       416..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          119 a          140 c          133 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag gagcctgggg cctcagcgaa
      181 ggtctcctgc aagtttttcg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 acacacagag ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctaa gatctgagga cacggccctg tattattgtg cagtcgggta
      421 tagcggccga tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01006717             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:18339:17465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006717
VERSION     KCXD01006717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:18339:17465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..502
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65199.1"
                     /translation="CARGGFGTSVWSNLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>506
                     /gene="IGHG"
BASE COUNT          116 a          141 c          151 g           98 t
ORIGIN      
        1 acatggggga gcaccacaca acaaccacat ccctcgccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaagt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtcgcctg caaggtttcc ggaaacacct tcaccgaatt attcatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgtcga tcctgctcaa ggtgaaataa
      301 tatacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 ccttcatgga gttgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgagag
      421 gggggttcgg aaccagcgtc tggtccaacc tcttctacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tctgcc
//
LOCUS       KCXD01006718             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:15756:8242
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006718
VERSION     KCXD01006718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:15756:8242"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65200.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          116 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gttcgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aagaaatact acgcaaactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atatggggac cggttttgac tactggggcc agggagtcct
      481 ggtcatcgtc tcctcagcc
//
LOCUS       KCXD01006719             446 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14630:15095
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006719
VERSION     KCXD01006719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14630:15095"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    90..444
                     /note="immunoglobulin heavy chain variable region"
     V_region        90..444
     V_segment       90..383
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <375..>413
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65201.1"
                     /translation="CVRDAFGSGFDVW"
     D_segment       389..394
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..444
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        445..>446
                     /gene="IGHG"
BASE COUNT           98 a           96 c          142 g          110 t
ORIGIN      
        1 acatggggag cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc
       61 ttgttgctat tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct
      121 tggttcagcc tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta
      181 cctatggcat acactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtga
      241 tatcgtatga tgaaaataag aagtactacg cagactctgt gaagggccga ttcaccgtct
      301 ccagagacaa ttccaagaat atgatatatg ttcaaatgaa caacctgaaa ttggaggaca
      361 cggccgtgta tttctgtgtg agagatgcat ttgggtcggg gttcgatgtc tggggcccgg
      421 gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01006720             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:9573:4236
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006720
VERSION     KCXD01006720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:9573:4236"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..437
     V_segment       87..380
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65202.1"
                     /translation="CVRDAFGSGFDVW"
     D_segment       386..391
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       397..437
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>443
                     /gene="IGHG"
BASE COUNT           96 a           97 c          139 g          111 t
ORIGIN      
        1 acatgggcac agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg
       61 ttgctatttt aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg
      121 ttcagcctgg ggggtccctg agactctcct gtgcggcctc tggattcacc ttcagtccct
      181 atggcataca ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagtgatat
      241 cgtatgatga aaataagaaa tacttcgcag actctgtgaa gggccgattc accatctcca
      301 gagacaattc caagaatatg atttatgttc aaatgaacaa cctgaaattg gaggacacgg
      361 ccgtatattt ctgtgtgaga gatgcatttg ggtcggggtt cgatgtctgg ggcccgggag
      421 tcctggtcgc cgtctccgca gcc
//
LOCUS       KCXD01006721             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8690:10370
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006721
VERSION     KCXD01006721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8690:10370"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..448
     V_segment       85..378
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65203.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       388..394
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..448
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           91 a          107 c          142 g          110 t
ORIGIN      
        1 acatgggcac taaacacaga acataccatg gagtttgtgc tgagctgggt tttccttgtt
       61 gctcttttga aaggtgtcca gtgtgaggtg cagctggtgg agtcgggggg cggcttggca
      121 aagcctgggg ggtccctgag actctcctgc gcagcctctg gattcagctt cagttactac
      181 ttcatgagct gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaat
      241 agtggtgggg atgatacata ctatgcagac tccgtgaagg gccgattcac cttgtccaga
      301 gagaacgcca agaacacact gtatcttcac atggtcagcc tgagaggtga ggacacggct
      361 gtctattact gtgcgagaga ccgacgtgta cagtcgttat cctggttcga tgtctggggc
      421 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006722             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:18788:15784
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006722
VERSION     KCXD01006722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:18788:15784"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65204.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       434..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          115 c          155 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcatctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagttcc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggactgggt ggcagttatg tcgtctgatg
      301 gaagtaacaa gtactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtttatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag agatgtcttt ggcggggggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006723             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13742:13478
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006723
VERSION     KCXD01006723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13742:13478"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65205.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       268..273
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       274..319
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           75 a           79 c           92 g           75 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtaaaatcg
      121 tttgatggaa ctaagatata ctacgcagac tctgtgaagg accgattcac catctccaga
      181 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtttattact gtgtgagaga tgcctacggg agcggtttgg attcctgggg ccaaggggtc
      301 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006724             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14551:5464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006724
VERSION     KCXD01006724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14551:5464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65206.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          115 c          151 g          121 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaagtttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaagct ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatctgcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatcttggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006725             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8326:9641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006725
VERSION     KCXD01006725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8326:9641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..472
     V_segment       115..407
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65207.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       413..418
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..472
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          110 a          106 c          141 g          117 t
ORIGIN      
        1 acatggggga ccacagtgtt ccattcggtg atcagcacag aacacagagg actcaccatg
       61 aagtttgggc tgagctgggt tttccttgtt gctattttaa gaggtgtcca gtgtgaggtg
      121 cagctggtgg agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt
      181 gcagcctctg gattcacgtt cagtaactat ggaatgcact gggtccgcca ggctccaggg
      241 aaggggctgg agtgggtggc agttatatcg tacgatgaag ataagaaata ctacgcagac
      301 tctctgaagg accgattcac catctccaga gacaattcca agaacatgct ttatcttcaa
      361 atgaacaacc tgaaattgga ggacacggcc gtttattact gtgcgaggag gccctggagt
      421 gcagatgctt ttgatttctg gggccaagga ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01006726             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24672:11756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006726
VERSION     KCXD01006726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24672:11756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65208.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       447..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          116 a          113 c          153 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cacctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gaagcctctg gattcacctt cagtagttat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgtaa gtaagaaata ctacgcagac gctgtgaatg accgattcac catctccaga
      361 gacaattcca agaacaccct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgggagaga tgataatggg gtgcttatcg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006727             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:22737:19330
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006727
VERSION     KCXD01006727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:22737:19330"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65209.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          113 c          149 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcttcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaaataacaa atactacgca gactctgtga aggaccgatt caccatttct agagacaatt
      361 ccatgaacat gctatttctt caaatgaaca acctgaactt ggacgacacg gccgtctatt
      421 attgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006728             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:13387:8635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006728
VERSION     KCXD01006728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:13387:8635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..475
     V_segment       101..408
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65210.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       415..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>481
                     /gene="IGHG"
BASE COUNT           84 a          145 c          139 g          113 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc agtaccaact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggctgt atctttggtg gtggtatctt tggtggtgga agtaacacct actacagccc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aaggcccagc tctccctgaa
      361 gctgacgtct gtgaccaccg cggacacggc cgtctatttc tgtgcgagcg ctgatagtgg
      421 ttatcctccc tacttctttg acatctgggg ccagggagtc ctggtcaccg tctccccagc
      481 c
//
LOCUS       KCXD01006729             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:12356:20507
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006729
VERSION     KCXD01006729.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:12356:20507"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..429
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65211.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       432..456
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..512
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          104 a          127 c          157 g          126 t
ORIGIN      
        1 acatggggtc tgagacagga gccttagccc tggattccaa gaacttccac tttgggatca
       61 gctctgaaca cagaggacca tggagttggg gctgagctgg gttttccttg ttgctatttt
      121 aaaaggtgtc cagtctgagg tgcagctggt ggagtctggg ggaggcttgg tccagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcagc tttggcgatc atggcatgca
      241 ctgggtccgc caggctccgg gaaagggact ggagtgggtc tcatctatca gtaatactgg
      301 taaagccgta cactacgctg actccgtgaa gggccgattc accatctcca gagacaacgc
      361 caagaactcg ctgtctctgc aaatgagcag cctgagagcc gaggacacgg ccgtgtatta
      421 ctgttctagc gattactata gtggtagtta ttactattgg ggctacggct tggattcctg
      481 gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006730             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22680:14958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006730
VERSION     KCXD01006730.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22680:14958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65212.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          137 c          129 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agagcatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggccctgt cccaggtgct tctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaaccccgc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006731             528 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7731:10312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006731
VERSION     KCXD01006731.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 528)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 528)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7731:10312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..526
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..526
     V_segment       145..438
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>495
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65213.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       448..454
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..526
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        527..>528
                     /gene="IGHG"
BASE COUNT          111 a          119 c          161 g          137 t
ORIGIN      
        1 acatgggggc tctgggagag gagccacagc cccgggattc ccagctgtct ccacttggtc
       61 atgaacactg aactcagaag acgcaccatg gagtttgtgc tgagtttgct tttccttgtt
      121 gcttttttaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggta
      181 aagcctgggg ggtccctgag actctcttgt gtagtctctg gattctcctt cagtaactat
      241 gttatgcatt gggtccgcca ggctccagga aagggtctgg agtgggtctc acttattagt
      301 ggaagtggtg gtaccacaga ctacgcagac tctgtgaagg gccgattcac cctctccaga
      361 gacaacgcca aggaatcgct ttttctgcaa atgaacagcc taagagccga ggacacggcc
      421 gtgtattact gtgctagagg cggggaaata gtggattcag agattattga ggattactac
      481 ggtttggatt tctggggcca aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01006732             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22401:17738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006732
VERSION     KCXD01006732.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22401:17738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65214.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          112 a          143 c          129 g           91 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggacttg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaggct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatggtaaag tggactacac
      301 acagaagttc cgagacagac tcaccatcac cgcggacatg tcgacagaga cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgactact ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006733             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:14767:12337
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006733
VERSION     KCXD01006733.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:14767:12337"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65215.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       423..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          119 a          144 c          132 g           97 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg attcaccttt accgatttat ccatacactg gatacgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggaat tgagcagcct gaaatctgac gacacggccg tatattactg tgcgagtggc
      421 cctagcggca cctggatcga ctggtccttc gatgtctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01006734             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15611:14978
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006734
VERSION     KCXD01006734.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15611:14978"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65216.1"
                     /translation="CARVVGGAAGYLDFW"
     D_segment       437..443
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          107 a          127 c          158 g          113 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggggat agcacctacc atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccagg aacacactgt atcttcaaat ggacagcctg agagctgacg acacggctgt
      421 ctattactgt gcgagagtgg taggtggtgc cgcaggatac ctcgacttct ggggccaggg
      481 cgcactggtc accgtctcct cagcc
//
LOCUS       KCXD01006735             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15740:14051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006735
VERSION     KCXD01006735.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15740:14051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65217.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       431..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          116 a          132 c          148 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagt tacaggcgcc
      121 cactctgagg tccagttggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgatt tatccatgca ctgggtgcga
      241 caggccccag gaaaagggct tgagtggatg ggaagtgttg atcctgtata tggtgaaata
      301 attgtcgcag agaatttcca ggacagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctggaatct gaggacacgg ccgtgtatta ctgtgcgaaa
      421 gggaggagtg gtggtgtctg gccgagctcc ttcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006736             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:9735:12839
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006736
VERSION     KCXD01006736.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:9735:12839"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..484
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65218.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>488
                     /gene="IGHG"
BASE COUNT          119 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcgaggt ttccggatac atcttaaccg aattatccat acactgggtg cgacaggccc
      241 ctggaaaagg gcttgaatgg atgggaagtg ttgatcctca atatggtgaa atgatagacg
      301 cagagaaatt ccagggcaga gtcaccctga ccgaggacac gtctacagac acagcctaca
      361 tggaactgag cagtctgaga tctgaggaca cggccgtgta ttactgtgcg acatcatcca
      421 gcggcacctg gctatactgg tacttcgatt tctggggccc tggcacccca atcaccatct
      481 cctccgcc
//
LOCUS       KCXD01006737             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20506:15850
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006737
VERSION     KCXD01006737.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20506:15850"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65219.1"
                     /translation="CSRWGTPFDYW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           90 a          133 c          130 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtag
      181 ctccatcaac agtggttatg cctggagctg gatccgccag cccccaggga aggggctgga
      241 gtgggttggg catatctatg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagt tgaattctgt
      361 gaccgccgcg gacacggccg tgtattactg ttcgagatgg gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006738             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15090:8681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006738
VERSION     KCXD01006738.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15090:8681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65220.1"
                     /translation="CARDSSWYNWNQDFDYW"
     D_segment       407..420
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          101 a          136 c          132 g          102 t
ORIGIN      
        1 acatggggat gttctctgag actcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctga cccagctgca gcttcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcaaatgcgc tgtctctggt
      181 ggctccatca ccggtaacta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtagcactga tagtggtggg agtactgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gagctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagata gtagttggta taattggaac
      421 caagactttg actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006739             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11981:20331
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006739
VERSION     KCXD01006739.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11981:20331"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..492
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65221.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       418..424
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          139 c          144 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctccag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca cctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa agtttccgga tacaccttca ccgatttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatac tgtatctgat ggagtgatat
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gcgagaggtg
      421 tgacagcaga cgtcttcggt ttcctcgggc ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006740             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19007:19950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006740
VERSION     KCXD01006740.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19007:19950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65222.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       410..418
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           95 a          131 c          140 g          104 t
ORIGIN      
        1 acatggggga atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggactggtg aagcctccgg agaccctgtc tctcacctgc ggtgtctctg
      181 gtggctctat cagcagtagt tactgcagct ggatccgcca gaccccaggg aagggactgg
      241 agtggattgg gtatatctat gggagggata gtagtaccaa gtacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtg ctccctgaag ctgagctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagttc gggtatagaa gtggttgcct
      421 acagcattga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006741             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13700:15783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006741
VERSION     KCXD01006741.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13700:15783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..489
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65223.1"
                     /translation="CARGPNYEDDNGYQTAFDSW"
     D_segment       415..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          137 c          137 g          102 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtacccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc aatatctatg ccatcacttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcatcc ctcttgttga tataacaaac tacgcacaga
      301 agttccaggg cagagtaacg attaccgcgg atacgtccac aagcacagcc tacatggaac
      361 tgaacagcct gagatctgag gacacggccg tgtattactg tgcgagaggt cctaattacg
      421 aggatgataa cggttaccag accgcttttg actcctgggg cccgggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006742             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17000:15773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006742
VERSION     KCXD01006742.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17000:15773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..481
     V_segment       118..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65224.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       409..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          117 a          139 c          132 g           95 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcata gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccaggtgg tgcagtctgg ggctgaggtg aaggagcctg gggcctcagc gaaggtctcc
      181 tgcaaggttt ccggatacac cttcaccgaa ttatccatgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggaagtgtt gatcctctat atggtgaaat gaaacacaca
      301 gagttccatg ccagattcac catgaccgag gacacgtcta cagacacagc ctacatggag
      361 ttgagcagcc taagatctga ggacacggcc ctgtattatt gtgcagtcgg gtatagcggc
      421 cgatggaaca actggtactt cgatctctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01006743             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13996:14464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006743
VERSION     KCXD01006743.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13996:14464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..450
     V_segment       84..380
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65225.1"
                     /translation="CARKLPGLQLTGLDSW"
     D_segment       395..401
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       404..450
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           90 a          135 c          129 g           98 t
ORIGIN      
        1 acatgggggc catcctgtgc aagaacatga agcacctgtg gttcttcctc ctcctggtgg
       61 cagctcccag aagggtcctg tcccaggtgc agctgcagga gtcgggccca ggactggtga
      121 agccttcgga gaccctgtcc ctcacctgcg gtgtttctgg tgactccatc aagagtggct
      181 actactggag ctgggtccgc caacccccag ggaaggggct acagtggatt gggtttatcg
      241 gtggtagtag tggtagcacc tacgtcaact cctccctcaa gagtcgagcc accctttcaa
      301 aagacacgtc caggaaccag ttctccctga aactgaactc tgtgaccgcc gcggacacgg
      361 ccgtgtatta ctgtgcgaga aaacttccag gtctgcaact aaccggtttg gattcctggg
      421 gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006744             392 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:11526:3107
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006744
VERSION     KCXD01006744.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 392)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 392)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:11526:3107"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..390
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..390
     V_segment       145..318
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <312..>359
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65226.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       335..345
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       347..390
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        391..>392
                     /gene="IGHG"
BASE COUNT           71 a          131 c           97 g           93 t
ORIGIN      
        1 acatggggct ccctcaccac ccagctgggg atctcagtgc ttcattttct gtccttcatt
       61 tctcagtgct tcatttctgt cctccaccac gatggggtca actgccatcc tcgccctcct
      121 cctggctgtt ctccaaggag tctgtgcccg ggaaaggcct ggagtggatg ggaatgatct
      181 atcctagtga ttctgatccc agatacagcc cgtccttcca aggccaggtc accatctcag
      241 ccgacaggtc catcagcacc gcctacctgg agtggggcag cctgaaggcc tcggacaccg
      301 ccacgtatta ctgtgcgaga gctggacgct acacctacag ttaccccttt gactactggg
      361 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006745             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11114:12153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006745
VERSION     KCXD01006745.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11114:12153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65227.1"
                     /translation="CARDAYGTGFDFW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          120 c          153 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attctccctc agtagatttg
      241 gcattcactg ggtccgccag actccaggga aggggctgga gtgggtgaca gttgtctcgt
      301 ctgatggaac taagacatac tacgcagact ctgtgaagga ccgattcact atctccgggg
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgcgagac gcctacggta ccggctttga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006746             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22540:11509
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006746
VERSION     KCXD01006746.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22540:11509"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..514
     V_segment       139..431
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65228.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       434..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          104 a          128 c          158 g          126 t
ORIGIN      
        1 acatgggggc tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtctga ggtgcagctg gtggagtctg ggggaggctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gctttggcga tcatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatctat cagtaatact
      301 ggtaaagccg tacactacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaact cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtgtat
      421 tactgttcta gcgattacta tagtggtagt tattactatt ggggctacgg cttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01006747             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12906:5550
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006747
VERSION     KCXD01006747.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12906:5550"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65229.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       403..410
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           82 a          138 c          132 g          114 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcgattact tctggaactg ggtccgccag tccccaggga gggggctgga
      241 gtggattgga tttttctatg gtgctactgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc ttttcagcag acacgtccca gaaccagttt tccctgaggc tgacctctgt
      361 gaccgccgcg gacaccgccg tttattattg tgcgagatat cagggtgatt ccttgtacta
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006748             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20905:2467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006748
VERSION     KCXD01006748.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20905:2467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65230.1"
                     /translation="CVRDSSGSGFDRW"
     D_segment       443..448
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          112 c          153 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catacactgg gtccgcctgg ctccagggaa ggggctgggg tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact atggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcacat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatt caagcggttc gggatttgac cgttggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006749             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:19163:16367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006749
VERSION     KCXD01006749.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:19163:16367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65231.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          102 a          125 c          161 g          119 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gcctctggat tcagtttcag tcactacttc
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg gattaacagt
      301 ggtggggata ctacatacca cgcagactcc gtgaagggca gattcaccat gtccagagag
      361 aacgccagga acacactgtc tcttcaaatg gacggcctga gagctgagga ctcggctgtc
      421 tattactgtg cgagagatcg acgtgtacag tcgttatctt ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006750             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16837:22936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006750
VERSION     KCXD01006750.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16837:22936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..488
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65232.1"
                     /translation="CAREFSPYDYSWSDFYSYYFDYL"
     D_segment       432..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           96 a          149 c          132 g          113 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca cgactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcggctact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg catatcagtg ggagtagtgg gagcaccgac tacaacccct ccctcaaaag
      301 tcgagtcacc atttcaacag acacgtccaa gagccacttc tccctgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagag ttttccccct acgactattc
      421 ttggagtgat ttttactctt actactttga ctacttgggc cagggactcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01006751             352 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15073:17769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006751
VERSION     KCXD01006751.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 352)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 352)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15073:17769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..350
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..350
     V_segment       8..274
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <263..>319
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65233.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       279..295
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       304..350
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        351..>352
                     /gene="IGHG"
BASE COUNT           84 a          102 c           89 g           77 t
ORIGIN      
        1 acatggggtg aaacccacac agaccctcac gctgacctgc accttctctg ggttctcaat
       61 cagtacttct gcaacaggtg tgggctggat ccgtcagccc ccagggaagg ccctggaatg
      121 gcttgcaagc atttattgga atgatactaa attcttcagc acttcgctga agagcagact
      181 caccgtctcc aaggacacct ccaaaaccca ggtggttcta acaatagcca acatggaccc
      241 tgtggacaca gccacatatt actgtgcacg gatacagggt ggtagttact actacggtgg
      301 gggatacttc gagttctggg gccagggcgc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006752             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16475:4466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006752
VERSION     KCXD01006752.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16475:4466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65234.1"
                     /translation="CVRYEDESINYHFDCW"
     D_segment       397..404
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           94 a          134 c          129 g          108 t
ORIGIN      
        1 acatggggct ctctgagagt catggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaagtc ttcggagacc ctgtccctca cctgcggtgt ctctggtgac
      181 tccatcagca atagctactg gaactggatc cgccagcccc cagggaaggg actggagtgg
      241 attgggtata tctctggtgc ttatgggagc accagctaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cagttttccc tgaggctgag ttctgtgacc
      361 gccgcggaca ccgccgtgta ttattgtgtg agatatgagg atgaatccat taactaccac
      421 tttgactgct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006753             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:21838:8140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006753
VERSION     KCXD01006753.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:21838:8140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65235.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       411..415
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          141 c          132 g          101 t
ORIGIN      
        1 acatggggga ggttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggcgccatc agcagtggtt tctactggac ctggatccgc caacccccag ggaaggggct
      241 ggagtggatt gggtgtatcg gtggtaatag tggtaccacc tactaccacc cctccctcaa
      301 gagtcgagcc accatttcaa aagacacgtc cagcaatcaa ctctccctga agctgagttc
      361 tgtgaccgcc gcggacacgg ccgtgtatta ctgtgcgaga gatgaagacc cctccatttt
      421 tgactactgg ggccagggcg tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006754             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18772:13495
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006754
VERSION     KCXD01006754.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18772:13495"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..450
     V_segment       84..377
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <369..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65236.1"
                     /translation="CARYEGAAAGTWYFDYW"
     D_segment       387..400
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           83 a          135 c          133 g          101 t
ORIGIN      
        1 acatggggga cctcctgtgc aagaacatga agcacctgtg gttcttcctt ctcctggtgg
       61 cagctcccag atgggtcctg tcccaggtgc aactgcagga gtcgggccca ggactggtga
      121 agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccgtc agcaattcct
      181 tctggagctg gatccgccag cccccaggga agggcctgga gtggattgga tatatctatg
      241 gtagtagtgg gagcaccggc tacaatccct ccctccaggg tcgagtcacc atttcaacag
      301 acacgtccaa caaccaggtt tccctgaagc tgagctctgt gaccgccgcg gacaccgccg
      361 tgtttttttg tgcgagatat gagggggcgg cagctggaac ctggtacttt gactactggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006755             549 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17736:12301
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006755
VERSION     KCXD01006755.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 549)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 549)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17736:12301"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    169..547
                     /note="immunoglobulin heavy chain variable region"
     V_region        169..547
     V_segment       169..460
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <454..>516
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65237.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       475..487
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       498..547
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        548..>549
                     /gene="IGHG"
BASE COUNT          125 a          151 c          163 g          110 t
ORIGIN      
        1 acatggggac tggtgtctgc cgaggtaaat acagatctgt ccttgtccag agagcatcac
       61 acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac catggactgg
      121 acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga ggtccagctg
      181 gtgcagtctg gggctgaggt gaagaagcct ggggcctcag taaaggtctc ctgccaggtt
      241 tccggataca ccttcagtga aatgtccatg cactgggtgc gacaggcccc tggaaaaggg
      301 cttgagtgga tgggatgtgt tgctcctgga aatggtgaaa taatacacgc agagaacttc
      361 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggagctgagt
      421 agcctgagat ctgaggacac ggccgtgtat tactgtgcga cagggaggtt cgggagcagc
      481 gtctggtcca gcctcttcta cggtttggat tcctggggcc aaggggtcgt cgtcaccgtc
      541 tcctcagcc
//
LOCUS       KCXD01006756             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10076:6206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006756
VERSION     KCXD01006756.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10076:6206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..501
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65238.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       441..447
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          124 c          157 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagccgg
      181 gggggtccct gagactctcc tgcgcagtct ctggattcag tttcagtcac tacttcatga
      241 gctgggtccg ccagactcca gggaagggac tggagtggat ctcagtgatt aacagtggtg
      301 gagataccac acactatgca gactccgtga agggcagatt caccatgtcc agagagaacg
      361 ccaggaacac actgtctctt caaatggacg gcctgagacc tgaggactcg gctgtctatt
      421 actgtgcgag agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006757             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:19461:16668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006757
VERSION     KCXD01006757.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:19461:16668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65239.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          112 c          150 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaacaaagaa atactacgca gactctctga aggaccgctt catcatctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaata acctgaaatt ggatgacacg gccgtatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgacttctg gggccagggt gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006758             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14240:6217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006758
VERSION     KCXD01006758.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14240:6217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65240.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          115 c          150 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgcgagggag gagagatttg gctacagttt tgacttctgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006759             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8372:11451
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006759
VERSION     KCXD01006759.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8372:11451"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65241.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       438..443
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          117 a          111 c          149 g          114 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccaatcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtacctat ggcatacact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg tatgatgaaa
      301 ctaagaaata ctacgcagac tctgtgaggg accgattcac catctccaga gacaattcca
      361 aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc gtatattact
      421 gtgtgagaga tgtcagggga acggggtttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01006760             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18278:15287
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006760
VERSION     KCXD01006760.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18278:15287"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65242.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           96 a          146 c          146 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagtaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006761             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:27525:16876
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006761
VERSION     KCXD01006761.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:27525:16876"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..509
     V_segment       134..423
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65243.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       461..467
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..509
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          111 a          122 c          158 g          120 t
ORIGIN      
        1 acatggggag aggagcccag ccccagaatt cccaggtatt tctgttcggc gatcagcact
       61 aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg ctcttttgaa
      121 aggtgtccag tgtgaggtgc acctggtgca gtctgggggc ggcttgacaa agccgggggg
      181 gtccctgaga ctctcctgtg cagcctccgg attcaccttc agtgactact atatggactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtctca cgaatcggtc atgatggtgg
      301 tagcacatgg tacgcagact ccgtgaaggg cagatttacc atttccagag agaatgccaa
      361 gaacacactg tttcttcaaa tggacagcct gagaagtgag gacacagccg tatattactg
      421 tgccagagag cggtttgggg gaattggggt aattatcttc aactggatcg atgtctgggg
      481 cccgggagtc ctggtcaccg tcccctcagc c
//
LOCUS       KCXD01006762             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:22673:9492
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006762
VERSION     KCXD01006762.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:22673:9492"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65244.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       261..273
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           79 a           78 c           87 g           76 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactatg
       61 gcatgcactg ggtccgccag gccccaggga aggggctgga ttgggtggca gttatgtcgt
      121 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggcct
      241 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006763             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15347:15964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006763
VERSION     KCXD01006763.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15347:15964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..432
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65245.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       435..459
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          105 a          128 c          158 g          126 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtctg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agctttggcg atcatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcta tcagtaatac
      301 tggtaaagcc gtacactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtgta
      421 ttactgttct agcgattact atagtggtag ttattactat tggggctacg gcttggattc
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006764             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21486:10795
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006764
VERSION     KCXD01006764.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21486:10795"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65246.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       438..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          119 c          150 g          122 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtttc
      121 tattctaaga ggtgtccact gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctggggag tccctgagac tctcctgtgg agcctctgga ttcaccttca ttacttctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtgtctg taatttcgtc
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caactccaag aacacactat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006765             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20577:18714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006765
VERSION     KCXD01006765.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20577:18714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65247.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          150 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatctcga
      301 acgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006766             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16672:17783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006766
VERSION     KCXD01006766.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16672:17783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65248.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          141 c          134 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctgttgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatgggg agtgttgatc ctcaatatgg tgagatgata
      301 gacgcagaga aattccaggg cagagtctcc atgaccgagg acacgtctac agacacagcc
      361 tacatagagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006767             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:3275:14770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006767
VERSION     KCXD01006767.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:3275:14770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65249.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       408..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          130 c          136 g          107 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctccggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctctatca gcagtagtta ctgcagctgg atccgccaga ccccagggaa gggactggag
      241 tggattgggt atatttatgg gagtgatagt agtaccaaat acaacccctc cttcaagagt
      301 cgagtcaccc tgtcagtaga cacgtccaag aaccggtgtt ccctgaagct gaactctgtg
      361 accgccgcgg acacggccgt gtattattgt gcgagttcgg gtatagaagt ggttgcctac
      421 agcattgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006768             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20304:14010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006768
VERSION     KCXD01006768.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20304:14010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65250.1"
                     /translation="CATGRIGSSCWSNLFTGLESW"
     D_segment       427..435
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          146 c          143 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaattca
      301 cgcagagaaa ttccagggca gagtcacctt gaccgaggac acgtccacag acacagccta
      361 catggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagc agctgctggt ccaacctctt caccggtttg gaatcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006769             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13628:3871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006769
VERSION     KCXD01006769.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13628:3871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65251.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          116 c          151 g          123 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcttccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 aatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catttctaga
      361 gacaattcca tgaacatgct atttcttcaa atgaacaacc tgaacttgga cgacacggcc
      421 gtctattact gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006770             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17754:20565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006770
VERSION     KCXD01006770.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17754:20565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..276
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..276
     V_segment       8..187
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <181..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65252.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       196..218
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       236..276
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        277..>282
                     /gene="IGHG"
BASE COUNT           65 a           68 c           86 g           63 t
ORIGIN      
        1 acatggggac aggcccctgg acaagggctt gggtggatgg gagggatcat ccctcttgtt
       61 ggtgtgacaa actacgaaca gaagttccag ggcagagtca cgattaccgc ggacacgtcc
      121 acgaatacag tcttcatgga actgagcagc ctgagatctg aggacacggc cgtctactat
      181 tgtgcgacag gggtatatta ccaggatgaa tacggttatt tttatgtcgg cggtgacttt
      241 gactactggg gccagggagt cctggtcacc gtctccccag cc
//
LOCUS       KCXD01006771             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17274:17413
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006771
VERSION     KCXD01006771.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17274:17413"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65253.1"
                     /translation="CARDAYGRGFDYW"
     D_segment       447..451
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          118 c          153 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggacgtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gccttggttc
      181 agcccggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcattcactg ggtccgccag tctccaggga aggggctgga gtgggtggca gtgatttcgt
      301 acgatgaaac taagaaatac cacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggcct
      421 tgtattactg tgcgagagat gcgtacggga gggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006772             317 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:14694:3436
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006772
VERSION     KCXD01006772.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 317)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 317)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:14694:3436"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..315
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..315
     V_segment       8..238
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <234..>284
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65254.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       246..263
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       265..315
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        316..>317
                     /gene="IGHG"
BASE COUNT           80 a           86 c           85 g           66 t
ORIGIN      
        1 acatgggggt ctcctgcaag gtttccggat acaccttcac cgaattatcc atgcactggg
       61 tgcgacaggc ccctgggaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg
      121 aaatgaaaca cacagagttc catgccagat tcaccatgac cgaggacacg tctacagaca
      181 cggcctacat ggagctgagc agcctaagat cagaggacac ggccctgtat tactgtgcag
      241 tcggatatag cggcagatgg aacaactggt acttcgatct ctggggccct ggcaccccaa
      301 tcaccatctc ctcagcc
//
LOCUS       KCXD01006773             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14615:19595
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006773
VERSION     KCXD01006773.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14615:19595"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..455
     V_segment       104..395
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65255.1"
                     /translation="CATGGLRTPHYW"
     D_segment       402..409
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           84 a          144 c          133 g           96 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tggctccatc agcggttact ggtggtcctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tatatcggtg gtactagtgg gagcacctac tacaacccct ccctcaagag
      301 tcgagtcacc ttttcaacag acacgtccaa gaaccagttc tccctgaccc tgacctctgt
      361 gagcgccgcg gacacggccg tatattactg tgcgaccgga ggactacgga ccccccacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006774             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:27291:11282
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006774
VERSION     KCXD01006774.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:27291:11282"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65256.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       282..288
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           81 a           80 c           96 g           75 t
ORIGIN      
        1 acatgggggt tcagccgggg gggtccctga gactctcctg tgcagcctct ggattcacct
       61 tcagtaacta tggcatacac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
      121 cagttatatc gtctgatgga agtaagacat actacgcaaa ctctgtgaag gaccgattca
      181 ccatattaag agacaattcc aagagcatgc tctatcttca aatgaacaac ctgaaattgg
      241 aggacacggc cgtctattac tgtgcgagag acgatatggg aagtggcttt gactactggg
      301 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006775             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24414:16230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006775
VERSION     KCXD01006775.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24414:16230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65257.1"
                     /translation="CARYPEIQLHLAYFDYW"
     D_segment       412..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           99 a          139 c          127 g          109 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctctccc tcacatgcgc tgtctctggt
      181 ggctctatca gcagtattca ctggtggagc tggatccgcc agcccccagg gaaagggctg
      241 gagtggattg ggtatattag tggtgatagt cgtaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aagaaccagt tctccctgaa gctgagctct
      361 ctgaccgccg cggactcggc cgtgtattat tgtgcgagat atccagaaat acaactacac
      421 ttagcctact ttgactactg gggtcaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006776             338 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:9018:20599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006776
VERSION     KCXD01006776.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 338)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 338)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:9018:20599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..336
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..336
     V_segment       8..269
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>305
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65258.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       276..283
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..336
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        337..>338
                     /gene="IGHG"
BASE COUNT           73 a           82 c          104 g           79 t
ORIGIN      
        1 acatgggggt aaagcctggg gggtccctga gactctcctg cgcggcctct ggattcagct
       61 tcagttattt ctacatgagc tgggtccgtc aggctccagg gaaggggctg gagtggatct
      121 caagtattga cagtggtggg actaccgcta attatgcaga ctccgtgagg ggcagattca
      181 tcatctccag agagaacgcc aagaatacag tgtatcttca aatggacagc ctgagagctg
      241 aggacacggc tgtctattat tgtgcgagag cgcgcggggt gatcattaca tactttgact
      301 cctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006777             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:12249:21658
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006777
VERSION     KCXD01006777.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:12249:21658"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65259.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           95 a          138 c          127 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactagagtg
      241 gattgggtat atctctggtg cttatgggag caccacctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006778             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11032:4474
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006778
VERSION     KCXD01006778.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11032:4474"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65260.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       444..453
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          112 a          118 c          148 g          118 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcaact ggtggagtct ggaggaggct tggttcggcc
      181 tggggggtcc ctgagactct cctgttcagc ctctggattc accttcagta attttggcat
      241 ccactgggtc cgccaggctc cagggaaggg cctggagtgg gtggcagtta catcgtctga
      301 tgaaagtaag aaatactatg cagactctgt gaaggaccga ttcaccctct ccagagacaa
      361 ttccaagaat atactatatc ttcaaatgaa caacctgaag ttggaggaca cggccgtcta
      421 ttactgtgcg agagacgcat atggcagcgg ctgtgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006779             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21185:19535
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006779
VERSION     KCXD01006779.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21185:19535"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65261.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       439..451
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          117 c          150 g          119 t
ORIGIN      
        1 atggggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtaca gtctctggat tcaccttcag tagctttggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatgtcgtct
      301 gatggaagtt acaactacta cgcagactct atgaaggacc gattcaccat ctccagagac
      361 aattccaaga acaccctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattactgtg cgagagggga atacagtaac tctattgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006780             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:20777:9599
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006780
VERSION     KCXD01006780.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:20777:9599"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..415
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65262.1"
                     /translation="CAIGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           96 a          145 c          146 g          111 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct aactactatt ggatcagttg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgataggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006781             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14411:15449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006781
VERSION     KCXD01006781.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14411:15449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65263.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       422..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          142 c          143 g          103 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tccaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgctcc tctatatggt gaaatgatgc
      301 tcgcagacaa cttccagggc agagtcacct tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgacg acacggccgt gtattactgt gcgcgtgggc
      421 ctattacaat ttttggcgta cttattacgg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006782             387 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:24169:10785
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006782
VERSION     KCXD01006782.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 387)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 387)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:24169:10785"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    163..385
                     /note="immunoglobulin heavy chain variable region"
     V_region        163..385
     V_segment       163..324
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <316..>354
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65264.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       333..337
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       339..385
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        386..>387
                     /gene="IGHG"
BASE COUNT           89 a           79 c          118 g          101 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagtg ggtggcagtt
      181 atatcgtatg atggaagtaa gaaatattac gcagactctg tgaaggaccg attcaccatt
      241 tccagtgaca gttccaagaa catggcatat cttcaaatga acaacctgaa attggaggac
      301 acggccgtgt attattgtgt gagagatgcg tttggttccg gtttggattc ctggggcctg
      361 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006783             321 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8898:3874
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006783
VERSION     KCXD01006783.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 321)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 321)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8898:3874"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..319
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..319
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>288
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65265.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       267..278
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..319
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        320..>321
                     /gene="IGHG"
BASE COUNT           82 a           75 c           92 g           72 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgc gcagcttccg gattcacctt cagtttctat
       61 ggcatgcact gggtccgcct ggctccaggg aaggggctgg agtgggtggc agttacatcg
      121 aatgatgaaa gtaagaaata ctacggagac tctgtgaagg accgattcac catctccaga
      181 gacaattcca agaacatagt atatcttcaa atgaacaacc tgaaattgaa ggacacggcc
      241 gtgtactact gtgggagaga tgataatggg gtgattatcg actactgggg ccagggagtc
      301 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006784             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6369:14784
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006784
VERSION     KCXD01006784.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6369:14784"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65266.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       400..409
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           83 a          136 c          138 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtgttt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtca ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggta gtggtgggaa cacctactac aagtcgtccc tccagagtcg
      301 agtcaccatt tcaaccgaca cgtccaagaa ccagttctcc ctgacactga cctctgtgac
      361 cgccgcggac acggccctct attactgtgc gagggggaat atagcagcga ctggcattga
      421 ttactggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006785             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:17096:11629
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006785
VERSION     KCXD01006785.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:17096:11629"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65267.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       412..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          106 a          140 c          139 g           96 t
ORIGIN      
        1 acatggggag catccaacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatggt
      301 gttccagggc agagtcacca tgaccgagga cacgtctata gacacagcct acatggagtt
      361 gagcagcctg agatctgagg acacggccgt gtattactgc gcgattggcc ctagcggcaa
      421 ctggaacggc tggtccttcg atatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01006786             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15367:16420
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006786
VERSION     KCXD01006786.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15367:16420"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65268.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          113 a          142 c          150 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgagatccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgccag gtgtccggat ccacgttcag tgaaatctcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga gatctgacga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006787             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8854:18391
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006787
VERSION     KCXD01006787.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8854:18391"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..490
     V_segment       118..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65269.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       417..431
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          108 a          141 c          141 g          102 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatccac cttcaccgaa ttatccatac actgggtgcg gcaggcccct
      241 ggaaaagggc ttgagtggat gggaggtgtt gctcctctat atggtgaaat gatgctcgca
      301 gacaacttcc agggcagagt caccttgacc gaggacacgt ctacagacac agcctacatg
      361 gagctgagca gcctgagatc tgacgacacg gccgtgtatt actgtgcgcg tgggcctatt
      421 acaatttttg gcgtacttat tacggggctt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006788             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10316:10749
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006788
VERSION     KCXD01006788.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10316:10749"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65270.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       410..416
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          118 a          141 c          126 g           99 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaagt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggaacca ccttcaccga attatccctg cactgggttc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagttt taatcctata tatggtgaaa ttttacacac
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgacat ctgaggacac ggccgtgtat tactgtgcgg cagctgatag
      421 tggttaccca ttttactact tcgatatctg gggccctggc accccaatca ccatctcctc
      481 agcc
//
LOCUS       KCXD01006789             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8703:15065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006789
VERSION     KCXD01006789.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8703:15065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..502
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65271.1"
                     /translation="CARRPFGSDAFDFW"
     D_segment       448..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          112 a          116 c          156 g          120 t
ORIGIN      
        1 acatggggga ggtctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtcactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 catgatgaaa ataagaaata ctacgcagac tctgtgaagg accgcttcac catctccaga
      361 gacaattcca agaacatgct gtatcttcaa atgaacagcc tgaagttgga ggacacggcc
      421 atgtattact gtgcgagacg accgttcggt agtgatgctt ttgatttctg gggccaaggg
      481 ctcagggtca ccgtctcttc agcc
//
LOCUS       KCXD01006790             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18394:9540
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006790
VERSION     KCXD01006790.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18394:9540"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65272.1"
                     /translation="CAKTDYSGSLVYW"
     D_segment       421..430
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          101 a          142 c          130 g          106 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttcattt ctgtcctcca
       61 ccacgatggg gtcaactgcc atcctcgccc tcctcctggc tgttctccaa ggagtctgtg
      121 ccgaggtgca gctggtgcag tctggaccag aattgaaaag gcccggggag tctctgagga
      181 tatcctgtga gacttctgga tacagcttta ccagcaggtg gatcagctgg gtgcgccaga
      241 tgcccgggaa agacctggag tggatgggga ccatctatcc tggtgattct gagaccaaat
      301 acaacccgtc cttccaaggc cacgtcacta tctctgccga caagtccatc agcaccacct
      361 atctacagtg gagcagtctc aaggcctcgg acaccgccac gtacttctgt gcgaaaaccg
      421 actatagtgg aagtttggtc tactggggac agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006791             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:5888:7136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006791
VERSION     KCXD01006791.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:5888:7136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65273.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          142 c          134 g           96 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatccact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagtagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01006792             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:10509:20117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006792
VERSION     KCXD01006792.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:10509:20117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65274.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       413..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           96 a          139 c          127 g          108 t
ORIGIN      
        1 acatggggaa acgctctctg agaggcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctgctg gcagctccca gatgggtcct gtcccaggtg cagttgcagg
      121 agtcgggccc acgactggtg aagccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtgactccat cagcagtacc ttctggagct ggatccgcca gcccccaggg aaggggctgg
      241 agtggattgg ctatatctat ggtgctactg ggagcaccgg ctacaacccc tccctcaaga
      301 gtcgagtcag catttcaaca gacacgtcca agaaccagtt ttccctgaaa ctgaactctg
      361 tgaccgccgc ggacaccgcc gtatattact gtgcgagata tagcgatact gatagttatt
      421 acttctttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006793             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13704:4709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006793
VERSION     KCXD01006793.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13704:4709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65275.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       416..422
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          138 c          139 g           99 t
ORIGIN      
        1 acatgggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccacc tggtacagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcaaag tttccggata caccttcacc gatttatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggaggt gttgatactg tatctgatgg aatgatatac
      301 gcagaaaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgc gagaggtgtg
      421 acagcagacg tcttcggttt cctcgggctt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01006794             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:5201:12191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006794
VERSION     KCXD01006794.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:5201:12191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65276.1"
                     /translation="CARDQDSYVYYRFFDFW"
     D_segment       406..418
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          144 c          124 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acgtgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgt
      181 ctccatcaac gattaccatt ggagctggat ccgccagccc cctgggaagg gactggagtg
      241 gattggacat atctctcata gtcgtggaag caccgactac aacccctccc tcaagagtcg
      301 cgtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga gctctatgac
      361 ccccgcggac acggccgtct attactgtgc gagagatcag gattcttacg tttactatcg
      421 cttctttgac ttctggggcc agggagtcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01006795             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:7936:5938
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006795
VERSION     KCXD01006795.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:7936:5938"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..487
     V_segment       140..427
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65277.1"
                     /translation="CTGGAYANLDYW"
     D_segment       440..444
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..487
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>493
                     /gene="IGHG"
BASE COUNT          108 a          130 c          151 g          104 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cactgaacac agaggactca ccatggagtc tgggctgagc tgggttttcc ttgttgcttt
      121 tttaagaggt gtccagtgtg aggtgcagat ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagtc gctactggat
      241 gaactgggtc cgccaggctc caggaaaggg gctagaatgg gtctcagcta ttaatactga
      301 tggggagaac acatactacg cagactccgt gaagggccga ttctccatct ccagagacaa
      361 ctcaaagacc acactctccc tgcaaatgaa cagcctgaga ccggaggaca cggccgtata
      421 ttactgtacg ggcggggcgt acgctaacct cgactactgg ggccagggag tcctggtcac
      481 cgtctccaca gcc
//
LOCUS       KCXD01006796             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13448:9046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006796
VERSION     KCXD01006796.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13448:9046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65278.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          138 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc ggctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg cgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006797             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6400:5800
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006797
VERSION     KCXD01006797.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6400:5800"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65279.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       427..439
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          138 c          150 g           99 t
ORIGIN      
        1 acaggggatc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtaaaggtc
      181 tcctgccagg tttccggata caccttcagt gagatgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gttgctcctg gaaatggtga aataatacac
      301 gcagagaact tccaggacag agtcaccatg accgaggaca cgtctataga catagcctac
      361 atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gacagggagg
      421 ttcgggagca gcgtctggtc cagcctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006798             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23747:17924
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006798
VERSION     KCXD01006798.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23747:17924"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65280.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       442..449
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..500
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          114 c          150 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagacc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccaat gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcacgttca gtaactatgg
      241 gatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 cgatgaaaat aagaaatact acgcagactc tctgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgcttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gcgaggaggc cctggaatgc agatgctttt gatttctggg gccaaggact
      481 cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01006799             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22511:11687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006799
VERSION     KCXD01006799.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22511:11687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65281.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          113 a          144 c          134 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatacacct tcaccgaatt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc tacatggaac
      361 tgaatagcct gacatctgag gacacggccg tatattactg tgcgactggc cctagcggca
      421 cctggaacgc ctggtacctc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01006800             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18328:19234
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006800
VERSION     KCXD01006800.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18328:19234"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65282.1"
                     /translation="CAKGETATPYYGLDSW"
     D_segment       435..443
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          126 c          152 g          110 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagatg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatac
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ctcagctatt agaactggtg
      301 gtaggacatt ctacgcagac tccgtgaagg gccgattcac catctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc atgtattact
      421 gtgcgaaagg ggaaacagct acaccttact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006801             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25534:3494
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006801
VERSION     KCXD01006801.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25534:3494"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65283.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       399..403
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           96 a          145 c          134 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggttcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc acttcctact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattggatat atctatgctg atagtgggac caccagctac aacccgtccc tcaagagtcg
      301 agtcaccatt tcaatagaca cgtccaagaa tctgtactcc ctgaaactga gctctgtgac
      361 cgccgcggac acggcctttt attactgtgc gagacgtcct actcgcacgc gggttctata
      421 tgaggcgaca ggggaagact ttgactcctg gggccaggga ctcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01006802             322 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14830:13360
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006802
VERSION     KCXD01006802.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 322)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 322)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14830:13360"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..320
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..320
     V_segment       8..245
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <239..>289
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65284.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       263..271
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       272..320
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        321..>322
                     /gene="IGHG"
BASE COUNT           75 a           88 c           95 g           64 t
ORIGIN      
        1 acatgggggg gcctcagtga aggtctcctg caaggtttcc ggaaacacct tcaccgaatt
       61 gtccatgcac tgggtgcgac aggcccctgg aaaagggctt gagtgggtgg gaagtgttga
      121 tcctgcatat ggtgaaatga cgttccaggg cagagtcacc atgaccgagg acacgtctac
      181 agacacagcc tacatggaac tgagcagcct gacatctgag gacacggccg tgtattactg
      241 cgcgattggc cctagtggca gatggaacga ctggtccttc gacatctggg gacctggcac
      301 cccaatcacc atctcctcag cc
//
LOCUS       KCXD01006803             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14850:19799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006803
VERSION     KCXD01006803.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14850:19799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..492
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65285.1"
                     /translation="CARGRSGGVWPNSFDYW"
     D_segment       430..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          132 c          147 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcatagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggccccagg aaaagggctt gagtggatgg gaagtgttga tcctgtatat gatgaaataa
      301 ttgtcgcaga gaatttccag gacagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctggaatctg aggacacggc cgtgtattac tgtgcgagag
      421 ggaggagtgg tggtgtctgg ccgaactcct ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006804             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14200:4303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006804
VERSION     KCXD01006804.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14200:4303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65286.1"
                     /translation="CAKGGWWGDYPPSDWFDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           97 a          148 c          143 g          110 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc tgctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctta acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctggtgattc taataccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggaccagcct gaaggcctcg gacaccgcca cctattattg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggttcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006805             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11951:5254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006805
VERSION     KCXD01006805.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11951:5254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..260
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65287.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       273..279
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       280..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           80 a           76 c           93 g           74 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtaact
       61 atggcataca ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttatat
      121 cgtctgatgg aagtaagaca tactacgcaa actctgtgaa ggaccgattc accatattaa
      181 gagacaattc caagagcatg ctctatcttc aaatgaacaa cctgaaattg gaggacacgg
      241 ccgtctatta ttgtgcgaga gacgatatgg gaagtggctt tgactactgg ggccagggag
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006806             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6600:6415
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006806
VERSION     KCXD01006806.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6600:6415"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..459
     V_segment       84..383
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65288.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       388..404
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..459
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           99 a          140 c          118 g          104 t
ORIGIN      
        1 acatgggggg actcctgtgc cccaccatgg acacgctttg ctacacactc ctgctactga
       61 ccgtcccgtc ctgggtcttg tcccaggtga ccttgaagga gtctggtcct gcgctggtga
      121 aacccacaca gaccctcacg ctgacctgca ccttctctgg gttctcaatc agtacttctg
      181 caacaggtgt gggctggatc cgtcagcccc cagggaaggc cctggaatgg cttgcaagca
      241 tttattggaa tgatactaaa ttcttcagca cttcgctgaa gagcagactc accgtctcca
      301 aggacacctc caaaacccag gtggttctaa caatagccaa catggaccct gtggacacag
      361 ccacatatta ctgtgcacgg atacagggtg gtagttacta ctacggtggg ggatacttcg
      421 agttctgggg ccagggcgcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006807             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12195:4249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006807
VERSION     KCXD01006807.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12195:4249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65289.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          117 a          114 c          146 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtac aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaattttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgccaact ctgtgaagag ccgattcacc atttccagag
      361 acaattccaa gagcatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01006808             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:20256:16163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006808
VERSION     KCXD01006808.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:20256:16163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..464
     V_segment       83..380
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <371..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65290.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       386..403
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          104 a          139 c          117 g          106 t
ORIGIN      
        1 acatggggga atcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggccttgt cccaggtcac cttgaaggag tctggtcctg cgctcgtgaa
      121 acccacacag accctcacgc tgacctgcac cttctctggg ttctcaatca cctctactgg
      181 aagaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccat
      241 ttattggaat gatagtaaat actacagtac atcgctgaag agcaggctca ccgtctccaa
      301 ggacacctcc aaaaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc
      361 caaatattac tgtgcacggg attactgtag tggtatttac tgcgatgtga atgggcacta
      421 ctttgacctc tggggccagg gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01006809             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14223:6987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006809
VERSION     KCXD01006809.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14223:6987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65291.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       421..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          109 a          141 c          147 g          107 t
ORIGIN      
        1 acatggggga cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tctcaggtcc agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag
      181 ctctcctgta aggcttctgg atacagcttc agcatctatg tcatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc
      361 tacatggacc tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt
      421 tactgtactg gcaatggttg taaccttact ttcaaccggc tcgatgtctg gggcccggga
      481 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01006810             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:19361:15377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006810
VERSION     KCXD01006810.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:19361:15377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65292.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           90 a          138 c          133 g           98 t
ORIGIN      
        1 acatggggaa gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca acagtggtta tggctggagc tgggtccgcc agcccccagg gaagggtccg
      241 gagtggattg ggtgtctcta tgatagtagt ggcaacacgt accacaaccc ctccctcaag
      301 agtcgcgtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa cctgaggtct
      361 atgaccgccg cggacacggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006811             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:13688:18488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006811
VERSION     KCXD01006811.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:13688:18488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    95..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        95..455
     V_segment       95..388
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65293.1"
                     /translation="CARDSDSREFSFDYW"
     D_segment       403..407
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT          107 a          108 c          129 g          113 t
ORIGIN      
        1 acatggggtg atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt
       61 tttccttgtt gctattttaa gaggtgtcca gtgtgaggtt cacctgctgg agtctggagg
      121 aggcttggtt cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt
      181 cagtagctat ggcatacact gggtccgcca ggctccaggg aaggggctgg actgggtggc
      241 agttatatcg tatgatggaa gtaagaaata ctacgcagac tctgtgaatg accgattcac
      301 catctccaga gacaattcca acaacatgct atatcttcaa atgaacaacc tgaaattgga
      361 ggacacggcc gtgtattact gtgcgagaga ttccgactcc cgagaattca gttttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006812             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14441:4830
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006812
VERSION     KCXD01006812.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14441:4830"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    86..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        86..467
     V_segment       86..382
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <374..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65294.1"
                     /translation="CARLFCSGIYCDAVTHSFDYW"
     D_segment       388..396
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT          101 a          145 c          116 g          107 t
ORIGIN      
        1 acatgggggg tgaatcctgt gccccaccat ggacacgctt tgctacacac tcctgctact
       61 gaccgtcccg tcctgggtct tgtcccaggt caccttgaag gagtctggtc ctgcgctcgt
      121 gacacccaca cagaccctca cgctgacctg caccttctct gggttctcaa tcagaacttc
      181 tggaacaggt gtgggctgga tccgtcagcc cccagggaag gccctggaat ggcttgcaac
      241 catttattgg aatgatagta aattctacag cacatcgctg aagagcagac tcaccatctc
      301 cgaggacacc tccaaaaagc aggtggttct gacactgacc aacatggacc ctgtggacac
      361 agccacatac tactgtgcac ggctcttttg tagtggaatc tactgcgatg ctgtgacgca
      421 ctcctttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006813             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14005:15799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006813
VERSION     KCXD01006813.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14005:15799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    178..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        178..448
     V_segment       178..387
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65295.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       394..406
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..448
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT          107 a           94 c          141 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agttagggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agtagtaatg gcatgcactg ggtccgccag gttccaggga aggggctgga gtgggtggca
      241 gttatatcgt atgatgtaag taagaaatac tacgcagact ctgtgaagga ccgattcacc
      301 atctccagag acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag
      361 gacacggccg tgttctactg tgtgagagac tcttatggga gtggtttgga tgcctggggc
      421 caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006814             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9644:15845
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006814
VERSION     KCXD01006814.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9644:15845"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65296.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       445..449
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          122 c          148 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttcctttgg
      241 catgcactgg gtccgccagg caccggggaa ggggctggag tgggtggcag ttttatcgtc
      301 tgatggaagt aacaaatact acgcagactc tttgaaagac cgattcacca tatccagaga
      361 caactccaag aacatactat atcttcaact gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctc ggggcttgac tactggggcc agggagtcct
      481 gctcaccgtc tcctcagcc
//
LOCUS       KCXD01006815             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21311:14564
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006815
VERSION     KCXD01006815.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21311:14564"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65297.1"
                     /translation="CARMWYWPTPDVW"
     D_segment       405..411
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..460
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           85 a          132 c          141 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgag gccttcggag accctgtccc tcacctgcgt tgtctctggt
      181 ggctccatca gcggtggtta tggctggaac tggatccgcc aggccccagg gaagggactg
      241 gagtggattg ggagtctctt tggcagtagt ggaagaacct actacaatcc gtccctcaag
      301 agtcgagtcg ctatttcaaa agacacgtcc aagaaccagt tctccctgat cctgaggtct
      361 gtgaccgccg cggacacggc cgtgtattac tgtgcgagaa tgtggtactg gccgaccccc
      421 gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006816             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18946:2559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006816
VERSION     KCXD01006816.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18946:2559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65298.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          113 a          145 c          130 g           91 t
ORIGIN      
        1 acatggggca tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctgcactgg gtgcgacagg
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggt aaagtggact
      301 acacacagaa gttccgagac agactcacca tcaccgcgga catgtcgaca gagacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac tactggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006817             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13030:14285
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006817
VERSION     KCXD01006817.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13030:14285"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65299.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          110 c          156 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccatttggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtc
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagaaacttt
      241 ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc tgttatatcg
      301 tatgatgaaa ataacaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaatatggt atatcttcaa atgaagaacc tgaaattggg ggacacggcc
      421 gtgtattatt gtgtgagaga tgtcagggga acggggtttg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006818             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:14903:14146
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006818
VERSION     KCXD01006818.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:14903:14146"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..494
     V_segment       115..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65300.1"
                     /translation="CAKSVNYEEDNGYYLPTGFDYW"
     D_segment       416..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>498
                     /gene="IGHG"
BASE COUNT          113 a          139 c          146 g          100 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aaccctggtg cctcagtgaa gctctcctgc
      181 aagggttctg gattcaccct cagcaccgag gccatcagtt gggtgcgaca ggcccctgga
      241 caaggacctg actggatggg agggatcatc cctctcgtgg gtgcaacaaa ctacgcacag
      301 aagttccagg gcagagtcaa gtttaccgcg gacacgtcca taaacacagc ctacatggaa
      361 ctgagcggcc tgagatctga ggacacggcc gtgtattatt gtgcgaaatc cgtgaattac
      421 gaggaagata acggttacta tttaccgacg gggtttgact actggggcca gggagtcctg
      481 gtcaccgtct cctctgcc
//
LOCUS       KCXD01006819             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12404:11150
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006819
VERSION     KCXD01006819.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12404:11150"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..433
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65301.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          114 a          120 c          145 g          133 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agctggtgga atctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctca attcaccttc agttcctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctgga gtgggtttcc ggtattaaca
      301 ttggcggtga cacatactac ccagactctg tgaagggtcg attcactatc tccagagaca
      361 atgccaagaa ctccttgtat cttcaaatga acagcctgag agttgaggac actgctgtgt
      421 atttttgtac aagggggata gataactacc actttagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006820             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10647:11541
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006820
VERSION     KCXD01006820.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10647:11541"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..497
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65302.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>501
                     /gene="IGHG"
BASE COUNT          113 a          117 c          149 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt caatcactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg attgggtggc agttatgtcg
      301 tttgatgaaa atgtgaaatt ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 ctgtattact gtgcgagagg ggaatacagt aactctattg acttctgggg ccagggagtc
      481 ctggtcaccg tctcctccgc c
//
LOCUS       KCXD01006821             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:3630:14617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006821
VERSION     KCXD01006821.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:3630:14617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65303.1"
                     /translation="CTGGAYANLDYW"
     D_segment       438..442
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          105 a          128 c          155 g          103 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgcttttt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcgc tactggatga
      241 actgggtccg ccaggctcca ggaaagggac tggagtgggt ctcagctatt aatagtgatg
      301 gggagaacac atactacgca gactccgtga agggccgatt ctccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gcctgagacc ggaggacacg gccgtgtatt
      421 actgcacggg cggggcatac gctaacctcg actactgggg ccagggagtc ctggtcaccg
      481 tctcgtcagc c
//
LOCUS       KCXD01006822             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16171:9232
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006822
VERSION     KCXD01006822.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16171:9232"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65304.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       447..452
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          155 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag gggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtaaaatcgt
      301 ttgatggaac taagatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcctacggga gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006823             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12115:21631
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006823
VERSION     KCXD01006823.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12115:21631"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..420
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65305.1"
                     /translation="CAREYCTSSTCAGFLDSW"
     D_segment       421..432
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          142 c          136 g          106 t
ORIGIN      
        1 acatggggag catcacaaaa caaccacatc cctcctctaa agaagcccct gggagcacag
       61 ctcatcacca tggactggac ctggaggctc ctctttgtgg tggcagcagc tgcaggtgtc
      121 cagtcccagg tccgcctggt gcagtccggg actgaggtga agaagcctgg ggcctcagtg
      181 aagatttcct gcggggcttc tggtttcacc ctcgacacct atggtatcaa ctgggtgcga
      241 caggcccctg gacaagggct tgagtggatg ggagtgatca tcccccttat tggtatcatc
      301 aactacgcag agaactctca gggcagactc acaataaccg cgaacacgtc cacaaataca
      361 gcctatatgg aactgagcag tctgagatct gaggacacgg ccatctatta ctgtgcgaga
      421 gaatactgta cttctagtac ttgcgccggg ttccttgact cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006824             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18328:10350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006824
VERSION     KCXD01006824.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18328:10350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65306.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          127 c          157 g          121 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactactt
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaccag
      301 tggtggggat aacacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag accacactgt atcttcacat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcaagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006825             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14887:17383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006825
VERSION     KCXD01006825.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14887:17383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..515
     V_segment       134..427
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65307.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          109 a          117 c          155 g          136 t
ORIGIN      
        1 acatggggga gccacagccc cgggattccc agctgtctcc acttggtcat gaacactgaa
       61 ctcagaagac gcaccatgga gtttgtgctg agtttgcttt tccttgttgc tttttttaaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtaa agcctggggg
      181 gtccctgaga ctctcttgtg tagtctctgg attctccttc agtaactatg ttatgcattg
      241 ggtccgccag gctccaggaa agggtctgga gtgggtctca cttattagtg gaagtggtgg
      301 taccacagac tacgcagact ctgtgaaggg ccgattcacc ctctccagag acaacgccaa
      361 ggaatcgctt tttctgcaaa tgaacagcct aagagccgag gacacggccg tgtattactg
      421 tgctagaggc ggggaaatag tggattcaga gattattgag gattactacg gtttggattt
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006826             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13793:19868
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006826
VERSION     KCXD01006826.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13793:19868"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..269
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65308.1"
                     /translation="CARADRGSSIDYW"
     D_segment       277..283
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>332
                     /gene="IGHG"
BASE COUNT           78 a           83 c           93 g           78 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgtagcctct ggattcacct
       61 tcagaaccta tggcttacac tgggtccgcc aggccccagg gaaggggctg gagtgggtgg
      121 cggttatatc atatgatgat gacaagaaat attacgcaga ctctgtgaag gaccgattca
      181 ccatctccag agacaattcc aagaacattc tttatcttca aatgaacaac ctgaaattgg
      241 aggacacggc cgtgttttat tgtgcgagag cggatcgcgg cagttcaatt gactactggg
      301 gccagggagt cctggtcacc gtctccccag cc
//
LOCUS       KCXD01006827             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13576:8502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006827
VERSION     KCXD01006827.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13576:8502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..495
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65309.1"
                     /translation="CARGPITIFGVLITGLDYW"
     D_segment       422..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          142 c          142 g          103 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctgggtctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tccaccttca ccgagttatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgctcc tctatatggt gaaatgatgc
      301 acgcagacaa cttccagggc agagtcacct tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgacg acacggccgt gtattactgt gcgcgtgggc
      421 ctattacaat ttttggcgta cttattacgg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01006828             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22237:12467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006828
VERSION     KCXD01006828.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22237:12467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65310.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          111 c          154 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtata tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtcagttata tcgtctgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 caaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006829             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15901:12813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006829
VERSION     KCXD01006829.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15901:12813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65311.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          115 c          147 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca actggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acgcaaactc tgtgaagagc cgattcacca tctccagaga
      361 caattccaag aacatacttt atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atattgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006830             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9522:16481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006830
VERSION     KCXD01006830.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9522:16481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65312.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           97 a          136 c          128 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcaaggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tactggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattggca gtatctctgg tgcttatggg agcaccagtt ataacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006831             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:16062:5277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006831
VERSION     KCXD01006831.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:16062:5277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65313.1"
                     /translation="CARVSGHTEGTVENFYYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          119 a          111 c          157 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc tgctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagtttc agtggctttg
      241 gcatacactg ggtccgccag gctcctggga aggggctgga gtgggtgtca cttatatcgt
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcatc atgtccagag
      361 acaattccaa gaacaaggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagagtt agtggtcata cagagggtac agttgaaaac ttttactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006832             418 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21989:23485
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006832
VERSION     KCXD01006832.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21989:23485"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    47..416
                     /note="immunoglobulin heavy chain variable region"
     V_region        47..416
     V_segment       47..343
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <335..>385
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65314.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       354..368
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       375..416
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        417..>418
                     /gene="IGHG"
BASE COUNT           86 a          101 c          126 g          105 t
ORIGIN      
        1 acatgggggg tttttccttg ttgctatttt aaaaggtgtc cagggtgagg tgcagctggt
       61 ggagtctggg ggcggcttgg caaagcctgg ggggtccctg agactctcct gtgcagcctc
      121 tggattcacc ttcagtgact actggatgta ctgggttcgc cagacacctg agcaggggct
      181 ggagtggatc tcagctattg atagtgctgc tactagtacc acatactatg cagactccgt
      241 gaagggcaga ttcaccatct ccagagagaa cgccaaaaac acactgtatc ttcagatgga
      301 cagcctgaga actgaggaca cggctgtcta ttactgtgcg agagttccgg gcctagtggt
      361 atttactggt tcgcttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006833             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:22146:7126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006833
VERSION     KCXD01006833.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:22146:7126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..481
     V_segment       133..424
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65315.1"
                     /translation="CARADRGSSIDYW"
     D_segment       432..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>487
                     /gene="IGHG"
BASE COUNT          110 a          113 c          145 g          119 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaagactc accatgaagt ttgggctgag ttgggttttc cttgttgcaa ttttaagagg
      121 tgtccagtgt ggggtgcagc tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgtag cctctggatt caccttcaga acctatggca tgcactgggt
      241 ccgccaggcc ccagggaagg ggctggagtg ggtggcggtt atatcttatg atgatgacaa
      301 gaaatattac gcagactctg tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 cattctttat cttcaaatga acaacctgaa attggaggac acggccgtgt tttattgtgc
      421 gagagcggat cgcggcagtt caattgacta ctggggtcag ggagtcctgg tcaccgtctc
      481 cccagcc
//
LOCUS       KCXD01006834             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17829:3402
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006834
VERSION     KCXD01006834.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17829:3402"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65316.1"
                     /translation="CVKSGSASLHWYLEIW"
     D_segment       435..442
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..504
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          107 a          135 c          155 g          109 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcgg
      181 aacccggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattagta
      301 gtggtggaac cacatcctac gcagactccg tgaagggccg attcaccgtc tccagagaca
      361 actcaaaaaa cacgctgtcc ctgcagatga acagcctgag agctgaggac acggccgtgt
      421 attactgtgt gaagagtggg agtgccagcc ttcactggta cctcgaaatc tggggccctg
      481 gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01006835             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23730:6889
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006835
VERSION     KCXD01006835.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23730:6889"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65317.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       409..415
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          106 a          148 c          131 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cccggggcct cagtgaaggt
      181 ctcctgcaag gtctccggaa acaccttcac cgaattgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatccc gcatatggtg aaatgacgtt
      301 ccagggcaga gtcatcatga ccgaggacac gtctacagac acagcctaca tggaactgac
      361 cagcctgaca tctgacgaca cggccgtcta ttactgtgcg gttggcccta gtggcacttg
      421 gaaccactgg tccttcgata tctggggccc tggcacccca gtcaccatct cctcagcc
//
LOCUS       KCXD01006836             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14092:6988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006836
VERSION     KCXD01006836.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14092:6988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..396
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65318.1"
                     /translation="CARGSRRQPENW"
     D_segment       405..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           88 a          136 c          138 g           94 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatta gcggttactg gtggggctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggct atatcggtgg tactagtgaa aacacctact acaatccctc cctcaagagt
      301 cgagtcacca tttcaagaga cacgtccaag aaccaggtct ccctgaacct gacctctgtg
      361 accgccgggg acacggccgt gtattactgt gccagaggga gtcggcggca gccggaaaac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006837             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14290:11953
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006837
VERSION     KCXD01006837.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14290:11953"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65319.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       420..426
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          138 c          143 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat actgtatctg atggagtgat
      301 atacgcagaa aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattatt gtgcgagagg
      421 tgtgacagca gacgtcttcg gtttcctcgg gcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006838             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6394:2899
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006838
VERSION     KCXD01006838.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6394:2899"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65320.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       437..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          116 c          158 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg taaagcctgg
      181 ggggtccctg agactctcct gcgcggcctc tggattcagc ttcagttatt tctacatgag
      241 ctgggtccgt caggctccag ggaaggggct ggagtggatc tcaagtattg acagtggtgg
      301 gactaccgct aattatgcag actccgtgag gggcagattc atcatctcca gagagaacgc
      361 caagaataca gtgtatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ttgtgcgaga gcgcgcgggg tgatcattac atactttgac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006839             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18621:11040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006839
VERSION     KCXD01006839.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18621:11040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65321.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          118 a          147 c          141 g           96 t
ORIGIN      
        1 acatggggtt cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattaccc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgtggatcct gtaaatggtg aactaataca
      301 cgcagacaac ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga cacggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag cc
//
LOCUS       KCXD01006840             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:20276:12163
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006840
VERSION     KCXD01006840.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:20276:12163"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..491
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65322.1"
                     /translation="CARADRGSSIDYW"
     D_segment       442..448
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          113 a          115 c          148 g          121 t
ORIGIN      
        1 acatggagtc tgggagagga gcccagccct ggaagtccac agtgttccat tccgtgatca
       61 gcacagaaca cagaagactc accatgaagt ttgggctgag ttgggttttc cttgttgcaa
      121 ttttaagagg tgtccagtgt ggggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgtag cctctggatt caccttcaga acctatggca
      241 tgcactgggt ccgccaggcc ccagggaagg ggctggagtg ggtggcggtt atatcttatg
      301 atgatgacaa gaaatattac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa cattctttat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 tttattgtgc gagagcggat cgcggcagtt caattgacta ctggggtcag ggagtcctgg
      481 tcaccgtctc cccagcc
//
LOCUS       KCXD01006841             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14331:17994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006841
VERSION     KCXD01006841.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14331:17994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..488
     V_segment       131..423
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <416..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65323.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       429..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          113 a          113 c          146 g          118 t
ORIGIN      
        1 acatggggga gcccagccct ggaagaccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt
      241 ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtacg atgaaaataa
      301 gaaatactac gcagactctc tgaaggaccg attcaccatc tccagagaca attccaagaa
      361 catgctttat cttgaaatga acaacctgaa attggaggac acggccgttt attactgtgc
      421 gaggaggccc tggagtgcag atgcttttga tttctggggc caaggactca gggtcaccgt
      481 ctcttcagcc
//
LOCUS       KCXD01006842             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21803:7848
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006842
VERSION     KCXD01006842.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21803:7848"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..485
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65324.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       402..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          100 a          135 c          139 g          113 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga catcctgtgc gagaacatga agtatctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agttgcagga
      121 gtcgggccca ggactgatga agccttcaga gaccctgtcc ctcagctgcg ctgtctctgg
      181 tggctccata agtggtaact ggtggagctg gatccgccag cccccaggga agggactgga
      241 ctggattgga cgtatctctg gtactagtgg ggacaccaat tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttc tccctgaagc tgaactctgt
      361 gaccgccgcg gacgcggccg tgtattattg tgcaagagcg gattacgagg atgattacgg
      421 ttatcattta ggatacaact ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01006843             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:9249:10003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006843
VERSION     KCXD01006843.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:9249:10003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..494
     V_segment       143..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65325.1"
                     /translation="CANALTGGLDYW"
     D_segment       441..449
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          104 a          123 c          158 g          111 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 caccactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaggtactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctggag tgggtctcag ctattgcaag
      301 tggtggagaa agcacatact atgcagactc cgtgaagggc cgattcaccg tctccagaga
      361 caactcaaag aacacagtct ccctgcaaat gaacagtctt agcgcggagg acacggccgt
      421 gtattactgt gcgaatgcgt taactggggg tcttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006844             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17446:16914
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006844
VERSION     KCXD01006844.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17446:16914"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..475
     V_segment       109..400
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65326.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       406..425
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           94 a          140 c          132 g          111 t
ORIGIN      
        1 acatggggat gctgtctgag agtcagggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc aggtcccaga tgggtcctgt cccagccgca gctgcagctg
      121 caggagtcgg gcccaggact ggtgaagcct tcggagaccc tgtccctcga ctgcgttgtc
      181 tctggtggct ccatcagcga ttactcctgg agctggatcc gccagccccc agggaaggga
      241 ctggagtgga ttgggaatat tgatgttcat cttgcgggcc ccaactacaa cccctccctc
      301 aagagtcgag tcgccatttc aaaagacacg tccaagaatc agttctccct gaagctgagc
      361 tctgtgaccg ccgcggacac ggccgtatat ttctgtgcga aacaatatag tggtagttat
      421 tactattccc actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006845             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11602:15368
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006845
VERSION     KCXD01006845.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11602:15368"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65327.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          125 c          158 g          116 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 cattaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgacag
      301 tggtggacat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006846             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19661:3753
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006846
VERSION     KCXD01006846.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19661:3753"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65328.1"
                     /translation="CTRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          118 c          148 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctactttaag aggtgtccag tgtgacgtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtacctttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagcaatat tacgcagact ctgtgaagga ccgattcacc ctctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tttattactg tacgagagat gtcagaggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006847             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14180:15854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006847
VERSION     KCXD01006847.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14180:15854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..507
     V_segment       138..434
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65329.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       445..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          120 c          154 g          127 t
ORIGIN      
        1 acatggggag gagaggagcc cagccctggg attcccaggt gttttcattt gtgatcagca
       61 ctgaacacag aagactcatc atggagtttg gcctgagctg ggttttcctt gttgctattt
      121 taaaaggtgt ccagggtgag gtgcagctgg tggagtctgg gggctgcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tactggatgt
      241 actgggttcg ccagacacct gagcaggggc tggagtggat ctcagctatt gatagtgctg
      301 gtagtagtac cacatactat gcagactccg tgaagggcag attcaccatc tccagagaga
      361 acgccaaaaa cacactgtat cttcagatgg acagcctgag aactgaggac acggctgtct
      421 attactgtgc gagagttccg ggcctagtgg tatttactgg ttcgcttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006848             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:12007:12093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006848
VERSION     KCXD01006848.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:12007:12093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65330.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       408..419
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          108 a          140 c          137 g          100 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtctccag tcccaggtcc
      121 acctggtgct gtccggggct gaggtgaaga agcctggggc ctcagtgacg gtttcctgcg
      181 gggcctctgg attcaccttc gacacccatg gaatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttattgg tatcacaaac tacgcaaaga
      301 actctcaggg cagagtcaca ataaccgcga acacgtccac aaacacagcc tacatggagc
      361 tgagcagcct gagatctgag gacacggcca tctattattg tgcgagagaa tactgtactt
      421 ctagtagttg cgccgggttc cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01006849             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20089:9709
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006849
VERSION     KCXD01006849.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20089:9709"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65331.1"
                     /translation="CARDRRVESLSWFDVW"
     D_segment       447..452
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          102 a          125 c          155 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agtttcagtt actacttcat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaccagtgg
      301 tgggggtaac acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 ctccaagacc acactgtatc ttcacatgga cagcctgaga cctgaggaca cggctgtcta
      421 ttactgtgca agagatcgac gtgtagagtc gttatcctgg ttcgatgttt ggggcccggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006850             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14621:16136
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006850
VERSION     KCXD01006850.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14621:16136"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..325
     V_segment       8..264
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <256..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65332.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       275..283
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..325
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           79 a           76 c           98 g           74 t
ORIGIN      
        1 acatgggagc ctggggggtc cctgagactc tcctgtgcag cctctggatt cagcttcagt
       61 atctttggca tgcattgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt
      121 atgtcgaatg atggaagtaa gaaatactac acagactctg tgaaggaccg attcaccatc
      181 tccagagaca attccaagaa aatgctatat cttcaaatga acaacctgaa attggaggac
      241 acggccgtgt attattgcgc gagagacgat tttggcagcg gcttagggta ctggggccag
      301 ggagccctgg tgaccgtctc ctcagcc
//
LOCUS       KCXD01006851             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20402:10683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006851
VERSION     KCXD01006851.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20402:10683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..488
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65333.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>491
                     /gene="IGHG"
BASE COUNT          112 a          145 c          138 g           96 t
ORIGIN      
        1 acatgggaca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tccaccttca ccgagttatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttcag tggatgggaa gtgttgatcc tgcatatggt gaaatgataa
      301 acgcagagaa gttccagggc agagtcaccc tgaccgagga cacgtctaca tacacagcct
      361 acatggagct gagcagcctg tcatctgagg acacggccgt gtatttctgt gcgagtggcc
      421 ctagcggcag ctggaacggc tggtacttcg atttctgggg ccctggcacc ccaatcaccg
      481 tctcctcaac c
//
LOCUS       KCXD01006852             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9157:9418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006852
VERSION     KCXD01006852.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9157:9418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65334.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       436..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          103 a          123 c          160 g          113 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg cgcagcctgg
      181 ggggtccctg aaactcccct gcgcagcctc tggattcagc ttcagctact tctacatgag
      241 ctgggtccgc caggctccag gaaaggggct ggagtggatc tcagggattg acagtggtgg
      301 gggtgacaca ttctatgcag actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaggaca ctgtatcttc aaatggacag cctgagacct gaggacacgg ctgtctatta
      421 ctgtgcgagg tctactggga gctacagggg atactttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006853             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6607:9859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006853
VERSION     KCXD01006853.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6607:9859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65335.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          105 a          122 c          160 g          121 t
ORIGIN      
        1 acatggggac ttctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gccggggggg tccctgagac tctcctgcgc agtctctgga ttcagtttca gtcactactt
      241 catgagctgg gtccgccagg ctccagggaa gggactggag tggatctcag ggattaacag
      301 tggtggagat accacacact atgcagactc cgtgaagggc agattcacca tgtccagaga
      361 gaacgccaag aatatagtgt ctcttcaaat ggacggcctg agagctgagg actcggctgt
      421 ctattactgt gcgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtcg cctcagcc
//
LOCUS       KCXD01006854             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15742:19788
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006854
VERSION     KCXD01006854.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15742:19788"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65336.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       442..447
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          109 a          115 c          156 g          116 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggcggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc accttcggaa cctatggcat
      241 gcactgggtc cgccaggctc cagggaaggg cctggagtgg gtgacggtta tatcgaatga
      301 tggaagtaag aaatactacg cggactctgt gaaggaccga ttcagcatct ccagagacaa
      361 ttccaagaac atgctatatc ttcaaatgaa caacgtgaaa ttggaggaca cggccgtcta
      421 ttactgtgtg agagatgcgt ttggtagcgg gcttgactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006855             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19643:13403
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006855
VERSION     KCXD01006855.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19643:13403"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65337.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       409..416
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           94 a          151 c          123 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtaca agaacatgcg gtatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca cctgcaggag
      121 tcgggcccag gactggggaa gccttcagaa accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gtcgtaactg gtggagttgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tagtcttgga agtaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt gtatttctgt gcgagacatt cagaccccgc aactactagc
      421 tggtacttcg atctctgggg ccccggcacc ccaatcacca tctcctcagc c
//
LOCUS       KCXD01006856             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11222:5109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006856
VERSION     KCXD01006856.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11222:5109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65338.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       403..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           90 a          138 c          138 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctccatcagc agtagtacct ggtggaactg ggtccgccag cccccaggga aaggcctgga
      241 gtggatagga tatatcaatg gtgagagtgg tggcacctac tacaatccct ccctcgagag
      301 tcgaatcacc atttcaacag acacgtccac gaaccagttt tccctgaggc tgagctctgt
      361 gaccgccgcg gacacggccg tgtatttctg tgcgagaggt tcctatagtg gtagttatta
      421 cttcaaccgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006857             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18671:19833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006857
VERSION     KCXD01006857.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18671:19833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65339.1"
                     /translation="CASGSRRQPDKW"
     D_segment       403..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..452
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           84 a          138 c          140 g           92 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atcggtggaa ctagtgggag cacctactac cacccctccc tcaagagccg
      301 agtcaccatt tcaacagaca cgtccaagaa ccaggtctcc ctgaagttga tcactgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagtggaagt cggcggcagc cggataaatg
      421 gggccagggc ctcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006858             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9187:23700
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006858
VERSION     KCXD01006858.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9187:23700"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..458
     V_segment       104..397
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65340.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       403..408
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..458
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           99 a           97 c          151 g          113 t
ORIGIN      
        1 acatggggag agatcgagtg ggagtggaca tgagtcagag aaacagtgga tatgtgtggc
       61 agtttctgac cttggtgtct ctctgtttgc aggtgtccag tgtgaggtgc agctggtgga
      121 gtctggaggc ggcttggttc agcctggggg gtccctgaga ctctcctgtg tagcctctgg
      181 attcaccttc agtagtagtg gcatgcactg ggtccgccag gctccaggga aggggctgga
      241 gtggctggct gttgaatcgc atgatggaaa taagaaatac tatgcagact ccgtgaagga
      301 ccgattcacc atctccagag acaattccaa gaacatggta tatcttcaaa tgagcaacct
      361 gaaattggtg gatacggcca tgtattactg tgtgagagat gcctacgggg gcggtttgga
      421 ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01006859             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17926:2492
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006859
VERSION     KCXD01006859.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17926:2492"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65341.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       449..456
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          110 a          118 c          163 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccagtcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggta caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg agtgggtggc actgatatcg
      301 tatgatggag gtaagaaata ctacgcagac tctgtgaagg accgattcac cctctccaga
      361 gacaattccg agaacatcct atatcttcaa atgaacaacc tgaacttggc ggacacggcc
      421 gtgtattttt gtgcgagagt tggagagggt actggtggtg cggaggactt tgacttctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006860             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:11541:16543
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006860
VERSION     KCXD01006860.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:11541:16543"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65342.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       418..424
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          138 c          137 g          100 t
ORIGIN      
        1 acatggggac acaacagcca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctgcaggcg cccgctctga
      121 ggttcagttg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcgaggtt tccggataca ccttcaccga actgtccatc cactgggtgc gacaggcccc
      241 tggaaaaggc cttgagtgga tgggaagtgt tgatcctgaa tatggtgaaa tgataaacgc
      301 agaaaagttc cagggcagag tcaccttgac cgaggacacg tctacaggaa cggcctacat
      361 ggagctgatc agcctgagat ctgaagacac ggccgtgtat tactgtgcga catcacccag
      421 cggcaattgg cttttttggt acttcgattt ttggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01006861             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:17967:9872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006861
VERSION     KCXD01006861.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:17967:9872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..479
     V_segment       104..392
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65343.1"
                     /translation="CVRVVVVSATTAAAAPYDYW"
     D_segment       397..418
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           92 a          142 c          138 g          109 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga ggctcctgtg
       61 gttcttcctc ctgctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatg agtacttact ggtggagctg gatccgccag cccccaggga agggactgga
      241 gtggattgga cagatcaatg gtaatagtgg ttacaccttc tacaacccct ccctcaacag
      301 tcgacttacc atttcaaaag acgcgtccaa gaaccagttc tccctgaaac tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgtgcgtgta gtggtggtgt ctgctacgac
      421 agcagcggct gccccctatg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01006862             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:20683:4150
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006862
VERSION     KCXD01006862.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:20683:4150"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    151..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        151..505
     V_segment       151..444
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65344.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       445..450
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          115 a          119 c          150 g          123 t
ORIGIN      
        1 acatggggac cctgcagctc tgggagagga gcccagccct gtaagtccac agtgttccat
       61 tcggtgatca gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc
      121 cttgttgcta ttttaagagg tgtccggtgt gaggtgcaac tggtggagtc tggaggaggc
      181 ttggttcaac ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt
      241 aagtttggca tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt
      301 atttcgtctg atggaagtaa caaatactac gcaagctctg tgaagagccg attcaccatc
      361 tccagagaca attccaagaa catactatat ctgcaaatga acaacttgaa attggaggac
      421 acggccgtct attactgtgc gagagatgat cttgggaccg gttttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006863             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20812:11646
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006863
VERSION     KCXD01006863.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20812:11646"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65345.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          110 a          141 c          134 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggtaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttactgcgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01006864             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:20252:9678
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006864
VERSION     KCXD01006864.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:20252:9678"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..486
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65346.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          111 a          142 c          138 g           97 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gagggtcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 aactggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctcccctgca
      181 aggcttctgg atacaccctc agcatctcta ccatcagttg ggtacgacag gcccctggac
      241 aagggcttga gtggatgggg gagatcttcc ctcttgttgg taaaacaaaa tacgcacaga
      301 agttccacgg cagagtcacg attaccgcgg acacgtccgc aagtacagcc tacatggagc
      361 tgagcggcct gaaatctgag gacacggccg tctattactg tgcgaaaaga ggtggccacg
      421 gtaccaccac cacgttgtac ttctttgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01006865             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:19261:15790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006865
VERSION     KCXD01006865.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:19261:15790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65347.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           83 a          136 c          142 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtacaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga ccagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tagtcaccgt ctcctcagcc
//
LOCUS       KCXD01006866             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22230:11736
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006866
VERSION     KCXD01006866.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22230:11736"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65348.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          147 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacattg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgctaact ctgtgaagag ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006867             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:16642:19128
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006867
VERSION     KCXD01006867.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:16642:19128"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65349.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          120 a          140 c          136 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtgcttcg atatctgggg ccctggcacc ccgatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01006868             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17274:18759
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006868
VERSION     KCXD01006868.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17274:18759"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..437
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65350.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       452..466
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..517
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          116 a          126 c          146 g          131 t
ORIGIN      
        1 acatgggagc tctgggagag gagacccagc cttgggattt ccagctgtct ccacttggtg
       61 atcagcactg aacacaggag actcgccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtgactat
      241 gccctgagct gggtccgcca ggcttctggg aaaggactgg agtggattgg ctatattaga
      301 agccaatata acaatttcgc gacagaatac gccccatcgg tgaaaggcag attcaccatc
      361 tccagagatg attcaaagaa cacgctattt ctgcaaatga gtagcctgaa aaccgaggac
      421 acggccgtgt attactgcac cacccatttt ggtggtaatt attacttgga ctactttgtc
      481 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006869             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14385:3032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006869
VERSION     KCXD01006869.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14385:3032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..516
     V_segment       141..434
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65351.1"
                     /translation="CTRICCPRDFSSDCHWFDVW"
     D_segment       455..462
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..516
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          102 a          133 c          158 g          125 t
ORIGIN      
        1 acatggggga gctctgagac aggagcctta gccctggatt ccaagaactt ccactttggg
       61 atcagctctg aacacagagg accatggagt tggggctgac ctgggttttc cttgctgctt
      121 ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc tgggggggcc ttggtccagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cacctttggt gattgtggca
      241 tgcactgggt ccgccaggct ccgggaaagg gactggagtg ggtctcatcc attagtaaga
      301 ctggtgaaac cgaatactac actgactccg tgaagggccg attcaccatc tccagaaaca
      361 acgccgagaa ctcgctgtct ctgcaaatga gcagcctgag agccgaggac acggccgtgt
      421 attactgcac tagaatttgt tgtccccgtg attttagcag cgactgtcac tggttcgatg
      481 tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006870             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19294:8203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006870
VERSION     KCXD01006870.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19294:8203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65352.1"
                     /translation="CARDVYGGGLDYW"
     D_segment       442..448
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          116 c          152 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggag tctggaggag gcttggttca
      181 gcctggtggg tccctgagac tctcctgtgc agcctcagga ttcaccttca gcagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagaaatact acgtagactc tttgaaagac cgattcacta tatccagaga
      361 cagctccaag aacttcctat atcttctact gaataacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tctatggtgg ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006871             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16631:18188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006871
VERSION     KCXD01006871.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16631:18188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65353.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          121 c          152 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggcctggggg gtccctgaga ctctcctgtg gagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact cggtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacattcta tatcttcaaa tgaacaacct gaagttggac gacacggccg
      421 tctactactg cgcgagagac gcatttggca gcggctgtga ctactggggc cggggcgtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006872             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24488:6683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006872
VERSION     KCXD01006872.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24488:6683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65354.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       425..432
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          140 c          151 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga gacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgaccc tgcaaatggt gaaataatac
      301 acgcagatag tttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcggcctg agatctgagg acacggccgt gtattactgt gcgagagggg
      421 ggttcggtag cagtgtctgg tccaatctcg tctatggttt ggattcctgg ggccaagggg
      481 tcgccgtcac cgtctcctca gcc
//
LOCUS       KCXD01006873             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9952:8123
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006873
VERSION     KCXD01006873.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9952:8123"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65355.1"
                     /translation="CASGFSGRWILWYFEIW"
     D_segment       422..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          118 a          142 c          135 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctgggactg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc cattcactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgtatatggc gaaatgatag
      301 acgcagagaa gttccagggc agagtcaccc tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gaacagcctg agatctgacg acacggccgt gtattattgt gcgagcggct
      421 ttagcggcag gtggatcctc tggtatttcg aaatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01006874             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14264:7097
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006874
VERSION     KCXD01006874.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14264:7097"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..494
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65356.1"
                     /translation="CARYSDEDHYGDSLPQPPLYYFDFW"
     D_segment       405..421
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT           95 a          149 c          136 g          116 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga ggccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtagct actggaactg gatccgccag ccctcaggga aggggctgga
      241 gtggattgga tatatctatg gtagtactgg gagcaccagt tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaagc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat tccgacgagg atcattacgg
      421 tgactctttg ccccagcccc ccctctatta ctttgacttc tggggccggg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006875             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:18813:17178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006875
VERSION     KCXD01006875.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:18813:17178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65357.1"
                     /translation="CARYSYGNNYFLGFFDYW"
     D_segment       404..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          100 a          139 c          125 g          111 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtac agctgcaaga
      121 gtcgggccca ggactggtga agccttcgga gaccctatcc ctcacctgcg ctgtctccgg
      181 tggctccatc agcagtaact actggacttg gatccgtcag tccccaggga aggggctgga
      241 gtggattggg tatgtctatg gtgacagtgg aagcaccacc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccaattt tccctgaacc taatctctgt
      361 gaccgccgcg gacaccgccg tatattactg tgcgagatat agttacggta acaactactt
      421 cttggggttc tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006876             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:5525:10954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006876
VERSION     KCXD01006876.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:5525:10954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..516
     V_segment       145..438
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65358.1"
                     /translation="CAKRGWAGSWNGGHYFDYW"
     D_segment       450..462
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>519
                     /gene="IGHG"
BASE COUNT          107 a          131 c          164 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtc
      181 cagcctgggg ggtctctgag actctcctgt tcagcctctg gattcacttt cagtagctat
      241 tccatgacct gggtccgcca ggctccaggg aaggggctgg agtgggtctc atacattact
      301 aatggtggtg ttaccacata ctacgcagac tccgtgaagg gccgattcac catctccaga
      361 gacaactcga tggacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc
      421 gtgtattact gtgcgaaaag agggtgggcc ggcagctgga acggggggca ctactttgac
      481 tattggggcc agggagtcct ggtcaccgtc tcctcaccc
//
LOCUS       KCXD01006877             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22327:6605
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006877
VERSION     KCXD01006877.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22327:6605"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65359.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       439..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..503
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          134 c          150 g          113 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcgaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca atacctatgc
      241 tatgcactgg gtccgccagg ctccagggaa ggggctggag tgggtctcag gtattagtag
      301 tggtggtacc acatactacg cagactccgt gaagggccga ttcaccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagcctgaca actgaggaca cggccgtata
      421 ttactgtgcg aagggaggta gcagctcttt ctactggtac ttcgatatcc ggggccctgg
      481 caccccagtc accatctcct cagcc
//
LOCUS       KCXD01006878             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10963:5437
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006878
VERSION     KCXD01006878.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10963:5437"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65360.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..434
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           99 a          145 c          136 g          106 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccgtt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgattgatc ctagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gagggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttataaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01006879             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:12059:10243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006879
VERSION     KCXD01006879.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:12059:10243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65361.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       399..414
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           89 a          142 c          133 g          101 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtaccta ctggagctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tggtggtggg aacaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaagaga cacgtccagg aaccagttct ccctgcagct gaattatgta
      361 accgccgcgg acacggccgt gtattactgt gccagaacta gcggtggctg gtccccctac
      421 tttgactatt ggggccgggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006880             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22047:11548
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006880
VERSION     KCXD01006880.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22047:11548"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65362.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       441..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          114 c          153 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtaaaa tcgtttgatg
      301 gaactaagat atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcctac gggagcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006881             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:18181:20614
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006881
VERSION     KCXD01006881.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:18181:20614"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..465
     V_segment       84..381
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <372..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65363.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       387..404
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          104 a          138 c          119 g          106 t
ORIGIN      
        1 acatgggggg tatcctgtgc cccaccatgg acacgctttg ctacacactc ctgctactga
       61 ccgtcccgtc ctgggccttg tcccaggtca ccttgaagga gtctggtcct gcgctcgtga
      121 aacccacaca gaccctcacg ttgacctgca ccttctctgg gttctcaatc agctctactg
      181 gaagaggtgt gggctggatc cgtcagcccc cagggaaggc cctggaatgg cttgcaacca
      241 tttattggaa tgatagtaaa tactacagca catcgctgaa gagcaggctc accgtctcca
      301 aggacacctc caaaaaccag gtggttctga caatgaccaa catggaccct gtggacacag
      361 ccaaatatta ctgtgcacgg gattactgta gtgggattta ctgcgatgta aatgggcact
      421 actttgacct ctggggccag ggagtcctgg tcgccgtctc ctcagcc
//
LOCUS       KCXD01006882             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:3259:14188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006882
VERSION     KCXD01006882.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:3259:14188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65364.1"
                     /translation="CARDAYGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          149 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggtttggttc
      181 ggcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
      241 gcattcactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaattc tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct caagttggag gacacggccg
      421 tctattactg tgcgagagac gcatatggca gcggctgtga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006883             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10956:10216
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006883
VERSION     KCXD01006883.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10956:10216"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65365.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          118 c          147 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac tttcactacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct gacagttata tcgtttgatg
      301 aaactaagga atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacgcg gccgtgtatt
      421 actgtgtgag agattcttac ggccgaggct ttgactcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006884             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19963:20318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006884
VERSION     KCXD01006884.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19963:20318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65366.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          108 a          139 c          146 g          108 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtct
      121 caggtccagc tggtgcagtc cggggctgag atggagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata cagcttcagc atttatgtca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggc atcttccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cggccacaag cacagcctac
      361 atggacctga gcagcctggg atctggggac acggccgtgt attattgtgc gagaggttac
      421 tgtactggca atggttgtaa ccttactttc aaccggctcg atgtctgggg cccgggagtc
      481 ccggtcaccg tctcctcagc c
//
LOCUS       KCXD01006885             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:21290:14790
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006885
VERSION     KCXD01006885.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:21290:14790"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65367.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       441..446
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          111 c          160 g          116 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttcagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtgg gtctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcggttat atcgagtgat
      301 gaaagtaaga gatactacgg agactctgtg aaggaccgat tcagcatttc cagagacaac
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgcga cagatgcgtt tggtagcggg attgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006886             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19195:18415
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006886
VERSION     KCXD01006886.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19195:18415"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65368.1"
                     /translation="CARVSGIAESSVEYFEFW"
     D_segment       444..453
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..513
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          118 a          122 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag tctccagggg aggggctgga atgggtggca cttatatcgt
      301 atgatggaac taagaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgagcaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagta agcggtatag ctgaaagttc cgttgaatac ttcgagttct
      481 ggggccaggg cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006887             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:9953:13266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006887
VERSION     KCXD01006887.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:9953:13266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..477
     V_segment       111..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65369.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       410..416
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          107 a          136 c          137 g           99 t
ORIGIN      
        1 acatgggggc cacatccctc ccctacagaa gccccagagc acagcacctc accatggact
       61 ggacctggag gatcctcctc ttggtggcag cagctgcagg cgcccgctct gaggttcagt
      121 tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc tcctgcgagg
      181 tttccggata caccttcacc gaactgtcca tccactgggt gcgacaggcc cctggaaaag
      241 gccttgagtg gatgggaagt gttgatcctg aatatggtga aatgataaac gcagaaaagt
      301 tccagggcag agccaccttg accgaggaca cgtctacagg aacggcctac atggagctga
      361 tcagcctgag atctgaagac acggccgtgt attactgtgc gacatcaccc agcggcaatt
      421 ggcttttttg gtacttcgat ttttggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01006888             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7866:8060
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006888
VERSION     KCXD01006888.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7866:8060"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65370.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          125 c          157 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtggagat agcacatact atgcggactc cgtgaacggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01006889             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13197:11036
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006889
VERSION     KCXD01006889.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13197:11036"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65371.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       439..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          112 c          158 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tatttttaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aataaatact acgcagactc tgtgaaggcc cgattcaccg tctccagaga
      361 caattccaag aaaatgttat atcttcaaat ggacaacctg aaattggaag acacggccgt
      421 gtattactgc gcgagagatg tctgggggag gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006890             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6218:10909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006890
VERSION     KCXD01006890.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6218:10909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65372.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       403..413
                     /gene="IGHD6-35"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          138 c          138 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctttggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccatca gcagtaacta ctggagctgg atccgccagt ccccagggaa gggactggag
      241 tggattggac gtatctctgg tagtggtggg agcaccgtct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagatct ccctgaaagt gacctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgacagccg gatatagcag cagtgaaagc
      421 ttctacggtt tggattcgtg gggccaaggg gtcgtcgtct ccgtctcctc agcc
//
LOCUS       KCXD01006891             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:10743:14294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006891
VERSION     KCXD01006891.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:10743:14294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65373.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       435..445
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          118 a          146 c          142 g           99 t
ORIGIN      
        1 acatggggtg catcacacaa caaccacatc cctccccaac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cacctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccgt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg acttgttgat cctgtaaatg gtgaactaat
      301 acacgcagac aagttccagg gcagagtcac catgaccgaa gacacgtcta cagacacagc
      361 ctacatggag ttgagcagcc tgacatctga ggacacggcc atctacttct gtgcgacagg
      421 gaggatcggt accagtggct ggtccaacct cttcaatggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01006892             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11054:15273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006892
VERSION     KCXD01006892.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11054:15273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65374.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       442..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          122 c          156 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggtaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttatttctac
      241 atgagctggg tccgtcaggc tccagggaag gggctggagt ggatctcaag tattgacagt
      301 ggtgggacta ccacaaatta tgcagactcc gtgaggggca gcttcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattattgtg cgagagcgcg cggggtgatc attacatact ttgactcctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006893             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15545:16714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006893
VERSION     KCXD01006893.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15545:16714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..435
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65375.1"
                     /translation="CARGTGAILVYFDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          110 a          123 c          155 g          117 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtcctgt gtgagataaa actggtggag tctgggggcg acttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcctca ggcactacta
      241 tctgacctgg gtccgccagg gtccagggaa ggggctggag tggatctcag gtattaacag
      301 tggtgggagt agcacatact atgcagactc cgtgaaggac agattcacca tctccagaga
      361 caacgccaag aacacactgt atcttcaaat ggacaacctg agagctgagg acacggctgt
      421 ctattactgt gcgaggggga ctggggcgat tcttgtgtac tttgactact ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006894             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:3428:11076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006894
VERSION     KCXD01006894.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:3428:11076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..434
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65376.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       447..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          107 a          142 c          142 g          116 t
ORIGIN      
        1 acatggggac acaattcctt aaattcaggg tccagctcac atgggaaatg ttctctgaga
       61 gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt tcttcctcct cctggtggca
      121 gctcccagat gggtcctgtc ccagctgcag ctgcaggagt cgggcccagg actggtgaag
      181 cctccggaga ccctgtccct cacctgcgct gtctctggtg gctctatcag cagtagttac
      241 tgcagctgga tccgccagac cccagggaag ggactggagt ggattggcta tatatatggg
      301 agtgatagta gtaccaatta caacccctcc ctcaagagtc gagtcaccct gtcagtagac
      361 acgtccaaga accagtgttc cctgaagctg agctctgtga ccgccgcgga cacggccgtg
      421 tatttttgtg cgagttcggg tatagaagtg gttgcctaca gcattgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006895             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:16478:12810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006895
VERSION     KCXD01006895.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:16478:12810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65377.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          105 a          143 c          136 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgtgtatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgac atctgaggac acggccgtct attactgtgc gattggccct agcggcagct
      421 ggaaccactg gtccttcgat atctggggcc ctggcacccc aatcagcatc tcctcagcc
//
LOCUS       KCXD01006896             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18014:12475
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006896
VERSION     KCXD01006896.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18014:12475"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65378.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       438..453
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          104 a          126 c          160 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caggtggtgg agtctggggg cggcttggca
      181 aagcctgggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 gctatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtctc agccattagt
      301 gttggtggta gtacatacta cgcagactcc gtgaggggcc gattcaccat ctccagagac
      361 aactcagaga gcacgctctc cctgcaaatg aacagcctga gtactgagga cacggccgtg
      421 tattactgtg ccaaagggga tacagctaca gtttattacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006897             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23232:10496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006897
VERSION     KCXD01006897.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23232:10496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..443
     V_segment       89..382
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65379.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       393..401
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          102 a          100 c          131 g          112 t
ORIGIN      
        1 acatgggagc acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct
       61 tgttgcgatt ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt
      121 ggttcaaccg gaggggtccc tgagactctc ctgtacagcc tctggattca ccttcagttt
      181 ctatggcttg cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat
      241 ttcgaatgat gaaaataaca aatactacgc agactctgtg aaggaccgat tcaccatttc
      301 tagagacaat tccatgaaca tgctatttct tcaaatgaac aacctgaact tggacgacac
      361 ggccgtctat tactgtgtga gagatgattt aggcagcggc ttagggtcct ggggccaggg
      421 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006898             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9290:17726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006898
VERSION     KCXD01006898.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9290:17726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65380.1"
                     /translation="CAKDAFGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          117 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 atgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgaaagac gcatttggca gcggctgtga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006899             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24860:10029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006899
VERSION     KCXD01006899.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24860:10029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65381.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          104 a          128 c          155 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ttaatggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tcttaacgct
      301 ggtggggata ccacctacta tgcagactcc gtgaagggca gatccaccat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006900             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:18035:19929
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006900
VERSION     KCXD01006900.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:18035:19929"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65382.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          139 c          149 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggag acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg ggttgctcct ggaaatgggg aaataataca
      301 cgcagataac ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgta tattactgtg cgagcgggac
      421 atttgggacc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcagc gtctcctcag cc
//
LOCUS       KCXD01006901             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11193:9879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006901
VERSION     KCXD01006901.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11193:9879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..466
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65383.1"
                     /translation="CARSTSAGNYYSLFFDYW"
     D_segment       406..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>472
                     /gene="IGHG"
BASE COUNT           94 a          144 c          126 g          108 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagc agtgactatt ggagctggat ccgacagtcc ccagggaagg gactagaatg
      241 gattggacat atctctggta gtggtgggaa caccgactac aacccctccc tcatgagtcg
      301 agtcaccatt tcaacagaca cgcccaagaa ccacttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt atttctgtgc gagatcaact agtgctggta attattactc
      421 cctcttcttt gactactggg gccagggagc cctggtcacc gtctccgcag cc
//
LOCUS       KCXD01006902             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8513:2323
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006902
VERSION     KCXD01006902.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8513:2323"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    151..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        151..514
     V_segment       151..442
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65384.1"
                     /translation="CARAGRYTYSYPFDYW"
     D_segment       452..469
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          100 a          160 c          132 g          124 t
ORIGIN      
        1 acatgggggt ctccctcacc acccagctgt ggatctcagt gcttcatttt ctgtccttca
       61 tttctcagtg cttcatttct gtcctccacc acgatggggt caactgccat cctcgccctc
      121 ctcctggctg ttctccaagg agtctgtgcc gaggtgcagc tggtgcagtc tggagcagag
      181 gtgaaaaggc ccggggaatc tctgaggatc tcctgtcaga cttctggata cgactttacc
      241 acttactgga tcagttgggt gcgccagatg cccgggaaag gcctggagtg gatgggaatg
      301 atctatccca gtgattctga tcccagatac agcccgtcct tccaaggcca ggtcaccatc
      361 tcagccgaca agtccatcag caccgcctac cttcattgga gcagcctgaa ggcctcggac
      421 accgccacgt attactgtgc gagagctgga cgatacacct acagttaccc ctttgactac
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006903             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:14460:13960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006903
VERSION     KCXD01006903.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:14460:13960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65385.1"
                     /translation="CARVRGVNIHYFDYW"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           80 a          149 c          137 g           97 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc gcctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactcct ggagctggat ccgccagccc ccaggcaagg gtctggagtg
      241 gattggacat gtcagtggta gtagtgggag caccgactcc cacccctccc tcaagagtcg
      301 agtcaccgtt tcaacagaca cgtccaagcg ccagttctcc ctgaggctga tctctgtgac
      361 cgccgcggac acggccgtct atcactgtgc gagagtccgg ggcgttaaca tccactactt
      421 tgactactgg ggccagggag ccctggtcac cgtcgcctca gcc
//
LOCUS       KCXD01006904             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18973:9132
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006904
VERSION     KCXD01006904.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18973:9132"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65386.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       447..457
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          110 a          131 c          151 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggtcc
      181 agcctggggg gtccctgaga ctctcctgta cagccactgg attcaccttc agtagttttg
      241 gcatgagctg ggtccgccag cctccaggga aggggctgga gtgggtctca tacattagta
      301 atagtggtag tagcacatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagcct gacagctgag gacacggccg
      421 tgtatcactg tgcgaaacat cgtttcagca gctggtcgta tttccttgac ttctggggcc
      481 agggaatcct ggtcgccgtc tcctcagcc
//
LOCUS       KCXD01006905             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16812:3847
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006905
VERSION     KCXD01006905.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16812:3847"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65387.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       414..420
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          138 c          143 g           98 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctccagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaagt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaagtt tccggataca ccttcaccga tttatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatactgta tctgatggag tgatatacgc
      301 agagaacttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgcga gaggtgtgac
      421 agcagacgtc ttcggtttcc tcgggcttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01006906             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23779:17792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006906
VERSION     KCXD01006906.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23779:17792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..510
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65388.1"
                     /translation="CASNLRGNTYTYWRSFDSW"
     D_segment       453..460
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          130 c          156 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgcaattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggagacttg gtccagccgg
      181 gggggtccct gagactctcc tgtgcatcct ctggattcac cttcagtagt tatggcatga
      241 cctgggtccg ccaggctcca gggaaggggc tggagtgggt ctcatacatt agtattggtg
      301 gtagaaatag aaactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 cagagaaaac gctctccctg caaatgaaca gcctgagacc tgaggacacg gccgtgtatt
      421 actgtgcgtc gaacctgcgt ggaaacacct acacttactg gcggtctttt gactcctggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01006907             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9405:16502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006907
VERSION     KCXD01006907.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9405:16502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65389.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       419..425
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          139 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aagtttccgg atacaccttc agcgatttat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgata ctgtatctgg tggagagata
      301 tacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgaccagcct gacatctgag gacacggccg tttattactg tgcgagaggt
      421 gtgacggcag acgtcttcgg tttcctcggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006908             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:15272:20113
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006908
VERSION     KCXD01006908.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:15272:20113"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65390.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       446..451
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          118 c          164 g          113 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaca
      181 gcctgggggg tccctgagac tctcctgtgc agccactgga ttcaccttca gtaggcactg
      241 gatgaactgg gtccgccagg ctccaggaaa ggggctagag tgggtctcag gtattaatag
      301 tggtggggat agaacatact acgcagactc cgtgaagggc cgattcacca tgtccagaga
      361 caactcaaag aacactctct ccctgcaaat gaacagcctg agagcggagg acacggccgt
      421 gtattattgt gtgcaagggg aaatttttgg agtgggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006909             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17713:10513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006909
VERSION     KCXD01006909.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17713:10513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..484
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65391.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       418..431
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..484
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>487
                     /gene="IGHG"
BASE COUNT          117 a          143 c          132 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggattca ccttcaccga tttatccata cactggatac gacaggcccc
      241 tggaaaaggg cttcagtgga tgggaagtgt tgatcctgca tatggtgaaa tgataaacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagccttcat
      361 ggaattgagc agcctgaaat ctgacgacac ggccgtatat tactgtgcga gtggccctag
      421 cggcacctgg atcgactggt ccttcgatgt ctggggccct ggcaccccaa tcaccgtctc
      481 ctcaacc
//
LOCUS       KCXD01006910             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:14360:11683
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006910
VERSION     KCXD01006910.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:14360:11683"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65392.1"
                     /translation="CATGRFGSSVWSTLFYGLDSW"
     D_segment       428..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          142 c          148 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggat acaccttcag tgagatgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatggtg aaataataca
      301 cgcagagaac ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtagcctga catctgagga cacggccgtg tattactgtg cgacagggag
      421 gttcgggagc agcgtctggt ccaccctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006911             276 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:21996:3573
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006911
VERSION     KCXD01006911.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 276)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 276)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:21996:3573"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..274
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..274
     V_segment       7..204
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <196..>243
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65393.1"
                     /translation="CARVDCSGGVCYFDYW"
     D_segment       211..231
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       232..274
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        275..>276
                     /gene="IGHG"
BASE COUNT           69 a           62 c           78 g           67 t
ORIGIN      
        1 acatggggca tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcactt
       61 atatcgtttg atggaagtaa gaaatactac ccagactctg tgaaggaccg attcaccatt
      121 tctagagaca attccaagaa tctgctatat cttcaaatga acaacctgaa attggaggac
      181 acggccgtgt attactgtgc gagagtagac tgtagtggtg gtgtctgcta ctttgactac
      241 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006912             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13266:19727
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006912
VERSION     KCXD01006912.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13266:19727"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65394.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       449..454
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          106 a          125 c          155 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagcg tgaggtgcag ttggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttactactac
      241 atgagttggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattgccgct
      301 gatggggata gcacatacta tgcagactcc atgaaggcca gattcactat ctccagagag
      361 aacgccaaga acacactgca tcttcaaatg gacagcctga gagcagagga cacggctgtc
      421 tattactgtg tgagagatcg acgtgttcag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagtcctga tcaccgtctc ctcagcc
//
LOCUS       KCXD01006913             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:17915:6732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006913
VERSION     KCXD01006913.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:17915:6732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    154..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        154..523
     V_segment       154..445
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <439..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65395.1"
                     /translation="CARLWGDYYALQYYFDYW"
     D_segment       450..464
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT           97 a          160 c          144 g          124 t
ORIGIN      
        1 acatgggggg agtctccctc accacccagc tggggatctc agtgcttcat tttctgtcct
       61 tcatttctca gtgcttcatt tctgtcctcc accacgatgg ggtcaactgc catcctcgcc
      121 ctcctcctgg ctgttctcca aggagtctgt gccgaggtgc agctggtgca gtctggagca
      181 gaggtgaaga ggcccgggga atctctgagg atctcctgtc agacttctgg atacagtttt
      241 gccaactact ggatcgcctg ggtgcgccag atgcccggga aaggcctgga gtggatgggg
      301 atcatctatc ctggtgattc tgacaccaag tacggtccgt ccttcgaagg ccaggtcacc
      361 atctcagccg acaagtccac cagcaccgcc tacctgcagt ggagcagcct gaaggcctcg
      421 gacaccgcca cgtattactg tgcgagactc tggggtgatt attacgcact ccagtactac
      481 ttcgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006914             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23172:7821
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006914
VERSION     KCXD01006914.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23172:7821"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    86..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        86..449
     V_segment       86..379
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65396.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       389..395
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..449
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT          100 a          104 c          139 g          108 t
ORIGIN      
        1 acatggggca caaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt
       61 tgctcttttg aaaggtgtcc agtgtgaggt gaagctggtg gagtctgggg gcggcttggc
      121 aaagcctggg gggtccctga gactctcctg cgcagcctct ggattcagct tcaattatta
      181 ctacatgagc tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattaa
      241 tagtggtggg gaaagcacat actctgcaga ctccgtgaag ggcagattca ccatctccag
      301 agagaacgcc aagaacacgc tatatcttga aatggacagc ctgagaactg aggacacggc
      361 tgtctattat tgtgtgagag atcgacgtgt acagtcgtta tcctggttcg atgtctgggg
      421 cccgggagcc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006915             522 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:14861:15961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006915
VERSION     KCXD01006915.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:14861:15961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..520
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..520
     V_segment       145..444
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>489
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65397.1"
                     /translation="CARGDIPAIEAYYGLDSW"
     D_segment       447..453
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..520
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        521..>522
                     /gene="IGHG"
BASE COUNT          116 a          125 c          157 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattc ccaggcgtct ccacttggtg
       61 atcagcactg aacacaagag actcaccatg gagtttgtac tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag actctcctgt gcaggctctg gattcacctt cagtgactat
      241 gccatgagct gggtccgcca ggcttctggg aaaggactgg agtgggttgg ctatattaga
      301 agcaaatctt acaattacgc gacagaatac gccgcatcgg tgaatggcag gttcaccatc
      361 tccagagatg attcaaagaa caccctacat ctgcaaatga gcagcctgaa aatcgaggac
      421 acggccgtgt attactgtgc tagaggggat ataccggcta tagaggccta ctacggtttg
      481 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006916             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14645:7448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006916
VERSION     KCXD01006916.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14645:7448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65398.1"
                     /translation="CAIGPSGSWNHWSFDIW"
     D_segment       406..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          104 a          143 c          133 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagccc ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attgtccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcctgta tatggtgaaa tgatgttcca
      301 gggcagagtc accatgaccg aggacacgtc tacagacaca gcctacatgg agctgagcag
      361 cctgacatct gacgacacgg ccgtctatta ctgtgcgatt ggccctagcg gcagttggaa
      421 ccactggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01006917             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:15575:19638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006917
VERSION     KCXD01006917.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:15575:19638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65399.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       423..429
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          137 c          150 g           99 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaactg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggagaca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgatcctgca aatggtgaaa taatacacgc
      301 agatggtttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc ggcctgagat ctgaggacac ggccgtgtat tactgtgcga gagggaggtt
      421 cggtagtagc gtctggtcca atctcgtcta tggtttcgat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006918             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:12250:1982
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006918
VERSION     KCXD01006918.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:12250:1982"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65400.1"
                     /translation="CVRDRRVQSLSWFDAW"
     D_segment       451..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          103 a          125 c          160 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgctcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcttgcg cagcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtattaacg
      301 ctggtgggga tagcacatac tatgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa gaacacactg catcttcaag tggacagcct gagagctgag gacacggctg
      421 tctatttctg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gcctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006919             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:16628:6713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006919
VERSION     KCXD01006919.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:16628:6713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65401.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          108 a          126 c          155 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca caccatggag tttgtgctga gctggatttt ccttgttgct
      121 cttttgaaag gtgtccggtg tgaggtgcaa ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcac ttactactac
      241 atgaactggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaacagt
      301 ggtgggcata gcacatacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gaattgagga cacggctgtc
      421 tattactgtg cgagagtagt gggtggtgcc gcaggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01006920             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10810:7358
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006920
VERSION     KCXD01006920.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10810:7358"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65402.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       409..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           98 a          141 c          139 g          100 t
ORIGIN      
        1 acatggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatacag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat ccaccttcac cgagttgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gtatatggtg aaatggtgtt
      301 ccagggcggg gtcaccatga ccgaggacac gtctacagac acaacctact tggagctgaa
      361 cagcctggac tctgaagaca cggccgtgta ttactgtgcg attggcccta gcggcatctg
      421 gaacggctgg tccttcgata tctggggccc tggcacccct gtcactatct cctcagcc
//
LOCUS       KCXD01006921             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:25302:11542
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006921
VERSION     KCXD01006921.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:25302:11542"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..435
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65403.1"
                     /translation="CATVSSGNYYFLHFEYW"
     D_segment       445..461
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          126 a          115 c          149 g          124 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattcccagc tgtctccact tggtgatcag
       61 cactgaacac aggagactcg ccatggagtt tgtactgagc tgggttttcc ttgttgctat
      121 attaaaaggt gtccagagtg aggtacagct ggtggagtct gggggagact tggtccagcc
      181 tggcgggtcc ctgagacttt cctgtgcagc gtctggattg accttcagtg actatgacat
      241 gagttgggtc cgccaggctt ctgggagagg actggagtgg gttggctata ttagaagaaa
      301 aaataaaaat tatgcgacag aatatgccgc atcggtgaaa ggcagattca ccatctccag
      361 agatgattca aagaacacgc tatatctgca aatgagcagc ctgaaaaccg aggacacggc
      421 cgtgtattac tgtgccacag tctctagtgg taattattac ttcctacact ttgaatactg
      481 gggccaggga gtcctggcca ccgtcgcctc agcc
//
LOCUS       KCXD01006922             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:16904:18140
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006922
VERSION     KCXD01006922.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:16904:18140"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65404.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       419..429
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          110 a          145 c          136 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 gggtctcctg caaggtttcc ggatccacct tcaccgattt atccatacac tgggtgcggc
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttga tcctctatat ggtgaaatga
      301 agttccaggg cagagtcacc atgaccgagg acacgtctgc agacacagcc tacatggaac
      361 tgagtagcct gacatctgag gacacggccg tgtattactg tgcgactggc cctagcggca
      421 cctggaacgc ctggtacctc gaaatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01006923             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13851:10050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006923
VERSION     KCXD01006923.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13851:10050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65405.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       423..431
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          111 a          144 c          136 g           91 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcaact acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggaaacacct tcaccgaact gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatga
      301 cgttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggaac
      361 tgagcagcct gacatctgag gacacggccg tgtattactg cgcgattggc cctagtggca
      421 gatggaacga ctggtccttc gacatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01006924             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6492:17744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006924
VERSION     KCXD01006924.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6492:17744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65406.1"
                     /translation="CAREYCTTTDCAGFFDYW"
     D_segment       418..428
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          114 a          130 c          140 g          111 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg atttaccttc gacaactatg gaatcaactg ggtgcggcag
      241 gcccctggac aagggcttga gtggatggga gtggtcatcc cccttgttgg cattatcaat
      301 tatgcagcga acttccaggg cagagtaacg attaacgcgg acacgtccat aaacacagtc
      361 ttcatggagt tcaggagcct gagatctgac gacacggcca tttatttctg tgcgagagaa
      421 tactgtacaa ctactgattg cgccgggttc tttgactact ggggccaggg agtcatggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006925             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20374:5662
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006925
VERSION     KCXD01006925.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20374:5662"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65407.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          114 a          143 c          130 g           92 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttctgga tacaccttaa ccgaccacta cctacactgg gtgcgacagg
      241 ctcctggaaa aggacctgag tggatgggag gtattcaccc tgagtatggt aaagtagact
      301 acacacagaa gttccgagac agagtcacca tcatcgcgga catgtcgaca gagacagtct
      361 acatggagct gagcagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac ttctggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006926             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15474:4964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006926
VERSION     KCXD01006926.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15474:4964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65408.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          139 c          127 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag ccatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga caggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgttt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006927             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13285:18858
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006927
VERSION     KCXD01006927.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13285:18858"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..423
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65409.1"
                     /translation="CAIGPSGRWNGWSFDIW"
     D_segment       434..446
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..498
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          150 c          143 g           93 t
ORIGIN      
        1 acatgggatc aacgcagagt acatgggggc atcacacaac aaccacatcc ctcccctaca
       61 gaagccccag agcacagcac ctcaccatgg actggacctg gaggatcctc ctcttggtgg
      121 cagcagctac aggcgcccac tctgaggtcc ttctggtgca gtctggggct gaggtgaagc
      181 agcctggggc ctcagtgaag gtctcctgca aggtttccgg atacaccctc accgaagtgt
      241 ccactcactg ggtgcgacag gcccccggaa aagggcttga gtgggtggga agtgttgatc
      301 ctgcatatgg tgaaatgaag ttccagggca gagtcaccat gaccgaggac acgtccacag
      361 acacagccta catggaactg agcagcctaa gatctgagga cacggccgtg tattactgtg
      421 cgattggccc ttccggcagg tggaacggct ggtccttcga tatctggggc cctggcaccc
      481 caatcaccat ctcctcagcc
//
LOCUS       KCXD01006928             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:12329:8447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006928
VERSION     KCXD01006928.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:12329:8447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..429
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65410.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       430..434
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          107 a          123 c          154 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcaact tcaattacta ctacatgaac
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattaa cagtggtggg
      301 gatagcacct actatgcgga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaatacac tgtatcttca aatggacagc ctgaaaactg acgacacggc tgtctattac
      421 tgtgcgagag tggtgggtgg tgccgcagga tacttcgact tctggggcca gggcgccctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006929             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17211:8987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006929
VERSION     KCXD01006929.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17211:8987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..464
     V_segment       83..380
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <371..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65411.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       386..403
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          105 a          137 c          118 g          106 t
ORIGIN      
        1 acatggggga atcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggccttgt cccaggtcac cttgaaggag tctggtcctg cgctcgtgaa
      121 acccacacag accctcacgt tgacctgcac cttctctggg ttctcaatca gctctactgg
      181 aagaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccat
      241 ttattggaat gatagtaaat actacagcac atcgctgaag agcaggctca ccgtctccaa
      301 ggacacctcc aaaaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc
      361 taaatattac tgtgcacggg attactgtag tgggatttac tgcgatgtaa atgggcacta
      421 ctttgacctc tggggccagg gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01006930             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:23909:6179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006930
VERSION     KCXD01006930.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:23909:6179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..515
     V_segment       134..427
                     /gene="IGHV3-73"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65412.1"
                     /translation="CARGGEIVDSEIIEDYYGLDFW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..515
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          110 a          117 c          155 g          135 t
ORIGIN      
        1 acatgggggg agccacagcc ccgggattcc cagctgtctc cacttggtca tgaacactga
       61 actcagaaga cgcaccatgg agtttgtgct gagtttgctt ttccttgttg cttttttaaa
      121 aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggtaa agcctggggg
      181 gtccctgaga ctctcttgtg tagtctctgg attctccttc agtaactatg ttatgcattg
      241 ggtccgccag gctccaggaa agggtctgga gtgggtctca cttattagtg gaagtggtgg
      301 taccacagac tacgcagact ctgtgaagag ccgattcacc ctctccagag acaacgccaa
      361 ggaatcgctt tttctgcaaa tgaacagcct aagagccgag gacacggccg tgtattactg
      421 tgctagaggc ggggaaatag tggattcaga gattattgag gattactacg gtttggattt
      481 ctggggccaa ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006931             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13647:7901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006931
VERSION     KCXD01006931.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13647:7901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65413.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       438..443
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          104 a          113 c          158 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggttt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtat ctctggcatg
      241 cactgggtcc gccaggctcc agggcagggg ctggattggg tggcagttga atcgtttgat
      301 ggaggtaaga aatactacgc tgactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgagc aacctgaaat tggaggacac ggccgtgtat
      421 tactgtgtga gagatgccta cgggggcggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006932             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:11031:8826
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006932
VERSION     KCXD01006932.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:11031:8826"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65414.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          117 c          147 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcagttata tcgtctgatg
      301 gaggttacac atactacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caactgaaca acctgaaatt ggaggacacg gccgtttatt
      421 attgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006933             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:21723:12724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006933
VERSION     KCXD01006933.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:21723:12724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65415.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          137 c          129 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggccctgtcc caggtgcttc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc aatagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aaccccgccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006934             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12993:18093
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006934
VERSION     KCXD01006934.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12993:18093"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65416.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          110 a          117 c          159 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgtcag gctccaggaa aggggctaga gtgggtctca actattaata
      301 gtggtgggga taacacatat tacgcaaact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattattg tgttcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01006935             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:4930:5014
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006935
VERSION     KCXD01006935.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:4930:5014"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65417.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       427..438
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           95 a          147 c          145 g          111 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg agacacctct acctactatt ggatcagctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcgatttatc ctggtgattc tgataccaaa
      301 tatagtccgt ccttccaagg ccaggtctcc atctcagccg acaagtccat cagcaccgcc
      361 tacctgcagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggg
      421 gggtggtggg gtgattatcc accctcagac tggctcgatg tctggggccc gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006936             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18805:16842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006936
VERSION     KCXD01006936.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18805:16842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65418.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          113 a          141 c          131 g           91 t
ORIGIN      
        1 acatggggga cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttctggatac accttaaccg accactacct gcactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggtg ttcatcctga atatggtaaa gtagactaca
      301 cacagaagtt ccgagacaga gtcaccatca ccgcggacat gtcgacagag acagcctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgttta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgactac tggggccagg gagccctggt caccgtttcc tcagcc
//
LOCUS       KCXD01006937             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23055:7053
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006937
VERSION     KCXD01006937.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23055:7053"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..491
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65419.1"
                     /translation="CAAGLGGYLLLTEYFEFW"
     D_segment       430..440
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          115 a          137 c          144 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cggcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga accctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaaaaccttc accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ttgcatatga tgaaataata
      301 gacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatttgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgct tactgaatac ttcgagttct ggggccaggg cgccctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01006938             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:15987:8877
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006938
VERSION     KCXD01006938.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:15987:8877"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65420.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       459..466
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          112 a          132 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggtcc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggtggtag taatagatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacagcct gagacctgag gacacggccg
      421 tgtattactg tgcgtcgaac ctacgtggaa acacctacac ttactggcgg tcctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006939             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12931:14459
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006939
VERSION     KCXD01006939.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12931:14459"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65421.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          113 a          110 c          155 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc atttggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtcgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gaaactttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggctg ttatatcgta
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aatatggtat atcttcaaat gaagaacctg aaattggggg acacggccgt
      421 gtattattgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006940             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:2602:10234
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006940
VERSION     KCXD01006940.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:2602:10234"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65422.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       407..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           95 a          131 c          137 g          104 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gttcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctccggaga ccctgtccct cacctgcgct gtatctggtg
      181 gctctatcag cagtagttac tgcagctgga tccgccagac cccagggaag ggactggagt
      241 ggattggcta tatatatggg agtgatagta gtaccaacta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagtgctc cctgaagctg agctctgtga
      361 ccgtcgcgga cacggccgtg tattattgtg cgagttcggg gatagaagtg gttgcctaca
      421 gcattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006941             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18580:4973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006941
VERSION     KCXD01006941.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18580:4973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..452
     V_segment       88..378
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65423.1"
                     /translation="CAAGLGGYLLLTEYFQFW"
     D_segment       394..404
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..452
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>459
                     /gene="IGHG"
BASE COUNT          100 a          123 c          138 g           98 t
ORIGIN      
        1 acatggggcc ccagagcaca gcacctcacc atggactgga cctggaggat cctcctcctg
       61 gtggcggcag ctacaggcgc ccactctgag gtccagctgg tgcagtctgg ggctgaagtg
      121 aagaagcctg gggcctcagt gagggtctcc tgcaaggttt ccggatacac cttcaccgaa
      181 ttatccatgc actggctgcg acaggcccct ggaaaagggc ttgagtggtt gggatgtgtt
      241 gattataaat atgatgaaga aatatacgca gacaatttcc agggcagagt caccatgacc
      301 gaggacacgt ccacagacac agcctacatg gagctgagca gcctgagatc tgaggacacg
      361 gccgtgtatt tctgtgcggc gggccttggg ggatatttac tgcttactga atatttccag
      421 ttctggggcc agggcgccct ggtcaccgtc tcttccgcc
//
LOCUS       KCXD01006942             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23784:5773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006942
VERSION     KCXD01006942.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23784:5773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..469
     V_segment       112..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65424.1"
                     /translation="CARGRIHLQFMDSW"
     D_segment       418..425
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..469
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          107 a          130 c          137 g           97 t
ORIGIN      
        1 atggggaacc acgtccctcc tctaaagaag cccctgggaa cacagcgcat caccatggac
       61 ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc ccaggtccag
      121 ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct ctcctgtaag
      181 gcttctggat acaccttcaa catgtttgcc atcaattggg tgcgacaggc ccctggacaa
      241 gggcttgagt ggatgggagg gaacatccct cttgttgata taacaaagta cgcacagaag
      301 ttccaggaca gagtcacatt taccgcggac acgtccacta gcacagccta catggagctg
      361 agcagcctga gatctgagga cacggccgtt tattactgtg cgagagggag gattcaccta
      421 cagttcatgg actcctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006943             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:21787:6075
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006943
VERSION     KCXD01006943.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:21787:6075"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65425.1"
                     /translation="CATGRIGASGWSNLFNGLYSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          116 a          146 c          143 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgagctaata
      301 cacgcagaca agttccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tctacttctg tgcgacaggg
      421 aggatcggtg ccagtggctg gtccaacctc ttcaatggtt tgtattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01006944             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:23321:19085
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006944
VERSION     KCXD01006944.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:23321:19085"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65426.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       413..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          143 c          132 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggggtc
      121 gggcccaggg ctggtgaagc cttcggagac cctgtccctc acctgcgctg tttctggtga
      181 ctccatcaac agtggctact actggagttg gatccgccaa cccccaggga gggggctgga
      241 gtggattggg tctatcggtg gcagtagtgg cagcacctac tacaacccct ccctcaagag
      301 tcgagtcacc ctttcaaaag acacgtccag gaaccagttc tccctgaaac tgagctctgt
      361 gaccgccgca gacacggccg tttattactg tgcgagaaaa cttccaggtc tccaactaac
      421 cggtttcgat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01006945             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:12633:9482
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006945
VERSION     KCXD01006945.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:12633:9482"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..495
     V_segment       115..406
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65427.1"
                     /translation="CGTGVYYQDEYGNFYVGGDFDYW"
     D_segment       415..435
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>501
                     /gene="IGHG"
BASE COUNT          111 a          136 c          145 g          109 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggcttctg gatacacctt cagcatctct tccatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg ggtggatagg agggatcatc cctcttgttg gtatgacaaa ctacggacag
      301 aagttccagg gcagagtcac aattaccgcg gacacgtcca cgaatacagt cttcatggaa
      361 ctgagcagcc tgacatctga ggacacggcc gtctactatt gtgggacagg ggtatattac
      421 caggatgaat acggtaattt ttatgtcggc ggtgactttg actactgggg ccagggagtc
      481 ctggtcaccg tctccccagc c
//
LOCUS       KCXD01006946             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:5625:6319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006946
VERSION     KCXD01006946.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:5625:6319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65428.1"
                     /translation="CARELCSSSVCAGAFDYW"
     D_segment       424..429
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          113 a          137 c          141 g          105 t
ORIGIN      
        1 acatggggga tcacaaaaca accccatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca
      121 gtcccaggtc cacctggtgc agtccgggac tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtttcctgt aaggcttctg gattcaccct ggacaactat ggtgtcaact gggtgagaca
      241 gacccctgga caaggacttg agtggatggg ggtgatcatc ccccttgttg gtataattaa
      301 ttacgcagag aagttccagg gcacagtcac cattaccgcg gacacgtcca cagacacagc
      361 ctacatggag ttcagcagcc tgagatctga ggacacggcc atctactatt gcgcgagaga
      421 actttgtagc tctagtgtat gtgccggggc ctttgattac tggggccagg gagccctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01006947             292 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22331:8696
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006947
VERSION     KCXD01006947.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 292)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 292)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22331:8696"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..290
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..290
     V_segment       8..225
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>259
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65429.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       231..236
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       242..290
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        291..>292
                     /gene="IGHG"
BASE COUNT           77 a           66 c           81 g           68 t
ORIGIN      
        1 acatggggga ttcacgttca gtaactatgg aatgcactgg gtccgccagg ctccagggaa
       61 ggggctggag tgggtggcag ttatatcgta cgatgaagat aagaaatact acgcagactc
      121 tctgaaggac cgattcacca tctccagaga caattccaag aacatgcttt atcttcaaat
      181 gaacaacctg aaattggagg acacggccgt ttattactgt gcgaggaggc cctggagtgc
      241 agatgctttt gatttctggg gccaaggact cagggtcacc gtctcttcag cc
//
LOCUS       KCXD01006948             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22218:14155
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006948
VERSION     KCXD01006948.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22218:14155"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65430.1"
                     /translation="CARDDSGSGFDYW"
     D_segment       433..441
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          113 a          113 c          153 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatctt
      121 aagaggtgcc cagtgtgagg tgcaactggt ggagtctgga ggaggcttgg tacagcctgg
      181 gggctccctg agactctcct gtgcagcctc tggattcacc ttcagtaact atggcatgca
      241 ctgggtccgc ctggctccag ggaaggggct ggagtgggtg gcagttatgt cgaatgatgg
      301 aaataataga tactacgcag actctgtgaa ggaccgatac accatctcca gagacaattc
      361 gaggaacatg ctgtatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtgtatta
      421 ctgtgcgaga gatgatagtg ggtccggttt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01006949             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24251:7686
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006949
VERSION     KCXD01006949.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24251:7686"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65431.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          114 a          144 c          131 g           92 t
ORIGIN      
        1 acatgggggg catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctacact gggtgcgaca
      241 ggctcctgga aaaggacctg agtggatggg aggtattcac cctgagtatg gtaaagtaga
      301 ctacacacag aagttccgag acagagtcac catcatcgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01006950             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:11283:12082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006950
VERSION     KCXD01006950.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:11283:12082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..287
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65432.1"
                     /translation="CVRDAYGGGWDSW"
     D_segment       239..247
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       248..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           67 a           69 c           84 g           69 t
ORIGIN      
        1 acatggggga ttcaccttca gtacctctgg catgcactgg gtccgccagg ctccagggca
       61 ggggctggag tgggtggcgg ttatatcgtt tgatgatagt aagaaatact acgcagactc
      121 tgtgaaggac cgattcacca tttccagaga caattccaag aacatgctat atcttcagat
      181 gaacaacctg aaattggagg acacggccct ttattactgt gtgagagatg cttacggtgg
      241 tggctgggac tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006951             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:25500:11991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006951
VERSION     KCXD01006951.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:25500:11991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65433.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          116 c          147 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttcttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaca ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaag taagaaatac tacgcagact ttttgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct ccaattggag gacacggccg
      421 tgtattactg tgcgagagat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006952             369 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16998:14585
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006952
VERSION     KCXD01006952.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 369)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 369)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16998:14585"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    13..367
                     /note="immunoglobulin heavy chain variable region"
     V_region        13..367
     V_segment       13..306
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <298..>336
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65434.1"
                     /translation="CARDDSGTGFDYW"
     D_segment       311..319
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       325..367
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        368..>369
                     /gene="IGHG"
BASE COUNT           85 a           81 c          116 g           87 t
ORIGIN      
        1 acatgggagt gtgaagtgca actggtggag tctggaggag gcttggttca gcctgggggg
       61 tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg catgcactgg
      121 gtccgcctgg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa tgatggaatt
      181 aataagtact acgcagactc tgtgaaggac cgatacacca tctccagaga caattcgagg
      241 aacatgctgt atcttcaaat gaacaacctg aaattggagg acacggccgt gtattattgt
      301 gcgagagatg atagtgggac cggttttgac tactggggcc agggagtcct ggtcaccgtc
      361 tcctcagcc
//
LOCUS       KCXD01006953             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19308:16562
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006953
VERSION     KCXD01006953.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19308:16562"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65435.1"
                     /translation="CARDRDTRSGYYGLDSW"
     D_segment       450..458
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..509
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          115 a          120 c          157 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ctcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagata gggatacacg cagcggctat tacggtttgg attcctgggg
      481 ccgaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006954             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17430:21492
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006954
VERSION     KCXD01006954.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17430:21492"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65436.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          111 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01006955             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15536:21262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006955
VERSION     KCXD01006955.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15536:21262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..499
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65437.1"
                     /translation="CVRVDCSGGVCYFDYW"
     D_segment       436..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          107 c          155 g          126 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcagatggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagtagtta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gactgggtga cagttatatc gtatgatgga
      301 agtacgaagt actatgtaga ctctgtgaag gaccgattca ccatctccag agacaattcg
      361 aagaacatgc tatatcttca aatgaacaac ctgaaattgg aggacacggc cgtgtattat
      421 tgtgtgagag tagactgtag tggtggtgtc tgctactttg actactgggg ccagggagtc
      481 ctggtcaccg tctcgtcagc c
//
LOCUS       KCXD01006956             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:17499:20671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006956
VERSION     KCXD01006956.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:17499:20671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65438.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       430..439
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..493
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          135 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg aaaaaccttc actgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ttgcatatga tgaaataatg
      301 gacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcggcgggc
      421 cttgggggat atttactgca tactgaatac ttcgagttct ggggccaggg cgccctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006957             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14475:8685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006957
VERSION     KCXD01006957.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14475:8685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..455
     V_segment       83..373
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <368..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65439.1"
                     /translation="CASNLRGNTYTYWRSFDFW"
     D_segment       398..405
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           98 a          118 c          132 g          109 t
ORIGIN      
        1 acatggggaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
       61 tattttaaga ggtgtccagt gtgaggttca actggtggag tctggaggag acttggtcca
      121 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
      181 catgacctgg gtccgccaga ctccagggaa ggggctggaa tgggtctcat acattagtat
      241 tggtggtggt accacatcct acgcagactc cgtgaagggc cgattcaccg tctccagaga
      301 caactcagag aaaacgctct ccctgcaaat gaacaacctg agacctgagg acacggccat
      361 atattactgt gcgtcgaatc tacgtggaaa cacctacact tactggcggt cctttgactt
      421 ctggggccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006958             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9430:16200
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006958
VERSION     KCXD01006958.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9430:16200"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65440.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          114 a          144 c          130 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctacactg ggtgcgacag
      241 gctcctggaa aaggacctga gtggatggga ggtattcacc ctgagtatgg taaagtagac
      301 tacacacaga agttccgaga cagagtcacc atcatcgcgg acatgtcgac agagacagtc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga cttctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006959             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20312:19002
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006959
VERSION     KCXD01006959.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20312:19002"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65441.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       436..443
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          103 a          116 c          157 g          122 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggt aaagcctggg
      181 gggtccctga gactctcctg cgcggcctct ggattcagct tcagttattt ctacatgagc
      241 tgggtccgtc aggctccagg gaaggggctg gagtggatct caagtattga cagtggtggg
      301 actaccgcta attatgcaga ctccgtgagg ggcagattca tcatctccag agagaacgcc
      361 aagaatacag tgtatcttca aatggacagc ctgagagctg aggacacggc tgtctattat
      421 tgtgcgagag cgcgcggggt gatcattaca tactttgact cctggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006960             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:22316:11179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006960
VERSION     KCXD01006960.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:22316:11179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..481
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65442.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       398..419
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..481
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT           99 a          135 c          137 g          112 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcgaga acatgaagta tctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc agctgcagtt gcaggagtcg
      121 ggcccaggac tgatgaagcc ttcagagacc ctgtccctca gctgcgctgt ctctggtggc
      181 tccataagtg gtaactggtg gagctggatc cgccagcccc cagggaaggg actggactgg
      241 attggacgta tctctggtac tagtggggac accaattaca atccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaagaac cacttctccc tgaagctgaa ctctgtgacc
      361 gccgcggacg cggccgtgta ttattgtgca agagcggatt acgaggatga ttacggttat
      421 catttaggat acaactggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca
      481 gcc
//
LOCUS       KCXD01006961             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:13366:3567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006961
VERSION     KCXD01006961.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:13366:3567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65443.1"
                     /translation="CAAGYSGSWNSWYFDFW"
     D_segment       421..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          138 c          139 g           99 t
ORIGIN      
        1 acatggtggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatacactg gatgcgacag
      241 gcccctggaa aagggcttga gtgggtgggg ggtgttgatc ctgaatatgg tgaaatgaca
      301 cacgtagaga aattccaggg cagagtcacc ttgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtatttctg tgcagccgga
      421 tatagtggca gctggaactc ctggtacttc gatttctggg gtcctggcac cgcaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01006962             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21368:17770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006962
VERSION     KCXD01006962.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21368:17770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..465
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65444.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       418..424
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           85 a          138 c          143 g          101 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg aagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgtctccat cagcactcac tcctggagct gggtccgcca gcccccaggg aagggactgg
      241 agtggattgg acgtatctct ggtagtggtg ggcgcacgga ctacaatccc tccctcaaga
      301 gtcgagtcac cttttcaaca gacacgtcca ggaaccagtt gtccctgagg ctgacgtctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagagt tgaaagcgcc tggtccgtgg
      421 ggtgggatta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006963             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17915:15566
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006963
VERSION     KCXD01006963.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17915:15566"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65445.1"
                     /translation="CVRDSYGRGFDSW"
     D_segment       444..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          121 c          149 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cactacctct
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtggctgac agttatatcg
      301 tttgatgaaa ctaaggaata ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacgcggcc
      421 gtgtattact gtgtgagaga ttcttacggc cgaggctttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006964             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17894:13197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006964
VERSION     KCXD01006964.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17894:13197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65446.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          116 a          111 c          151 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggttca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtatttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcata
      301 tgatgtaagt aagaaatact acgcagacgc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006965             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8365:4746
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006965
VERSION     KCXD01006965.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8365:4746"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65447.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       442..447
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          104 a          125 c          156 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccatt gtgaggtgca gctggtggaa tctgggggcg gcttggcaaa
      181 gcctgggggg tccctaagac tctcctgtgc agcatccgga ttcaccttca gtgaccactg
      241 catgcactgg gtccgccagg cttcagggaa ggggctggag tgggtctcag gtattactta
      301 tgctggtgtt accacatggt acgcagactc cgtgaggggc agattcacca tatccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gtgggaggaa ggcggcacgt ggaccttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcggcc
//
LOCUS       KCXD01006966             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5931:10229
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006966
VERSION     KCXD01006966.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5931:10229"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65448.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       447..459
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          113 a          123 c          154 g          121 t
ORIGIN      
        1 acatgggagc tccaggagag gagcccagcc ctgggattcc caggtgtttt cacttgtgat
       61 cagcactgaa cacagaagac tcatcatgga gattggcctg agctgggttt tccttgttgc
      121 aattttaaaa ggtgtccagg gtgaggtgca gctggtggaa tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccctca gtaactactg
      241 gatgtactgg gttcgccagg caccagggaa ggggctggag tggatctcag ctattaatag
      301 tgttggtgat aacacatact atgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagttc cgggcctagt ggtatttacc ggttcgcttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006967             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15579:13383
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006967
VERSION     KCXD01006967.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15579:13383"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65449.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       406..414
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           94 a          134 c          137 g          110 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcctag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctctcctgca ctgtctctgg
      181 tggctccttc agtggttact actggacctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttatcggtg gtggtagtgg gagcaccgaa tacaacccct ccctcaaaag
      301 tcgagtcacc atgtcaagag acacgtccaa gaatcaattc tccctgaaga tgacctctat
      361 gaccgccgcg gacacggccg tttatttctg tgccagagat gcgggagtgg gagccacaat
      421 cctttattac tatgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01006968             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13046:4464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006968
VERSION     KCXD01006968.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13046:4464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65450.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       405..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..472
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          105 a          135 c          140 g           94 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccttctgg tgcagtctgg ggctgaggtg atgcagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacac cttcaccgat ttgtccatac actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtgggt gggaagtgtt gatcctgaat atggtgaaat gacgttccag
      301 gggagagtca ccatgaccga ggacacgtct acagacacgg cctacatgga gctgagtagc
      361 ctgagatctg aggacacggg cgtgtattac tgtgcgattg gccctagcgg caggtggaac
      421 cactggtcct tcgagatctg gggacctggg accccaatca ccatctcctc agcc
//
LOCUS       KCXD01006969             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7625:9872
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006969
VERSION     KCXD01006969.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7625:9872"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..477
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65451.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       405..422
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          100 a          135 c          136 g          108 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aggccttcgg agaccctgtc cctcacctgc ggtgtctctg
      181 gtggctcctt cagcggtttc tattggagct ggatccgcca gtccccaggg aagggactgg
      241 agtggattgg gtatatcagt gctagtagtg ggagtaccga ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca ataaccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc atgtattact gtgcgagaga gaaatactat agtggtagtt
      421 ataaacacaa ctggttcgat gtctggggcc cgggagtcca ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006970             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12205:14506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006970
VERSION     KCXD01006970.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12205:14506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..494
     V_segment       131..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <416..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65452.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       434..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          107 a          129 c          145 g          115 t
ORIGIN      
        1 acatggggga gcccagccct ggaagtccac agtgttccat tcggtgatca gcacagaaca
       61 cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcaac tggtggagtc tggaggaggc ttggtccagc ctggggggtc
      181 cctgagactc tcctgtacag ccactggatt caccttcagt agttttggca tgagctgggt
      241 ccgccagcct ccagggaagg ggctggagtg ggtctcatac attagtaata gtggtagtag
      301 cacatactac gcagactccg tgaagggccg attcaccatc tccagagaca actcaaagaa
      361 cacgctctcc ctgcaaatga acagcctgac agctgaggac acggccgtgt atcactgtgc
      421 gaaacatcgt ttcagcagct ggtcgtattt ccttgacttc tggggccagg gaatcctggt
      481 cgccgtctcc tcagcc
//
LOCUS       KCXD01006971             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:14167:13939
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006971
VERSION     KCXD01006971.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:14167:13939"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65453.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          121 a          138 c          134 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccaggtg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01006972             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10165:12382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006972
VERSION     KCXD01006972.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10165:12382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    164..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        164..518
     V_segment       164..457
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <449..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65454.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       463..468
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          109 a          131 c          164 g          116 t
ORIGIN      
        1 acatgggatc aacgcagagt acatggggga gctctgggag aggagcccag ccccagaatt
       61 cccaggtgtt tctgttcggc gatcagcact aaacacagaa cacaccatgg agtttgtgct
      121 gagctgggtt ttccttgttg ctcttttgaa aggtgtccat tgtgaggcgc acctggtgga
      181 gtctgggggc ggcttggcaa agcctggggg gtccctaaga ctctcctgtg aagcctccgg
      241 gttcaccttc agtgaccact gcatgcactg ggtccgccag gcttcaggga gggggctgga
      301 gtgggtctca ggtattactt atactggtgt taccacatgg tacgcagact ccgtgagggg
      361 cagattcacc atctccagag agaacgccaa gaacacactg tatcttcaaa tggacagcct
      421 gagagctgag gacacggctg tctattactg tgtgggagga aggcggcacg tggaccttga
      481 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006973             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21676:14466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006973
VERSION     KCXD01006973.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21676:14466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65455.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       439..445
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          119 a          141 c          145 g          100 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaaatgaag aagcctgggg cctcagttag
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg atgtgtcgat cctgcacaag gtgaaataat
      301 atacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 cttcatggag ttgagcagcc tgagatctga ggacacggcc gtgtatttct gtgcgaaagg
      421 ggggttcgga accagcgtct ggtccaacct cttctacggt ttggattcct ggggccaagg
      481 ggtcgtcgtc accgtctctt cagcc
//
LOCUS       KCXD01006974             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:19806:7430
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006974
VERSION     KCXD01006974.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:19806:7430"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65456.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 caattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactatg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006975             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:15108:17442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006975
VERSION     KCXD01006975.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:15108:17442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65457.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       441..445
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          113 a          120 c          148 g          114 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgctgctatt
      121 ttaagaggtg tccagtgtga ggtccacctg gtggagtctg gaggaggctt cattcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccctcagtac ctatggcata
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat atcgtctgat
      301 ggaagtagga aatactacgc agactctttg aaagcccgat tcaccatatc cagagacaac
      361 tccaagaaca tagtatatct tcaattgaac aacctgaaat tggaggacac ggccgtatat
      421 tactgtgcga gagatgtgta tggctcgggg cttgactact ggggccaggg agtcctgctc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006976             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:26341:16253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006976
VERSION     KCXD01006976.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:26341:16253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..465
     V_segment       111..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65458.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       413..419
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT          109 a          103 c          141 g          114 t
ORIGIN      
        1 acatggggac agtgttccat tcggtgatca gcacagaaca cagaggactc accatgaagt
       61 ttgggctgag ctgggttttc cttgttgcta ttttaagagg tgtccagtgt gaggtgcacc
      121 tggtggagtc tggaggaggc ttggttcagc ctggggggtc cctgagactc tcctgtgaag
      181 cctctggatt caccttcagt agttatggca tgcactgggt ccgccaggct ccagggaagg
      241 ggctggagtg ggtggcagtt atatcgtatg atgtaagtaa gaaatactac gcagacgctg
      301 tgaaggaccg attcaccatc tccagagaca attccaagaa caccctatat cttcaaatga
      361 acaacctgaa attggaggac acggccgtgt attactgtgg gagagatgat aatggggtgc
      421 ttatcgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01006977             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10332:12823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006977
VERSION     KCXD01006977.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10332:12823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..481
     V_segment       128..421
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65459.1"
                     /translation="CAKTYYSGSLEYW"
     D_segment       425..440
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..481
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>484
                     /gene="IGHG"
BASE COUNT          104 a          148 c          126 g          106 t
ORIGIN      
        1 acatggggac agtgagtctc cctcaccgca cagctgggat ctcagtgctt catttctgtc
       61 ctccaccacg atggggtcaa ctgccatcct cgccctcctc ctggctgttc tccaaggagt
      121 ctgtgccgag gtgcagctgg tgcagtctgg aacagaggtg aaaaggcccg gggagtctct
      181 gaggatctcc tgtcagacct ctggatacaa ctttcccagc agctggatca cctgggtgcg
      241 ccagatgccc gggaaaggcc tggagtggat ggggaccatc tatcctgctg attctaatgc
      301 caaatacaac ccgtccttcc aaggccacgt cactatctca gtcgacaagt ccatcagcac
      361 cacctacttg cagtggagca acctgaaggc ctcggacacc gccacgtatt actgtgccaa
      421 aacctactat agtggtagtt tggaatactg gggccaggga gtcctggtca ccgtctcctc
      481 aacc
//
LOCUS       KCXD01006978             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:20354:13154
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006978
VERSION     KCXD01006978.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:20354:13154"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65460.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       412..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           91 a          140 c          144 g          103 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcggga
      121 gtcgggccca gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc accagtagta attggtggag ctggatccgc cagtccccag ggaagggact
      241 ggaatggatt gggggtgtct atggtagtgg tgggaatacc gaatacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aggacacgtc caagaaccag ttctccctga agctgaactc
      361 tgtgaccgcc gcggacaccg ccgtgtatta ctgcacgaga gaatggggcg ctatagcggc
      421 agttgggcct gtccttgcct cctggggcca gggtgtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006979             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10380:3538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006979
VERSION     KCXD01006979.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10380:3538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65461.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       434..444
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          146 c          143 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctccccaaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccgtc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga cttgttgatc ctgtaaatgg tgaactaata
      301 cacgcagaca agtgccaggg cagagtcacc atgaccgaag acacgtctac agacacagcc
      361 tacatggagt tgagcagcct gacatctgag gacacggcca tctactactg tgcgacaggg
      421 aggatcggta ccagtggctg gtccaacctc ttcaatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01006980             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:8831:10279
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006980
VERSION     KCXD01006980.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:8831:10279"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65462.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       431..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          115 a          133 c          149 g           98 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcatag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagttggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ttcaccgatt tatccatgca ctgggtgcga
      241 caggccccag gaaaagggct tgagtggatg ggaagtgttg atcctgtata tggtgaaata
      301 attgtcgcag agaatttcca ggacagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctggaatct gaggacacgg ccgtgtatta ctgtgcgaaa
      421 gggaggagtg gtggtgtctg gccgagctcc ttcgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01006981             339 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21630:4780
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006981
VERSION     KCXD01006981.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 339)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 339)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21630:4780"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..337
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..337
     V_segment       7..276
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <268..>306
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65463.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       282..288
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..337
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        338..>339
                     /gene="IGHG"
BASE COUNT           79 a           86 c           95 g           79 t
ORIGIN      
        1 acatggggag gcttggttca gcctgggggg tccctgagac tctcctgtac agcctctgga
       61 ttcaccttca gtacctctgg catgcactgg gtccgccagg ctccagggaa ggggctggag
      121 tggctgacag ttatatcgta tgatgaaact aagaaatact acgcagactc tgtgaaggac
      181 cgattcacca tctccagaga caattccaag aacatggtat atcttcaaat gaacaacctg
      241 aaattggagg acgcggccgt gtattactgt gcgagagatt cttacggtcg aggctttgac
      301 tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006982             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24615:14037
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006982
VERSION     KCXD01006982.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24615:14037"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..509
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65464.1"
                     /translation="CARVSGHTEGTVENFDYW"
     D_segment       436..442
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          114 a          113 c          159 g          125 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgctgct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agcttcagtg gctttggcat
      241 acactgggtc cgccaggctc ctgggaaggg gctggagtgg gtgtcactta tatcgtatga
      301 tggaagtaag aaatactacg cagactctgt gaaggaccga ttcaccttgt ccagagacaa
      361 ttccaagaac atggtatatc ttcacatgaa caacctgaaa ttggaggaca cggccgtgta
      421 tttctgtgcg agagttagtg ggcatacaga ggggacagtt gaaaactttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006983             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:21352:22076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006983
VERSION     KCXD01006983.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:21352:22076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65465.1"
                     /translation="CVRDAYGSGWDSW"
     D_segment       448..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          114 c          156 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtacctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgtt
      301 tgatgatagt aagaaatact actcagactc tgtgaaggac cgattcacca tttccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gtgagagatg cttacggtag tggctgggac tcctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01006984             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:17850:14389
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006984
VERSION     KCXD01006984.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:17850:14389"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..454
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65466.1"
                     /translation="CASGSRRQPDKW"
     D_segment       405..412
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..454
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           86 a          137 c          141 g           92 t
ORIGIN      
        1 acagggggat gctctctgag agtcacggac ctcctgtgca agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat atatcggtgg aactagtggg agcacctact acaacccctc cctcaagagc
      301 cgagtcacca tttcaacaga cacgtccaag aaccaggtct ccctgaagtt gatcactgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagtggaa gtcggcggca gccggataaa
      421 tggggccagg gcctcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01006985             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12418:17645
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006985
VERSION     KCXD01006985.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12418:17645"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65467.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       445..450
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          112 c          155 g          119 t
ORIGIN      
        1 atggggagct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 tttttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagctttggc
      241 attcactggg tccgccagac tccagggaag gggctggagt gggtggcagt tatatcgtat
      301 gatgaaacta agacatacta cgcagactct gtgagggacc gattcaccat ctccagagac
      361 aattccaaaa acatggtgta tcttcaaatg aacaacctga aattggagga cacggccgta
      421 tattactgtg cgagagatgt caggggaacg gggtttgact actggggcca gggagtcctg
      481 gtcaccgtct cgtcagcc
//
LOCUS       KCXD01006986             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:15208:5815
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006986
VERSION     KCXD01006986.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:15208:5815"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65468.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          112 c          158 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg cgcgagagac gattttggca gcggcttagg gtactggggc cagggagccc
      481 tggtgaccgt ctcctcagcc
//
LOCUS       KCXD01006987             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22289:7587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006987
VERSION     KCXD01006987.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22289:7587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65469.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       435..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          142 c          143 g           97 t
ORIGIN      
        1 acatggggac acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccaac tggtgcagtc tggggctgaa atgaagaagc ctggggcctc agttagggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gtcgatcttg cacaaggtga aataatacac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtccacaga cacagccttc
      361 atggagttga gcagcctgag atctgaggac acggccgtgt atttctgtgc gaaagggggg
      421 ttcggaacca gcgtctggtc caacctcttc tacggcttgg attcttgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01006988             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8912:19513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006988
VERSION     KCXD01006988.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8912:19513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65470.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          111 c          155 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc aggagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatat tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01006989             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22308:13806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006989
VERSION     KCXD01006989.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22308:13806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..496
     V_segment       127..420
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65471.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       422..428
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          140 c          145 g           99 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct ccagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccacctggt gcagtctggg gctgaagtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaagtttc cggatacacc ttcaccgatt tatccatgca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaggtgttg atactgtatc tgatggagtg
      301 atatacgcag agaacttcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg agctgagcag cctgagatct gaggacacgg ccgtttatta ctgtgcgaga
      421 ggtgtgacag cagacgtctt cggtttcctc gggcttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01006990             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22272:19213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006990
VERSION     KCXD01006990.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22272:19213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..476
     V_segment       110..403
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65472.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       414..426
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          103 a          112 c          143 g          120 t
ORIGIN      
        1 acatggggag gtgttttcat ttgtgatcag cactgaatac agaagactca tcatggagtt
       61 tggcctgagc tgggttttcc ttgctgctat tttaaaaggt gtccagggtg aggtgcagct
      121 ggtggaatct gggggcggct tggcaaagcc tggggggtcc ctgagactct cctgtgcagc
      181 ctctggattc accctcagta actactggat gtactgggtt cgccaggcac cagggaaggg
      241 gctggagtgg atctcagcta ttaacagtgt tggtgatacc acatactatg cagactccgt
      301 gaagggcaga ttcaccatct ccagagagaa cgccaagaac actctgtatc ttcaaatgga
      361 cagcctgaga gctgaggaca cggctatcta ttactgtgcg agagttccgg gcctagtggt
      421 atttaccggt tcgcttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01006991             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:28261:11909
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006991
VERSION     KCXD01006991.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:28261:11909"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65473.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..497
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>503
                     /gene="IGHG"
BASE COUNT          117 a          117 c          148 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 ttagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggac gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctctcca gcc
//
LOCUS       KCXD01006992             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15176:11266
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006992
VERSION     KCXD01006992.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15176:11266"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65474.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           84 a          139 c          137 g          103 t
ORIGIN      
        1 acatggggga tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttttcggtg gtagtggtgg gagcacctac tacaaatcct ccctccagag
      301 tcgcgtcacc atttcaaccg acacgtccaa gaaccagttc tccctaatac tgacctctgt
      361 gaccgccgcg gacacggccc tctattactg tgcgaggggg aatatagcag cgactggcat
      421 tgactactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01006993             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:8599:19327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006993
VERSION     KCXD01006993.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:8599:19327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..504
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65475.1"
                     /translation="CARVDCSGGVCYFDYW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>508
                     /gene="IGHG"
BASE COUNT          114 a          117 c          156 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggtgt tccttgttgc
      121 tattttaaga ggtgcccagt gtgaggtgca actggtgggg tctggcggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttta gtagccatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcaa ttatatcgta
      301 tgatggaaat gagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat aaacaacctg aaattggagg acacggccat
      421 gtattactgt gcgagagtgg actgtagtgg tggtgtctgc tactttgact attggggcca
      481 gggagtcctc gtcaccgtct cctcggcc
//
LOCUS       KCXD01006994             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:2406:12318
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006994
VERSION     KCXD01006994.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:2406:12318"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65476.1"
                     /translation="CAREWIQWTQLVSGLDSW"
     D_segment       439..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..512
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          119 a          113 c          161 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gatggaggag tctggaggag gcttggttca
      181 gcctgggggg tcgctgagac tctcctgtgt agcctctgga ttcagtttca atacctatgg
      241 catgcactgg gtccgccagg ctccagggga ggggctggag tgggtggcag tcatatcgtt
      301 tgatggaaat aagaaatact acgcagactc tgtgaaggac cgactcacca tctccagaga
      361 caattccaag agtacgctat atcttcaaat gaacaacctg aaattggagg acacggccat
      421 atattactgt gcgagggagt ggatacagtg gacacagtta gtgagcggtt tggattcctg
      481 gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01006995             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:13596:12427
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006995
VERSION     KCXD01006995.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:13596:12427"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65477.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           96 a          138 c          135 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact ggagctggat ccgccagtcc ccaggaaagg gactggagtg
      241 gattggacgt atttctggga gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccttt tcaacagaca cgtccaagaa cgagatctcc ctgaaagtga cctctgtgac
      361 cgccgcggac acggccgtat attattgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt catcgtcacc gtctcctcag cc
//
LOCUS       KCXD01006996             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12561:7873
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006996
VERSION     KCXD01006996.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12561:7873"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65478.1"
                     /translation="CAREYCTSDSCAGFFDSW"
     D_segment       418..429
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          117 a          139 c          135 g          104 t
ORIGIN      
        1 acatggggat cacaaaacaa ccacatccct cctctaaaga agcccctggg agcacagctc
       61 atcaccatgg actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag
      121 tcccaggtcc acttggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtttcctgca aggcttctgg attcaccctc gacaactatg gaatcaactg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga gtgatcatcc cccttgtcgg tatagtgaac
      301 tacgtagaga acctccaggg cagagccacg ataaccgcgg acacgtcaac aaacacagtc
      361 tacatggaac tgaacagcct gagatctgac gacacggcct cctattactg tgcaagagaa
      421 tactgtactt ctgattcttg cgccggattc tttgactcct ggggccaggg agtcctggtc
      481 accgtctctt cagcc
//
LOCUS       KCXD01006997             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19866:19787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006997
VERSION     KCXD01006997.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19866:19787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65479.1"
                     /translation="CVRDDYGSGLGSW"
     D_segment       441..453
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          116 c          153 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttta gaggtgtcca gtgtgaagtc caactggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgcg actctcctgt gcagcctctg gattcacctt cactactttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 aatgatggaa gtaagaaata ttacgcagac tctgtgaagg accgattcac cttgtccaga
      361 gacaatacca agaacatgct atatattcaa atgaacaacc tgaaattgga ggacacggcc
      421 atgtattact gtgtgagaga tgactacggt agcggcctcg ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01006998             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:17439:12624
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006998
VERSION     KCXD01006998.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:17439:12624"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..502
     V_segment       122..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65480.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       422..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>508
                     /gene="IGHG"
BASE COUNT          114 a          138 c          145 g          111 t
ORIGIN      
        1 acatgggaca cataacaacc atgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccac ctggtgcagt ccggggctga ggtgaagaag cctggggcct cagtgaagct
      181 ctcctgcaag acttctggat acaccttcag catctctgcc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgggt ggatgggagg gatcatccct cttgttggtg tgacaaacta
      301 cgaacagaag ttccagggca gagtcacgat taccgcggac acgtccacga atacagtctt
      361 catggaactg agcagcctga gatctgagga cacggccgtc tactattgtg cgacaggggt
      421 atattaccag gatgaatacg gttattttta tgtcggcggt gactttgact actggggcca
      481 gggagtcctg gtcaccgtct ccccagcc
//
LOCUS       KCXD01006999             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22725:2486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01006999
VERSION     KCXD01006999.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22725:2486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65481.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..443
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..502
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          102 a          127 c          160 g          115 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggcaaag
      181 ccgggggggt ccctgagact ctcctgcgca gcctctggtt tcagcttcag tttctactat
      241 atgacctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattgacact
      301 ggtgggggta acacctacta tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga agacacagta tcttcaaatg gacagcctga gaactgagga cacggctgtc
      421 tattactgtg cgagagtagt gggcggtgcc gccggatact tcgacttctg gggccagggc
      481 gccctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007000             436 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:7458:15866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007000
VERSION     KCXD01007000.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 436)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 436)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:7458:15866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    80..434
                     /note="immunoglobulin heavy chain variable region"
     V_region        80..434
     V_segment       80..371
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <365..>403
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65482.1"
                     /translation="CVTGRRHVDLDYW"
     D_segment       379..384
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       393..434
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        435..>436
                     /gene="IGHG"
BASE COUNT           90 a          107 c          137 g          102 t
ORIGIN      
        1 acatgggaac acagaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
       61 tttgaaaggt gcccattgtg aggtgcagtt ggtggagtct gggggcggct tggcaaagcc
      121 tggggggtcc ctaagactct cctgtgcagc ctccggattc accttcagtg accactgcat
      181 gcactgggtc cgccaggctt cagggaaggg gctggagtgg gtctcaggta ttacttatag
      241 gggtgttacc acatggtacg cagactccgt gaggggcaga ttcaccatct ccagagagaa
      301 cgccaagaac acattgtatt ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      361 ttactgtgtg acaggacggc ggcacgtgga ccttgactac tggggccagg gagtcctggt
      421 caccgtctcc tcagcc
//
LOCUS       KCXD01007001             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:9375:18372
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007001
VERSION     KCXD01007001.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:9375:18372"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65483.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          112 c          157 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggcggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagt agtggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtggct ggctgttgaa tcgcatgatg
      301 gaaataagaa atactatgca gactccgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat ggtctttctt caaatgagca acctgaaatt ggtggatacg gccatgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007002             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:23890:12112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007002
VERSION     KCXD01007002.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:23890:12112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65484.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          132 c          136 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtggaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagg tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcacctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctct tcagcc
//
LOCUS       KCXD01007003             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19318:13047
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007003
VERSION     KCXD01007003.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19318:13047"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65485.1"
                     /translation="CAKHRFSSWSYFLDFW"
     D_segment       446..456
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          109 a          131 c          151 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgga gtctgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca actggtggag tctggaggag gcttggtcca
      181 gcctgggggg tccctgagac tctcctgtac agccactgga ttcaccttca gtagttttgg
      241 catgagctgg gtccgccagc ctccagggaa ggggctggag tgggtctcat acattagtaa
      301 tagtggtagt agcacatact acgcagactc cgtgaagggc cgattcacca tctccagaga
      361 caactcaaag aacacgctct ccctgcaaat gaacagcctg acagctgagg acacggccgt
      421 gtatcactgt gcgaaacatc gtttcagcag ctggtcgtat ttccttgact tctggggcca
      481 gggaatcctg gtcgccgtct cctcagcc
//
LOCUS       KCXD01007004             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18704:17864
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007004
VERSION     KCXD01007004.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18704:17864"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65486.1"
                     /translation="CARNRFMGVRVLAYW"
     D_segment       402..406
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           95 a          137 c          130 g          103 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtcca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcggttacta ctggaactgg atccgccaac caccagggaa gggcctggag
      241 tggattgggt atatcgctgg tagtagtggg agcaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag agccaattct ccctgaagct gaactctgtg
      361 accgccgcgg acacggccat ctattactgt gcgagaaata gatttatggg tgtaagggtt
      421 cttgcctact ggggccaggt agtcctggtc gccgtctcct cagcc
//
LOCUS       KCXD01007005             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12936:6668
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007005
VERSION     KCXD01007005.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12936:6668"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65487.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          109 a          142 c          137 g           90 t
ORIGIN      
        1 acatggggga cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcttt ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaattgag
      361 cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggaccta ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01007006             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:23961:9115
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007006
VERSION     KCXD01007006.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:23961:9115"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65488.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          122 a          139 c          135 g           94 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaaggataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007007             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:11750:8740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007007
VERSION     KCXD01007007.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:11750:8740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65489.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       446..452
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          115 a          114 c          151 g          116 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgctgt
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggagact tggttcagcc
      181 gggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actatggcat
      241 acactgggtc cgccaggctc cagggaaggg gctggactgg gtggcagtta tatcgtctga
      301 tggaagtaag acatactacg caaagtctgt gaaggaccga ttcaccatat taagagacaa
      361 ttccaacagc atgctctatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtcta
      421 ttactgtgcg agagacgata tgggaagtgg ctttgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01007008             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19529:17110
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007008
VERSION     KCXD01007008.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19529:17110"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65490.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           97 a          134 c          129 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctatgg tagtactggg agcaccggct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagtt gaactctgtg
      361 atcgccgcgg acaccgccgt gtattactgt gcgagatatg gagatgatag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007009             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:23697:19807
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007009
VERSION     KCXD01007009.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:23697:19807"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..506
     V_segment       140..433
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65491.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       444..460
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          111 a          119 c          153 g          125 t
ORIGIN      
        1 acatggggct aggagaggag cccagccctg ggattcccag gtgttttcat ttgtgatcag
       61 cactgaacac agaagactca tcatggagtt tggcctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagggtg aggtgcaact ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgtgtagc ctctggattc accctcagta actactggat
      241 gtactgggtt cgccaggcac cagggaaggg gctggagtgg atctcagcta ttaatagtgt
      301 tggtgatagc acatactatg cagactccgt gaagggcaga ttcaccatct ccagagagag
      361 cgccaagaac acactatatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagtaccgg gcctagtggt atttactgct tcacttgact actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007010             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:6297:15647
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007010
VERSION     KCXD01007010.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:6297:15647"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..491
     V_segment       119..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65492.1"
                     /translation="CAKRGGHGTTTTLYFFDYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          143 c          138 g           98 t
ORIGIN      
        1 acatggggat aacaaccacg tccctcctct aaagaagccc ctgggaacac agctcatcac
       61 catggacttg acctggaggg tcctctttgt ggtggcagca gctacaggtg cccagtccca
      121 ggtccaactg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaagctccc
      181 ctgcaaggct tctggataca ccctcagcat ctctaccatc agttgggtac gacaggcccc
      241 tggacaaggg cttgagtgga tgggggagat cttccctctt gttggtaaaa caaaatacgc
      301 acagaagttc cacggcagag tcacgattac cgcggacacg tccgcaagta cagcctacat
      361 ggagctgagc ggcctgaaat ctgaggacac ggccgtctat tactgtgcga aaagaggtgg
      421 ccacggtacc accaccacgt tgtacttctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007011             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13139:7987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007011
VERSION     KCXD01007011.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13139:7987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..318
     V_segment       8..256
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65493.1"
                     /translation="CASNSITSGPDYW"
     D_segment       262..268
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       282..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           65 a           98 c           85 g           72 t
ORIGIN      
        1 acatggggga gaccctgtct ctcacctgcg ctgtctctgg tggctctatc agcggtaact
       61 actggagctg gatccgccgg gccccaggga agggactgga gtggattgga tatatctacg
      121 gtagtgattt taccaccaac tacaacccct ccctcaagag tcgagtcacc ctgtcagcag
      181 atacgtccaa gaaccagctc tccctgaacc tggcctctgt gaccgccgcg gacacggccg
      241 tctatttctg tgccagtaat agtataacat ctggtccaga ttactggggc cggggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007012             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16094:16829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007012
VERSION     KCXD01007012.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16094:16829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..496
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65494.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          106 a          117 c          157 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtagccttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag tctacggtac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaatgccaa gaacacgctg tttcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tttattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcggcc
//
LOCUS       KCXD01007013             517 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:22713:16470
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007013
VERSION     KCXD01007013.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:22713:16470"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..515
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..515
     V_segment       140..429
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>484
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65495.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       467..473
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..515
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        516..>517
                     /gene="IGHG"
BASE COUNT          111 a          123 c          161 g          122 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtatttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcacct ggtgcagtct gggggcggct tgacaaagcc
      181 gggggggtcc ctgagactct cctgtgcagc ctccggattc accttcagtg actactatat
      241 ggactgggtc cgccaggctc cagggaaggg gctggagtgg gtctcacgaa tcggtcatga
      301 tggtggtagc acatggtacg cagactccgt gaagggcaga tttaccattt ccagagagaa
      361 tgccaagaac acactgtttc ttcaaatgga cagcctgaga agtgaggaca cagccgtata
      421 ttactgtgcc agagagcggt ttgggggaat tggggtaatt atcttcaact ggatcgatgt
      481 ctggggcccg ggagtcctgg tcaccgtccc ctcagcc
//
LOCUS       KCXD01007014             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:9647:4171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007014
VERSION     KCXD01007014.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:9647:4171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65496.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       439..443
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          113 c          156 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtatatctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      301 ctgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcaaa aaacatggtt tatcttcaaa tgaacaacct gaagttggag gacacggccg
      421 tgtatttctg tgtgagagat gccttcgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007015             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:21270:10152
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007015
VERSION     KCXD01007015.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:21270:10152"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65497.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       451..457
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          118 a          116 c          149 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctgttttaa gaggtgtcca gtgtgaggtc cagctggtgg agtctggagg agacttggtt
      181 cagcctgggg ggtccctcag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatggaa gtaagacata ctacgcaaac tctgtgaagg accgattcac catattaaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 ctctattact gtgcgagaga cgatatggga agtggctttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007016             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17179:18117
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007016
VERSION     KCXD01007016.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17179:18117"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..326
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65498.1"
                     /translation="CARMDCTGGVCYFDYW"
     D_segment       270..283
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       284..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           77 a           78 c           93 g           80 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttatgg
       61 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtt
      121 tgatggaagt aagaaatact acgcagactc tatgaaggac cgattcacca tctccagaga
      181 caattccaag aacatgctag atcttcaaat gagcaacctg aaattggagg acacggccgt
      241 ctattactgt gcgagaatgg attgtactgg tggtgtctgc tactttgact actggggcca
      301 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007017             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17840:21582
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007017
VERSION     KCXD01007017.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17840:21582"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65499.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       415..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT          116 a          144 c          129 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc acctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg ctacaccttc gccgaattgc ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggttttgctt ctatatatgg tgaaataata
      301 catacagaga gattccaggg cagagtcacc atgacagcgg acacgtctat agacacagcc
      361 tacatggaac tcagcagcct gacatctgag gacacggccg tgtattactg tgcggcagct
      421 gatagtggtt acccatttta ctacttcgat atctggggcc ctggcacccc aatcaccatc
      481 tcctccgcc
//
LOCUS       KCXD01007018             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:11407:12641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007018
VERSION     KCXD01007018.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:11407:12641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65500.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          134 c          132 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 gactccatca gtagtagcta ctggaactgg atccgccagc ccccggggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgagtc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007019             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:12644:16553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007019
VERSION     KCXD01007019.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:12644:16553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65501.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..503
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          105 a          124 c          160 g          116 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcaacttca attactacta
      241 catgaactgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgacag
      301 tggtggggat agcacatact atgcggactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaatt ggacagcctg agagctgagg acacggctgt
      421 ctattactgt gcgagagtgg tgggtggtgc cgcaggatac ttcgacttct ggggccaggg
      481 cgccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007020             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7025:6752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007020
VERSION     KCXD01007020.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7025:6752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..463
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65502.1"
                     /translation="CARVESAWSVGWDYW"
     D_segment       416..422
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           82 a          138 c          144 g          101 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagttgaa gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gtctccatca gcactcactc ctggagctgg gtccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tagtggtggg cgcacggact acaatccctc cctcaagagt
      301 cgagtcacct tttcaacaga cacgtccagg aaccggttgt ccctgaggct gaccgctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagttg aaagcgcctg gtccgtgggg
      421 tgggattact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007021             432 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17571:19944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007021
VERSION     KCXD01007021.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 432)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 432)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17571:19944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..430
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..430
     V_segment       76..374
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <364..>399
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65503.1"
                     /translation="CARVVAAGVDSW"
     D_segment       379..387
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       391..430
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        431..>432
                     /gene="IGHG"
BASE COUNT           87 a          139 c          109 g           97 t
ORIGIN      
        1 acatgggggt gccccaccat ggacacgctt tgctacacac tcctgctact gaccgtcccg
       61 tcctgggtct tgtcccaggt caccttgaag gagtctggtc ctgcgctcgt gagacccaca
      121 cagaccctca cgctgacctg caccttctct gggttctcaa tcgacactct cgcaacaggt
      181 gtgggctgga tccgtcagcc ccccgggaag gccctccaat ggcttgcaag catttattgg
      241 aatgatagta gattctacat cacatcgctg aagagccggc tcaccatctc caaggacacc
      301 tccaataacc aggtggttct gacaatgacc gacatggatc ctttggacac agccacatat
      361 tactgtgcac gcgttgtggc agctggtgtg gactcctggg gccagggagt cctggtcacc
      421 gtctcctcag cc
//
LOCUS       KCXD01007022             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9887:10173
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007022
VERSION     KCXD01007022.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9887:10173"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65504.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          138 c          130 g          108 t
ORIGIN      
        1 acatggggga tgctctctga gagtcttgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatctctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007023             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:18365:2046
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007023
VERSION     KCXD01007023.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:18365:2046"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..503
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65505.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       443..449
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..503
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          110 a          119 c          156 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcacaaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgaagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc agcttcaatt attactacat
      241 gagctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaatagtgg
      301 tggggaaagc acatactctg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acgctatatc ttgaaatgga cagcctgaga actgaggaca cggctgtcta
      421 ttattgtgtg agagatcgac gtgtacagtc gttatcctgg ttcgatgtct ggggcccggg
      481 agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007024             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15976:6699
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007024
VERSION     KCXD01007024.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15976:6699"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65506.1"
                     /translation="CARRGIAAGWSFDYW"
     D_segment       444..449
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          114 c          160 g          116 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagttgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gaaactctcc tgcgcagcgt ctggatttag tttcagttcc tactacatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtggat ttcaggtatt gacaatggtg
      301 gggggaacac atactatgca gactccgtga agggcagatt caccatctcc agagagaacg
      361 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacatg gctgtctatt
      421 actgtgcgag aagagggata gccgctggat ggagctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007025             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19706:20643
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007025
VERSION     KCXD01007025.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19706:20643"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65507.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          109 a          142 c          136 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcttt ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaattgag
      361 cagcctaaga tctgaggaca cggccgtgta ttactgtgcg attggaccta ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01007026             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:9938:14559
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007026
VERSION     KCXD01007026.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:9938:14559"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65508.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       408..416
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           95 a          132 c          135 g          115 t
ORIGIN      
        1 acatggggat gttctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcagag accctgtccc tcacctgcgc tgtctctgga
      181 ggctctctca gcggtggtta tgactggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg gctatatcta tggtgctaga gggagcacca cctacaaccc gtccctcagg
      301 aatcgagtca ccatttcaaa agacacgtcc aagaaccagt tgtccctgaa gttgagttct
      361 gtgaccgccg cggacacggc cgtatattat tgtgcgagac agtgctgtta ttatgatgac
      421 tttttagact actttgactt ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007027             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:12058:8144
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007027
VERSION     KCXD01007027.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:12058:8144"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65509.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          120 c          147 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcatctt cagtacctat
      241 gccatgcact gggtccgcca ggctccaggg aaggggctgg aatgggtgtc agttatttcg
      301 catgatggaa ctaagaaata ctacacagac tctgtgaagg accgattcac catctccaga
      361 gacaattccg agaacaaaca atatcttcac atgaatgacc tgaaattgga ggacacggcc
      421 atatactact gtgcggcctc ctacttgggg tacggatttg aatactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007028             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:20457:5350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007028
VERSION     KCXD01007028.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:20457:5350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65510.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       439..444
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          116 c          152 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagttcgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtccg gtgtgaggtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtaactat
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 tctgatggaa gtaagaaata ctacgcaaac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatact ctatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtctattact gtgcgagaga tgatatgggg accggttttg actactgggg ccagggagtc
      481 ctggtcatcg tctcctcagc c
//
LOCUS       KCXD01007029             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14602:8179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007029
VERSION     KCXD01007029.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14602:8179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65511.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       438..445
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          112 c          152 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtaac tctggcattc
      241 actgggtccg ccaggctcca ggggcggggc tggagtgggt ggaagttata tcgtatgatg
      301 aaagtaagac atactacgca gactctgtga aggaccgatt caccatttcc agagacaaat
      361 ccaagaacat ggtacatctt caaatgaaca ccctgaattt ggaggacacg gccgtatatt
      421 actgtgtgag agattcttac ggtagaggct ttgaccagtg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007030             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:6208:6979
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007030
VERSION     KCXD01007030.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:6208:6979"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65512.1"
                     /translation="CVRDAFGSGLDYW"
     D_segment       447..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          155 g          120 t
ORIGIN      
        1 acatggggga gcgctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gttattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gcttcacctt caattccttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc ggttatatcg
      301 catgatgaaa ctaagaaata ctacgcagac tctgtgaaag accgattcag catctccaga
      361 gacaattcca agaacatggt ctatcttcaa atgaacaacc tgagattgga ggacacggcc
      421 gtctattact gtgtgagaga tgcgtttggt agcgggcttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007031             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8882:4041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007031
VERSION     KCXD01007031.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8882:4041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65513.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       428..435
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          115 a          138 c          154 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga ccctggaaat ggtgaaataa
      301 tacacgcaga tagtttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcggc ctgagatctg aggacacggc cgtgtattac tgtgcgagag
      421 gggggttcgg tagcagtgtc tggtccaatc tcgtttatgg tttggattcc tggggccaag
      481 gggtcgccgt caccgtctcc tcagcc
//
LOCUS       KCXD01007032             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15880:18471
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007032
VERSION     KCXD01007032.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15880:18471"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65514.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       442..447
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          114 c          153 g          118 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctatggcatc
      241 cactgggtcc gccaggctcc ggggaagggg ctggagtggg tgacagttat atcgtatgat
      301 gaaacaaaga aattctacgc aggctctctg aaggaccgct tcatcatctc cagagacaac
      361 tccaagaaca tggtatatct tcaaatgaat agcctgcaat tggaggacac ggccatatat
      421 tactgtgtga gagatgtcag gggaacgggg tttgacttct ggggccaggg tgtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007033             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17577:2069
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007033
VERSION     KCXD01007033.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17577:2069"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65515.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       401..412
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..470
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          140 c          136 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctttggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc agtaactact ggagctgggt ccgccagtcc ccagggaagg gactggagtg
      241 gattggacgt atctctggta gtggtgggag caccgtctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccataaa ccagatctcc ctgagagtga cctctgtgac
      361 cgccgcggac acggccgtat attattgtgc gacagccgga tatagcagca gcgaaagctt
      421 ctacggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007034             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20196:20655
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007034
VERSION     KCXD01007034.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20196:20655"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65516.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          133 c          137 g           97 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggggg
      181 ctccatcagc agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggatgggg tgtatctatg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaagc tgaggtctat
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007035             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:6737:3321
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007035
VERSION     KCXD01007035.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:6737:3321"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    110..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        110..463
     V_segment       110..398
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65517.1"
                     /translation="CASGGIAATGPDSW"
     D_segment       402..420
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           79 a          141 c          141 g          104 t
ORIGIN      
        1 acatggggga aatgctctct gagagtcacg gacctcctgt gcaagaacat gaagcacctg
       61 tggttcttcc tcctcctggt ggtagctccc agatggatcc tgtcccaagt gcagctgcgg
      121 gagtcgggcc cgggactggt gaagccttcg gagaccctgt ccctcacctg cgctgtctct
      181 ggtgtctcca tcagcggtta ctggtggggc tggatccgcc agcccccagg gaagggactg
      241 gagtggattg ggtttttcgg tggtagtctt ggggacccct actaccactc ctccctcaag
      301 agtcgagtca ccatttcaac agacacgtcc aataaccggt tctccctgag gctgacctct
      361 gtgaccgccg cggacacggc cgtttattac tgtgcgagcg ggggtatagc agcgactggt
      421 ccggactcct ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007036             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:8106:6246
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007036
VERSION     KCXD01007036.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:8106:6246"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..494
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65518.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       414..427
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          110 a          136 c          147 g          107 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 acctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg atacaccttc agcatctctt ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttgg gtggatagga gggatcatcc ctcttgttgg tatgacaaac tacgaacagg
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac gaatacagtc ttcatggaac
      361 tgagcagcct gagatcggag gacacggccg tctactattg tgcgacaggg gtatattacc
      421 aggatgaaaa cggttatttt tatgtcggcg gggactttga ctactggggc cagggagtcc
      481 tggtcaccgt ctccccagcc
//
LOCUS       KCXD01007037             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15849:19245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007037
VERSION     KCXD01007037.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15849:19245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65519.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       445..451
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          112 c          154 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca cctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcctctgga ttcaccttca gtagttatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aagaaatact acacagacgc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gaacaacctg aagttggagg acacggccgt
      421 gtattactgt gggagagatg ataatggggt gcttatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007038             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11219:18164
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007038
VERSION     KCXD01007038.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11219:18164"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..490
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65520.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       433..439
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          116 a          111 c          144 g          121 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcaacaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc ggtgtgaggt gcaactggtg gagtctggag gaggcttggt tcaacctggg
      181 gggtccctga gactctcctg tgaagcctct ggattcacct tcagtaagtt tggcatacac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatttc gtctgatgga
      301 agtaacaaat actacgcaaa ctctgtgaag agccgattca ccatctccag agacaattcc
      361 aagaacatac tttatcttca aatgaacaac ttgaaattgg aggacacggc cgtctattac
      421 tgtgcgagag atgatattgg gaccggtttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01007039             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:22017:14810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007039
VERSION     KCXD01007039.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:22017:14810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65521.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          118 c          149 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctgttgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagtctctgg attcaccttc aatacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 gtgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tttattactg tacgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007040             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:22982:12965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007040
VERSION     KCXD01007040.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:22982:12965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..488
     V_segment       136..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65522.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       432..440
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>492
                     /gene="IGHG"
BASE COUNT          113 a          110 c          155 g          114 t
ORIGIN      
        1 acatggggga gaggagccca gccctggaag tccacagtgt tccattcggt gatcagcaca
       61 gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc ggtgtgaggt gcagctggtg gagtctggag gaggcttggt tcagcctggg
      181 gggtccctga gactctcctg tgcagcctct ggattcacct tcagttacta tggcatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtgg cagttatgtc gaatgatgga
      301 agtaagaaat actacggaga ctctgtgaag gaccgattca ccatctccag agacaattcc
      361 aagaacaggc tatatcttca aatgaacaac ctgaaattgg aggacacggc agtgtattac
      421 tgtgcgagag atgatagtgg ggtgatcatc gactactggg gccagggagt cctggtcacc
      481 gtctcctccg cc
//
LOCUS       KCXD01007041             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:16620:17943
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007041
VERSION     KCXD01007041.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:16620:17943"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..498
     V_segment       141..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65523.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       439..444
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          113 c          151 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagaccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt cacgttcagt aactatggaa
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtacg
      301 atgaagataa gaaatactac gcagactctc tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctttat cttcaaatga acaacctgaa attggaggac acggccgttt
      421 attactgtgc gaggaggccc tggagtgcag atgcttttga tttctggggc caaggactca
      481 gggtcaccgt ctcttcagcc
//
LOCUS       KCXD01007042             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:27369:6352
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007042
VERSION     KCXD01007042.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:27369:6352"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65524.1"
                     /translation="CAVGPSGTWNHWSFDIW"
     D_segment       406..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          105 a          147 c          131 g           92 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gatgcagccc ggggcctcag tgaaggtctc
      181 ctgcaaggtc tccggaaaca ccttcaccga attgtccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgatcccgca tatggtgaaa tgacgttcca
      301 gggcagagtc atcatgaccg aggacacgtc tacagacaca gcctacatgg aactgaccag
      361 cctgacatct gacgacacgg ccgtctatta ctgtgcggtt ggccctagtg gcacttggaa
      421 ccactggtcc ttcgatatct ggggccctgg caccccagtc accatctcct cagcc
//
LOCUS       KCXD01007043             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:14356:12867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007043
VERSION     KCXD01007043.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:14356:12867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65525.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          112 c          154 g          121 t
ORIGIN      
        1 acatggggtc tctgggagag gagcccagcc ctggaagtcc acagtgttcc atttggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtcgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcgtctgga ttcaccttca gtaactttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgca
      301 tgatgaaaat aacaaatact acgcagactc tgtgaaggac cgattcaccc tttccagaga
      361 caactccaag aaaatgctat atcttcaaat gaacgacctg aaattggggg acacggccgt
      421 gtattattgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007044             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20344:11510
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007044
VERSION     KCXD01007044.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20344:11510"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    50..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        50..428
     V_segment       50..341
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <335..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65526.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       360..370
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       383..428
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT           97 a          115 c          128 g           90 t
ORIGIN      
        1 acatgggagg atcctcctct tggtggcagc agctacaggc gcccactctg aggtccacct
       61 ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct cctgcaaggt
      121 ttccggatac accgtcaccg aattatccat gcactgggtg cgacaggccc ctggacaagg
      181 gcttgagtgg atgggacttg ttgatcctgt aaatggtgaa ctaatacacg cagacaagtt
      241 ccagggcaga gtcaccatga ccgaagacac gtctacagac acagcctaca tggagttgag
      301 cagcctgaca tctgaggaca cggccatcta ctactgtgcg acaggaagga tcggtaccag
      361 tggctggtcc aacctcttca atggtttgga ttcctggggc caaggggtcg tcgtcaccgt
      421 ctcttcagcc
//
LOCUS       KCXD01007045             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8184:11073
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007045
VERSION     KCXD01007045.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8184:11073"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65527.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       445..452
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          115 a          121 c          146 g          130 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga ctcaccatgg agtttatgct gagctgggtt ttccttgttt
      121 ctatattaaa aggtgtccag tgtgtggagc atctggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg cagcctctga attcaccttt agtggctatg
      241 acatgcactg ggttcgccag gctccaggga agggtctaga atgggtatca ggtattaaca
      301 ttggcggtga cccatactac ccagactctg tgaagggtcg attcaccatc tccagagaca
      361 acgccaagaa ctccttgtat cttcaaatga acaacctgag acctgaggac actgctgtgt
      421 attattgtgt gagggggatg gataactacc acttcagtaa tacggacttt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007046             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19131:3466
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007046
VERSION     KCXD01007046.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19131:3466"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..327
     V_segment       1..269
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65528.1"
                     /translation="CARWSAANFDLW"
     D_segment       274..280
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           66 a           97 c           93 g           73 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggg ggctccatca
       61 acagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg gagtggattg
      121 ggtgtatcta tgatagtagt ggaaacacct actacaaccc ctccctcaag agtcgagtca
      181 ccatttcaaa agacacgtcc aagaaccagt tctccctgaa tctgaggtct atgaccgccg
      241 cggacacggc cgtgtttttc tgtgcgagat ggtcggcagc caactttgac ctctggggcc
      301 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007047             274 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19518:14020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007047
VERSION     KCXD01007047.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 274)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 274)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19518:14020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..272
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..272
     V_segment       8..187
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <179..>241
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65529.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       191..210
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       223..272
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        273..>274
                     /gene="IGHG"
BASE COUNT           59 a           75 c           82 g           58 t
ORIGIN      
        1 acatgggcag gcccctggac aagggcttga gtggatggga ggcatcttcc ctcttgttgg
       61 tacaacaaac tacgcacaga agttccaggg cagagtcacg attaccgcgg acacgtccac
      121 aagcacagcc tacatggacc tgagcagcct gggatctggg gacacggccg tgtattattg
      181 tgcgagaggt tactgtactg gtagtggttg taaccttaca ttcaaccggc tcgatgtctg
      241 gggcccggga gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01007048             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20829:10555
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007048
VERSION     KCXD01007048.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20829:10555"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65530.1"
                     /translation="CARDAYGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          119 c          149 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcccagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaagtgca actggtggag tctggaggag gcttggttcg
      181 gcctgggggg tccctgagac tctcctgttc agcctctgga ttcaccttca gtaattttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact atgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aatatgctat atcttcaaat gaacaacctg aagttggagg acacggccgt
      421 ctattactgt gcgagagacg catatggcag cggctgtgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007049             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:23895:18350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007049
VERSION     KCXD01007049.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:23895:18350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65531.1"
                     /translation="CTRGRGVIIVFFDYW"
     D_segment       440..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          105 a          122 c          154 g          121 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc agttttggta aatatgacat
      241 gcattgggtc cgccaggctc cgggaaaggg cctggagtgg gtctcatcca ttagtaacac
      301 tggtgaaacc gtaaaatacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcgctgtctc tgcaaatgag cagcctgaga gccgaggaca cggccgtcta
      421 ttactgtact agaggtcgag gggtgattat cgtcttcttt gactactggg gccggggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007050             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:18217:20686
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007050
VERSION     KCXD01007050.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:18217:20686"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..494
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65532.1"
                     /translation="CVRDAYGTGLDSW"
     D_segment       443..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..494
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>500
                     /gene="IGHG"
BASE COUNT          109 a          118 c          151 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cgttcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag atgtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaattttg
      241 gcatgcactg ggtccgccag actccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatagaaa taatatatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattcgaa gaacatgctg tatcttcaaa tgaacaacct acagttggag gacacggccg
      421 tgtattcctg tgtgcgagat gcctacggta ccgggttgga ttcctggggc caaggcgtcg
      481 tcgtcatcgt ctccccagcc
//
LOCUS       KCXD01007051             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16735:10969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007051
VERSION     KCXD01007051.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16735:10969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65533.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          119 a          144 c          134 g           95 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatccactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 ctctcctcag cc
//
LOCUS       KCXD01007052             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11830:14393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007052
VERSION     KCXD01007052.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11830:14393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65534.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          105 a          125 c          159 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagatact
      241 ggatgaactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattacta
      301 gtggtgggga tagcacgtac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc tccctgcaaa tgaacagact tagagcggag gacacggccg
      421 tatattactg tgcgaacgcg ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007053             430 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:28109:16244
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007053
VERSION     KCXD01007053.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 430)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 430)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:28109:16244"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..428
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..428
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>397
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65535.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       380..386
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       387..428
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        429..>430
                     /gene="IGHG"
BASE COUNT          100 a           93 c          129 g          108 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctgttttaag
       61 aggtgtccag tgtgaggtac aattagtgga gtctggagga gacttggttc agccgggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg gcatacactg
      181 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt ctgatggaag
      241 taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag acaattccaa
      301 gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg tctattattg
      361 tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc tggtcaccgt
      421 ctcctcagcc
//
LOCUS       KCXD01007054             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:16505:17656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007054
VERSION     KCXD01007054.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:16505:17656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..475
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65536.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       392..413
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           99 a          132 c          137 g          109 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgc gagaacatga agtatctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccagctgc agttgcagga gtcgggccca
      121 ggactgatga agccttcaga gaccctgtcc ctcagctgcg ctgtctctgg tggctccata
      181 agtggtaact ggtggagctg gatccgccag cccccaggga agggactgga ctggattgga
      241 cgtatctctg gtactagtgg ggacaccaat tacaatccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccacttc tccctgaagc tgaactctgt gaccgccgcg
      361 gacgcggccg tgtattattg tgcaagagcg gattacgagg atgattacgg ttatcattta
      421 ggatacaact ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007055             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22194:15217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007055
VERSION     KCXD01007055.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22194:15217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..505
     V_segment       133..426
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <418..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65537.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       443..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          106 a          120 c          154 g          127 t
ORIGIN      
        1 acatggggag acaggagtct tagccctgga ttccaagaac ttccactttg ggatcagctc
       61 tgaacacaga ggaccatgga gttggggctg agctgggttt tccttgttgc tattttaaaa
      121 ggtgtccagt gtgaggtgga gctggtggag tctgggggag gcttggtcca gcctgggggg
      181 tccctgagac tctcctgtgt agcctctgga ttcacctttg gtgattatgg catgcactgg
      241 gtccgccagg ctccgggaaa gggactggag tgggtctcat ccattagaaa cactggtaaa
      301 atcgtatact acgctgactc cgtgaagggc cgattcatca tctccagaga caacgccaag
      361 aattcgctgt ttctgcaaat gagcagcctg agagtcgagg actcggccgt ctattactgt
      421 actagaattg gcgtcggatc tctagcaccg gctggtgaat actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007056             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:12598:14936
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007056
VERSION     KCXD01007056.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:12598:14936"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65538.1"
                     /translation="CARRPWSADALDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          117 a          115 c          152 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtaactatg
      241 gaatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaga taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgctct tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01007057             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:11573:8906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007057
VERSION     KCXD01007057.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:11573:8906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65539.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           94 a          137 c          130 g          106 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cagtagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattgggta catctctggt gcttatggga gcaccagcta caacccctcc ctcaagagtc
      301 gaatcaccat ttcaacagac acgtccaaga accagttttc cctggggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattactgtg tgagatatga ggatgaatcc attaattacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007058             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20033:12568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007058
VERSION     KCXD01007058.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20033:12568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65540.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           97 a          132 c          136 g          110 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagt ggttactatt ggagctggat ccgccagccc ccagggaagg gactggaatg
      241 gattgggtat attagtgcca gtactgggag caccgactac aacccctcct ttaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaggctga cgtctgtgac
      361 cgtcgcggac acggccgtgt attattgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggtccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007059             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15788:16750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007059
VERSION     KCXD01007059.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15788:16750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65541.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       447..453
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          117 a          113 c          149 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgctg
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggagac ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactatggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtctg
      301 atgcaagtaa gacatactac gcaaactctg tgaaggaccg attcaccata ttaagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attggaggac acggccgtct
      421 attactgtgc gagagacgat atgggaagtg gctttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007060             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17006:13837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007060
VERSION     KCXD01007060.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17006:13837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65542.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          114 c          154 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca gctggtggag tctggaggag gcttggttca
      181 gcctcggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgtc
      301 tgatggaagt agcatatact atgcagcctc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaatttgagg acacggccgt
      421 gtattactgt gcgagagatg tgtacggtag tgggttagac tactggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007061             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20506:6333
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007061
VERSION     KCXD01007061.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20506:6333"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65543.1"
                     /translation="CATGHSGRWINWYFEIW"
     D_segment       421..430
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          124 a          137 c          136 g           94 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacagcttca ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tgcatatggt gaaatgataa
      301 atacagagaa gttccagggc agagtcacca tgaccgagga cacgtccaca gacacagcct
      361 acatggagct gggcagtctg agctctgagg acacggccct gtattactgt gcaacaggcc
      421 atagcggcag gtggattaac tggtatttcg aaatatgggg ccctggtacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01007062             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18815:7003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007062
VERSION     KCXD01007062.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18815:7003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65544.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       437..444
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..495
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          119 a          112 c          149 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agaccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccaatgtgag gtgcagctgg tggagtctgg aggagacttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac gttcagtaac tatgggatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactacgca gactctctga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctttatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgcgag gaggccctgg aatgcagatg cttttgattt ctggggccaa ggactcaggg
      481 tcaccgtctc ttcagcc
//
LOCUS       KCXD01007063             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:27084:19870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007063
VERSION     KCXD01007063.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:27084:19870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..487
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65545.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       417..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>491
                     /gene="IGHG"
BASE COUNT          118 a          142 c          132 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggctacagct tcgccgaatt atccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggttttgc tagtatatat ggtcaaataa
      301 tacatacaga gagattccag ggcagagtca ccatgacagc ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgacatctg aggacacggc cgtgtattac tgtgcggcag
      421 ctgatagtgg ttacccattt tactacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctccgc c
//
LOCUS       KCXD01007064             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:13103:14254
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007064
VERSION     KCXD01007064.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:13103:14254"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65546.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          114 a          111 c          157 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aataggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 gtattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01007065             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:13588:9169
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007065
VERSION     KCXD01007065.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:13588:9169"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65547.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          113 c          149 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcaaccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcttgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaaataacaa atactacgca gactctgtga aggaccgatt caccatttct agagacaatt
      361 ccatgaacat gctatttctt caaatgaaca acctgaactt ggacgacacg gccgtctatt
      421 actgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007066             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17186:6626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007066
VERSION     KCXD01007066.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17186:6626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65548.1"
                     /translation="CVRDSYGSGLDSW"
     D_segment       438..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          109 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt aacggcatgc
      241 actgggtccg ccaggttcca gggaaggggc tggagtgggt ggcagtgaca tcgtttgatg
      301 aaagtaagaa atactacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agactcttat ggaagtggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007067             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8818:10753
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007067
VERSION     KCXD01007067.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8818:10753"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65549.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       422..430
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          110 a          142 c          136 g           93 t
ORIGIN      
        1 acatgggggg catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cttctggtgc agtctggggc tgaggtgatg cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaacacctt caccgaattg tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgac
      301 gttccagggt agagtcacca tgaccgagga cacgtctaca gacacagcct acatggaact
      361 gagcagcctg acatctgagg acacggccgt gtattactgc gcgattggcc ctagtggcag
      421 atggaacgac tggtccttcg acatctgggg acctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01007068             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:18309:6766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007068
VERSION     KCXD01007068.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:18309:6766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65550.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          118 c          149 g          122 t
ORIGIN      
        1 acatggggag ctcttggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cgattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccggaggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtttctatg
      241 gcttccactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatctcga
      301 acgatgaaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atttctagag
      361 acaattccat gaacatgcta tttcttcaaa tgaacaacct gaacttggac gacacggccg
      421 tctattactg tgtgagagat gatttaggca gcggcttagg gtcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007069             342 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:17843:5971
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007069
VERSION     KCXD01007069.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 342)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 342)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:17843:5971"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..340
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..340
     V_segment       7..257
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>309
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65551.1"
                     /translation="CSSDYYSGSYYYWGYGLDSW"
     D_segment       260..284
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       291..340
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        341..>342
                     /gene="IGHG"
BASE COUNT           71 a           91 c          100 g           80 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt gcagcctctg gattcagctt tggcgatcat
       61 ggcatgcact gggtccgcca ggctccggga aagggactgg agtgggtctc atctatcagt
      121 aatactggta aagccgtaca ctacgctgac tccgtgaagg gccgattcac catctccaga
      181 gacaacgcca agaactcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      241 gtgtattact gttctagcga ttactatagt ggtagttatt actattgggg ctacggcttg
      301 gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007070             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24389:14744
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007070
VERSION     KCXD01007070.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24389:14744"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..392
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65552.1"
                     /translation="CAIQGLVVVAGFDYW"
     D_segment       407..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           86 a          138 c          135 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtacagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc gcttactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtat atctatggtg gtagtgggag caccacctac aacccgtccc tcaagagtcg
      301 agtcaccttt tcaatagaca cgtccaagaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtct attactgtgc gatccaaggg ctcgttgtgg ttgcgggctt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007071             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18326:7022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007071
VERSION     KCXD01007071.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18326:7022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65553.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          143 c          144 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007072             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17565:16959
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007072
VERSION     KCXD01007072.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17565:16959"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65554.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       416..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          145 c          137 g           93 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcat agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gcaacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggcgt tgatcctgcg tatggtgaat ttacacccgg
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctatagaca cagcctacat
      361 ggagctgtac agcctgaact ctgaggacac ggccgtctat tactgtgcag ccggctatag
      421 cggcagctgg aaccactggt acttcgatct ctggggccct ggcaccccaa tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01007073             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:13218:16353
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007073
VERSION     KCXD01007073.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:13218:16353"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65555.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       443..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          116 c          149 g          120 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgcgatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagccg
      181 gaggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagttt ctatggcttc
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttat ctcgaacgat
      301 gaaaataaca aatactacgc agactctgtg aaggaccgat tcaccatttc tagagacaat
      361 tccatgaaca tgctatttct tcaaatgaac aacctgaact tggacgacac ggccgtctat
      421 tactgtgtga gagatgattt aggcagcggc ttagggtcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007074             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8362:14552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007074
VERSION     KCXD01007074.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8362:14552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65556.1"
                     /translation="CARMWYWPTPDVW"
     D_segment       403..409
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..458
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           84 a          132 c          141 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaggc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 ctccatcagc ggtggttatg gctggaactg gatccgccag gccccaggga agggactgga
      241 gtggattggg agtctctttg gcagtagtgg aagaacctac tacaatccgt ccctcaagag
      301 tcgagtcgct atttcaaaag acacgtccaa gaaccagttc tccctgatcc tgaggtctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaatg tggtactggc cgacccccga
      421 tgtctggggc ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007075             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:15764:17493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007075
VERSION     KCXD01007075.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:15764:17493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65557.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          141 c          126 g          100 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatcc ctgcactggg ttcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag ttttaatcct atatatggtg aaattttaca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagtc
//
LOCUS       KCXD01007076             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:24054:10307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007076
VERSION     KCXD01007076.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:24054:10307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65558.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       445..451
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          119 c          151 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtcca cctggtggaa tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaatact acgccgactc tttgaaagac cgattcacca tatccagaga
      361 cgactccagg aacatgctat atcttcaact gaacaacctg aaattggacg acacggccgt
      421 gtattactgt gcgagagatg tgtatggctg ggggcttgac tactggggcc agggagtcct
      481 agtcaccgtc tcctcagcc
//
LOCUS       KCXD01007077             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10480:7911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007077
VERSION     KCXD01007077.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10480:7911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65559.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          109 a          119 c          161 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgtgg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctaga gtgggtctca actattaata
      301 gtggtgggga taacacatat tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattactg tgttcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01007078             353 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8739:18305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007078
VERSION     KCXD01007078.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 353)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 353)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8739:18305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..351
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..351
     V_segment       8..280
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <273..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65560.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       293..301
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       310..351
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        352..>353
                     /gene="IGHG"
BASE COUNT           74 a          100 c          104 g           75 t
ORIGIN      
        1 acatgggggg cccaggactg gtgaagcctc cggagaccct gtccctcacc tgcgctgtct
       61 ctggtggctc tatcagcagt agttactgca gctggatccg ccagacccca gggaagggac
      121 tggagtggat tggctatata tatgggagtg atagtagcac caactacaac ccctccctca
      181 agagtcgagt caccctgtca gtagacacgt ccaagaacca gtgctccctg aaggtgagct
      241 ctgtgaccgc cgcggacacg gccgtgtatt attgtgcgag ttcgggtata gaagtggttg
      301 cctacagcat tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007079             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:10037:8386
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007079
VERSION     KCXD01007079.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:10037:8386"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..493
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65561.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       418..426
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          112 a          140 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agttggtgca gtctggggct gaagtgagga agcctggggt ctcagtaaag
      181 gtctcctgca aggtttccgg aaacaccatc accgaattat ccgtgcactg ggtgcgacag
      241 gcccctggaa aaggccttga gtggatgggg ggtgttgatc ccgtctatgg tgaaataaga
      301 cacgcagaga acttccaggg cagagtcacc atgaccgagg acacgtcgac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctattactg tgcgcgagga
      421 tattgtcatg gtagttactg ttcctcgggt cttgtctcct ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007080             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:22851:9201
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007080
VERSION     KCXD01007080.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:22851:9201"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65562.1"
                     /translation="CARARAVIITYFDSW"
     D_segment       447..452
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          116 c          156 g          123 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gtaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttat ttctacatga
      241 gctgggtccg tcaggctcca gggaaggggc tggagtggat ctcaagtatt gacagtggtg
      301 ggactaccgc aaattatgca gactccgtga ggggcagatt catcatctcc agagagaacg
      361 ccaagaatat agtgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 attgtgcgag agcgcgcgcg gtgatcatta catactttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007081             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11218:6378
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007081
VERSION     KCXD01007081.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11218:6378"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..482
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65563.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       406..431
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           97 a          138 c          133 g          116 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agttgcacga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tgtctccatc aacattaact actggagctg gatccgccag tccccaggga aggggctgga
      241 gtggattggg tttatctatg gtggtgatgg ctacaccacc tccaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaagc tgaagtctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgcgagatat ccgcgttacg aggatgatca
      421 cggttactat tctgtggaaa ttgactactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01007082             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22818:14606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007082
VERSION     KCXD01007082.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22818:14606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65564.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       448..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          111 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctttg
      241 gcatgcattg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcga
      301 atgatggaag taagaaatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaaaatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg cgcgagagac gattttggca gcggcttagg gtactgggac cagggagccc
      481 tggtgaccgt ctcctcagcc
//
LOCUS       KCXD01007083             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21235:3828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007083
VERSION     KCXD01007083.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21235:3828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65565.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          111 a          112 c          156 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccggg
      181 ggggtccctg agagtctcct gtgcagcctc tggattcacc ttcagtacta gcggcatgca
      241 ctgggtccgc caggctccag ggaagggact ggagtgggtg gctgttgaat cgcatgatgg
      301 aaataagaaa tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggatacgg ccgtgtatta
      421 ctgtgtgaga gatgcctacg ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007084             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15292:11172
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007084
VERSION     KCXD01007084.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15292:11172"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65566.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          110 c          155 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcat gttcagtaac tttggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtcagttata tcgtatgatg
      301 taactgtgaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacac gctatatctt caaatgcaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgtgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01007085             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15200:8168
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007085
VERSION     KCXD01007085.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15200:8168"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65567.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          122 c          148 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgccattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtcccg gagactctcc tgtgcagcct ccggattcac cttcagtacc tatgccatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgcatgatg
      301 gaactaagaa attctacaca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat acaatatctt cacatgaaca acctgaaatt ggaggacacg gccatatact
      421 actgtgcggc ctcctacttg gggtacggat ttgagtactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007086             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:11008:7945
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007086
VERSION     KCXD01007086.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:11008:7945"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65568.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       439..443
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          117 c          156 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca tctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttcctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggac tgggtggcag ttatgtcgtc
      301 tgatggaagt aacaagtact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatggttt atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgagagatg tctttggcgg ggggcttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007087             323 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:13163:12748
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007087
VERSION     KCXD01007087.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 323)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 323)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:13163:12748"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..321
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..321
     V_segment       9..260
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>290
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65569.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       270..275
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..321
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        322..>323
                     /gene="IGHG"
BASE COUNT           79 a           77 c           91 g           76 t
ORIGIN      
        1 acatgggggg ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtacct
       61 atggcatcca ctgggtccgc caggctccag ggaaggggct ggagtgggtg acagttatat
      121 cgtatgatga aacaaagaaa tactacgcag actctctgaa ggaccgcttc atcatctcca
      181 gagacaattc caagaacatg gtatatcttc aaatgaataa cctgaaattg gatgacacgg
      241 ccgtatatta ctgtgtgaga gatgtcaggg gaacggggtt tgacttctgg ggccagggtg
      301 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007088             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12420:7440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007088
VERSION     KCXD01007088.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12420:7440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..280
     V_segment       8..219
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <211..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65570.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       230..238
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       246..280
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>282
                     /gene="IGHG"
BASE COUNT           69 a           67 c           76 g           70 t
ORIGIN      
        1 acatgggcct tcagtttcta tggcttccac tgggtccgcc aggctccagg gaaggggctg
       61 gagtgggtgg cagttatttc gaatgatgaa aataacaaat actacgcaga ctctgtgaag
      121 gaccgattca ccatttctag agacaattcc atgaacatgc tatttcttca aatgaacaac
      181 ctgaacttgg acgacacggc cgtctattac tgtgtgagag atgatttagg cagcggctta
      241 gggtcctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007089             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15650:16657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007089
VERSION     KCXD01007089.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15650:16657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65571.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          114 a          144 c          129 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttccgg atacacctta accgaccact acctacactg ggtgcgacag
      241 gctcctggaa aaggacttga gtggatggga ggtattcttc ctgagtatgg taaagttgac
      301 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga ctactggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007090             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:20058:6630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007090
VERSION     KCXD01007090.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:20058:6630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..507
     V_segment       126..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65572.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       428..451
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          115 a          142 c          146 g          106 t
ORIGIN      
        1 acatgggggc atcacataac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc
       61 tcatcaccat ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc
      121 agtcccaggt ccagttggtg cagtccgggg ctgaggtgaa gaggcctggg gcctcagtga
      181 agctctcctg caaggctcct ggatacatct tcagcatatc tgccatcagt tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagggatcat ccctcttgtt ggtgtaacaa
      301 cctacgcaca gaagttccag gacagagtca cgattaccgc ggacacgtcc acaagcacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgagtg
      421 gcggcttcga ggatgataac ggtcactatt atacgacact aacatttcac gattggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007091             372 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6727:16729
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007091
VERSION     KCXD01007091.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 372)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 372)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6727:16729"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..370
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..370
     V_segment       8..291
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <283..>339
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65573.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       306..313
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       331..370
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        371..>372
                     /gene="IGHG"
BASE COUNT           68 a          107 c          115 g           82 t
ORIGIN      
        1 acatgggagg agtcgggccc agcagtggtg aagccttcgg agaccctgtc cctcacctgc
       61 gctgtctctg gtggctccat cagcggtggt tatggctgga gctggatccg ccaggcccca
      121 gggaagggac tggagtggat tggttttatc tatggtactg gtggtagcac ctactacaca
      181 ccctccctca agaggcgact caccatttca gcggacacgt ccaagaacca gttctccctg
      241 catctgacct ctgtaaccgc cgcggacacg gccgtgtatt actgtgcgag agtttcgggc
      301 aggtgggaac tatttgagcc tgggtcagag gacttctggg gccagggagt cctggtcacc
      361 gtctcctcag cc
//
LOCUS       KCXD01007092             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:20124:7481
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007092
VERSION     KCXD01007092.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:20124:7481"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..486
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65574.1"
                     /translation="CATSSSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>490
                     /gene="IGHG"
BASE COUNT          120 a          142 c          132 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgaat ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggaactg agcagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc
      421 cagcggcacc tggctatact ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctccgcc
//
LOCUS       KCXD01007093             525 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7764:12656
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007093
VERSION     KCXD01007093.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7764:12656"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..523
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..523
     V_segment       142..434
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>492
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65575.1"
                     /translation="CSRAAYEHDDGYYYVGRFFDCW"
     D_segment       449..468
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       481..523
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        524..>525
                     /gene="IGHG"
BASE COUNT          112 a          130 c          155 g          128 t
ORIGIN      
        1 acatggggtc tgagagagga gccttagccc tggatttcaa ggcacttcca cctggggatc
       61 agcactgaac acagaggacc caccatggag ttggggctga gctgggtttt ccttgttgct
      121 attttaaaag gtgtccagtg tgaggtgcaa ctggtggagt ctgggggagg cttggtccag
      181 cctggagggt ccctgagact ctcctgtgca gcctctggat tcaccttcag tagttacgac
      241 atgacctggg tccgccaggc tccgggaaag gggctggagt gggtctcata tattagttac
      301 actggtaaaa ccatatacta ctctgactcc gtgaagggcc gattcaccat ctccagagac
      361 aacgtcaaga actctctgtc tctgcaaatg agcagcctga gagccgagga cacggccgtg
      421 tattattgtt ctagagcggc ttacgaacat gatgacggtt actattacgt cggcaggttt
      481 tttgactgct ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007094             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15952:13190
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007094
VERSION     KCXD01007094.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15952:13190"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    85..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        85..438
     V_segment       85..378
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65576.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       385..391
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..438
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>444
                     /gene="IGHG"
BASE COUNT          101 a          100 c          132 g          111 t
ORIGIN      
        1 acatggggag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
       61 gctattttaa gaggtgtcca gtgtgaggta caattggtgg agtctggagg aggtttggtt
      121 cagcctgggg ggtccctgag actctcctgt gcagcttctg gattcacctt cagtaactat
      181 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      241 tatgatgtaa gtaagaaata ctacgcagac tctgtgcagg accgattcac catctccaga
      301 gacaattcta agaacatgct acatcttcaa atgagcaacc tgaaattgga ggacacggcc
      361 gtgtatttct gtgcgagacg cccttggaac gctgactact ttgactactg gggccaggga
      421 gtcctggtca ccgtctccgc agcc
//
LOCUS       KCXD01007095             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22754:6588
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007095
VERSION     KCXD01007095.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22754:6588"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65577.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       442..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          116 a          111 c          151 g          118 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgacc tgggttttcc ttgttgctat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggagcct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ttctggattc accttcagta gttatggcat
      241 gcactgggtc cgcctggctc cagggaaggg gctggagtgg gtggcagtta catcgtctga
      301 tgaaagtaag aaatactacg gagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atactatatc ttcaaatgaa caacctgaaa ttgaaggaca cggccgtgta
      421 ctactgtggg agagatgata atggggtgat tatcgactac tggggccagg gagtcctggt
      481 caccgtgtcc tcagcc
//
LOCUS       KCXD01007096             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:22444:10671
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007096
VERSION     KCXD01007096.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:22444:10671"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65578.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       404..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           88 a          139 c          136 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggctat atcagtggga gtagtgggag taccgactac aagtcctccc tcaacagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagctctcc ctgagactga actctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagtccgg ggcgttacta tccactactt
      421 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007097             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16909:13263
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007097
VERSION     KCXD01007097.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16909:13263"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65579.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       446..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          110 c          158 g          118 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcagcttcag tatctttggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatgtcgaat
      301 gatggaagta agaaatacta cacagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga aaatgctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattattgcg cgagagacga ttttggcagc ggcttagggt actggggcca gggagccctg
      481 gtgaccgtct cttcagcc
//
LOCUS       KCXD01007098             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23420:10597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007098
VERSION     KCXD01007098.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23420:10597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..486
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65580.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       407..429
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT           99 a          142 c          131 g          116 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacatgcgct gtctctggtg
      181 gctctatcag cagtactaaa tggtggaact ggatccgcca gcccccaggg aaagggctcg
      241 agtggattgg gtatatcagt ggtagtagtg gtaacaccta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaca gacacgtcca acaaccagtt ctccctgaag ctgagctctg
      361 tgaccgccgc ggacacggcc ttttattatt gtgcgagatc ccaatcatat tgtagtgggc
      421 tttactgctt cggctactac tactttgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01007099             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:2928:8986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007099
VERSION     KCXD01007099.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:2928:8986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65581.1"
                     /translation="CAREDYGGNYYFNRFDVW"
     D_segment       399..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..470
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          137 c          139 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc ctctggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatgagc agtcactact gcagctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattggatgg atctctggta gtggtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccctc tcaacagaca cgtccaagaa ggagatctcc ctgaagctga gctctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagaagac tatggtggta attattactt
      421 taaccggttc gatgtctggg gcccgggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007100             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:11026:16713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007100
VERSION     KCXD01007100.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:11026:16713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65582.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       407..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           93 a          131 c          140 g          103 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag cctccggaga ccctgtctct cacctgcggt gtctctggtg
      181 gctctatcag cagtagttac tgcagctgga tccgccagac cccagggaag ggactggagt
      241 ggattgggta tatctatggg agggatagta gtaccaagta caacccctcc ctcaagagtc
      301 gagtcaccct gtcagtagac acgtccaaga accagtgctc cctgaagctg agctctgtga
      361 ccgccgcgga cacggccgtg tattattgtg cgagttcggg tatagaagtg gttgcctaca
      421 gcattgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007101             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:24210:8626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007101
VERSION     KCXD01007101.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:24210:8626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65583.1"
                     /translation="CARVSGHTEGTVEYFDSW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          118 a          120 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca cttatatcgt
      301 ttgatggaac taagcaatac tacgcagact ctgtgaagga ccgattcacc atttccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattgggg gacacggccg
      421 tacattactg tgcgagagtt agtgggcata cagagggtac agttgaatac tttgactcct
      481 ggggccaggg aaccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007102             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:8520:6286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007102
VERSION     KCXD01007102.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:8520:6286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65584.1"
                     /translation="CARDRFMGIGALGYW"
     D_segment       400..404
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           89 a          132 c          144 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgta agagcatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag cagtggtgaa gccttcggag accctgtccc tcacctgcga agtctctggt
      181 ggctccatca gcggtggtta tggctggacc tggatccgcc aggccccagg gaagggactg
      241 gagtgggttg ggagaatgta tggtagcagt ggtagcacct actacaaccc ctccctcaag
      301 ggtcgagtca ccatttcaaa agacacgtcc aagatccagt tctccctgaa gctgacctct
      361 gtgaccgccg cggacacggc cgtttattat tgtgcgagag ataggttcat gggcataggg
      421 gctctcggct actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007103             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15069:7450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007103
VERSION     KCXD01007103.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15069:7450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65585.1"
                     /translation="CVRDVRGGGFDYW"
     D_segment       448..456
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          115 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cacacggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgggg ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcgttcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaaa taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaccatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtatttctg tgtgagagat gtcagaggcg gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007104             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:22540:9421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007104
VERSION     KCXD01007104.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:22540:9421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..416
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <408..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65586.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       417..422
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          116 a          142 c          129 g           92 t
ORIGIN      
        1 acatggggga tcacacaacc accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggctcctcc tcttggtggc agcagctaca ggcgcccact
      121 ccgaggtcca gctggtacag tctggggctg aggtgaagaa gcctggggcc tccgtgaaaa
      181 tctcctgcca ggcttccgga tacaccttaa ccgaccacta cctacactgg gtgcgacaga
      241 ctcctggaaa aggacttgag tggatgggag gtgttcatcc tgaatatggt aaagtagact
      301 acacacagaa gttccaagac agagtcacca tcaccgcgga catgtcgaca gagacagtct
      361 acatggagct gaggagcctg agatctgagg acacggccgt ttattactgt gtgacagtgg
      421 gtccctacca ttactttgac ttctggggcc agggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007105             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15390:14483
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007105
VERSION     KCXD01007105.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15390:14483"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..435
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65587.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       442..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          111 a          122 c          155 g          120 t
ORIGIN      
        1 acatggggct ctgagagagg agccttagcc ctggatttca aggcacttcc acctggggat
       61 cagcactgaa cacagaggac ccaccatgga gttggggctg agctgggttt tccttgttgc
      121 tattttaaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggag gcttggtcca
      181 gcctggaggg tctctgagac tctcctgtgt agcctctgga ttcagcttca gaagttacga
      241 aatgagttgg gtccgccagg ctccgggaaa ggggctggag tgggtctcat atattagtca
      301 cactggtgaa accatatacc acgctgactc cgtgaagggc cgattcacca tctccagaga
      361 caacgccaag aattcgctgt ctctgcaaat gagcagcctg agagccgagg acacggccct
      421 atattactgt actagaaacc ggaatactgt aatgattggg tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007106             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9278:9198
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007106
VERSION     KCXD01007106.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9278:9198"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65588.1"
                     /translation="CARDEGEISGFRFGYW"
     D_segment       453..459
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          115 a          108 c          163 g          124 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgaa actctcctgt gcagcctctg gattcacctt cagtagttat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tttgatggaa gtaagaaata ctacggagac tctgtgaagg accgattcat catctctaga
      361 gacaattcca agaacatgtt atatcttcaa atgaacaacc tgagattgga ggacacggcc
      421 atgtattact gtgcgaggga tgagggggag attagtgggt tccgatttgg ctactggggc
      481 cagggagtcc gggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007107             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18611:5197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007107
VERSION     KCXD01007107.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18611:5197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..510
     V_segment       141..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65589.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       450..462
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          106 a          124 c          156 g          126 t
ORIGIN      
        1 acatggggtc taggagagga gcccagccct gggattccca ggtgttgtca tttgtgatca
       61 gcactgaaca cagaagactc atcatggagt ttggcctgag ctgggttttc cttgttgcta
      121 ttttaaaagg tgtccagggt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt gactactgga
      241 tgtactgggt tcgccagaca cctgagcggg ggctggagtg gatctcagct attgatagtg
      301 ctggtactag taccacatac catgcagact ccgtgaaggg cagattcacc atctccagag
      361 agaacgccaa aaacacactg tatcttcaga tggacagcct gagaactgag gacacggctg
      421 tctattactg tgcgagagtt ccgggcctcg tggtatttac tggttcgctt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007108             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21081:16341
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007108
VERSION     KCXD01007108.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21081:16341"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..283
     V_segment       8..213
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <205..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65590.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       223..229
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       239..283
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           65 a           70 c           88 g           62 t
ORIGIN      
        1 acatggggtc actacttcat gagctgggtc cgccaggctc cagggaaggg actggagtgg
       61 atctcaggga ttaacagtgg tggagatacc acacactatg cagactccgt gaagggcaga
      121 ttcaccatgt ccagagagaa cgccaagaat atagtgtctc ttcaaatgga cggcctgaga
      181 gctgaggact cggctgtcta ttactgtgcg agagatcgac gtgtacagtc gttatcctgg
      241 ttcgatgtct ggggcccggg agtcctggtc accgtcgcct cagcc
//
LOCUS       KCXD01007109             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11955:9230
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007109
VERSION     KCXD01007109.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11955:9230"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..490
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65591.1"
                     /translation="CASGPSGYWNDWYFDIW"
     D_segment       432..442
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>493
                     /gene="IGHG"
BASE COUNT          120 a          141 c          136 g           96 t
ORIGIN      
        1 acatggggga catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctagtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaacta tccatgcact gggtgcgaca
      241 ggcccctgga aaaggacttc agtggatggg aagtgttgat cctgcatttg gtgaaatgat
      301 aaacgcagag aagttccagg acagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctatatggag ctgagcagcc tgagatctga ggacacggcc gtgtattatt gtgcgagtgg
      421 ccctagcggc tactggaacg actggtattt cgatatctgg ggccctggca ccccaatcac
      481 cgtctcctca acc
//
LOCUS       KCXD01007110             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:4185:10457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007110
VERSION     KCXD01007110.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:4185:10457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65592.1"
                     /translation="CAISSSGTWLFWYFDVW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          117 a          143 c          131 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaagtt tccggataca ccttcaccga attatcattg cactgggtgc gccaggcccc
      241 tggaaaaggg cttgagtggg tgggaagtgt tgaccctgca tatggtgaaa tgatacacac
      301 agagatattc cagggcagaa tcaccatgac cgaggacacg tcaacagaca cagcctacat
      361 ggagctaagc agcctgagat ctgaggacac ggccgtttat tactgtgcga tatcatccag
      421 cggcacctgg ctattctggt acttcgatgt ctggggccct ggctccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007111             445 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:3774:16464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007111
VERSION     KCXD01007111.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 445)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 445)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:3774:16464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    161..443
                     /note="immunoglobulin heavy chain variable region"
     V_region        161..443
     V_segment       161..382
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>412
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65593.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       392..397
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..443
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        444..>445
                     /gene="IGHG"
BASE COUNT          103 a          102 c          132 g          108 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgctgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggattca ccttcagtac
      181 ctttggcatg cactgggtcc gccaggctcc agggatgggg ctggagtggg tggcagttct
      241 atcttccgat ggaaataaga tatactacgc agactctttg aaggaccgat tcaccatctc
      301 cagagacaat tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac
      361 ggccgtatat tactgtgtgc gagatgtcag gggaacgggg tttgactatt ggggccaggg
      421 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007112             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9630:3065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007112
VERSION     KCXD01007112.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9630:3065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65594.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          112 c          154 g          121 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aagacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctactttaa gaggtgtcca gtgtgacgtg caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagtttt
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaaata ttacgcagac tctgtgaagg accgattcac cctctccaga
      361 gacaattcca agaatatgct atatcttcaa atgaacaacc tgaaactgga ggacacggcc
      421 gtgtatttct gtgtgagaga tgttagggga acggggtttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007113             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18881:11954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007113
VERSION     KCXD01007113.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18881:11954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65595.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          116 a          144 c          131 g           90 t
ORIGIN      
        1 acatgggggg catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg ggaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc acttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01007114             330 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:9095:19724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007114
VERSION     KCXD01007114.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 330)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 330)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:9095:19724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..328
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..328
     V_segment       7..258
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>297
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65596.1"
                     /translation="CAREEGEASGYRFGYW"
     D_segment       274..282
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       286..328
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        329..>330
                     /gene="IGHG"
BASE COUNT           83 a           77 c           98 g           72 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgt acagcctctg gattcacctt cagtagctat
       61 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatca
      121 tatgatggaa gcaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga
      181 gacaattcca agaacatact atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      241 gtgtattatt gtgcgagaga agagggggag gctagtgggt accgatttgg ctactggggc
      301 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007115             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23251:8884
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007115
VERSION     KCXD01007115.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23251:8884"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65597.1"
                     /translation="CARWGDSQSIYFFDYW"
     D_segment       398..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           93 a          134 c          133 g          109 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtga
      181 ctctattagc agtagtaact ggtggaattg gatccgccag cccccaggga aagggctgga
      241 gtggattggg tatatcagtg gtactagtgg tagcaccgac tatcacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt accctgaagt tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg ggtgactccc agtccattta
      421 cttctttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007116             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21554:16249
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007116
VERSION     KCXD01007116.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21554:16249"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65598.1"
                     /translation="CARNRFMGIRPLAYW"
     D_segment       407..413
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           97 a          136 c          127 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtccagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtga
      181 ctccatcagt ggttactact ggaactggat ccgccaacca ccagggaagg gactggagtg
      241 gattgggtat atcgctggta gtagtgggag cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccatct attactgtgc gagaaataga tttatgggta taaggcctct
      421 tgcctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007117             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:21770:10512
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007117
VERSION     KCXD01007117.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:21770:10512"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..477
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65599.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       416..423
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..477
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          100 a          135 c          145 g           99 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gatgtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attcgccttc agaatgtatg ccctcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gggatcgtcc ctcttgttgg aacaacaaac tccgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagtc tacatggagt
      361 tgagcagcct gagatctgag gacacggcca tgtattactg tgcgagaggc ctgggtagca
      421 gcgcccactt tggtttggat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007118             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6508:9063
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007118
VERSION     KCXD01007118.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6508:9063"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65600.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       415..420
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          112 a          140 c          130 g           95 t
ORIGIN      
        1 acatggggac acacaaccac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gctcctcctc ttggtggcag cagctacagg cgcccactcc
      121 gaggtccagt tggtacagtc tggggttgag gtgaagaagc ctggggcctc cgtgaaaatc
      181 tcctgccagg cttctggata caccttaacc gaccactacc tgcactgggt gcgacaggct
      241 cctggagaag gacttgagtg gatgggaggt gttcatcctg aatttggtaa agtagactac
      301 acacagaagt tccaagacag agtcaccatc accgcggaca tgtcgacaga gacagtctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgt gacagtgggt
      421 ccctaccatt actttgactt ctggggccag ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007119             318 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:23534:16706
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007119
VERSION     KCXD01007119.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 318)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 318)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:23534:16706"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..316
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..316
     V_segment       5..255
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <247..>285
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65601.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       268..274
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..316
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        317..>318
                     /gene="IGHG"
BASE COUNT           82 a           77 c           86 g           73 t
ORIGIN      
        1 acatgggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taactatggc
       61 atacactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtct
      121 gatgcaagta agacatacta cgcaaactct gtgaaggacc gattcaccat attaagagac
      181 aattccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccgtc
      241 tattactgtg cgagagacga tatgggaagt ggctttgact actggggcca gggagtcctg
      301 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007120             287 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:13137:12066
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007120
VERSION     KCXD01007120.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 287)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:13137:12066"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    2..285
                     /note="immunoglobulin heavy chain variable region"
     V_region        2..285
     V_segment       2..212
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <204..>254
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65602.1"
                     /translation="CARDPQWQLELLYFDSW"
     D_segment       223..232
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       239..285
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        286..>287
                     /gene="IGHG"
BASE COUNT           64 a           88 c           78 g           57 t
ORIGIN      
        1 acatgggcaa ttcctactgg agctggatcc gccagccccc agggaagggg ctggaatgga
       61 ttggatatat cagtggtgat agtgggagca ccgactacaa cccctccctc aagagtcgag
      121 tcaccatttc aacagacacg tccaagaacc agttctccct gaagctgaac tctgtgacca
      181 ccgcggacac ggccgtgtat tactgtgcga gagaccccca gtggcagctg gagctcctct
      241 actttgactc ctggagccgg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007121             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:19797:10867
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007121
VERSION     KCXD01007121.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:19797:10867"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65603.1"
                     /translation="CARYDADDYGYYYLDYW"
     D_segment       403..424
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          140 c          129 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cccgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcacc agtagcttct ggaactggtg ccgccagccc ccagggaagg gactggagtg
      241 gattggatat atctctggtg ctactgggag taccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga actctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatgac gcggatgatt acggttatta
      421 ttaccttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007122             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:29028:12513
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007122
VERSION     KCXD01007122.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:29028:12513"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65604.1"
                     /translation="CARSPSGSWLYWYFDFW"
     D_segment       425..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          149 c          132 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaagtttccg gatacacctt caccgaattt tccatgcact ggctacgaca
      241 ggcccctgga aaagggcttg agtggatggg gggtgttgat cctgcttttg gtgaaatgat
      301 acacgcagag aaattccaga acagagtcac cctgaccgag gacacctcta cagacacagc
      361 ctacatggag ctgactagcc tgagatctga ggactcggcc gtgtattact gtgcgcgctc
      421 acccagcggc agctggctat actggtactt cgatttctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01007123             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20884:9401
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007123
VERSION     KCXD01007123.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20884:9401"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65605.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..418
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           95 a          140 c          136 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggatat atcagtgcta gtagtgggac caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca cgtccaagaa cctcttctcc ctgaacctga gctctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagagagaaa tactatagtg gtagttataa
      421 acacaactgg ttcgatgtct ggggcccggg agtcctggtc gccgtctcct cagcc
//
LOCUS       KCXD01007124             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9940:15312
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007124
VERSION     KCXD01007124.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9940:15312"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..415
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <407..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65606.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       416..421
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          114 a          143 c          129 g           92 t
ORIGIN      
        1 acatggggat cacacaacca ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggctcctcct cttggtggca gcagctacag gcgcccactc
      121 cgaggtccag ctggtacagt ctggggctga ggtgaagaag cctggggcct ccgtgaaaat
      181 ctcctgccag gcttctggat acaccttaac cgaccactac ctacactggg tgcgacaggc
      241 tcctggaaaa ggacctgagt ggatgggagg tattcaccct gagtatggta aagtagacta
      301 cacacagaag ttccgagaca gagtcaccat catcgcggac atgtcgacag agacagtcta
      361 catggagctg agcagcctga gatctgagga cacggccgtt tattactgtg tgacagtggg
      421 tccctaccat tactttgact tctggggcca gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007125             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11995:13294
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007125
VERSION     KCXD01007125.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11995:13294"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65607.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       415..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          110 a          142 c          137 g           92 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc tttctggtgc agtctggggc tgaggtgaag cagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacaccct caccgaagtg tccactcact gggtgcgaca
      241 ggcccccgga aaagggcttg agtgggtggg aagtgttgat cctgcatatg gtgaaatgaa
      301 gttccagggc agagtcatca tgaccgagga cacgtccaca gacacagcct acatggaatt
      361 gagcagccta agatctgagg acacggccgt gtattactgt gcgattggac ctaccggcag
      421 gtggaacggc tggtccttcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01007126             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:15159:6137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007126
VERSION     KCXD01007126.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:15159:6137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..517
     V_segment       142..433
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65608.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       453..464
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       476..517
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          111 a          123 c          161 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtatttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcac ctggtgcagt ctgggggcgg cttgacaaag
      181 cctggggggt ccctgagact ctcctgtgcg gcctccggat tcaccttcag tgactactat
      241 atggactggg tccgccaggc tccagggaag gggctggagt gggtctcacg aatcagtcat
      301 gatggtgata gcacatggta cgcagactcc gtgaagggca gatttaccat ttccagagag
      361 aatgccaaga acacactgtt tcttcaaatg gacagcctga gaagtgagga cacagccgta
      421 tattactgtg cgagagagcg ttttggggga attggggtga ttatcttcaa ctggatcgat
      481 gtctggggcc cgggagtcct ggtcaccgtc ccctcagcc
//
LOCUS       KCXD01007127             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18484:7137
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007127
VERSION     KCXD01007127.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18484:7137"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..411
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65609.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       415..427
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          109 a          105 c          139 g          121 t
ORIGIN      
        1 acatggggga agtccacagt gttccattcg gtgatcagca cagaacacag aggactcacc
       61 atgaagtttg ggctgagctg ggttttcctt gttgctattt taagaggtgt ccagtgtgag
      121 gtgcagctgg tggagtctgg aggaggcttg gttcagcctg gggggtccct gagactctcc
      181 tgtgtagtct ctggattcac cttcagtaac tttggcatgc actgggtccg ccgggctcca
      241 gggaaggggc tggattgggt ggcagttatg tcgtttgatg aaaatacgaa attctacgca
      301 gactctgtga aggaccgatt caccatctcc agagacaatt ccaagaacat gctatatctt
      361 caaatgaaca acctgaaatt ggaggacacg gccgtctatt actgtgcgag aggggaatac
      421 agtaactcta ttgactattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007128             328 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18852:2789
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007128
VERSION     KCXD01007128.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 328)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 328)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18852:2789"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..326
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..326
     V_segment       8..259
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <251..>295
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65610.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       266..273
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       281..326
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        327..>328
                     /gene="IGHG"
BASE COUNT           73 a           83 c           97 g           75 t
ORIGIN      
        1 acatgggggg gggtccctga gactctcctg cgcagcctct ggattcagct tcagttattt
       61 ctacatgagc tgggtccgtc aggctccagg aaaggggctg gagtggatct caagtattga
      121 caatggtggg actaccacaa attttgcaga ctccgtgagg ggcaggttca ccatctccag
      181 agagaacgcc aagaacacac tgtatcttca aatggacagc ctgagagctg aggacacggc
      241 tgtctattat tgtgcgagag cgcgcggggt gatcattaca tactttgact cctggggcca
      301 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007129             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:14024:5617
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007129
VERSION     KCXD01007129.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:14024:5617"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65611.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       436..443
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          123 a          142 c          140 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagccacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agttaagaag cctggggcct cagtgatggt
      181 ctcctgccag gtttccggat acaccgtcac cgaaatatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgctcct gaaaaaaatg agttaataca
      301 cgcagacaag ttccaggaca gagtcagcat gaccgaggac acgtctacag acacagccta
      361 catggagctg agtggcctga catttgagga cacggccgtg tattactgtg cgacccacgg
      421 aggttatagc gacatctgga actccctata taacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007130             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12324:16767
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007130
VERSION     KCXD01007130.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12324:16767"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65612.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          120 a          142 c          132 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaac cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttaac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 cttggagctg agcagtctga gatctgagga cacggccgtg tattactgtg cgacctcatc
      421 cagcggcacc tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007131             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:8848:16907
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007131
VERSION     KCXD01007131.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:8848:16907"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..497
     V_segment       144..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65613.1"
                     /translation="CATADYGNSLDYW"
     D_segment       441..452
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>500
                     /gene="IGHG"
BASE COUNT          114 a          119 c          147 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag tatgaaatac tacgcagact ctatgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaagaacct gaaattggag gacactgccg
      421 tctattattg tgcgacagcc gactacggta acagccttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcaacc
//
LOCUS       KCXD01007132             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20893:5071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007132
VERSION     KCXD01007132.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20893:5071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65614.1"
                     /translation="CARDAYGRGFDYW"
     D_segment       267..271
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           77 a           78 c           92 g           73 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
       61 gcattcactg ggtccgccag tctccaggga aggggctgga gtgggtggca gtgatttcgt
      121 acgatgaaac taagaaatac cacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggcct
      241 tgtattactg tgcgagagat gcgtacggga gggggtttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007133             373 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9020:14026
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007133
VERSION     KCXD01007133.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 373)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 373)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9020:14026"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..371
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..371
     V_segment       8..301
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>340
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65615.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       311..317
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       327..371
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        372..>373
                     /gene="IGHG"
BASE COUNT           82 a           89 c          119 g           83 t
ORIGIN      
        1 acatggggag gtgaagctgg tggagtctgg gggcggcttg gcaaagcctg gggggtccct
       61 gagactctcc tgcgcagcct ctggattcag cttcaattat tactacatga gctgggtccg
      121 ccaggctcca gggaaggggc tggagtggat ctcaggtatt aatagtggtg gggaaagcac
      181 atactctgca gactccgtga agggcagatt caccatctcc agagagaacg ccaagaacac
      241 gctatatctt gaaatggaca gcctgagaac tgaggacacg gctgtctatt attgtgtgag
      301 agatcgacgt gtacagtcgt tatcctggtt cgatgtctgg ggcccgggag ccctggtcac
      361 cgtctcctca gcc
//
LOCUS       KCXD01007134             357 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23358:18994
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007134
VERSION     KCXD01007134.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 357)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 357)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23358:18994"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..355
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..355
     V_segment       8..277
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65616.1"
                     /translation="CARGGNFWSGYSAGALDVW"
     D_segment       293..302
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       312..355
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        356..>357
                     /gene="IGHG"
BASE COUNT           77 a           82 c          122 g           76 t
ORIGIN      
        1 acatgggggg gctgaggtga agaagcctgg ggcctcagtg aaggtctcct gcaaggtttc
       61 cggatacacc ttcaccgaat tctccatcca ctgggtacga caggcccctg gaaaggggct
      121 tgagtggatg ggaggtgttg atcctatgaa tggtgaagca gttgcagaca agttccaggg
      181 cagagtcacc atgaccgagg acacgtctgc agacacagcc tacatggaac tgagcagcct
      241 gagatctgag gacacggccg tgtattactg tgcgagaggg gggaattttt ggagtggtta
      301 ttccgccggg gcattggatg tctgggccgg ggagttctgg tcaccgtctc gtcagcc
//
LOCUS       KCXD01007135             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:19342:14589
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007135
VERSION     KCXD01007135.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:19342:14589"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65617.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          109 a          144 c          134 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattatc catacactgg gtgcggcagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca cgtctgcaga cacagcctac atggacctga
      361 gtagcctgac atctgaggac acggccgtgt attactgtgc gactggccct agcggcacct
      421 ggaacgcctg gtacctcgat atctggggcc ctggcactcc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007136             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:8770:15355
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007136
VERSION     KCXD01007136.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:8770:15355"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65618.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          120 a          143 c          133 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga accctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacttggagc tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacctca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01007137             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13838:10317
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007137
VERSION     KCXD01007137.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13838:10317"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..484
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65619.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       423..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..484
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          104 a          137 c          145 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgat gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggatt cgccttcaga atgtatgccc tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcgtccctc ttgttggaac aacaaactcc
      301 gcacagaagt tccagggcag agtcacgatt accgcggaca cgtccacaag cacagtctac
      361 atggagttga gcagcctgag atctgaggac acggccatgt attactgtgc gagaggcctg
      421 ggtagcagcg cccactttgg tttggattcc tggggccaag gggtcgtcgt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01007138             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20540:8349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007138
VERSION     KCXD01007138.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20540:8349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..404
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65620.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       418..428
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..479
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          109 a          146 c          133 g           93 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaagtc cagctggtgc agtctggggc tgatgtgaag aagcctgggg cctcagtgag
      181 ggtctcctgc aggatttccg gatacacctt caccgaatta tccatacact gggtgcggca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctgtatg gtgaaatgaa
      301 gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct acttggaact
      361 gagcggcctg acttctgagg acacggccgt gtattactgt gcgactggcc ctaccggcac
      421 ctggaacgcc tggtacctcg atatctgggg ccctggcacc ccaatcacca tctcctcagc
      481 c
//
LOCUS       KCXD01007139             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:8378:23597
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007139
VERSION     KCXD01007139.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:8378:23597"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65621.1"
                     /translation="CAGRTWSGGTPLLDYW"
     D_segment       428..435
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           93 a          135 c          135 g          107 t
ORIGIN      
        1 acatggggga atgctctctg agagtcacgg acatcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gtagctccca gatgggtcct gtcccaggtg cagctggagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc actgtctctg
      181 gtttctccat cagcagtgac tactggagct ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatatat ggaagaagtg ggagcatcta ctataatccc tccctcaaca
      301 gtcgagtcac cttttcaaca gacacgtcca agaaccagtt ctccttgaag ctgaactctg
      361 tgaccgccgc agacgcggcc gtttattact gtgcggggcg gacctggagt ggtggcacgc
      421 ccctccttga ttattggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007140             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6594:18141
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007140
VERSION     KCXD01007140.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6594:18141"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65622.1"
                     /translation="CARWGDSQSIYYFDYW"
     D_segment       398..405
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          139 c          131 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acatgcgctg tctctggtgg
      181 ctctattagc agtactaact ggtggaactg gatccgccag cccccaggga aaggcctgga
      241 gtggattggg tatatcagtg gtactagtgg tagcaccgac tatcacccct ccctcaagag
      301 tcgagtcacc atttcaccag acacgtccaa aaaccagttt accctgaggt tgacctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg ggtgactccc agtccattta
      421 ctactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007141             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:19019:19242
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007141
VERSION     KCXD01007141.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:19019:19242"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65623.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       446..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          113 a          122 c          154 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacaa aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgaa gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca attattacta
      241 catgagctgg gtccgccagg ctccagggaa ggggctggag tggatctcaa gtattaatag
      301 tggtggggaa agcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactat atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgtaca gtcgttatcc tggttcgatg tctggggccc
      481 gggagccctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007142             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:17144:13003
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007142
VERSION     KCXD01007142.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:17144:13003"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65624.1"
                     /translation="CANVLGPWGSWSHYFDYW"
     D_segment       413..422
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           95 a          143 c          136 g          100 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ctcttcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccctcagag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatcg gtagttactg gtggacctgg gtccgccagc ccccagggaa gggactggag
      241 tggattgggg agatcaatgg aaatagtggt agtacctact acagcccatc cctcaagagt
      301 cgagtcacca tttcaaaaga cgcgtccaag aaccacctct ccctgaagct gaattctgtg
      361 accaccgcgg acacggccgt gtattactgt gcgaacgtct taggcccctg gggcagctgg
      421 tcacactact ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007143             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12322:15398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007143
VERSION     KCXD01007143.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12322:15398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..482
     V_segment       113..406
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65625.1"
                     /translation="CAREYCTSTDCAGFFDFW"
     D_segment       407..416
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          112 a          131 c          133 g          108 t
ORIGIN      
        1 acatggggaa ccacatcctc ctctaaagaa gcccctggga gcacagctca tcaccatgga
       61 ctggacctgg aggctcctct ttgtggtggc agcagctaca ggtgtccagt cccaggtcca
      121 gttggtgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg tttcctgcaa
      181 ggcttctgga ttcaccttcg acaactatgg tatcaactgg gtgcgacagg cccctggaca
      241 ggggcttgag tggatgggag taaccatccc ccttgttggt ataatcaact acagagacaa
      301 cgtccaggac agagtcacca tttccgcgga cacgtccaca aacacagcct acatggagat
      361 aaacagcctg agatctgacg acacggccat ctattactgt gcgagagaat attgtacttc
      421 tactgattgc gccggatttt ttgacttttg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01007144             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17671:14987
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007144
VERSION     KCXD01007144.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17671:14987"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..484
     V_segment       112..408
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65626.1"
                     /translation="CARQCCYYDDFLDYFDFW"
     D_segment       416..423
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT           97 a          136 c          139 g          114 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcatggacc tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag
      121 ctgcaggagt cgggcccagg actggtgaag ccttcagaga ccctgtccct cacctgcgct
      181 gtctctggag gctctctcag cggtggttat gactggagct ggatccgcca gcccccaggg
      241 aaggggctgg agtggattgg ctatatctat ggtggtactg ggagcaccac ctacaacccg
      301 tccctcagga atcgagtcac catttcaaaa gacacgtcca agaaccagtt gtccctgaag
      361 ctgagctctg tgaccgccgc ggacacggcc gtatattatt gtgcgagaca gtgctgttac
      421 tatgatgact ttttagacta ctttgacttc tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01007145             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13141:21630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007145
VERSION     KCXD01007145.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13141:21630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..487
     V_segment       126..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65627.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       417..423
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>491
                     /gene="IGHG"
BASE COUNT          117 a          144 c          130 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggctacacct tcgccgaatt gcccatacac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggttttgc ttctatatat ggtgaaataa
      301 tacatacaga gagattccag ggcagagtca ccatgacagc ggacacgtct atagacacag
      361 cctacatgga actcagcagc ctgacatctg aggacacggc cgtgtattac tgtgcggcag
      421 ctgatagtgg ttacccattt tactacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctccgc c
//
LOCUS       KCXD01007146             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:4710:12410
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007146
VERSION     KCXD01007146.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:4710:12410"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <425..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65628.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       439..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..503
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          108 a          130 c          149 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagca ctggaagtcc acagtgttcc attcggtgat
       61 cagcactgaa cacagaggac tcaccatgga gtctgggctg agctggcttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca ggtggaggag tctgggggcg gcttggcaaa
      181 gcctggggga tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgc
      241 tatgcattgg gtccgccagg ctccagggaa ggggctgaaa tgggtctcat ctattagtag
      301 tggtggtctc acatactacg cagactccgt gaagggccga tttgccatct ccagagacaa
      361 ctcaaagaac acgctctccc tgcaaatgaa cagcctgagc gctgaggaca cggccgtata
      421 ttactgtgcg aaaggaggta gcagctcttt ctattggtac ttcgatatct ggggccctgg
      481 caccccagtg accatctcct cagcc
//
LOCUS       KCXD01007147             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:11484:5838
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007147
VERSION     KCXD01007147.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:11484:5838"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65629.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          140 c          151 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgaaatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01007148             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:11997:10001
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007148
VERSION     KCXD01007148.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:11997:10001"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..492
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65630.1"
                     /translation="CARGYCTGNGCNLTFNRLDVW"
     D_segment       411..421
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..492
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          139 c          145 g          106 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga accccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacagcttc agcatctatg tcatcagttg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg attaccgcgg acacggccac aagcacagcc tacatggacc
      361 tgagcagcct gggatctggg gacacggccg tgtattattg tgcgagaggt tactgtactg
      421 gcaatggttg taaccttact ttcaaccggc tcgatgtctg gggcccggga gtcccggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007149             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:18258:1969
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007149
VERSION     KCXD01007149.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:18258:1969"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    82..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        82..456
     V_segment       82..381
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <370..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65631.1"
                     /translation="CARIQGGSYYYGGGYFEFW"
     D_segment       386..402
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..456
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           99 a          139 c          116 g          104 t
ORIGIN      
        1 acatggggac tcctgtgccc caccatggac acgctttgct acacactcct gctactgacc
       61 gtcccgtcct gggtcttgtc ccaggtgacc ttgaaggagt ctggtcctgc gctggtgaaa
      121 cccacacaga ccctcacgct gacctgcacc ttctctgggt tctcaatcag tacttctgca
      181 acaggtgtgg gctggatccg tcagccccca gggaaggccc tggaatggct tgcaagcatt
      241 tattggaatg atactaaatt cttcagcact tcgctgaaga gcagactcac cgtctccaag
      301 gacacctcca aaacccaggt ggttctaaca atagccaaca tggaccctgt ggacacagcc
      361 acatattact gtgcacggat acagggtggt agttactact acggtggggg atacttcgag
      421 ttctggggcc agggcgcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007150             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:19692:6756
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007150
VERSION     KCXD01007150.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:19692:6756"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    97..448
                     /note="immunoglobulin heavy chain variable region"
     V_region        97..448
     V_segment       97..386
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65632.1"
                     /translation="CASNSITSGPDYW"
     D_segment       392..398
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..448
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        449..>450
                     /gene="IGHG"
BASE COUNT           90 a          138 c          123 g           99 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgc aagaacatga ggcacctgtg gttcttcctc
       61 ctcctggcgg cagctcccag atgggtcctg tcccgcctgc agctgcaggc gtcgggccca
      121 ggactggtga agccttcgga gaccctgtct ctcacctgcg ctgtctctgg tgcctctatc
      181 agcggtaact actggagctg gatccgccag gccccaggga agggactgga gtggattgga
      241 tatatctatg gtagtgatat tagtaccaac tacaacccct ccctcaagag tcgagtcacc
      301 ctgtcagtag acacgtccaa gaaccagttc tccctgaacc tggcctctgt gaccgccgcg
      361 gacacggcca tctatttctg tgccagtaac agtataacat ctggtccaga ctattggggc
      421 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007151             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:19781:14567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007151
VERSION     KCXD01007151.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:19781:14567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65633.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       403..414
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          141 c          137 g          104 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gcctttggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaacta ctgggcctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtatctctgg tagtggtggg agcaccgtct acaacccctc cctcaagagt
      301 cgagtcacca tttcaactga cacgtccaag aaccaggtct ccctgaaagt gacttctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgacagccg gatatagcag cagcgaaagc
      421 ttctacggtt tggattcctg gggccaaggg gtcgtcgtca tcgtctcctc agcc
//
LOCUS       KCXD01007152             426 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:15734:4523
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007152
VERSION     KCXD01007152.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 426)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 426)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:15734:4523"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    58..424
                     /note="immunoglobulin heavy chain variable region"
     V_region        58..424
     V_segment       58..348
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <343..>393
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65634.1"
                     /translation="CAGGYSGRWISWSFALW"
     D_segment       355..365
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       382..424
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        425..>426
                     /gene="IGHG"
BASE COUNT           94 a          113 c          130 g           89 t
ORIGIN      
        1 acatggggga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
       61 gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gagggtctcc
      121 tgcaaggtct ccggatacac cttcaccgga ttatccatac actgggtgcg acaggcccct
      181 ggaaaagggc ttgagtggat gggaggcgtt gatcctgtat atggtgaaat aatacacaca
      241 gagaggttcc agggcagagt caccttgacc gaggacacgt ctacagacac agcctacatg
      301 gaactgaaca gcctgagatc tgaagacatg gccatttatt actgtgcggg cggatatagc
      361 ggcaggtgga tctcttggtc gttcgctctc tggggccctg gcaccccaat caccatctcc
      421 tcagcc
//
LOCUS       KCXD01007153             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:25266:10034
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007153
VERSION     KCXD01007153.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:25266:10034"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65635.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       440..452
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          116 c          147 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc atccggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gttggtggag tctggaggag gcttggttca
      181 gcctggaggg tccctgagac tctcctgtac agcctctgga ttcaccttca gtcactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggat tgggtggcag ttatgtcgtt
      301 tgatgaaaat gtgaaattct acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccct
      421 gtattactgt gcgagagggg aatacagtaa ctctattgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007154             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:14225:16259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007154
VERSION     KCXD01007154.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:14225:16259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65636.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       437..446
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          107 a          120 c          153 g          114 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtggctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcgacct ctggattcac cttcagtcgc tttggcatgc
      241 actgggtccg ccaggctcca ggggaggggc tggagtgggt ggcagtcata tcgtctgatg
      301 aaaataacaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaacgacat gttatatctt cacatgaacg acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgcg agacgtctac ggtagcggac ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007155             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18027:18787
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007155
VERSION     KCXD01007155.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18027:18787"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65637.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       429..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          115 a          133 c          147 g           98 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggccccagga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgaaataat
      301 tgtcgcagag aatttccagg acagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tggaatctga ggacacggcc gtgtattact gtgcgaaagg
      421 gaggagtggt ggtgtctggc cgagctcctt cgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007156             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18255:12302
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007156
VERSION     KCXD01007156.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18255:12302"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65638.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          114 c          150 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga gcacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactatg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggcct
      421 tgtattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007157             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:22489:11827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007157
VERSION     KCXD01007157.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:22489:11827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..464
     V_segment       111..401
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65639.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       411..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          132 c          136 g          107 t
ORIGIN      
        1 acatggggat gggaaatgtt ctctgagagt cacggacatc ctgtgcaaga acatgaagca
       61 cctgtggttc ttcctcctcc tggtggcagc tcccagatgg gtcctgtccg agctacagct
      121 gcaggagtcg ggcccaggac tggtgaagcc ttcggagacc ctgtctgtca cctgcgctgt
      181 ctctggtgac tctatcagca gttatttctg gaattggatc cgccaggccc cagggaaggg
      241 actggagtgg attgggtttc tctatggtag tgatagtacc tccaactaca acccctccct
      301 caagagtcga gtcaccctgt cagtggacac gtccaagaac caggtctccc tgatgctgag
      361 ctctgtgacc gccgcggaca cggccgtcta ttactgtgcg accgggaaga ggcagctgga
      421 tcttgactat tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007158             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10440:4195
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007158
VERSION     KCXD01007158.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10440:4195"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..464
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65640.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>468
                     /gene="IGHG"
BASE COUNT           94 a          136 c          132 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagaagtta ctggaactgg atccgccagc ccccagggaa gggtctggag
      241 tggattgggt ctatctatgg tggtactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaaact gacctctgtg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg aggatgaata tagtgactat
      421 cactttgact actggggcca gggagtcctg gtcgccgtct cctcggcc
//
LOCUS       KCXD01007159             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15803:19570
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007159
VERSION     KCXD01007159.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15803:19570"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65641.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           92 a          131 c          138 g           98 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgag gcatctgtgg
       61 ttcttcctcc tcctggtggc aggtcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcga tgtctctggg
      181 ggctccatca gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtgtatcta cgatagtagt ggaaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gatgaggtct
      361 atgaccgccg cggacgcggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007160             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20846:5078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007160
VERSION     KCXD01007160.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20846:5078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65642.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       416..427
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          119 a          141 c          134 g           96 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caggtggtgc agtctggggc tgaggtgaag gagcctgggg cctcagcgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctctatatg gtgaaatgaa
      301 acacacagag ttccatgcca gattcaccat gaccgaggac acgtctacag acacagccta
      361 catggagttg agcagcctaa gatctgagga cacggccctg tattattgtg cagtcgggta
      421 tagcggccga tggaacaact ggtacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007161             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:27467:11009
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007161
VERSION     KCXD01007161.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:27467:11009"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65643.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       430..434
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          107 a          111 c          152 g          121 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatatct ggcatgcact
      241 gggtccgcca ggctccaggg aaggggctgg agtgggtgtc agttatatcg tctgatggaa
      301 gtaagaaata ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcaa
      361 aaaacatggt ttatcttcaa atgaacaacc tgaagttgga ggacacggcc gtgtatttct
      421 gtgtgagaga tgccttcggg ggcggtttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01007162             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22348:11179
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007162
VERSION     KCXD01007162.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22348:11179"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    111..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        111..477
     V_segment       111..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65644.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       410..416
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          107 a          135 c          137 g          100 t
ORIGIN      
        1 acatgggggc cacatccctc ccctacagaa gccccagagc acagcacctc accatggact
       61 ggacctggag gatcctcctc ttggtggcag cagctgcagg cgcccgctct gaggttcagt
      121 tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc tcctgcgagg
      181 tttccggata caccttcacc gaactgtcca tccactgggt gcgacaggcc cctggaaaag
      241 gccttgagtg gatgggaagt gttgatcctg aatatggtga aatgataaac gcagaaaagt
      301 tccagggcag agtcaccttg accgaggaca cgtctacagg aacggcctac atggagctga
      361 tcagcctgag atctgaagac acggccgtgt attactgtgc gacatcaccc agcggcaatt
      421 ggcttttttg gtacttcgat ttttggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007163             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16311:12708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007163
VERSION     KCXD01007163.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16311:12708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65645.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          115 a          140 c          151 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgacc ctgcaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 gggttcggta gcagtgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgccgtca ccatctcctc agcc
//
LOCUS       KCXD01007164             353 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20465:2984
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007164
VERSION     KCXD01007164.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 353)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 353)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20465:2984"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..351
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..351
     V_segment       1..284
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>320
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65646.1"
                     /translation="CAATGEPLEYFDFW"
     D_segment       293..297
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       302..351
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        352..>353
                     /gene="IGHG"
BASE COUNT           71 a          101 c          106 g           75 t
ORIGIN      
        1 tgcaggagtc gggcccagga gtggtgaggc cttcagagac cctgtccctc acctgcgctg
       61 tctctggagg atctatcagc agtggttatg actggagctg gatccgccag cccccaggga
      121 aggggctgga gtggattggg tatatctatg gtactagtgg gagcaccaac tacaatgcgt
      181 ccctcaagaa tcgagtcacc atttcaaaag acgcgtccaa gaaccagttc tccctgcagt
      241 tgaggtctgt gaccgccgcg gacacggccg tttattactg tgcggcgaca ggggaacccc
      301 ttgaatactt cgacttctgg ggccagggcg ccctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007165             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:15397:7119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007165
VERSION     KCXD01007165.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:15397:7119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65647.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       445..450
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          105 a          115 c          160 g          122 t
ORIGIN      
        1 acatgggggg agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tgctatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggtttggt
      181 tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct tcagtatctc
      241 tggcatgcac tgggtccgcc aggctccagg gcaggggctg gattgggtgg cagttgaatc
      301 gtttgatgga ggtaagaaat actacgctga ctctgtgaag gaccgattca ccatctccag
      361 agacaattcc aagaacatgc tatatcttca aatgagcaac ctgaaattgg aggacacggc
      421 cgtgtattac tgtgtgagag atgcctacgg gggcggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007166             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12804:16792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007166
VERSION     KCXD01007166.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12804:16792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..478
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65648.1"
                     /translation="CARGRIHLQFMDSW"
     D_segment       427..434
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          112 a          133 c          137 g           98 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagcgcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgtaagg cttctggata caccttcaac atgtttgcca tcaattgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg aacatccctc ttgttgatat aacaaagtac
      301 gcacagaagt tccaggacag agtcacattt accgcggaca cgtccactag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgttt attactgtgc gagagggagg
      421 attcacctac agttcatgga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007167             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18678:7307
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007167
VERSION     KCXD01007167.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18678:7307"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65649.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       405..413
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           92 a          138 c          137 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga cgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tctcctgcac tgtctctggt
      181 ggctccttca gtggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ttatcggtgg tggtagtggg agcaccgaat acaacccctc cctcaaaagt
      301 cgagtcacca tttcaagaga cacgtccaag aatcaattct ccctgaagct gacctctatg
      361 gccgccgcgg acacggccgt ttatttctgt gccagagatg cgggagtggg agccacaatc
      421 ctttactact atgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007168             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:15746:14364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007168
VERSION     KCXD01007168.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:15746:14364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..472
     V_segment       112..405
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65650.1"
                     /translation="CARNRGVLLPYFDFW"
     D_segment       415..420
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           94 a          138 c          134 g          108 t
ORIGIN      
        1 acatggggac atgggaaatg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagttgcaa
      121 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct
      181 gtctctggtg gttccatcag cagtatctac tggagctggt tccgccagcc cccagggaag
      241 ggactggagt gggttggacg tatctctggt agtagtggga gcaccgacta caacccctcc
      301 ctcaagagtc gagtcaccat ttcaacagac acgtccaaga gtcagttctc cctgaagctg
      361 aactctgtga ccgccgcgga cacggccgtg tattattgtg caagaaacag gggggtactt
      421 ctcccctact ttgacttctg gggccaggga gtcctggtca ccgtttcctc agcc
//
LOCUS       KCXD01007169             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8173:10264
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007169
VERSION     KCXD01007169.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8173:10264"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65651.1"
                     /translation="CARDPQWQLELLYFDSW"
     D_segment       405..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          145 c          131 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtgg
      181 ctcgttcagc aattcctact ggagctggat ccgccagccc ccagggaagg ggctggaatg
      241 gattggatat atcagtggtg atagtgggag caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga actctgtgac
      361 caccgcggac acggccgtgt attactgtgc gagagacccc cagtggcagc tggagctcct
      421 ctactttgac tcctggagcc ggggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007170             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10265:2516
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007170
VERSION     KCXD01007170.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10265:2516"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65652.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       267..272
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           76 a           74 c           93 g           77 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgta cagcctctgg attcatgttc agtaactatg
       61 gcatccactg ggtccgccag gctccaggga aggggctgga gtgggtgtca gttatatcgt
      121 atgatgtaac tgtgaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      181 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      241 tgtattattg tgtgagggat gtcaggggaa cggggtttga cttctggggc cagggagtcc
      301 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01007171             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14914:10139
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007171
VERSION     KCXD01007171.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14914:10139"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65653.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       438..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          114 c          149 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttcctttttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taagaaatac tacgcaaatt ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattattg tgcgagagat gatcttggga ccggttttga ctactggggc cagggaatcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007172             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:10830:7714
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007172
VERSION     KCXD01007172.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:10830:7714"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..503
     V_segment       122..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65654.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       424..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       470..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          142 c          145 g          104 t
ORIGIN      
        1 acatggggca cataacaacc acgtccctcc tctaaagaag cccctgggaa cacagctcat
       61 caccatggac ttgacctgga ggctcctctt tgtggtggca gcagctacag gtgcccagtc
      121 ccaggtccag ttggtgcagt ccggggctga ggtgaagagg cctggggcct cagtgaagct
      181 ctcctgcaag gctcctggat acatcttcag catatctgcc atcagttggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggagg gatcatccct cttgttggtg taacaaccta
      301 cgcacagaac ttccaggaca gagtcacgat taccgcggac acgtccacaa gcacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tatttctgtg cgagtggcgg
      421 cttcgaggat gataacggtc actattatac gacactaaca tttcacgagt ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007173             397 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15907:13572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007173
VERSION     KCXD01007173.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 397)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 397)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15907:13572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    35..395
                     /note="immunoglobulin heavy chain variable region"
     V_region        35..395
     V_segment       35..328
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <320..>364
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65655.1"
                     /translation="CARVAGVIIIYFDYW"
     D_segment       333..348
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       349..395
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        396..>397
                     /gene="IGHG"
BASE COUNT           73 a          117 c          122 g           85 t
ORIGIN      
        1 acatggggtg gcagctccca gatgggtcct gtcccaggtg cagctgcaag agtcgggccc
       61 aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg gtggctcctt
      121 ccgcggtcgc cactggggct ggatccgcca gcccccaggg aagggactgg agtggattgg
      181 acgtatcgat ggtagtggtg ggagcaccga ctacaacccc tccctcaaga gtcgagtcac
      241 catttcaaca gacacgtcca agaatcagtt ctccctgaac ctgaggtctg tgaccgccgc
      301 ggacacggcc gtgtattact gtgcgagagt cgctggggtg ataattatct actttgatta
      361 ttggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007174             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13604:6516
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007174
VERSION     KCXD01007174.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13604:6516"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65656.1"
                     /translation="CARTDCTGGVCYFDYW"
     D_segment       451..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          112 a          113 c          161 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gaactgggtt gtccttgttg
      121 gtattttaag aggtgtccgg tgtgaagtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgaactg ggtccgccag gctccaggga aggggctgga gtgggtggga gttatatcgt
      301 ttgaaggaag taagaaatac tacgcagact ctatgaagga ccgattcacc ctctccagag
      361 acaattccaa gaacaggcta tatcttcaaa tgggcaacgt gaaattggag gacgcggccg
      421 tctatttctg tgcgagaacg gattgtactg gtggtgtctg ctactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007175             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18410:9076
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007175
VERSION     KCXD01007175.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18410:9076"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..508
     V_segment       145..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65657.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       444..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          113 a          121 c          156 g          120 t
ORIGIN      
        1 acatggggag ctctgagaga ggagccttag ccctggattt caaggcactt ccacctgggg
       61 atcagcactg aacacagagg acccaccatg gagttggggc tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg aggcttggtc
      181 cagcctggag ggtctctgag actctcctgt gtagcctctg gattcagctt cagaagttac
      241 gaaatgagtt gggtccgcca ggctccggga aagggactgg agtgggtctc atatattagt
      301 cacactggtg aaaccatata ccacgctgac tccgtgaagg gccgattcac catctccaga
      361 gacaacgcca agaattcgct gtctctgcaa atgagcagcc tgagagccga ggacacggcc
      421 gtatattact gtactagaaa ccggaatact gtaatgattg ggtggttcga tgtctggggc
      481 ccgggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007176             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:12544:3883
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007176
VERSION     KCXD01007176.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:12544:3883"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65658.1"
                     /translation="CATGPSGTWNAWYLDIW"
     D_segment       415..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          109 a          142 c          136 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga ggccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt
      181 ctcctgcaag gtttccggat acagcttcac cgaattatcc atacactggg tgcggcaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctgcagac acagcctaca tggaactgag
      361 tagcctgaca tctgaggaca cggccgtgta ttactgtgcg actggcccta gcggcacctg
      421 gaacgcctgg tacctcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01007177             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:27775:17252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007177
VERSION     KCXD01007177.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:27775:17252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..400
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <392..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65659.1"
                     /translation="CARVSGYSSLYFYTFESW"
     D_segment       407..415
                     /gene="IGHD5-31"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..476
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           95 a          137 c          134 g          112 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca gcagtggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgcctccatc agcagtagta actggtggag ctggatccgc cagtccccag tgaaggggct
      241 ggaatggatt gggggtctct atggtagtgg tgggaacacc gaatacaacc cctccctcaa
      301 gagtcgagtc accatttcaa aagacacgtc caagaaccac ttctccctga acctgaattc
      361 tgtgaccgcc gcggacaccg ccgtgtatta ctgtgcgaga gtttccggat atagcagcct
      421 gtatttttat actttcgaat cgtggggccg aggggtcgtc gtcatcgtct cttcagcc
//
LOCUS       KCXD01007178             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18412:5770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007178
VERSION     KCXD01007178.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18412:5770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65660.1"
                     /translation="CTKGRSGGVWPNSFDYW"
     D_segment       429..438
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          117 a          135 c          142 g           99 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcatagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgattta tccatgcact gggtgcgaca
      241 ggccccagga aaagggcttg agtggatggg aagtgttgat cctgtatatg gtgaaataat
      301 tgtcgcagac aatttccagg acagagtcac catgaccgag gacacgtcta ccgacacagc
      361 ctacatggag ctgagcagcc tggaatctga cgacacggcc atgtattact gtacgaaagg
      421 gaggagtggt ggtgtctggc cgaactcctt tgactactgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007179             293 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7314:19336
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007179
VERSION     KCXD01007179.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 293)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 293)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7314:19336"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..291
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..291
     V_segment       8..216
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <210..>260
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65661.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       230..236
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..291
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        292..>293
                     /gene="IGHG"
BASE COUNT           72 a           77 c           81 g           63 t
ORIGIN      
        1 acatgggctt caccgaatta tccatgcact gggtgcgaca ggcccctgga aaagggcttg
       61 agtggatggg aagtgttgat cctgtgtatg gtgaaataat aaattcagag aagttccagg
      121 gcagagtcac cttgaccgag gacacgtcta cagacacagc ctacatggag ctgagcagcc
      181 tgagatctga ggatacggcc gtgtattact gcgcgacatc atccagcggc acctggctat
      241 actggtactt cgatgtctgg ggccctggca ccccaatcac catctcctca gcc
//
LOCUS       KCXD01007180             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19159:22882
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007180
VERSION     KCXD01007180.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19159:22882"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..318
     V_segment       8..231
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <225..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65662.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       250..260
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       273..318
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           76 a           82 c           92 g           70 t
ORIGIN      
        1 acatgggggt ttccggatac accgtcaccg aattatccat gcactgggtg cgacaggccc
       61 ctggacaagg gcttgagtgg atgggacttg ttgatcctgt aaatggtgaa ctaatacacg
      121 cagacaagtt ccagggcaga gtcaccatga ccgaagacac gtctacagac acagcctaca
      181 tggagttgag cagcctgaca tctgaggaca cggccattta ttactgtgcg acagggagga
      241 tcggtaccag tggctggtcc aacctcttca atggtttgga ttcctggggc caaggggtcg
      301 tcgtcaccgt ctcttcagcc
//
LOCUS       KCXD01007181             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:10435:10635
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007181
VERSION     KCXD01007181.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:10435:10635"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65663.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       441..448
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..505
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          108 a          130 c          151 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg cggcttggcg
      181 aagcctgggg gatccctgag actctcctgt gcagcctctg gattcacctt caatacctat
      241 gctatgcact gggtccgcct ggctccaggg aaggggctgg agtgggtctc agctattagt
      301 agtggtggta gcacatacta cgtagactcc gtgaagggcc gattcaccat ctccagagac
      361 aactcaaaga acacgctctc cctgcaaatg aacagtctga gagatgagga cacggccttt
      421 tattactgtg cgaaaggagg tagcagctct ttctactggt acttcgatat ccggggccct
      481 ggcaccccag tcaccatctc ctcagcc
//
LOCUS       KCXD01007182             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:7408:17289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007182
VERSION     KCXD01007182.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:7408:17289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65664.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       439..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          115 c          156 g          117 t
ORIGIN      
        1 acatgggagc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacttttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttacatcgtc
      301 tgatgaaagt aagaaatact acgcagactc tgtgaaggcc cgattcaccg tctccagaga
      361 caaatccaag aacatgttat atcttcaaat ggacaacctg aaattggaag acacggccgt
      421 ctattactgc gcgagagatg tctgggggag gggatttgac tattggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007183             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22982:5630
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007183
VERSION     KCXD01007183.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22982:5630"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65665.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       434..438
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          123 c          158 g          115 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactcaac acagaacata ccatggagta tgtgctgagt tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggattc aacttcaatt actactacat
      241 gaactgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttaacagtgg
      301 tggggatagc acatactatg cggactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagtggtgg gtggtgccgc aggatacttc gacttctggg gccagggcgc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007184             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:16300:9446
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007184
VERSION     KCXD01007184.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:16300:9446"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..482
     V_segment       113..406
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65666.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       415..423
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           98 a          137 c          140 g          109 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcatggac atcctgtgca agaacatgaa
       61 gcacctgtgg ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgct
      121 tctacaggag tcgggcccag gactggagaa gccttcggag accctgtccc tctcttgcac
      181 tgtctctggt ggctccttca gtggttacta ctggacctgg atccgccagc ccccagggaa
      241 gggactggag tggattgggt ttatcggtgg tggtagtggg agcaccgaat acaacccctc
      301 cctcaaaagt cgagtcacca tttcaagaga cacgtccaag aatcaattct ccctgaggct
      361 gacgtctatg accgccgcgg acacggccgt ctatttctgt gcgagagatg cgggagtggg
      421 agccacaatc ctgtactact atgactactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01007185             427 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20443:10779
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007185
VERSION     KCXD01007185.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 427)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 427)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20443:10779"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    71..425
                     /note="immunoglobulin heavy chain variable region"
     V_region        71..425
     V_segment       71..364
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <356..>394
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65667.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       366..370
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       379..425
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        426..>427
                     /gene="IGHG"
BASE COUNT           90 a           94 c          132 g          111 t
ORIGIN      
        1 acatgggctc accatgaagt ttgggctgag ctgggttttc cttgttgcta ttttaagagg
       61 tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc ctggggggtc
      121 cctgagactc tcctgtgcag cctctggatt caccttcagt atatctggca tgcactgggt
      181 ccgccaggct ccagggaagg ggctggagtg ggtgtcagtt atatcgtctg atggaagtaa
      241 gaaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca attcaaaaaa
      301 catggtatat cttcaaatga acaacctgaa attggaggac acggccgtgt atttctgtgt
      361 gagagatgcc ttcgggggcg gtttggattc ctggggccaa ggggtcgtcg tcaccgtctc
      421 ctcagcc
//
LOCUS       KCXD01007186             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:17638:19840
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007186
VERSION     KCXD01007186.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:17638:19840"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65668.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       447..453
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          119 c          152 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtc cacctggtgg aatctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tctgatgaaa gtaagaaata ctacgccgac tctttgaaag accgattcac catatccaga
      361 gacgactcca ggaacatgct atatcttcaa ctgaacaacc tgaaattgga cgacacggcc
      421 gtgtattact gtgcgagaga tgtgtatggc tgggggcttg actactgggg ccagggagtc
      481 ctagtcaccg tctcctcagc c
//
LOCUS       KCXD01007187             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:9432:13259
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007187
VERSION     KCXD01007187.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:9432:13259"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65669.1"
                     /translation="CAIGPSGSWNDWSFDIW"
     D_segment       418..429
                     /gene="IGHD1-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          139 c          137 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctgtggc ctcagtgaag
      181 gtctcctgca aggtttccgg aagaaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtgggtggga agtgttgatc ctgaatatgg tgaaatgatg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agcagcctga gatctgagga cacggccgtc tattactgtg cgattggccc tagtggcagc
      421 tggaacgact ggtccttcga catttgggga cctggcaccc caatcaccgt ctcctcagcc
//
LOCUS       KCXD01007188             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:15897:8052
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007188
VERSION     KCXD01007188.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:15897:8052"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65670.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       444..449
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          114 c          154 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatccactg ggtccgccag tctccaggga aggggctgga gtgggtggca gtcatatcga
      301 atgatggaaa taataaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccga ggccaaggta tgtcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgtgagagat gcgtatggtt ctggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007189             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:5799:8103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007189
VERSION     KCXD01007189.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:5799:8103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65671.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          123 a          141 c          134 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatgcactg ggtgcgacag
      241 gcccctggag aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aaatccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggaac tgagcagtct gagatctgag gacacggccg tatattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01007190             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:14841:10572
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007190
VERSION     KCXD01007190.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:14841:10572"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..510
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65672.1"
                     /translation="CARVSGHTEGTVEYLDYW"
     D_segment       445..461
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          116 a          116 c          160 g          120 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgagca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtggagc tggtggagtc tggagggggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt agctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcactt atatcgtttg
      301 atggaactaa gcaatactac gcagactctg tgaaggaccg attcaccatt tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacctgaa attgggggac acggccgtgc
      421 attactgtgc gagagttagt gggcatacag agggtacagt tgaatacttg gactactggg
      481 gacagggagc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007191             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18327:13966
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007191
VERSION     KCXD01007191.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18327:13966"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65673.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       423..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          141 c          145 g          104 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagt tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tcctgcaagg ctcctggata catcttcagc atatctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttggtgt aacaacctac
      301 gcacagaact tccaggacag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagtggcggc
      421 ttcgaggatg ataacggtca ctattatacg acactaacat ttcacgagtg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007192             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18965:9869
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007192
VERSION     KCXD01007192.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18965:9869"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65674.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       448..454
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          115 a          115 c          151 g          117 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgctgct
      121 gttttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggaga cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcaccttcag taactatggc
      241 atacactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtct
      301 gatggaagta agacatacta cgcaaactct gtgaaggacc gattcaccat attaagagac
      361 aattccaaga gcatgctcta tcttcaaatg aacaacctga aattggagga cacggccgtc
      421 tattactgtg cgagagacga tatgggaagt ggctttgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007193             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:20813:5217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007193
VERSION     KCXD01007193.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:20813:5217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65675.1"
                     /translation="CARYPRYEDDHGYYSVEIDYW"
     D_segment       403..428
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           95 a          138 c          133 g          115 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcacgagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgt
      181 ctccatcaac attaactact ggagctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt atctatggtg gtgatggcta caccacctcc aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga agtctgtgac
      361 cgccgcggac accgccgtgt attactgtgc gagatatccg cgttacgagg atgatcacgg
      421 ttactattct gtggaaattg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01007194             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:20646:15851
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007194
VERSION     KCXD01007194.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:20646:15851"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..514
     V_segment       139..431
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65676.1"
                     /translation="CCSDYYSGSYYYWGYGLDSW"
     D_segment       434..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..514
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          105 a          126 c          158 g          127 t
ORIGIN      
        1 acatgggggg tctgagacag gagccttagc cctggattcc aagaacttcc actttgggat
       61 cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt
      121 ttaaaaggtg tccagtctga ggtgcagctg gtggagtctg ggggagtctt ggtccagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca gctttggcga tcatggcatg
      241 cactgggtcc gccaggctcc gggaaaggga ctggagtggg tctcatccat tagtaatact
      301 ggtaaagccg tacactacgc tgactccgtg aagggccgat tcaccatctc cagagacaac
      361 gccaagaact cgctgtctct gcaaatgagc agcctgagag ccgaggacac ggccgtatat
      421 tactgttgta gcgattacta tagtggtagt tattactatt ggggctacgg cttggattcc
      481 tggggccaag gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007195             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20892:11139
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007195
VERSION     KCXD01007195.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20892:11139"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65677.1"
                     /translation="CVRDSSGSGFDRW"
     D_segment       438..443
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          110 c          151 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtact tttggcatac
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttata tcgtacgatg
      301 aaaataagaa atactatgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt cacatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agattcaagc ggttcgggat ttgaccgttg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007196             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:3985:17472
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007196
VERSION     KCXD01007196.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:3985:17472"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65678.1"
                     /translation="CAREYCTSSSCAGFLDYW"
     D_segment       413..424
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          109 a          138 c          138 g          105 t
ORIGIN      
        1 acatggggga aacaaccaca tccctcctct aaagaagccc ctgggagcac agctcatcac
       61 catggactgg acctggaggc tcctctttgt ggtggcagca gctgcaggtg tccagtccca
      121 ggtccgcctg gtgcagtccg gggctgaggt gaagaagcct ggggcctcag tgaaggtttc
      181 ctgcggggct tctggattca ccctcgacac ctatggtatc aactgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggagtggt catccccctt attggtatca taaactacgc
      301 aaagaactct cagggcagac tcacaataac cgcgaacacg tccacaaata cagcctattt
      361 ggaactgagc agtctgagat ctgaggacac ggccatctat tactgtgcga gagaatactg
      421 tacttctagt tcttgcgccg ggttccttga ctactggggc cagggagccc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007197             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:21624:4367
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007197
VERSION     KCXD01007197.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:21624:4367"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..374
     V_segment       20..313
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65679.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       315..319
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       328..374
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           79 a           90 c          117 g           90 t
ORIGIN      
        1 acatgggggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
       61 tggggagtcc ctgagactct cctgtgcagc ctctggattc accttcagta cctctggcat
      121 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtgtctgtaa tttcgtctga
      181 tggaagtaag aaatactacg cagactctgt gaaggaccga ttcaccatct ccagagacaa
      241 ctccaagaac atactatatc ttcaaatgaa caacctgaaa ttggaggaca cggccgtgta
      301 tttctgtgtg agagatgcct tcgggggcgg tttggattcc tggggccaag gggtcgtcgt
      361 caccgtctcc tcagcc
//
LOCUS       KCXD01007198             343 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:8857:17766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007198
VERSION     KCXD01007198.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 343)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 343)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:8857:17766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..341
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..341
     V_segment       7..264
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <257..>310
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65680.1"
                     /translation="CTRGIDNYHFSNTDFDYW"
     D_segment       276..283
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       297..341
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        342..>343
                     /gene="IGHG"
BASE COUNT           79 a           86 c           90 g           88 t
ORIGIN      
        1 acatggggta cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt
       61 cagttcctat gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtttc
      121 cggtattaac attggcggtg acacatacta cccagactct gtgaagggtc gattcactat
      181 ctccagagac aatgccaaga actccttgta tcttcaaatg aacagcctga gagttgagga
      241 cactgctgtg tatttttgta caagggggat agataactac cactttagta atacggactt
      301 tgactactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007199             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21830:9020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007199
VERSION     KCXD01007199.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21830:9020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65681.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       432..437
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          112 c          149 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaagaa atactacgca aattctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaaatt ggaggacacg gccgtctatt
      421 attgtgcgag agatgatctt gggaccggtt ttgactactg gggccaggga atcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007200             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11397:12732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007200
VERSION     KCXD01007200.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11397:12732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..492
     V_segment       144..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65682.1"
                     /translation="CARSWGRWSAEYVDFW"
     D_segment       435..440
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..492
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>506
                     /gene="IGHG"
BASE COUNT          107 a          115 c          156 g          128 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctgggattcc caggtgtttt cattcagaga
       61 tcaggactga acacacagga gtcaccatgg agtatttgct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag tgtgtggagc agcaggtgga gtctggggga ggcttggtac
      181 agcctggggc gtccctgaga ctctcctgtg tagcctctga tttcaccttc agtagctatg
      241 acatgcactg ggttcgccag gctccaggga ggggtctgga gtgggtatca ggtattagca
      301 ttggcggtac cacatactac ccagactctt tgaagggtcg attcatcatc tccagagaca
      361 ataccgagaa gtccttgtat cttcaaatga acagcctgag aactgaggac actgctgtat
      421 atttttgtgc aagatcgtgg ggcaggtggt cagcggaata cgtcgacttc tggggccagg
      481 gcgccctggt cagtgtctcg tcagcc
//
LOCUS       KCXD01007201             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:9345:12094
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007201
VERSION     KCXD01007201.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:9345:12094"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65683.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          113 a          121 c          148 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaggtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatgttc aatacctatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgc
      301 atgatggaac taagacatac tacacagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacaacct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggatttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007202             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:18665:13038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007202
VERSION     KCXD01007202.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:18665:13038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..486
     V_segment       135..424
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65684.1"
                     /translation="CAGGAYANLDYW"
     D_segment       435..439
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..486
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          106 a          124 c          150 g          108 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcactg
       61 aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg caaatggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagtagatac tggatgaact
      241 gggtccgcca ggctccagga aaggggctgg agtgggtctc agctcttaat tatgatgggg
      301 atagtacata ctacgcagac tccgtgaagg gccgattcac catctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgcacagcc tgagagaaga tgacacggcc gtttatttct
      421 gtgcgggcgg ggcgtacgct aacctcgact actggggcca gggagtcctg gtcaccgtct
      481 cctcagcc
//
LOCUS       KCXD01007203             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:5160:13070
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007203
VERSION     KCXD01007203.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:5160:13070"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..309
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..309
     V_segment       5..251
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <246..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65685.1"
                     /translation="CTRQQSNHDVW"
     D_segment       261..266
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       269..309
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        310..>311
                     /gene="IGHG"
BASE COUNT           65 a           98 c           82 g           66 t
ORIGIN      
        1 acatggggac cctgtccctc acctgcgctg tctctggtgg ctccatcagt ggttatggct
       61 ggagctggat ccgccaggcc ccagggaagg gactggagtg gattgcaact atctatggta
      121 gtagtggtaa cacctactac aacccctccc tcaggagtcg agtcaccatt tctaaagaca
      181 cgtccaacaa ccacttctcc ctgaggctga actctgtgac cgccgcggac acggccgtgt
      241 attactgtac gcgccaacaa agtaaccacg atgtctgggg cccgggagtc ctggtcaccg
      301 tctcctcagc c
//
LOCUS       KCXD01007204             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13676:14065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007204
VERSION     KCXD01007204.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13676:14065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65686.1"
                     /translation="CARGTVTLGTLDSW"
     D_segment       400..408
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           92 a          132 c          136 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga catcctgtgc aagaacatga agtacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc aactgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcaactgca ctgtctctgg
      181 tggctccatc agaggttact actggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg ggtgtcggtg gtattactgg gatttcggac tacagcccct ccctcaaaag
      301 tcgagtcacc atttcaagag acacgtccaa gaaccagttg tccctgaatc tgaccgttgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagaggt acagtaacct tgggaaccct
      421 tgactcctgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007205             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15398:5871
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007205
VERSION     KCXD01007205.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15398:5871"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65687.1"
                     /translation="CARWSAANFDLW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           90 a          134 c          134 g           99 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaggc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggggg
      181 ctccatcaac agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtatctatg atagtagtgg aaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaaaag acacgtccaa gaaccagttc tccctgaatc tgaggtctat
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg tcggcagcca actttgacct
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007206             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5883:15986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007206
VERSION     KCXD01007206.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5883:15986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65688.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          138 c          128 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ttcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgcggc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattggatat atctctggtg cctatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007207             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19521:15396
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007207
VERSION     KCXD01007207.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19521:15396"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..433
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65689.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       442..453
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          116 a          109 c          155 g          116 t
ORIGIN      
        1 acatgggggg gggagaggag cccagccctg gaagtccaca gtgttccatt cggtgatcag
       61 cacagaacac agaggactca ccatgaagtt tgggctgagc tgggttttcc ttgttgcgat
      121 tttaagaggt gtccagtgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
      181 tggggggtcc ctgagactct cctgtgcagc ttctggattc accttcagta gttatggcat
      241 gcactgggtc cgcctggctc cggggaaggg gctggagtgg gtggcagtta catcgtctga
      301 tgaaagtaag aaatactacg gagactctgt gaaggaccga ttcaccatct ccagagacaa
      361 ttccaagaac atactatatc ttcaaatgaa caacctgaaa ttgaaggaca cggccgtata
      421 ctactgtggg agagatgata atggggtgat tatcgactac tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01007208             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11299:7382
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007208
VERSION     KCXD01007208.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11299:7382"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..482
     V_segment       113..406
                     /gene="IGHV7-86"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65690.1"
                     /translation="CARSLGWHDYNDVALDFW"
     D_segment       421..433
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          113 a          137 c          138 g           96 t
ORIGIN      
        1 acatggggaa caacaacacc cctccacaga agcccctgga tcacagctcc ttgccatgga
       61 ctggacctgg aggatcctct tcttggtggc agcagcaaca ggtgcccact cccaggtgca
      121 gctggtgcag tcgggggctg aggtgaagca gccggggaca tcagtgaagg tctcctgcaa
      181 ggcttctggc tacaccttca ctagctatgg tatgaactgg gtgcgacagg cccagggaca
      241 acggcttgag tggatgggat ggctcaacac cgacactggg aacccaacgt atgcccaggg
      301 cttcaaagaa cgatttacat tctccatgga cacctctatg accacggcat atctgcagat
      361 cagcagccta aagactgagg acacggccgt atactactgt gcaagaagtt tgggctggca
      421 tgattataat gacgtcgccc ttgacttctg gggccaggga gtcctggtcg ccgtctcctc
      481 agcc
//
LOCUS       KCXD01007209             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15756:7754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007209
VERSION     KCXD01007209.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15756:7754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65691.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          126 c          153 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg ttcagttaat ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtctta acgctggtgg
      301 ggataccacc tactatgcag actccgtgaa gggcagatcc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007210             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:18807:6215
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007210
VERSION     KCXD01007210.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:18807:6215"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65692.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          115 c          155 g          123 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaaa taacatatac tacgcagcct ctgtgaagga ccgattcgcc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaatttgag gacacggccg
      421 tgtattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007211             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9087:16921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007211
VERSION     KCXD01007211.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9087:16921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..489
     V_segment       135..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65693.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       432..444
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          112 c          145 g          120 t
ORIGIN      
        1 acatggggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg atcagcacag
       61 aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt gctattttaa
      121 gaggtgtcca gtgtgaggtg cagttggtgg agtctggagg aggcttggtt cagcctgggg
      181 ggtccctgag actctcctgt gcagcctctg gattcacctt cagaaactat ggcatgcact
      241 gggtccgcca ggccccaggg aaggggctgg attgggtggc agttatgtcg tttgatgaaa
      301 atgtgaaatt ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      361 agaatatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc ctgtattact
      421 gtgcgagagg ggaatacagt aactctattg acttctgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01007212             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11217:9944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007212
VERSION     KCXD01007212.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11217:9944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65694.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       431..437
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          116 a          111 c          142 g          121 t
ORIGIN      
        1 acatgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcaacacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccgg tgtgaggtgc aactggtgga gtctggagga ggcttggttc aacctggggg
      181 gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtaagtttg gcatacactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt ctgatggaag
      301 taacaaatac tacgcaaact ctgtgaagag ccgattcacc atctccagag acaattccaa
      361 gaacatactt tatcttcaaa tgaacaactt gaaattggag gacacggccg tctattactg
      421 tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007213             300 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:8583:7027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007213
VERSION     KCXD01007213.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 300)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 300)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:8583:7027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..298
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..298
     V_segment       8..236
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <229..>267
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65695.1"
                     /translation="CASGRRQLDFDYW"
     D_segment       243..254
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..298
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        299..>300
                     /gene="IGHG"
BASE COUNT           61 a           89 c           86 g           64 t
ORIGIN      
        1 acatggggcg ctgtctctgg tggctctatc aacatttact actggaattg gatccgccag
       61 gccccaggga agggactgga ctggattgga catatctatg gtagcggtgg tagcaccaac
      121 tacaacccct ccctcaagag tcgagtcacc ctgtcagtgg acacgtccaa gaaccacttc
      181 tccctgaacc tgaggtctgt gaccgccgcg gacacggccg tatattactg tgcgagcggt
      241 cggcggcagc tggactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007214             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:19231:4166
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007214
VERSION     KCXD01007214.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:19231:4166"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..408
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65696.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       413..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          119 a          140 c          132 g           96 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag gtggtgcagt ctggggctga ggtgaaggag cctggggcct cagcgaaggt
      181 ctcctgcaag atttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ctatatggtg aaatgaaaca
      301 cacagagttc catgccagat tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagttgagc agcctaagat ctgaggacac ggccctgtat tattgtgcag tcgggtatag
      421 cggccgatgg aacaactggt acttcgatct ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007215             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20969:14223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007215
VERSION     KCXD01007215.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20969:14223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65697.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       449..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          113 c          153 g          122 t
ORIGIN      
        1 acatggggga gctctgggat aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggagg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtttctat
      241 ggcatacact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatttcg
      301 aatgatgaaa ctaagaaata ctacgcagac tctgtgaagg accgattcac catttccaga
      361 gacaattcca agaacatgct atttcttcaa atggacaacc tgaaattgga ggacacggcc
      421 gtctattatt gtgtgagaga tgatttaggc agcggcttag ggtcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007216             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10265:9377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007216
VERSION     KCXD01007216.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10265:9377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65698.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       440..444
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc atctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcatgcactg ggtccgccag gctccaggaa aggggctgga ctgggtggca gttatgtcgt
      301 ctgatagaaa taacaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagagat gtctttggcg gggggcttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007217             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23208:5518
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007217
VERSION     KCXD01007217.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23208:5518"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65699.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           80 a          137 c          143 g          100 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg gactggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa tccctactac aacccctccc tccagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga ccagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007218             305 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:6080:9465
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007218
VERSION     KCXD01007218.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 305)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 305)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:6080:9465"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..303
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..303
     V_segment       8..242
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <234..>272
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65700.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       246..261
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       269..303
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        304..>305
                     /gene="IGHG"
BASE COUNT           72 a           91 c           77 g           65 t
ORIGIN      
        1 acatgggctc ctgtaagact tctggataca gctttaccac caactggatc agttgggtgc
       61 gccagacgcc cggaaaaggc ctggaatgga tggggaccat ctatcctgct gattctgagg
      121 ccaaatacaa cccgtccttc caaggccacg tcactatctc agccgacaag tccatcagta
      181 ccacctacct gcagtggagc agcctgaagg cctcggacac cgccacgtat ttctgtgcga
      241 aaacctacta tagtggtagt ttggaaatct ggggccaggg agtcctggtc accgtctcct
      301 cagcc
//
LOCUS       KCXD01007219             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15057:14964
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007219
VERSION     KCXD01007219.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15057:14964"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..454
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65701.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       390..405
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       408..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           88 a          140 c          132 g           96 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 agcagtacct actggagctg gatccgccag cccccaggga agggactgga gtggattgga
      241 cgtatctctg gtggtggtgg gaacaccgac tacaacccct ccctcaagag tcgagtcacc
      301 atttcaagag acacgtccag gaaccagttc tccctgcagc tgaattatgt aaccgccgcg
      361 gacacggccg tgtattactg tgccagaact agcggtggct ggtcccccta ctttgactat
      421 tggggccggg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007220             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:10400:8713
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007220
VERSION     KCXD01007220.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:10400:8713"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65702.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       442..450
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          111 c          152 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgcgattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 aggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtttc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgaatgatg
      301 aaactaagaa atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat gctttttctt caaatggaca acctgaaatt ggaggacacg gccgtctatt
      421 attgtgtgag agatgattta ggcagcggct tagggtcctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007221             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:18555:2274
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007221
VERSION     KCXD01007221.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:18555:2274"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..488
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65703.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       416..422
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          121 a          141 c          128 g          100 t
ORIGIN      
        1 acatggggag caacacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaagtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gaaccacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagttttaat cctatatatg gtgaaatttt
      301 acacacagag aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgatttctga ggacacggcc gtgtattact gtgcggcagc
      421 tgatagtggt tacccatttt actacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007222             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:5583:13988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007222
VERSION     KCXD01007222.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:5583:13988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65704.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       417..429
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          110 a          143 c          139 g           91 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tctttctggt gcagtctggg gctgaggtga agcagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacacc ctcaccgaag tgtccactca ctgggtgcga
      241 caggcccccg gaaaagggct tgagtgggtg ggaagtgttg atcctgcata tggtgaaatg
      301 aagttccagg gcagagtcac catgaccgag gacacgtcca cagacacagc ctacatggaa
      361 ttgagcagcc taagatctga ggacacggcc gtgtattact gtgcgattgg acctaccggc
      421 aggtggaacg gctggtcctt cgatatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01007223             291 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:13712:9265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007223
VERSION     KCXD01007223.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 291)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 291)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:13712:9265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..289
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..289
     V_segment       8..211
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <205..>258
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65705.1"
                     /translation="CATAGYSSSESFYGLDSW"
     D_segment       220..231
                     /gene="IGHD6-39"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       240..289
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        290..>291
                     /gene="IGHG"
BASE COUNT           65 a           82 c           83 g           61 t
ORIGIN      
        1 acatggggca gtaactactg gagctggatc cgccagtccc cagggaaggg actggagtgg
       61 attggacgta tctctggtag tggtgggaac accgtctaca acccctcttt caagagtcga
      121 gtcaccattt caacagacac gtccaagaac cagatctccc tgaaagtgac ctctgtgacc
      181 gccgcggaca cggccgtgta ttattgtgcg acagccggct atagcagcag cgaaagcttc
      241 tacggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01007224             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:14559:10857
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007224
VERSION     KCXD01007224.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:14559:10857"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..330
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..330
     V_segment       8..260
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <252..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65706.1"
                     /translation="CARRDSWNNGGSLDYW"
     D_segment       265..278
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..330
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        331..>332
                     /gene="IGHG"
BASE COUNT           67 a           92 c           99 g           74 t
ORIGIN      
        1 acatggggga gaccctgtcc ctcacttgcg ttgtctctgg ccactccatc agcagtggct
       61 accactgggg ctggatccgt cagcccccag ggaagggact ggactatatt ggctatatca
      121 gtggtagtag tgggagcacc tactacaagc cctccctcat gagtcgagtc atcatttcaa
      181 gagacacgtc ccggaatgag ttctccctga ggctgaggtc tgtgactgtc gcggacacgg
      241 ccgtgtatta ttgtgcgaga cgagatagct ggaacaacgg ggggagcctt gactactggg
      301 gccagggatt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007225             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14373:3986
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007225
VERSION     KCXD01007225.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14373:3986"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65707.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          109 c          153 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtagt tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 taagtaagaa atactacgca gacgctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgggag agatgataat ggggtgctta tcgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007226             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:19601:2453
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007226
VERSION     KCXD01007226.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:19601:2453"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65708.1"
                     /translation="CAVGYSGRWNNWYFDLW"
     D_segment       415..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          118 a          141 c          133 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaagg agcctggggc ctcagcgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccatgcactg ggtgcgacag
      241 tcccctggaa aagggcttga gtggatggga agtgttgatc ctctatatgg tgaaatgaaa
      301 cacacagagt tccatgccag attcaccatg accgaggaca cgtctacaga cacagcctac
      361 atggagttga gcagcctaag atctgaggac acggccctgt attattgtgc agtcgggtat
      421 agcggccgat ggaacaactg gtacttcgat ctctggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01007227             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6958:5606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007227
VERSION     KCXD01007227.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6958:5606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..488
     V_segment       137..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65709.1"
                     /translation="CAGGAYANLDYW"
     D_segment       437..441
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          106 a          124 c          152 g          108 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcaaatggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagat actggatgaa
      241 ctgggtccgc caggctccag gaaaggggct ggagtgggtc tcagctctta attatgatgg
      301 ggatagtaca tactacgcag actccgtgaa gggccgattc accatctcca gagacaactc
      361 aaagaacacg ctctccctgc aaatgcacag cctgagagaa gatgacacgg ccgtttattt
      421 ctgtgcgggc ggggcgtacg ctaacctcga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007228             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11654:11484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007228
VERSION     KCXD01007228.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11654:11484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..484
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65710.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       409..416
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          110 a          135 c          138 g          103 t
ORIGIN      
        1 acatggggga accacatccc tcctctaaag aagcccctgg gagcacagct catcaccatg
       61 gactggacct ggaggctcct ctttgtggtg gcagcagctg caggtgtcca gtcccaggtc
      121 cgcctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgag gatttcctgc
      181 ggggcttctg gattcaccct cgacacctat ggtatcaact gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agtgatcatc ccccttattg gtatcataaa ctacgaaaag
      301 aactctcagg gcagagtcac aataaccgcg aacacgtcca caaatacagc ctatatggaa
      361 ctgagcagtc tgagatctga ggacacggcc atctattact gtgcgagaga atactgcact
      421 tctagtactt gcgccgggtt ccttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01007229             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:12561:6049
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007229
VERSION     KCXD01007229.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:12561:6049"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65711.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          120 a          141 c          143 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccaa ctggtgcagt ctggggctga aatgaagaag cctggggcct cagttagggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgtcgatcct gaacaaggtg aaataataca
      301 cgcagagaaa ttccagggca gagtcaccat gaccgaggac acgtctacag acacagcctt
      361 catggagttg agcagcctga gatctgagga cacggccgtg tatttctgtg cgaaaggggg
      421 gttcggaacc agcgtctggt ccaacctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007230             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:12947:3469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007230
VERSION     KCXD01007230.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:12947:3469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..455
     V_segment       102..392
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65712.1"
                     /translation="CATGKRQLDLDYW"
     D_segment       399..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           86 a          137 c          133 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc gagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtga
      181 ctctatcagc agttacttct ggaactggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggttt ctctatggta gtgatagtac ctccaactac aacccctccc tcaagagccg
      301 agtcaccctg tcagtggaca cgtccaagaa ccaagtctcc ctgatgctga gctctgtgac
      361 cgccgcggac acggccgtct attactgtgc gaccgggaag cggcagctgg atcttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007231             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:15300:11813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007231
VERSION     KCXD01007231.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:15300:11813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65713.1"
                     /translation="CARVGEGTGGAEDFDFW"
     D_segment       442..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          111 a          114 c          160 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagtct ccggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggagtgggt ggcactgata tcgtatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tttgtgcgag agttggagag ggtactggtg gtgcggagga ctttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007232             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:21495:13386
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007232
VERSION     KCXD01007232.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:21495:13386"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65714.1"
                     /translation="CARGLPTVFGMVITELW"
     D_segment       410..425
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..467
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           87 a          140 c          134 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc gcttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggcat ataagtgtca gtcttgggag caccgcctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagttga actctgtgac
      361 cgccgcggac acggccgtgt ttttttgtgc gagaggactt cctacagttt ttggaatggt
      421 tattacggaa ctctggggcc cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007233             382 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:10280:7133
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007233
VERSION     KCXD01007233.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 382)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 382)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:10280:7133"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..380
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..380
     V_segment       8..293
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <287..>349
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65715.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       316..323
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       329..380
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        381..>382
                     /gene="IGHG"
BASE COUNT           90 a           96 c          112 g           84 t
ORIGIN      
        1 acatgggcag ctggtgcagt ctggggctga ggttaagaag cctggggcct cagtgagggt
       61 ctcctgccag gtttccggat acaccttcac cgaattatcc atgcactggg tgcgacaggc
      121 ccctggaaaa gggcttgagt ggatgggatg tgttgatcct gtaaatggtg aaataataca
      181 cgcagacaac ttccagggca gagtcaccat gaccgaagac acgtctatag acacagccta
      241 catggaactg agcagcctga gatctgagga tacggccgta tattactgtg cgacccacgg
      301 aggctatagt gacatctgga actccctgta ctacggtttg gattcctggg gccaaggggt
      361 cttcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007234             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:27601:7793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007234
VERSION     KCXD01007234.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:27601:7793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65716.1"
                     /translation="CARYDADSADYYFDLW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           92 a          141 c          129 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa accttcggag accctgtccc tcacctgcgc tgtctctggc
      181 gcctccatca gcaatagctt ctggaactgg atccgccagc cccccgggaa ggggctggag
      241 tggattgggt cgatctatgg gagtactggg agcacaagct acaacccctc cctcaacagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgtcgcgg acaccgccgt gtattattgt gcgagatatg atgctgatag tgccgattac
      421 tactttgacc tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007235             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18623:8151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007235
VERSION     KCXD01007235.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18623:8151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..472
     V_segment       118..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65717.1"
                     /translation="CAIGPSGIWNGWSFDIW"
     D_segment       405..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           98 a          138 c          140 g           98 t
ORIGIN      
        1 acatgggaca caacagccac ttccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcgtcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccttctgg tgcagtctgg ggctgaggtg atgcagcctg gggcctcagt gaaggtctcc
      181 tgcaaggttt ccggatacac cttcaccgaa ttgtccatgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtgggt gggaagtgtt gatcctgtat atggtgaaat ggtgttccag
      301 ggcggggtca ccatgaccga ggacacgtct acagacacag cctacttgga gctgaacagc
      361 ctgaggtctg aagacacggc cgtgtattac tgtgcgattg gccctagcgg catctggaac
      421 ggctggtcct tcgatatctg gggccctggc accccaatca ccatctcctc agcc
//
LOCUS       KCXD01007236             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:25139:9724
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007236
VERSION     KCXD01007236.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:25139:9724"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..490
     V_segment       121..414
                     /gene="IGHV1-124"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65718.1"
                     /translation="CTRAGIQPQPDEGDFDYW"
     D_segment       417..425
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..490
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          122 a          141 c          135 g           94 t
ORIGIN      
        1 acatggggac tcaacaactg catccaacct caagagaagc ccctgagagc acagtttctc
       61 accatggact tgacctggaa gatcctcctc ttggtgacag cagccacagg tgcccactcc
      121 caggtgcagc tggtgcagtc tggggctgag attaagcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg cttctggata tttcttccct aactacgaca tacactgggt gagacaggcc
      241 ccgggacaag gccttgagtg gataggactg atctcccctt acaatggtca cagaggctac
      301 gcacagaact tccaggacag agtcaccata actacggaca cgtccacggg catggcctac
      361 atggagctga gcagcctgag atctgaggac acagccatat atttctgtac gagagcgggg
      421 atacaaccac agccagacga gggggacttt gactactggg gccagggagt cctggtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01007237             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9081:5147
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007237
VERSION     KCXD01007237.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9081:5147"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65719.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           91 a          133 c          137 g           98 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgag gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcga tgtctctggg
      181 ggctccatca gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtgtatcta cgatagtagt ggaaacacct actacaaccc ctccctcaag
      301 agtcgagtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gctgaggtct
      361 atgaccgccg cggacgcggc cgtgtattac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007238             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16742:7641
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007238
VERSION     KCXD01007238.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16742:7641"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..488
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65720.1"
                     /translation="CARHRTSDYYSGSYPNPFRSFDFW"
     D_segment       408..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           95 a          150 c          138 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggagaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtac atcaatggtg ctagtgggag caccacctac aacccgtccc tccagagtcg
      301 agtcaccatt tccattgaca cgtccaagaa ccagttctcc ctgaggctga gctctgtgac
      361 cgccgcggac acggccatgt attactgtgc gagacatagg acgtcggatt actatagtgg
      421 cagttaccca aaccccttcc gctcctttga cttctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007239             278 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11305:7447
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007239
VERSION     KCXD01007239.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 278)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 278)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11305:7447"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..276
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..276
     V_segment       5..191
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <183..>245
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65721.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       200..207
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       231..276
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        277..>278
                     /gene="IGHG"
BASE COUNT           62 a           65 c           93 g           58 t
ORIGIN      
        1 acatggggcg acaggcccct ggaaaagggc ttgagtggat gggaggtgtt gaccctggaa
       61 atggtgaaat aatacacgca gatagtttcc agggcagagt caccatgacc gaggacacgt
      121 ctacagacac agcctacatg gagctgagcg gcctgagatc tgaggacacg gccgtgtatt
      181 actgtgcgag aggggggttc ggtagcagtg tctggtccaa tctcgtttat ggtttggatt
      241 cctggggcca aggggtcgcc gtcaccgtct cctcagcc
//
LOCUS       KCXD01007240             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:20113:16334
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007240
VERSION     KCXD01007240.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:20113:16334"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    60..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        60..438
     V_segment       60..351
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <345..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65722.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       374..380
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       389..438
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           98 a          116 c          134 g           92 t
ORIGIN      
        1 acatgggctg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
       61 aggtccaact ggtgcagtct ggggctgaaa tgaagaagcc tggggcctca gttagggtct
      121 cctgcaaggt ttccggaaac accttcaccg aattatccat gcactggctg cgacaggccc
      181 ctggaaaagg gcttgagtgg atgggatgtg tcgatcctgc acaaggtgaa ataatacacg
      241 cagagaaatt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagccttca
      301 tggagttgag cagcctgaga tctgaggaca cggccgtgta tttctgtgcg aaaggggggt
      361 tcggaaccag cgtctggtcc aacctcttct acggtttgga ttcctggggc caaggggtcg
      421 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007241             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:11454:13783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007241
VERSION     KCXD01007241.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:11454:13783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..473
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65723.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       401..414
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..473
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           97 a          136 c          137 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagt tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc ggttactatt ggagctggat ccgtcagccc ccagggaagg ggctggagtg
      241 gattgggtat atcagtgcta gtagtgggag caccgactac aacccctccc tcaagagacg
      301 agtcaccatg tcaacagaca cgtccaataa ccaattctcc ctgaagctga cctctttgac
      361 ggccgcggac acggccgtgt attactgtgc gagagagaaa tactatagtg gtagctataa
      421 gcacaactgg ttcgatgtct ggggcccggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007242             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:14083:3828
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007242
VERSION     KCXD01007242.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:14083:3828"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..482
     V_segment       119..407
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65724.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       415..423
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..482
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT          117 a          140 c          132 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccccccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca actacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggccgaagt gaagaagcct ggggcctcag tgagggtctc
      181 ctgcaaggtt tccggacaca cctacaccga agtatccatt cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaggtgt tgctcctata tatggtgaaa tactaaacac
      301 agacaagttc cagggcagag tcaccatgac cgaggacacg tctgcagaca cagcctacat
      361 ggagttgagc agcctgagat ctgaggacac ggccgtatat tactgtgtgg cggctgatag
      421 tggttaccct ttttactact tcgatatctg gggccctggc accccaatca gcatctcctc
      481 agcc
//
LOCUS       KCXD01007243             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:15966:16223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007243
VERSION     KCXD01007243.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:15966:16223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65725.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       446..454
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          112 a          111 c          157 g          118 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctgggggagg cttggttcag
      181 cctggggggt ccctgagact ctcctgtgca gcctctggat tcagcttcag tatctttggc
      241 atgcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatgtcgaat
      301 gatggaagta agaaatacta cacagactct gtgaaggacc gattcaccat ctccagagac
      361 aattccaaga aaatgctata tcttcaaatg aacaacctga aattggagga cacggccgtg
      421 tattattgcg cgagagacga ttttggcagc ggcttagggt actggggcca gggagccctg
      481 gtgaccgtct cttcagcc
//
LOCUS       KCXD01007244             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:18468:19027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007244
VERSION     KCXD01007244.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:18468:19027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65726.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       414..420
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          136 c          141 g           99 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagt cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtacagtctg gggctgaagt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaagtt tccggataca ccttcaccga tttatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaggtgt tgatactgta tctgatggaa tgatatacgc
      301 agaaaacttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtttat tactgtgcga gaggtgtgac
      421 agcagacgtc ttcggtttcc tcgggcttga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007245             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:6449:11503
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007245
VERSION     KCXD01007245.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:6449:11503"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65727.1"
                     /translation="CAREERFGYSFDFW"
     D_segment       451..459
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          116 a          119 c          147 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc actacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatgaaat taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagggag gagagatttg gctacagttt tgacttctgg ggccagggaa
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007246             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:9760:12817
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007246
VERSION     KCXD01007246.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:9760:12817"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65728.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       435..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          120 a          142 c          141 g           98 t
ORIGIN      
        1 acatggggtc acacaacaac cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctacagg cgcccactct
      121 gaggtccaac tggtgcagtc tggggctgaa atgaagaagc ctgggacctc agttagggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattatcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg gatgggatgt gtcgatcctg cacaaggtga aataatacac
      301 gcagagaaat tccagggcag agtcaccatg accgaggaca cgtctacaga cacagccttc
      361 atggagttga gcagcctgag atctgaggac acggccgtat atttctgtgc gaaagggggg
      421 ttcggaacca gcgtctggtc caacctcttc tacggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01007247             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16096:4462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007247
VERSION     KCXD01007247.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16096:4462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..430
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65729.1"
                     /translation="CTRIGVGSLATAGEYFDYW"
     D_segment       450..463
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          106 a          130 c          156 g          122 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg aggtgcagct gatggagtct gggggaggct tggtccagcc
      181 tggggggtcc ctgagactct cctgtgcagc ctctggattc acctttggtg attatggcat
      241 gcactgggtc cgccaggctc cgggaaaggg actggagtgg gtctcatcca ttaggaacac
      301 tggtacaccc gtatactacg ctgactccgt gaagggccga ttcaccatct ccagagacaa
      361 cgccaagaac tcactgtctc tgcaaatgag tagcctgaga gccgaggaca cggccgtgta
      421 ttactgtact cggattggcg tcggatctct agcaacggct ggtgaatact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007248             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13038:5618
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007248
VERSION     KCXD01007248.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13038:5618"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65730.1"
                     /translation="CARDDLGTGFDYW"
     D_segment       437..442
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          116 c          147 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca attggtggag tctggaggag gcttggttca
      181 acctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatttcgtc
      301 tgatggaagt aacaaatact acacaaactc tgtgaagagc cgattcaccg tctccagaga
      361 caattcccag aacatacttt atcttcaaat gaacaacttg aaattggagg acacggccgt
      421 ctattactgt gcgagagatg atcttgggac cggttttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007249             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:23788:4021
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007249
VERSION     KCXD01007249.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:23788:4021"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65731.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          120 c          153 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggggg aggcttggtt
      181 cgccctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtcgcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttttgtcg
      301 tctgatggag gttacaaata ccacgcagac tctaagaagg accgattcac catctccaga
      361 gacaattcca agaacatcct atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgcgagagg ggaatacagt aactctattg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007250             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:14516:20302
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007250
VERSION     KCXD01007250.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:14516:20302"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65732.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       447..456
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          110 a          120 c          150 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccact gtgaggtgca actggtggag tctggaggag gcttggttcg
      181 gcctgggggg tccctgagac tctcctgtgg agcctctgga ttcaccttca gtaattttgg
      241 catccactgg gtccgccagg ctccagggaa gggcctggag tgggtggcag ttatatcgtc
      301 tgatgaaagt aagaaatact atgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatactat atcttcaaat gaacaacctg aagttggacg acacggccgt
      421 ctattactgt gcgagagacg catttggcag cggctgtgac tactggggcc ggggcgtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007251             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:26070:17275
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007251
VERSION     KCXD01007251.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:26070:17275"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65733.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       440..447
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          125 a          143 c          141 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagcc acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaagttaa gaagcctggg gcctcagtga
      181 tggtctcctg ccaggtttcc ggatacaccg tcaccgaaat atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaagtgttgc tcctgaaaaa aatgagttaa
      301 tacacgcaga caagttccag gacagagtca gcatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagtggc ctgacatttg aggacacggc cgtgtattac tgtgcgaccc
      421 acggaggtta tagcgacatc tggaactccc tatataacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007252             285 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:10577:19823
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007252
VERSION     KCXD01007252.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 285)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 285)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:10577:19823"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..283
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..283
     V_segment       8..208
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <202..>252
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65734.1"
                     /translation="CAIGPSGRWNAWSFDIW"
     D_segment       216..231
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       234..283
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        284..>285
                     /gene="IGHG"
BASE COUNT           65 a           80 c           84 g           56 t
ORIGIN      
        1 acatgggaca gcttcaccga attgtccatg cactgggtgc gacaggcccc tggaagaggc
       61 cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgacgttcca gggcagagtc
      121 accatgaccg aggacacgtc tacagacaca gcctacatgg aactgagcag cctgagatct
      181 gaggacacgg ccgtatatta ctgtgcgatc ggccctagcg gcaggtggaa cgcctggtcc
      241 ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01007253             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14618:3363
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007253
VERSION     KCXD01007253.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:14618:3363"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65735.1"
                     /translation="CARVSGHTEGTVEYFDYW"
     D_segment       448..464
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          116 a          119 c          158 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagggttc cactcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggcc cttatatcgt
      301 ttgatggaac taagcaatac tacgcagact ctgtgaagga ccgattcacc atttcaagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaagaacct gaaattgggg gacacggccg
      421 tgcattactg tgcgagagtt agtggtcata cagagggtac agttgaatac tttgactact
      481 ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007254             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16179:13006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007254
VERSION     KCXD01007254.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16179:13006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65736.1"
                     /translation="CARWSAANFDSW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           85 a          134 c          137 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatccgc agtggttatg gctggagctg gatccgccag tccccaggga aggggctgga
      241 gtggattgga tgtgtctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaatgg acacgtccaa gaaccagttc tccctggagc tgaggtctat
      361 gaccgccgcg gacacggccg tgtatcactg tgcgagatgg tcggcagcca actttgactc
      421 ctggggtcag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007255             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:25835:9086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007255
VERSION     KCXD01007255.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:25835:9086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65737.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       434..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          107 a          116 c          153 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgtttctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggagtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag ctctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ccggagtggg tgtctgtaat ttcgtctgat
      301 ggaagtaaga aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaac
      361 tccaagaaca tactatatct tcaaatgaac aacctgaaat tggaggacac ggccgtgtat
      421 ttctgtgtga gagatgcctt cgggggcggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007256             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18263:19203
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007256
VERSION     KCXD01007256.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18263:19203"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..395
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65738.1"
                     /translation="CAKQYSGSYYYSHFDFW"
     D_segment       401..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           92 a          141 c          131 g          108 t
ORIGIN      
        1 acatgggggt ctgagagtca gggacctcct gtgcaagaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcaggtc ccagatgggt cctgtcccag ccgcagctgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcgcctgcg ttgtctctgg
      181 tggctccatc agcgattact cctggagctg gatccgccag cccccaggga agggactgga
      241 gtggattggg aatattgatg ttcatcttgc gggccccaac tacaacccct ccctcaagag
      301 tcgagtcgcc atttcaaaag acacgtccaa gaatcagttc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tatatttctg tgcgaaacaa tatagtggta gttattacta
      421 ctcccacttt gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007257             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:24247:17387
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007257
VERSION     KCXD01007257.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:24247:17387"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..504
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65739.1"
                     /translation="CARVGEDTGGAEDLDFW"
     D_segment       443..449
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..504
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          117 c          157 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctcttt
      121 taagaggtgt ccagtgtgag gtacaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ccggattcac cttcagtagt tttggcatgc
      241 actgggtccg ccaggctcca gggaagggac tggactgggt ggcactgata tcgtatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt caccctctcc agagacaatt
      361 ccgagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tttgtgcgag agttggagag gatactggtg gtgcggagga ccttgacttc tggggccagg
      481 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007258             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:22617:10039
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007258
VERSION     KCXD01007258.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:22617:10039"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65740.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           95 a          137 c          128 g          109 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggtcca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggaactg gatccgccag cccccaggca agggactgga
      241 gtggattgga tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcgacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattactg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac ttctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007259             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:25338:14243
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007259
VERSION     KCXD01007259.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:25338:14243"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65741.1"
                     /translation="CARNRFMGVRPLAYW"
     D_segment       400..404
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           96 a          136 c          128 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtccagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtga
      181 ctccatcagt ggttactact ggaactggat ccgccaacca ccagggaagg gactggagtg
      241 gattgggtat atcgctggta gtagtgggag cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccatct attactgtgc gagaaataga tttatgggtg taaggcctct
      421 tgcctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007260             356 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:26781:14330
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007260
VERSION     KCXD01007260.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 356)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 356)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:26781:14330"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..354
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..354
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>323
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65742.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       288..295
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       310..354
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        355..>356
                     /gene="IGHG"
BASE COUNT           73 a          105 c           96 g           82 t
ORIGIN      
        1 tgctggagtc gggcccggga ctggtgaagc cttcggagac cctgtccctc acctgcgctg
       61 tctctggtga ctccatcagc actagttact ggaactggat ccgccagccc ccagggaagg
      121 gactggagtg gattgggtat atctctggtg cttatgggag caccagctac aacccctccc
      181 tcaagagtcg agtcaccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctga
      241 gttctgtgac cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca
      301 ttaactacca ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007261             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18655:15071
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007261
VERSION     KCXD01007261.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18655:15071"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65743.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          130 c          136 g          107 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatttatg ggagtgatag tagtaccaaa tacaacccct ccttcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccggtgt tccctgaagc tgaactctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007262             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15868:8658
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007262
VERSION     KCXD01007262.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15868:8658"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65744.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       438..443
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..493
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          108 a          112 c          155 g          120 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagagcaca gaggactcac catgaagttt gggctgagct gggttttcct tgttggtatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtat ctctggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggagtggg tggcagttaa atcgtttgat
      301 ggaactaaga tatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctatatct tcaaatgaac aacctgaaat tggaggacac ggccgtttat
      421 tactgtgtga gagatgccta cgggagtggt ttggattcct ggggccaagg ggtcgtcgtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007263             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:8317:6792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007263
VERSION     KCXD01007263.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:8317:6792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..461
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65745.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       405..413
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>465
                     /gene="IGHG"
BASE COUNT          108 a          100 c          147 g          110 t
ORIGIN      
        1 acatggggag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgttgctatt ttaagaggtg tccagtgtga ggtgcagctg
      121 gtggagtctg gaggaggctt ggttcagccg ggggggtccc tgagactctc ctgtgcagcc
      181 tctggattca ccttcagtaa ctatggcatg cactgggtcc gccaggctcc agggaagggg
      241 ctggagtggg tggcagttat gtcgaatgat ggaagtaaga agtactacgg agactctgtg
      301 aaggaccgat tcaccatatc cagagacaat tccaagaaca ggctatatct tcaaatgaac
      361 aacctgaaat tggaggacac ggcagtgtat tactgtgcga gagatgatag tggggtgatc
      421 atcgactact ggggccaggg agtcctggtc accgtctcct ccgcc
//
LOCUS       KCXD01007264             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:14363:12568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007264
VERSION     KCXD01007264.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:14363:12568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65746.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       446..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          105 a          115 c          155 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctcggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      241 catgcactgg gtccgccagg ctccagggag ggggctggag tgggtggcag ttatgtcgtc
      301 tgatggaagt aacatatact acgcagcctc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgttat atcttcaaat gaacaacctg caatttgagg acacggccgt
      421 gtattactgt gcgagagatg tgtacggtag tgggttagac tactggggcc tgggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007265             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:12156:14183
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007265
VERSION     KCXD01007265.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:12156:14183"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..502
     V_segment       142..435
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65747.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       442..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          105 a          121 c          156 g          122 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcactaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgcag ctggtggagt ctgggggcgg cttggtgaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcag ttatttctac
      241 atgagctggg tccgtcaggc tccaggaaag gggctggagt ggatctcaag tattgacaat
      301 ggtgggacta ccacaaattt tgcagactcc gtgaggggca ggttcaccat ctccagagag
      361 aacgccaaga acacactgta tcttcaaatg gacagcctga gagctgagga cacggctgtc
      421 tattattgtg cgagagcgcg cggggtgatc attacatact ttgactcctg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007266             358 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:18881:15375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007266
VERSION     KCXD01007266.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:18881:15375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..356
     V_segment       5..272
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <266..>325
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65748.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       292..303
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       315..356
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>358
                     /gene="IGHG"
BASE COUNT           80 a           86 c          111 g           81 t
ORIGIN      
        1 acatgggggc ttgacaaagc ctggggggtc cctgagactc tcctgtgcgg cctccggatt
       61 caccttcagt gactactata tggactgggt ccgccaggct ccagggaagg ggctggagtg
      121 ggtctcacga atcagtcatg atggtgatag cacatggtac gcagactccg tgaagggcag
      181 atttaccatt tccagagaga atgccaagaa cacactgttt cttcaaatgg acagcctgag
      241 aagtgaggac acagccgtat attactgtgc gagagagcgt tttgggggaa ttggggtgat
      301 tatcttcaac tggatcgatg tctggggccc gggagtcctg gtcaccgtcc cctcagcc
//
LOCUS       KCXD01007267             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10932:14555
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007267
VERSION     KCXD01007267.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10932:14555"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65749.1"
                     /translation="CAREYCTSTSCAGFLDSW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          145 c          135 g          104 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct gcaggtgtcc
      121 agtcccaggt ccgcctggtg cagtccggga ctgaggtgaa gaagcctggg gcctcagtga
      181 agatttcctg cggggcttct ggattcaccc tcgacaccta tggtatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat cccccttatt ggtatcatca
      301 actacgcaga caactctcag ggcagactca caataaccgc gaacacgtcc actcatacaa
      361 cctatatgga actgagcagt ctgagagctg aggacacggc catctactac tgtgcgagag
      421 aatactgtac ttctactagt tgcgccgggt tccttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007268             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26341:6782
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007268
VERSION     KCXD01007268.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26341:6782"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65750.1"
                     /translation="CASGTFGTSVWSSLFYGLDSW"
     D_segment       436..442
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          116 a          139 c          148 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtaaaggt
      181 ctcctgccag gtttccggag acaccttcag tgaaatgtcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggatg tgttgctcct ggaaatgggg aaataataca
      301 cgcagataac ttccagggca gagtcaccat gaccgaggac acgtctatag acacagccta
      361 catggagctg agtagcctga gatctgagga cacggccgta tattactgtg cgagcgggac
      421 atttgggacc agcgtctggt ccagcctctt ctacggtttg gattcctggg gccaaggggt
      481 cgtcgtcagc gtctcctcag cc
//
LOCUS       KCXD01007269             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:8826:3947
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007269
VERSION     KCXD01007269.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:8826:3947"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65751.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       446..451
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          109 a          116 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagag cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtatctctgg
      241 catgcactgg gtccgccaga ctccagggaa ggggctggag tgggtggcag ttaaatcgtt
      301 tgatggaact aagatatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggaag acacggccgt
      421 ttattactgt gtgagggatg cctacgggag cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007270             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:12608:5352
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007270
VERSION     KCXD01007270.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:12608:5352"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..485
     V_segment       124..417
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65752.1"
                     /translation="CARYEDDSGHYYFDSW"
     D_segment       426..434
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>489
                     /gene="IGHG"
BASE COUNT           95 a          138 c          137 g          119 t
ORIGIN      
        1 acatggggag ggtccagctt acatgggaaa tgctctctga gagtcatgga cctcctgtgc
       61 aagaacttga agcacctgtg gttcttcctt ctcctggtgg cagctcccag atgggtcctg
      121 tcccaggtgc agttgcagga gtcgggccca ggactggtga agccctcgga gaccctgtcc
      181 ctcatctgcg ctgtctctgg tggctccatc accagtagct tctggagctg gatccgccag
      241 cccccaggga agggactgga gtggattggg tatatatatg gtagtactgg gagttccagt
      301 tccaacccct ccctcaagag tcgagtcacc atttcaacgg acacgtccaa gaaccagttt
      361 tccctgaaac tgagctctgt gaccgccgcg gacaccgcct tttatttctg tgcgagatat
      421 gaagatgata gtggtcatta ctactttgac tcctggggcc agggagtcct ggtcaccgtc
      481 tcctcggcc
//
LOCUS       KCXD01007271             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:9991:9567
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007271
VERSION     KCXD01007271.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:9991:9567"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..472
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65753.1"
                     /translation="CARAGYSGSESFYGLDVW"
     D_segment       403..414
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..472
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           91 a          139 c          136 g          108 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gctcctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccagctgca gctgcaggag
      121 tcgggcccag gactggtgaa gtctttgggg accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gtagtaacta ctggagctgg atccgccagc cccccgggaa gggactcgaa
      241 tggattggac gtttctctgg tagtggtgga aacaccgact acaacccctc cctcaagact
      301 cgagtcacct tttcaacaga cacgtccaag aaccagttct ccctgaggct gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagccg gatatagcgg cagcgaaagt
      421 ttctacggtt tggatgtttg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007272             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8636:19502
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007272
VERSION     KCXD01007272.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8636:19502"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65754.1"
                     /translation="CARSQSYCSGLYCFGYYYFDYW"
     D_segment       403..425
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..482
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           93 a          141 c          134 g          116 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtccagtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcagagac cctgtccctc atctgcgctg tctctggtgg
      181 ctccatcagt actcactggt ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctccggta gtggtgggag caccaggtat aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga gttctgtgac
      361 cgccgcggac acggcctttt attattgtgc gagatcccaa tcatattgta gtgggcttta
      421 ctgcttcggc tactactact ttgactactg gggccaggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01007273             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8886:18972
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007273
VERSION     KCXD01007273.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8886:18972"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65755.1"
                     /translation="CARGYCTGSGCNLTFNRLDVW"
     D_segment       421..440
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          110 a          141 c          145 g          108 t
ORIGIN      
        1 acatggggga cacataacaa ccacgtccct cctctaaaga agcccctggg aacacagctc
       61 atcaccatgg acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag
      121 tctcaggtcc agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag
      181 ctctcctgta aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag
      241 gcccctggac aagggcttga gtggatggga ggcatcttcc ctcttgttgg tacaacaaac
      301 tacgcacaga agttccaggg cagagtcacg attaccgcgg acacgtccac aagcacagcc
      361 tacatggacc tgagcagcct gggatctggg gacacggcca tgtattattg tgcgagaggt
      421 tactgtactg gtagtggttg taaccttaca ttcaaccggc tcgatgtctg gggcccggga
      481 gtcccggtca ccgtctcctc agcc
//
LOCUS       KCXD01007274             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:13752:8623
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007274
VERSION     KCXD01007274.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:13752:8623"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65756.1"
                     /translation="CVRDGYGSGLDAW"
     D_segment       446..455
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          111 a          108 c          161 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcgggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gcacgtttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttataacgaa
      301 tgatggaagt aagaattact acgcagactc tgtgaaggac cgattcaccg tctccagaga
      361 caattccaag aatatggtat atattcaaat gaacaacctg aaattggagg acacggccgt
      421 ttattactgt gtgagagatg ggtacggtag tggtttggat gcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007275             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14359:11496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007275
VERSION     KCXD01007275.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14359:11496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65757.1"
                     /translation="CARDVWGRGFDYW"
     D_segment       434..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          110 c          157 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 ttagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtact tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaca tcgtctgatg
      301 aaagtaataa atactacgca gactctgtga aggcccgatt caccgtctcc agagacaatt
      361 ccaagaaaat gttatatctt caaatggaca acctgaaatt ggaagacacg gccgtgtatt
      421 actgcgcgag agatgtctgg gggaggggat ttgactattg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007276             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7329:11808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007276
VERSION     KCXD01007276.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7329:11808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65758.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       442..447
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          104 a          125 c          156 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac acaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccatt gtgaggtgca gctggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctaagac tctcctgtgc agcatccgga ttcagcttca gtgaccactg
      241 catgcactgg gtccgccagg cttcagggaa ggggctggag tgggtctcag gtattactta
      301 tactggtgtt accacatggt acgcagactc cgtgaggggc agattcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agacctgagg acacggctgt
      421 ctattactgt gtgggaggaa ggcggcacgt ggaccttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007277             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17069:13657
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007277
VERSION     KCXD01007277.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17069:13657"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65759.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       418..424
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          112 a          141 c          136 g           98 t
ORIGIN      
        1 acatggggac acaacagcca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctgcaggcg cccgctctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcgaggtt tccggataca ccttcaccga actgtccatc cactgggtgc gacaggcccc
      241 tggaaaaggc cttgagtgga tgggaagtgt tgatcctgaa tatggtgaaa tgataaacgc
      301 agaaaacttc cagggcagag tcaccttgac cgaggacacg tctacaggaa cggcctacat
      361 ggagctgatc agcctgagat ctgaagacac ggccgtgtat tactgtgcga catcacccag
      421 cggcaattgg cttttttggt acttcgattt ttggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007278             332 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20515:18290
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007278
VERSION     KCXD01007278.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 332)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 332)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20515:18290"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..329
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..329
     V_segment       8..267
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>299
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65760.1"
                     /translation="CATADYGNSLDFW"
     D_segment       273..284
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       289..329
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        330..>332
                     /gene="IGHG"
BASE COUNT           79 a           86 c           88 g           79 t
ORIGIN      
        1 acatgggggt tcagcctggg gggtccctga gactctcctg tgcagcctct ggattcacct
       61 tcagtagctt tggcttgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgg
      121 cagttatatc gtctgatgga aatatgaaat actacgcaga ctctatgaag gaccgattca
      181 ccatctccag agacaattcc aagaacatac tatatcttca agtgaacaac ctgaaattgg
      241 aagacactgc cgtttattac tgtgcgacag ccgactacgg taacagcctt gacttctggg
      301 gccagggagt cctggtcacc gtctcctcaa cc
//
LOCUS       KCXD01007279             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:14928:13083
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007279
VERSION     KCXD01007279.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:14928:13083"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65761.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          141 c          136 g           95 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctcaatatg gtgaaatgat
      301 agacgcagag aaattccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtgctt cgatatctgg ggccctggca ccccgatcac
      481 catctcctca gcc
//
LOCUS       KCXD01007280             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18557:10184
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007280
VERSION     KCXD01007280.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18557:10184"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..392
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65762.1"
                     /translation="CAKKYSGSYFYGHYDYW"
     D_segment       398..413
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT          100 a          133 c          131 g          105 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaaac cttcggagac cctgtccctc acctgcgctg tctctggtgc
      181 ctccatcagt gattactggt ggaactggat ccgccagcca ccagggaagg gactggagtg
      241 gattgcggag atcaatgttg atagtggtac cacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa ccagttctcc ctgaaggtga cttctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gaaaaagtat agtggcagtt atttctacgg
      421 acactatgac tactggggcc agggagtctt ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007281             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19209:5364
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007281
VERSION     KCXD01007281.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19209:5364"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65763.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          120 c          152 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggggga ggcttggttc
      181 gccctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcgctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttttgtcgt
      301 ctgatggagg ttacaaatac cacgcagact ctaagaagga ccgattcacc atctccagag
      361 acaattccaa gaacatccta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagaggg gaatacagta actctattga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007282             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:9087:11827
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007282
VERSION     KCXD01007282.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:9087:11827"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65764.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          136 c          128 g          109 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcggc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactgggt ccgccagccc ccagggaagg gactggaatg
      241 gattgggtat atctctggtg cttatgggag caccaactac aacccctctc tcaagagtcg
      301 agtcaccatt tcactagaca cgtccaagag ccacttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtat attactgtgt gagatatgag gatgaatcca ttaattacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007283             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:22938:8902
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007283
VERSION     KCXD01007283.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:22938:8902"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65765.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       432..442
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          145 c          141 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct ccccaacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctggacaa gggcttgagt ggatgggact tgttgatcct gtaaatggtg aactaataca
      301 cgcagacaag ttccagggca gagtcaccat gaccgaagac acgtctacag acacagccta
      361 catggagttg agcagcctga catctgagga cacggccatc tactactgtg cgacagggag
      421 gatcggtacc agtggctggt ccaacctctt caatggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcttcag cc
//
LOCUS       KCXD01007284             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21972:16921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007284
VERSION     KCXD01007284.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21972:16921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..463
     V_segment       94..390
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65766.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       406..413
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           99 a          138 c          129 g           99 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtga agctgcagga gtcgggccca
      121 ggactggtga agccttcaga gaccctgtcc ctcacctgcg ctgtctctgg aggctctatc
      181 agcggtgttt atgactggag ctggatccgc cagcccccag ggaaggggct ggagtggatt
      241 gggtatgtcc atggtaatac tgggaacacc gactacaacc cgtccctcaa gaatcgagtc
      301 accatttcaa aagacacgtc caagaaccag ttctccctga cgctgaggtc tgtgaccgcc
      361 gcggacacgg ccgtatatta ctgtgcgaga cgcccagaaa acagttacta cttctactac
      421 tttgactact ggggccacgg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007285             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:17443:5553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007285
VERSION     KCXD01007285.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:17443:5553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65767.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          115 a          142 c          129 g           90 t
ORIGIN      
        1 atggggatca cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttctggatac accttaaccg accactacct gcactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggtg ttcatcctga atatgggaaa gtagactaca
      301 cacagaagtt ccaagacaga gtcaccatca ccgcggacat gtcgacagag acagtctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccactta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgactac tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007286             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20147:19050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007286
VERSION     KCXD01007286.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20147:19050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..392
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65768.1"
                     /translation="CAGGSRRQPENW"
     D_segment       404..411
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           82 a          131 c          141 g          101 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctatgcaa gagcatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cggttactgg tggggctgga tccgccagcc cccagggaag gggctggagt
      241 ggattgggta tatcggtggt actagtggga gtacctacta caatccctcc ctcgagagtc
      301 gagtcaccat ttcaacagac acgtccaaga atctcttctc cctgaagatg agttctttaa
      361 ccgtcgcgga cacggccatg tatttctgtg cgggcggaag tcggcggcag ccggagaact
      421 ggggccaggg agtcctggtc accgtctctt cagcc
//
LOCUS       KCXD01007287             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:16491:17552
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007287
VERSION     KCXD01007287.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:16491:17552"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..478
     V_segment       94..390
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <382..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65769.1"
                     /translation="CARSQSYCGGLYCFGYYYFDYW"
     D_segment       413..421
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT           92 a          142 c          132 g          114 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtgc agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg tggctctttc
      181 agcagtacta aatggtggag ttggatccgc cagcccccag ggaaagggct ggagtggatt
      241 gggtatatca gtggtagtag tggtaacacc ttctacaacc cctccctcaa gagtcgagtc
      301 accatttcaa cggacacgtc caacaaccag ttctccctga agctgacctc tgtgaccgcc
      361 gcggacacgg ccgtttatta ttgtgcgaga tcccaatcct attgtggtgg cctttactgc
      421 ttcggctact actactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007288             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:18376:12950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007288
VERSION     KCXD01007288.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:18376:12950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..505
     V_segment       139..424
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65770.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       440..447
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          116 a          122 c          144 g          125 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagttt atgctgagct gggttttcct tgtttctata
      121 ttaaaaggtg tccagtgtgt ggaccatctg gtggagtctg ggggaggctt ggtacagccc
      181 ggggcctccc tgagactctc ctgtgcagcc tctgaattca ccttcagtgc ctatgacatg
      241 cactgggttc gccaggctcc agggaagggt ctagaatggg tatcaggtat taacattggc
      301 ggtgacccat actacccaga ctctgtgaag gggcgattca ccatctccag agacaatgcc
      361 aagaactcct tgtatcttca aatgaacaac ctgagagctg aggacactgc tgtgtattat
      421 tgtgtgaggg ggatggataa ctaccactac agtaatacgg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007289             526 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22198:17262
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007289
VERSION     KCXD01007289.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 526)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 526)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22198:17262"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..524
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..524
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>493
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65771.1"
                     /translation="CTAEITVEIVATPRSYDYW"
     D_segment       451..476
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       484..524
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        525..>526
                     /gene="IGHG"
BASE COUNT          122 a          128 c          151 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gagacttagt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcagtgacta
      241 tgccatgggc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagcaactat aaccattacg cgacagaata cgccgcatcg gtgaaaggca gattcaccat
      361 ctccagagat gattcaaaga acacgctata tttgcaaatg agcagcctga aaaccgagga
      421 cacggccgtg tattactgca ccgcagaaat cactgtagag atagtggcta ctcctcgttc
      481 ttatgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007290             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:25777:11357
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007290
VERSION     KCXD01007290.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:25777:11357"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..412
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <404..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65772.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       413..418
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          115 a          142 c          130 g           88 t
ORIGIN      
        1 acatggggac acaaccacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggaggc tcctcctctt ggtggcagca gctacaggcg cccactccga
      121 ggtccagctg gtacagtctg gggctgaggt gaagaagcct ggggcctccg tgaaaatctc
      181 ctgccaggct tctggataca ccttaaccga ccactacctg cactgggtgc gacaggctcc
      241 tggaaaagga cttgagtgga tgggaggtgt tcatcctgaa tatgggaaag tagactacac
      301 acagaagtgc caagacagag tcaccatcac cgcggacatg tcgacagaga cagtctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccacttat tactgtgtga cagtgggtcc
      421 ctaccattac tttgactact ggggccaggg agccctggtc accgtctcct cagcc
//
LOCUS       KCXD01007291             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15923:11755
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007291
VERSION     KCXD01007291.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15923:11755"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65773.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          142 c          149 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgaaatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tggccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgacg acacggccgt atattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01007292             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:13902:17846
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007292
VERSION     KCXD01007292.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:13902:17846"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65774.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          114 c          153 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag agatgtccag tgtgaggtgc acctggtgga atctggagga ggatcggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcattcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgagac taagagatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007293             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:14709:2736
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007293
VERSION     KCXD01007293.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:14709:2736"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65775.1"
                     /translation="CARAHSGSWNNWYFDLW"
     D_segment       422..437
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          127 a          144 c          129 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgatga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagattc accgaatcat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga atggatggga agtgttgatc ctgaatatgg tgaaatgata
      301 aacacagaga aattccagga cagagtcacc ctgaccgagg acacgtctac agacacagcc
      361 tacatggatc tgaacaccct gagatctgac gacacggcca tctattactg tgcgagagcc
      421 catagcggca gctggaataa ctggtacttc gatctctggg gccctggcac cccaatcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01007294             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:13753:19462
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007294
VERSION     KCXD01007294.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:13753:19462"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..469
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65776.1"
                     /translation="CARVDSSGWYLPALDVW"
     D_segment       401..417
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..469
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT           83 a          141 c          141 g          106 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctacaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtttctggt
      181 ggctccatca gcagttacta ctggacctgg atccgccagc ccccagggaa gggactggag
      241 tggattggac gtctctttgg tagtagtggg agcaccagtt acaacccctc cctctcgagt
      301 cgagtcacct tttcaacaga cacgtccaag aaccagttct ccctgacgct gggctctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagtgg atagcagcgg ctggtacttg
      421 ccggcattgg atgtctgggg ccggggagtt ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007295             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:17712:11444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007295
VERSION     KCXD01007295.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:17712:11444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65777.1"
                     /translation="CARNRFMGIRVLAYW"
     D_segment       407..413
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           96 a          133 c          130 g          104 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtccagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagt ggttactact ggaactggat ccgccaacca ccagggaagg ggctggagtg
      241 gattgggtat atcgctggta gtagtgggag tacctactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagctga actctgtgac
      361 cgccgcggac acggccatct attactgtgc gagaaataga tttatgggta taagggttct
      421 tgcctactgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007296             456 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14157:6074
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007296
VERSION     KCXD01007296.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 456)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 456)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14157:6074"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..454
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..454
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>423
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65778.1"
                     /translation="CARYQGDSLYYFDYW"
     D_segment       393..400
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       407..454
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        455..>456
                     /gene="IGHG"
BASE COUNT           84 a          135 c          128 g          109 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tggctccatc
      181 agcgattact tctggaactg gatccgccag tccccaggga gggggctgga gtggattgga
      241 tatctctatg gtgctactgg gatcaccggc tacaacccct ccctcaagag tcgagtcacc
      301 ttttcagcag acacgtccaa gaaccagttt tccctgaagc tgacctctgt gaccgccgcg
      361 gacaccgccg tttattattg tgcgagatat cagggtgatt ccttgtacta ctttgactac
      421 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007297             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:17261:11452
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007297
VERSION     KCXD01007297.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:17261:11452"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..397
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65779.1"
                     /translation="CARWSAANFDYW"
     D_segment       402..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       411..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           87 a          134 c          135 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcaac tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagt agtggttatg gctggagctg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tgtctctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttcaatag acacgtccaa gaaccagttc tccctgaagc tgaggtctat
      361 gaccgccgcg gacacggccg tgtattactg tgcgcgatgg tcggcagcca actttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007298             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18398:17349
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007298
VERSION     KCXD01007298.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18398:17349"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..417
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <409..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65780.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       418..423
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..478
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          115 a          143 c          130 g           92 t
ORIGIN      
        1 acatgggggc atcacacaac caccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggctcctc ctcttggtgg cagcagctac aggcgcccac
      121 tccgaggtcc agctggtaca gtctggggct gaggtgaaga agcctggggc ctccgtgaaa
      181 atctcctgcc aggcttctgg atacacctta accgaccact acctacactg ggtgcgacag
      241 gctcctggga aaggacttga gtggatggga ggtgttcatc ctgaatatgg aaaagtagac
      301 tacacacaga agttccaaga cagagtcacc atcaccgcgg acatgtcgac agagacagtc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tttattactg tgtgacagtg
      421 ggtccctacc attactttga cttctggggc cagggagccc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007299             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18775:8694
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007299
VERSION     KCXD01007299.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18775:8694"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65781.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       438..444
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          113 c          148 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgc ccagtgtgag gtacaattgg tggagtctgg aggaggtttg ggtcagcctg
      181 gggggtccct gagactctcc tgtgaaactt ctggattcac cttcagtaat tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtatgatg
      301 taagtaagac atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ctaagaacat gctatatctt caaatgagca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgcgag acgcccttgg aacgctgact actttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007300             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:23125:16206
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007300
VERSION     KCXD01007300.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:23125:16206"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65782.1"
                     /translation="CARVSGRWELFEPGSEDYW"
     D_segment       409..418
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           94 a          137 c          142 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tacaggagtc
      121 gggcccagca gtggtgaagc cttcggacac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtgtttatg gctggagctg gatccgccag gcccccggga agggactgga
      241 atggattgga tatgtctatg gcagtagcgg tagcacctac tacaacccct ccctcaagag
      301 tcgaatcacc atttcagaag acacgtccaa gaaccagttc tccctgaacc tgaactctgt
      361 gacggccgcg gacacggccg tatattactg tgcgagagtt tcgggcaggt gggagctatt
      421 tgagcctggg tcagaggact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007301             415 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24607:11508
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007301
VERSION     KCXD01007301.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 415)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 415)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24607:11508"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    32..411
                     /note="immunoglobulin heavy chain variable region"
     V_region        32..411
     V_segment       32..324
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <317..>382
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65783.1"
                     /translation="CASPPRYCSGGVCYAAEYFEFW"
     D_segment       334..361
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       362..411
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        412..>415
                     /gene="IGHG"
BASE COUNT           93 a          112 c          126 g           84 t
ORIGIN      
        1 acatggggca gcaactacag gcgcccactc tgaggtccaa ctggtgcagt ctggggctga
       61 ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag gtttccggat acaccttcac
      121 cgaattatcc atccactggg tgcgacaggc ccctggaaaa ggccttgagt ggatgggagg
      181 tgttgatcct gtatatgatg gaataacaca cgcagagaag ttccagggca gagtcaccat
      241 gaccgaagac acgtcgacag acacagccta catggaactg agtggcctga gatctgagga
      301 cacggccgtg tattactgtg cgagcccccc cagatattgt agtggtggtg tctgctacgc
      361 cgctgaatac ttcgagttct ggggccaggg cgccctggtc accgtctcct ccgcc
//
LOCUS       KCXD01007302             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18396:7455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007302
VERSION     KCXD01007302.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18396:7455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65784.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       421..434
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          143 c          134 g           99 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cgcagcacct
       61 caccatggac tggacctgga ggatcctcct cttagtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcag cgatttatcc atacactgga tacgacaggc
      241 ccctggaaaa gggcttcagt ggatgggaag tgttgatcct gcttttggtg aaatgataaa
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcttcag acacagcctt
      361 catggaattg agcagcctga aatctgacga cacggccgtg tatttctgtg cgagtggccc
      421 tagcggcacc tggatcgact ggtccttcga tgtctggggc cctggcaccc caatcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007303             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:21383:7607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007303
VERSION     KCXD01007303.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:21383:7607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65785.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       408..412
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          137 c          132 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc agctgcgctg tctctggtgg
      181 cgccatcagc agtggtttct actggacctg gatccgccaa cccccaggga aggggctgga
      241 gtggattggg tgtatcggtg gtaatagtgg aaccacctac tacaacccct ccctcaagag
      301 tcgagccgcc atttcaaaag acacgtccaa caatcaactc tccctgaggt tgagttctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagat gaagacccct ccatttttga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007304             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24202:13398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007304
VERSION     KCXD01007304.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24202:13398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    76..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        76..442
     V_segment       76..369
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65786.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       379..387
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       398..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT           99 a           95 c          141 g          109 t
ORIGIN      
        1 acatggggag gactcaccat gaagtttggg ctgagctggg ttttccttgt tgttatttta
       61 agaggtgtcc agtgtgaggt gcaactggtg gagtctggag gaggcttggt tcagcccggg
      121 gggtcactga gactgtcctg tgcagcctct ggattcacct tcagtagctc tggcatgcac
      181 tgggtccgcc aggctccagg gaagggactg gagtgggagg cacttatatc taatgatgga
      241 agtaagaaat attacgcaga ctccgtgaag gaccgattca ccatctccag agacaattcc
      301 aagaacatgc tgtatcttca aatgaacaac ctgaaattgg atgacacggc cgtgtattac
      361 tgtgcgcgag ttggagaggg tagtggtggt gcggaggact ttgactactg gggccaggga
      421 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007305             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:7640:5792
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007305
VERSION     KCXD01007305.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:7640:5792"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..468
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65787.1"
                     /translation="CARYDQWDDYLYYFDYW"
     D_segment       408..417
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>471
                     /gene="IGHG"
BASE COUNT           93 a          139 c          130 g          109 t
ORIGIN      
        1 acatggggat ggtctctgag agtcatgggc ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctat cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtaccta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattggat ttatctatgg tgctactggg agcaccggct acaacccctc cctcaagagt
      301 cgagtcacca tctcaacaga cacgtccaag aaccagtttt ccctgaagct gacctctgtg
      361 accgccgcgg acagcgccgt gtattactgt gcgagatatg atcagtggga tgattacctg
      421 tactactttg actactgggg tcagggagtc ctggtcaccg tctcctcatc c
//
LOCUS       KCXD01007306             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8656:20116
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007306
VERSION     KCXD01007306.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8656:20116"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65788.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       440..446
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          121 c          147 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcatcttc agtaactatg
      241 ccatgcactg ggtccgccag gctccaggga aggggctaga gtgggtggca gttatttcgc
      301 atgatggaac taagaaatac tacacagact ctgcgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatacaa tatcttcaca tgaacagcct gaaattggag gacacggcca
      421 tatactactg tgcggcctcc tacttggggt acggttttga gtactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007307             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:25441:17997
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007307
VERSION     KCXD01007307.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:25441:17997"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65789.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          136 c          128 g          111 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccag atgggtcctg tcccaggtgc agctgctgga
      121 gtcgggcccg ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcactagtt actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007308             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:4338:8005
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007308
VERSION     KCXD01007308.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:4338:8005"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-103"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65790.1"
                     /translation="CTRNRNTVMIGWFDVW"
     D_segment       443..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          108 a          121 c          160 g          120 t
ORIGIN      
        1 acatgggggc tctgagagag gagccttagc cctggatttc aaggcacttc cacctgggga
       61 tcagcactga acacagagga cccaccatgg agttggggct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccgg tgtgaggtgc agttggtgga gtctggggga ggcttggtcc
      181 agcctggagg gtctctgaga ctctcctgtg tagcctctgg attcagcttc agaagttacg
      241 aaatgagttg ggtccgccag gctccgggaa aggggctgga gtgggtctca tatattagtc
      301 acactggtga aaccatatac cacgctgact ccgtgaaggg ccgattcacc atctccagag
      361 acaacgccaa gaattcgctg tctctgcaaa tgagcagcct gagagccgag gacacggccg
      421 tgtattactg tactaggaac cggaatactg taatgattgg gtggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007309             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6524:8627
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007309
VERSION     KCXD01007309.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6524:8627"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65791.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          108 a          113 c          158 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggaggc ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagtagtg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctggct gttgaatcgc
      301 atgatggaaa taagaaatat tatgcagact ccgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtg tatcttcaaa tgaacaacct gaacttggtg gatacggcca
      421 tgtattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007310             435 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:17577:14377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007310
VERSION     KCXD01007310.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 435)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 435)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:17577:14377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    188..433
                     /note="immunoglobulin heavy chain variable region"
     V_region        188..433
     V_segment       188..353
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>402
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65792.1"
                     /translation="CASGPTTIFGMLVTGLDFW"
     D_segment       363..375
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       392..433
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        434..>435
                     /gene="IGHG"
BASE COUNT          103 a          123 c          118 g           91 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggtctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gccttgagtg gatgggagtt gttgatcctt tggataatga aataatatac
      241 gcagacaact tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac
      301 atggaactga gcagcctgac ctctgacgac acggccatct attactgtgc gagtgggcct
      361 actacaattt ttggaatgct tgttacgggg cttgacttct ggggccaggg agtcctggtc
      421 accgtctcct cagcc
//
LOCUS       KCXD01007311             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:24085:6837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007311
VERSION     KCXD01007311.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:24085:6837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..509
     V_segment       143..432
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65793.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       450..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          113 a          116 c          151 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacatgac tcaccatgga gtttatgctg agctgggttt tccttgttgc
      121 tatgttaaaa ggtgtccagt gtgtggagca gctggtggaa tctgggggag gcttggtaca
      181 gcctggggcg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttga
      241 catgcactgg gttcgccagg ctccagggaa gggtctggac tgggtatcag gtattaacat
      301 tggcggtgac acatactacc cagactctgt gaagggtcga ttcactatgt ccagagacaa
      361 tgccaagaac tccgtgtatc ttcaaatgaa cagcctgaga gttgaggaca ctgctgtgta
      421 tttttgtgca agggggatag ataactacca ctatagtgat acggactttg actactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007312             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:5671:10033
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007312
VERSION     KCXD01007312.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:5671:10033"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65794.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       441..449
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          112 a          111 c          151 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgcgatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggaggcttgg ttcagccgga
      181 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtttct atggcataca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttattt cgaatgatga
      301 aactaagaaa tactacgcag actctgtgaa ggaccgattc accatttcca gagacaattc
      361 caagaacatg ctatttcttc aaatggacaa cctgaaattg gaggacacgg ccgtctatta
      421 ttgtgtgaga gatgatttag gcagcggctt agggtcctgg ggccagggag tcctggtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007313             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:20681:12270
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007313
VERSION     KCXD01007313.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:20681:12270"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65795.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       419..427
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          110 a          141 c          134 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcaactacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa acaccttcac cgaattgtcc atgcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgacgtt
      301 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggaactgag
      361 cagcctgaca tctgaggaca cggccgtgta ttattgcgcg attggcccta gtggcagatg
      421 gaacgactgg tccttcgaca tctggggacc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01007314             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:21720:14628
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007314
VERSION     KCXD01007314.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:21720:14628"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..484
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65796.1"
                     /translation="CAKGPGVIINYFDYW"
     D_segment       427..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          100 a          145 c          133 g          108 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgta agacttctgg atacagcttt accagctact ggatcacctg ggtgcgccag
      241 atgcccggga aaggcctgga gtggatgggg gcaattgatc ctagtgattc tgctaccaaa
      301 tacagcccgt ccttccaagg ccaggtcacc atttcagccg acaagtccat caccaccgcc
      361 tacctggagt ggagcagcct gaaggcctcg gacaccgcca cgtattactg tgcgaaaggt
      421 cccggagtga ttattaacta ctttgactac tggggccagg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01007315             289 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14688:12027
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007315
VERSION     KCXD01007315.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14688:12027"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    3..287
                     /note="immunoglobulin heavy chain variable region"
     V_region        3..287
     V_segment       3..226
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <218..>256
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65797.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       237..241
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       245..287
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        288..>289
                     /gene="IGHG"
BASE COUNT           64 a           85 c           79 g           61 t
ORIGIN      
        1 acatgggggc gccatcagca gtggtttcta ctggacctgg atccgccaac ccccagggaa
       61 ggggctggag tggattgggt gtatcggtgg taatagtggt accacctact acaacccctc
      121 cctcaagagt cgagccacca tttcaaaaga cacgtccaac aatcaactct ccctgaaggt
      181 gagttctgtg accgccgcgg acacggccgt gtattactgt gcgagagatg aagacccctc
      241 catttttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007316             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:7673:10409
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007316
VERSION     KCXD01007316.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:7673:10409"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..470
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65798.1"
                     /translation="CARDPRWQLELLFFDYW"
     D_segment       408..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          142 c          135 g          102 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccaa atgcgtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccttc agcaacttct actggaactg gatccgccag accccaggga aggggctgga
      241 gtggattggg tgtatcagtg gtgatagtgg gagcaccgac tacaacccct ccctcaagag
      301 tcgagtccac atttcgacag acacgtccaa gaaacagttc tccctgaaga tgagctctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagagac ccccggtggc agctggaact
      421 cctcttcttt gactattggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007317             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7008:21810
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007317
VERSION     KCXD01007317.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7008:21810"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    134..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        134..488
     V_segment       134..427
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <419..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65799.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       436..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          111 c          149 g          116 t
ORIGIN      
        1 acatggggga ggagcccagc cctggaagtc cacagtgttc cattcggtga tcagcacaga
       61 acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
      121 aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc agcctggggg
      181 gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg gcatgcactg
      241 ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt atgatgtaag
      301 taagaaatac tacgcagacg ctgtgaagga ccgattcacc atctccagag acaattccaa
      361 gaacacccta tatcttcaaa tgaacaacct gaaattggag gacacggccg tgtattactg
      421 tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007318             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:9876:10767
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007318
VERSION     KCXD01007318.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:9876:10767"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..480
     V_segment       114..407
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65800.1"
                     /translation="CARELYNSGWADAFDFW"
     D_segment       413..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          103 a          102 c          156 g          121 t
ORIGIN      
        1 acatggggtc cacagtgttc cattcggtga tcagcacaga acacagagga ctcaccatga
       61 agtttgggct gagctgggtt ttccttgttg ctattttaag aggtgtccag tgtgaggtgc
      121 agctggtgga gtctggagga ggcttggttc agcctggggg gtccctgaga ctctcctgtg
      181 cagcctctgg attcatcttc agtagttatg gcatgcattg ggtccgccag gctccaggga
      241 aggggctgga gtgggtggca ggtgtgtcgt atgatgggag tgagagtgac tacgcagact
      301 ctgtgaagga ccgaatcacc atttccagag acaattccaa gaacatggta tatgttcaaa
      361 tgaacagcct gaaattggag gacacggccg tgtattactg tgcgagagag ctgtataaca
      421 gcggctgggc tgatgccttt gatttctggg gccaagggct cagggtcacc gtctcttcag
      481 cc
//
LOCUS       KCXD01007319             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:24170:5733
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007319
VERSION     KCXD01007319.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:24170:5733"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65801.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          120 a          142 c          125 g          100 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctgggtctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatcc ctgcactggg ttcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag ttttaatcct atatatggtg aaattttaca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007320             440 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:19612:17863
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007320
VERSION     KCXD01007320.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:19612:17863"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    75..438
                     /note="immunoglobulin heavy chain variable region"
     V_region        75..438
     V_segment       75..368
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <360..>407
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65802.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       382..387
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       394..438
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        439..>440
                     /gene="IGHG"
BASE COUNT           91 a          103 c          137 g          109 t
ORIGIN      
        1 acatgggaga acataccatg gagtttgtgc tgagctgggt tttccttgtt gctcttttga
       61 aaggtgtcca gtgtgaggtg cagttggtgg agtctggggg cggcttggca aagcctgggg
      121 ggtccctgag actctcctgc gcagcctctg gattcagctt cagttactac tacatgagtt
      181 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattgcc gctgatgggg
      241 atagcacata ctatgcagac tccatgaagg ccagattcac tatctccaga gagaacgcca
      301 agaacacact gcatcttcaa atggacagcc tgagagcaga ggacacggct gtctattact
      361 gtgtgagaga tcgacgtgtt cagtcgttat cctggttcga tgtctggggg ccgggagtcc
      421 tgatcaccgt ctcctcagcc
//
LOCUS       KCXD01007321             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:11209:11022
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007321
VERSION     KCXD01007321.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:11209:11022"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..464
     V_segment       83..380
                     /gene="IGHV2-69"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <371..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65803.1"
                     /translation="CARDYCSGIYCDVNGHYFDLW"
     D_segment       386..403
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT          105 a          138 c          118 g          105 t
ORIGIN      
        1 acatggggga atcctgtgcc ccaccatgga cacgctttgc tacacactcc tgctactgac
       61 cgtcccgtcc tgggccttgt cccaggtcac cttgaaggag tctggtcctg cgctcgtgaa
      121 acccacacag accctcacgt tgacctgcac cttctctggg ttctcaatca gctctactgg
      181 aagaggtgtg ggctggatcc gtcagccccc agggaaggcc ctggaatggc ttgcaaccat
      241 ttattggaat gatagtaaat actacagcac atcgctgaag agcaggctca ccgtctccaa
      301 ggacacctcc aaaaaccagg tggttctgac aatgaccaac atggaccctg tggacacagc
      361 caaatattac tgtgcacggg attactgtag tgggatttac tgcgatgtaa atgggcacta
      421 ctttgacctc tggggccagg gagtcctggt cgccgtctcc tcagcc
//
LOCUS       KCXD01007322             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11563:21354
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007322
VERSION     KCXD01007322.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11563:21354"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <430..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65804.1"
                     /translation="CASGGNTYEWYFEIW"
     D_segment       445..451
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..505
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          110 a          134 c          151 g          112 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaagtg cagctggtgg agtctggagg aggcttggtc
      181 cagcccgggg ggtcccagag actctcctgt gcagcctctg gattcacctt cactagttat
      241 gtcataacct gggtccgcca ggctccaggg agggggctgg agtgggtctc atccattagt
      301 attggtggtg tgaggacata ctacgcagac tccgtgaagg gccgattcac catttccaga
      361 gacaactcaa agaacacgct ctccctgcaa atgaacagcc tgagaactga ggacacggcc
      421 gtgtattact gtgcctccgg aggtaacacc tacgagtggt acttcgagat ctggggccct
      481 ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01007323             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:13015:5102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007323
VERSION     KCXD01007323.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:13015:5102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..389
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65805.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       395..409
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           93 a          135 c          126 g          105 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacatgcg ctgtctctgg tgactctatc
      181 agcagtagtc actggtggag ctggatccgc cagcccccag ggaaaggcct ggagtggatt
      241 ggctatatca gtggtagtgg tgataacacc tactacaacc cctccctcaa gaatcgagtc
      301 accttttcaa cagtcacgtc caagaaccag ttctccctta agctgagctc tgtgaccgcc
      361 gcggacacgg ccatgtatta ctgttcgagg gtgcgtggat acaactacat tttatttgac
      421 tcctggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007324             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18880:8174
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007324
VERSION     KCXD01007324.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18880:8174"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65806.1"
                     /translation="CATSSSGTWLYWCFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          119 a          139 c          135 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccata cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggagctgagc agtctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt gcttcgatat ctggggccct ggcaccccga tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007325             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17078:8793
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007325
VERSION     KCXD01007325.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17078:8793"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65807.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          115 c          157 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggcgga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc ggaacctatg
      241 gcatgcactg ggtccgccag gctccaggga agggcctgga gtgggtgacg gttatatcga
      301 atgatggaag taagaaatac tacgcggact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacgt gaaattggag gacacggccg
      421 tctattactg tgtgagagat gcgtttggta gcgggcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007326             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18698:10680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007326
VERSION     KCXD01007326.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18698:10680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..498
     V_segment       135..428
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65808.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       438..444
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..498
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          120 c          151 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 acaaaacaca gaacatacca tagtttgtgc tgagctgggt tttccttgtt gctcttttga
      121 aaggtgtcca gtgtgaggtg aagctggtgg agtctggggg cggcttggca aagcctgggg
      181 ggtccctgag actctcctgc gcagcctctg gattcagctt caattattac tacatgagct
      241 gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaat catggtgggg
      301 aaagtacata ctatgcagac tccgtgaagg gcagattcac cctctccaga gagaacgcca
      361 agaacacact atatcttcaa atggacagcc tgagaactga ggacacggct gtctattact
      421 gtgtgagaga tcgacgtgta cagtcgttat cctggttcga tgtctggggc ccgggagccc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007327             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14654:18980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007327
VERSION     KCXD01007327.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14654:18980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65809.1"
                     /translation="CASGGFEDDNGHYYTTLTFHEW"
     D_segment       423..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          113 a          140 c          147 g          104 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagt tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tcctgcaagg ctcctggata catcttcagc atatctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttggtgt aacagcctac
      301 gcacagaggt tccaggacag agtcacaatt accgcggaca cgtccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagtggcggc
      421 ttcgaggatg ataacggtca ctattatacg acactaacat ttcacgagtg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007328             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:26879:6659
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007328
VERSION     KCXD01007328.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:26879:6659"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65810.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       403..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           83 a          141 c          136 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcacgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg tagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcggttact ggtggggctg gatccgccag tccccaggaa aggggctgga
      241 gtggattggg tttttcggtg gttatggtgg gagcacctac tacaacccct ccctccagag
      301 tcgagtcacc atttcagccg acacgtccaa acaccagttc tccctgatac tgacctctgt
      361 gaccgccgcg gacacggccc tctactattg tgcgaggggg aatatagcag cgactggcat
      421 tgactactgg ggccagggac tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007329             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20886:9527
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007329
VERSION     KCXD01007329.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20886:9527"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..490
     V_segment       127..420
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65811.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       429..436
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          106 a          141 c          146 g           99 t
ORIGIN      
        1 acatgggggg catcacataa caaccacctc cctcctctaa agaagcccct gggaacacag
       61 ctcatcacca tggacctgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc
      121 cagtcccagg tccagctggt gcagtccggg gctgatgtga agaagcctgg ggcctcagtg
      181 aaactctcct gcaaggcttc tggattcgcc ttcagaatgt atgccctcag ttgggtgcga
      241 caggcccctg gacaagggct tgagtggatg ggagggatcg tcccgcttgt tggaacaaca
      301 aactccgcac agaagttcca gggcagagtc acgattaccg cggacacgtc cataagcaca
      361 gtctacatgg aactgagcag cctgagatct gaggacacgg ccgtgtatta ctgtgcgaga
      421 ggcctgggta gcagcgccca ctttggtttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01007330             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21878:19809
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007330
VERSION     KCXD01007330.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21878:19809"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65812.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          124 a          143 c          140 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagccac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaagttaaga agcctggggc ctcagtgatg
      181 gtctcctgcc aggtttccgg atacaccgtc accgaaatat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgctc ctgaaaaaaa tgagttaata
      301 cacgcagaca agttccagga cagagtcagc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtggcct gacatttgag gacacggccg tgtattactg tgcgacccac
      421 ggaggttata gcgacatctg gaactcccta tataacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007331             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:4176:11189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007331
VERSION     KCXD01007331.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:4176:11189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65813.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       411..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          107 a          145 c          135 g           93 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgatgc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattgt ccatgcactg ggtgcgacag
      241 gccccaggaa gaggccttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgacg
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggaactg
      361 agcagcctga gatctgagga cacggccgta tattactgtg cgatcggccc tagcggcagt
      421 tggaacgcct ggtccttcga tatctggggc cctgacaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01007332             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:17770:18400
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007332
VERSION     KCXD01007332.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:17770:18400"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65814.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       453..466
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..518
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          113 a          128 c          151 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgaactggg ttttccttgt
      121 tgctatctta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcacct tcgatgaata
      241 tggcttgagc tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatattag
      301 aagccaatac aggaattacg cgacagaata cgccgcatcg gtgaaaggca gattctccat
      361 ctccagagat gattcaaaga acacgcttta tctacaaatg agcagcctga caaccgagga
      421 cacggccgtc tattattgca ccaccctcta tggtggtagt tattacgtgg actactttga
      481 ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007333             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:16569:20575
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007333
VERSION     KCXD01007333.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:16569:20575"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65815.1"
                     /translation="CARGTTHLETAAGIGDYFDSW"
     D_segment       434..445
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          147 c          145 g           94 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cggctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttccggata caccttcagc atccatggca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttgattt aacacactac
      301 gcacagaagt tccagggcag agtcacaatt accgcggaca cgcccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagggaca
      421 acccacctcg agacggcagc tggaatcgga gactactttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007334             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:16736:14534
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007334
VERSION     KCXD01007334.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:16736:14534"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..435
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65816.1"
                     /translation="CAKGGSSSFYWYFDIW"
     D_segment       441..448
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..505
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          109 a          130 c          150 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctggct tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caggtggagg agtctggggg cggcttggca
      181 aagcctgggg gatccctgag actctcctgt gcagcctctg gattcacctt cagtacctat
      241 gctatgcatt gggtccgcca ggctccaggg aaggggctga aatgggtctc atctattagt
      301 agtggtggtc tcacatacta cgcagactcc gtgaagggcc gatttgccat ctccagagac
      361 aactcaaaga acacgctctc cctgcaaatg aacagcctga gcgctgagga cacggccgta
      421 tattactgtg cgaaaggagg tagcagctct ttctattggt acttcgatat ctggggccct
      481 ggcaccccag tgaccatctc ctcagcc
//
LOCUS       KCXD01007335             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6037:15077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007335
VERSION     KCXD01007335.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6037:15077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..473
     V_segment       113..406
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65817.1"
                     /translation="CARDESSINYPFDYW"
     D_segment       421..427
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           97 a          139 c          132 g          107 t
ORIGIN      
        1 acatggggga catgggaaat gctctctgag agtcacggac atcctgtgca agaacatgaa
       61 gtatctgtgg ttcttcctcc tcctggtgac agctcccaga tgggtcctgt cccaggtgca
      121 acttcaggag tcgggcccag gacaggtgag gccttcggag accctgtccc tcacctgcgc
      181 tgtctctcgt ggctccatca gtggttacag gtggagctgg atccgccagc ccccagggaa
      241 gggactggag tggattggac gcatctctgg tagtggtggg agtaccacct acaacccctt
      301 cctcaagagt cgagtcacca tttcaacaga cacgtttaac aaccagttct ccctgaagct
      361 gaactctgtg accgccgcag acacggccgt ctatttctgt gcgagagatg agagctccat
      421 taactaccct tttgactact ggggccgggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007336             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:7464:3879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007336
VERSION     KCXD01007336.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:7464:3879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65818.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          107 a          124 c          155 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttactacta
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattgccgc
      301 tgatggggat agcacatact atgcagactc catgaaggcc agattcacta tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagcagagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg atcaccgtct cctcagcc
//
LOCUS       KCXD01007337             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10299:11432
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007337
VERSION     KCXD01007337.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10299:11432"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..498
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65819.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       443..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>502
                     /gene="IGHG"
BASE COUNT          110 a          115 c          154 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agtctctgga ttcaccttca ggaattatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgtt
      301 tgatggaatt aagagttatt acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattcaaag aacatgctaa atcttcaaat gaacgacctg aaattggagg acacggccgt
      421 gtattactgt gcgagacgcc cttggaacgc tgactacttt gactactggg gccagggagt
      481 cctggtcacc gtctcctccg cc
//
LOCUS       KCXD01007338             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22069:12983
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007338
VERSION     KCXD01007338.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22069:12983"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65820.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          113 c          155 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg tagcctctgg attcaccttc agtagctatg
      241 gcataaactg ggtccgccag gctccaggga aggggctgga gtgggtggga attgtttcgt
      301 ttgatggaac taagagatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa gaatatgcta tatcttcaaa tgaacaacct gaaaatcgaa gacacggccg
      421 tgtattatag tacgagagta gactgtagtg gtggtgtctg ctactttgac cactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007339             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:17200:7912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007339
VERSION     KCXD01007339.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:17200:7912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65821.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       433..437
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          118 c          151 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttcctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggagtccct gagactctcc tgtgcagcct ctggattccc cttcagtacc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtctgtaagt tcgtctgatg
      301 aaagtaagaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaact
      361 ccaagaacat actatttctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 tctgtgtgag agatgccttc gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007340             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:29076:14584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007340
VERSION     KCXD01007340.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:29076:14584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..374
     V_segment       8..299
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65822.1"
                     /translation="CAKGRSGGVWPSSFDYW"
     D_segment       312..321
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       335..374
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           86 a           87 c          124 g           79 t
ORIGIN      
        1 acatggggag gtccagttgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt
       61 gaaggtctcc tgcaaggttt ccggagacac cttcagcgat ttatccatgc actgggtgcg
      121 acaggcccca ggaaaagggc ttgagtggat gggaagtgtt gatcctgtat atggtgaaat
      181 aattgtcgca gagaatttcc aggacagagt caccatgacc gaggacacgt ctacagacac
      241 agcctacata gagctgagca gcctggaatc tgaggacacg gccgtgtatt actgtgcgaa
      301 agggaggagt ggtggtgtct ggccgagctc cttcgactac tggggccagg gagtcctggt
      361 caccgtctcc tcagcc
//
LOCUS       KCXD01007341             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:21224:11584
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007341
VERSION     KCXD01007341.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:21224:11584"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..496
     V_segment       124..417
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65823.1"
                     /translation="CAKFSSWGDYYDYRGLDSW"
     D_segment       426..444
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT           97 a          144 c          139 g          118 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgagaa ggcccgggga gtctctgaag
      181 atctcctgtg agacctctgg atacagtttt aacacctact ggatcagctg ggtgcgccag
      241 atgcccggaa aaggcctgga gtggatgggg acgattgatc ctagtgattc tgataccaga
      301 tacagtccgt ccttccaagg ccaggtcacc atctcagccg acaagtccat cagtaccgcc
      361 tacctgcagt ggaacagcct gaaggcctcg gactccgcca cgtattactg tgccaaattt
      421 tcgtcctggg gtgattatta tgactatcgc ggtttggatt cctggggccg aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007342             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16554:4912
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007342
VERSION     KCXD01007342.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16554:4912"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..386
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65824.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       399..407
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           94 a          132 c          135 g           98 t
ORIGIN      
        1 acatggggga gagtcacgga catcctgtgc aagaacatga agcacctgtg gttcttcctc
       61 ctcctggtgg cagctcccag atgggtcctg tcccagctgc aggtgcagga gtcgggccca
      121 ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg tggctctatc
      181 agcagtagtt actgcagctg gatccgccag accccaggga agggactgga gtggattgga
      241 tacatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag tcgagtcacc
      301 ctgtcagtag acacgtccaa gaaccagtgc tccctgaagc tgagctctgt gaccgccgcg
      361 gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta cagcattgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007343             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18634:6875
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007343
VERSION     KCXD01007343.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18634:6875"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65825.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          115 a          111 c          153 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccaatcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtatgatg
      301 agactaagaa atactacgca gactctgtga gggaccgatt caccatctcc agagacaatt
      361 ccaaaaacat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgag agatgtcagg ggaacggggt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007344             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:23523:12531
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007344
VERSION     KCXD01007344.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:23523:12531"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65826.1"
                     /translation="CARSGDYGYYYDFDYW"
     D_segment       402..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          138 c          132 g          103 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcctcctcc tgctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcagtaactc ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattggac gtttctataa tagtggtggg aacaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagttct ccctgaagct gaactctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagatcgg gtgattacgg ttactattac
      421 gactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007345             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:24872:17649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007345
VERSION     KCXD01007345.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:24872:17649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65827.1"
                     /translation="CARDEDPSIFEYW"
     D_segment       409..413
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           93 a          134 c          130 g          104 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atccttgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gcgccatcag cagtggtttc tactggacct ggatccgcca acccccaggg aaggggctgg
      241 agtggattgg gtgtatcggt ggtaatagtg gtaccaccta ctacaagtcc tccctcaaga
      301 gtcgagccac catttcaaaa gacacgtcca acaatcaact ctccctgaag ttgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga tgaagacccc tccatttttg
      421 aatactgggg ccagggagtc ctggtcaccg tctcttcagc c
//
LOCUS       KCXD01007346             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:27427:7424
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007346
VERSION     KCXD01007346.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:27427:7424"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65828.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       447..452
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          109 a          119 c          161 g          114 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agccgggggg gtccctaaga ctctcctgtg cagcctctgg attcaccttc agtaggcact
      241 ggatgaactg ggtccgccag gctccaggaa aggggctgga gtgggtctca actattaata
      301 gtggtgggga caacacatat tacgcagact ccgtgaaggg ccgacttacc atttccagag
      361 acaactcaaa gaacacgctc ctcctgcaaa tgaacagcct gagagtggag gacacggccg
      421 tgtattactg tgttcaaggg gaaatttttg gagtgggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01007347             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:22949:15476
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007347
VERSION     KCXD01007347.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:22949:15476"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..487
     V_segment       121..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65829.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       420..426
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          112 a          141 c          138 g           98 t
ORIGIN      
        1 acatggggac acacaacagc cacatccctc ccctacagaa gccccagagc acagcacctc
       61 accatggact ggacctggag gatcctcctc ttggtggcag cagctgcagg cgcccgctct
      121 gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc
      181 tcctgcgagg tttccggata caccttcacc gaactgtcca tccactgggt gcgacaggcc
      241 cctggaaaag gccttgagtg gatgggaagt gttgatcctg aatatggtga aatgatagac
      301 gcagaaaagt tccagggcag agtcaccttg accgaggaca cgtctacagg aacggcctac
      361 atggagctga tcagcctgag atctgaagac acggccgtgt attactgtgc gacatcaccc
      421 agcggcaatt ggcttttttg gtacttcgat ttttggggcc ctggcacccc aatcaccatc
      481 tcctcagcc
//
LOCUS       KCXD01007348             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:20191:17032
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007348
VERSION     KCXD01007348.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:20191:17032"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..414
                     /gene="IGHV5-157"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65830.1"
                     /translation="CAKTYYSGSLEIW"
     D_segment       418..433
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..475
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          101 a          143 c          127 g          106 t
ORIGIN      
        1 acatgggggt ctccctcacc gcacagctgg gatctcagtt cttcatttct gtcctccacc
       61 acgatggggt caactgccat cctcgccctc ctcctggctg ttctccaagg agtctgtgcc
      121 gaggtgaaac tggtgcagtc tggggcagag gtgagaaggc ccggggagtc tctgaagatc
      181 tcctgtaaga cttctggata cagctttacc accaactgga tcagttgggt gcgccagacg
      241 cccggaaaag gcctggaatg gatggggacc atctatcctg ctgattctga ggccaaatac
      301 aacccgtcct tccaaggcca cgtcactatc tcagccgaca agtccatcag taccacctac
      361 ctgcagtgga gcagcctgaa ggcctcggac accgccacgt atttctgtgc gaaaacctac
      421 tatagtggta gtttggaaat ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007349             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:28685:15681
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007349
VERSION     KCXD01007349.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:28685:15681"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65831.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          114 c          153 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtacctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007350             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:8922:19743
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007350
VERSION     KCXD01007350.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:8922:19743"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65832.1"
                     /translation="CARDESAWNYVFDYW"
     D_segment       406..412
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          136 c          135 g          103 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtccagtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcagagac cctgtccctc atctgcgctg tctctggtgg
      181 ctccatcagt actcactggt ggagctggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctccggta gtggtgggag caccaggtat aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga gttctgtgac
      361 cgccgcggac acggccgtgt attattgtgc gagagatgag tccgcctgga attacgtctt
      421 tgactactgg ggccagggag tcctggccac cgtctcctca gcc
//
LOCUS       KCXD01007351             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:27246:11649
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007351
VERSION     KCXD01007351.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:27246:11649"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..476
     V_segment       102..409
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65833.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       416..425
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>482
                     /gene="IGHG"
BASE COUNT           82 a          142 c          143 g          115 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcac ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtctgt cacctgcgct gtctctggtg
      181 gctctatcag cagtaccaac tggagctgga tccgccaggc cccagggaag ggactggagt
      241 ggattgggtg tatctttggt ggtggtatct ttggtggtgg aagtaacacc ttctacagcc
      301 cttccctcaa gagtcgagtc accctgtcag tggacgcgtc caagacccag ctctccctga
      361 agctgacgtc tgtgaccgcc gcggacacgg ccgtgtattt ctgtgcgagc gctgatagtg
      421 gttatcctcc ctacttcttt gacatctggg gccagggagt cctggtcacc gtctccccag
      481 cc
//
LOCUS       KCXD01007352             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:22227:10949
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007352
VERSION     KCXD01007352.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:22227:10949"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65834.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       444..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          105 a          115 c          159 g          122 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggtttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtatctct
      241 ggcatgcact gggtccgcca ggctccaggg caggggctgg attgggtggc agttgaatcg
      301 tttgatggag gtaagaaata ctacgctgac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgagcaacc tgaaattgga ggacacggcc
      421 gtgtattact gtgtgagaga tgcctacggg ggcggtttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01007353             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:16031:15305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007353
VERSION     KCXD01007353.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:16031:15305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65835.1"
                     /translation="CARDAFGSGCDFW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          118 c          151 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtaattttg
      241 gcatccactg ggtccgccag gctccaggga agggcctgga gtgggtggca gttatatcgt
      301 ctgatgaaag taagaaatac tatgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggtt tatcttcaga tgaacaacct gaagttggac gacacggccg
      421 tctattactg tgcgagagac gcatttggca gcggctgtga cttctggtgc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007354             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:22575:1852
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007354
VERSION     KCXD01007354.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:22575:1852"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..449
     V_segment       104..390
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <383..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65836.1"
                     /translation="CASSDYGWFDVW"
     D_segment       395..403
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       405..449
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           94 a          123 c          127 g          107 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 atcggaccca ggagtagtga agccttcgga gaccctgtcc ctcacctgcg ttgtctctgg
      181 tggcgatagt tataggtgga gctggatccg ccagccccca gggaagggac tggaatggat
      241 tgggtatatt tatggtagta ttacggacac caactacaac ccctccctca aaagtcgagt
      301 caccatttca aaagacacgt ccaagaagca gttctccttg aaactgagct ctgtgaccgt
      361 cgcggacacg gccgtgtatt tctgtgcgag ttcagactac ggttggttcg atgtctgggg
      421 cccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007355             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:25654:3587
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007355
VERSION     KCXD01007355.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:25654:3587"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65837.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       426..433
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          139 c          152 g           99 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg agacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgacc ctgcaaatgg tgaaataata
      301 cacgcagata gtttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gagatctgag gacacggccg tgtattactg tgcgagaggg
      421 gggttcggta gcagtgtctg gtccaatctc gtctatggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007356             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13319:4824
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007356
VERSION     KCXD01007356.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13319:4824"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..426
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65838.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       442..449
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          120 c          145 g          128 t
ORIGIN      
        1 acatggggct gggagaggag cccagccctg ggattcccag gtgttttcat tcagagatca
       61 ggactgaaca cacaggactc accatggagt ttatgctgag ctgggttttc cttgtttcta
      121 tattaaaagg tgtccagtgt gtggagcatc tggtggagtc tgggggaggc ttggtacagc
      181 ctggggcgtc cctgagactc tcctgtgcag cctctgaatt caccttcagt gcctatgaca
      241 tgcactgggt tcgccaggct ccagggaagg gtctagaatg ggtatcaggt attaacattg
      301 gcggtgaccc atactaccca gactctgtga agggtcgatt caccatctcc agagacaatg
      361 ccaagaactc cttgtatctt caaatgaaca acctgagagc tgaggacact gctgtgtatt
      421 attgtgtgag ggggatggat aactaccact acagtaatac ggactttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007357             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18687:9611
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007357
VERSION     KCXD01007357.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18687:9611"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    133..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        133..499
     V_segment       133..418
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <415..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65839.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       434..441
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          121 c          140 g          127 t
ORIGIN      
        1 acatgggggg agcccagccc tgggattccc aggtgttttc attcagagat caggactgaa
       61 cacacaggac tcaccatgga gtttatgctg agctgggttt tccttgtttc tatattaaaa
      121 ggtgtccagt gtgtggagca tctggtggag tctgggggag gcttggtaca gcctggggcg
      181 tccctgagac tctcctgtgc agcctctgaa ttcaccttca gtggctatga catgcactgg
      241 gttcgccagg ctccagggaa gggtctagaa tggctatcag gtattaacat tggcggtgac
      301 ccatactacc cagactctgt gaagggtcga ttcaccatct ccagagacaa cgccaagaac
      361 tccttgtatc ttcaaatgaa caacctgaga cctgaggaca ctgctgtgta ttattgtgtg
      421 agggggatgg ataactacca cttcagtaat acggactttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007358             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:21183:4754
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007358
VERSION     KCXD01007358.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:21183:4754"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65840.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          114 c          148 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggattgggt ggcagttatg tcgtttgatg
      301 aaaatgtgaa gttctacgca gattctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccctgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007359             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:12187:12705
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007359
VERSION     KCXD01007359.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:12187:12705"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65841.1"
                     /translation="CARYEDEYSDYHFDYW"
     D_segment       405..420
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           91 a          140 c          133 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc tgctcccaga tgggtcctgt cccagctgca tctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcaatagcta ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt ctatctatgg tggtactggg agcgccggct acaacccctc cctcaagagt
      301 cgagtcaccg tttcaacaga cacgtccaag aaccagtttt ccctgaagct gacgtctgcg
      361 accgccgcgg acaccgccgt gtattactgt gcgagatatg aggatgaata cagtgactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007360             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:15043:17606
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007360
VERSION     KCXD01007360.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:15043:17606"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65842.1"
                     /translation="CGRDVWGTGLDYW"
     D_segment       445..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          111 a          117 c          157 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctatttcaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcagctt cagtaccttt
      241 ggcatgcact gggtccgcca ggctccaggg aagggactgg agtgggtggc agttatatcg
      301 catgatttaa ctaaggagta ctacgcagac tctgtgaagg accgattcac catctccaga
      361 gacaactcca agaacatggt atatcttcaa atgaacaacc tgaaatcgga ggacacggcc
      421 gtgtattact gtgggagaga tgtttggggg accggacttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007361             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:17676:4680
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007361
VERSION     KCXD01007361.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:17676:4680"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..512
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65843.1"
                     /translation="CSREWIQWAQLVSGLDSW"
     D_segment       439..460
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       466..512
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          116 a          121 c          159 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccaggc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttggtctg acctgggttt tccttgttgg
      121 tattttgaaa ggtgtccagt gtgaggtgca gctggtggag tctggaggag ccttggctca
      181 gcctgggggg tccctgagac tctcctgtgc agcgtctggg ttcaccttca gtagctatgc
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ccatatcatt
      301 tgatggaagt aagaaaaact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caactccaac aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atactactgt tcgagggagt ggatacagtg ggcacagtta gtgagcggtt tggattcctg
      481 gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007362             520 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12360:19191
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007362
VERSION     KCXD01007362.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12360:19191"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..518
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..518
     V_segment       146..445
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>487
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65844.1"
                     /translation="CVRLQSSHYYTFGFHSW"
     D_segment       459..468
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       480..518
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        519..>520
                     /gene="IGHG"
BASE COUNT          115 a          129 c          148 g          128 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt cccaggcgtc tccacttggt
       61 gatcagctct gaacacaaga gactcaccat ggaatttgta ctgagctggg ttttccttgt
      121 tgctatttta aaaggtgtcc agtgtgacgt gcagctggta gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga ggctctcctg tgcagcctct ggattcacct tcagtgacta
      241 tggcatgagc tgggtccgcc aggcttctgg gcaaggactg gagtgggttg gctatattag
      301 aagcaaatct aacaattacg cgacagaata cgccgcatcg gtgaaaggca ggttcgccat
      361 ctccagagat gattcaaaga atacgctata tctgcaaatg agcagtctga aaaccgagga
      421 cacggccgtc tattactgtg tgagactcca gtccagtcac tattacactt tcggtttcca
      481 ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007363             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14788:11519
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007363
VERSION     KCXD01007363.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14788:11519"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65845.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          113 a          141 c          131 g           96 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagttggtac agtctggggt tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga gaaggacttg agtggatggg aggtgttcat cctgaatttg gtaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg acttctgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01007364             293 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:12977:15515
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007364
VERSION     KCXD01007364.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 293)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 293)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:12977:15515"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    2..291
                     /note="immunoglobulin heavy chain variable region"
     V_region        2..291
     V_segment       2..212
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <204..>260
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65846.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       219..236
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       241..291
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        292..>293
                     /gene="IGHG"
BASE COUNT           67 a           82 c           82 g           62 t
ORIGIN      
        1 acatgggcgg ttactactgg agctggatcc gccagccccc agggaagggg ctggagtgga
       61 ttggatatat cagtgctagt agtgggacca ccgactacaa cccctccctc aagagtcgag
      121 tcaccatttc aagagacacg tccaagaacc tcttctccct gaacctgagc tctgtgaccg
      181 ccgcggacac ggccgtgtat tactgtgcga gagagaaata ctatagtggt agttataaac
      241 acaactggtt cgatgtctgg ggcccgggag tcctggtcgc cgtctcctca gcc
//
LOCUS       KCXD01007365             371 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:25186:20777
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007365
VERSION     KCXD01007365.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 371)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 371)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:25186:20777"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..369
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..369
     V_segment       8..289
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <288..>338
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65847.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       304..318
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       322..369
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        370..>371
                     /gene="IGHG"
BASE COUNT           84 a           94 c          103 g           90 t
ORIGIN      
        1 acatgggggt ggagtctggg ggaggcttgg tccagcctgg cgggtccctg agactctcct
       61 gtgcagcctc tggattcacc ttcagtgact atgccctgag ctgggtccgc caggcttctg
      121 ggaaaggact ggagtggatt ggctatatta gaagccaata taacaatttc gcgacagaat
      181 acgccccatc ggtgaaaggc agattcgcca tctccagaga tgattcaaag aacacgctat
      241 ttctgcaaat gagtagcctg aaaaccgagg acacggccgt gtattactgc accacccatt
      301 ttggtggtaa ttattacttg gactactttg tctactgggg ccagggagtc ctggtcaccg
      361 tctcctcagc c
//
LOCUS       KCXD01007366             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:11863:20826
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007366
VERSION     KCXD01007366.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:11863:20826"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..494
     V_segment       140..428
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65848.1"
                     /translation="CVAGRRHVDLDYW"
     D_segment       439..444
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          102 a          125 c          154 g          115 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacaca ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccattgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctaagactct cctgtgaagc ctccgggttc accttcagtg accactgcat
      241 acactgggtc cgccaggctt cagggaaggg gctggagtgg gtctcaggta ttacttatac
      301 tggtgttacc acatggtacg cagactccgt gaggggcaga ttcaccatct ccagagagaa
      361 caccaagaac acactgtatc ttcaaatgga cagcctgaga gctgaggaca cggctgtcta
      421 tttctgtgtg gcaggaaggc ggcacgtgga ccttgactac tggggccagg gagtcctggt
      481 cgccgtctcc tcagcc
//
LOCUS       KCXD01007367             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:16852:14429
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007367
VERSION     KCXD01007367.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:16852:14429"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..493
     V_segment       127..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <412..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65849.1"
                     /translation="CATSSSGTWLYWYFDLW"
     D_segment       432..438
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..493
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          123 a          144 c          133 g           95 t
ORIGIN      
        1 acatggggag agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgagg tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 aaggtctcct gcaaggtttc cggatacatc ttaaccgaat tatccataca ctgggtgcga
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctcaata tggtgaaatg
      301 atagacgccg agaaattcca gggcagagtc accatgaccg aggacacgtc tacagacaca
      361 gcctacatgg aactgagcag tctgagatcc gaggacacgg ccgtatatta ctgtgcgaca
      421 tcatccagcg gcacctggct atactggtac ttcgatctct ggggccctgg ctccccaatc
      481 accatctcct cagcc
//
LOCUS       KCXD01007368             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12490:3247
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007368
VERSION     KCXD01007368.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12490:3247"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..484
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65850.1"
                     /translation="CARHRTSDYYSGSYPNPFRSFDFW"
     D_segment       408..427
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..484
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>490
                     /gene="IGHG"
BASE COUNT           96 a          150 c          137 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggagaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtac atcaatggtg ctagtgggag caccacccac aacccgtccc tccagagtcg
      301 agtcaccatt tccattgaca cgtccgagaa ccagttctcc ctgaggctga actctataac
      361 cgccgcggac acggccgtgt attactgtgc gagacatagg acgtcggatt actatagtgg
      421 cagttatcca aaccccttcc gctcctttga cttctggggc cagggagtcc tggtcaccgt
      481 ctccccagcc
//
LOCUS       KCXD01007369             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:19349:12339
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007369
VERSION     KCXD01007369.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:19349:12339"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..467
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65851.1"
                     /translation="CARKLPGLQLTGFDSW"
     D_segment       413..418
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..467
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           91 a          142 c          132 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggggtc
      121 gggcccaggg ctggtgaagc cttcggagac cctgtccctc acctgcgctg tttctggtga
      181 ctccatcaac agtggctact actggagttg gatccgccaa cccccaggga gggggctgga
      241 gtggattggg tctatcggtg gtagtagtgg cagcacctac tacaacccct ccctcaagag
      301 tcgagtcacc ctttcaaaag acacgtccag gaaccagttc tccctgaaac tgagctctgt
      361 gaccgccgca gacacggccg tttattactg tgcgagaaaa cttccaggtc tccaactaac
      421 cggtttcgat tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007370             464 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:4690:11488
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007370
VERSION     KCXD01007370.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:4690:11488"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..462
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>431
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65852.1"
                     /translation="CARVRGVTIHYFDYW"
     D_segment       405..412
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>464
                     /gene="IGHG"
BASE COUNT           87 a          139 c          138 g          100 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtggaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcac ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcggt gtctctggtg
      181 gctccttcag cggttactac tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattggcta tatcagtggg agtagtggga gcaccgacta caagtcctcc ctcaacagtc
      301 gagtcaccat ttcaacagac acgtccaaga accagttctc cctgaggctg aactctgtga
      361 ccgccgcgga cacggccgtg tattactgtg cgagagtccg gggcgttact atccactact
      421 ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007371             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:15207:3015
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007371
VERSION     KCXD01007371.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:15207:3015"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65853.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       443..449
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          115 a          110 c          154 g          118 t
ORIGIN      
        1 acatgggggc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcacc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgaag cctctggatt caccttcagt agttatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atatcgtatg
      301 atgtaagtaa gaaatactac gcagacgctg tgaaggaccg attcaccatt tccagagaca
      361 attccaagaa cacgctatat cttcaaatga acaacctgaa attggaggac acggccgtgt
      421 attactgtgg gagagatgat aatggggtgc ttatcgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007372             366 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:28892:12405
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007372
VERSION     KCXD01007372.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 366)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 366)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:28892:12405"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    188..364
                     /note="immunoglobulin heavy chain variable region"
     V_region        188..364
     V_segment       188..285
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <277..>333
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65854.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       295..306
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       323..364
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        365..>366
                     /gene="IGHG"
BASE COUNT           65 a          116 c          107 g           78 t
ORIGIN      
        1 acatggggga gtctccctca ccgcacagct gggatctcag tgcttccttt tctgtcctcc
       61 accacgatgg ggtcaactgc catcctcacc ctcctactgg ctgttctcca aggagtctgt
      121 gccgaggtgc agctggtgca gtctggagca gaggtgaaaa ggcccgggga gtctctgaag
      181 atctcctgcc aggtctccat ctcagccgac aagtccatca gcaccgccta cctgcagtgg
      241 agcagcctga aggcctcgga caccgccacg tattactgtg cgaaaggggg gtggtggggt
      301 gattatccac cctcagactg gctcgatgtc tggggcccgg gagtcctggt caccgtctcc
      361 tcagcc
//
LOCUS       KCXD01007373             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:4194:11708
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007373
VERSION     KCXD01007373.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:4194:11708"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65855.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       423..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          119 a          144 c          132 g           97 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgatttat ccatacactg gatacgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacgcagaga agttccaggg cagagtcacc atgaccgagg acacgtctac acatacagcc
      361 ttcatggaat tgagcagcct gaaatctgac gacacggccg tatatttctg tgcgagtggg
      421 cctagcggca cctggatcga ctggtccttc gatgtctggg gccctggcac cccaatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01007374             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:24068:12010
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007374
VERSION     KCXD01007374.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:24068:12010"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..446
     V_segment       101..387
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <380..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65856.1"
                     /translation="CASSDYGWFDVW"
     D_segment       392..400
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..446
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           92 a          123 c          127 g          106 t
ORIGIN      
        1 acatgggggt tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggaatc
      121 ggacccagga gtagtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtgg
      181 cgatagttat aggtggagct ggatccgcca gcccccaggg aagggactgg aatggattgg
      241 gtatatttat ggtagtatta cggacaccaa ctacaacccc tccctcaaaa gtcgagtcac
      301 catttcaaaa gacacgtcca agaagcagtt ctccttgaaa ctgagctctg tgaccgtcgc
      361 ggacacggcc gtgtatttct gtgcgagttc agactacggt tggttcgatg tctggggccc
      421 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007375             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:7978:13152
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007375
VERSION     KCXD01007375.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:7978:13152"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65857.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       406..414
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          133 c          135 g          104 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagg tgcaggagtc
      121 gggcccagga ctggtgaagc ctccggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctctatcagc agtagttact gcagctggat ccgccagacc ccagggaagg gactggagtg
      241 gattggatat atctatggga gtgatagtag taccaactac aacccctccc tcaagagtcg
      301 agtcaccctg tcagtagaca cgtccaagaa ccagtgctcc ctgaagctga gctctgttac
      361 cgccgcggac acggccgtgt attattgtgc gagttcgggt atagaagtgg ttgcctacag
      421 cattgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007376             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18138:5038
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007376
VERSION     KCXD01007376.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18138:5038"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..392
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65858.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       401..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           80 a          139 c          140 g          102 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggta gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctggccct cacctgcgct gtctctggtg
      181 gctccatcag tggttactgg tggggctgga tccgccagtc cccagggagg gggctggaat
      241 ggattggatt tttcggtggt agtggtggga acacctacta caagtcctcc ctccagagtc
      301 gagtcaccat ttcagccgac ccgtccaaga accagttctc cctgatactg acctctgtga
      361 ccgccgcgga cacggccctc tattactgtg cgcgggggaa tatagcagcg actggcattg
      421 actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007377             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19342:20280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007377
VERSION     KCXD01007377.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19342:20280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65859.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          121 a          139 c          133 g           94 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca tcttaaccga attatccatg cactgggtgc gacaggcccc
      241 tggagaaggg cttgagtgga tgggaagtgt tgatcctcaa tatggtgaaa tgatagacgc
      301 agagaaattc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      361 ggaactgagc agtctgagat ctgaggacac ggccgtatat tactgtgcga catcatccag
      421 cggcacctgg ctatactggt acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007378             510 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:20049:5556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007378
VERSION     KCXD01007378.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 510)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 510)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:20049:5556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..508
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..508
     V_segment       142..427
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>477
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65860.1"
                     /translation="CVRGMDNYHYVNTDFDYW"
     D_segment       443..450
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..508
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        509..>510
                     /gene="IGHG"
BASE COUNT          112 a          117 c          148 g          133 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct gggattccca ggtgttttca ttcagagatc
       61 aggactgaac acacaggact caccatggag tttatgctga gctgggtttt ccttgtttct
      121 atattaaaag gtgtccagtg tgtggagcat ctggtggagt ctgggggagg cttggtacag
      181 cctggggcgt ccctgagact ctcatgtgta gcctctgaat tcaccttcag tggctatgac
      241 atgcactggg ttcgccaggc tccagggaag ggtctggagt gggtttcagg tgttaacatt
      301 ggcgatgacc cattctaccc agactctgtg aagggtcgat tcaccatctc cagagacaat
      361 gccaagaact ccttgtatct tcaaatgaac aacctgagag ctgaggacac tgctgtgtat
      421 tattgtgtga gggggatgga taactaccac tacgttaata cggactttga ctactggggc
      481 cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007379             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12407:6728
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007379
VERSION     KCXD01007379.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12407:6728"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65861.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          112 c          152 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccatttg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gtcgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagaaac tttggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggctgttatc tcgtatgatg
      301 aaaataccaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaatat gctatatctt caaatgaaca acctgaaatt gggggacacg gccgtgtatt
      421 attgtgtgcg agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007380             422 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:16073:19879
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007380
VERSION     KCXD01007380.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 422)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 422)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:16073:19879"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    66..420
                     /note="immunoglobulin heavy chain variable region"
     V_region        66..420
     V_segment       66..359
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <351..>389
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65862.1"
                     /translation="CVGGRRHVDLDYW"
     D_segment       365..370
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       379..420
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        421..>422
                     /gene="IGHG"
BASE COUNT           83 a          102 c          134 g          103 t
ORIGIN      
        1 acatggggat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg aaaggtgtcc
       61 attgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg gggtccctaa
      121 gactctcctg tgcagcctcc ggattcacct tcagtgacca ctgcatgcac tgggtccgcc
      181 aggcttcagg gaaggggctg gaatgggtct caggtattac ttatactggt gttaccacat
      241 ggtacgcaga ctccgtgagg ggcagattca ccatctccag agagaacgcc aagaacacac
      301 tatatcttca aatggacagc ctgagtactg aggacacggc tgtctatttc tgtgtgggag
      361 gaaggcggca cgtggacctt gactactggg gccagggagt cctggtcacc gtctcctcag
      421 cc
//
LOCUS       KCXD01007381             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:14307:13943
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007381
VERSION     KCXD01007381.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:14307:13943"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    199..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        199..441
     V_segment       199..352
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <346..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65863.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       361..383
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>447
                     /gene="IGHG"
BASE COUNT          102 a          121 c          127 g           97 t
ORIGIN      
        1 acatggggga tcacataaca accacgtccc tcctctaaag aagcccctgg gaacacagct
       61 catcaccatg gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca
      121 gtcccaggtc cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 gctctcctgc aagacttctg gatgggaggg atcatccctc ttgttggtgt gacaaactac
      241 gaacagaagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      301 atggaactga gcagcctgag atctgaggac acggccgtct actattgtgc gacaggggta
      361 tattaccagg atgaatacgg ttatttttat gtcggcggtg actttgacta ctggggccag
      421 ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01007382             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:20969:16240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007382
VERSION     KCXD01007382.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:20969:16240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65864.1"
                     /translation="CATGPSGTWNAWYLEIW"
     D_segment       416..426
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          143 c          134 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaggg
      181 tctcctgcaa ggtttccgga tacaccttca ccgatttatc catacactgg gtgcggcagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tctatatggt gaaatgaagt
      301 tccagggcag agtcaccatg accgaggaca tgtctgcaga cacagcctac atggaactga
      361 gtagcctgac atctgacgac acggccgtgt attactgtgc gactggccct agcggcacct
      421 ggaacgcctg gtacctcgaa atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007383             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:24660:18197
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007383
VERSION     KCXD01007383.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:24660:18197"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65865.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       424..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          113 a          136 c          138 g          100 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca ggtacaggcg cccactctga
      121 ggtccagctg gtgcagtcgg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgtaaggtt tccggataca ccttcaccga attatccatg cactgggtgc gacaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctgtt tttggtgaaa taatgaattc
      301 agagaagttc cagggcagag tcgccttgac cgaggacacg tctacagaca cagcctacat
      361 ggagttgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcga catcatccag
      421 cggcacctgg ctatattggt acttcgatgt ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007384             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:26343:19563
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007384
VERSION     KCXD01007384.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:26343:19563"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..468
     V_segment       89..380
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65866.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       390..415
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>472
                     /gene="IGHG"
BASE COUNT          106 a          126 c          141 g           99 t
ORIGIN      
        1 acatggggcc ctgggaacac agctcatcac catggacttg acctggaggc tcctctttgt
       61 ggtggcagca gctacaggtg cccagtccca ggtccagctg gtgcagtccg gggctgaggt
      121 gaagaagcct ggggcctcag tgaagctctc ctgcaaggct tctggattca cgttcagcac
      181 cgatgccatc agttgggtgc gacaggcccc tggacaaggg cttgattgga tgggaggggt
      241 catccctctt atgggtacaa caaactacgc acagaagttc cagggcagag tcacgtttac
      301 cgcggacacg tcactaagca cagcctacat ggaactgagc agcctgagat ctgaggacac
      361 ggccgtgtat tattgtgcga aatccgtgaa ttacgaggaa gataacggtt actatatacc
      421 gacgcagttt gactactggg gccagggagt cctggtcacc gtctcctctg cc
//
LOCUS       KCXD01007385             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:13160:15158
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007385
VERSION     KCXD01007385.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:13160:15158"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65867.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       418..424
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          111 a          140 c          138 g           98 t
ORIGIN      
        1 acatggggac acaacagcca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctgcaggcg cccgctctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcgaggtt tccggataca ccttcaccga actgtccatc cactgggtgc gacaggcccc
      241 tggaaaaggc cttgagtgga tgggaagtgt tgatcctgaa tatggtgaaa tgatagacgc
      301 agaaaagttc cagggcagag tcaccttgac cgaggacacg tctacaggaa cggcctacat
      361 ggagctgatc agcctgagat ctgaagacac ggccgtgtat tactgtgcga catcacccag
      421 cggcaattgg cttttttggt acttcgattt ttggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007386             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:13329:11115
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007386
VERSION     KCXD01007386.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:13329:11115"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65868.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          108 c          154 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt attgctattt
      121 taagaggtgt ccagtgtgag gtgcacctgg tggagtctgg gggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcat gttcagtaac tatggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gtcagttata tcgtatgatg
      301 taactgtgaa atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaatac ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgtgag agatgtcagg ggaacggggt ttgacttctg gggccaggga gtcctggtca
      481 ccgtctcgtc agcc
//
LOCUS       KCXD01007387             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23619:8776
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007387
VERSION     KCXD01007387.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23619:8776"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65869.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          104 a          126 c          154 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttaat ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtctta acgctggtgg
      301 ggataccacc tactatgcag actccgtgaa gggcagatcc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007388             362 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:24373:13842
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007388
VERSION     KCXD01007388.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 362)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 362)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:24373:13842"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..356
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..356
     V_segment       5..267
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>329
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65870.1"
                     /translation="CATGVYYQDEYGYFYVGGDFDYW"
     D_segment       276..298
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..356
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        357..>362
                     /gene="IGHG"
BASE COUNT           82 a           91 c          107 g           82 t
ORIGIN      
        1 acatggggaa gaggcctggg gcctcagtga agctctcctg caaggcttct ggatacacct
       61 tcagcatctc tgccatcagt tgggtgcgac aggcccctgg acaaggactt gggtggatgg
      121 gagggatcat ccctcttgtt ggtatgacaa actacgaaca gaagttccag ggcagagtca
      181 cgattaccgc ggacacgtcc acgaatacag tcttcatgga actgagcagc ctgagatctg
      241 aggacacggc cgtctactat tgtgcgacag gggtatatta ccaggatgaa tacggttatt
      301 tttatgtcgg cggtgacttt gactactggg gccagggagt cctggtcacc gtctccccag
      361 cc
//
LOCUS       KCXD01007389             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:13306:13103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007389
VERSION     KCXD01007389.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:13306:13103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65871.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       428..435
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          143 c          152 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 gctctgaggt ccaactggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacacct tcaccgactt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga ccctgcaaat ggtgaaataa
      301 tacacgcaga tagtttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcggc ctgcgatctg aggacacggc cgtttattac tgtgcgagag
      421 ggggcttcgg tagcagtgtc tggtccaatc tcgtctatgg tttggattcc tggggccaag
      481 gggtcgccgt caccgtctcc tcagcc
//
LOCUS       KCXD01007390             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:4969:8729
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007390
VERSION     KCXD01007390.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:4969:8729"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..500
     V_segment       121..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65872.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       422..447
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>504
                     /gene="IGHG"
BASE COUNT          120 a          141 c          141 g          102 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gcggtggcag cagctacagg tgcccagtcc
      121 caggtccaac tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctgggtt cacctttagc accgaagcca tcaattgggt gcgacaggcc
      241 cctggacaag gacttgactg gatgggaggg gtcatccctc ttatgggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgttt accgcggaca cgtccataag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt attattgtgc caaatccgtg
      421 aattacgagg aagataacgg ttactatata ccgacgcagt ttgactactg gggccaggga
      481 gtcctggtca ccgtctcctc tgcc
//
LOCUS       KCXD01007391             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19722:14965
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007391
VERSION     KCXD01007391.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19722:14965"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    83..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        83..437
     V_segment       83..376
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <368..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65873.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       386..391
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       395..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT          100 a           95 c          134 g          110 t
ORIGIN      
        1 acatggggaa gacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
       61 tactttaaga ggtgtccagt gtgacgtgca actggtggag tctggaggag gcttggttca
      121 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagttttgg
      181 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      241 tgatgaaact aagaaatatt acgcagactc tgtgaaggac cgattcaccc tctccagaga
      301 caattccaag aatatgctat atcttcaaat gaacaacctg aaactggagg acacggccgt
      361 gtatttctgt gtgagagatg ttaggggaac ggggtttgac tactggggcc agggagtcct
      421 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007392             359 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15995:4289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007392
VERSION     KCXD01007392.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 359)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 359)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15995:4289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..357
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..357
     V_segment       1..284
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <276..>326
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65874.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       294..314
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       316..357
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        358..>359
                     /gene="IGHG"
BASE COUNT           70 a          112 c           98 g           79 t
ORIGIN      
        1 tgcaggagtc gggcccaggc ctggtgaagc cttcggagac cctgtccctc acctgcgctg
       61 tctctggtgg ctccatcacc agtagcttct ggaactggat ccgccagccc ccagggaagg
      121 gactggagtg gattgggtct atctatggtg ctactgggag caccacctac aacccctccc
      181 tcaagagtcg agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgagactga
      241 gctctgtgac cgccgcggac accgccgtgt attactgtgc gagatatgac gacgatgatt
      301 acggttccta ttaccttgac tactggggcc agggagtcct ggtccccgtc tcgtcagcc
//
LOCUS       KCXD01007393             444 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:4748:15732
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007393
VERSION     KCXD01007393.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 444)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 444)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:4748:15732"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    88..442
                     /note="immunoglobulin heavy chain variable region"
     V_region        88..442
     V_segment       88..381
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <373..>411
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65875.1"
                     /translation="CARDDMGTGFDYW"
     D_segment       382..387
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       400..442
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        443..>444
                     /gene="IGHG"
BASE COUNT          102 a           98 c          134 g          110 t
ORIGIN      
        1 acatggggca cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt
       61 gttgctattt taagaggtgt tcggtgtgag gtgcaactgg tggagtctgg agggggcttg
      121 gttcagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac
      181 tttggcatac actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt
      241 tcatctgatg gaagtaagaa atactacgca aactctgtga aggaccgatt caccatctcc
      301 agagacaatt ccaagaacat agtatatctt caaatgaaca gcctgaaatt ggaggacacg
      361 gccgtctatt actgtgcgag agatgatatg gggaccggtt ttgactactg gggccaggga
      421 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007394             301 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:13268:5235
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007394
VERSION     KCXD01007394.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 301)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 301)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:13268:5235"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..299
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..299
     V_segment       8..226
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <218..>268
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65876.1"
                     /translation="CARVGEGSGGAEDFDYW"
     D_segment       236..244
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       255..299
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        300..>301
                     /gene="IGHG"
BASE COUNT           76 a           67 c           90 g           68 t
ORIGIN      
        1 acatggggga ttcaccttca gtagctttgg catgcactgg gtccgccagg ctccagggaa
       61 gggactggag tgggaggcac ttatatctaa tgatggaagt aagaaatatt acgcagactc
      121 cgtgaaggac cgattcacca tctccagaga caattccaag aacatgctgt atcttcaaat
      181 gaacaacctg aaattggatg acacggccgt gtattactgt gcgcgagttg gagagggtag
      241 tggtggtgcg gaggactttg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      301 c
//
LOCUS       KCXD01007395             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:14045:19025
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007395
VERSION     KCXD01007395.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:14045:19025"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..450
     V_segment       87..379
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65877.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       392..400
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           91 a          129 c          133 g           99 t
ORIGIN      
        1 acatgggcac ggacatcctg tgcaagaaca tgaagcacct gtggttcttc ctcctcctgg
       61 tggcagctcc cagatgggtc ctgtcccagc tgcagctgca ggagtcgggc ccagggctgg
      121 tgaagcctcc ggagaccctg tccctcacct gcgctgtctc tggtggctct atcagcagta
      181 gttactggag ctggatccgc cagaccccag ggaagggact ggagtggatt gggtatatcc
      241 atgggagtga tagtagtacc aagtacaacc cctccctcaa gagtcgagtc accctgtcag
      301 tagacacgtc caagaatcaa tgctccctga agctgagctc tgtgaccgcc gcggacacgg
      361 ccgtgtatta ttgtgcgagt tcgggtatag aagtggttgc ctacagtatt gactactggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007396             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:24598:16931
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007396
VERSION     KCXD01007396.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:24598:16931"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..431
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65878.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       438..445
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          119 c          157 g          119 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccccag aattcccagg tgtttctgtt cggcgatcag
       61 cactaaacac agaacatacc atggagtttg tgctgagctg ggttttcctt gttgctcttt
      121 tgaaaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gtaaagcctg
      181 gggggtccct gagactctcc tgcgcagcct ctggattcag cttcagttat ttctacatga
      241 gctgggtccg tcaggctcca gggaaggggc tggagtggat ctcaagtatt gacagtggtg
      301 ggactaccac aaattatgca gactccgtga ggggcagctt caccatctcc agagagaacg
      361 ccaagaacag actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      421 attgtgcgag agcgcgcggg gtgatcatta catactttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007397             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:20317:2843
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007397
VERSION     KCXD01007397.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:20317:2843"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..494
     V_segment       122..415
                     /gene="IGHV5-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65879.1"
                     /translation="CAKGGWWGDYPPSDWLDVW"
     D_segment       425..436
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT           94 a          146 c          146 g          110 t
ORIGIN      
        1 atgggggagt ctccctcacc gcacagctgg gatctcagtg cttccttttc tgtcctccac
       61 cacgatgggg tcaactgcca tcctcaccct cctactggct gttctccaag gagtctgtgc
      121 cgaggtgcag ctggtgcagt ctggagcaga ggtgaaaagg cccggggagt ctctgaagat
      181 ctcctgtaag acttctggag acacctctac ctactattgg atcagctggg tgcgccagat
      241 gcccgggaaa ggcctggagt ggatgggggc gattgatcct ggtgattctg ataccaaata
      301 tagtccgtcc ttccaaggcc aggtctccat ctcagccgac aagtccatca gcaccgccta
      361 cctgcagtgg agcagcctga aggcctcgga caccgccacg tattactgtg cgaaaggggg
      421 gtggtggggt gattatccac cctcagactg gctcgatgtc tggggcccgg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01007398             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:18612:5961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007398
VERSION     KCXD01007398.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:18612:5961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65880.1"
                     /translation="CAIGPSGSWNAWSFDIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          145 c          135 g           93 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 ccccaggaag aggccttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgag atctgaggac acggccgtat attactgtgc gatcggccct agcggcagtt
      421 ggaacgcctg gtccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007399             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:22783:6710
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007399
VERSION     KCXD01007399.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:22783:6710"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    93..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        93..467
     V_segment       93..400
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65881.1"
                     /translation="CASADSGYPPYFFDIW"
     D_segment       407..416
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>473
                     /gene="IGHG"
BASE COUNT           82 a          140 c          140 g          111 t
ORIGIN      
        1 acatggggag agtcacggac atcctgtgca agaacatgaa gcacctgtgg ttcttcctcc
       61 tcctggtggc agctcccaga tgggtcctgt cccagctgca cctgcaggag tcgggcccag
      121 gactggtgaa gccttcggag accctgtctg tcacctgcgc tgtctctggt ggctctatca
      181 gcagtaccaa ctggagctgg atccgccagg ccccagggaa gggactggag tggattgggt
      241 gtatctttgg tggtggtatc tttggtggtg gaagtaacac cttctacagc ccttccctca
      301 agagtcgagt caccctgtca gtggacgcgt ccaagaccca gctctccctg aagctgacgt
      361 ctgtgaccgc cgcggacacg gccgtgtatt tctgtgcgag cgctgatagt ggttatcctc
      421 cctacttctt tgacatctgg ggccagggag tcctggtcac cgtctcccca gcc
//
LOCUS       KCXD01007400             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7142:13490
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007400
VERSION     KCXD01007400.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7142:13490"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65882.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          114 c          156 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc ggaacctatg
      241 gcatgcactg ggtccgccag gctccaggga tgggcctgga gtgggtgacg gttatatcga
      301 atgatggaag taagaaatac tacgcagact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacgt gaaattggag gacacggccg
      421 tttattactg tgtgagagat gcgtttggta gcgggcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007401             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14284:2504
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007401
VERSION     KCXD01007401.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14284:2504"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65883.1"
                     /translation="CVRYEDEYSDYYFDHW"
     D_segment       403..418
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           94 a          134 c          131 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcacc aatagttatt ggaactggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtct atctatggtg gtactgggag caccggctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaagctga cctctgtgac
      361 cgccgcggac accgccgtat attattgtgt gagatatgag gatgaataca gtgactacta
      421 ctttgaccac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007402             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8478:4825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007402
VERSION     KCXD01007402.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8478:4825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65884.1"
                     /translation="CAIGPSGRWNGWSFDIW"
     D_segment       409..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          106 a          144 c          136 g           89 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccctcaccga agtgtccact cactgggtgc gacaggcccc
      241 cggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc cacagacaca gcctacatgg aactgagcag
      361 cctaagatct gaggacacgg ccgtgtatta ctgtgcgatt ggcccttccg gcaggtggaa
      421 cggctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01007403             483 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20295:18418
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007403
VERSION     KCXD01007403.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20295:18418"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    127..481
                     /note="immunoglobulin heavy chain variable region"
     V_region        127..481
     V_segment       127..406
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>450
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65885.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       420..430
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..481
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        482..>483
                     /gene="IGHG"
BASE COUNT          109 a          146 c          136 g           92 t
ORIGIN      
        1 acatgggggg agcatcacac aacaaccaca tccctcccct acagaagccc cagagcacag
       61 cacctcacca tggactggac ctggaggatc ctcctcttgg tggcagcagc tacaggcgcc
      121 cactctgaag tccagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg
      181 agggtctcct gcaggatttc cggatacacc ttcaccgaat tatccataca ctgggtgcgg
      241 caggcccctg gaaaagggct tgagtggatg ggaagtgttg atcctctgta tggtgaaatg
      301 aagttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc ctacttggaa
      361 ctgagcggcc tgacttctga ggacacggcc gtgtattact gtgcgactgg ccctaccggc
      421 acctggaacg cctggtacct cgatatctgg ggccctggca ccccaatcac catctcctca
      481 gcc
//
LOCUS       KCXD01007404             422 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8102:18870
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007404
VERSION     KCXD01007404.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 422)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 422)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8102:18870"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..420
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..420
     V_segment       63..359
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <351..>389
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65886.1"
                     /translation="CARDEDPSIFEYW"
     D_segment       370..374
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       378..420
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        421..>422
                     /gene="IGHG"
BASE COUNT           82 a          125 c          120 g           95 t
ORIGIN      
        1 acatggggaa gcacctgtgg ttcttcctcc tcctggtggc agctcccaga tgggtcctgt
       61 cccaggtgca gctgcaggag tcgggcccag gactggtgaa gccttcggag accctgtccc
      121 tcacctgcgc tgtctctggt ggcgccatca gcagtggttt ctactggacc tggatccgcc
      181 aacccccagg gaaggggctg gagtggattg ggtgtatcgg tggtaatagt ggtaccacct
      241 actacaagtc ctccctcaag agtcgagcca ccatttcaaa agacacgtcc aacaatcaac
      301 tctccctgaa gttgagttct gtgaccgccg cggacacggc cgtgtattac tgtgcgagag
      361 atgaagaccc ctccattttt gaatactggg gccagggagt cctggtcacc gtctcttcag
      421 cc
//
LOCUS       KCXD01007405             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:26613:14638
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007405
VERSION     KCXD01007405.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:26613:14638"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    98..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        98..467
     V_segment       98..394
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65887.1"
                     /translation="CARRPENSYYFYYFDYW"
     D_segment       410..417
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           98 a          140 c          129 g          102 t
ORIGIN      
        1 acatggggct ctgagagtca tggacctcct gtgcaagaac atgaagcacc tgtggttctt
       61 cctcctcctg gtggcagctc ccagatgggt cctgtcccag gtgaagctgc aggagtcggg
      121 tccaggactg gtgaagcctt cagagaccct gtccctcacc tgcgctgtct ctggaggctc
      181 tatcagcggt gtttatgact ggacctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat gtccatggtg atactgggaa caccgactac aacccgtccc tcaagaatcg
      301 agtcaccatt tcaaaagaca cgtccaagaa ccagttctcc ctgacgctga ggtctgtgac
      361 cgccgcggac acggccgtat attactgtgc gagacgccca gaaaacagtt actacttcta
      421 ctactttgac tactggggcc acggagccct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007406             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:20755:19450
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007406
VERSION     KCXD01007406.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:20755:19450"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65888.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       429..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          116 a          135 c          145 g           98 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aaaaccttca ctgaattatc cattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatct tgcatatgat gaaataatgg
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtattactgt gcggcgggcc
      421 ttgggggata tttactgcat actgaatact tcgagttctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01007407             320 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:5680:8806
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007407
VERSION     KCXD01007407.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 320)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 320)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:5680:8806"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    6..318
                     /note="immunoglobulin heavy chain variable region"
     V_region        6..318
     V_segment       6..257
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <249..>287
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65889.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       270..276
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       277..318
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        319..>320
                     /gene="IGHG"
BASE COUNT           82 a           77 c           88 g           73 t
ORIGIN      
        1 acatgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
       61 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      121 ctgatgcaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      181 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      241 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      301 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007408             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:26901:12687
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007408
VERSION     KCXD01007408.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:26901:12687"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65890.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       424..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          114 a          142 c          148 g           95 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgtaaggtt tccggataca ccgtcagcga attgtccatg cactgggtac gacaggcccc
      241 tgggaaaggg cttgagtgga tgggagttgt tgatcctgtc aatggtgaag aaatacacgc
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tggacagaca cagcctacat
      361 ggacttgacc agtctcagat ctgaggacac ggccatctat tactgtgcga cagggaggat
      421 cggtagcagc ggctggtcca acctcttcac cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007409             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9558:11847
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007409
VERSION     KCXD01007409.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9558:11847"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..512
     V_segment       140..439
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65891.1"
                     /translation="CVRLQSSHYYTFGFHSW"
     D_segment       453..462
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       474..512
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          114 a          127 c          147 g          126 t
ORIGIN      
        1 acatgggggg gagaggagac ccagccttgg gattcccagg cgtctccact tggtgatcag
       61 ctctgaacac aagagactca ccatggaatt tgtactgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagtgtg acgtgcagct ggtagagtct gggggaggct tggtccagcc
      181 tggcgggtcc ctgaggctct cctgtgcagc ctctggattc accttcagtg actatggcat
      241 gagctgggtc cgccaggctt ctgggcaagg actggagtgg gttggctata ttagaagcaa
      301 atctaacaat tacgcgacag aatacgccgc atcggtgaaa ggcaggttcg ccatctccag
      361 agatgattca aagaatacgc tatatctgca aatgagcagt ctgaaaaccg aggacacggc
      421 cgtctattac tgtgtgagac tccagtccag tcactattac actttcggtt tccattcctg
      481 gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007410             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:11716:14319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007410
VERSION     KCXD01007410.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:11716:14319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65892.1"
                     /translation="CARDVYGRGLDFG"
     D_segment       437..442
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          110 c          155 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgaa gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtggc tttggcatgc
      241 actgggtccg ccgggctcca gggaaggggc tggagtgggt ggcagttata tcgtatgatg
      301 aaactaagaa atattacgca gactctgtga aggaccgatt caccgtctcc agagacaatt
      361 ccaagaacat gctatatttt caaatgaaca acctgaaatt ggaagacacg gccgtatatt
      421 actgtgcgag agatgtctat ggcaggggac ttgacttcgg gggcctggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007411             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19897:5911
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007411
VERSION     KCXD01007411.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19897:5911"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65893.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          113 c          155 g          117 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc caatcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaggga ccgattcacc atctccagag
      361 acaattccaa aaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007412             340 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:14237:12783
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007412
VERSION     KCXD01007412.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 340)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 340)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:14237:12783"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..338
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..338
     V_segment       4..277
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <269..>307
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65894.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       283..288
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       292..338
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        339..>340
                     /gene="IGHG"
BASE COUNT           70 a           82 c          105 g           83 t
ORIGIN      
        1 acatggggga ggtttggttc agcctggggg gtccctgaga ctctcctgtg cagcctctgg
       61 attcaccttc agtatctctg gcatgcactg ggtccgccag gctccagggc aggggctgga
      121 ttgggtggca gttgaatcgt ttgatggagg taagaaatac tacgctgact ctgtgaagga
      181 tcgattcccc atctccagag acaattccaa gaacatgcta tatcttcaaa tgagcaacct
      241 gaaattggag gacacggccg tgtattactg tgtgagagat gcctacgggg gcggtttgga
      301 ttcctggggc caaggggtcg tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007413             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:23789:7467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007413
VERSION     KCXD01007413.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:23789:7467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    118..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        118..496
     V_segment       118..409
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <403..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65895.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       424..436
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          113 a          139 c          149 g           97 t
ORIGIN      
        1 acatgggaca caacaaccac atccctcccc tacagaagcc ccagagcaca gcacctcacc
       61 atggactgga cctggaggat cctcctcttg gtggcagcag ctacaggcgc ccactctgag
      121 gtccagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt aaaggtctcc
      181 tgccaggttt ccggatacac cttcagtgaa atgtccatgc actgggtgcg acaggcccct
      241 ggaaaagggc ttgagtggat gggatgtgtt gctcctggaa atggtgaaat aatacacgca
      301 gagaacttcc agggcagagt caccatgacc gaggacacgt ctacagacac agcctacatg
      361 gagctgagta gcctgagatc tgaggacacg gccgtgtatt actgtgcgac agggaggttc
      421 gggagcagcg tctggtccag cctcttctac ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007414             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:24355:15799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007414
VERSION     KCXD01007414.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:24355:15799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    135..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        135..501
     V_segment       135..420
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <417..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65896.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       436..443
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          120 c          142 g          127 t
ORIGIN      
        1 acatggggga ggagcccagc cctgggattc ccaggtgttt tcattcagag atcaggactg
       61 aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt tctatattaa
      121 aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta cagcctgggg
      181 cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat gacatgcact
      241 gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac attggcggtg
      301 acccatacta cccagactct gtgaagggtc gattcaccat ctccagagac aacgccaaga
      361 actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg tattattgtg
      421 tgagggggat ggataactac cacttcagta atacggactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007415             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:17323:8435
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007415
VERSION     KCXD01007415.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:17323:8435"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65897.1"
                     /translation="CGRYSDTDSYYYFDYW"
     D_segment       409..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          137 c          131 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggatctggat ccgccagccc ccagggaagg gactggagtg
      241 gatagggtct atctatggtg ctactgggag caccttttac gaccccgccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccaactttcc ctgaagctgg actctgtggc
      361 cgccgcggac accgccgtgt attactgtgg gagatatagc gatactgata gttattacta
      421 ctttgactac tggggccagg gagtccgggt caccgtctcc tcagcc
//
LOCUS       KCXD01007416             448 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:15595:2440
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007416
VERSION     KCXD01007416.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:15595:2440"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..446
     V_segment       74..364
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <359..>415
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65898.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       389..396
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       403..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>448
                     /gene="IGHG"
BASE COUNT           90 a          114 c          135 g          109 t
ORIGIN      
        1 acatggggga ctcaccatgg agtctgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggtcc agccgggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg gcatgacctg
      181 ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta ttggtggtac
      241 taatagatac tacgcagact ccgtgaaggg ccgattcacc atctccagag acaactcaga
      301 gaaaacgctc tccctgcaaa tgaacagcct gagacctgag gacacggccg tgtatttctg
      361 tgcgtcgaac cttcgtggaa acacctacac ttactggcgg tcctttgact actggggcca
      421 gggagtcctg gtctccgtct cctcagcc
//
LOCUS       KCXD01007417             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:19928:15496
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007417
VERSION     KCXD01007417.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:19928:15496"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65899.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       447..452
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          157 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggcgg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cggaacctat
      241 ggcatgcact gggtccgcca ggctccaggg aagggccttg agtgggtgac ggttatatcg
      301 aatgatggaa gtaagaaata ctacgcggac tctgtgaagg accgattcag catctccaga
      361 gacaattcca agaacatgct atatcttcaa atgaacaacg tgaaattgga ggacacggcc
      421 gtctattact gtgtgagaga tgcgtttggt agcgggcttg actcctgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007418             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14387:14188
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007418
VERSION     KCXD01007418.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14387:14188"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65900.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          121 a          141 c          134 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctgttgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacatctt aaccgaatta tccatacact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg gagtgttgat cctcaatatg gtgagatgat
      301 agacgcagag aaattccagg gcagagtctc catgaccgag gacacgtcta cagacacagc
      361 ctacatagag ctgagcagtc tgagatctga ggacacggcc gtgtattact gtgcgacatc
      421 atccagcggc acctggctat actggtactt cgatatctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01007419             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18175:16222
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007419
VERSION     KCXD01007419.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18175:16222"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65901.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          115 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 ctgatgaaag taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007420             368 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18613:11831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007420
VERSION     KCXD01007420.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 368)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 368)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18613:11831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..366
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..366
     V_segment       5..296
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <288..>335
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65902.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       306..312
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       322..366
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        367..>368
                     /gene="IGHG"
BASE COUNT           75 a           96 c          115 g           82 t
ORIGIN      
        1 acatggggca gctggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
       61 tctcctgcgc agcctctgga ttcagcttca gttactactt catgagttgg gtccgccagg
      121 ctccagggaa ggggctggag tggatctcag gtattaccag tggtggggat aacacatact
      181 ctgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag accacactgt
      241 atcttcacat ggacagcctg agagctgagg acacggctgt ctattactgt gcaagagatc
      301 gacgtgtaca gtcgttatcc tggttcgatg tctggggccc gggagtcctg gtcaccgtct
      361 cctcagcc
//
LOCUS       KCXD01007421             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:18443:14320
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007421
VERSION     KCXD01007421.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:18443:14320"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65903.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       440..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          108 c          154 g          119 t
ORIGIN      
        1 atggggctgg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagctt cggggttcat cttcagtagt tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagtaaca tcgtctgatg
      301 aaagtaagaa attctacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 cccagaacat actatatctt caaatgaaca acctgaaatt gaaggacacg gccgtctact
      421 attgtgggag agatgataat ggggtgatta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007422             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:21975:10346
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007422
VERSION     KCXD01007422.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:21975:10346"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..517
     V_segment       145..444
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <436..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65904.1"
                     /translation="CVRLQSSHYYTFGFHSW"
     D_segment       458..467
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       479..517
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          114 a          129 c          148 g          128 t
ORIGIN      
        1 acatgggggc tctgggagag gagacccagc cttgggattc ccaggcgtct ccacttggtg
       61 atcagctctg aacacaagag actcaccatg gaatttgtac tgagctgggt tttccttgtt
      121 gctattttaa aaggtgtcca gtgtgacgtg cagctggtag agtctggggg aggcttggtc
      181 cagcctggcg ggtccctgag gctctcctgt gcagcctctg gattcacctt cagtgactat
      241 ggcatgagct gggtccgcca ggcttctggg caaggactgg agtgggttgg ctatattaga
      301 agcaaatcta acaattacgc gacagaatac gccgcatcgg tgaaaggcag gttcgccatc
      361 tccagagatg attcaaagaa tacgctatat ctgcaaatga gcagtctgaa aaccgaggac
      421 acggccgtct attactgtgt gagactccag tccagtcact attacacttt cggtttccat
      481 tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007423             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:15812:15991
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007423
VERSION     KCXD01007423.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:15812:15991"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65905.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       403..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           97 a          135 c          136 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgg tgtctctggt
      181 ggctccttca gcggttacta ttggagctgg atccgccagt ccccagggaa ggggctggag
      241 tggattgggt atatcagtgc tagtagtggg agtaccgact acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaat taccatttct ccctgaagct gacctctgtg
      361 accgccgcgg acacggccgt atattactgt gcgagagaga agtactatag tggtagttat
      421 aaacacaact ggttcgatgt ctggggcccg ggagtccagg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007424             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22161:12833
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007424
VERSION     KCXD01007424.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22161:12833"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..478
     V_segment       112..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65906.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       411..417
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          116 a          137 c          131 g           96 t
ORIGIN      
        1 acatgggcaa ccacatccct cccctacaga agccccagag cacagcacct caccatggac
       61 tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc tgaggtccac
      121 ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt ctcctgcaag
      181 gtttccggat acatcttaac cgaattatcc atccactggg tgcgacaggc ccctggaaaa
      241 gggcttgagt ggatgggaag tgttgatcct caatatggtg aaatgataga cgcagagaaa
      301 ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta catggagctg
      361 agtagtctga gatctgagga cacggccgtg tattactgtg cgacatcatc cagcggcact
      421 tggctatact ggtacttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01007425             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:12860:7464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007425
VERSION     KCXD01007425.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:12860:7464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..374
     V_segment       20..313
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65907.1"
                     /translation="CARDVYGRGLDYW"
     D_segment       319..324
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       333..374
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           85 a           84 c          118 g           89 t
ORIGIN      
        1 acatgggggt gtccagtgtg aagtgcaact ggtggagtct ggaggaggct tggttcagcc
       61 gggggggtcc ctgagactct cctgtgcagc ctctggattc agcttcagtg gctttggcat
      121 gcactgggtc cgccaggctc cagggaaggg gctggagtgg gtggcagtta tatcgtatga
      181 tgaaactaag aaatattacg cagactctgt gaaggaccga ttcaccgtct ccagagacaa
      241 ttccaagaac atgctatatt ttcaaatgaa caacctgaaa ttggaagaca cggccgtgta
      301 ttactgtgcg agagatgtct atggcagggg acttgactac tggggcctgg gagtcctggt
      361 caccgtctcc tcagcc
//
LOCUS       KCXD01007426             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:27677:15040
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007426
VERSION     KCXD01007426.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:27677:15040"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65908.1"
                     /translation="CVRYEDEAINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          137 c          129 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgttg tctctggtga
      181 ctccatcacc agtagctact ggaactggat ccgccagccc cccgggaagg gactggaatg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaagagtcg
      301 agtcagcatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attactgtgt gagatatgag gatgaagcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007427             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10297:10126
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007427
VERSION     KCXD01007427.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10297:10126"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..505
     V_segment       142..435
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65909.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       445..451
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..505
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          110 a          120 c          157 g          120 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ccagaattcc caggtgtttc tgttcggcga
       61 tcagcacaaa acacagaaca taccatggag tttgtgctga gctgggtttt ccttgttgct
      121 cttttgaaag gtgtccagtg tgaggtgaag ctggtggagt ctgggggcgg cttggcaaag
      181 cctggggggt ccctgagact ctcctgcgca gcctctggat tcagcttcaa ttattactac
      241 atgagctggg tccgccaggc tccagggaag gggctggagt ggatctcagg tattaatagt
      301 ggtggggaaa gcacatactc tgcagactcc gtgaagggca gattcaccat ctccagagag
      361 aacgccaaga acacgctata tcttgaaatg gacagcctga gaactgagga cacggctgtc
      421 tattattgtg tgagagatcg acgtgtacag tcgttatcct ggttcgatgt ctggggcccg
      481 ggagccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007428             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15992:16273
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007428
VERSION     KCXD01007428.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15992:16273"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..469
     V_segment       91..390
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <382..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65910.1"
                     /translation="CAREAYSWNNLYFYGLDSW"
     D_segment       397..411
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          103 a          111 c          145 g          112 t
ORIGIN      
        1 acatgggtca gcactgaaca caaaccacca gccatggagt ttgggctgag ctgggttttc
       61 cttgttgcta tttggaaagg tgtccaatgt gaggtgcagc tggtggagtc cgggggaggc
      121 ttggtccagc ctggcgggtc cctgagcctc tcctgtgcag cctctggatt caccttcggt
      181 gattctggta tggactgggt ccgccaggct ccaggaaagg ggctggagtg ggtaggtttc
      241 attagaagca aaacttatgg tgggacagca gaatactccg cgtctgtgaa gggcagattc
      301 accatctcca gagatgattc aaagaacacg gcgtatctgc agatgaccag cctgaaaacc
      361 gaggacacgg ccgtatatta ctgtgctaga gaggcgtata gttggaacaa cctatatttc
      421 tacggtttgg attcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01007429             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7308:6778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007429
VERSION     KCXD01007429.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7308:6778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..389
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65911.1"
                     /translation="CGNGARRTLGDYW"
     D_segment       390..394
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           79 a          137 c          139 g          102 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcacg aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc cagatgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggtat atcggtggta ctagtgggag caccttctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgatgctga cctctgtgac
      361 cgccgcggac acggccgtct atttttgtgg taacggggcc cgacgtactt tgggggacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007430             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:16879:11455
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007430
VERSION     KCXD01007430.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:16879:11455"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65912.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          109 a          118 c          151 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcgccctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtcgc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttttg tcgtctgatg
      301 gaggttacaa ataccacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007431             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:15572:20837
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007431
VERSION     KCXD01007431.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:15572:20837"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65913.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       443..448
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          111 a          113 c          154 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcgga acctatggca
      241 ttcactgggt ccgccaggct ccagggaagg gcctggagtg ggtgacggtt atatcgaatg
      301 atggaagtaa gaaatactac gcagactctg tgaaggaccg attcagcatc tccagagaca
      361 attccaagaa catgctatat cttcaaatga acaacgtgaa attggaggac acggccgttt
      421 attactgtgt gagagatgcg tttggtagcg ggcttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007432             346 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22406:9108
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007432
VERSION     KCXD01007432.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 346)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 346)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22406:9108"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..344
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..344
     V_segment       8..274
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <266..>313
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65914.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       278..285
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       300..344
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        345..>346
                     /gene="IGHG"
BASE COUNT           71 a          103 c           92 g           80 t
ORIGIN      
        1 acatggggga ctggtcaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
       61 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      121 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaggagtcg
      181 agtctccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctgc gttctgtgac
      241 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      301 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007433             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:18627:12607
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007433
VERSION     KCXD01007433.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:18627:12607"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..393
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65915.1"
                     /translation="CASGRRQLDLDYW"
     D_segment       405..411
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           85 a          142 c          129 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctacacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgg
      181 ctctatcagc acttactact ggaactggat ccgccaggcc ccagggaggg gacttgactg
      241 gattggacat atctatggta gtggtgatgg caccaactac aacccctccc tccagagtcg
      301 agtcaccctg tcagttgaca cgtccaagaa ccatttctcc ctgaccctga ggtctgtgac
      361 cgccgcggac acggccgtct attactgtgc gagcggtcgg cggcaactgg accttgacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007434             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:12572:5626
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007434
VERSION     KCXD01007434.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:12572:5626"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..505
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65916.1"
                     /translation="CARVDCSGGVCYFDYW"
     D_segment       444..464
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>509
                     /gene="IGHG"
BASE COUNT          115 a          117 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtg ttccttgttg
      121 ctattttaag aggtgcccag tgtgaggtgc aactggtggg gtctggcgga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttt agtagccatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca attatatcgt
      301 atgatggaaa tgagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa taaacaacct gaaattggag gacacggcca
      421 tgtattactg tgcgagagtg gactgtagtg gtggtgtctg ctactttgac tattggggcc
      481 agggagtcct cgtcaccgtc tcctcggcc
//
LOCUS       KCXD01007435             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:10914:9906
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007435
VERSION     KCXD01007435.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:10914:9906"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65917.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       409..421
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           93 a          138 c          127 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc aatagctact ggatctggat ccgccagccc ccagggaagg ggctggagtg
      241 gatagggtct atctatggtg gtactgggag caccttttac gacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaacaa ccaattttcc ctgaagctgg actctgtgac
      361 cgccgcggac accgccgtct attactgtgc gagatatagc gatactgata gttattacta
      421 ctttgactac tggggccagg gagtccgggt caccgtctcc tcagcc
//
LOCUS       KCXD01007436             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:18605:6957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007436
VERSION     KCXD01007436.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:18605:6957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65918.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           97 a          138 c          125 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccaatagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattggat atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt gtattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007437             345 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:10484:16685
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007437
VERSION     KCXD01007437.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 345)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 345)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:10484:16685"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..343
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..343
     V_segment       7..256
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>312
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65919.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       279..285
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       294..343
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        344..>345
                     /gene="IGHG"
BASE COUNT           80 a           89 c          103 g           73 t
ORIGIN      
        1 acatgggggg cctcagttag ggtctcctgc aaggtttccg gaaacacctt caccgaatta
       61 tccatgcact gggtgcgaca ggcccctgga aaagggcttg agtggatggg atgtgtcgat
      121 cctgcacaag gtgaaataat acacgcagag aaattccagg gcagagtcac catgaccgag
      181 gacacgtcta cagacacagc cttcatggaa ttgagcagcc tgagatctga ggacacggcc
      241 gtgtatttct gtgcgaaagg ggggttcgga accagcgtct ggtccaacct cttctacggt
      301 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01007438             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:14396:10109
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007438
VERSION     KCXD01007438.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:14396:10109"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65920.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          114 a          121 c          148 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagcctctg gattcatctt cagtaactat
      241 gccatgcact gggtccgcca ggctccaggg aaggggctag agtgggtggc agttatttcg
      301 catgatggaa ctaagaaata ctacacagac tctgcgaagg accgattcac catctccaga
      361 gacaattcca agaacataca atatcttcac atgaacagcc tgaaattgga ggacacggcc
      421 atatactact gtgcggcctc ctacttgggg tacggttttg agtactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007439             401 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:5280:10051
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007439
VERSION     KCXD01007439.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 401)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 401)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:5280:10051"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    45..399
                     /note="immunoglobulin heavy chain variable region"
     V_region        45..399
     V_segment       45..338
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <330..>368
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65921.1"
                     /translation="CVRDDLGSGLGSW"
     D_segment       349..357
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       365..399
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        400..>401
                     /gene="IGHG"
BASE COUNT           88 a           88 c          123 g          102 t
ORIGIN      
        1 acatgggggt tttccttgtt gcgattttaa gaggtgtcca gtgtgaggtg cagctggtgg
       61 agtctggagg aggcttggtt cagccggagg ggtccctgag actctcctgt gcagcctctg
      121 gattcacctt cagtttctat ggcatacact gggtccgcca ggctccaggg aaggggctgg
      181 agtgggtggc agttatttcg aatgatgaaa ctaagaaata ctacgcagac tctgtgaagg
      241 accgattcac catttccaga gacaattcca agaggatgct atttcttcaa atgaacaacc
      301 tgaaattgga ggacacggcc gtctattact gtgtgagaga tgatttaggc agcggcttag
      361 ggtcctgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007440             418 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9034:20393
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007440
VERSION     KCXD01007440.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 418)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 418)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9034:20393"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    50..416
                     /note="immunoglobulin heavy chain variable region"
     V_region        50..416
     V_segment       50..343
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <335..>385
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65922.1"
                     /translation="CARDRDTRSGYYGLDSW"
     D_segment       357..365
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       368..416
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        417..>418
                     /gene="IGHG"
BASE COUNT           92 a           96 c          128 g          102 t
ORIGIN      
        1 acatgggagc tgggttttcc ttgttgctat tttaagaggt gtccagtgtg aggtgcagct
       61 ggtggagtct ggaggaggct tggttcagcc tggggggtcc ctgagactct cctgtgcagc
      121 ctctggactc accttcagta cctctggcat gcactgggtc cgccaggctc cagggaaggg
      181 gctggagtgg gtggcagtta tatcgtatga tggaagtaag aaatactacg cagactctgt
      241 gaaggaccga ttcaccatct ccagagacaa ttccaagaac atgctatatc ttcaaatgaa
      301 caacctgaaa ttggaggaca cggccgtata ttactgtgcg agagataggg atacacgcag
      361 cggctattac ggtttggatt cctggggccg aggggtcgtc gtcaccgtct cctcagcc
//
LOCUS       KCXD01007441             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:10974:8825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007441
VERSION     KCXD01007441.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:10974:8825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..493
     V_segment       114..405
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65923.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       415..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>497
                     /gene="IGHG"
BASE COUNT          114 a          136 c          144 g          103 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag ctctcctgca
      181 aggcttctgg attcacgttc agcaccgatg ccatcagttg ggtgcgacag gcccctggac
      241 aagggcttga ttggatggga ggggtcatcc ctcttatggg tacaacaaac tacgcacaga
      301 agttccaggg cagagtcacg tttaccgcgg acacgtcact aagcacagcc tacatggaac
      361 tgagcagcct gagatctgag gacacggccg tgtattattg tgcgaaatcc gtgaattacg
      421 aggaagataa cggttactat ataccgacgc agtttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctctgcc
//
LOCUS       KCXD01007442             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:21718:9730
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007442
VERSION     KCXD01007442.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:21718:9730"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65924.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..451
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          114 a          112 c          151 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agttggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agaaactttg
      241 gcatgcactg ggtccgccag gccccaggga aggggctgga ttgggtggca gttatgtcgt
      301 ttgatgaaaa tgtgaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatggta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tgtattactg tgcgagaggg gaatacagta attctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcgtcagcc
//
LOCUS       KCXD01007443             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:18114:11634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007443
VERSION     KCXD01007443.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:18114:11634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65925.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       429..437
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..490
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          125 c          147 g          105 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccccaca gaagccccag agcaaagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcggccac
      121 tctgaggtcc agttggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacagtgtc accgaattat cgattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgtaaaagg tgaagaaatt
      301 cacggagagg agttccagga cagagtcacc atgaccgatg acccgtctac agacacagcc
      361 tacatggagt tgagcaacct gagatctgag gacacggccg tgtattattg tgcgagtggg
      421 tttagtatct ggttatttta cgacgttttg gattcctggg gccaaggggt cgtcgtcacc
      481 gtctcctcag cc
//
LOCUS       KCXD01007444             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:16615:4813
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007444
VERSION     KCXD01007444.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:16615:4813"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65926.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          140 c          125 g          108 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcagtagcta ctggaactgg atccgccagc ccccagggag gggactggag
      241 tggattggct atatctctgg tgcttatggg agcaccaact acaacccctc cctcaagagt
      301 cgagccacca tttccacaga cacgtccaag aaccactttt ccctgaggct gaattctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007445             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:11346:16593
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007445
VERSION     KCXD01007445.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:11346:16593"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..401
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65927.1"
                     /translation="CAVGPSGTWNHWPFDIW"
     D_segment       410..417
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          150 c          132 g           91 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcccggggcc tcagtgaagg
      181 tctcctgcaa ggtctccgga aacaccttca ccgaattgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc cgcatatggt gaaatgacgt
      301 tccagggcag agtcatcatg accgaggaca cgtctacaga cacagcctac atggagctga
      361 ccagcctgac atctgacgac acggccgtct attactgtgc ggttggccct agcggcactt
      421 ggaaccactg gcccttcgat atctggggcc ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007446             443 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:18516:7786
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007446
VERSION     KCXD01007446.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 443)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 443)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:18516:7786"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    84..441
                     /note="immunoglobulin heavy chain variable region"
     V_region        84..441
     V_segment       84..379
                     /gene="IGHV2-173"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>410
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65928.1"
                     /translation="CARGRTTSPFDYW"
     D_segment       386..393
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..441
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        442..>443
                     /gene="IGHG"
BASE COUNT           97 a          143 c          108 g           95 t
ORIGIN      
        1 acatgggggg actcctgtgc cccaccatgg acacgctttg ctccacgctc ctgctgctga
       61 ccgtcccgtc ctgggtcttg tcccaggtga ccttgaagga gtctggtcct gcgctggtga
      121 aacccactca gcccctcacg ctgacatgca ccttctctgg gttctcactc agcactactg
      181 gaacgggtgt gacctggatc cgtcagcccc caggcaaggc cctggaatgg cttacaacca
      241 tttattggga tgatgataag tactacagca catctctgaa gaccagactc accatctcca
      301 aggacacctc caaaaaccag gtggttctaa caatgaccaa catggaccct gtggacacag
      361 ccacatatta ctgtgcacga gggaggacta ccagcccttt tgactactgg ggccagggag
      421 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007447             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:13824:3444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007447
VERSION     KCXD01007447.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:13824:3444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..496
     V_segment       114..405
                     /gene="IGHV1-58"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65929.1"
                     /translation="CVKGSPNYDSAYYTTPSEYFDFW"
     D_segment       418..440
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..496
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          116 a          144 c          131 g          109 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tcccaggtcc
      121 agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaaa gtctcctgca
      181 aggcttctgg atacatcttc aacatctatg ccatcaattg ggtgcgactg gcccctggac
      241 aaggacttga gtgggtggga gggatcatcc ctcttgttgg aatgacaaac tacgcacaga
      301 agttccagga cagactcaca attaccgcgg acacgtccac aggcacagcc tacatggaac
      361 tgagcagcct aagatctgag gacacggcca tctattactg tgtgaaaggt tctcctaact
      421 atgatagtgc ttattacacc accccctctg aatatttcga cttttggggc cagggcgccc
      481 tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01007448             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:6233:7715
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007448
VERSION     KCXD01007448.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:6233:7715"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..492
     V_segment       125..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65930.1"
                     /translation="CAAGLGGYLLLTEYLEFW"
     D_segment       431..441
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       444..492
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>496
                     /gene="IGHG"
BASE COUNT          115 a          143 c          144 g           94 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gacacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggctggg aggtgttgat cttgtatatg atgaaataac
      301 acacgcagag aagttccaag gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggaa ctgagcagcc tgagatctga ggacacggcc gtgtattact gtgcggcggg
      421 ccttggggga tatttactgc tcactgaata cctcgagttc tggggccagg gcgccctggt
      481 caccgtctcc tccgcc
//
LOCUS       KCXD01007449             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11010:20988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007449
VERSION     KCXD01007449.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11010:20988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65931.1"
                     /translation="CATGRIGSSGWSSLFTGLDSW"
     D_segment       435..444
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          112 a          144 c          152 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 gctctgaggt ccacctggtg cagtctgggg ctgaggtgaa gcagcctggg gcctcagtga
      181 aggtctcctg taaggtttcc ggatacaccg tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg gaaagggctt gagtggatgg gagttgttga tcctgtcaat ggtgaagaaa
      301 tatacgcaga gaggttccag ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga cttgaccagt ctcagatctg aggacacggc catctattac tgtgcgacag
      421 ggaggatcgg tagtagcggc tggtccagcc tcttcaccgg tttggattcc tggggccgag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007450             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:8081:19737
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007450
VERSION     KCXD01007450.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:8081:19737"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65932.1"
                     /translation="CARWSAANFDYW"
     D_segment       404..410
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           89 a          137 c          134 g           99 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgggca agaacatgaa gcatctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca actgcaggag
      121 tcgggcccag gactggtgaa gccctcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca acagtggtta tggctggagc tgggtccgcc agcccccagg gaaggggctg
      241 gagtggattg ggtgtctcta tgatagtagt gggaacacgt actacaaccc ctccctcaag
      301 agtcgcgtca ccatttcaaa agacacgtcc aagaaccagt tctccctgaa cctgaggtct
      361 atgaccgccg cggacacggc cgtctattac tgtgcgagat ggtcggcagc caactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007451             489 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:25742:15702
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007451
VERSION     KCXD01007451.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 489)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 489)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:25742:15702"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..487
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..487
     V_segment       124..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>456
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65933.1"
                     /translation="CVAADSGYPFYYFDIW"
     D_segment       420..428
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..487
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        488..>489
                     /gene="IGHG"
BASE COUNT          112 a          143 c          131 g          103 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggcc gaagtgaaga agcctggggc ctcagtgagg
      181 gtctcctgca aggtttccgg acacaccttc agcgaattat ccattcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggttgga ggttttgctc ctatatatgg tgaaatccta
      301 cacacagaca agttccaggg cagagtcacc ttgaccgagg acacgtctac agacaccgcc
      361 tatatggagt tgagcagcct gagatctgag gacacggccg tatattactg tgtggcggct
      421 gatagtggtt acccttttta ctacttcgat atctggggcc ctggcacccc aatcatcatc
      481 tcctcagcc
//
LOCUS       KCXD01007452             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:22393:16463
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007452
VERSION     KCXD01007452.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:22393:16463"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..500
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65934.1"
                     /translation="CARRPWNADYFDYW"
     D_segment       443..449
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..500
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          114 a          113 c          151 g          124 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtaca attggtggag tctggaggag gtttggttca
      181 gcctgggggg tccctgagac tctcctgtga agcttctgga ttcaccttca gtaactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgta
      301 tgatgtaagt aggaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattctaag aacatgctat atcttcaaat gagcaacctg aaattggagg acacggccgt
      421 gtatttctgt gcgagacgcc cttggaacgc tgactacttt gactactggg gccagggagt
      481 cctggtcacc gtctcgtcag cc
//
LOCUS       KCXD01007453             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11706:13029
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007453
VERSION     KCXD01007453.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11706:13029"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..476
     V_segment       122..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <395..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65935.1"
                     /translation="CAVGPTGRWNGWSFDIW"
     D_segment       412..424
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..476
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT          107 a          144 c          137 g           90 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtcctt ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccctcac cgaagtgtcc actcactggg tgcgacaggc
      241 ccccggaaaa gggcttgagt gggtgggaag tgttgatcct gcatatggtg aaatgaagtt
      301 ccagggcaga gtcaccatga ccgaggacac gtccacagac acagcctaca tggaactgag
      361 tagcctaaga tctgaggaca cggccgtgta ttactgtgcg gttggcccta ccggcaggtg
      421 gaacggctgg tccttcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01007454             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:4382:10405
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007454
VERSION     KCXD01007454.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:4382:10405"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..493
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65936.1"
                     /translation="CARRGGHGTTTTLYFFDYW"
     D_segment       442..448
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          110 a          144 c          141 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgatgaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccctcagc atctctgcca tcagttgggt acgacaggcc
      241 cctggacaag ggcttgagtg gatgggagag atcttccctc ttgttggtgt gacaaaatac
      301 gaacagaact tccagggcag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctgc gcggcctgag atctgaggac acggccgtat attactgtgc gagaagaggt
      421 ggccacggta ccaccaccac gttgtacttc tttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007455             523 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:19326:13464
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007455
VERSION     KCXD01007455.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 523)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 523)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:19326:13464"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..521
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..521
     V_segment       146..438
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <437..>490
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65937.1"
                     /translation="CSTWRYYYSVGYPTFDYW"
     D_segment       451..464
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       478..521
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        522..>523
                     /gene="IGHG"
BASE COUNT          118 a          121 c          153 g          131 t
ORIGIN      
        1 acatggggag ctctgggaga ggagacccag ccttgggatt tccagctgtc tccacttggt
       61 gatcagcact gaacacagga gactcgccat ggagtttgta ctgagctggg ttttccttgt
      121 tgctatatta aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gaggcttggt
      181 ccagcctggc gggtccctga gactctcctg tgcagcctct ggattcatct tcagtgactt
      241 tgccatgagt tgggtccgcc aggcttctgg gaaaggactg gagtgggttg gctatgttag
      301 aaccaaatat aacaattacg cgacagaata cgccgcatcg gtgaaaggca gattcaccat
      361 ctccagagat gattcaaaga acacgatata tctgcaaatg agcagcctga aaaccgagga
      421 cacggccgtg tatttctgca gcacatggag gtattattat agtgttggtt atcccacctt
      481 tgactactgg ggccagggag tcctggtcgc cgtctcctca gcc
//
LOCUS       KCXD01007456             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:17124:6808
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007456
VERSION     KCXD01007456.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:17124:6808"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65938.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       432..443
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          135 c          152 g          107 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgcgag gtgcacctgg tggagtctgg gggcggcctg gcaaagcctg
      181 ggggagccct gagcctctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ctcagctatt agtagtggtg
      301 gcaccacata ctacgcagac tccgtgaagg gccgattcac cgtctccaga gacaactcaa
      361 agaacacgct ctccctgcaa atgaacagcc tgagagctga ggacacggcc gtgttttact
      421 gtgcgaaagc cgatacagct acaccatact acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007457             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:23705:15444
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007457
VERSION     KCXD01007457.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:23705:15444"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..488
     V_segment       101..394
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65939.1"
                     /translation="CARHRTSDYYSGSYPNPFRSFDFW"
     D_segment       408..426
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT           89 a          152 c          142 g          107 t
ORIGIN      
        1 acatgggggt tctctgagag tcacagacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccaggtg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggagaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactact ggagctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtac atcaatggtg ccagtgggag taccacctac aacccgtccc tccagagtcg
      301 agtcgccatt tccattgaca cgtccaagaa ccggttctcc ctgaggctga actctgtgac
      361 cgccgcggac gcggccgtgt attactgtgc gcgacatcgg acgtcggatt actatagtgg
      421 cagttaccca aaccccttcc gctcctttga cttctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007458             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9701:5831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007458
VERSION     KCXD01007458.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9701:5831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    116..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        116..491
     V_segment       116..409
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65940.1"
                     /translation="CSRGSNYEDAYDYFSAFDSW"
     D_segment       417..440
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          109 a          136 c          140 g          108 t
ORIGIN      
        1 acatggggac aaccacgtcc ctcctctaaa gaagcccctg ggaacacagc tcatcaccat
       61 ggacttgacc tggaggctcc tctttgtggt ggcagcagct acaggtgccc agtcccaggt
      121 ccagctggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga agctctcctg
      181 caaggcttct ggatacacct tcagcatcta tgccatcaat tgggtgcgac aggcccctgg
      241 acaagggctt gagtggatgg gagggatcat ccctcttgtt ggtataacaa actacgtaca
      301 gaagttccag ggcagagtca cgattaccgc ggacacgtcc acaagcatag cctacatgga
      361 gctgagcggc ctaagatctg aggacccggc cgtgtattac tgttcgagag ggtcaaatta
      421 cgaggatgct tacgattact tttctgcctt tgactcctgg ggccagggag tcctggtcac
      481 cgtctcctca gtc
//
LOCUS       KCXD01007459             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:24590:8819
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007459
VERSION     KCXD01007459.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:24590:8819"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65941.1"
                     /translation="CATSSSGTWLYWYFDVW"
     D_segment       430..436
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          116 a          141 c          139 g           97 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctccccgac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaggta caggcgccca
      121 ctctgaggtc cagctggtgc agtcgggggc tgaggtgaag aagcctgggg cctcagtgca
      181 ggtctcctgt aaggtttccg gatactcctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aagtgttgat cctgtgtatg gtgaaataat
      301 aaattcagag aagttccagg gcagagtcac cttgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggatacggcc gtgtattact gcgcgacatc
      421 atccagcggc acctggctat actggtactt cgatgtctgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01007460             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:22670:14449
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007460
VERSION     KCXD01007460.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:22670:14449"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65942.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          124 c          154 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttaat ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acgctggtgg
      301 ggataccaca tactatgcag actccgtgaa gggcagatcc accatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007461             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:19442:12885
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007461
VERSION     KCXD01007461.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:19442:12885"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..463
     V_segment       109..402
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65943.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       408..413
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..463
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT          101 a          101 c          145 g          118 t
ORIGIN      
        1 acatgggcag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgttgctatt ttaagaggtg tccagtgtga ggtgcagctg
      121 gtggagtctg gaggcggctt ggttcagcct ggggggtccc tgagactctc ctgtgtagcc
      181 tctggattta ctttcagtag tagtggcatg cactgggtcc gccaggctcc agggaagggg
      241 ctggagtggc tggctgttga atcgcatgat ggaaataaga aatactatgc agactccgtg
      301 aaggaccgat tcaccatctc cagagacaat tccaagaaca tggtatatct tcaaatgaac
      361 agcctgaaat tggtggatac ggccatgtat tactgtgtga gagatgccta cgggggcggt
      421 ttggattcct ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01007462             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:23492:15604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007462
VERSION     KCXD01007462.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:23492:15604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    109..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        109..466
     V_segment       109..401
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65944.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       407..412
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..466
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT          109 a          103 c          139 g          117 t
ORIGIN      
        1 atggggacag tgttccattc ggtgatcagc acagaacaca gaggactcac catgaagttt
       61 gggctgagct gggttttcct tgttgctatt ttaagaggtg tccagtgtga ggtgcagctg
      121 gtggagtctg gaggaggctt ggttcagcct ggggggtccc tgagactctc ctgtgcagcc
      181 tctggattca cgttcagtaa ctatggaatg cactgggtcc gccaggctcc agggaagggg
      241 ctggagtggg tggcagttat atcgtacgat gaaaataaga aatactacgc agactctctg
      301 aaggaccgat tcaccatctc cagagacaat tccaagaaca tgctttatct tcaaatgaac
      361 aacctgaaat tggaggacac ggccgtttat tactgtgcga ggaggccctg gagtgcagat
      421 gcttttgatt tctggggcca aggactcagg gtcaccgtct cttcagcc
//
LOCUS       KCXD01007463             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10705:17944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007463
VERSION     KCXD01007463.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10705:17944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65945.1"
                     /translation="CARYGDDSVHYNFDYW"
     D_segment       405..412
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          140 c          130 g          105 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcggccccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtggctt ctggaactgg atccgccagc ccccagggaa ggggctggag
      241 tggcttgggt acatctatgg tagcactggg agcaccggct acaacccctc catcaagagt
      301 cgagtcacca tttcaacaga cacgtcaaag aaccacttct ccctgaagct gagctctgtg
      361 accgccgcgg acaccgccgt gtatttctgt gcgagatatg gagatgatag tgttcattac
      421 aactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007464             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18645:6062
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007464
VERSION     KCXD01007464.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18645:6062"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..503
     V_segment       143..436
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65946.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       443..450
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          106 a          122 c          156 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gctggtggag tctgggggcg gcttggtaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gttatttcta
      241 catgagctgg gtccgtcagg ctccagggaa ggggctggag tggatctcaa gtattgacag
      301 tggtgggact accacaaatt atgcagactc cgtgaggggc agcttcacca tctccagaga
      361 gaacgccaag aacacactgt atcttcaaat ggacagcctg agagctgagg acacggctgt
      421 ctattattgt gcgagagcgc gcggggtgat cattacatac tttgactcct ggggccaggg
      481 agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007465             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8840:8309
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007465
VERSION     KCXD01007465.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8840:8309"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65947.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           91 a          139 c          128 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtcaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atctctggtg cttatgggag caccagctac aacccctccc tcaggagtcg
      301 agtctccatt tcaacagaca cgtccaagaa ccacttttcc ctgaggctgc gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007466             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:19223:10217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007466
VERSION     KCXD01007466.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:19223:10217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    91..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        91..472
     V_segment       91..383
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <376..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65948.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       393..416
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          103 a          128 c          143 g          100 t
ORIGIN      
        1 acatgggggc ccctgggaac acagctcatc accatggact tgacctggag gctcctcttt
       61 gtggtggcag cagctacagg tgcccagtcc caggtccagt tggtgcagtc cggggctgag
      121 gtgaagaggc ctggggcctc agtgaagctc tcctgcaagg ctcctggata catcttcagt
      181 atatctgcca tcagttgggt gcgacaggcc cctggacaag ggcttgagtg gatgggaggg
      241 atcatccctc ttgttggtgt aacaaccaac gcacagaagt tccaggacag agtcacgatt
      301 accgcggaca cgtccacaag cacagcctac atggagctga gcagcctgag atctgaggac
      361 acggccgtgt atttctgtgc gagtggcggc ttcgaggatg ataacggtca ctattatacg
      421 acactaacat ttcacgattg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007467             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15674:15165
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007467
VERSION     KCXD01007467.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15674:15165"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65949.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       442..454
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          113 c          157 g          118 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagcctgggg ggtccctgag actctcctgt gcagtctctg gattcacctt cagtagcttt
      241 ggcatgcact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agtgacatcg
      301 tatgatggaa gttggaagta ctacggagac tctgtgaagg accgattcac catctccaga
      361 gacaattcca agaacatgct atatcttcag atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgcgagagg ggaatacagt aactctattg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007468             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:16462:5054
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007468
VERSION     KCXD01007468.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:16462:5054"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65950.1"
                     /translation="CATHGGYSDIWNSLYNGLDSW"
     D_segment       438..445
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          123 a          143 c          141 g           97 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagccac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagttaaga agcctggggc ctcagtgatg
      181 gtctcctgcc aggtttccgg atacaccgtc accgaaatat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgctc ctgaaaaaaa tgagttaata
      301 cacgcagaca agttccagga cagagtcagc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtggcct gacatttgag gacacggccg tgtattactg tgcgacccac
      421 ggaggttata gcgacatctg gaactcccta tataacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007469             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25845:6619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007469
VERSION     KCXD01007469.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25845:6619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..488
     V_segment       119..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65951.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       413..421
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..488
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          111 a          138 c          144 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagttg gtgcagtctg gggctgaagt gaggaagcct ggggtctcag taaaggtctc
      181 ctgcaaggtt tccggaaaca ccatcaccga attatccgtg cactgggtgc gacaggcccc
      241 tggaaaaggc cttgagtgga tggggggtgt tgatcccgtc tatggtgaaa taagacacgc
      301 agagaacttc cagggcagag tcaccatgac cgaggacacg tcgacagaca cagcctacat
      361 ggagctgagc agcctgagat ctgaggacac ggccgtctat tactgtgcgc gaggatattg
      421 tcatggtagt tactgttcct cgggtcttgt ctcctggggc cagggagtcc tggtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007470             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:24860:8596
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007470
VERSION     KCXD01007470.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:24860:8596"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65952.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          144 c          130 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actccataca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga cctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gactactggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01007471             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16722:14103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007471
VERSION     KCXD01007471.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16722:14103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65953.1"
                     /translation="CARSSSGTWLYWYFDTW"
     D_segment       432..437
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          148 c          138 g           91 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccgc
      121 tctgaggtcc agctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattct ccacgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggtgttgatc ctgcatatgg tgaaatgaca
      301 cacgcagaaa acttccaggg cagactcacc atgaccgagg acacgtctac agacacggcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tgtattattg tgcgagatca
      421 tccagcggta cgtggctata ctggtacttc gatacctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01007472             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:6648:11538
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007472
VERSION     KCXD01007472.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:6648:11538"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65954.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       430..436
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          114 a          139 c          153 g          100 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggagacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tcctgcaagt gatgaagtaa
      301 tacacgcaga tggtttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcggc ctgagatctg aggacacggc cgtgtattac tgtgcgagag
      421 ggaggttcgg tagtagcgtc tggtccaatc tcgtctatgg tttcgattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007473             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:23476:14654
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007473
VERSION     KCXD01007473.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:23476:14654"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65955.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       441..446
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       447..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          108 a          111 c          155 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccatagt gttccattcg gtgatcagca
       61 cagagcacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtatt tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttaaa tcgtttgatg
      301 gaactaagat atactacgca gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtttatt
      421 actgtgtgag agatgcctac gggagcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007474             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:7853:8690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007474
VERSION     KCXD01007474.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:7853:8690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65956.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       429..435
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          122 a          138 c          136 g           96 t
ORIGIN      
        1 acatgggggg atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aggtggtgca gtctggggct gaggtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacatctta accgaattat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata
      301 gacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagtagtct gagatctgag gacacggccg tgtattactg tgcgacatca
      421 tccagcggca cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01007475             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:19733:8350
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007475
VERSION     KCXD01007475.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:19733:8350"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65957.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       440..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          110 a          118 c          151 g          118 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt acctctggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg gctgacagtt atatcgtatg
      301 atgagactaa gaaatactac gcagactctg tgaaggaccg attcagcatc tccagagaca
      361 attccaagaa catggtatat cttcaaatga acaacctgaa attggaggac gcggccgtgt
      421 attactgtgc gagagattct tacggtcgag gctttgactc ctggggccag ggagtcccgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007476             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:16959:7286
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007476
VERSION     KCXD01007476.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:16959:7286"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65958.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       440..449
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          107 a          121 c          153 g          116 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgtggcta
      121 ttttaagagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcga cctctggatt caccttcagt cgctttggca
      241 tgcactgggt ccgccaggct ccaggggagg ggctggagtg ggtggcagtc atatcgtctg
      301 atgaaaataa caaatactac gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaacga catgttatat cttcacatga acgacctgaa attggaggac acggccgtgt
      421 attactgtgc gcgagacgtc tacggtagcg gacttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007477             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:20626:7244
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007477
VERSION     KCXD01007477.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:20626:7244"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..391
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65959.1"
                     /translation="CARDGIAAAGVDYW"
     D_segment       401..408
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           82 a          139 c          142 g           97 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc caggtgcagc tgctagagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggctat atcggtggtc ataatgggaa cacctactac aacccctccc tcacgagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgaagttga actctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gcgcgatggg atagcggcgg cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007478             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15211:17106
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007478
VERSION     KCXD01007478.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15211:17106"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    147..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        147..507
     V_segment       147..437
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65960.1"
                     /translation="CAKADTATPYYGLDSW"
     D_segment       441..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..507
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          110 a          138 c          151 g          110 t
ORIGIN      
        1 acatgggggg cagctctggg agaggagccc agcactgaaa gtccacagtg ttccattcgg
       61 tgatcagcac tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg
      121 ttgctatttt aagaggtgtc cagtgcgagg tgcagctggt ggagtctggg ggcggcctgg
      181 caaagcctgg gggagccctg agcctctcct gtgcagcctc tggattcacc ttcagtacct
      241 atgctatgca ctgggtccgc caggctccag ggaaggggct ggaatgggtc tcagctatta
      301 gtagtggtgg caccacatac tacgcagcct ccgtgaaggg ccgattcacc gtctccatag
      361 acaactcaaa gaacacactc tccctacaaa tgaacagcct gagaactgag gacacggccg
      421 tgttttactg tgcgaaagcc gatacagcta caccatacta cggtttggat tcctggggcc
      481 aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007479             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17365:17223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007479
VERSION     KCXD01007479.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17365:17223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65961.1"
                     /translation="CGRDDNGVLIDYW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          112 c          153 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 cttttttaag aggtgtccag tgtgaggtgc acctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg aagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgtaag taagaaatac tacgcagacg ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacacacta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgggagagat gataatgggg tgcttatcga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007480             311 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:13312:4768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007480
VERSION     KCXD01007480.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 311)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 311)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:13312:4768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..309
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..309
     V_segment       8..248
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <240..>278
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65962.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       252..262
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       268..309
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        310..>311
                     /gene="IGHG"
BASE COUNT           78 a           74 c           83 g           76 t
ORIGIN      
        1 acatggggag actctcctgt gcagcctctg gattcacctt cagtaactat ggcatgcact
       61 gggtccgcca ggctccaggg aaggggctgg attgggtggc agttatgtcg tttgatgaaa
      121 atgtgaaatt ctacgcagac tctgtgaagg accgattcac catctccaga gacaattcca
      181 agaacatgct atatcttcaa atgaacaacc tgaaattgga ggacacggcc ctgtattact
      241 gtgcgagagg ggaatacagt aattctattg acttctgggg ccagggagtc ctggtcaccg
      301 tctcctcagc c
//
LOCUS       KCXD01007481             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:16198:15202
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007481
VERSION     KCXD01007481.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:16198:15202"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    113..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        113..476
     V_segment       113..406
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <398..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65963.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       421..431
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           94 a          138 c          132 g          114 t
ORIGIN      
        1 acatggggta catgggaaat gctctctgag agtcatggac ctcctgtgca agaacatgaa
       61 gcacctgtgg ttcttccttc tcctggtggc aactcccaga tgggtcctgt cccaggtgca
      121 gctgcaggag tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc
      181 tgtctctggt gactccatcg gcaatagcta ctggatctgg atccgccagc ccccagggaa
      241 ggggctggag tggatagggt ctatctatgg tagtactggg agcacctttt acgacccctc
      301 cctcaagggt cgagtcaccg tttcaacaga cacgtccaag aacctatttt ccctgactct
      361 ggactctgtg accgccgcgg acaccgccgt gtattactgt gcgagatata gcgatactga
      421 tagttattac ttctttgact actggggcca gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007482             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:19862:10250
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007482
VERSION     KCXD01007482.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:19862:10250"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65964.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       431..435
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          124 c          157 g          111 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtcgggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcaac ttcaattact actacatgaa
      241 ctgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtatta acagtggtgg
      301 tgatagcaca taccaggcgg actccgtgaa gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatggacag cctgagaact gacgacacgg ctgtctatta
      421 ctgtgcgaga gtggtgggtg gtgccgcagg atacttcgac ttctggggcc agggcgccct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007483             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:5422:10825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007483
VERSION     KCXD01007483.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:5422:10825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..505
     V_segment       143..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65965.1"
                     /translation="CARVGDSDTTVTNFDYW"
     D_segment       453..462
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..505
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>511
                     /gene="IGHG"
BASE COUNT          115 a          121 c          152 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgctcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttac
      121 tatattaaga ggtgtccagt gtgaggtgca attggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gcagctttgg
      241 cattcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcac ttatatcgta
      301 tgatggaagt aagaagtact acgcagactc tgtgaagggc cgattcacca tctccagaga
      361 caattccaag aacatcctat atcttcaaat gaaccatctg aagttggagg acacggcctt
      421 ttattactgt gcgagggttg gggattcaga cactacagtt acgaactttg actactgggg
      481 ccagggagtc ctggtcaccg tctccccagc c
//
LOCUS       KCXD01007484             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:23352:6396
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007484
VERSION     KCXD01007484.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:23352:6396"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65966.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       437..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          106 a          124 c          159 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aggtggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 ctatgcactg ggtccaccag gctccaggga aggggctgga gtgggtctca gccattagtg
      301 ttggtggtag tacatattac gcagactccg tgaggggccg attcaccatc tccagagaca
      361 actcagagaa cacgctctcc ctgcaaatga acagcctgag agctgaggac acggccgtgt
      421 attactgtgc gaaaggggat acagctacag tttattacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007485             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10878:3421
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007485
VERSION     KCXD01007485.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10878:3421"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..460
     V_segment       107..395
                     /gene="IGHV4-150"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65967.1"
                     /translation="CASGGIAATGPDSW"
     D_segment       399..417
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           77 a          141 c          140 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tggatcctgt cccaagtgca gctgcgggag
      121 tcgggcccgg gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gtctccatca gcggttactg gtggggctgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt ttttcggtgg tagtcttggg gacccctact accactcctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaat aaccggttct ccctgaggct gacctctgtg
      361 accgccgcgg acacggccgt ttattactgt gcgagcgggg gtatagcagc gactggtccg
      421 gactcctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007486             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:18480:4625
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007486
VERSION     KCXD01007486.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:18480:4625"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65968.1"
                     /translation="CARDKGYSAVRRFDVW"
     D_segment       406..412
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..466
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           91 a          143 c          133 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gcctccatca gcagtaactc ctggaactgg atccgccagc ccccagggga gggactggag
      241 tggattggac gtatctctag tcttagtggg agcaccaact acaacccctc cctcacaagt
      301 cgagtcacca tttcaacaga cacgtccaag atccagatct ccctgaggct aagttctgtg
      361 accgccgcgg acacggccgt gtattactgt gcgagagata agggttacag tgcagttcga
      421 cggttcgatg tctggggccc gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007487             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:6197:5493
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007487
VERSION     KCXD01007487.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:6197:5493"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65969.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       446..452
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          117 c          149 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttcttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 atgatgaaag taagaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gcaattggag gacacggccg
      421 tgtattactg tgcgagagat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007488             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:6550:20289
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007488
VERSION     KCXD01007488.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:6550:20289"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65970.1"
                     /translation="CARDAGVGATILYYYDYW"
     D_segment       403..411
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           91 a          137 c          137 g          107 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc tcctgcactg tctctggtgg
      181 ctccttcagt ggttactact ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggttt atcggtggtg gtagtgggag caccgaatac aacccctccc tcaaaagtcg
      301 agtcaccatt tcaagagaca cgtccaaaaa tcaattctcc ctgaagctgg cctctatggc
      361 cgccgcggac acggccgttt atttctgtgc cagagatgcg ggagtgggag ccacaatcct
      421 ttactactat gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007489             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19008:7600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007489
VERSION     KCXD01007489.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19008:7600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..470
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65971.1"
                     /translation="CARDAGVGAIALYYYDFW"
     D_segment       403..408
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           93 a          135 c          139 g          105 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg tctctggtgg
      181 ctccttcagc ggttactact ggatctggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggggt atcggtggtg gtagtgggat caccgaatac aatccctccc tcaaaagtcg
      301 agtcactatt tcaagagaca cgtccaagaa ccaattctcc ctgaagctga gctctatgac
      361 cgccgcggac acggccgtat actactgtgc gagagatgcg ggagtggggg ccatagccct
      421 ttactactat gacttctggg gccagggagt cttggtcacc gtctcctcag cc
//
LOCUS       KCXD01007490             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:4900:15963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007490
VERSION     KCXD01007490.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:4900:15963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65972.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          112 c          152 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 accctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag ggtccaggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taggacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgata tttcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgtgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007491             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:22970:12223
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007491
VERSION     KCXD01007491.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:22970:12223"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..464
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65973.1"
                     /translation="CARDESAWNYPFDYW"
     D_segment       409..418
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           90 a          143 c          131 g          102 t
ORIGIN      
        1 acatggggga tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcctggtgg cagctcccag atgggtcctg tcccagctgc agctgcagga
      121 gtcgggccca ggaccggtga agccttcgga gaccctgtcc ctcacctccg ctgtctctgg
      181 tggctccatc agcactcact ggtggagctg gatccgccag ccccccggga agggactgga
      241 gtggattgga cgtatctctg gtactagtgg gaggactgac tacaacccct ccctcgagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttc tccttgaagt tgaattctgt
      361 gaccgccgcg gacacggccc tatattactg tgcgagagat gagtccgcct ggaactatcc
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007492             307 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:22030:9328
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007492
VERSION     KCXD01007492.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 307)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:22030:9328"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..304
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..304
     V_segment       7..231
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <224..>274
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65974.1"
                     /translation="CASGPSGSWNGWYFDFW"
     D_segment       238..253
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       256..304
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        305..>307
                     /gene="IGHG"
BASE COUNT           70 a           86 c           87 g           64 t
ORIGIN      
        1 acatggggtt tccggatcca ccttcaccga cttatccatg cactgggtgc gacaggcccc
       61 tggaaaaggg cttcagtgga tgggaagtgt tgatcctgca tatggtgaaa tgataaacgc
      121 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat
      181 ggagctgacc agcctgtcat ctgaggacac ggccgtgtat ttctgtgcga gtggccctag
      241 cggcagctgg aacggctggt acttcgattt ctggggccct ggcaccccaa tcaccgtctc
      301 ctcaacc
//
LOCUS       KCXD01007493             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:17327:3375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007493
VERSION     KCXD01007493.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:17327:3375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65975.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       451..456
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          106 a          128 c          156 g          119 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt ttccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agttaatgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg cagcctctgg attcagcttc agttactact
      241 acatgagctg ggtccgccag gctccaggga aggggctgga gtggatctca ggtcttaacg
      301 ctggtgggga taccacctac tatgcagact ccgtgaaggg cagatccacc atctccagag
      361 agaacgccaa gaacacactg caacttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgtgagagat cgacgtgttc agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007494             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:25726:10497
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007494
VERSION     KCXD01007494.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:25726:10497"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65976.1"
                     /translation="CATGPSGTWNAWCLDFW"
     D_segment       412..422
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          107 a          140 c          135 g           93 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgagggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccata cactgggtgc ggcaggcccc
      241 tggaaaaggg cttgagtgga tgggaagtgt tgatcctcta tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc tgcagacaca gcctacatgg aactgagtag
      361 tctgacattt gaggacacgg ccgtgtatta ctgtgcgact ggccctagcg gcacctggaa
      421 cgcctggtgc ctcgatttct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01007495             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:17650:12582
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007495
VERSION     KCXD01007495.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:17650:12582"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65977.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          118 a          112 c          150 g          119 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtaca attagtggag tctggaggag acttggttca
      181 gccggggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattattgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007496             465 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27121:19244
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007496
VERSION     KCXD01007496.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27121:19244"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..463
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..463
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>432
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65978.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       413..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..463
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        464..>465
                     /gene="IGHG"
BASE COUNT           91 a          139 c          127 g          108 t
ORIGIN      
        1 acatggggct ctctgagagt cttggacctc ctgtgcaaga acatgaagca cctgtggttc
       61 ttccttctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggcc tggtgaagcc ttcggagacc ctgtccctca cctgcgctgt ctctggtgac
      181 tccatcagca atagctactg gaactggatc cgccagcccc cagggaaggg gctggagtgg
      241 attgggtata tctctggtgc ttatgggagt accagctaca acccctccct caagagtcga
      301 gtcaccattt caactgacac gtccaagaac cagttttccc tgaggctggc ttctgtgacc
      361 gccgcggaca ccgccgttta ttactgtgtg agatatgagg acgaatccat aaactaccac
      421 tttgactact ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007497             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10750:9901
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007497
VERSION     KCXD01007497.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10750:9901"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..491
     V_segment       125..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65979.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       424..430
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          114 a          143 c          137 g           99 t
ORIGIN      
        1 acatggggag catcacacaa cagccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagctg caggcgcccg
      121 ctctgaggtc cagctggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc gaggtttccg gatacacctt caccgaactg tccatccact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg aagtgttgat cctgaatatg gtgaaatgat
      301 aaacgcagaa aacttccagg gcagagtcac cttgaccgag gacacgtcta caggaacggc
      361 ctacatggag ctgatcagcc tgagatctga agacacggcc gtgtattact gtgcgacatc
      421 acccagcggc aattggcttt tttggtactt cgatttttgg ggccctggca ccccaatcac
      481 catctcctca gcc
//
LOCUS       KCXD01007498             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8717:17377
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007498
VERSION     KCXD01007498.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8717:17377"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65980.1"
                     /translation="CATGRFGSSVWSSLFYGLDSW"
     D_segment       429..441
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          141 c          150 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtaaagg
      181 tctcctgcca ggtttccgga tacaccttca gtgaaatgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgctcc tggaaatggt gaaataatac
      301 acgcagagaa cttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagtagcctg agatctgagg acacggccgt gtattactgt gcgacaggga
      421 ggttcgggag cagcgtctgg tccagcctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcctca gcc
//
LOCUS       KCXD01007499             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:15896:12006
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007499
VERSION     KCXD01007499.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:15896:12006"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..497
     V_segment       119..410
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65981.1"
                     /translation="CATGRIGTSGWSNLFNGLDSW"
     D_segment       429..439
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          144 c          141 g           97 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc caacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccacctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccgtcaccga attatccatg cactgggtgc gacaggcccc
      241 tggacaaggg cttgagtgga tgggacttgt tgatcctgta aatggtgaac taatacacgc
      301 agacaagttc cagggcagag tcaccatgac cgaagacacg tctacagaca cagcctacat
      361 ggagttgagc agcctgacat ctgaggacac ggccatctac ttctgtgcga cagggaggat
      421 cggtaccagt ggctggtcca acctcttcaa tggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcttcagcc
//
LOCUS       KCXD01007500             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:13665:4950
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007500
VERSION     KCXD01007500.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:13665:4950"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65982.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       440..445
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          112 c          154 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agagcacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg ttcagccggg
      181 ggggtccctg agactctcct gtgaagcctc tggattcacc ttcagtattt ctggcatgca
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtg gcagttaaat cgtttgatgg
      301 aactaagata tactacgcag actctgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg ctatatcttc aaatgaacaa cctgaaattg gaggacacgg ccgtttatta
      421 ctgtgtgaga gatgcctacg ggagcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007501             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:19553:12773
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007501
VERSION     KCXD01007501.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:19553:12773"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..504
     V_segment       126..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65983.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       440..446
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          120 a          144 c          145 g           97 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccaactggtg cagtctgggg ctgaaatgaa gaagcctggg gcctcagtta
      181 gggtctcctg caaggtttcc ggaaacacct tcaccgaatt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gatgtgtcga tcctgcacaa ggtgaaataa
      301 tacacgcaga gaaattccag ggcagagtca ccatgaccga ggacacgtcc acagacacag
      361 ccttcatgga gttgagcagc ctgagatctg aggacacggc cgtgtatttc tgtgcgaaag
      421 gggggttcgg aaccagcgtc tggtccaacc tcttctacgg cttggattct tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007502             386 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:13629:6252
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007502
VERSION     KCXD01007502.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 386)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 386)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:13629:6252"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    24..384
                     /note="immunoglobulin heavy chain variable region"
     V_region        24..384
     V_segment       24..317
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <309..>353
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65984.1"
                     /translation="CARARGVIITYFDSW"
     D_segment       324..331
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       339..384
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        385..>386
                     /gene="IGHG"
BASE COUNT           84 a           90 c          125 g           87 t
ORIGIN      
        1 acatggggaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggtaa
       61 agcctggggg gaccctgaga ctctcctgcg cagcctctgg attcagcttc agttatttct
      121 acatgagttg ggtccgtcag gctccaggga aggggctgga gtggatctca agtattgaca
      181 atggtgggac taccgcaatt tatgcagact ccgtgagggg cagattcagc atctccagag
      241 agaacgccaa gaacacactg gatcttcaaa tggacagcct gagagctgag gacacggctg
      301 tctattattg tgcgagagca cgcggggtga tcattacata ctttgactcc tggggccagg
      361 gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007503             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:14983:11004
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007503
VERSION     KCXD01007503.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:14983:11004"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65985.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          116 c          152 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggaggcttg gttcgcccgg
      181 gggggtccct gagactctcc tgtgtagcct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttttg tcgtctgatg
      301 gaggttacaa ataccacgca gactctaaga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat cctatatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007504             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:15397:12224
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007504
VERSION     KCXD01007504.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:15397:12224"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..280
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..280
     V_segment       8..219
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <211..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65986.1"
                     /translation="CARDVYGWGLDYW"
     D_segment       228..234
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       239..280
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        281..>282
                     /gene="IGHG"
BASE COUNT           69 a           68 c           81 g           64 t
ORIGIN      
        1 acatgggcct tcagtagctt tggcatgcac tgggtccgcc aggctccagg gaaggggctg
       61 gagtgggtgg cagttatatc gtctgatgaa agtaagaaat actacgccga ctctttgaaa
      121 gaccgattca ccatatccag agacgactcc aggaacatgc tatatcttca actgaacaac
      181 ctgaaattgg acgacacggc cgtgtattac tgtgcgagag atgtgtatgg ctgggggctt
      241 gactactggg gccagggagt cctagtcacc gtctcctcag cc
//
LOCUS       KCXD01007505             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:15094:13082
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007505
VERSION     KCXD01007505.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:15094:13082"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65987.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           94 a          133 c          128 g          104 t
ORIGIN      
        1 acatggggga gagtcacgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctatcc ctcacctgcg ctgtctctgg tgactccatc
      181 agcagtagct actggaactg gatccgccag cccccaggga aggggctgga gtggattggg
      241 tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag tcgagtcacc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt gaccgccgcg
      361 gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta ccactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007506             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11527:6111
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007506
VERSION     KCXD01007506.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11527:6111"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65988.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       449..455
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          113 c          151 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tgttttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      301 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      361 caattccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007507             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:18474:10303
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007507
VERSION     KCXD01007507.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:18474:10303"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65989.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          115 a          144 c          130 g           93 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttcc ggatacacct taaccgacca ctacctacac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtattct tcctgagtat ggtaaagttg
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gactactggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01007508             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10489:13457
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007508
VERSION     KCXD01007508.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10489:13457"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65990.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          103 a          126 c          156 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac aaaccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta
      241 catgagctgg gtccgccagc ctccagggaa gggtctggag tggatctcag gtattaacgc
      301 tggtggggat ggcacatact ctgcagactc cgtgaagggc agattcacca tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agaactgagg acacggctgt
      421 ctatttctgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007509             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6698:17941
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007509
VERSION     KCXD01007509.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6698:17941"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65991.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          108 a          117 c          160 g          112 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gtggctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg ccaggctcca ggaaaggggc tagagtgggt ctcaactatt aatagtggtg
      301 gggataacac atattacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctcctcctg caaatgaaca gcctgagagt ggaggacacg gccgtgtatt
      421 actgtgttca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007510             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:23788:17483
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007510
VERSION     KCXD01007510.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:23788:17483"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65992.1"
                     /translation="CARDSYGRGFDSW"
     D_segment       443..449
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          119 c          150 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtggctgaca gttatatcgt
      301 atgatgagac taagaaatac tacgcagact ctgtgaaggg ccgattcacc atcttcagag
      361 acaattccaa aaacatgcta tatcttcaaa tgaacaacct gaaattggag gacgcggccg
      421 tgtattactg tgcgagagat tcttacggtc gaggctttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007511             370 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:25744:14308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007511
VERSION     KCXD01007511.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 370)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 370)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:25744:14308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    210..368
                     /note="immunoglobulin heavy chain variable region"
     V_region        210..368
     V_segment       210..298
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <290..>337
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65993.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       308..314
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       324..368
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        369..>370
                     /gene="IGHG"
BASE COUNT           79 a          102 c          103 g           86 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcaactggt gaccgtgccc tccagcagct tgggcaccca
      181 gacctacgtc tgcaacgtaa accacaagcc catctccaga gagaacgcca agaacacact
      241 gtctcttcac atggacggcc tgagacctga ggactcggct gtttattact gtgcgagaga
      301 tcgacgtgta cagtcgttat cctggttcga tgtctggggc ccgggagtcc tggtcaccgt
      361 ctcctcagcc
//
LOCUS       KCXD01007512             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12196:20394
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007512
VERSION     KCXD01007512.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12196:20394"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..509
     V_segment       137..429
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65994.1"
                     /translation="CTTHFGGNYYLDYFVYW"
     D_segment       444..458
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..509
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          115 a          124 c          143 g          129 t
ORIGIN      
        1 acatggggag aggagaccca gccttgggat ttccagctgt ctccacttgg tgatcagcac
       61 tgaacacagg agactcgcca tggagtttgt actgagctgg gttttccttg ttgctatatt
      121 aaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggaggcttgg tccagcctgg
      181 cgggtccctg agactctcct gtgcagcctc tggattcacc ttcagtgact atgccctgag
      241 ctgggtccgc caggcttctg ggaaaggact ggagtggatt ggctatatta gaagccaata
      301 taacaatttc gcgacagaat acgccccatc ggtgaaaggc agattcacca tctccagaga
      361 tgattcaaag aacacgctat ttctgcaaat gagtagcctg aaaaccgagg acacggccgt
      421 gtattactgc accacccatt ttggtggtaa ttattacttg gactactttg tctactgggg
      481 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007513             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:12512:9805
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007513
VERSION     KCXD01007513.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:12512:9805"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65995.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       445..450
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          113 c          161 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttcaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtgggtctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcgg ttatatcgag
      301 tgatgaaagt aagagatact acggagactc tgtgaaggac cgattcagca tttccagaga
      361 caactccaag aacatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattactgt gcgacagatg cgtttggtag cgggattgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007514             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:14947:15019
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007514
VERSION     KCXD01007514.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:14947:15019"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..476
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65996.1"
                     /translation="CARYGDDDYSGNDYFFDFW"
     D_segment       413..422
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       433..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           97 a          137 c          133 g          111 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtagct actggaattg gatccgccag tccccaggga agggactgga
      241 gtggattggg tacatctatg gtgctactgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcagc atttcaacag acacgtccaa gaaccagttt tccctgaacc tgaactctgt
      361 aaccgccgcg gacaccgccg tgtattactg tgcgagatat ggcgacgatg actatagtgg
      421 gaatgattac ttctttgact tctggggcct gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007515             310 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:24405:20316
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007515
VERSION     KCXD01007515.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 310)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 310)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:24405:20316"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    9..308
                     /note="immunoglobulin heavy chain variable region"
     V_region        9..308
     V_segment       9..223
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <215..>277
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65997.1"
                     /translation="CARGGFGSSVWSNLVYGLDSW"
     D_segment       232..239
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       263..308
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        309..>310
                     /gene="IGHG"
BASE COUNT           70 a           75 c           99 g           66 t
ORIGIN      
        1 acatggggac accttcaccg aattatccat gcactgggtg cgacaggccc ctggaaaagg
       61 gcttgagtgg atgggaggtg ttgaccctgg aaatggtgaa ataatacacg cagatagttt
      121 ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca tggagctgag
      181 cggcctgaga tctgaggaca cggccgtgta ttactgtgcg agaggggggt tcggtagcag
      241 tgtctggtcc aatctcgttt atggtttgga ttcctggggc caaggggtcg ccgtcaccgt
      301 ctcctcagcc
//
LOCUS       KCXD01007516             457 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6234:6706
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007516
VERSION     KCXD01007516.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 457)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 457)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6234:6706"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..455
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..455
     V_segment       101..389
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>424
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65998.1"
                     /translation="CGNGARRTLGDYW"
     D_segment       390..394
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       416..455
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        456..>457
                     /gene="IGHG"
BASE COUNT           79 a          138 c          139 g          101 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcacg aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccagatg ggtcctgtcc cagatgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattgggtat atcggtggta ctagtgggag caccttctac aacccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttctcc ctgatgctga cctctgtgac
      361 cgccgcggac acggccgtct atttttgtgg taacggggcc cgacgtactt tgggggacta
      421 ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007517             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6138:12537
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007517
VERSION     KCXD01007517.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6138:12537"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..490
     V_segment       124..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX65999.1"
                     /translation="CAAGYSGSWNHWYFDLW"
     D_segment       418..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..490
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>492
                     /gene="IGHG"
BASE COUNT          115 a          147 c          136 g           94 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcatagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagcaac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaagtgaaga agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgaattat ccattcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga ggcgttgatc ctgcatatgg tgagtttaca
      301 cccggagaga agctccaggg cagagtcacc atgaccgaag acacgtctat agacacagcc
      361 tacatggagc tgagcagcct gaattctgac gacacggccg tctattactg tgctgccggg
      421 tatagcggca gctggaacca ctggtacttc gatctctggg gccctggcac cccaatcacc
      481 atctcctcag cc
//
LOCUS       KCXD01007518             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15535:3265
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007518
VERSION     KCXD01007518.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15535:3265"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..461
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66000.1"
                     /translation="CARYEEGGTTFDYW"
     D_segment       410..414
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           91 a          137 c          134 g          101 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc cttacctgcg ctgtctctgg
      181 tgactccatc accagtagat actggggctg gatccgccag cccccaggga agggactgga
      241 gtggattgga tatatctatg gtggcagtgg gagcaccggc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaccag acacgtccaa gaaccagttt tccctgaagc tgaagtctgt
      361 gaccgccgcg gacaccgccg tatatttctg cgcgcgatat gaagagggcg gaaccacctt
      421 tgactactgg ggcctgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007519             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:24736:12486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007519
VERSION     KCXD01007519.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:24736:12486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66001.1"
                     /translation="CARGVTADVFGFLGLDYW"
     D_segment       421..427
                     /gene="IGHD4-22"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          140 c          145 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctcccctc cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccacctggtg cagtctgggg ctgaagtgaa gaagcctggg gcctcagtga
      181 aggtctcctg caaagtttcc ggatacacct tcaccgattt atccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtggatgg gaggtgttga tactgtatct gatggagtga
      301 tatacgcaga gaacttccag ggcagagtca ccatgaccga ggacacgtct acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtttattac tgtgcgagag
      421 gtgtgacagc agacgtcttc ggtttcctcg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007520             458 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:15262:22604
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007520
VERSION     KCXD01007520.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:15262:22604"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..456
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..456
     V_segment       102..398
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <390..>425
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66002.1"
                     /translation="CARWSAANFDYW"
     D_segment       403..409
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       412..456
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        457..>458
                     /gene="IGHG"
BASE COUNT           86 a          137 c          135 g          100 t
ORIGIN      
        1 acatgggggg ttctctggga gtcacggacc tcctgggcaa gaacatgaag catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcaa tagtggttat ggctggagct gggtccgcca gcccccaggg aaggggctgc
      241 agtggattgg ccatttctac gatagtagtg ggaacaccta ctaccacccc tccctcaaga
      301 gtcgagtcac catttcaaaa gagacgtcca agaaccagtt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtgtattatt gtgcgagatg gtcggcagcc aactttgact
      421 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007521             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:22816:19553
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007521
VERSION     KCXD01007521.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:22816:19553"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..496
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66003.1"
                     /translation="CARGPPTEGGDYSGGALSRW"
     D_segment       431..442
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          134 c          149 g          101 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctatgtca tcaattgggt gcgacaggcc
      241 cctggacaag ggctagagtg gatgggaggg atcatccctc ttgttggtac aacaaactac
      301 gcacagaagt tccagggcag agtcacgatt attgcggaca cgtccacaag cacagcctac
      361 atggaattga gaagcctgag atctgaggac acggccgtgt attactgtgc gagaggcccc
      421 cctactgaag ggggtgatta ttctgggggg gctttgagtc gatggggcca gggagtccag
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007522             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:14758:19609
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007522
VERSION     KCXD01007522.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:14758:19609"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..479
     V_segment       101..408
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <401..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66004.1"
                     /translation="CASADSGYPPYFFDFW"
     D_segment       415..424
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT           82 a          141 c          140 g          118 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtctgtc acctgcgctg tctctggtgt
      181 ctctatcacc agtaccaact ggtgctggat ccgccaggcc ccagggaagg gactggagtg
      241 gattgggtgt ttctgtggtg gtggtatctt tggtggtagt agtaacaccc agtacagtcc
      301 ctccctcaag agtcgagtca ccctgtcagt agacgcgtcc aagaaccaac tctccctgca
      361 gctgacgtct gtgaccgccg cggacacggc cgtgtatttc tgtgcgagcg ctgatagtgg
      421 ttatcctccc tacttctttg acttctgggg ccagggagtc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01007523             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:11056:16726
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007523
VERSION     KCXD01007523.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:11056:16726"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..434
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <433..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66005.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       449..462
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          114 a          126 c          156 g          120 t
ORIGIN      
        1 acatgggggt gggagaggag acccagcctt gggatttcca gctgtctcca cttggtgatc
       61 agcactgaac acaggagact cgccatggag tttgtactga gctgggtttt ccttgttgct
      121 atattaaaag gtgtccagtg tgaggttcag ctggtggagt ctgggggagg cttggtccag
      181 cctggcgggt ccctgagact ctcctgtgca gcctctggat tcagcttcag tgactatggc
      241 atgagctggg tccgccaggc ctctgggaaa ggactggagt gggttggcta cattagaagc
      301 acacatagga attacgcgac ggaatacgcc gcatcggtga aaggcagatg caccatctcc
      361 agagatgact caaagaacac actatatctg caaatgagca gcctgagaac cgaggacacg
      421 gccgtgtatt actgcaccac cctctatggt ggtagttatt acgtggacta ctttgactcc
      481 tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007524             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:14168:13960
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007524
VERSION     KCXD01007524.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:14168:13960"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66006.1"
                     /translation="CATGRIGSSGWSNLFTGLDSW"
     D_segment       431..440
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          115 a          143 c          146 g           98 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccac ctggtgcagt ctggggctga ggtgaagcag cctggggcct cagtgaaggt
      181 ctcctgtaag gtttccggat acaccgtcac cgaattatcc atgcactggg tgcgacaggc
      241 ccctgggaaa gggcttgagt ggatgggagt tgttgatcct gtcaatggtg aagaaataca
      301 cgcagagaag ttccagggca gagtcaccat gaccgaggac acgtcgacag acacagccta
      361 tatggacttg accagtctca gatctgagga cacggccatc tattactgtg cgacagggag
      421 gatcggtagt agcggctggt ccaacctctt caccggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007525             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:15829:4831
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007525
VERSION     KCXD01007525.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:15829:4831"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..501
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66007.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       421..434
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>507
                     /gene="IGHG"
BASE COUNT          114 a          138 c          146 g          109 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccacc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata caccttcagc atctctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgggtg gatgggaggg atcatccctc ttgttggtat gacaaactac
      301 gaacagaagt tccagggcag agtcacgatt accgcggaca cgtccacgaa tacagtcttc
      361 atggaactga gcagcctgag atctgaggac acggccgtct actattgtgc gacaggggta
      421 tattaccagg atgaaaacgg ttatttttat gtcggcggtg actttgacta ctggggccag
      481 ggagtcctgg tcaccgtctc cccagcc
//
LOCUS       KCXD01007526             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:7541:17556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007526
VERSION     KCXD01007526.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:7541:17556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66008.1"
                     /translation="CTRDAFGSGCDYW"
     D_segment       448..457
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          115 a          118 c          151 g          116 t
ORIGIN      
        1 acatgggggg ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 ggccgggggg gtccctgaga ctctcctgta cagtctctgg attcaccttc aatacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcga
      301 gtgatgaaac taagaaatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gaaattggag gacacggccc
      421 tttattactg tacgagagac gcatttggca gcggctgtga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007527             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14242:10480
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007527
VERSION     KCXD01007527.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14242:10480"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..399
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <391..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66009.1"
                     /translation="CARDEDPSIFDHW"
     D_segment       410..414
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           90 a          136 c          132 g          104 t
ORIGIN      
        1 acatggggag gttctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctct tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggcgccatca gcaggggttt ctactggacc tggatccgcc aacccccagg gaaggggctg
      241 gagtggattg ggtgtatcgg tggtagtagt ggtaccacct attataaccc ctccctcaag
      301 agtcgagcct ccatttcaaa agacacgtcc aacaatcaac tctccctgaa gctgagttct
      361 gtgaccgtcg cggacacggc cgtgtattac tgtgcgagag atgaagaccc ctccattttt
      421 gaccactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007528             484 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:20636:6948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007528
VERSION     KCXD01007528.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 484)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 484)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:20636:6948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..482
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..482
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>451
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66010.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       399..420
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..482
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        483..>484
                     /gene="IGHG"
BASE COUNT           99 a          134 c          138 g          113 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtgcgag aacatgaagt atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagt tgcaggagtc
      121 gggcccagga ctgatgaagc cttcagagac cctgtccctc agctgcgctg tctctggtgg
      181 ctccataagt ggtaactggt ggagctggat ccgtcagccc ccagggaagg gactggactg
      241 gattggacgt atctctggta ctagtgggga caccaattac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccacttctcc ctgaagctga actctgtgac
      361 cgccgcggac gcggccgtgt attattgtgc aagagcggat tacgaggatg attacggtta
      421 tcatttagga tacaactggt tcgatgtctg gggcccggga gtcctggtca ccgtctcctc
      481 agcc
//
LOCUS       KCXD01007529             416 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:10316:17661
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007529
VERSION     KCXD01007529.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 416)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 416)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:10316:17661"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    33..414
                     /note="immunoglobulin heavy chain variable region"
     V_region        33..414
     V_segment       33..326
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <318..>383
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66011.1"
                     /translation="CARADYEDDYGYHLGYNWFDVW"
     D_segment       331..352
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       364..414
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        415..>416
                     /gene="IGHG"
BASE COUNT           87 a          117 c          120 g           92 t
ORIGIN      
        1 acatgggggc agctcccaga tgggtcctgt cccagctgca gttgcaggag tcgggcccag
       61 gactgatgaa gccttcagag accctgtccc tcagctgcgc tgtctctggt ggctccataa
      121 gtggtaactg gtggagctgg atccgccagc ccccagggaa gggactggac tggattggac
      181 gtatctctgg tactagtggg gacaccaatt acaatccctc cctcaagagt cgagtcacca
      241 tttcaacaga cacgtccaag aaccacttct ccctgaagct gaactctgtg accgccgcgg
      301 acgcggccgt gtattattgt gcaagagcgg attacgagga tgattacggt tatcatttag
      361 gatacaactg gttcgatgtc tggggcccgg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007530             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:19935:17086
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007530
VERSION     KCXD01007530.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:19935:17086"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66012.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       431..446
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          103 a          124 c          158 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcaggtgg tggagtctgg gggcggcttg gcaaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcagtacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagccatt agtgttggtg
      301 gtagtacata ctacgcagac tccgtgaggg gccgattcac catctccaga gacaactcag
      361 agagcacgct ctccctgcaa atgaacagcc tgagtactga ggacacggcc gtgtattact
      421 gtgccaaagg ggatacagct acagtttatt acggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007531             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:17105:8693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007531
VERSION     KCXD01007531.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:17105:8693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66013.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          118 a          143 c          145 g           98 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaagg agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 cacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007532             492 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:19908:10565
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007532
VERSION     KCXD01007532.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:19908:10565"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..489
     V_segment       124..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>459
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66014.1"
                     /translation="CASGPSGSWNGWYFDIW"
     D_segment       423..438
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>492
                     /gene="IGHG"
BASE COUNT          116 a          145 c          137 g           94 t
ORIGIN      
        1 acatggggac atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gacgtgaaga agcctggggc ctctgtgaag
      181 gtctcctgca aggtttccgg atacaccttc accgagttat ccatacactg ggtgcgacag
      241 gcccctggaa aagggcttca gtggatggga agtgttgatc ctgcatatgg tgaaatgata
      301 aacacagaga agttccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcagcct gagatctgag gacacggccg tctatttctg tgcgagtggc
      421 cctagcggca gctggaacgg ctggtacttc gatatctggg gccctggcac ccctatcacc
      481 gtctcctcaa cc
//
LOCUS       KCXD01007533             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:10837:13747
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007533
VERSION     KCXD01007533.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:10837:13747"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..495
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66015.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       439..447
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>499
                     /gene="IGHG"
BASE COUNT          113 a          112 c          158 g          116 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccggt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gttactatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaagt aagaaatact acggagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacaggctat atcttcaaat gaacaacctg aaattggagg acacggcagt
      421 gtattactgt gcgagagatg atagtggggt gatcatcgac tactggggcc agggagtcct
      481 ggtcaccgtc tcctccgcc
//
LOCUS       KCXD01007534             524 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:6254:11308
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007534
VERSION     KCXD01007534.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 524)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 524)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:6254:11308"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..522
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..522
     V_segment       144..443
                     /gene="IGHV3-172"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <435..>491
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66016.1"
                     /translation="CAREAYSWNNLYFYGLDSW"
     D_segment       450..464
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..522
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        523..>524
                     /gene="IGHG"
BASE COUNT          113 a          126 c          163 g          122 t
ORIGIN      
        1 acatgggggc tctgggagaa gagaccccgc ctgggattcc caggagtttc cacctggtga
       61 tcagcactga acacaaacca ccagccatgg agtttgggct gagctgggtt ttccttgttg
      121 ctatttggaa aggtgtccag tgtgaggtgc agctggtgga gtccggggga ggcttggtcc
      181 agcctggcgg gtccctgagc ctctcctgtg cagcctctgg attcaccttc agtgattctg
      241 gtatggactg ggtccgccag gctccaggaa aggggctgga gtgggtaggt ttcattagaa
      301 gcaaaactta tggtgggaca gcagaatact ccgcgtctgt gaagggcaga ttcaccatct
      361 ccagagatga ttcaaagaac acggcgtatc tgcagatgac cagcctgaaa accgaggaca
      421 cggccgtata ttactgtgct agagaggcgt atagttggaa caacctatat ttctacggtt
      481 tggattcctg gggccaaggg gtcgtcgtca ccgtctcctc agcc
//
LOCUS       KCXD01007535             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:21725:9131
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007535
VERSION     KCXD01007535.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:21725:9131"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..497
     V_segment       125..417
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66017.1"
                     /translation="CASGPTTIFGMLVTGLDFW"
     D_segment       427..439
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          143 c          135 g          104 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcaacta caggcgccca
      121 ctctgaggtc cagctggtgc agtctgggtc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gatacacctt caccgaattc tccatgcact gggtgcgaca
      241 ggcccctgga caagggcttg agtggatggg agttgttgat cctttggata atgaaataat
      301 atacgcagac aacttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggaa ctgagcagcc tgacctctga cgacacggcc atctattact gtgcgagtgg
      421 gcctactaca atttttggaa tgcttgttac ggggcttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007536             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:7886:5291
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007536
VERSION     KCXD01007536.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:7886:5291"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66018.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       419..427
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       460..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          113 a          140 c          144 g           99 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat tgactggacc tggaggatcc tcctcttgtg gcagcagcta caggcgccca
      121 ctctgaggtc cagttggtgc agtctggggc tgaagtgagg aagcctgggg tctcagtaaa
      181 ggtctcctgc aaggtttccg gaaacaccat caccgaatta tccgtgcact gggtgcgaca
      241 ggcccctgga aaaggccttg agtggatggg gggtgttgat cccgtctatg gtgaaataag
      301 acacgcagag aacttccagg gcagagtcac catgaccgag gacacgtcga cagacacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtctattact gtgcgcgagg
      421 atattgtcat ggtagttact gttcctcggg tcttgtctcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01007537             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:22370:17928
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007537
VERSION     KCXD01007537.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:22370:17928"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..475
     V_segment       103..399
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <391..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66019.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       405..424
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..475
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT           92 a          138 c          137 g          110 t
ORIGIN      
        1 acatggggat gttctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacatgcgc tgtctctggt
      181 ggctccatca gcagtagtac ctggtggaac tgggtccgcc agcccccagg gaaaggcctg
      241 gagtggatag gatatatcaa tggtgagagt ggtagcacct actacaatcc ctccctcgag
      301 agtcgaatca ccatttcaac agacacgtcc acgaaccagt tttccctgag gctgagctct
      361 gtgaccgccg cggacacggc cgtgtatttc tgtgcgagag gttcctatag tggtagttat
      421 tacttcaacc ggttcgatgt ctggggcccg ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007538             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:15279:2381
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007538
VERSION     KCXD01007538.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:15279:2381"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66020.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           93 a          136 c          127 g          112 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agttcccaga tgggtcctgt cccaggtgca gctgctggag
      121 tcgggcccgg gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcactagtta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccactttt ccctgaggct gagttctgtg
      361 acctccgcgg acaccgccgt gtattattgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007539             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:10009:7448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007539
VERSION     KCXD01007539.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:10009:7448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..499
     V_segment       142..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66021.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       440..445
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..499
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          112 a          111 c          154 g          124 t
ORIGIN      
        1 acatgggggt ctgggagagg agcccagccc tggaagacca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgaa gcctctggat tcgccttcag tagttttggc
      241 tttcactggg tccgccaggc tccagggaag gggctggagt gggtggcagt tatatcgtac
      301 gatgaaaata agaaatatta cgcagactct ctgaaggacc gattcaccat ctccagagac
      361 aattccaaga acatggttta tcttcaaatg aacaacctga aattggagga cacggccgtt
      421 tattactgtg cgaggaggcc ctggagtgca gatgcttttg atttctgggg ccgaggactc
      481 agggtcaccg tctcttcagc c
//
LOCUS       KCXD01007540             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:17468:11253
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007540
VERSION     KCXD01007540.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:17468:11253"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..465
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66022.1"
                     /translation="CARYEDDSGYYYFDSW"
     D_segment       409..421
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>469
                     /gene="IGHG"
BASE COUNT           91 a          133 c          129 g          116 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacttga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agttgcagga
      121 gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcatctgcg ctgtctctgg
      181 tgcctccatc accagtagct tctggagctg gatccgacag cccccaggga agggactgga
      241 gtggattggc tatatctatg gtagtactgg gagtagcagt tccaatccct ccctcaagag
      301 tcgagtcacc atttcaacgg acacgtccaa gaaccagttt tccctgaaac tgagctctgt
      361 gaccgccgcg gacaccgcct tttatttctg tgcgagatat gaagatgata gtggttatta
      421 ctactttgac tcctggggcc agggagtcct ggtcaccgtc tcctcggcc
//
LOCUS       KCXD01007541             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:14033:16734
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007541
VERSION     KCXD01007541.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:14033:16734"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..469
     V_segment       115..408
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66023.1"
                     /translation="CVRDSYGSGLDAW"
     D_segment       415..427
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       428..469
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          108 a          102 c          143 g          118 t
ORIGIN      
        1 acatgggagt ccacagtgtt ccattcggtg atcagcacag aacacagagg actcaccatg
       61 aagttagggc tgagctgggt tttccttgtt gctattttaa gaggtgtcca gtgtgaggtg
      121 cagctggtgg agtctggagg aggcttggtt cagcctgggg ggtccctgag actctcctgt
      181 gaagcctctg gattcacctt cagtagtaat ggcatgcact gggtccgcca ggttccaggg
      241 aaggggctgg agtgggtggc agttatatcg tatgatgtaa gtaagaaata ctacgcagac
      301 tctgtgaagg accgattcac catctccaga gacaattcca agaacatgct atatcttcaa
      361 atgaacaacc tgaaattgga ggacacggcc gtgttctact gtgtgagaga ctcttatggg
      421 agtggtttgg atgcctgggg ccaaggggtc gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01007542             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:5848:14451
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007542
VERSION     KCXD01007542.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:5848:14451"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..507
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66024.1"
                     /translation="CARVGTYDSGYYTFDYW"
     D_segment       452..464
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       465..507
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          116 a          114 c          153 g          126 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccagtgt gaggtacaac tggtggagtc tggaggaggc ttggttcagc
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt ggctatggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggaatg ggtggcactg atatcgtatg
      301 atggaagtaa ggaatactat gcagactctg tgaaggaccg attcaccatc tccagagaca
      361 attccaagaa catgctttat tttcaactgc acaacctgaa attggaggac acggccatgt
      421 attactgtgc gagagtgggg acatatgata gtggttatta tacctttgac tactggggcc
      481 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007543             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21236:9719
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007543
VERSION     KCXD01007543.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21236:9719"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66025.1"
                     /translation="CAREWIQWTQLVSGLDSW"
     D_segment       440..452
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..513
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          117 a          112 c          164 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agatggtgga gtctggagga ggcttggttc
      181 agcctggggg gtcactgaga ctctcctgtg taggctctgg attcagtttc aatacctatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtcatatcgt
      301 ttgatggaag taagaagtac tacgcagact ctgtgaagga ccgactcacc atctccagag
      361 acaattccaa gagtacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggag tggatacagt ggacacagtt agtgagcggt ttggattcct
      481 ggggccaagg ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01007544             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:6290:5802
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007544
VERSION     KCXD01007544.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:6290:5802"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66026.1"
                     /translation="CARRPFGSDAFDFW"
     D_segment       447..453
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          113 a          115 c          152 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga aatttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtcactatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgc
      301 atgatgaaaa taaggaatac tacgtagact ctgtgaaggg ccgattcacc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacct gcaattggag gacacggccg
      421 tgtattattg tgcgagacga ccgttcggta gtgatgcttt tgatttctgg ggccaagggc
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01007545             486 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:4123:10954
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007545
VERSION     KCXD01007545.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 486)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 486)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:4123:10954"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..484
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..484
     V_segment       112..408
                     /gene="IGHV4-144"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>453
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66027.1"
                     /translation="CARVDYSGNYYFHRFDVW"
     D_segment       413..433
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..484
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        485..>486
                     /gene="IGHG"
BASE COUNT          102 a          142 c          133 g          109 t
ORIGIN      
        1 acatggggac atgggaaatg ctctctgaga gttacggaca tcctgtgcaa gaacatgaag
       61 cacctgtggt tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgaaa
      121 cttcagcagt ggggcgaagg actggtgaag ccttcggaga ccctgtccct cacctgcgct
      181 gtctctggtg gctccatcag cggtgactac tactggagct ggatccgcca gccccccggg
      241 aaggggctgg agtggattgg atatatctat gctgatagtg cgaccaccaa ctacaacccc
      301 tccctcaaca atcgagtcac catttcaaaa gacacgtcca agaaccagtt ctccctgaag
      361 ctgagctctg tgaccgccgc ggacacggcc gtgtattact gtgcgagagt ggactatagt
      421 ggtaattatt acttccaccg cttcgatgtc tggggcccgg gagtcctggt caccgtctcc
      481 tcagcc
//
LOCUS       KCXD01007546             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:12971:14961
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007546
VERSION     KCXD01007546.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:12971:14961"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..430
                     /gene="IGHV3-53"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66028.1"
                     /translation="CARERFGGIGVIIYSWVDFW"
     D_segment       448..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          107 a          124 c          164 g          119 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttc ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagccggg
      181 ggggtccctg agactctcct gcgcagcctc cggattcacc ttcagtgact tctacatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgtatta atcatgacgg
      301 tggtaacaca tggtacgcag actccgtgag gggcagattc accatctcca gagagaacgc
      361 caagaacaca ctgtatcttc aaatagacag gctgagacct gaggacacag ccgtgtattt
      421 ctgtgcgaga gagcggtttg ggggaattgg ggtgattatc tacagctggg tcgatttctg
      481 gggcccggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007547             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:16270:6448
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007547
VERSION     KCXD01007547.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:16270:6448"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66029.1"
                     /translation="CARDVRGTGFDYW"
     D_segment       447..452
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          117 a          117 c          149 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag agaagtccaa tgtgaggtgc acctggtgga atctggagga ggttcggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtacctttg
      241 gcattcactg ggtccgccag gctccgggga aggggctgga gtgggtggca gttatatcgt
      301 atgatgaaac taagacatac tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa caacatggta tatcttcaaa tgaacaacct gaaattagag gacacggccg
      421 tgtattactg tgcgagagat gtcaggggaa cggggtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007548             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20238:7296
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007548
VERSION     KCXD01007548.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20238:7296"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66030.1"
                     /translation="CARDDFGSGLGYW"
     D_segment       447..455
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          112 a          111 c          158 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcagcttca gtatctttgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatgtcgaa
      301 tgatggaagt aagaaatact acacagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aaaatgctat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtattattgc gcgagagacg attttggcag cggcttaggg tactggggcc agggagccct
      481 ggtgaccgtc tcttcagcc
//
LOCUS       KCXD01007549             477 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:22437:21608
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007549
VERSION     KCXD01007549.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:22437:21608"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..475
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..475
     V_segment       121..400
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <394..>444
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66031.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       418..426
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..475
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        476..>477
                     /gene="IGHG"
BASE COUNT          112 a          141 c          132 g           92 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct ttggtggcag caactacagg cgcccactct
      121 gaggtccttc tggtgcagtc tggggctgaa atgatgcagc ctggggcctc agtgaaggtc
      181 tcctgcaagg tttccggaaa caccttcacc gaattgtcca tgcactgggt gcgacaggcc
      241 cctggaaaag ggcttgagtg ggtgggaagt gttgatcctg catatggtga aatgacgttc
      301 cagggcagag tcaccatgac cgaggacacg tctacagaca cagcctacat ggaactgagc
      361 agcctgacat ctgaggacac ggccgtgtat tactgcgcga ttggccctag tggcagatgg
      421 aacgactggt ccttcgacat ctggggacct ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01007550             447 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:23465:8692
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007550
VERSION     KCXD01007550.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 447)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 447)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:23465:8692"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    79..445
                     /note="immunoglobulin heavy chain variable region"
     V_region        79..445
     V_segment       79..371
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <364..>414
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66032.1"
                     /translation="CARSDSGSWNGWYLDLW"
     D_segment       377..393
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..445
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        446..>447
                     /gene="IGHG"
BASE COUNT          103 a          118 c          135 g           91 t
ORIGIN      
        1 acatggggac agcacctcac catggactgg acctggagga tcctcctctt ggtggcagca
       61 gctacaggcg cccagtctga ggtccagctg gtgcagtctg gggctgaggt gaagaagcct
      121 gggacctcag tgaaggtctc ctgcaaggtt tccggataca ccttcaccga attatccgtt
      181 cattgggtgc gacaggcccc tggaaaaggg cttgagtgga tgggaagtat tgatcctcta
      241 tatggtgaaa tgatacacac agagaagttc cagggcagag tcaccatgac cgaggacacg
      301 tctacagata cagcctacat ggagctgagg agcctgagat ctgacgacac ggccgtgtat
      361 tactgtgcga ggtcggatag cggcagttgg aacggctggt acctcgatct ctggggccct
      421 ggcaccccaa tcaccatctc ctcagcc
//
LOCUS       KCXD01007551             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18979:6888
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007551
VERSION     KCXD01007551.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18979:6888"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..468
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66033.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       408..415
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..468
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           89 a          148 c          127 g          106 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggaca tcctgtacaa gaacatgcag tttctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccagctgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcagaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag tcgtaactgg tggagttggg tccgccagcc cccaggcaag ggactggagt
      241 ggattggacg tatctctggt agtcttggaa gcaccagtta caatccctcc ctcgagagtc
      301 gagtcaccat ttcaagagac acgtccagga accagttctc cctgaagctg acctctgtga
      361 ccgccgcgga cacggccgtg tatttctgtg cgagacattc agaccccgca actactagct
      421 ggtacttcga tctctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01007552             410 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:18890:6151
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007552
VERSION     KCXD01007552.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 410)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 410)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:18890:6151"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    65..408
                     /note="immunoglobulin heavy chain variable region"
     V_region        65..408
     V_segment       65..327
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <324..>377
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66034.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       343..350
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       364..408
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        409..>410
                     /gene="IGHG"
BASE COUNT           92 a          110 c          116 g           92 t
ORIGIN      
        1 acatgggctg ggaagtatgt acacggggtg cgggccaagc atcctcgtgc caccccgaga
       61 gcccgggagg cttggtacag cctggggcgt ccctgagact ctcctgtgca gcctctgaat
      121 tcaccttcag tggctatgac atgcactggg ttcgccaggc tccagggaag ggtctagaat
      181 gggtatcagg tattaacatt ggcggtgacc catactaccc agactctgtg cagggtcgat
      241 tcaccatctc cagagacaac gccaagaact ccttgtatct tcaaatgaac aacctgagac
      301 ctgaggacac tgctgtgtat tattgtgtga gggggatgga taactaccac ttcagtaata
      361 cggactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007553             334 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:8271:13690
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007553
VERSION     KCXD01007553.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 334)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 334)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:8271:13690"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..332
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..332
     V_segment       8..255
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>301
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66035.1"
                     /translation="CARGIDNYHYSDTDFDYW"
     D_segment       273..281
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       288..332
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        333..>334
                     /gene="IGHG"
BASE COUNT           78 a           82 c           92 g           82 t
ORIGIN      
        1 acatgggggg gcgtccctga gactctcctg tgcggcctct gaattcacct tcagcagcta
       61 tgacatgcac tgggttcgcc aggctccagg gaagggtctg gagtgggtat caggtattaa
      121 cattggcggt gacacatact acccagactc tgtgaagggt cgattcacta tctccagaga
      181 caatgccaag aactccttgt atcttcaaat gaacagcctg agagttgagg acactgctgt
      241 gtatttttgt gcaaggggga tagataacta ccactatagt gatacggact ttgactactg
      301 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007554             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16944:15269
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007554
VERSION     KCXD01007554.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16944:15269"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66036.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          104 a          113 c          157 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggtttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtatc tctggcatgc
      241 actgggtccg ccaggctcca gggcaggggc tggattgggt ggcagttgaa tcgtttgatg
      301 gaggtaagaa atactacgct gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt caaatgagca acctgaaatt ggaggacacg gccgtgtatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007555             515 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:23631:4624
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007555
VERSION     KCXD01007555.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:23631:4624"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..513
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..513
     V_segment       144..440
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <432..>482
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66037.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       451..465
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..513
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        514..>515
                     /gene="IGHG"
BASE COUNT          109 a          124 c          154 g          128 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctatattaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtgactact
      241 ggatgtactg ggttcgccag acacctgagc ggggcctgga gtggatctca gctattgata
      301 gtgctgttac tagtaccaca tactatgcag actccgtgaa gggcagattc accatctcca
      361 gagagaacgc caaaaacaca ctgtatcttc agatggacag cctgagaact gaggacacgg
      421 ctgtctatta ctgtgcgaga gttccgggcc tagtggtatt tactggttcg cttgactact
      481 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007556             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:17732:4315
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007556
VERSION     KCXD01007556.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:17732:4315"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66038.1"
                     /translation="CARTTSRGLVFDFW"
     D_segment       397..401
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..458
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           90 a          139 c          128 g          103 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcacc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccttcagc agttactggt ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gcttggggag atcaatggta atagcggaac caccaactac aatccctccc tcaagagtcg
      301 agtcaccatt tcaaaagacg cgtccaagaa tcagttctcc ctgaacctaa attctgtgac
      361 cgccgcggac acggccgtct atttctgtgc gaggaccacc tcccggggac ttgtttttga
      421 tttctggggc caagggctca gggtcaccgt ctcttcagcc
//
LOCUS       KCXD01007557             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:23130:9640
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007557
VERSION     KCXD01007557.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:23130:9640"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66039.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       440..446
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          101 a          124 c          156 g          121 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact acttcatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtattt ccagtggtgg
      301 ggatagcaca tactctgcag actccgtgaa gggcagattc accatttcca gagagaacgc
      361 caagaccaca ctgtatcttc acatggacag cctgagagct gaggacacgg ctgtctatta
      421 ctgtgcaaga gatcgacgtg tacagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007558             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:11736:10316
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007558
VERSION     KCXD01007558.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:11736:10316"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..485
     V_segment       122..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66040.1"
                     /translation="CAAADSGYPFYYFDIW"
     D_segment       413..419
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          121 a          141 c          126 g           99 t
ORIGIN      
        1 acatggggaa cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggaa ccaccttcac cgaattatcc ctgcactggg ttcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag ttttaatact atatatggtg aaattttaca
      301 cacagagaag ttccagggca gagtcaccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga catctgagga cacggccgtg tattactgtg cggcagctga
      421 tagtggttac ccattttact acttcgatat ctggggccct ggcaccccaa tcaccatctc
      481 ctcagcc
//
LOCUS       KCXD01007559             460 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:15064:15102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007559
VERSION     KCXD01007559.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 460)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 460)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:15064:15102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..458
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..458
     V_segment       101..393
                     /gene="IGHV4-149"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <386..>427
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66041.1"
                     /translation="CAREGISASGVDYW"
     D_segment       397..403
                     /gene="IGHD5-32"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..458
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        459..>460
                     /gene="IGHG"
BASE COUNT           81 a          135 c          145 g           99 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggtag ctcccacatg ggtcctgtcc caggtgcaac ttcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggttactggt ggggctggat ccgccagtcc ccagggaagg ggctggagtg
      241 gattgggttt ttcggtggtc gcaatgggaa cacgtactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaccagaca cgtccaaaga gcagttctcc ctgaggctga ggtctgtgac
      361 cgccgcggac acggccgtgt attactgtgc gagggagggg atatcagcgt cgggggtcga
      421 ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007560             336 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:28503:17822
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007560
VERSION     KCXD01007560.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 336)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 336)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:28503:17822"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..334
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..334
     V_segment       7..273
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <265..>303
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66042.1"
                     /translation="CTRGEYSNSIDYW"
     D_segment       277..289
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       293..334
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        335..>336
                     /gene="IGHG"
BASE COUNT           83 a           81 c           90 g           82 t
ORIGIN      
        1 acatggggct tggttcagcc gggggggtcc ctgaggctct cctgtgcagc ctctggattc
       61 accttcagta attatggctt ccactgggtc cgccaggctc cagtgaaggg gctggagtgg
      121 gttgcagtta tatcgtatga tgaaaatgtg aaattctacg cagactctgt aaaggaccga
      181 ttcaccatct ccagagacaa ttccaagaac atgctatatc ttcaaatgaa caacctgaaa
      241 ttggaggaca cggccgtgta ttactgtacg agaggggaat acagtaactc tattgactac
      301 tggggccagg gagtcctggt caccatctcc tcagcc
//
LOCUS       KCXD01007561             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21233:9148
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007561
VERSION     KCXD01007561.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21233:9148"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..499
     V_segment       139..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66043.1"
                     /translation="CARSWGRWSAEYVDFW"
     D_segment       430..435
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..499
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          110 a          116 c          153 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggagtcac catggagtat ttgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagaag gtggagtctg ggggaggcct ggtacagcct
      181 ggggcgtccc tgagactctc ctgtgtagcc tctgaattca ccttcagtag ctatgacatg
      241 cactggattc gccaggctcc agggaagggt ctggagtggg tatcaggtat tagcattggc
      301 ggcaccacat actacccaga ctctgtgaag ggtcgtttca tcatctccag agacaatacc
      361 gagaagtcct tgtatcttca aatgaacagc ctgagaactg aggacactgc tgtatatttt
      421 tgtgcaagat cgtggggcag gtggtcagcg gaatacgtcg acttctgggg ccagggcgcc
      481 ctggtcagcg tctcctcagc c
//
LOCUS       KCXD01007562             307 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:8347:23342
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007562
VERSION     KCXD01007562.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 307)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 307)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:8347:23342"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..305
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..305
     V_segment       8..242
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <236..>274
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66044.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       253..258
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       264..305
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        306..>307
                     /gene="IGHG"
BASE COUNT           72 a           76 c           87 g           72 t
ORIGIN      
        1 acatgggctc tcctgtgcag tctctgggtt caccttcatt ggctctggca tgcactgggt
       61 ccgccaggct ccagggaagg ggctggaatg ggtggcggtt atatcgaatg atggaactaa
      121 caaatactac gcagactctc tgaaggaccg atttagtatc tccagagaga attccaagaa
      181 catgctatat cttcaaatga acaacctgaa actggaggac acggccgtct attactgcgc
      241 gacagatgcg tttggtagcg ggattgacta ctggggccgg ggagtcctgg tcaccgtctc
      301 ctcagcc
//
LOCUS       KCXD01007563             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:18116:18764
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007563
VERSION     KCXD01007563.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:18116:18764"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66045.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          111 a          113 c          153 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggttc atctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcactttc agtacctttg
      241 gcatgcattg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacatcgt
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gagcctgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tatattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007564             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7502:8398
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007564
VERSION     KCXD01007564.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7502:8398"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66046.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       409..417
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          133 c          137 g          105 t
ORIGIN      
        1 acatggggaa tgttctctga gagtcacgga catcctgtgc aagaacatga agcacctgtg
       61 gttcttcctc ctcttggtgg cagctcccag atgggtcctg tcccagctgc ggctgcagga
      121 gtcgggccca ggactggtga agcctccgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctctatc agcagtagtt actgcagctg gatccgccag accccaggga agggactgga
      241 gtggattggg tatatctatg ggagtgatag tagtaccaac tacaacccct ccctcaagag
      301 tcgagtcacc ctgtcagtag acacgtccaa gaaccagtgc tccctgaagc tgagctctgt
      361 gaccgccgcg gacacggccg tgtattattg tgcgagttcg ggtatagaag tggttgccta
      421 cagcattgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007565             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:23994:12324
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007565
VERSION     KCXD01007565.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:23994:12324"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..491
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66047.1"
                     /translation="CARDDSGVIIDYW"
     D_segment       435..443
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>495
                     /gene="IGHG"
BASE COUNT          114 a          109 c          157 g          115 t
ORIGIN      
        1 acatggggtg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcagctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgaagcc tctggattca ccttcagtta ctatggcatg
      241 cactgggtcc gccaggctcc agggaagggg ctggggtggg tggcagttat gtcgaatgat
      301 ggaagtaaga aatactacgg agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca ggctatatct tcaaatgaac aacctgaaat tggaggacac ggcagtgtat
      421 tactgtgcga gagatgatag tggggtgatc atcgactact ggggccaggg agtcctggtc
      481 accgtctcct ccgcc
//
LOCUS       KCXD01007566             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:21629:8586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007566
VERSION     KCXD01007566.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:21629:8586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66048.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          149 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagctatg
      241 gcttacactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 ctgatgaaag taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattattg tgcgagggat gataatgggg tgcttatcga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007567             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:7395:17460
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007567
VERSION     KCXD01007567.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:7395:17460"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    86..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        86..452
     V_segment       86..379
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <371..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66049.1"
                     /translation="CARRGYNNADDWYFDFW"
     D_segment       381..389
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       402..452
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           98 a          132 c          132 g           92 t
ORIGIN      
        1 acatgggctg ggaacacagc tcatcaccat ggactggacc tggaggctcc tctttgtggt
       61 ggcagcagct acaggtgccc agtcccaggt ccaactggtg cagtccgggg ctgaggtgaa
      121 ggagcctggg gcctcagtga agctctcctg ccaggcttct ggatacacct tcggcatcta
      181 cgccatcaat tgggtgcgac aggcccctgg acaagggctt gagtggatgg gagggatcac
      241 ccctcttatt ggcttaacaa actacgcaca gaagttccag ggcagagtca cgctcaccgc
      301 ggacacgtcc acaagtacag tctacatcga gttgaacagc ctgagatctg aggacacggc
      361 cgtgtatttc tgtgcgagac gtggatacaa caacgctgac gactggtact tcgatttctg
      421 gggccctggc accccgatca ccgtctcctc agcc
//
LOCUS       KCXD01007568             327 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:8529:13345
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007568
VERSION     KCXD01007568.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 327)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 327)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:8529:13345"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    7..325
                     /note="immunoglobulin heavy chain variable region"
     V_region        7..325
     V_segment       7..258
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <250..>294
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66050.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       259..263
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       279..325
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        326..>327
                     /gene="IGHG"
BASE COUNT           73 a           85 c          101 g           68 t
ORIGIN      
        1 acatgggggg ggtccctgag actctcctgc gcagcctctg gattcaactt caattactac
       61 tacatgaact gggtccgcca ggctccaggg aaggggctgg agtggatctc aggtattaac
      121 agtggtgggg agagcacata ctatgcggac tccgtgaagg gcagattcac catctccaga
      181 gagaacgcca agaacacact gtatcttcaa atggacagcc tgagagctga ggacacggct
      241 gtctattact gtgcgagagt ggtgggtggt gccgcaggat acttcgactt ctggggccag
      301 ggcgccctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007569             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:7010:9362
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007569
VERSION     KCXD01007569.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:7010:9362"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66051.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       441..446
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          114 a          111 c          152 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacg atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtcggg aggaggcttg gttcagccgg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcactacc tatggcatcc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaacaaagaa atactacgca gactctctga aggaccgctt catcatctcc agagacaatt
      361 ccaagaatat ggtatatctt caaatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgtgag agatgttagg ggaacggggt ttgacttctg gggccagggt gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007570             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19841:18407
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007570
VERSION     KCXD01007570.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19841:18407"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..430
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66052.1"
                     /translation="CVRGMDNYHFSNTDFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       467..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          115 a          123 c          146 g          129 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 tctatattaa aaggtgtcca gtgtgtggag catctggtgg agtctggggg aggcttggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtggctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctag aatgggtatc aggtattaac
      301 attggcggtg acccatacta cccagactct gtgcagggtc gattcaccat ctccagagac
      361 aacgccaaga actccttgta tcttcaaatg aacaacctga gacctgagga cactgctgtg
      421 tattattgtg tgagggggat ggataactac cacttcagta atacggactt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007571             496 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9908:17869
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007571
VERSION     KCXD01007571.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9908:17869"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..494
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..494
     V_segment       125..418
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>463
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66053.1"
                     /translation="CARERCTSSVCAGFLDSW"
     D_segment       419..423
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..494
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        495..>496
                     /gene="IGHG"
BASE COUNT          113 a          147 c          136 g          100 t
ORIGIN      
        1 acatggggga tcacaaaaca accacatccc tcctctaaag aagcccctgg gagcacagct
       61 catcaccatg gactggacct ggaggctcct ctttgtggtg gcagcagctg caggtgtcca
      121 gtcccaggtc cacctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 aatttcctgc ggggcttctg gattcacctt cgacacccat ggtatcaact gggtgcgaca
      241 ggcccctgga caaggacttc agtggatggg agtgatcatc ccccttattg gtatcaccaa
      301 ctacgcaaag aactctcagg gcagagtcac actaaccgcg gacacgtcca caaacacagc
      361 ctacatggag ctgaacagcc tgagatttga ggacacggcc atctactact gtgcgagaga
      421 acgctgcact tctagtgttt gcgccgggtt ccttgactcc tggggccagg gagtcctggt
      481 caccgtctcc tcagcc
//
LOCUS       KCXD01007572             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11412:10797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007572
VERSION     KCXD01007572.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11412:10797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..493
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..493
     V_segment       139..432
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <424..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66054.1"
                     /translation="CARDVFGGGLDYW"
     D_segment       435..439
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..493
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        494..>495
                     /gene="IGHG"
BASE COUNT          109 a          117 c          151 g          118 t
ORIGIN      
        1 acatgggggg ggagaggagc ccagccctgg aagtccacag tgttccattc ggtgatcagc
       61 acagaacaca gaggactcac catgaagttt gggctgagct gggttttcct tgttgctatt
      121 ttaagaggtg tccagtgtga ggtgcatctg gtggagtctg gaggaggctt ggttcagcct
      181 ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtac ctttggcatg
      241 cactgggtcc gccaggctcc aggaaagggg ctggactggg tggcagttat gtcgtctgat
      301 ggaaataaca aatactacgc agactctgtg aaggaccgat tcaccatctc cagagacaat
      361 tccaagaaca tgctctatct tcaaatgaac aacctgaaat tggaggacac ggccgtatat
      421 tactgtgcga gagatgtctt tggcgggggg cttgactact ggggccaggg agtcctggtc
      481 accgtctcct cagcc
//
LOCUS       KCXD01007573             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:13786:11299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007573
VERSION     KCXD01007573.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:13786:11299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..496
     V_segment       142..435
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66055.1"
                     /translation="CGRDDNGVIIDYW"
     D_segment       444..456
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          114 a          110 c          154 g          120 t
ORIGIN      
        1 acatggggct ctgggagagg agcccagccc tggaagtcca cagtgttcca ttcggtgatc
       61 agcacagaac acagaggact caccatgaag tttgggctga gctgggtttt ccttgttgct
      121 attttaagag gtgtccagtg tgaggtgcag ctggtggagt ctggaggagg cttggttcag
      181 ccgggggggt ccctgagact ctcctgtgca gcttcggggt tcatcttcag tagttatggc
      241 atgcactggg tccgcctggc tccagggaag gggctggagt gggtggcagt aacatcgtct
      301 gatgaaagta agaaattcta cggagactct gtgaaggacc gattcaccat ctccagagac
      361 aattcccaga acatactata tcttcaaatg aacaacctga aattgaagga cacggccgtc
      421 tactattgtg ggagagatga taatggggtg attattgact actggggcca gggagtcctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007574             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:20574:12127
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007574
VERSION     KCXD01007574.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:20574:12127"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66056.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          137 c          128 g          110 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcatctgca ctgtctctgg
      181 tgattccatc agcaatagct actggaactg gatccgccag ccccctggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccacttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtactactg cgtgagatat gaggatgagt ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtctccgtc tcctcagcc
//
LOCUS       KCXD01007575             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:21176:15304
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007575
VERSION     KCXD01007575.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:21176:15304"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66057.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          108 a          112 c          156 g          123 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctgggggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcatgttca gtaactttgg
      241 catccactgg gtccgccagg ctccagggaa ggggctggag tgggtgtcag ttatatcgta
      301 tgatgtaact gtgaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacacgctat atcttcaaat gcacaacctg aaattggagg acacggccgt
      421 gtattattgt gtgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcgtcagcc
//
LOCUS       KCXD01007576             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:23192:7426
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007576
VERSION     KCXD01007576.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:23192:7426"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..480
     V_segment       115..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66058.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       419..425
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          113 a          132 c          136 g          101 t
ORIGIN      
        1 acatggggaa ccacgtccct cctctaaaga agcccctggg aacacagctc atcaccatgg
       61 acttgacctg gaggctcctc tttgtggtgg cagcagctac aggtgcccag tctcaggtcc
      121 agctggtgca gtccggggct gagatggaga agcctggggc ctcagtgaag ctctcctgta
      181 aggcttctgg atacaccttc agcatctatg tcatcagttg ggtgcgacag gcccctggaa
      241 aagggcttga gtggatggga agtgttgatc ctcaatatgg tgaaatgata gacgcagaga
      301 aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc tacatggagc
      361 tgagcagtct gagatctgag gacacggccg tgtattactg tgcgacatca tccagcggca
      421 cctggctata ctggtacttc gatatctggg gccctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01007577             487 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:25494:7970
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007577
VERSION     KCXD01007577.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 487)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 487)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:25494:7970"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..485
     V_segment       119..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <404..>454
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66059.1"
                     /translation="CARSGSGTWNGWYLDLW"
     D_segment       418..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>487
                     /gene="IGHG"
BASE COUNT          115 a          137 c          139 g           96 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccagtctga
      121 ggtccagctg gtgcagtctg gggctgaggt gaagaagcct gggacctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccttcaccga attatccatt cattgggtgc gacaggcccc
      241 tggaaaaggg cttgagtggg tgggaactat tgatcctctt tatggtgaaa tgatacacac
      301 agagaagttc cagggcagag tcaccatgac cgaggacacg tctacagata cagcctacat
      361 ggagctgagg agcctgagat ctgaggacac ggccgtatat tattgtgcga ggtcgggtag
      421 cggcacttgg aacggctggt acctcgatct ctggggccct ggcaccccaa tcaccgtctc
      481 ctcagcc
//
LOCUS       KCXD01007578             452 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:16168:21103
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007578
VERSION     KCXD01007578.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:16168:21103"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..450
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..450
     V_segment       87..379
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <372..>419
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66060.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       392..400
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..450
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        451..>452
                     /gene="IGHG"
BASE COUNT           90 a          131 c          133 g           98 t
ORIGIN      
        1 acatggggac ggacatcctg tgcaagaaca tgaagcacct gtggttcttc ctcctcctgg
       61 tggcagctcc cagatgggtc ctgtcccagc tgcggctgca ggagtcgggc ccaggactgg
      121 tgaagcctcc ggagaccctg tccctcacct gcgctgtctc tggtggctct atcagcagta
      181 gttactgcag ctggatccgc cagaccccag ggaagggact ggagtggatt gggtatatct
      241 atgggagtga tagtagtacc aactacaacc cctccctcaa gagtcgagtc accctgtcag
      301 tagacacgtc caagaaccag tgctccctga agctgagctc tgtgaccgcc gcggacacgg
      361 ccgtgtatta ttgtgcgagt tcgggtatag aagtggttgc ctacagcatt gactactggg
      421 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007579             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19462:8210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007579
VERSION     KCXD01007579.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19462:8210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..429
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66061.1"
                     /translation="CATDAFGSGIDYW"
     D_segment       440..445
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          115 c          153 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgaa gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtgac tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcggttata tccaatgatg
      301 gaagtaagaa atactacgca gactctgtga aggaccgatt cagcatttcc agggacaacc
      361 ccaagaacat gctatatctt caaatgaaca acctgaaatt ggatgacacg gccgtctatt
      421 actgtgcgac agatgcgttt ggtagcggga ttgactactg gggccgggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007580             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14354:2375
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007580
VERSION     KCXD01007580.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14354:2375"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66062.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          115 c          151 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atatttagag
      361 acaattccaa gagcatcctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattactg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007581             507 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:25866:12397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007581
VERSION     KCXD01007581.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 507)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 507)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:25866:12397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..505
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..505
     V_segment       145..433
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <427..>474
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66063.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       442..453
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..505
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        506..>507
                     /gene="IGHG"
BASE COUNT          107 a          125 c          159 g          116 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag cactggaagt ccacagtgtt ccattcggtg
       61 atcagcactg aacacagagg actcaccatg gagtctgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg caactggtgg agtctggggg cggcttggcg
      181 aagcctgggg gatccctgag actcttctgt gcagcctctg gatttacctt caatacctat
      241 tctatacact gggtccgcca ggctcccggg aaggggctgg agtgggtctc agccattagt
      301 agtggtggta gaacatacta cgcagactcc gtgaagggcc gagtcaccat ctccagagac
      361 aactcaaaga acacagtctc cctgcaaatg aacagcctgg gagctgagga cacggccgtg
      421 ttttactgtg cgagagggga gacagcttca gtttactacg gtttggattc ctggggccaa
      481 ggggtcgtcg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007582             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:21290:5324
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007582
VERSION     KCXD01007582.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:21290:5324"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..400
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66064.1"
                     /translation="CSRVRGYNYILFDSW"
     D_segment       406..420
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          137 c          129 g          110 t
ORIGIN      
        1 acatgggggg atgttctctg agagtcacgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacatgc gctgtctctg
      181 gtgactctat cagcagtagt cactggtgga gctggatccg ccagccccca gggaaaggcc
      241 tggagtggat tggctatatc agtggtagtg gtgataacac ctactacaac ccctccctca
      301 agaatcgagt caccttttca acagtcacgt ccaagaacca gttctccctt aagctgagct
      361 ctgtgaccgc cgcggacacg gccatgtatt actgttcgag ggtgcgtgga tacaactaca
      421 ttttatttga ctcctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007583             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19955:17207
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007583
VERSION     KCXD01007583.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19955:17207"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..496
     V_segment       117..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66065.1"
                     /translation="CAKSVNYEEDNGYYIPTQFDYW"
     D_segment       418..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..496
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>500
                     /gene="IGHG"
BASE COUNT          115 a          141 c          142 g          102 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgaggtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggattcacc ttcagcaccg atgccatcag ttgggtgcga caggcccctg
      241 gacaagggct tgactggatg ggaggggtca tccctcttat gggtacaaca aactacgcac
      301 agaagttcca gggcagagtc acgtttaccg cggacacgtc cctaaccaca gcctacatgg
      361 aactgagcag cctgagatct gaggacacgg ccgtgtatta ttgtgcgaaa tccgtgaatt
      421 acgaggaaga taacggttac tatataccga cgcagtttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctctgcc
//
LOCUS       KCXD01007584             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:25343:11619
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007584
VERSION     KCXD01007584.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:25343:11619"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66066.1"
                     /translation="CVTVGPYHYFDFW"
     D_segment       420..425
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          117 a          143 c          130 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgaggt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttcc ggatacacct taaccgacca ctacctacac tgggtgcgac
      241 agactcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagtag
      301 actacacaca gaagttccaa gacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 tctacatgga gctgaggagc ctgagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgggtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01007585             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:10149:18300
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007585
VERSION     KCXD01007585.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:10149:18300"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66067.1"
                     /translation="CVRDVRGTGFDYW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          115 a          113 c          153 g          118 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc aatcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatccta
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcccca tctccagaga
      361 caattccaaa aacatgatat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattattgt gtgagagatg tcaggggaac ggggtttgac tactggggcc ggggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007586             439 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:21907:11658
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007586
VERSION     KCXD01007586.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 439)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 439)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:21907:11658"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..437
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..437
     V_segment       74..366
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>406
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66068.1"
                     /translation="CASSGIEVVAYSIDYW"
     D_segment       379..387
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       396..437
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        438..>439
                     /gene="IGHG"
BASE COUNT           87 a          126 c          130 g           96 t
ORIGIN      
        1 acatgggggc aagaacatga agcacctgtg gttcttcctc ctcctggtgg cagctcccag
       61 atgggtcctg tcccagctgc agctgcagga gtcgggccca ggactggtga agcctccgga
      121 gaccctgtcc ctcacctgcg ctgtctctgg tggctctatc agcagtagtt actgcagctg
      181 gatccgccag accccaggga agggactgga gtggattggg tatatatttg ggagtgatag
      241 tagtaccaac tacaacccct ccctcaagag tcgagtcacc ctgtcagtag acacgtccaa
      301 gaaccagtgc tccctgaggc tgagctctgt gaccgccgcg gacacggccg tgtattattg
      361 tgcgagttcg ggtatagaag tggttgccta cagcattgac tactggggcc agggagtcct
      421 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007587             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:19735:13944
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007587
VERSION     KCXD01007587.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:19735:13944"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..491
     V_segment       137..430
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66069.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       436..441
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          108 a          111 c          155 g          119 t
ORIGIN      
        1 acatgggggg agaggagccc agccctggaa gtccacagtg ttccattcgg tgatcagcac
       61 agaacacaga ggactcacca tgaagtttgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggcggcttgg ttcagcctgg
      181 ggggtccctg agactctcct gtgtagcctc tggattcacc ttcagtagta gtggcatgca
      241 ttgggtccgc caggctccag ggaaggggct ggagtggctg gctgttgaat cccatgatgg
      301 aaataagaaa tactatgcag actccgtgaa ggaccgattc accatctcca gagacaattc
      361 caagaacatg gtatatcttc aaatgagcaa cctgaaattg gtggatacgg ccatgtatta
      421 ctgtgtgaga gatgcctacg ggggcggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007588             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:8373:20750
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007588
VERSION     KCXD01007588.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:8373:20750"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    108..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        108..459
     V_segment       108..397
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66070.1"
                     /translation="CASNSITSGPDYW"
     D_segment       403..409
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           93 a          140 c          124 g          104 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caagaacatg aggcacctgt
       61 ggttcttcct cctcctggcg gcagctccca gatgggtcct gtcccgcctg cagctgcagg
      121 cgtcgggccc aggactggtg aagccttcgg agaccctgtc tctcacctgc gctgtctctg
      181 gtgcctctat cagcggtaac tactggagct ggatccgcca ggccccaggg aagggactgg
      241 agtggattgg atatatctat ggtagtgata ttagtaccaa ctacaacccc tccctcaaga
      301 gtcgagtcac cctgtcagta gacacgtcca agaaccagtt ctccctgaac ctggcctctg
      361 tgaccgccgc ggacacggcc atctatttct gtgccagtaa cagtataaca tctggtccag
      421 actattgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007589             454 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:10962:9623
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007589
VERSION     KCXD01007589.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 454)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 454)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:10962:9623"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..452
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..452
     V_segment       101..397
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>421
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66071.1"
                     /translation="CARWGTPFDYW"
     D_segment       398..402
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..452
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        453..>454
                     /gene="IGHG"
BASE COUNT           86 a          134 c          133 g          101 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacct cctgggcaag aacatgaagc atctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcttgtcc caggtgcagc tgcaggagtc
      121 gggcccagga ctggtgaagt cttcggagac cctgtccctc acctgcgctg tctctggtag
      181 ctccatcaac agtggttatg cctggggctg gatccgccag cccccaggga aggggctgga
      241 gtgggttggt catacctatg atagtagtgg gaacacctac tacaacccct ccctcaagag
      301 tcgagtcacc atttctaaag acacgtccaa gaaccagttc tccctgaggc tgaattctgt
      361 gaccgccgcg gacacggccg tgtattactg tgcgagatgg gggaccccct ttgactactg
      421 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007590             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:18325:9761
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007590
VERSION     KCXD01007590.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:18325:9761"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66072.1"
                     /translation="CARYSDTDSYYYFDYW"
     D_segment       411..423
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           94 a          138 c          127 g          109 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca gcaatagcta ctggatctgg atccgccagc ccccagggaa ggggctggag
      241 tggatagggt ctatctatgg tggtactggg agcacctttt acgacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaac aaccaatttt ccctgaagct ggactctgtg
      361 accgccgcgg acaccgccgt ctattactgt gcgagatata gcgatactga tagttattac
      421 tactttgact actggggcca gggagtccgg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007591             473 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:9674:12242
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007591
VERSION     KCXD01007591.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:9674:12242"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    99..471
                     /note="immunoglobulin heavy chain variable region"
     V_region        99..471
     V_segment       99..395
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <387..>440
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66073.1"
                     /translation="CARGSYSGSYYFNRFDVW"
     D_segment       401..420
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..471
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        472..>473
                     /gene="IGHG"
BASE COUNT           91 a          138 c          136 g          108 t
ORIGIN      
        1 acatggggtc tctgagagtc acggacctcc tgtgcaagaa catgaagcac ctgtggttct
       61 tcctcctcct ggtggcagct cccagatggg tcctgtccca ggtgcagctg caggagtcgg
      121 gcccaggact ggtgaagcct tcggagaccc tgtccctcac atgcgctgtc tctggtggct
      181 ccatcagcag tagtacctgg tggaactggg tccgccagcc cccagggaaa ggcctggagt
      241 ggataggata tatcaatggt gagagtggta gcacctacta caatccctcc ctcgagagtc
      301 gaatcaccat ttcaacagac acgtccacga accagttttc cctgaggctg agctctgtga
      361 ccgccgcgga cacggccgtg tatttctgtg cgagaggttc ctatagtggt agttattact
      421 tcaaccggtt cgatgtctgg ggcccgggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007592             375 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:6195:11797
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007592
VERSION     KCXD01007592.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 375)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 375)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:6195:11797"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    3..373
                     /note="immunoglobulin heavy chain variable region"
     V_region        3..373
     V_segment       3..293
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <292..>342
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66074.1"
                     /translation="CTTLYGGSYYVDYFDSW"
     D_segment       308..321
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       326..373
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        374..>375
                     /gene="IGHG"
BASE COUNT           82 a           96 c          109 g           88 t
ORIGIN      
        1 atggggcagc tggtggagtc tgggggcggc ttggtccagc ctggcgggtc cctgagactc
       61 tcctgtgcag cctctggatt caccttcgat gaatatggct tgagctgggt ccgccaggct
      121 tctgggaaag gactggagtg ggttggctat attagaagcc aatacaggaa ttacgcgaca
      181 gaatacgccg catcggtgaa aggcagattc tccatctcca gagatgattc aaagaacacg
      241 ctttatctac aaatgagcag cctgacaacc gaggacacgg ccgtctatta ttgcaccacc
      301 ctctatggtg gtagttatta cgtggactac tttgactcct ggggccaggg agtcctggtc
      361 accgtctcct cagcc
//
LOCUS       KCXD01007593             450 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:11659:10590
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007593
VERSION     KCXD01007593.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 450)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:11659:10590"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..446
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..446
     V_segment       137..369
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <361..>417
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66075.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       392..399
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       401..446
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        447..>450
                     /gene="IGHG"
BASE COUNT           97 a          117 c          130 g          106 t
ORIGIN      
        1 acatggggag ctctgagaca ggagccttag ccctggattc caagaacttc cactttggga
       61 tcagctctga acacagagga ccatggagtt ggggctgagc tgggttttcc ttgttgctat
      121 tttaaaaggt gtccagcctg tgcagcctct ggattcacct ttggtgatta tggcatgcac
      181 tgggtccgcc aggctccggg aaagggactg gagtgggtct catccattag gaacactggt
      241 aaaatcgtat actacgctga ctccgtgaag ggccgattca ccatttccag agacaacgcc
      301 aagaactcgc tgtctctgcg aatgagcagc ctgagagccg aggacacggc cgtgtactac
      361 tgtactagaa ttggcgtcgg atctctggca acggctggtg actactttga ccactggggc
      421 cagggagtcc tggtcaccgt ctcctccgcc
//
LOCUS       KCXD01007594             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:27162:13348
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007594
VERSION     KCXD01007594.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:27162:13348"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..495
     V_segment       138..431
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66076.1"
                     /translation="CVQGEIFGVGLDSW"
     D_segment       441..446
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..495
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          115 c          158 g          115 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagg cactggatga
      241 actgggtccg tcaggctcca ggaaaggggc tagagtgggt ctcaactatt aatagtggtg
      301 gggataacac atattacgca aactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctcctcctg caaatgaaca gcctgagagt ggaggacacg gccgtgtatt
      421 attgtgttca aggggaaatt tttggagtgg gtttggattc ctggggccaa ggggtcgtcg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007595             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:10622:10102
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007595
VERSION     KCXD01007595.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:10622:10102"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..464
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66077.1"
                     /translation="CARDEDAYAYYYYFDHW"
     D_segment       397..422
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>470
                     /gene="IGHG"
BASE COUNT           91 a          137 c          141 g          101 t
ORIGIN      
        1 acatggggag ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag cagtaactac tggagctgga tccgccagcc cccagggaag gggctggagt
      241 ggattggacg tatccatggt agtgggggga gcaccgacta caacccctcc ctcaagagtc
      301 gagtcacctt ttcaagagac aggtccaaga accagttctc cctggagctg agctctgtga
      361 ccgcggcgga ctcggccgtg tattattgtg cgagagacga ggatgcttac gcttactatt
      421 actactttga ccactggggc cagggagtcc tggtcaccgt ctccccagcc
//
LOCUS       KCXD01007596             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:7821:4835
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007596
VERSION     KCXD01007596.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:7821:4835"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66078.1"
                     /translation="CAREYCTTDDCAGFFDYW"
     D_segment       408..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          111 a          130 c          140 g          104 t
ORIGIN      
        1 acatggggaa ccgcatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctac aggtgtccag tcccaggtcc
      121 agttgatcca gtccggggct gaggtcaaga agcctggggc cgcagtgaag gtttcctgta
      181 aggcctctgg attcaccctc gacaactatg gtatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccaagttgg tataataaat tacggtgaga
      301 gattccagga cagagtcacg attagcgcgg acacgtccat gaatatggcc tacatggagg
      361 tgaccagcct gaaatccgac gacacggcca tctatttctg tgcgagagaa tactgcacca
      421 ctgatgattg cgccggattc tttgactact ggggccaggg agtcctggtc accgtctctt
      481 cagcc
//
LOCUS       KCXD01007597             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:24579:8516
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007597
VERSION     KCXD01007597.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:24579:8516"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66079.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       438..444
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          119 a          141 c          144 g          100 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc aactggtgca gtctggggct gaaatgaaga agcctggggc ctcagttagg
      181 gtctcctgca aggtttccgg aaacaccttc accgaattat ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga tgtgtcgatc ctgcacaagg tgaaataata
      301 tacgcagaga aattccaggg cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 ttcatggagt tgagcagcct gagatctgag gacacggccg tgtatttctg tgcgaaaggg
      421 gggttcggaa ccagcgtctg gtccaacctc ttctacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca ccgtctcttc agcc
//
LOCUS       KCXD01007598             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:16763:7925
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007598
VERSION     KCXD01007598.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:16763:7925"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66080.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          138 c          130 g          108 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggcg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccgt caccagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcagga
      301 gtcgagtcac catttcaaca gacacgtcca agaaccagtt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtattatt gtgtgagata tgaggatgaa tccattaact
      421 accactttga cttctggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007599             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:15791:18898
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007599
VERSION     KCXD01007599.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:15791:18898"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..457
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66081.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       391..398
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       413..457
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           93 a          135 c          126 g          105 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg tgactccatc
      181 accagtagct actggaattg ggtccgccag cccccaggga agggactgga gtggattggg
      241 tatatctctg gtgcttatga gagcaccagc tacaacccct ccctcacggg tcgagtcacc
      301 atttcaactg acacgtccaa gaaccagttt tccctgaggc tgagttctat gaccgccgcg
      361 gacaccgccg tatattactg tgtgagatat gaggatgaat ccattaacta ccactttgac
      421 tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007600             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:8509:7467
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007600
VERSION     KCXD01007600.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:8509:7467"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    129..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        129..501
     V_segment       129..422
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <414..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66082.1"
                     /translation="CTRIGVGSLAPAGEYFDYW"
     D_segment       439..452
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..501
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          104 a          119 c          154 g          126 t
ORIGIN      
        1 acatggggag gagtcttagg cctggattcc aagaacttcc actttgggat cagctctgaa
       61 cacagaggac catggagttg gggctgagct gggttttcct tgttgctatt ttaaaaggtg
      121 tccagtgtga ggtggagctg gtggagtctg ggggaggctt ggtccagcct ggggggtccc
      181 tgagactctc ctgtgtagcc tctggattca cctttggtga ttatggcatg cactgggtcc
      241 gccaggctcc gggaaaggga ctggagtggg tctcatccat tagaaacact ggtaaaatcg
      301 tatactacgc tgactccgtg aagggccgat tcatcatctc cagagacaac gccaagaatt
      361 cgctgtctct gcaaatgagc agcctgagag tcgaggactc ggccgtctat tactgtacta
      421 gaattggcgt cggatctcta gcaccggctg gtgaatactt tgactactgg ggccagggag
      481 tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007601             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:18244:15568
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007601
VERSION     KCXD01007601.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:18244:15568"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..419
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <411..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66083.1"
                     /translation="CVTVCPYHYFDFW"
     D_segment       428..434
                     /gene="IGHD4-21"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          116 a          147 c          127 g           92 t
ORIGIN      
        1 acatggggga gcatcacaca accaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggctcc tcctcttggt ggcagcagct acaggcgccc
      121 actccgacgt ccagctggta cagtctgggg ctgaggtgaa gaagcctggg gcctccgtga
      181 aaatctcctg ccaggcttct ggatacacct taaccgacca ctacctgcac tgggtgcgac
      241 aggctcctgg aaaaggactt gagtggatgg gaggtgttca tcctgaatat ggtaaagcag
      301 actacacaca gaagttccaa aacagagtca ccatcaccgc ggacatgtcg acagagacag
      361 cctacatgga gctgagcagc ctcagatctg aggacacggc cgtttattac tgtgtgacag
      421 tgtgtcccta ccattacttt gacttctggg gccagggagc cctggtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01007602             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:21602:19769
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007602
VERSION     KCXD01007602.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:21602:19769"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66084.1"
                     /translation="CAIGPSGRWNDWSFDIW"
     D_segment       420..428
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          110 a          142 c          134 g           93 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcaactaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattgtc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgcatatggt gaaatgacgt
      301 tccagggcag agtcaccatg accgaggaca cgtctacaga cacagcctac atggaactga
      361 gcagcctgac atctgaggac acggccgtgt attattgcgc gattggccct agtggcagat
      421 ggaacgactg gtccttcgac atctggggac ctggcacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007603             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11631:4854
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007603
VERSION     KCXD01007603.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11631:4854"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    117..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        117..480
     V_segment       117..410
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <402..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66085.1"
                     /translation="CARGLGSSAHFGLDSW"
     D_segment       419..426
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       435..480
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          101 a          139 c          144 g           98 t
ORIGIN      
        1 acatggggaa caaccacgtc cctcctctaa agaagcccct gggaacacag ctcatcacca
       61 tggacttgac ctggaggctc ctctttgtgg tggcagcagc tacaggtgcc cagtcccagg
      121 tccagctggt gcagtccggg gctgatgtga agaagcctgg ggcctcagtg aagctctcct
      181 gcaaggcttc tggattcgcc ttcagaatgt atgccctcag ttgggtgcga caggcccctg
      241 gacaagggct tgagtggctg ggagggatcg tccctcttgt tggaacaaca aactccgcac
      301 agaagttcca ggacagagtc acgattaccg cggacacgtc cacaagcaca gtctacatgg
      361 agctgagcag cctgagatct gacgacacgg ccgtgtatta ctgtgcgaga ggcctgggta
      421 gcagcgccca ctttggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag
      481 cc
//
LOCUS       KCXD01007604             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:9058:10693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007604
VERSION     KCXD01007604.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:9058:10693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..495
     V_segment       126..419
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66086.1"
                     /translation="CARGYCHGSYCSSGLVSW"
     D_segment       420..428
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       461..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          113 a          140 c          146 g           98 t
ORIGIN      
        1 acatggggga gcatcacaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccagttggtg cagtctgggg ctgaagtgag gaagcctggg gtctcagtaa
      181 aggtctcctg caaggtttcc ggaaacacca tcaccgaatt atccgtgcac tgggtgcgac
      241 aggcccctgg aaaaggcctt gagtggatgg ggggtgttga tcccgtctat ggtgaaataa
      301 gacacgcaga gaacttccag ggcagagtca ccatgaccga ggacacgtcg acagacacag
      361 cctacatgga gctgagcagc ctgagatctg aggacacggc cgtctattac tgtgcgcgag
      421 gatattgtca tggtagttac tgttcctcgg gtcttgtctc ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007605             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:19447:20768
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007605
VERSION     KCXD01007605.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:19447:20768"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..485
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..485
     V_segment       120..412
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66087.1"
                     /translation="CASGPSGTWIDWSFDVW"
     D_segment       419..432
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       436..485
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        486..>488
                     /gene="IGHG"
BASE COUNT          118 a          143 c          132 g           95 t
ORIGIN      
        1 acatgggaca cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agctacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggattc accttcaccg atttatccat acactggata cgacaggccc
      241 ctggaaaagg gcttcagtgg atgggaagtg ttgatcctgc atatggtgaa atgataaacg
      301 cagagaagtt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagccttca
      361 tggaattgag cagcctgaaa tctgacgaca cggccgtata ttactgtgcg agtggcccta
      421 gcggcacctg gatcgactgg tccttcgatg tctgggggcc tggcacccca atcaccgtct
      481 cctcaacc
//
LOCUS       KCXD01007606             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:10785:18210
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007606
VERSION     KCXD01007606.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:10785:18210"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <418..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66088.1"
                     /translation="CAKGDTATVYYGLDSW"
     D_segment       429..444
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..496
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          103 a          124 c          156 g          115 t
ORIGIN      
        1 acatggggga gaggagccca gcactggaag tccacagtgt tccattcggt gatcagcact
       61 gaacacagag gactcaccat ggagtctggg ctgagctggg ttttccttgt tgctatttta
      121 agaggtgtcc agtgtgaggt gcaggtggtg gagtctgggg gcggcttggc aaagcctggg
      181 ggatccctga gactctcctg tgcagcctct ggattcacct tcagtaccta tgctatgcac
      241 tgggtccgcc aggctccagg gaaggggctg gagtgggtct cagccattag tgttggtggt
      301 agtacatact acgcagactc cgtgaggggc cgattcacca tctccagaga caactcagag
      361 agcacgctct ccctgcaaat gaacagcctg agtactgagg acacggccgt gtattactgt
      421 gccaaagggg atacagctac agtttattac ggtttggatt cctggggcca aggggtcgtc
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007607             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18810:8090
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007607
VERSION     KCXD01007607.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18810:8090"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..466
     V_segment       103..396
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66089.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       400..407
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..466
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT           95 a          139 c          127 g          107 t
ORIGIN      
        1 acatggggat gctctctgag agtcatggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttccttc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gacaggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 gactccatca ccagtagcta ctggaactgg atccgccagc ccccagggaa gggactggag
      241 tggattgggt atatctctgg tgcttatggg agcaccagct acaacccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aaccagtttt ccctgaggct gagttctgtg
      361 accgccgcgg acaccgccgt ttattactgt gtgagatatg aggatgaatc cattaactac
      421 cactttgact tctggggcca gggagtcctg gtcaccgcct cctcagcc
//
LOCUS       KCXD01007608             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:4348:9327
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007608
VERSION     KCXD01007608.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:4348:9327"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..434
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66090.1"
                     /translation="CARGIDNYHFSNTEFDYW"
     D_segment       446..453
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          118 a          113 c          150 g          132 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagttggtgg aatctggggg aggattggta
      181 cagcctgggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagttat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtgggtatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc gattcactat ctccagagac
      361 aatgccaaga actccgtgta tcttcaaatg aacagcctga gagttgagga cactgctgtg
      421 tatttttgtg caagggggat agataactac cactttagta atacggagtt tgactactgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007609             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:3052:15569
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007609
VERSION     KCXD01007609.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:3052:15569"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66091.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       428..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          122 a          141 c          133 g           95 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa cgtttccgga tacatcttaa ccgaattatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggaa gtgttgatcc tcaatatggt gaaatgatag
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagtctg agatctgagg acacggccgt gtattactgt gcgacatcat
      421 ccagcggcac ctggctatac tggtacttcg atatctgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01007610             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:9851:15875
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007610
VERSION     KCXD01007610.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:9851:15875"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66092.1"
                     /translation="CAKGGFGTSVWSNLFYGLDSW"
     D_segment       437..443
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          119 a          140 c          144 g          100 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca actggtgcag tctggggctg aaatgaagaa gcctggggcc tcagttaggg
      181 tctcctgcaa ggtttccgga aacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgtcgatcc tgcacaaggt gaaataatat
      301 acgcagagaa attccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 tcatggagtt gagcagcctg agatctgagg acacggccgt gtatttctgt gcgaaagggg
      421 ggttcggaac cagcgtctgg tccaacctct tctacggttt ggattcctgg ggccaagggg
      481 tcgtcgtcac cgtctcttca gcc
//
LOCUS       KCXD01007611             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18767:18740
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007611
VERSION     KCXD01007611.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18767:18740"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    140..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        140..500
     V_segment       140..433
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <425..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66093.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       435..441
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT           99 a          124 c          160 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagcccc agaattccca ggtgtttctg ttcggcgatc
       61 agcactaaac acagaacata ccatggagtt tgtgctgagc tgggttttcc ttgttgctct
      121 tttgaaaggt gtccagtgtg aggtgcagct ggtggagtct gggggcggct tggcaaagcc
      181 tggggggtcc ctgagactct cctgcgcagc ctctggtttc agcttcagtt tctactatat
      241 gacctgggtc cgccaggctc cagggaaggg gctggagtgg atctcaggta ttgacactgg
      301 tggggatagc acctactatg cagactccgt gaagggcaga ttcaccatct ccagagagaa
      361 cgccaagaag acactgtatc ttcagatgga cagcctgaga gctgaggaca cggctgtcta
      421 ttactgtgcg agagtagtgg gtggtgccgc cggatacttc gatttctggg gccagggcgc
      481 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007612             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13000:17041
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007612
VERSION     KCXD01007612.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13000:17041"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66094.1"
                     /translation="CARDVRGTGFDFW"
     D_segment       446..451
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..497
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          117 a          114 c          151 g          117 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggaa acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatccta
      301 tgatgaaact aagaaatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaaa aacatggtat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 atattactgt gcgagagatg tcaggggaac ggggtttgac ttctggggcc agggagtcct
      481 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007613             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1115:21227:14556
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007613
VERSION     KCXD01007613.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1115:21227:14556"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66095.1"
                     /translation="CARGEYSNSIDYW"
     D_segment       435..447
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          112 a          111 c          155 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagtct ctggattcac cttcagtagc tttggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagtgaca tcgtatgatg
      301 gaagttggaa gtactacgga gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat gctatatctt cagatgaaca acctgaaatt ggaggacacg gccgtatatt
      421 actgtgcgag aggggaatac agtaactcta ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007614             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:18459:10152
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007614
VERSION     KCXD01007614.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:18459:10152"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..327
     V_segment       8..251
                     /gene="IGHV4-67"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <243..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66096.1"
                     /translation="CTREWGAIAAVGPVLASW"
     D_segment       263..273
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       293..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           67 a           94 c           96 g           72 t
ORIGIN      
        1 acatggggtc cctcacctgc gctgtctctg gtgactccat caccagtagt aattggtgga
       61 gctggatccg ccagtcccca gggaagggac tggaatggat tgggggtatc tatggtagtg
      121 gtgggaatac cgaatacaac ccctccctca agagtcgagt caccatttca aaggacacgt
      181 ccaagaacca gttctccctg aagctgaact ctgtgaccgc cgcggacacc gccgtgtatt
      241 actgtacgag agaatggggc gctatagcgg cagttgggcc tgtccttgcc tcctggggcc
      301 agggtgtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007615             516 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:16350:12031
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007615
VERSION     KCXD01007615.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 516)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 516)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:16350:12031"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    142..514
                     /note="immunoglobulin heavy chain variable region"
     V_region        142..514
     V_segment       142..434
                     /gene="IGHV3-37"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <433..>483
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66097.1"
                     /translation="CTRLYSGNYRIMMFDYW"
     D_segment       445..454
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       472..514
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        515..>516
                     /gene="IGHG"
BASE COUNT          124 a          115 c          150 g          127 t
ORIGIN      
        1 acatggggct gggagaggag acccagcctt gggatttcca gctgtctcca cttggtgatc
       61 agcactgaac acaggagact cgccatggag tttgtactga gctgggtttt ccttgttgct
      121 atattaaaag gtgtccagtg tgaggtgcag ctggtggaat ctgggggagg cttggtccag
      181 cctggcgggt ccctgagact ctcctgtgca gcctctggat tcaccttcaa tgagtatgcc
      241 atgagctggg tccgccaggc ttctgggaaa ggactggagt ggattggtta tattagaagc
      301 aaatataaca attacgcgac agaatatgcc gcatcggtga aaggcagatt caccatctcc
      361 agagatgatt caaagaacac actatatctg cagatgagca gcctgaaaac cgaggagacg
      421 gccgtgtatt actgcacccg tctctatagt gggaactata gaattatgat gtttgactac
      481 tggggccagg gagtcctggt cagtgtctcc tcagcc
//
LOCUS       KCXD01007616             376 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6607:7065
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007616
VERSION     KCXD01007616.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 376)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 376)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6607:7065"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    20..374
                     /note="immunoglobulin heavy chain variable region"
     V_region        20..374
     V_segment       20..313
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <305..>343
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66098.1"
                     /translation="CARGDYGNSLDFW"
     D_segment       317..328
                     /gene="IGHD4-25"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       333..374
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        375..>376
                     /gene="IGHG"
BASE COUNT           82 a           90 c          117 g           87 t
ORIGIN      
        1 acatgggggt gtccattgtg aggtgcagct ggtggagtct ggaggaggct tggttcagcc
       61 gggggggtcc ctgagactct cctgtgcagc ctctggattc accttcagta actatggcat
      121 gcactgggtc cgccaggctc cagggaaggg tctggagtgg gtggcagtta tgtcgcatga
      181 tggaactaag aaattctacg cagactctgt gaaggaccga ttcaccatct ccagggacaa
      241 ttccaagaac atggtatatc ttcaaatgaa caacctgaga ttggaggacg cggccgtcta
      301 ttattgtgcg agaggagact acggtaacag ccttgacttc tggggccagg gagtcctgct
      361 caccgtctcc tcagcc
//
LOCUS       KCXD01007617             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:20870:17937
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007617
VERSION     KCXD01007617.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:20870:17937"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..497
     V_segment       137..426
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <419..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66099.1"
                     /translation="CVKGDTAAVYYGLDFW"
     D_segment       430..439
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          102 a          127 c          154 g          116 t
ORIGIN      
        1 acatgggggg agaggagccc agcactggca gtccacagtg ttccattcgg tgatcagcac
       61 tgaacacaga ggactcacca tggagtctgg gctgagctgg gttttccttg ttgctatttt
      121 aagaggtgtc cagtgtgagg tgcagctggt ggagtctggg ggcggcttgg cagagcctgg
      181 gggatccctg agactctcct gtgcagcctc tggattcacc ttcagtacct atgctgttca
      241 ctgggtccgc caggctccag aaaaggggct ggagtgggtc tcagctgtta gtaccggtgg
      301 taccacatac tactcagact ccgtgaaggg ccgattcacc atctccagag acaactcaaa
      361 gaacacgttc tcccttcaaa tgagcagcct gagagctgag gacacggccg tgtattactg
      421 tgtgaagggg gatacagctg cagtctacta cggtttggat ttctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007618             505 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:26230:7112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007618
VERSION     KCXD01007618.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 505)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 505)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:26230:7112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..503
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..503
     V_segment       125..418
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <410..>472
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66100.1"
                     /translation="CARGRFGSSVWSNLVYGFDSW"
     D_segment       429..435
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..503
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        504..>505
                     /gene="IGHG"
BASE COUNT          114 a          139 c          152 g          100 t
ORIGIN      
        1 acatggggag catcacacaa caaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggatcct cctcttggtg gcagcagcta caggcgccca
      121 ctctgaggtc caactggtgc agtctggggc tgaggtgaag aagcctgggg cctcagtgaa
      181 ggtctcctgc aaggtttccg gagacacctt caccgaatta tccatgcact gggtgcgaca
      241 ggcccctgga aaagggcttg agtggatggg aggtgttgat cctgcaagtg atgaagtaat
      301 acacgcagat ggtttccagg gcagagtcac catgaccgag gacacgtcta cagacacagc
      361 ctacatggag ctgagcggcc tgagatctga ggacacggcc gtgtattact gtgcgagagg
      421 gaggttcggt agtagcgtct ggtccaatct cgtctatggt ttcgattcct ggggccaagg
      481 ggtcgtcgtc accgtctcct cagcc
//
LOCUS       KCXD01007619             495 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1117:18618:12059
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007619
VERSION     KCXD01007619.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 495)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 495)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1117:18618:12059"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    115..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        115..489
     V_segment       115..408
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <400..>462
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66101.1"
                     /translation="CARGTTHLEAAAGVGDYFDYW"
     D_segment       430..437
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>495
                     /gene="IGHG"
BASE COUNT          109 a          141 c          147 g           98 t
ORIGIN      
        1 acatggggga accacgtccc tcctctaaag aagcccctgg gaacacagct catcaccatg
       61 gacttgacct ggaggctcct ctttgtggtg gcagcagcta caggtgccca gtcccaggtc
      121 cagctggtgc agtccggggc tgaggtgaag aagcctgggg cctcagtgaa gctctcctgc
      181 aaggcttctg gatacacctt caacatccat gccatcagtt gggtgcgaca ggcccctgga
      241 caagggcttg agtggatggg agggatcatc ccttttgttg atatgacaag ttacgcacag
      301 aagttccagg gcagagtcac gattaccgcg gacacgtcca taactacatc ctacatggag
      361 ctgaccagcc tgacatctga ggacacggcc gtgtattact gtgcgagagg gacaacccac
      421 ctcgaggcgg cggctggagt cggagactac tttgactact ggggccaggg agtcctggtc
      481 accgtctccg cagcc
//
LOCUS       KCXD01007620             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7543:2484
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007620
VERSION     KCXD01007620.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7543:2484"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66102.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       442..447
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          114 a          116 c          152 g          121 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttcag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttatg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggagtg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01007621             498 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:10717:18600
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007621
VERSION     KCXD01007621.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:10717:18600"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    136..496
                     /note="immunoglobulin heavy chain variable region"
     V_region        136..496
     V_segment       136..429
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>465
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66103.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       430..434
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..496
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        497..>498
                     /gene="IGHG"
BASE COUNT          106 a          123 c          155 g          114 t
ORIGIN      
        1 acatgggggg agaggagccc agccccagaa ttcccaggtg tttctgttcg gcgatcagca
       61 ctaaacacag aacataccat ggagtttgtg ctgagctggg ttttccttgt tgctcttttg
      121 aaaggtgtcc agtgtgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg
      181 gggtccctga gactctcctg cgcagcctct ggattcaact tcaattacta ctacattaac
      241 tgggtccgcc aggctccagg gaaggggctg gagtggatct caggtattga cagtggtgga
      301 catagcacat actatgcgga ctccgtgaag ggcagattca ccatctccag agagaacgcc
      361 aagaacacac tgtatcttca aatggacagc ctgagagctg aggacacggc tgtctattac
      421 tgtgcgagag tggtgggtgg tgccgcagga tacttcgact tctggggcca gggcgccctg
      481 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007622             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:8082:15171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007622
VERSION     KCXD01007622.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:8082:15171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66104.1"
                     /translation="CVRDSYGRGFDQW"
     D_segment       438..445
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          111 a          112 c          151 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcag cttcagtaac tctggcattc
      241 actgggtccg ccaggctcca ggggaggggc tggagtgggt gtcagttata tcgtatgatg
      301 aaagtaagac atactacgca gactctgtga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacat ggtacatctt caaatgaaca ccctgaattt ggaggacacg gccgtatatt
      421 actgtgtgag agattcttac ggtagaggct ttgaccagtg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007623             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1114:24206:2217
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007623
VERSION     KCXD01007623.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1114:24206:2217"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..473
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66105.1"
                     /translation="CARYSYGSNYFFGFFDYW"
     D_segment       398..406
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..473
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT           93 a          136 c          131 g          115 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgttc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagttcccaa atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccctcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcagtaact cctggagctg gatccgccag tccccaggga agggactgga
      241 gtggatcggt tatgtctatg gtgatagtgg gaacaccgaa tacaacccct ccctcaagag
      301 tcgagtcacc atttcaagag actcgtccaa gaatcagttt tccctgaagc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtatcactg tgcgagatac agttacggtt ccaactactt
      421 ctttgggttc tttgactatt ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007624             475 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14922:6050
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007624
VERSION     KCXD01007624.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 475)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 475)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14922:6050"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    119..473
                     /note="immunoglobulin heavy chain variable region"
     V_region        119..473
     V_segment       119..398
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>442
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66106.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       409..421
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..473
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        474..>475
                     /gene="IGHG"
BASE COUNT          107 a          144 c          136 g           88 t
ORIGIN      
        1 acatggggac acaacaacca catccctccc ctacagaagc cccagagcac agcacctcac
       61 catggactgg acctggagga tcctcctctt ggtggcagca gctacaggcg cccactctga
      121 ggtccttctg gtgcagtctg gggctgaggt gaagcagcct ggggcctcag tgaaggtctc
      181 ctgcaaggtt tccggataca ccctcaccga agtgtccact cactgggtgc gacaggcccc
      241 cggaaaaggg cttgagtggg tgggaagtgt tgatcctgca tatggtgaaa tgaagttcca
      301 gggcagagtc accatgaccg aggacacgtc cacagacaca gcctacatgg aactgagcag
      361 cctaagatct gaggacacgg ccgtgtatta ctgtgcgatt ggccctaccg gcaggtggaa
      421 cggctggtcc ttcgatatct ggggccctgg caccccaatc accatctcct cagcc
//
LOCUS       KCXD01007625             488 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:10804:9240
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007625
VERSION     KCXD01007625.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:10804:9240"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..486
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..486
     V_segment       120..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>455
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66107.1"
                     /translation="CATSSSGTWLYWYFDIW"
     D_segment       425..431
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..486
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        487..>488
                     /gene="IGHG"
BASE COUNT          120 a          138 c          136 g           94 t
ORIGIN      
        1 acatggggga cacaacaacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg atcctcctct tggtggcagc agcgacaggc gcccactctg
      121 aggtccagct ggtgcagtct ggggctgagg tgaagaagcc tggggcctca gtgaaggtct
      181 cctgcaaggt ttccggatac atcttaaccg aattatccat gcactgggtg cgacaggccc
      241 ctggaaaagg gcttgagtgg atgggaagtg ttgatcctca atatggtgaa atgatagacg
      301 cagagaaatt ccagggcaga gtcaccatga ccgaggacac gtctacagac acagcctaca
      361 tggagctgag cagtctgaga tctgaggaca cggccgtgta ttactgtgcg acatcatcca
      421 gcggcacctg gctatattgg tacttcgata tctggggccc tggcacccca atcaccatct
      481 cctcagcc
//
LOCUS       KCXD01007626             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:22953:13390
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007626
VERSION     KCXD01007626.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:22953:13390"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66108.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       439..453
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          114 a          115 c          145 g          123 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaagagg tgtccggtgt gaggtccaac tggtggagtc tggaggaggc ttggttcaac
      181 ctggggggtc cctgagactc tcctgtgcag cctctggatt caccttcagt aactttggca
      241 tacactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt atttcgtctg
      301 atggaagtaa caaatactac gcaaactctg tgaagagccg attcaccatc tccagagaca
      361 attccaagaa cacactttat cttcaaatga acaacttgaa attggaggac acggccgtct
      421 attactgtgc gagagatgat attgggactg gttttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007627             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2111:20367:6225
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007627
VERSION     KCXD01007627.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2111:20367:6225"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..416
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66109.1"
                     /translation="CARAHSGSWTNWYFDLW"
     D_segment       421..435
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       439..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          121 a          142 c          138 g           90 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcatagcacc
       61 tcaccatgga ctggacctgg agggtcctcc tcttggtggc agcaactaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gccaggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tatacggtca ccgaaatatc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tctatatggt gaactaatag
      301 aaggagagaa gttcccgggc agagtcacca tgaccgagga cacgtccaca gacacagcct
      361 acatggaact gagcagcctg agatctgagg acacggccgt ctattactgt gcgagagccc
      421 atagcggcag ctggaccaac tggtacttcg atctctgggg ccctggcact ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01007628             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:3879:10260
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007628
VERSION     KCXD01007628.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:3879:10260"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..428
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66110.1"
                     /translation="CAASYLGYGFEYW"
     D_segment       434..440
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          118 c          146 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga ggtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcat cttcaatacc tatgccatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgcatgatg
      301 gaactaagaa atactacata gactctgtga aggaccgatt caccatctcc agagacaatt
      361 ccaagaacat acaatatctt cacatgaaca acctgaaatt ggaggacacg gccatatact
      421 actgtgcggc ctcctacttg gggtacggat ttgagtactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007629             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15986:11752
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007629
VERSION     KCXD01007629.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15986:11752"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..472
     V_segment       121..412
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66111.1"
                     /translation="CAIQGNSQFDYW"
     D_segment       419..424
                     /gene="IGHD1-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       430..472
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT          109 a          135 c          138 g           92 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaagctc
      181 tcctgcaagg cttctggata cagcttcaac atcgatgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgtcggtat aacaaactac
      301 gcacagaggt tccagggcag agtctcgatt accgcggaca cgtccacaag cacagcctac
      361 atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gatccaaggg
      421 aacagccagt ttgactactg gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007630             472 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:13642:18335
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007630
VERSION     KCXD01007630.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 472)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 472)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:13642:18335"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    107..470
                     /note="immunoglobulin heavy chain variable region"
     V_region        107..470
     V_segment       107..400
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <392..>439
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66112.1"
                     /translation="CVRYEDEAINYHFDFW"
     D_segment       404..411
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       426..470
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        471..>472
                     /gene="IGHG"
BASE COUNT           96 a          137 c          131 g          108 t
ORIGIN      
        1 acatgggggg aaatgctctc tgagagtcat ggacctcctg tgcaagaaca tgaagcacct
       61 gtggttcttc cttctcctgg tggcagctcc cagatgggtc ctgtcccagg tgcagctgca
      121 ggagtcgggc ccaggactgg tgaagccttc ggagaccctg tccctcacct gcgttgtctc
      181 tggtgactcc atcaccagta gctactggaa ctggatccgc cagccccccg ggaagggact
      241 ggaatggatt gggtatatct ctggtgctta tgggagcacc agctacaacc cctccctcaa
      301 gagtcgagtc agcatttcaa cagacacgtc caagaaccag ttttccctga ggctgagttc
      361 tgtgaccgcc gcggacaccg ccgtgtatta ctgtgtgaga tatgaggatg aagccattaa
      421 ctaccacttt gacttctggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007631             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:10595:8101
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007631
VERSION     KCXD01007631.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:10595:8101"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66113.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       448..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          110 a          121 c          161 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcttga caaagcctgg
      181 ggggtccctg agactctcct gtgcggcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggggtgggtc tcacgaatca gtcatgatgg
      301 tgatagcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagaatgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gaggacacag ccgtatatta
      421 ctgtgcgaga gagcgttttg ggggaattgg ggtgattatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01007632             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:18445:5988
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007632
VERSION     KCXD01007632.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:18445:5988"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66114.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       401..410
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           82 a          137 c          139 g          103 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcacggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccacct cctggtggtt gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gctccatcag tggttactgg tggggctgga tccgccagtc cccagggaag ggactggagt
      241 ggattgggtt tttcggtggt agtggtggga acacctacta caagtcctcc ctccagagtc
      301 gagtcgccat ttcaaccgac acgtccaaga accagttctc cctgatactg acctctgtga
      361 ccgccgcgga cacggccctc tattactgtg cgagggggaa tatagcagcg actggcattg
      421 actactgggg ccagggactc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007633             519 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:21458:16856
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007633
VERSION     KCXD01007633.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:21458:16856"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    139..517
                     /note="immunoglobulin heavy chain variable region"
     V_region        139..517
     V_segment       139..429
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <421..>486
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66115.1"
                     /translation="CARALVAVVSTRTKYYYGLDSW"
     D_segment       442..450
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..517
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        518..>519
                     /gene="IGHG"
BASE COUNT          111 a          122 c          156 g          130 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctggg attcccaggt gttttcattc agagatcagg
       61 actgaacaca caggactcac catggagtct atgctgagct gggttttcct tgttgctata
      121 ttaaaaggtg tccagtgtgt ggagcagctg gtggagtctg ggggaggctt ggtacagcca
      181 ggggcgtccc tgagactctc ctgcgcagcc tctgaatcca gcttcactag ctatgacatg
      241 cactggtttc gccaggctcc agggaagggt ctggagtggg tatcaggtat tggcattggc
      301 ggtgccacat actacccaga ctctgtgaag ggtcgattca ccatctccag agacaatgcc
      361 aggaactcct tgtctcttca aatgaacagt ctgagagctg aggacagtgg tgtgtattat
      421 tgtgcaagag ctcttgtagc ggtggtgtct actagaacca aatattacta cggtttggat
      481 tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007634             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:17522:18017
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007634
VERSION     KCXD01007634.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:17522:18017"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66116.1"
                     /translation="CARYEDEYSDYYFDYW"
     D_segment       406..421
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           94 a          138 c          134 g          103 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagagcatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tggctccatc agcaatagct actggaactg gatccgccag cccccaggga aggggctgga
      241 gtggattggg tctatctatg gtggtactgg gagcgccgcc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagtta tccctgaagc tgacctctgt
      361 gaccggcgcg gacaccgccg tgtattactg tgcgagatat gaggatgaat acagtgacta
      421 ctactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007635             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:8091:11919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007635
VERSION     KCXD01007635.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:8091:11919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    114..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        114..483
     V_segment       114..407
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66117.1"
                     /translation="CAREYCTSSTCAGFLDYW"
     D_segment       408..415
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT          110 a          135 c          137 g          103 t
ORIGIN      
        1 acatggggaa ccacatccct cctctaaaga agcccctggg agcacagctc atcaccatgg
       61 actggacctg gaggctcctc tttgtggtgg cagcagctgc aggtgtccag tcccaggtcc
      121 gcctggtgca gtccggggct gaggtgaaga agcctggggc ctcagtgagg atttcctgcg
      181 gggcttctgg attcaccctc gacacctatg gtatcaactg ggtgcgacag gcccctggac
      241 aagggcttga gtggatggga gtgatcatcc cccttattgg tatcataaac tacgaaaaga
      301 actctcaggg cagagtcaca ataaccgcga acacgtccac aaatacagcc tatatggaac
      361 tgagcagtct gagatctgag gacacggcca tctattactg tgcgagagaa tactgcactt
      421 ctagtacttg cgccgggttc cttgactact ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01007636             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:18884:9980
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007636
VERSION     KCXD01007636.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:18884:9980"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..499
     V_segment       121..414
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66118.1"
                     /translation="CARVLGYNNKYEVTRGRLDYW"
     D_segment       441..448
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       458..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          119 a          142 c          140 g          100 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagc tggtgcagtc cggggctgag gtgaagaagc ctggggcctc agtgaacctc
      181 tcctgcaagg cttctggata ccccttcaac atctatgcca tcaattgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttggcat gacaaactac
      301 gcacagaagt tccagggcag agtcaccatt accgcggaca cgtccacaag tacagcctac
      361 atagaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagtctta
      421 gggtacaata acaagtacga agttaccagg ggccgtcttg actactgggg ccagggagtc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007637             471 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:5456:14921
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007637
VERSION     KCXD01007637.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 471)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 471)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:5456:14921"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..469
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..469
     V_segment       112..404
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>438
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66119.1"
                     /translation="CARRPWSADAFDFW"
     D_segment       410..415
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..469
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        470..>471
                     /gene="IGHG"
BASE COUNT          108 a          107 c          139 g          117 t
ORIGIN      
        1 acatggggca cagtgttcca ttcggtgatc agcacagaac acagaggact caccatgaag
       61 tttgggctga gctgggtttt ccttgttgct attttaagag gtgtccagtg tgaggtgcag
      121 ctggtggagt ctggaggagg cttggttcag cctggggggt ccctgagact ctcctgtgca
      181 gcctctggat tcaccttcag tagctatggc atgcactggg tccgccaggc tccagggaag
      241 gggctggagt gggtggcagt tatatcatac gatgaaaata agaaatacta cgcagactct
      301 ctgagggacc gattcaccat ctccagagac aattccaaga acatgcttta tcttcaaatg
      361 aacaacctga aattggagga cacggccgtt tattactgtg cgaggaggcc ctggagtgca
      421 gatgcttttg atttctgggg ccaaggactc agggtcaccg tctcttcagc c
//
LOCUS       KCXD01007638             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1111:25641:5894
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007638
VERSION     KCXD01007638.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1111:25641:5894"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..500
     V_segment       146..439
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <431..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66120.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       441..445
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          107 a          121 c          152 g          122 t
ORIGIN      
        1 acatgggggc agctctggga gaggagccca gccctggaag tccacagtgt tccattcggt
       61 gatcagcaca gaacacagag gactcaccat gaagtttggg ctgagctggg ttttccttgt
      121 tcctatttta agaggtgtcc agtgtgaggt gcagctggtg gagtctggag gaggcttggt
      181 tcagcctggg gagtccctga gactctcctg tgcagcctct ggattcccct tcagtacctc
      241 tggcatgcac tgggtccgcc aggctccagg gaaggggctg gagtgggtgt ctgtaatttc
      301 gtctgatgaa agtaagaaat actacgcaga ctctgtgaag gaccgattca ccatctccag
      361 agacaactcc aagaacatac tatttcttca aatgaacaac ctgaaattgg aggacacggc
      421 cgtgtatttc tgtgtgagag atgccttcgg gggcggtttg gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007639             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:22151:14153
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007639
VERSION     KCXD01007639.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:22151:14153"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66121.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       414..419
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          113 a          142 c          129 g           92 t
ORIGIN      
        1 acatggggga cacaaccacc acatccctcc cctacagaag ccccagagca cagcacctca
       61 ccatggactg gacctggagg ctcctcctct tggtggcagc agctacaggc gcccactccg
      121 aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcctcc gtgaaaatct
      181 cctgccaggc ttccggatac accttaaccg accactacct acactgggtg cgacaggctc
      241 ctggaaaagg acttgagtgg atgggaggta ttcttcctga gtatggtaaa gttgactaca
      301 cacagaagtt ccaagacaga gtcaccatca ccgcggacat gtcgacagag acagtctaca
      361 tggagctgag cagcctgaga tctgaggaca cggccgttta ttactgtgtg acagtgggtc
      421 cctaccatta ctttgactac tggggccagg gagccctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007640             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:6564:9078
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007640
VERSION     KCXD01007640.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:6564:9078"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66122.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          114 a          145 c          131 g           91 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg aggtgttcat cctgaatatg gtaaagtgga
      301 ctacacacag aagttccgag acagactcac catcaccgcg gacatgtcga cagagacagc
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc gtttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01007641             282 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:21915:12561
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007641
VERSION     KCXD01007641.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 282)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 282)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:21915:12561"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..276
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..276
     V_segment       8..187
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <181..>249
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66123.1"
                     /translation="CATGVYYQDENGYFYVGGDFDYW"
     D_segment       196..209
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       236..276
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        277..>282
                     /gene="IGHG"
BASE COUNT           67 a           68 c           87 g           60 t
ORIGIN      
        1 acatggggac aggcccctgg acaagggctt gggtggatag gagggatcat ccctcttgtt
       61 ggtatgacaa actacgaaca ggagttccag ggcagagtca cgattaccgc ggacacgtcc
      121 acgaatacag tcttcatgga actgagcagc ctgagatcgg aggacacggc cgtctactat
      181 tgtgcgacag gggtatatta ccaggatgaa aacggttatt tttatgtcgg cggggacttt
      241 gactactggg gccagggagt cctggtcacc gtctccccag cc
//
LOCUS       KCXD01007642             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:15040:6913
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007642
VERSION     KCXD01007642.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:15040:6913"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66124.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       440..446
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          117 a          115 c          146 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt cttgctattt
      121 taagaggtgt ccagtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcagccgg
      181 gggggtccct gacactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt gacagttata tcgtatgatg
      301 aaagtaagaa atactacgca gactctctga aggaccgatt caccatttcc agagacaatt
      361 ccaagaacac gctatatctt caaatgaaca acctgcaatt ggaagacacg gccgtgtatt
      421 actgtgcgag agatgataat ggggtgctta tcgacttctg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007643             485 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:26264:10469
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007643
VERSION     KCXD01007643.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:26264:10469"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..483
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..483
     V_segment       105..412
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>452
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66125.1"
                     /translation="CASADSGFPPYFFDFW"
     D_segment       416..424
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..483
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        484..>485
                     /gene="IGHG"
BASE COUNT           86 a          142 c          138 g          119 t
ORIGIN      
        1 acatggggaa atgttctctg agagtcacgg acatcctgtg caggaacatg aagcacctgt
       61 ggttcttcct cctcctggtg gcagctccca gatgggtcct gtcccagctg cagctgcagg
      121 agtcgggccc aggacttgtg aagccttcgg agaccctgtc tgtcacctgc gctgtctctg
      181 gtggctctat cagcagtacc aactggagct ggatccgcca ggccccaggg aagggactgg
      241 aatggattgg gtgtatcttt ggtggtggta tctttggtgg tggtagtaac acccagtaca
      301 gcccctccct caagagtcga gtcacccttt cagtagacgc gtccaagaac caactctccc
      361 tgcagctgac gtctgtgacc gccgcggaca cggccatcta tttctgtgcg agcgctgata
      421 gtggttttcc tccctacttc tttgacttct ggggccaggg agtcctggtc accgtctcct
      481 cagcc
//
LOCUS       KCXD01007644             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:10185:7263
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007644
VERSION     KCXD01007644.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:10185:7263"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66126.1"
                     /translation="CARDVYGRGFDYW"
     D_segment       444..451
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          112 a          114 c          155 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ttattttaag aggtgtccag tgtgaagtac agctggtgga gtctggagga ggcttggctc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccgtc agtaactttg
      241 gcgttcactg ggtccgccag gctccaggga aggggctgga ctgggtgaca gtgatatcgt
      301 atgatggaaa taagaaatac tacgcagagt ctgtgaaggg ccgattcacc atctccagcg
      361 acacttccaa gaacgtggta tatcttcaaa tgaacaacct gaaattggcg gacacggccg
      421 tgtattactg tgcgagagat gtttacggta ggggatttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007645             499 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:9858:10096
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007645
VERSION     KCXD01007645.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 499)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 499)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:9858:10096"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..497
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..497
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>466
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66127.1"
                     /translation="CVRDAFGGGLDSW"
     D_segment       438..442
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       451..497
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        498..>499
                     /gene="IGHG"
BASE COUNT          107 a          118 c          153 g          121 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgtttc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctggggag tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctctgg
      241 catgcactgg gtccgccagg ctccagggaa ggggccggag tgggtgtctg taatttcgtc
      301 tgatggaagt aagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caactccaag aacatactat atcttcaaat gaacaacctg aaattggagg acacggccgt
      421 gtatttctgt gtgagagatg ccttcggggg cggtttggat tcctggggcc aaggggtcgt
      481 cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007646             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10642:12124
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007646
VERSION     KCXD01007646.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10642:12124"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    121..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        121..502
     V_segment       121..413
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <406..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66128.1"
                     /translation="CASGGFEDDNGHYYTTLTFHDW"
     D_segment       423..446
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..502
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          114 a          140 c          144 g          106 t
ORIGIN      
        1 acatggggac ataacaacca cgtccctcct ctaaagaagc ccctgggaac acagctcatc
       61 accatggact tgacctggag gctcctcttt gtggtggcag cagctacagg tgcccagtcc
      121 caggtccagt tggtgcagtc cggggctgag gtgaagaggc ctggggcctc agtgaagctc
      181 tccttcaagg ctcctggata catcttcagc atatctgcca tcagttgggt gcgacaggcc
      241 cctggacaag ggcttgagtg gatgggaggg atcatccctc ttgttggtgt aacaacctac
      301 gcacagaagt tccaggacag agtcacgatt accgcggaca cgtccacaag cacagcctac
      361 atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagtggcggc
      421 ttcgaggatg ataacggtca ctattatacg acactaacat ttcacgattg gggccaggga
      481 gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007647             459 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12655:7766
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007647
VERSION     KCXD01007647.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 459)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 459)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12655:7766"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..457
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..457
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>426
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66129.1"
                     /translation="CARRWAGYGLDSW"
     D_segment       403..408
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       409..457
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        458..>459
                     /gene="IGHG"
BASE COUNT           85 a          136 c          137 g          101 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac atcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggc agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccctca gcggttacta ctggagctgg atccgccagc ccccagggaa ggggctggag
      241 tggattgggt atatcgctgg tagcagtggg agcaccgact ataatccctc cctcaagagt
      301 cgagtcacca tttcaacaga cacgtccaag aatcagttct ccctgaatct gatctctgtg
      361 accgccgcgg acacggccgc atattactgt gcgaggcgat gggctggata cggtttggat
      421 tcctggggcc aaggggtcgt cgtcaccgtc tcctcagcc
//
LOCUS       KCXD01007648             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:7353:14125
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007648
VERSION     KCXD01007648.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:7353:14125"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66130.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          105 a          114 c          156 g          125 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtcctg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaag tagcatatac tacgcagcct ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaagtttgag gacacggccg
      421 tgtattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007649             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:13464:10594
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007649
VERSION     KCXD01007649.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:13464:10594"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66131.1"
                     /translation="CARDVYGSGLDYW"
     D_segment       447..454
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          106 a          116 c          153 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gttttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtcctg tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctcgggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagttttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatgtcgt
      301 ctgatggaag taacatatac tacgcagccc ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgtta tatcttcaaa tgaacaacct gaaatttgag gacacggccg
      421 tctattactg tgcgagagat gtgtacggta gtgggttaga ctactggggc ctgggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007650             493 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:26234:14738
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007650
VERSION     KCXD01007650.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 493)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 493)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:26234:14738"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    131..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        131..491
     V_segment       131..421
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <413..>460
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66132.1"
                     /translation="CAKGETASVYYGLDSW"
     D_segment       435..440
                     /gene="IGHD5-29"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       443..491
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>493
                     /gene="IGHG"
BASE COUNT          106 a          127 c          145 g          115 t
ORIGIN      
        1 acatggggga gcccagcact ggaagtccac agtgttccat tcggtgatca gcactgaaca
       61 cagaggactc accatggagt ctgggctgag ctgggttttc cttgttgcta ttttaagagg
      121 tgtccagtgt gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctgggggatc
      181 cctgagactc tcctgtgcag cctctggatt caccttcagt acctattcta tacactgggt
      241 ccgccaggct ccagggaagg ggctggagtt ggtctcagct attagtactg ctggtagcac
      301 atactacaca gactccgtga agggccgatt caccatctcc agagacaact caaagaacac
      361 gctctccctg caaatgaaca gcctgagagt tgaggacacg gccctgtatt actgtgcgaa
      421 aggggagaca gcctcagttt attacggttt ggattcctgg ggccaagggg tcgtcgtcac
      481 cgtctcctca gcc
//
LOCUS       KCXD01007651             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1108:24087:11691
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007651
VERSION     KCXD01007651.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1108:24087:11691"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66133.1"
                     /translation="CATSPSGNWLFWYFDFW"
     D_segment       422..428
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       441..489
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          114 a          141 c          137 g           99 t
ORIGIN      
        1 acatggggga tcacacaaca gccacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctgca ggcgcccgct
      121 ctgaggtcca gctggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcga ggtttccgga tacaccttca ccgaactgtc catccactgg gtgcgacagg
      241 cccctggaaa aggccttgag tggatgggaa gtgttgatcc tgaatatggt gaaatgataa
      301 acgcagaaaa gttccagggc agagtcacct tgaccgagga cacgtctaca ggaacggcct
      361 acatggagct gatcagcctg agatctgaag acacggccgt atattactgt gcgacatcac
      421 ccagcggcaa ttggcttttt tggtacttcg atttttgggg ccctggcacc ccaatcacca
      481 tctcctcagc c
//
LOCUS       KCXD01007652             461 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:7222:8328
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007652
VERSION     KCXD01007652.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 461)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 461)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:7222:8328"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..459
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>428
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66134.1"
                     /translation="CARDEDPSIFDYW"
     D_segment       409..413
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>461
                     /gene="IGHG"
BASE COUNT           92 a          138 c          130 g          101 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggaca tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 gcgccatcag cagtggtttc tactggacct ggatccgcca acccccagag aaggggctgg
      241 agtggattgg gtgtatcggt ggtaatagtg gtaccaccta ctacaacccc tccctcaaga
      301 gtcgagccac catttcaaaa gacacgtcca acaatcaact ctccctgaag gtgagttctg
      361 tgaccgccgc ggacacggcc gtgtattact gtgcgagaga tgaagacccc tccatttttg
      421 actactgggg ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007653             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:11552:7213
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007653
VERSION     KCXD01007653.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:11552:7213"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66135.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       437..442
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..492
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          106 a          115 c          157 g          116 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg aggaggcttg gttcagccgg
      181 gagggtccct gagactctcc tgtgcagcct ctggattcag cttcagtatc tctggcatgc
      241 actgggtccg ccaggctcca gggaaggggc tggaatgggt ggcagttgaa tcgtttgatg
      301 gaactaagaa attctacgca gactctgtga aggaccgatt caccatctcc agagacagtt
      361 ccaggaacat gctgtatctt caaatgaaca acctgaaact ggaggacacg gccgtctatt
      421 actgtgtgag agatgcctac gggggcggtt tggattcctg gggccaaggg gtcgtcgtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007654             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:12998:10615
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007654
VERSION     KCXD01007654.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:12998:10615"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    120..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        120..474
     V_segment       120..413
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <405..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66136.1"
                     /translation="CARDVWGRGFDFW"
     D_segment       416..421
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       432..474
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          102 a          105 c          149 g          120 t
ORIGIN      
        1 acatgggctg gaagtccaca gtgttccatt cggtgatcag cacagaacac agaggactca
       61 ccatgaagtt tgggctgagc tgggttttcc ttgttgctat tttaagaggt gtccagtgtg
      121 aggtgcggct ggtggagtct ggaggaggct tggttcagcc gggggggtcc ctgagactct
      181 cctgtgcagc ctctggattc accttcagta cttttggcat gcactgggtc cgccaggctc
      241 cagggaaggg gctggagtgg gtggcagtta catcgtctga tgaaactaag aagtattatg
      301 cagactctgt gaaggcccga ttcaccgtct ccagagacaa ttccaagaac atgttatatc
      361 ttcaaatgga caacctgaaa ttggaagaca cggccgtgta ttattgcgcg agagatgtct
      421 gggggagggg atttgacttt tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007655             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:14302:16178
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007655
VERSION     KCXD01007655.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:14302:16178"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..462
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..462
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66137.1"
                     /translation="CARYSDTDSYYFFDYW"
     D_segment       409..419
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..462
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        463..>466
                     /gene="IGHG"
BASE COUNT           92 a          138 c          128 g          108 t
ORIGIN      
        1 acatgggggc tctctgagag gcatggacct cctgtgcaag aacatgaagc acctgtggtt
       61 cttccttctc ctgctggcag ctcccagatg ggtcctgtcc caggtgcagt tgcaggagtc
      121 gggcccacga ctggtgaagc cttcggagac cctgtccctc acctgcggtg tctctggtga
      181 ctccatcagc agtaccttct ggagctggat ccgccagccc ccagggaagg ggctggagtg
      241 gattggctat atctatggtg ctactgggag caccggctac aacccctccc tcaagagtcg
      301 agtcagcatt tcaacagaca cgtccaagaa ccagttttcc ctgaaactga actctgtgac
      361 cgccgcggac accgccgtat attactgtgc gagatatagc gatactgata gttattactt
      421 ctttgactac tggggccagg gagtcctggt caccgtctcc tcggcc
//
LOCUS       KCXD01007656             478 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:9906:11088
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007656
VERSION     KCXD01007656.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:9906:11088"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..476
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..476
     V_segment       101..397
                     /gene="IGHV4-79"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>445
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66138.1"
                     /translation="CARVSGRWELFEPGSEDFW"
     D_segment       412..419
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..476
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        477..>478
                     /gene="IGHG"
BASE COUNT           86 a          139 c          143 g          110 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgtaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcagc tgcaggagtc
      121 gggcccagca gtggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagc ggtggttatg gctggagctg gatccgccag gccccaggga agggactgga
      241 gtggattggt tttatctatg gtactggtgg tagcacctac tacacaccct ccctcaagag
      301 gcgactcacc atttcagcgg acacgtccaa gaaccagttc tccctccatc tgacctctgt
      361 taccgccgcg gacacggcca tgtattactg tgcgagagtt tcgggcaggt gggaactatt
      421 tgagcctggg tcagaggact tctggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007657             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:4847:8812
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007657
VERSION     KCXD01007657.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:4847:8812"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..489
     V_segment       138..430
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <423..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66139.1"
                     /translation="CANALTGGLDYW"
     D_segment       436..444
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       448..489
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          104 a          123 c          157 g          107 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
      181 gggggtccct gagactctcc tgtacagcct ctggattcac cttcagtaga tactggatga
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctatt actagtggtg
      301 gagatagtac gtactacgca gactccgtga agggccgatt caccatctcc agagacaact
      361 caaagaacac gctctccctg caaatgaaca gccttagagc ggaggacacg gccgtgtatt
      421 actgtgcgaa cgcgttaact ggggggcttg actactgggg ccagggagtc ctggtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01007658             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:3705:11442
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007658
VERSION     KCXD01007658.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:3705:11442"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66140.1"
                     /translation="CTRYGGDRGDWYFDYW"
     D_segment       417..423
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           92 a          138 c          138 g          101 t
ORIGIN      
        1 acatggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga
      121 gtcgggccca ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgg
      181 tgactccatc agcagtagct actggagctg ggtccgccag cccccaggga aggggctgga
      241 ctggattggg tatatctatg gtggtagtgg gagcaccggc tacaacccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaaac tgaactctct
      361 gaccgccgcg gacaccgccg tgtattactg cacgagatat gggggagatc ggggcgactg
      421 gtactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007659             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:11923:12284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007659
VERSION     KCXD01007659.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:11923:12284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66141.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       450..456
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          119 a          112 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctgttttaag aggtgtccag tgtgaggtac aattagtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactatg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 ctgatggaag taagacatac tacgcaaact ctgtgaagga ccgattcacc atattaagag
      361 acaattccaa gagcatgctc tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tctattattg tgcgagagac gatatgggaa gtggctttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007660             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:11559:19721
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007660
VERSION     KCXD01007660.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:11559:19721"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..490
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..490
     V_segment       123..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66142.1"
                     /translation="CAAGLGGYLLHTEYFEFW"
     D_segment       429..438
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       442..490
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        491..>494
                     /gene="IGHG"
BASE COUNT          116 a          136 c          144 g           98 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aagtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga aaaaccttca ctgaattatc cattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatct tgcatatgat gaaataatgg
      301 acgcagagaa gttccagggc agagtcacca tgaccgagga cacgtctaca gacacagcct
      361 acatggagct gagcagcctg agatctgagg acacggccgt gtattactgt gcggcgggcc
      421 ttgggggata tttactgcat actgaatact tcgagttctg gggccagggc gccctggtca
      481 ccgtctcctc cgcc
//
LOCUS       KCXD01007661             474 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19473:10866
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007661
VERSION     KCXD01007661.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 474)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 474)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19473:10866"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    100..472
                     /note="immunoglobulin heavy chain variable region"
     V_region        100..472
     V_segment       100..393
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>441
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66143.1"
                     /translation="CAREKYYSGSYKHNWFDVW"
     D_segment       400..417
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       422..472
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        473..>474
                     /gene="IGHG"
BASE COUNT           96 a          135 c          136 g          107 t
ORIGIN      
        1 acatggggct ctctgagagt cacggacatc ctgtgcaaga acatgaagca cctgtggttc
       61 ttcctcctcc tggtggcagc tcccagatgg gtcctgtccc aggtgcagct gcaggagtcg
      121 ggcccaggac tggtgaggcc ttcggagacc ctgtccctca cctgcggtgt ctctggtggc
      181 tccttcagcg gtttctattg gagctggatc cgccagtccc cagggaaggg actggagtgg
      241 attgggtata tcagtgctag tagtgggagt accgactaca acccctccct caagagtcga
      301 gtcaccattt caacagacac gtccaataac cagttctccc tgaagctgac ctctgtgacc
      361 gccgcggaca cggccgtgta ttactgtgcg agagagaaat actatagtgg tagttataaa
      421 cacaactggt tcgatgtctg gggcccggga gtccaggtca ccgtctcctc agcc
//
LOCUS       KCXD01007662             361 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1116:27053:10311
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007662
VERSION     KCXD01007662.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 361)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 361)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1116:27053:10311"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    8..359
                     /note="immunoglobulin heavy chain variable region"
     V_region        8..359
     V_segment       8..297
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <293..>328
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66144.1"
                     /translation="CAGGAYANLDYW"
     D_segment       308..312
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       320..359
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        360..>361
                     /gene="IGHG"
BASE COUNT           79 a           95 c          112 g           75 t
ORIGIN      
        1 acatggggag gtgcaaatgg tggagtctgg gggcggcttg gcaaagcctg gggggtccct
       61 gagactctcc tgtgcagcct ctggattcac cttcagtaga tactggatga actgggtccg
      121 ccaggctcca ggaaaggggc tggagtgggt ctcagctctt aattatgatg gggatagtac
      181 atactacgca gactccgtga agggccgatt caccatctcc agagacaact caaagaacac
      241 gctctccctg caaatgcaca gcctgagaga agatgacacg gccgtttatt tctgtgcggg
      301 cggggcgtac gctaacctcg actactgggg ccagggagtc ctggtcaccg tctcctcagc
      361 c
//
LOCUS       KCXD01007663             442 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:17371:9119
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007663
VERSION     KCXD01007663.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 442)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 442)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:17371:9119"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    74..440
                     /note="immunoglobulin heavy chain variable region"
     V_region        74..440
     V_segment       74..367
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <359..>409
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66145.1"
                     /translation="CARVGEDSGGAEDLDFW"
     D_segment       377..384
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       399..440
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        441..>442
                     /gene="IGHG"
BASE COUNT           97 a           98 c          135 g          112 t
ORIGIN      
        1 acatggggga ctcaccatga agtttgggct gagctgggtt ttccttgttg ctattttaag
       61 aggtgtccag tgtgagatac aactggtgga gtctggagga ggcttggttc agcctggggg
      121 gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctttg gcatgcactg
      181 ggtccgccag gctccaggga agggactgga atgggtggca cttatatcgt atgatggaga
      241 taagaaatac tacgcagact ctgtgaagga ccgattcacc ctctccagag acaattccga
      301 gaacatccta tatcttcaaa tgtacaacct gaaattggag gacacggccg tgtatttctg
      361 tgcgagagtt ggagaggata gtggtggtgc ggaggacctt gacttctggg gccaaggagt
      421 cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007664             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:6938:10353
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007664
VERSION     KCXD01007664.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:6938:10353"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66146.1"
                     /translation="CARDAFGSGCDYW"
     D_segment       442..451
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          110 a          117 c          149 g          118 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccactgtgag gtgcaactgg tggagtctgg aggaggcttg gttcggcctg
      181 gggggtccct gagactctcc tgtggagcct ctggattcac cttcagtaat tttggcatcc
      241 actgggtccg ccaggctcca gggaagggcc tggagtgggt ggcagttata tcgtctgatg
      301 aaagtaagaa atactatgca gactctgtga aggaccgatt taccatctcc agagacaatt
      361 ccaagaacat actatatctt caaatgaaca acctgaagtt ggacgacacg gccgtctatt
      421 actgtgcgag agacgcattt ggcagcggct gtgactactg gggccggggc gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007665             512 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:7297:13770
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007665
VERSION     KCXD01007665.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 512)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 512)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:7297:13770"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..510
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..510
     V_segment       144..437
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>479
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66147.1"
                     /translation="CARVPGLVVFTGSLDYW"
     D_segment       448..462
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       469..510
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        511..>512
                     /gene="IGHG"
BASE COUNT          112 a          124 c          155 g          121 t
ORIGIN      
        1 acatggggag ctctaggaga ggagcccagc cctgggattc ccaggtgttt tcatttgtga
       61 tcagcactga acacagaaga ctcatcatgg agtttggcct gagctgggtt ttccttgttg
      121 ctattttaaa aggtgtccag ggtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccatc agtaactact
      241 ggatgtactg ggttcgccag gcaccaggga aggggctgga gtggatctca gccattaata
      301 gtgctgaaag taccacatac tatgcagacg ccgtgaaggg cagattcacc atctccagag
      361 acaacgccaa gaacacactg tatcttcaaa tggacagcct gagagctgag gacacggctg
      421 tctattactg tgcgagagta ccgggcctag tggtgtttac tggttccctt gactactggg
      481 gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007666             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:17340:7238
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007666
VERSION     KCXD01007666.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:17340:7238"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..501
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66148.1"
                     /translation="CARRPWNADAFDFW"
     D_segment       443..450
                     /gene="IGHD1-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..501
                     /gene="IGHJ3-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          114 c          150 g          119 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagac cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccaa tgtgaggtgc agctggtgga gtctggagga gacttggttc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcacgttc agtaactatg
      241 ggatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatatcgt
      301 acgatgaaaa taagaaatac tacgcagact ctctgaagga ccgattcacc atctccagag
      361 acaattccaa gaacatgctt tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tttattactg tgcgaggagg ccctggaatg cagatgcttt tgatttctgg ggccaaggac
      481 tcagggtcac cgtctcttca gcc
//
LOCUS       KCXD01007667             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1103:8215:9689
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007667
VERSION     KCXD01007667.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1103:8215:9689"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..461
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..461
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66149.1"
                     /translation="CARTSGGWSPYFDYW"
     D_segment       397..412
                     /gene="IGHD6-38"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       415..461
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        462..>463
                     /gene="IGHG"
BASE COUNT           89 a          140 c          134 g          100 t
ORIGIN      
        1 acatgggggt tctctgagag tcacggacat cctgtgcaag aacatgaagc acctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agcacctact ggagttggat ccgccagccc ccagggaagg gactggagtg
      241 gattggacgt atctctggtg gtggtgggaa caccgactac aacccctccc tcaagagtcg
      301 agtcaccatt tcaagagaca tgtccaggaa ccaggtctcc ctgcagctga attatgtaac
      361 cgccgcggac agggccgtgt attactgtgc cagaactagc ggtggctggt ccccctactt
      421 tgactattgg ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007668             466 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:16785:16803
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007668
VERSION     KCXD01007668.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:16785:16803"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..464
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..464
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>433
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66150.1"
                     /translation="CVRYEDESINYHFDFW"
     D_segment       398..405
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       420..464
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        465..>466
                     /gene="IGHG"
BASE COUNT           92 a          134 c          129 g          111 t
ORIGIN      
        1 acatgggggc tctctgagag tcatggacct cctgtgcaag agcatgaagc acctgtggtt
       61 cttccttctc ctggtggcag ctcccagatg ggtcctgtcc caggtgcttc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcgctg tctctggtga
      181 ctccatcagc agtagctact ggaactggat ccgccagccc ccagggaagg gactggagtg
      241 gattgggtat atatctggtg cttatgggag caccagctac aatccctccc tcaagagtcg
      301 agtcaccatt tcaacagaca cgtccaagaa ccagttttcc ctgaggctga gttctgtgac
      361 cgccgcggac accgccgtgt attattgtgt gagatatgag gatgaatcca ttaactacca
      421 ctttgacttc tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007669             319 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1101:27586:13664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007669
VERSION     KCXD01007669.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 319)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 319)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1101:27586:13664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..317
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..317
     V_segment       4..256
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <248..>286
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66151.1"
                     /translation="CARDDMGSGFDYW"
     D_segment       269..275
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       276..317
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        318..>319
                     /gene="IGHG"
BASE COUNT           80 a           77 c           89 g           73 t
ORIGIN      
        1 acatgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtaactatgg
       61 catacactgg gtccgccagg ctccagggaa ggggctggag tgggtggcag ttatatcgtc
      121 tgatggaagt aagacatact acgcaaactc tgtgaaggac cgattcacca tattaagaga
      181 caattccaag agcatgctct atcttcaaat gaacaacctg aaattggagg acacggccgt
      241 ctattactgt gcgagagacg atatgggaag tggctttgac tactggggcc agggagtcct
      301 ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007670             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:25225:6439
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007670
VERSION     KCXD01007670.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:25225:6439"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..498
     V_segment       138..428
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <420..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66152.1"
                     /translation="CAKGGSSSFYWYFDIR"
     D_segment       434..441
                     /gene="IGHD6-34"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       446..498
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          104 a          139 c          147 g          110 t
ORIGIN      
        1 acatgggggg gagaggagcc cagcactgga agtccacagt gttccattcg gtgatcacca
       61 ctgaacacag aggactcacc atggagtctg ggctgagctg ggttttcctt cttgctattt
      121 taagaggtgt ccagtgtgag gtgcagctgg tggagtctgg gggcggcttg gcgaagcctg
      181 ggggatccct gagactctcc tgtgcagcct ctggattcac cttcaacacc tatgctatgc
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcagctatt agtactgctg
      301 gtagcacata ctacgcagac tccgtgaagg gccgcttcac cgtctccaga gacaactcaa
      361 agaacacgct ctccctccaa gtgaacagcc tgagacctga ggacacggcc gtgtattact
      421 gtgcgaaagg aggtagcagc tctttctact ggtacttcga tatccggggc cctggcaccc
      481 cagtcaccat ctcctcagcc
//
LOCUS       KCXD01007671             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:20179:12183
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007671
VERSION     KCXD01007671.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:20179:12183"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..512
     V_segment       137..428
                     /gene="IGHV3-122"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66153.1"
                     /translation="CARERFGGIGVIIFNWIDVW"
     D_segment       448..459
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       471..512
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          111 a          121 c          160 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt atttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcacctggt gcagtctggg ggcggcttga caaagcctgg
      181 ggggtccctg agactctcct gtgcggcctc cggattcacc ttcagtgact actatatgga
      241 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcacgaatca gtcatgatgg
      301 tgatagcaca tggtacgcag actccgtgaa gggcagattt accatttcca gagagaatgc
      361 caagaacaca ctgtttcttc aaatggacag cctgagaagt gaggacacag ccgtatatta
      421 ctgtgcgaga gagcgttttg ggggaattgg ggtgattatc ttcaactgga tcgatgtctg
      481 gggcccggga gtcctggtca ccgtcccctc agcc
//
LOCUS       KCXD01007672             480 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:12833:4919
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007672
VERSION     KCXD01007672.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 480)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 480)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:12833:4919"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..478
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..478
     V_segment       124..403
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <397..>447
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66154.1"
                     /translation="CAIGPTGRWNGWSFDIW"
     D_segment       414..426
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       429..478
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        479..>480
                     /gene="IGHG"
BASE COUNT          108 a          146 c          138 g           88 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg cagcagctac aggcgcccac
      121 tctgaggtcc ttctggtgca gtctggggct gaggtgaagc agcctggggc ctcagtgaag
      181 gtctcctgca aggtttccgg atacaccctc accgaagtgt ccactcactg ggtgcgacag
      241 gcccccggaa aagggcttga gtgggtggga agtgttgatc ctgcatatgg tgaaatgaag
      301 gtccagggca gagtcaccat gaccgaggac acgtccacag acacagccta catggaactg
      361 agcagcctaa gatctgagga cacggccgtg tattactgtg cgattggccc taccggcagg
      421 tggaacggct ggtccttcga tatctggggc cctggcaccc caatcaccat ctcctcagcc
//
LOCUS       KCXD01007673             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2101:9769:10112
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007673
VERSION     KCXD01007673.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2101:9769:10112"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    101..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        101..468
     V_segment       101..394
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <386..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66155.1"
                     /translation="CARHSDPATTSWYFDLW"
     D_segment       407..414
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       418..468
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           90 a          148 c          126 g          106 t
ORIGIN      
        1 acatgggggc tctctgagag tcacggacat cctgtacaag aacatgcagt ttctgtggtt
       61 cttcctcctc ctggtggcag ctcccagatg ggtcctgtcc cagctgcagc tgcaggagtc
      121 gggcccagga ctggtgaagc cttcagagac cctgtccctc acctgcgctg tctctggtgg
      181 ctccatcagt cgtaactggt ggagttgggt ccgccagccc ccaggcaagg gactggagtg
      241 gattggacgt atctctggta gtcttggaag caccagttac aatccctccc tcgagagtcg
      301 agtcaccatt tcaagagaca cgtccaggaa ccagttctcc ctgaagctga cctctgtgac
      361 cgccgcggac acggccgtgt atttctgtgc gagacattca gaccccgcaa ctactagctg
      421 gtacttcgat ctctggggcc ctggcacccc aaatcaccat ctcctcagcc
//
LOCUS       KCXD01007674             463 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2109:19756:13077
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007674
VERSION     KCXD01007674.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 463)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 463)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2109:19756:13077"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    89..459
                     /note="immunoglobulin heavy chain variable region"
     V_region        89..459
     V_segment       89..382
                     /gene="IGHV3-127"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <374..>430
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66156.1"
                     /translation="CTRIGVGSLATAGDYFDHW"
     D_segment       405..412
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       414..459
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        460..>463
                     /gene="IGHG"
BASE COUNT           93 a          115 c          145 g          110 t
ORIGIN      
        1 acatggggat cagctctgaa cacagaggac catggagttg gggctgagct gggttttcct
       61 tgttgctatt ttaaaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggctt
      121 ggtccagcct ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttggtga
      181 ttatggcatg cactgggtcc gccaggctcc gggaaaggga ctggagtgga tctcatccat
      241 taggaacact ggtaaaatcg tatactacgc tgactccgtg aagggccgat tcaccatctc
      301 cagagacaac gccaagaact cgctgtctct gcgaatgagc agcctgagag ccgaggacac
      361 ggccgtgtat tactgtacta gaattggcgt cggatctctg gcaacggctg gtgactattt
      421 tgaccactgg ggccagggag tcctggtcac cgtctcctcc gcc
//
LOCUS       KCXD01007675             518 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10952:3778
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007675
VERSION     KCXD01007675.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10952:3778"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..516
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..516
     V_segment       144..434
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <429..>485
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66157.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       459..466
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       473..516
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        517..>518
                     /gene="IGHG"
BASE COUNT          111 a          134 c          158 g          115 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctatgttcag aggtgtccag tgtgaggtgc agctggtgga gtctggagga gacttggtcc
      181 agccgggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtagctatg
      241 gcatgacctg ggtccgccag gctccaggga aggggctgga gtgggtctca tacattagta
      301 ttggtggtag taatagatac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaga gaaaacgctc tccctgcaaa tgaacagcct gagacctgag gacacggccg
      421 tgtattactg tgcgtcgaac ctacgtggaa acacctacac ttactggcgg tcctttgact
      481 actggggcca gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007676             509 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14610:6380
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007676
VERSION     KCXD01007676.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14610:6380"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..507
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..507
     V_segment       144..437
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>476
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66158.1"
                     /translation="CARDRRVQSLSWFDVW"
     D_segment       447..453
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       463..507
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        508..>509
                     /gene="IGHG"
BASE COUNT          104 a          128 c          157 g          120 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccccagaatt cccaggtgtt tctgttcggc
       61 gatcagcact aaacacagaa cataccatgg agtttgtgct gagctgggtt tgccttgttg
      121 ctcttttgaa aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgcg caacctctgg attcagtttc agttactact
      241 acatgggctg ggtccgccag gctccaggga agggtctgga atggatctca ggtattaaca
      301 gtggtgggga taccacatac tatgcggact ccctgaaggg cagattcacc atctccagag
      361 acaacgccaa gaacacactg tctcttcaaa tggacggcct gagagctgag gactcggcag
      421 tctattactg tgcgcgagat cgacgtgtac agtcgttatc ctggttcgat gtctggggcc
      481 cgggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007677             513 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:12199:3799
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007677
VERSION     KCXD01007677.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:12199:3799"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..511
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..511
     V_segment       145..435
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <427..>480
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66159.1"
                     /translation="CARGVDNHHYSDTEFDLW"
     D_segment       457..463
                     /gene="IGHD2-13"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       477..511
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        512..>513
                     /gene="IGHG"
BASE COUNT          117 a          122 c          150 g          124 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctgggattc ccaggtgttt tcattcagag
       61 atcaggactg aacacacagg actcaccatg gagtttatgc tgagctgggt tttccttgtt
      121 gctatattaa aaggtgtcca gtgtgtggag cagctggtgg agtctggggg aggcttggta
      181 cagccggggg cgtccctgag actctcctgt gcagcctctg aattcacctt cagtagctat
      241 gacatgcact gggttcgcca ggctccaggg aagggtctgg agtggatatc aggtattaac
      301 attggcggtg acacatacta cccagactct gtgaagggtc ggttcaccat ctccagagac
      361 aatgccaaga actccttgta tcttcaaatg aacagcctga gagctgagga cactgctgta
      421 tattattgtg caagaggcgt agataaccac cactacagtg atacggagtt tgacctctgg
      481 ggccagggag tcctggtcac cgtctcctca gcc
//
LOCUS       KCXD01007678             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:11878:11185
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007678
VERSION     KCXD01007678.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:11878:11185"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66160.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           84 a          136 c          138 g          104 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgt
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt caccagggaa ggggctggag
      241 tggattgggt ttttcggtgg tagtggtggg aacacctact acaagtcgtc cctccagagt
      301 cgagtcacca tttcaaccga cacgtccaag aaccagttct ccctgacact gacctctgtg
      361 accgccgcgg acacggccct ctattactgt gcgaggggga atatagcagc gactggcatt
      421 gattactggg gccagggact cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007679             481 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1112:20310:1963
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007679
VERSION     KCXD01007679.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 481)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 481)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1112:20310:1963"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    125..479
                     /note="immunoglobulin heavy chain variable region"
     V_region        125..479
     V_segment       125..418
                     /gene="IGHV1-84"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <410..>448
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66161.1"
                     /translation="CVTVGPYHYFDYW"
     D_segment       419..424
                     /gene="IGHD5-27"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       434..479
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        480..>481
                     /gene="IGHG"
BASE COUNT          116 a          144 c          131 g           90 t
ORIGIN      
        1 acatggggag catcacacaa ccaccacatc cctcccctac agaagcccca gagcacagca
       61 cctcaccatg gactggacct ggaggctcct cctcttggtg gcagcagcta caggcgccca
      121 ctccgaggtc cagctggtac agtctggggc tgaggtgaag aagcctgggg cctccgtgaa
      181 aatctcctgc caggcttctg gatacacctt aaccgaccac tacctgcact gggtgcgaca
      241 ggctcctgga aaaggacttg agtggatggg gggtgttcat cctgaatatg ggaaagtaga
      301 ctacacacag aagttccaag acagagtcac catcaccgcg gacatgtcga cagagacagt
      361 ctacatggag ctgagcagcc tgagatctga ggacacggcc acttattact gtgtgacagt
      421 gggtccctac cattactttg actactgggg ccagggagcc ctggtcaccg tctcctcagc
      481 c
//
LOCUS       KCXD01007680             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:21865:10907
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007680
VERSION     KCXD01007680.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:21865:10907"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66162.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       450..455
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       462..506
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          108 a          122 c          155 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cccagaattc ccaggtgttt ctgttcggcg
       61 atcagcacta aacacagaac ataccatgga gtttgtgctg agctgggttt tccttgttgc
      121 tcttttgaaa ggtgtccagt gtgaggtgca gttggtggag tctgggggcg gcttggcaaa
      181 gcctgggggg tccctgagac tctcctgcgc agcctctgga ttcagcttca gtttctacta
      241 catgagttgg gtccgccagg ctccagggaa ggggctggag tggatctcag gtattaacgc
      301 tgatggggat agcacatact atgcagactc catgaagggc agattcacta tctccagaga
      361 gaacgccaag aacacactgc atcttcaaat ggacagcctg agagcagagg acacggctgt
      421 ctattactgt gtgagagatc gacgtgttca gtcgttatcc tggttcgatg tctggggccc
      481 gggagtcctg atcaccgtct cctcagcc
//
LOCUS       KCXD01007681             491 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:28553:14434
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007681
VERSION     KCXD01007681.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:28553:14434"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..489
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..489
     V_segment       123..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>458
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66163.1"
                     /translation="CASGFSIWLFYDVLDSW"
     D_segment       428..436
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       437..489
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        490..>491
                     /gene="IGHG"
BASE COUNT          115 a          124 c          148 g          104 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccccacag aagccccaga gcaaagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcggccact
      121 ctgaggtcca gttggtgcag tctggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacagtgtca ccgaattatc gattcactgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggag gtgttgatcc tgtaaaaggt gaagaaattc
      301 acggagagga gttccaggac agagtcacca tgaccgagga cccgtctaca gacacagcct
      361 acatggagtt gagcaacctg agatctgagg acacggccgt gtattattgt gcgagtgggt
      421 ttagtatctg gttattttac gacgttttgg attcctgggg ccaaggggtc gtcgtcaccg
      481 tctcctcagc c
//
LOCUS       KCXD01007682             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2103:18050:14171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007682
VERSION     KCXD01007682.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2103:18050:14171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66164.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       441..447
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          114 c          147 g          123 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccgg tgtgaggtgc aactggtgga atctggagga ggcttggttc
      181 aacctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaactttg
      241 gcatacactg ggtccgccag gctccaggga aggggctgga gtgggtggca gttatttcgt
      301 ctgatggaag taacaaatac tacgcaaact ctgtgaagag ccgattcagc atctccagag
      361 acaattccaa gaacatactt tatcttcaaa tgaacaactt gaaattggag gacacggccg
      421 tctattactg tgcgagagat gatattggga ccggttttga ctactggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007683             412 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2112:28556:8167
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007683
VERSION     KCXD01007683.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 412)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 412)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2112:28556:8167"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    56..410
                     /note="immunoglobulin heavy chain variable region"
     V_region        56..410
     V_segment       56..349
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <341..>379
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66165.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       355..360
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       364..410
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        411..>412
                     /gene="IGHG"
BASE COUNT           81 a           92 c          133 g          106 t
ORIGIN      
        1 acatgggggg ctgagctggg ttttccttgt tgctatttta agaggtgtcc agtgtgaggt
       61 gcagctggtg gagtctggag gaggtttggt tcagcctggg gggtccctga gactctcctg
      121 tgcagcctct ggattcacct tcagtatctc tggcatgcac tgggtccgcc aggctccagg
      181 gcaggggctg gattgggtgg cagttgaatc gtttgatgga ggtaagaaat actacgctga
      241 ctctgtgaag gaccgattca ccatctccag agacaattcc aagaacatgc tatatcttca
      301 aatgagcaac ctgaaattgg aggacacggc cgtgtattac tgtgtgagag atgcctacgg
      361 gggcggtttg gattcctggg gccaaggggt cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007684             467 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:7984:13506
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007684
VERSION     KCXD01007684.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 467)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 467)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:7984:13506"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..465
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..465
     V_segment       102..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <387..>434
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66166.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       399..406
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       421..465
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        466..>467
                     /gene="IGHG"
BASE COUNT           93 a          138 c          129 g          107 t
ORIGIN      
        1 acatgggggg ctctctgaga gtcatggacc tcctgtgcaa gaacatgaag cacctgtggt
       61 tcttccttct cctggtggca gttcccagat gggtcctgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgcgg ccttcggaga ccctgtccct cacctgcgct gtctctggtg
      181 actccatcag cagtagctac tggaactgga tccgccagcc cccagggaag ggactggagt
      241 ggattggata tatctctggt gcctatggga gcaccagcta caatccctcc ctcaagagtc
      301 gagtcaccat ttcaacagac acgtccaaga accacttttc cctgaggctg agttctgtga
      361 ccgccgcgga caccgccgtg tattactgtg tgagatatga ggatgaatcc attaactacc
      421 actttgacta ctggggccag ggagtcctgg tcaccgtctc ctcagcc
//
LOCUS       KCXD01007685             479 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:18505:15653
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007685
VERSION     KCXD01007685.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 479)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 479)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:18505:15653"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..477
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..477
     V_segment       123..402
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <396..>446
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66167.1"
                     /translation="CAIGPSGRWNHWSFEIW"
     D_segment       410..425
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       427..477
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        478..>479
                     /gene="IGHG"
BASE COUNT          106 a          136 c          141 g           96 t
ORIGIN      
        1 acatggggca tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagttaca ggcgcccact
      121 ctgaggtcct tctggtgcag tctggggctg aggtgatgca gcctggggcc tcagtgaagg
      181 tctcctgcaa ggtttccgga tacaccttca ccgatttgtc catacactgg gtgcgacagg
      241 cccctggaaa agggcttgag tgggtgggaa gtgttgatcc tgaatatggt gaaatgacgt
      301 tccaggggag agtcaccatg accgaggaca cgtctacaga cacggcctac atggagctga
      361 gtagcctgag atctgaggac acgggcgtgt attactgtgc gattggccct agcggcaggt
      421 ggaaccactg gtccttcgag atctggggac ctgggacccc aatcaccatc tcctcagcc
//
LOCUS       KCXD01007686             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:10999:15171
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007686
VERSION     KCXD01007686.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:10999:15171"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66168.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           98 a          139 c          127 g          106 t
ORIGIN      
        1 acatggggaa aagctctctg agagtcatgg acctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcagctccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc actgtctctg
      181 gcgactccat cagcagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ctacaacccc tccctcaaga
      301 gtcgagtctc catttccaca gacacgtcca agaaccagtt ttccctaagg ctgagttctg
      361 tgaccgccgc ggacaccgcc gtgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007687             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:10211:15181
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007687
VERSION     KCXD01007687.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:10211:15181"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66169.1"
                     /translation="CARVDCSGGVCYFDYW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          116 a          115 c          152 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtgggc tctggaggag acttggttca
      181 gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg
      241 catgcactgg gtccgccagg ctccagggaa ggggctggag tgggtggcaa ttatatcgta
      301 tgatggaaat gagaaatact acgcagactc tgtgaaggac cgattcacca tctccagaga
      361 caattccaag aacatgctat atcttcaaat aaacaacctg aaattggaag acacggcctt
      421 gtattactgt gcgagagtag actgtagtgg tggtgtctgc tactttgact attggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007688             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:9379:16741
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007688
VERSION     KCXD01007688.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:9379:16741"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66170.1"
                     /translation="CVRDAFGSGLDSW"
     D_segment       446..451
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          110 a          116 c          157 g          117 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggcgga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc ggaacctatg
      241 gcatgcactg ggtccgccag gctccaggga agggcctgga gtgggtgacg gttatatcga
      301 atgatggaag taagaaatac tacgcggact ctgtgaagga ccgattcagc atctccagag
      361 acaattccaa gaacatgcta tatcttcaaa tgaacaacgt gaaattggag gacacggccg
      421 tctattactg tgtgagagat gcgtttggta gcgggcttga ctcctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007689             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:8247:20881
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007689
VERSION     KCXD01007689.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:8247:20881"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66171.1"
                     /translation="CVRDAYGSGLDSW"
     D_segment       445..450
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          113 a          115 c          150 g          123 t
ORIGIN      
        1 acatgggggg gctctgggag aggagcccag ccctggaagt ccacagtgtt ccattcggtg
       61 atcagcacag agcacagagg actcaccatg aagtttgggc tgaactgggt tttccttgtt
      121 actattttaa gaggtgtcca gtgtgaggta caactggtgg agtctggagg aggcttggtt
      181 cagcctgggg gttccctgag actctcctgt gcagcctctg gattcacctt cagtactttt
      241 ggcatccact gggtccgcca ggctccaggg aaggggctgg agtgggtggc agttatatcg
      301 aatgatggaa gtaaaaaata ctacccagac tctgtgaagg accgattcac catctccaga
      361 gacaattccg aggccaatgt atatcttcaa atgaataacc tgaaattaga ggacacggcc
      421 gtgtattact gtgtgagaga tgcgtatggt tccggcttgg attcctgggg ccaaggggtc
      481 gtcgtcaccg tctcctcagc c
//
LOCUS       KCXD01007690             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2106:15883:18397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007690
VERSION     KCXD01007690.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2106:15883:18397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..491
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..491
     V_segment       126..419
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <411..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66172.1"
                     /translation="CAREYCTSDSCAGFLDSW"
     D_segment       420..431
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..491
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        492..>497
                     /gene="IGHG"
BASE COUNT          116 a          141 c          139 g          101 t
ORIGIN      
        1 acatgggggc atcacaaaac aaccacatcc ctcctctaaa gaagcccctg ggagcacagc
       61 tcatcaccat ggactggacc tggaggctcc tctttgtggt ggcagcagct acaggtgtcc
      121 agtcccaggt ccacttggtg cagtccgggg ctgaggtgaa gaagcctggg gcctcagtga
      181 aggtttcctg caaggcttct ggattcaccc tcgacaacta tggaatcaac tgggtgcgac
      241 aggcccctgg acaagggctt gagtggatgg gagtgatcat cccccttgtc ggtatagtga
      301 actacgtaga gagcctccag ggcagaggca cgataaccgc ggacacgtca acaaacacag
      361 tctacatgga actgaacagc ctgagatctg acgacacggc catctattac tgtgcgagag
      421 aatactgtac ttctgattct tgcgccggat tccttgactc ctggggccag ggagtcctgg
      481 tcaccgtctc cccagcc
//
LOCUS       KCXD01007691             514 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:11835:14634
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007691
VERSION     KCXD01007691.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 514)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 514)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:11835:14634"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    146..512
                     /note="immunoglobulin heavy chain variable region"
     V_region        146..512
     V_segment       146..431
                     /gene="IGHV3-100"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>481
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66173.1"
                     /translation="CVRGMDNYHYSNTDFDYW"
     D_segment       447..454
                     /gene="IGHD3-16"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       468..512
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        513..>514
                     /gene="IGHG"
BASE COUNT          119 a          120 c          145 g          130 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctgggatt cccaggtgtt ttcattcaga
       61 gatcaggact gaacacacag gactcaccat ggagtttatg ctgagctggg ttttccttgt
      121 ttctatatta aaaggtgtcc agtgtgtgga gcatctggtg gagtctgggg gagacttggt
      181 acagcctggg gcgtccctga gactctcctg tgcagcctct gaattcacct tcagtgccta
      241 tgacatgcac tgggttcgcc aggctccagg gaagggtcta gaatgggtat caggaattaa
      301 cattggcggt gacccatact acccagactc tgttaagggt cgattcacca tctccagaga
      361 caatgccaag aactccttgt atcttcagat gaacaatctg agagctgagg acactgctgt
      421 gtattattgt gtgaggggaa tggataacta ccactacagt aatacggact ttgactactg
      481 gggccaggga gtcctggtca ccgtctcctc agcc
//
LOCUS       KCXD01007692             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:15310:9284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007692
VERSION     KCXD01007692.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:15310:9284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66174.1"
                     /translation="CARDDSGTGFDYW"
     D_segment       436..444
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          113 a          110 c          154 g          117 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccacagt gttccattcg gtgatcagca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctatct
      121 taagaggtgt ccagtgtgaa gtgcaactgg tggagtctgg aggaggcttg gttcagcctg
      181 gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtaac tatggcatgc
      241 actgggtccg cctggctcca gggaaggggc tggagtgggt ggcagttatg tcgaatgatg
      301 gaattaataa gtactacgca gactctgtga aggaccgata caccatctcc agagacaatt
      361 cgaggaacat gctgtatctt caaatgaaca acctgaaatt ggaggacacg gccgtgtatt
      421 attgtgcgag agatgatagt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007693             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1113:15120:8000
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007693
VERSION     KCXD01007693.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1113:15120:8000"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    137..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        137..500
     V_segment       137..430
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <422..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66175.1"
                     /translation="CVRDRRVQSLSWFDVW"
     D_segment       444..449
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       456..500
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          106 a          122 c          154 g          120 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccccaga attcccaggt gtttctgttc ggcgatcagc
       61 actaaacaca gaacatacca tggagtttgt gctgagctgg gttttccttg ttgctctttt
      121 gaaaggtgtc cagtgtgagg tgcagttggt ggagtctggg ggcggcttgg caaagcctgg
      181 ggggtccctg agactctcct gcgcagcctc tggattcagc ttcagttact actacatgag
      241 ttgggtccgc caggctccag ggaaggggct ggagtggatc tcaggtattg ccgctgatgg
      301 ggatagcaca tactatgcag actccatgaa ggccagattc actatctcca gagagaacgc
      361 caagaacaca ctgcatcttc aaatggacag cctgagagca gaggacacgg ctgtctatta
      421 ctgtgtgaga gatcgacgtg ttcagtcgtt atcctggttc gatgtctggg gcccgggagt
      481 cctgatcacc gtctcctcag cc
//
LOCUS       KCXD01007694             431 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:20057:10958
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007694
VERSION     KCXD01007694.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 431)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 431)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:20057:10958"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    63..429
                     /note="immunoglobulin heavy chain variable region"
     V_region        63..429
     V_segment       63..356
                     /gene="IGHV3-177"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <348..>398
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66176.1"
                     /translation="CARVPGLVVFTASLDYW"
     D_segment       367..383
                     /gene="IGHD2-12"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       388..429
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        430..>431
                     /gene="IGHG"
BASE COUNT           91 a          100 c          133 g          107 t
ORIGIN      
        1 acatggggga gtttggcctg agctgggttt tccttgttgc tattttaaaa ggtgtccagg
       61 gtgaggtgca actggtggag tctgggggcg gcttggcaaa gcctgggggg tccctgagac
      121 tctcctgtgt agcctctgga ttcaccctca gtaactactg gatgtactgg gttcgccagg
      181 caccagggaa ggggctggag tggatctcag ctattaatag tgttggtgat agcacatact
      241 atgcagactc cgtgaagggc agattcacca tctccagaga gagcgccaag aacacactat
      301 atcttcaaat ggacagcctg agagctgagg acacggctgt ctattactgt gcgagagtac
      361 cgggcctagt ggtatttact gcttcacttg actactgggg ccagggagtc ctggtcaccg
      421 tctcctcagc c
//
LOCUS       KCXD01007695             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:20282:4825
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007695
VERSION     KCXD01007695.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:20282:4825"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    141..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        141..495
     V_segment       141..434
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <426..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66177.1"
                     /translation="CVRDAYGAGLDVW"
     D_segment       438..443
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..495
                     /gene="IGHJ5-5"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          109 a          107 c          162 g          119 t
ORIGIN      
        1 acatggggtc tgggagagga gcccagccct ggaagtccac agtgttccat tcggtgatca
       61 gcacagaaca cagaggactc accatgaagt ttgggctgag ctgggttttc cttgttgcta
      121 ttttaggagg tgtccagtgt gaggtgcagc tggtggagtc tggaggaggc ttgggtcagc
      181 cgggggggtc cctgagactc tcctgtgtag cctctggatt caccttcagt acctttggca
      241 tgcactgggt ccgccaggct ccagggaagg ggctggagtg ggtggcagtt ttatcgaatg
      301 atggaagtaa gaaatactac ggagaccctg tgaaggaccg atttatcatc tccagagaca
      361 atgccaagaa cactgtctat cttcaagtga ataatctgaa aatggaagac acggccgtgt
      421 attactgtgt gagagacgca tatggggcgg gattggatgt ctggggccgg ggagttctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007696             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1107:25025:11397
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007696
VERSION     KCXD01007696.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1107:25025:11397"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    87..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        87..468
     V_segment       87..380
                     /gene="IGHV4-174"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <372..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66178.1"
                     /translation="CARRPTRTRVLYEATGEDFDSW"
     D_segment       385..389
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT           94 a          143 c          130 g          103 t
ORIGIN      
        1 acatgggcac agacatcctg tgcaagaaca tgaagcacct gtggttcttc ctcctcctgg
       61 tggcagctcc cagatgggtc ctgtcccagg tgcagctgca ggagtcgggc ccaggactgg
      121 tgaagccttc ggagaccctg tccctcacct gcgctgtctc tggtggctcc ttcagcactt
      181 cctactggag ctggatccgc caggccccag ggaagggact ggagtggatt ggatatatct
      241 atgctgatag tgggaccacc agctacaacc cgtccctcaa gagtcgagtc accatttcaa
      301 tagacacgtc caagaatctg tactccctga aactgagctc tgtgaccgcc gcggacacgg
      361 ccttttatta ctgtgcgaga cgtcctactc gcacgcgggt tctatatgag gcgacagggg
      421 aagactttga ctcctggggc cagggactcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007697             482 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:25911:9486
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007697
VERSION     KCXD01007697.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:25911:9486"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    126..480
                     /note="immunoglobulin heavy chain variable region"
     V_region        126..480
     V_segment       126..405
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <399..>449
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66179.1"
                     /translation="CAIGPSGNWNGWSFDIW"
     D_segment       413..428
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       431..480
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        481..>482
                     /gene="IGHG"
BASE COUNT          106 a          140 c          140 g           96 t
ORIGIN      
        1 acatggggga gcatccaaca acaaccacat ccctccccta cagaagcccc agagcacagc
       61 acctcaccat ggactggacc tggaggatcc tcctcttggt ggcagcagct acaggcgccc
      121 actctgaggt ccttctggtg cagtctgggg ctgaggtgat gcagcctggg gcctcagtga
      181 aggtctcctg caaggtttcc ggatacacct tcaccgaatt gtccatgcac tgggtgcgac
      241 aggcccctgg aaaagggctt gagtgggtgg gaagtgttga tcctgcatat ggtgaaatgg
      301 tgttccaggg cagagtcacc atgaccgagg acacgtctat agacacagcc tacatggagt
      361 tgagcagcct gagatctgag gacacggccg tgtattactg cgcgattggc cctagcggca
      421 actggaacgg ctggtccttc gatatctggg gacctggcac cccaatcacc atctcctcag
      481 cc
//
LOCUS       KCXD01007698             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:18208:19762
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007698
VERSION     KCXD01007698.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:18208:19762"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66180.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           96 a          134 c          129 g          110 t
ORIGIN      
        1 acatggggga tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga
      121 gtcgggccca ggactggtga agtcttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tgactccatc agcaatagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007699             329 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:16166:5224
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007699
VERSION     KCXD01007699.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 329)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 329)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:16166:5224"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    1..327
                     /note="immunoglobulin heavy chain variable region"
     V_region        1..327
     V_segment       1..269
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <261..>296
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66181.1"
                     /translation="CARWSAANFDYW"
     D_segment       274..280
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       283..327
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        328..>329
                     /gene="IGHG"
BASE COUNT           69 a           94 c           96 g           70 t
ORIGIN      
        1 gactggtgaa gccttcggag accctgtccc tcacctgcga tgtctctggg ggctccatca
       61 gcagtggtta tggctggagc tggatccgcc agcccccagg gaaggggctg gagtggattg
      121 ggtgtatcta cgatagtagt ggaaacacct actacaaccc ctccctcaag agtcgagtca
      181 ccatttcaaa agacacgtcc aagaaccagt tctccctgaa gatgaggtct atgaccgccg
      241 cggacgcggc cgtgtattat tgtgcgagat ggtcggcagc caactttgac tactggggcc
      301 agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007700             356 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18710:10284
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007700
VERSION     KCXD01007700.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 356)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 356)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18710:10284"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    4..354
                     /note="immunoglobulin heavy chain variable region"
     V_region        4..354
     V_segment       4..286
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <279..>323
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66182.1"
                     /translation="CARSTGSYRGYFDYW"
     D_segment       293..303
                     /gene="IGHD1-8"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       309..354
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        355..>356
                     /gene="IGHG"
BASE COUNT           74 a           92 c          116 g           74 t
ORIGIN      
        1 acatggggga gtctgggggc ggcttggcgc agcctggggg gtccctgaaa ctcccctgcg
       61 cagcctctgg attcagcttc agctacttct acatgagctg ggtccgccag gctccaggaa
      121 aggggctgga gtggatctca gggattgaca gtggtggggg tgacacattc tatgcagact
      181 ccgtgaaggg cagattcacc atctccagag agaacgccaa gaggacactg tatcttcaaa
      241 tggacagcct gagacctgag gacacggctg tctattactg tgcgaggtct actgggagct
      301 acaggggata ctttgactac tggggccagg gagtcctggt caccgtctcc tcagcc
//
LOCUS       KCXD01007701             476 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:3638:13187
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007701
VERSION     KCXD01007701.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 476)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 476)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:3638:13187"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..474
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..474
     V_segment       123..397
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <393..>443
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66183.1"
                     /translation="CAVGNSGSWISWSFDVW"
     D_segment       406..420
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       425..474
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        475..>476
                     /gene="IGHG"
BASE COUNT          115 a          134 c          135 g           92 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcagagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctgatgcag tccggggctg aggtgaagaa gcctggggcc tcagtgaagg
      181 tctcctgcaa ggttaccgga tacaccttca ccgaattatc catgcactgg gtgcgacagg
      241 cccctggaaa aggacttgag tggatgggaa gtgttgatcc tgtatatggt gaaatgaaag
      301 agggcagagt caccatgacc gaggacacgt ctacagacac agcctacatg gaactgagta
      361 gcctgagatc tgaggatacg gccgtgtatt attgtgcagt cggcaatagc ggcagctgga
      421 tctcctggtc cttcgatgtc tggggccctg gcaccccaat caccatctcc tcagcc
//
LOCUS       KCXD01007702             506 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:14379:9280
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007702
VERSION     KCXD01007702.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 506)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 506)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:14379:9280"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..504
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..504
     V_segment       144..432
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <426..>473
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66184.1"
                     /translation="CARGETASVYYGLDSW"
     D_segment       441..452
                     /gene="IGHD5-28"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       453..504
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        505..>506
                     /gene="IGHG"
BASE COUNT          105 a          130 c          159 g          112 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc actggaagtc cacagtgttc cattcggtga
       61 tcagcactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc aactggtgga gtctgggggc ggcttggcaa
      181 agcctggggg atccctgaga ctctcctgtg cagcctctgg attcaccttc aatacctatg
      241 ctatacactg ggtccgccag gctcccggga aggggctgga ctgggtctca gccattagta
      301 gtggtgggcg cacatactac gcagactccg tgaagggccg agtcaccatc tccagagaca
      361 actcaaagaa cacggtctcc ctgcaaatga acagcctggg agctgaggac acggccgtgt
      421 tttactgtgc gagaggggag acagcttcag tttactacgg tttggattcc tggggccaag
      481 gggtcgtcgt caccgtctcc tcagcc
//
LOCUS       KCXD01007703             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:16683:14305
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007703
VERSION     KCXD01007703.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:16683:14305"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66185.1"
                     /translation="CASGPSGSWNDWYFDIW"
     D_segment       421..436
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          143 c          135 g           95 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccattc
      121 tgaggtccag ctggtgcaat ctggggctga ggtgatgcag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acaccttcac cgaattatcc atacactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggaag tgttgatcct ttatatggtg aaatgataca
      301 cacagaacag ttccagggca gagtcaccct gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cgagtggccc
      421 tagcggcagc tggaacgact ggtacttcga tatctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007704             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2115:16216:4245
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007704
VERSION     KCXD01007704.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2115:16216:4245"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66186.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       441..453
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          109 a          116 c          153 g          122 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggttc atctggtgga gtctggagga gacttggttc
      181 agcctggggg gtccctgaga ctctcctgtg cagtctctgg attcaccttc agtagctttg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga gtgggtggca gtgacgtcct
      301 atgatggaag ttggaagtac tacggagact ctgtgaagga ccgattcacc atctccagag
      361 acaattccaa gagcctgcta tatcttcaaa tgaacaacct gaacttggag gacacggccg
      421 tttattactg tgcgagaggg gaatacagta actctattga cttctggggc cagggagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007705             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1118:18504:14545
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007705
VERSION     KCXD01007705.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1118:18504:14545"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66187.1"
                     /translation="CASGFSVWLFNDVLDSW"
     D_segment       427..435
                     /gene="IGHD3-41"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       445..488
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          114 a          123 c          148 g          105 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcggccactc
      121 tgaggtccag ttggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acagtgtcac cgaattatcg attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg tgttgatcct gtaaaaggtg aagaaattca
      301 cggagaggag ttccaggaca gagtcaccat gaccgaggac ccgtctacag acacagccta
      361 catggagttg agcaacctga gatctgagga cacggccgtg tattattgtg cgagtgggtt
      421 tagtgtctgg ttatttaacg acgttttgga ttcctggggc caaggggtcg tcgtcaccgt
      481 ctcctcagcc
//
LOCUS       KCXD01007706             380 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:17413:2578
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007706
VERSION     KCXD01007706.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 380)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 380)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:17413:2578"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    18..378
                     /note="immunoglobulin heavy chain variable region"
     V_region        18..378
     V_segment       18..311
                     /gene="IGHV3-94"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <303..>347
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66188.1"
                     /translation="CARVVGGAAGYFDFW"
     D_segment       312..316
                     /gene="IGHD2-11"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       332..378
                     /gene="IGHJ1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        379..>380
                     /gene="IGHG"
BASE COUNT           81 a           97 c          124 g           78 t
ORIGIN      
        1 acatgggggc ccagtgcgag gtgcagctgg tggagtctgg gggcggcttg gcaaagcctg
       61 gggggtccct gagactctcc tgcgcagcct ctggattcaa cttcaattac tactacatga
      121 actgggtccg ccaggctcca gggaaggggc tggaatggat ctcaggtatt aacagtggtg
      181 gggatagcac atactatgcg gactccgtga agggcagatt caccatctcc agagagaacg
      241 ccaagaacac actgtatctt caaatggaca gcctgagagc tgaggacacg gctgtctatt
      301 actgtgcgag agtggtgggt ggtgccgcag gatacttcga cttctggggc cagggcgccc
      361 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007707             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2105:20183:12218
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007707
VERSION     KCXD01007707.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2105:20183:12218"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..411
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66189.1"
                     /translation="CAAGHSGTWIHCYFDLW"
     D_segment       427..434
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       438..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          146 c          134 g           93 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag catagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagcaacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaag gtttccggat acatcttcac cgaattatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttgagt ggatgggagg cgttgatcct gcatatggtg aatttacacc
      301 cggagagaag ttccagggca gagtaacaat gaccgaggac acgtctatag acacagccta
      361 catggaactg agcagcctga actctgagga cacggccgtc tattactgtg cagccgggca
      421 cagcggcacc tggatccact gctacttcga tctctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007708             511 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2114:11669:15703
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007708
VERSION     KCXD01007708.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2114:11669:15703"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    128..509
                     /note="immunoglobulin heavy chain variable region"
     V_region        128..509
     V_segment       128..421
                     /gene="IGHV1-138"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <413..>478
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66190.1"
                     /translation="CARVLYYDSGYSTNPYNRFDVW"
     D_segment       428..446
                     /gene="IGHD3-18"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..509
                     /gene="IGHJ5-4"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        510..>511
                     /gene="IGHG"
BASE COUNT          117 a          145 c          142 g          107 t
ORIGIN      
        1 acatggggga gcatcacata acaaccacgt ccctcctcta aagaagcccc tgggaacaca
       61 gctcatcacc atggacttga cctggaggct cctctttgtg gtggcagcag ctacaggtga
      121 ccagtcccag gtccagctgg tgcagtccgg ggctgaggtg aagaagcctg gggcctcagt
      181 gaagctctcc tgcaaggctt ctggatacac cttcaccatc tatgccatca cttgggtgcg
      241 acaggcccct ggacaagggc ttgagtggat gggaggaatc atccctcttg ttggcataac
      301 aaacgacgca cagaagttcc agggcagagt cacgcttacc gcggacacgt ccacaagcac
      361 agcctacatg gagctgagca gcctgagatc tgaggacacg gccgtgtatt attgtgcgag
      421 agttttatac tatgatagtg gttattccac gaacccctac aaccggttcg atgtctgggg
      481 tccgggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007709             469 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:19243:19485
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007709
VERSION     KCXD01007709.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 469)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 469)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:19243:19485"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    104..467
                     /note="immunoglobulin heavy chain variable region"
     V_region        104..467
     V_segment       104..397
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <389..>436
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66191.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       401..408
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       423..467
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        468..>469
                     /gene="IGHG"
BASE COUNT           97 a          134 c          129 g          109 t
ORIGIN      
        1 acagggggaa tgctctctga gagtcatgga cctcctgtgc aagaacatga agcacctgtg
       61 gttcttcctt ctcctggtgg cagctcccag atgggtcctg tcccaggtgc acctgcagga
      121 gtcgggccca ggactggtga agtcttcgga gaccctgtcc ctcacctgcg gtgtctctgg
      181 tgactccatc agcaatagct actggaactg gatccgccag cccccaggga agggactgga
      241 gtggattggg tatatctctg gtgcttatgg gagcaccagc tacaatccct ccctcaagag
      301 tcgagtcacc atttcaacag acacgtccaa gaaccagttt tccctgaggc tgagttctgt
      361 gaccgccgcg gacaccgccg tgtattattg tgtgagatat gaggatgaat ccattaacta
      421 ccactttgac tactggggcc agggagtcct ggtcaccgtc tcctcagcc
//
LOCUS       KCXD01007710             455 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2119:22345:12586
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007710
VERSION     KCXD01007710.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 455)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 455)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2119:22345:12586"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    102..453
                     /note="immunoglobulin heavy chain variable region"
     V_region        102..453
     V_segment       102..398
                     /gene="IGHV4-72"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>422
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66192.1"
                     /translation="CARWGTPFDFW"
     D_segment       399..403
                     /gene="IGHD3-17"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       410..453
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        454..>455
                     /gene="IGHG"
BASE COUNT           84 a          136 c          133 g          102 t
ORIGIN      
        1 acatgggggg ttctctgaga gtcacggacc tcctgggcaa gaacatgaag catctgtggt
       61 tcttcctcct cctggtggca gctcccagat gggtcttgtc ccaggtgcag ctgcaggagt
      121 cgggcccagg actggtgagg ccttcggaga ccctgtccct cacctgcgct gtctctggta
      181 gctccatcaa cagtggttat gcctggagtt ggatccgcca gcccccaggg aaggggctgg
      241 agtgggttgg gcatttctat gatagtagtg ggaacaccta ctacaacccc tccctcaaga
      301 gtcgagtcac catttcaaag gacacgtcca agaaccaatt ctccctgaag ctgacctctg
      361 tgaccgccgc ggacacggcc gtctatttct gtgcgagatg ggggaccccc tttgacttct
      421 ggggccaggg agtcctggtc accgtctcct cagcc
//
LOCUS       KCXD01007711             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:10914:11670
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007711
VERSION     KCXD01007711.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:10914:11670"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..495
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..495
     V_segment       144..436
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>464
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66193.1"
                     /translation="CANALTGGLDYW"
     D_segment       442..450
                     /gene="IGHD7-40"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       454..495
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        496..>497
                     /gene="IGHG"
BASE COUNT          104 a          127 c          158 g          108 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcaccactga acacagagga ctcaccatgg agtctgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctgggggc ggcttggcaa
      181 agcctggggg gtccctgaga ctctcctgtg cagcctctgg attcaccttc agtaggtact
      241 ggatgaactg ggtccgccag gctccaggga aggggctgga gtgggtctca gctattacta
      301 gtggtgggga tagcacgtac tacgcagact ccgtgaaggg ccgattcacc atctccagag
      361 acaactcaaa aaacacgctc tccctgcaaa tgaacagcct tagagcggag gacacggccg
      421 tgtattactg tgccaacgca ttaactgggg ggcttgacta ctggggccag ggagtcctgg
      481 tcaccgtctc ctcagcc
//
LOCUS       KCXD01007712             501 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2118:16848:20763
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007712
VERSION     KCXD01007712.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2118:16848:20763"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    145..499
                     /note="immunoglobulin heavy chain variable region"
     V_region        145..499
     V_segment       145..438
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <430..>468
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66194.1"
                     /translation="CVRDVRGTGFDFW"
     D_segment       448..453
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       457..499
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        500..>501
                     /gene="IGHG"
BASE COUNT          115 a          113 c          156 g          117 t
ORIGIN      
        1 acatggggga gctctgggag aggagcccag ccctggaagt ccacagtgtt ccaatcggtg
       61 atcagcacag aacacagagg actcaccatg aagtttgggc tgagctgggt tttccttgtt
      121 gctattttaa gaggtgtcca gtgtgaggtg cagctggtgg agtctggagg aggcttggtt
      181 cagccggggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagttcctat
      241 ggcatacact gggtccgcca gtctccaggg aaggggctgg agtgggtggc agttatatcg
      301 tatgatgaaa ctaagaagta ctacgcagac tctgtgaggg accgattcac catctccaga
      361 gacaattcca aaaacatggt atatcttcaa atgaacaacc tgaaattgga ggacacggcc
      421 gtatattact gtgtgagaga tgtcagggga acggggtttg acttctgggg ccagggaggc
      481 ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007713             318 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2110:14088:18973
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007713
VERSION     KCXD01007713.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 318)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 318)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2110:14088:18973"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    5..316
                     /note="immunoglobulin heavy chain variable region"
     V_region        5..316
     V_segment       5..255
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <247..>285
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66195.1"
                     /translation="CARGEYSNSIDFW"
     D_segment       259..271
                     /gene="IGHD4-23"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       275..316
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        317..>318
                     /gene="IGHG"
BASE COUNT           78 a           79 c           84 g           77 t
ORIGIN      
        1 acatgggggt ccctgagact ctcctgtaca gcctctggat tcaccttcag tcactatggc
       61 atgcactggg tccgccaggc tccagggaag gggctggatt gggtggcagt tatgtcgttt
      121 gatgaaaatg tgaaattcta cgcagactct gtgaaggacc gattcaccat ctccagagac
      181 aattccaaga acatgctata tcttcaaatg aacaacctga aattggagga cacggccctg
      241 tattactgtg cgagagggga atacagtaac tctattgact tctggggcca gggagtcctg
      301 gtcaccgtct cctcagcc
//
LOCUS       KCXD01007714             508 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1104:11420:11319
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007714
VERSION     KCXD01007714.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 508)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 508)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1104:11420:11319"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    143..506
                     /note="immunoglobulin heavy chain variable region"
     V_region        143..506
     V_segment       143..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <428..>475
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66196.1"
                     /translation="STRVDCSGGVCYFDHW"
     D_segment       443..463
                     /gene="IGHD2-14"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       464..506
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        507..>508
                     /gene="IGHG"
BASE COUNT          115 a          113 c          155 g          125 t
ORIGIN      
        1 acatgggggc tctgggagag gagcccagcc ctggaagtcc acagtgttcc attcggtgat
       61 cagcacagaa cacagaggac tcaccatgaa gtttgggctg agctgggttt tccttgttgc
      121 tattttaaga ggtgtccagt gtgaggtgca gctggtggag tctggaggag gcttggttca
      181 gcctgggggg tccctgagac tctcctgtgt agcctctgga ttcaccttca gtagctatgg
      241 cataaactgg gtccgccagg ctccagggaa ggggctggag tgggtgggaa ttgtttcgtt
      301 tgatggaact aagagatact acgcagactc tgtgagggac cgattcacca tctccagaga
      361 caattccaag aatatgctat atcttcaaat gaacaacctg aaaatcgaag acacggccgt
      421 gtattatagt acgagagtag actgtagtgg tggtgtctgc tactttgacc actggggcca
      481 gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007715             494 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2116:6957:13844
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007715
VERSION     KCXD01007715.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 494)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 494)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2116:6957:13844"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    138..492
                     /note="immunoglobulin heavy chain variable region"
     V_region        138..492
     V_segment       138..431
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <423..>461
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66197.1"
                     /translation="CARDDIGTGFDYW"
     D_segment       435..441
                     /gene="IGHD2-9"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..492
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        493..>494
                     /gene="IGHG"
BASE COUNT          116 a          110 c          146 g          122 t
ORIGIN      
        1 acatgggggg gagaggagcc cagccctgga agtccatagt gttccattcg gtgatcaaca
       61 cagaacacag aggactcacc atgaagtttg ggctgagctg ggttttcctt gttgctattt
      121 taagaggtgt ccggtgtgag gtgcaactgg tggagtctgg aggaggcttg gttcaacctg
      181 gggggtccct gagactctcc tgtgaagcct ctggattcac cttcagtaag tttggcatac
      241 actgggtccg ccaggctcca gggaaggggc tggagtgggt ggcagttatt tcgtctgatg
      301 gaagtaacaa atactacgca aactctgtga agagccgatt caccatctcc agagacaatt
      361 ccaagaacat actttatctt caaatgaaca acttgaaatt ggaggacacg gccgtctatt
      421 actgtgcgag agatgatatt gggaccggtt ttgactactg gggccaggga gtcctggtca
      481 ccgtctcctc agcc
//
LOCUS       KCXD01007716             468 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2107:13082:14664
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007716
VERSION     KCXD01007716.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 468)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 468)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2107:13082:14664"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    112..466
                     /note="immunoglobulin heavy chain variable region"
     V_region        112..466
     V_segment       112..391
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <385..>435
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66198.1"
                     /translation="CATGPTGTWNAWYLDIW"
     D_segment       405..415
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       417..466
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        467..>468
                     /gene="IGHG"
BASE COUNT          103 a          142 c          132 g           91 t
ORIGIN      
        1 acatgggcaa ccacatccct cccctacaga agccccagag cacagcacct caccatggac
       61 tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc tgaagtccag
      121 ctggtgcagt ctggggctga ggtgaagaag cctggggcct cagtgagggt ctcctgcagg
      181 atttccggat acaccttcac cgaattatcc atacactggg tgcggcaggc ccctggaaaa
      241 gggcttgagt ggatgggaag tgttgatcct ctgtatggtg aaatgaagtt ccagggcaga
      301 gtcaccatga ccgaggacac gtctacagac acagcctact tggaactgag cggcctgact
      361 tctgaggaca cggccgtgta ttactgtgcg actggcccta ccggcacctg gaacgcctgg
      421 tacctcgata tctggggccc tggcacccca atcaccatct cctcagcc
//
LOCUS       KCXD01007717             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:17923:12859
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007717
VERSION     KCXD01007717.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:17923:12859"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    94..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        94..460
     V_segment       94..387
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <379..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66199.1"
                     /translation="CARYDDDDYGSYYLDYW"
     D_segment       397..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           89 a          139 c          127 g          107 t
ORIGIN      
        1 acatggggga gagtcatgga cctcctgtgc aagaacatga agcacctgtg gttcttcctt
       61 ctcctggtgg cagctcccag atgggtcctg tcccaggtgc agctgcagga gtcgggccca
      121 ggactggtga agccttcgga gaccctgtcc ctcacctgcg ctgtctctgc tgactccatc
      181 accagtagct tctggaactg gatccgccag cccccaggga gggggctgga gtggattggc
      241 tatatctctg gtgctactgg gagttccagc tacaacccct ccctcaagag tcgagtctcc
      301 atttcaacag acacgtccaa gaaccagttt tccctgaagc tgaactctgt gaccgccgcg
      361 gacaccgccg tgtattactg tgcgagatat gacgacgatg attacggttc ttattacctt
      421 gactactggg gccagggagt cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007718             470 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1105:10460:11277
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007718
VERSION     KCXD01007718.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 470)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 470)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1105:10460:11277"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    105..468
                     /note="immunoglobulin heavy chain variable region"
     V_region        105..468
     V_segment       105..398
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <390..>437
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66200.1"
                     /translation="CVRYEDESINYHFDYW"
     D_segment       402..409
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       424..468
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        469..>470
                     /gene="IGHG"
BASE COUNT          100 a          137 c          125 g          108 t
ORIGIN      
        1 acatggggaa atgctctctg agagtcatgg ccctcctgtg caagaacatg aagcacctgt
       61 ggttcttcct tctcctggtg gcaactccca gatgggtcct gtcccaggtg cagctgcagg
      121 agtcgggccc aggactggtg aagccttcgg agaccctgtc cctcacctgc gctgtctctg
      181 gtgactccat cagcagtagc tactggaact ggatccgcca gcccccaggg aagggactgg
      241 agtggattgg gtatatctct ggtgcttatg ggagcaccag ttacaacccc tccctcaaaa
      301 gtcgagtcac catttcaaca gacacgtcca agaaccaatt ttccctgagg ctgagttctg
      361 tgaccgccgc ggacaccgcc atgtattact gtgtgagata tgaggatgaa tccattaact
      421 accactttga ctactggggc cagggagtcc tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007719             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1110:20857:9948
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007719
VERSION     KCXD01007719.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1110:20857:9948"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..436
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66201.1"
                     /translation="CARDDNGVLIDFW"
     D_segment       437..443
                     /gene="IGHD3-15"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       459..498
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          116 a          115 c          149 g          120 t
ORIGIN      
        1 acatggggag ctctgggaga ggaacccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttattg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agcctggggg gtccctgaga ctctcctgta cagcctctgg attcaccttc agtagctatg
      241 gcttgcactg ggtccgccag gctccaggga aggggctgga gtgggtgaca gttatatcgt
      301 ctgatgaaga taggaaatac tacgcagact ctctgaagga ccgattcacc atttccagag
      361 acaattccaa gaacacgcta tatcttcaaa tgaacaacct gaaattggag gacacggccg
      421 tgtattactg tgcgagggat gataatgggg tgcttatcga cttctggggc caggaagtcc
      481 tggtcaccgt ctcctcagcc
//
LOCUS       KCXD01007720             500 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2102:6344:11020
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007720
VERSION     KCXD01007720.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 500)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 500)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2102:6344:11020"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    144..498
                     /note="immunoglobulin heavy chain variable region"
     V_region        144..498
     V_segment       144..437
                     /gene="IGHV3-50"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <429..>467
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66202.1"
                     /translation="CVRDAYGGGLDSW"
     D_segment       443..448
                     /gene="IGHD4-24"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       452..498
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        499..>500
                     /gene="IGHG"
BASE COUNT          107 a          117 c          158 g          118 t
ORIGIN      
        1 acatggggag ctctgggaga ggagcccagc cctggaagtc cacagtgttc cattcggtga
       61 tcagcacaga acacagagga ctcaccatga agtttgggct gagctgggtt ttccttgttg
      121 ctattttaag aggtgtccag tgtgaggtgc agctggtgga gtctggagga ggcttggttc
      181 agccgggagg gtccctgaga ctctcctgtg cagcctctgg attcagcttc agtatctctg
      241 gcatgcactg ggtccgccag gctccaggga aggggctgga atgggtggca gttgaatcgt
      301 ttgatggaac taagaaattc tacgcagact ctgtgaagga ccgattcacc atctccagag
      361 acagttccag gaacatgctg tatcttcaaa tgaacaacct gaaactggag gacacggccg
      421 tctattactg tgtgagagat gcctacgggg gcggtttgga ttcctggggc caaggggtcg
      481 tcgtcaccgt ctcctcagcc
//
LOCUS       KCXD01007721             502 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2104:9882:11189
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007721
VERSION     KCXD01007721.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 502)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 502)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2104:9882:11189"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..500
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..500
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>469
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66203.1"
                     /translation="CATHGGYRGIWNSLYYGFDSW"
     D_segment       422..442
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       449..500
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        501..>502
                     /gene="IGHG"
BASE COUNT          119 a          145 c          141 g           97 t
ORIGIN      
        1 acatggggat cacacaacaa ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctacag gcgcccactc
      121 tgaggtccag ctggtgcagt ctggggctga agtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcaaa gtttccggat acaccttcac cgatttatcc attcactggg tgcgacaggc
      241 ccctggaaaa gggcttcagt ggatgggagg tgttgatcct ggacatagtg aaatgataca
      301 cgcagacaac ttccagggca gagtcgccat gaccgaggac acgtctacag acacagccta
      361 catggagctg agcagcctga gatctgagga cacggccgtg tattactgtg cgacccacgg
      421 agggtataga ggcatctgga actccctata ctacggtttc gattcctggg gccaaggggt
      481 cgtcgtcacc gtctcctcag cc
//
LOCUS       KCXD01007722             503 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:19887:4957
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007722
VERSION     KCXD01007722.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2113:19887:4957"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    123..501
                     /note="immunoglobulin heavy chain variable region"
     V_region        123..501
     V_segment       123..414
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <408..>470
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66204.1"
                     /translation="CATHGGYSDIWNSLYYGLDSW"
     D_segment       437..444
                     /gene="IGHD1-1"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       450..501
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        502..>503
                     /gene="IGHG"
BASE COUNT          120 a          141 c          140 g          102 t
ORIGIN      
        1 acatggggga tcacacaaca accacatccc tcccctacag aagccccaga gcacagcacc
       61 tcaccatgga ctggacctgg aggatcctcc tcttggtggc agcagctaca ggcgcccact
      121 ctgaggtcca gctggtgcag tctggggctg aggttaagaa gcctggggcc tcagtgaggg
      181 tctcctgcca ggtttccgga tacaccttca ccgaattatc catgcagtgg gtgcgacagg
      241 cccctggaaa agggcttgag tggatgggat gtgttgatcc tgtaaatggt gaaataatac
      301 acgcagacaa cttccagggc agagtcacca tgaccgaaga cacgtctata gacacagcct
      361 acatggaact gagcagcctg agatctgagg atacggccgt atattactgt gcgacccacg
      421 gaggctatag tgacatctgg aactccctgt actacggttt ggattcctgg ggccaagggg
      481 tcttcgtcac cgtctcctca gcc
//
LOCUS       KCXD01007723             451 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1106:13899:2693
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007723
VERSION     KCXD01007723.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 451)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 451)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1106:13899:2693"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    77..449
                     /note="immunoglobulin heavy chain variable region"
     V_region        77..449
     V_segment       77..367
                     /gene="IGHV3-76"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="02"
     CDS             <362..>418
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66205.1"
                     /translation="CASNLRGNTYTYWRSFDYW"
     D_segment       392..399
                     /gene="IGHD2-10"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       406..449
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        450..>451
                     /gene="IGHG"
BASE COUNT           94 a          112 c          138 g          107 t
ORIGIN      
        1 acatggggga gagaaacagt ggatctgtgt ggtagtttct gaccttggtg tctctctgtt
       61 tgcaggtgtc cagtgtgagg tgcagctggt ggagtctgga ggagacttgg tccagccggg
      121 ggggtccctg agactctcct gtgcagcctc tggattcacc ttcagtagtt atggcatgac
      181 ctgggtccgc caggctccag ggaaggggct ggagtgggtc tcatacatta gtattggtgg
      241 tagtaataga tactacgcag actccgtgaa gggccgattc accatctcca gagacaactc
      301 agagaaaacg ctctccctgc aaatgaacag cctgagacct gaggacacgg ccgtgtatta
      361 ctgtgcgtcg aacctacgtg gaaacaccta cacttactgg cggtcctttg actactgggg
      421 ccagggagtc ctggtcaccg tctcctcagc c
//
LOCUS       KCXD01007724             490 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2117:12604:8045
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007724
VERSION     KCXD01007724.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 490)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 490)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:2117:12604:8045"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    122..488
                     /note="immunoglobulin heavy chain variable region"
     V_region        122..488
     V_segment       122..413
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <407..>457
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66206.1"
                     /translation="CATSPSGTWLYWYFDFW"
     D_segment       427..433
                     /gene="IGHD1-7"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       440..488
                     /gene="IGHJ2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        489..>490
                     /gene="IGHG"
BASE COUNT          117 a          143 c          135 g           95 t
ORIGIN      
        1 acagggggat cacacaacag ccacatccct cccctacaga agccccagag cacagcacct
       61 caccatggac tggacctgga ggatcctcct cttggtggca gcagctgcag gcgcccgctc
      121 tgaggtccaa ctgatacagt ctggggctga ggtgaagaag cctggggcct cagtgaaggt
      181 ctcctgcgag gtttccggat acaccttcac cgaactgtcc atccactggg tgcgacaggc
      241 ccctggaaaa ggccttgagt ggatgggaag tgttgatcct gaatatggtg aaatgataaa
      301 cgcagaaaga ttccagggca gagtcacctt gaccgaggac acgtctacag gaacggccta
      361 catggagctg atcagtctga gatctgaaga cacggccgtg tattactgtg cgacatcacc
      421 cagcggcacc tggctatatt ggtacttcga tttctggggc cctggcaccc caatcaccat
      481 ctcctcagcc
//
LOCUS       KCXD01007725             504 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1102:7024:11829
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007725
VERSION     KCXD01007725.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 504)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 504)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1102:7024:11829"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    124..502
                     /note="immunoglobulin heavy chain variable region"
     V_region        124..502
     V_segment       124..415
                     /gene="IGHV1-170"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <409..>471
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66207.1"
                     /translation="CATHGGYSDIWSSLYHGLDSW"
     D_segment       424..433
                     /gene="IGHD6-36"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       455..502
                     /gene="IGHJ6-6"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        503..>504
                     /gene="IGHG"
BASE COUNT          121 a          147 c          140 g           96 t
ORIGIN      
        1 acatgggggc atcacacaac aaccacatcc ctcccctaca gaagccccag agcacagcac
       61 ctcaccatgg actggacctg gaggatcctc ctcttggtgg caacagccac cggcgcccac
      121 tctgaggtcc agctggtgca gtctggggct gaaattaaga agcctggggc ctcagtgatg
      181 gtctcctgcc aggtttccgg atacaccgtc accgaaattt ccatgcactg ggtgcgacag
      241 gcccctggaa aagggcttga gtggatggga agtgttgctc ctgaaaaaaa tgagttaata
      301 cacgcagaca agttccagga cagagtcacc atgaccgagg acacgtctac agacacagcc
      361 tacatggagc tgagcggcct gacatctgag gacacggccg tgtattactg tgcgacccac
      421 ggagggtata gcgacatctg gagctcccta tatcacggtt tggattcctg gggccaaggg
      481 gtcgtcgtca tcgtctcctc agcc
//
LOCUS       KCXD01007726             398 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1119:9696:16299
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007726
VERSION     KCXD01007726.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 398)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 398)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1119:9696:16299"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    72..396
                     /note="immunoglobulin heavy chain variable region"
     V_region        72..396
     V_segment       72..334
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <327..>365
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66208.1"
                     /translation="CASNSITSGPDYW"
     D_segment       340..346
                     /gene="IGHD1-2"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       360..396
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        397..>398
                     /gene="IGHG"
BASE COUNT           79 a          120 c          107 g           92 t
ORIGIN      
        1 acatgggggg ttctctgaga ggcacggaca tcctgtgcaa gaacatgagg cacctgtggt
       61 tcttcctcct cctggtgaag ccttcggaga ccctgtctct cacctgcgct gtctctggtg
      121 gctctatcag cggtaactac tggagctgga tccgccgggc cccagggaag ggactggagt
      181 ggattggata tatctacggt agtgatttta ccaccaacta caacccctcc ctcaagagtc
      241 gagtcaccct gtcagcagat acgtccaaga accagctctc cctgaacctg gcctctgtga
      301 ccgccgcgga cacggccgtc tatttctgtg ccagtaatag tataacatct ggtccagatt
      361 actggggccg gggagtcctg gtcaccgtct cctcagcc
//
LOCUS       KCXD01007727             462 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:1109:10904:6579
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007727
VERSION     KCXD01007727.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 462)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAR-2019) Yerkes NHP Core, Yerkes National Primate
            Research Center - Emory University, 954 Gatewood Rd NE, Atlanta, GA
            30329, United States of America
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Macaca mulatta"
                     /mol_type="genomic DNA"
                     /submitter_seqid="28:1:1109:10904:6579"
                     /isolate="RYm16 LLN"
                     /db_xref="taxon:9544"
                     /sex="male"
                     /cell_type="B cells"
                     /tissue_type="L inguinal lymph node"
     misc_feature    103..460
                     /note="immunoglobulin heavy chain variable region"
     V_region        103..460
     V_segment       103..395
                     /gene="IGHV4-117"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     CDS             <388..>429
                     /function="JUNCTION"
                     /inference="COORDINATES: protein motif:IgBLAST:1.6.1"
                     /codon_start=1
                     /product="immunoglobulin heavy chain junction region"
                     /protein_id="MOX66209.1"
                     /translation="CARGNIAATGIDYW"
     D_segment       402..411
                     /gene="IGHD6-33"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     J_segment       419..460
                     /gene="IGHJ4-3"
                     /inference="COORDINATES: alignment:IgBLAST:1.6.1"
                     /allele="01"
     C_region        461..>462
                     /gene="IGHG"
BASE COUNT           82 a          140 c          138 g          102 t
ORIGIN      
        1 acatggggat gctctctgag agtcacggac ctcctgtgca agaacatgaa gcacctgtgg
       61 ttcttcctcc tcctggtggt agctcccaga tgggtcctgt cccaggtgca gctgcaggag
      121 tcgggcccag gactggtgaa gccttcggag accctgtccc tcacctgcgc tgtctctggt
      181 ggctccatca gcggttactg gtggggctgg atccgccagt ccccagggaa ggggctggag
      241 tggattggct ttttcggtgg tagtggtggg agcacctact acaagtcctc cctccagagt
      301 cgagtcacca tttcaaccga cacgtccaag aaccagttct ccctgatact gacctctgtg
      361 accgccgcgg acacggccct ctattactgt gcgaggggga atatagcagc gactggcatt
      421 gactactggg gccagggacc cctggtcacc gtctcctcag cc
//
LOCUS       KCXD01007728             497 bp    DNA     linear   PRI 03-APR-2019
DEFINITION  TLS: Macaca mulatta isolate RYm16 LLN 28:1:2113:14108:17774
            immunoglobulin heavy chain variable region, sequence.
ACCESSION   KCXD01007728
VERSION     KCXD01007728.1
DBLINK      BioProject: PRJNA520929
            BioSample: SAMN10872191
            Sequence Read Archive: SRR8582642, SRR8582709
KEYWORDS    TLS; Targeted Locus Study; AIRR; MiAIRR:1.0.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 497)
  AUTHORS   Cirelli,K.M., Carnathan,D.G., Nogal,B., Rodriguez,O.L.,
            Martin,J.T., Upadhyay,A., Enemuo,C.A., Gebru,E.H., Choe,Y.,
            Viviano,F., Nakao,C., Pauthner,M., Reiss,S., Cottrell,C.A.,
            Bastidas,R., Gibson,W., Wolabaugh,A.N., Melo,M.B., Cosette,B.,
            Kuman,V., Patel,N., Tokatlian,T., Menis,S., Kulp,D.W., Burton,D.R.,
            Murrell,B., Bosinger,S.E., Schief,W.R., Ward,A.B., Watson,C.T.,
            Silvestri,G., Irvine,D.J. and Crotty,S.
  TITLE     Slow delivery immunization enhances HIV neutralizing antibody and
            germinal center responses via modulation of immunodominance
  JOURNAL   Unpublished
  REMARK    published on Zenodo 10.5281/zenodo.2573249 19-FEB (2019)
REFERENCE   2  (bases 1 to 497)
  AUTHORS   Upadhyay,A., Wolabaugh,A.N., Patel,N., Cirelli,K.M.,
            Carnathan,D.G., Reiss,S., Silvestri,G., Crotty,S. and Bosinger,S.E.
